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L-theanine

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https://www.readbyqxmd.com/read/29784304/contribution-of-l-theanine-to-the-formation-of-2-5-dimethylpyrazine-a-key-roasted-peanutty-flavor-in-oolong-tea-during-manufacturing-processes
#1
Xiangyang Guo, Chuankui Song, Chi-Tang Ho, Xiaochun Wan
l-Theanine, the most abundant amino acid in tea, is widely believed to be associated with the tea taste, however, its contribution to the formation of tea aroma is still unknown. Volatiles were determined and nitrogen-containing compounds formed during manufacturing processes were quantified. Lower levels of total sugar and l-theanine were detected in the Oolong tea product undergoing full fire processing (FFOT) suggesting that l-theanine probably involved in the volatile formation during manufacturing processes...
October 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29669412/novel-flavoalkaloids-from-white-tea-with-inhibitory-activity-against-formation-of-advanced-glycation-end-products
#2
Xiao Li, Guang-Jin Liu, Wei Zhang, Yv-Long Zhou, Tie-Jun Ling, Xiao-Chun Wan, Guan-Hu Bao
Two novel flavoalkaloids, (-)-6-(5'''S)-N-ethyl-2-pyrrolidinone-epigallocatechin -O-gallate (ester-type catechins pyrrolidinone A, etc-pyrrolidinone A, 1), (-)-6-(5'''R)-N-ethyl-2-pyrrolidinone-epigallocatechin-O-gallate (etc-pyrrolidinone B,2) and new naturally occurring flavoalkaloids (-)-8-N-ethyl-2-pyrrolidinone-epigallocatechin-O-gallate (etc-pyrrolidinone C,3a and etc- pyrrolidinone D,3b), were isolated from white tea (Camellia sinensis). Their structures were identified by extensive NMR spectra...
April 18, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29629712/l-theanine-protects-h9c2-cells-from-hydrogen-peroxide-induced-apoptosis-by-enhancing-antioxidant-capability
#3
Chengjian Li, Qiongxian Yan, Shaoxun Tang, Wenjun Xiao, Zhiliang Tan
BACKGROUND L-theanine is a non-protein amino acid in green tea, and its hepatoprotection and neuroprotection have been verified. However, whether L-theanine can prevent cardiomyocytes from apoptosis is unclear yet. This study evaluated the protective effects of L-theanine on H2O2-induced heart injury in vitro. MATERIAL AND METHODS The certified H9C2 cells were pretreated with L-theanine (0 mM, 4 mM, 8 mM, and 16 mM) for 24 h, followed by 160 µM H2O2 solution for 4 h. The cell viability and antioxidant indices were assayed...
April 9, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29629512/-l-theanine-decreases-orofacial-dyskinesia-induced-by-reserpine-in-rats
#4
Hung-Sheng Soung, Mao-Hsien Wang, Kuo-Chi Chang, Cheng-Neng Chen, Yi Chang, Chih-Chuan Yang, Hsiang-Chien Tseng
Reserpine (RES)-induced orofacial dyskinesia (OD) has been used as an animal model for human tardive dyskinesia (TD) for decades, due to its strong pathophysiological association with striatal oxidative stress and neural cytoarchitecture alteration. L -Theanine (LT), one of the major amino acid components in green tea, has potent antioxidative, anti-inflammatory, and neuroprotective effects. In this study, we examined the potential protective effects of LT on RES-induced behavioral and neurochemical dysfunction in rats...
April 9, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29568741/alteration-of-mevalonate-pathway-in-rat-splenic-lymphocytes-possible-role-in-cytokines-secretion-regulated-by-l-theanine
#5
Chengjian Li, Qiongxian Yan, Shaoxun Tang, Wenjun Xiao, Zhiliang Tan
L-Theanine is a nonprotein amino acid in tea, and its immunomodulatory function has been confirmed. This study aimed to investigate the effect of L-theanine addition on cytokines secretion in rat splenic lymphocytes and explore its potential immunomodulatory effects on the mevalonate biosynthetic pathway. Our results showed that L-theanine treatment did not influence the proliferation and division indexes of the splenic lymphocytes subsets. Interestingly, L-theanine treatment had regulated the contents of IFN- γ , IL-2, IL-4, IL-10, IL-12, and TNF- α   ( P < 0...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29482046/pharmacological-values-and-therapeutic-properties-of-black-tea-camellia-sinensis-a-comprehensive-overview
#6
REVIEW
Muhammad Naveed, Jannat BiBi, Asghar Ali Kamboh, Imran Suheryani, Ihsanullah Kakar, Sarfaraz Ali Fazlani, Xia FangFang, Shahmir Ali Kalhoro, Liang Yunjuan, Mohib Ullah Kakar, Mohamed E Abd El-Hack, Ahmed E Noreldin, Shi Zhixiang, Chen LiXia, Zhou XiaoHui
Medicinal plants are essential parts of traditional medicine due to their phytochemical constituents having pharmacological values and therapeutic applications. Black tea have thousands of various biological compounds such as flavonoids (Thearubigins (TRs) and theaflavins (TFs) and catechins), amino acids (L.theanine), vitamins (A, C, K), phenolic acids (caffeic acid (CA), gallic acid (GA), chlorogenic acids (CGA) and cauramic acid), lipids, proteins, volatile compounds carbohydrates, β-carotene and fluoride that illustrated many promising pharmacological effects regarded as growth promoter, cardioprotector, potent cholesterol-lowering effect, antioxidant and antimicrobial, etc inhuman...
