keyword
MENU ▼
Read by QxMD icon Read
search

L-theanine

keyword
https://www.readbyqxmd.com/read/28511005/characterization-of-l-theanine-excitatory-actions-on-hippocampal-neurons-towards-the-generation-of-novel-n-methyl-d-aspartate-receptor-modulators-based-on-its-backbone
#1
Fatiha Sebih, Matthieu Rousset, Salima Bellahouel, Marc Rolland, Marie Celeste de Jesus Ferreira, Janique Guiramand, Catherine Cohen-Solal, Gérard Barbanel, Thierry Cens, Mohammed Abouazza, Adrien Tassou, Maud Gratuze, Céline Meunier, Pierre Charnet, Michel Vignes, Valérie Rolland
L-Theanine (or L-γ-N-ethyl-glutamine) is the major amino acid found in Camellia sinensis. It has received much attention because of its pleiotropic physiological and pharmacological activities leading to health benefits in humans, especially. We describe here a new, easy, efficient and environmentally-friendly chemical synthesis of L-Theanine and L-γ-N-propyl-Gln and their corresponding D isomers. L-Theanine, and its derivatives obtained so far, exhibited partial co-agonistic action at N-methyl-D-aspartate (NMDA) receptors, with no detectable agonist effect at other glutamate receptors, on cultured hippocampal neurons...
May 16, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28439281/l-theanine-content-and-related-gene-expression-novel-insights-into-theanine-biosynthesis-and-hydrolysis-among-different-tea-plant-camellia-sinensis-l-tissues-and-cultivars
#2
Zhi-Wei Liu, Zhi-Jun Wu, Hui Li, Yong-Xin Wang, Jing Zhuang
L-Theanine content has tissues and cultivars specificity in tea plant (Camellia sinensis L.), the correlations of theanine metabolic related genes expression profiles with theanine contents were explored in this study. L-theanine contents in