April 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29458014/topical-delivery-of-l-theanine-ameliorates-tpa-induced-acute-skin-inflammation-via-downregulating-endothelial-pecam-1-and-neutrophil-infiltration-and-activation
#7
Wei-Jie Zeng, Zhi Tan, Xing-Fei Lai, Ya-Nan Xu, Chun-Lin Mai, Jun Zhang, Zhen-Jia Lin, Xian-Guo Liu, Shi-Li Sun, Li-Jun Zhou
l-theanine, the most abundant free amino acid in tea, has been documented to possess many different bioactive properties through oral or intragastrical delivery. However, little is known about the effect of topical delivery of l-theanine on acute inflammation. In the present study, by using 12-O-tetradecanoylphorbol-13-acetate (TPA, 2.5 μg/ear)-induced ear edema model in mice, we first found that single-dose local pretreatment of l-theanine 30 min before TPA time- and dose-dependently suppressed the increases in both skin thickness and weight...
March 25, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29420994/l-theanine-and-caffeine-improve-target-specific-attention-to-visual-stimuli-by-decreasing-mind-wandering-a-human-functional-magnetic-resonance-imaging-study
#8
Chanaka N Kahathuduwa, Chathurika S Dhanasekara, Shao-Hua Chin, Tyler Davis, Vajira S Weerasinghe, Tharaka L Dassanayake, Martin Binks
Oral intake of l-theanine and caffeine supplements is known to be associated with faster stimulus discrimination, possibly via improving attention to stimuli. We hypothesized that l-theanine and caffeine may be bringing about this beneficial effect by increasing attention-related neural resource allocation to target stimuli and decreasing deviation of neural resources to distractors. We used functional magnetic resonance imaging (fMRI) to test this hypothesis. Solutions of 200mg of l-theanine, 160mg of caffeine, their combination, or the vehicle (distilled water; placebo) were administered in a randomized 4-way crossover design to 9 healthy adult men...
January 2018: Nutrition Research
https://www.readbyqxmd.com/read/29401695/influence-of-graded-levels-of-l-theanine-dietary-supplementation-on-growth-performance-carcass-traits-meat-quality-organs-histomorphometry-blood-chemistry-and-immune-response-of-broiler-chickens
#9
Muhammad Saeed, Xu Yatao, Faiz-Ul Hassan, Muhammad Asif Arain, Mohamed E Abd El-Hack, Ahmed E Noreldin, Chao Sun
l-theanine is a water-soluble non-proteinous amino acid mainly found in green tea leaves. Despite the availability of abundant literature on green tea, studies on the use of l-theanine as a feed additive in animals, and especially broilers are limited. The objective of this study was, therefore, to evaluate the effect of different dietary levels of l-theanine on meat quality, growth performance, immune response, and blood metabolites in broilers. A total of 400 day-old broiler chicks were randomly divided into four treatment groups using a completely randomized design; C-control, basal diet; 100LT-basal diet + 100 mg l-theanine/kg diet; 200LT-basal diet + 200 mg l-theanine/kg diet; and 300LT-basal diet + 300 mg l-theanine/kg diet...
February 3, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29374957/protective-effect-of-l-theanine-on-haloperidol-induced-orofacial
#10
Cheng-Neng Chen, Kuo-Chi Chang, Mao-Hsien Wang, Hsiang-Chien Tseng, Hung-Sheng Soung
Tardive dyskinesia (TD) is a severe side effect of chronic neuroleptic treatment consisting of abnormal involuntary movements, characterized by orofacial dyskinesia (OD). Haloperidol (HAL)- induced OD has been widely used as an animal model to study the neuropathophysiology of human TD with its pathophysiology strongly associated with striatal oxidative stress. L-Theanine (LT), one of the major amino acid components in green tea, has potent antioxidative effects and is able to protect against various oxidative injuries...
February 28, 2018: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/29289576/botanicals-and-phytochemicals-active-on-cognitive-decline-the-clinical-evidence
#11
REVIEW
Arrigo F G Cicero, Federica Fogacci, Maciej Banach
Beyond the well-known effects on cognitive impairment of the Mediterranean diet, a number of studies have investigated the possible action on cognitive decline of different botanicals and phytochemicals, most of which are well-known anti-inflammatory or antioxidant agents with a good tolerability and safety profile. In particular, the current literature supports the use of Ginkgo biloba, resveratrol, epigallocatechin-3-gallate and l-theanine, Theobroma cacao, Bacopa monnieri, Crocus sativus and curcumin, which might have a positive impact on cognitive impairment used alone or in combination with other nutraceuticals or traditional drugs...
December 28, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29215606/cognitive-and-mood-effects-of-a-nutrient-enriched-breakfast-bar-in-healthy-adults-a-randomised-double-blind-placebo-controlled-parallel-groups-study
#12
David O Kennedy, Emma L Wightman, Joanne Forster, Julie Khan, Crystal F Haskell-Ramsay, Philippa A Jackson
OBJECTIVES: Few previous studies have assessed the effects of concomitant administration of multiple potentially psychoactive nutrients. METHODS: 95 healthy adult participants consumed either a nutrient enriched breakfast bar (containing α-Linolenic acid, l-tyrosine, l-theanine, vitamins, minerals and 21.5 mg of caffeine) or an isocaloric, macronutrient matched control bar for 56 days. Cognitive function and mood were assessed pre-dose and at 40- and 160-min post-dose on the 1st and 56th day of the intervention period...
December 7, 2017: Nutrients
https://www.readbyqxmd.com/read/29188854/short-term-impact-of-a-combined-nutraceutical-on-cognitive-function-perceived-stress-and-depression-in-young-elderly-with-cognitive-impairment-a-pilot-double-blind-randomized-clinical-trial
#13
A F Cicero, M Bove, A Colletti, M Rizzo, F Fogacci, M Giovannini, C Borghi
BACKGROUND: The prevalence of senile dementia is increasing worldwide, especially in the developed countries. Nevertheless, drug therapy isn't often enough to treat this condition. Researchers are evaluating the possible impact of a preventive approach, based on an improvement of lifestyle and the intake of micronutrients. Moreover, there is an increasing interest for combined nutraceuticals that can act as memory and learning enhancers, with a significant and beneficial potential on the cognitive disorders...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29163391/-colletotrichum-gloeosporioides-contaminated-tea-infusion-blocks-lipids-reduction-and-induces-kidney-damage-in-mice
#14
Jin Li, Kang Sun, Qingping Ma, Jin Chen, Le Wang, Dingjun Yang, Xuan Chen, Xinghui Li
When the homogenate of fresh tea tree leaves was fermented to produce black tea beverage, the Colletotrichum gloeosporioides (main pathogen or endophyte of Camellia sinensis ) may be mixed into the fermentation liquor. However, it was unclear whether C. gloeosporioides- contaminated tea beverage would damage human health. Therefore, we investigated the changes of functional components and the influences on mice. C. gloeosporioides was added to the green tea infusion. After cultivation of 48 h, tea polyphenols, caffeine, and L-theanine decreased by 31...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29080788/l-theanine-prevents-etec-induced-liver-damage-by-reducing-intrinsic-apoptotic-response-and-inhibiting-erk1-2-and-jnk1-2-signaling-pathways
#15
Zhihua Gong, Qiuling Liu, Ling Lin, Yanli Deng, Shuxian Cai, Zunying Liu, Sheng Zhang, Wenjun Xiao, Shuo Xiong, Dong Chen
l-Theanine (LTA; γ-glutamylethylamide), a peculiar non-protein-derived amino acid isolated from tea, is widely used as a functional ingredient and dietary supplement. l-Theanine has been confirmed to have hepatoprotective effects, but the underlying mechanism remains unknown. This study investigated the protective effect of l-Theanine-in vivo, using an enterotoxigenic Escherichia coli (ETEC)-infected mouse model. l-Theanine significantly decreased the elevated serum activities of both aspartate aminotransferase (AST) and alanine aminotransferase (ALT), two biomarkers of hepatic impairment...
January 5, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29037735/l-theanine-an-astounding-sui-generis-integrant-in-tea
#16
REVIEW
Eshita Sharma, Robin Joshi, Ashu Gulati
l-theanine (l-Th), a non-protein amino acid present in tea, is a valuable nutraceutical product with unique health benefits and used as an additive in food industry. l-Th enhances the umami taste but its use is limited due to its inadequate production. Different extraction approaches from tea shoots, chemical synthesis to microbial transformation have been tried to meet its demand. In vitro, in vivo as well as clinical studies have shown its positive effect in regulating CNS disorders. l-Th has become choice ingredient in CNS active products due to its anti-stress and neuroprotective role in dementias particularly in retrogression of Alzheimer's...
March 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29034642/-construction-of-recombinant-strains-co-expressing-ppk-and-gmas-for-the-synthesis-of-l-theanine
#17
Yuan Li, Shan Liu, Jun Zhu
Recombinant strains expressing enzymes for ATP regeneration and L-theanine production were constructed and used for the synthesis of L-theanine. The ppk gene encoding polyphosphate kinase (PPK) from Rhodobacter sphaeroides and gmas gene encoding γ-glutamylmethylamide synthetase (GMAS) from Methylovorus mays were synthesized, and two recombinant plasmids, pETDuet-ppk+gmas and pET21a-ppk+gmas were constructed for co-expression of PPK and GMAS in Escherichia coli BL21(DE3). SDS-PAGE analysis showed that PPK and GMAS were overexpressed in soluble form in both recombinant strains...
December 25, 2016: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/28971241/effects-of-l-theanine-on-anxiety-like-behavior-cerebrospinal-fluid-amino-acid-profile-and-hippocampal-activity-in-wistar-kyoto-rats
#18
Shintaro Ogawa, Miho Ota, Jun Ogura, Koichi Kato, Hiroshi Kunugi
RATIONALE AND OBJECTIVES: The amino acid L-theanine (N-ethyl-L-glutamine) has historically been considered a relaxing agent. In the present study, we examined the effects of repeated L-theanine administration on behavior, levels of amino acids in the cerebrospinal fluid (CSF), and hippocampal activity in Wistar Kyoto (WKY) rats, an animal model of anxiety and depressive disorders. METHODS: Behavioral tests were performed after 7-10 days of L-theanine (0.4 mg kg-1  day-1 ) or saline administration, followed by CSF sampling for high-performance liquid chromatography (HPLC) analysis...
January 2018: Psychopharmacology
https://www.readbyqxmd.com/read/28946262/validation-of-a-reversed-phase-high-performance-liquid-chromatographic-method-for-the-determination-of-free-amino-acids-in-rice-using-l-theanine-as-the-internal-standard
#19
G V V Liyanaarachchi, K R R Mahanama, H P P S Somasiri, P A N Punyasiri
The study presents the validation results of the method carried out for analysis of free amino acids (FAAs) in rice using l-theanine as the internal standard (IS) with o-phthalaldehyde (OPA) reagent using high-performance liquid chromatography-fluorescence detection. The detection and quantification limits of the method were in the range 2-16μmol/kg and 3-19μmol/kg respectively. The method had a wide working range from 25 to 600μmol/kg for each individual amino acid, and good linearity with regression coefficients greater than 0...
February 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28938517/green-tea-camellia-sinensis-and-l-theanine-medicinal-values-and-beneficial-applications-in-humans-a-comprehensive-review
#20
REVIEW
Muhammad Saeed, Muhammad Naveed, Muhammad Arif, Mohib Ullah Kakar, Robina Manzoor, Mohamed Ezzat Abd El-Hack, Mahmoud Alagawany, Ruchi Tiwari, Rekha Khandia, Ashok Munjal, Kumaragurubaran Karthik, Kuldeep Dhama, Hafiz M N Iqbal, Maryam Dadar, Chao Sun
Green tea (Camellia sinensis) is a famous herb, and its extract has been extensively used in traditional Chinese medicinal system. In this context, several studies have revealed its health benefits and medicinal potentialities for several ailments. With ever increasing scientific knowledge, search for safer, potential and novel type of health-related supplements quest, scientists are re-directing their research interests to explore natural resources i.e. medicinal herbs/plant derived compounds. Green tea consumption has gained a special attention and popularity in the modern era of changing lifestyle...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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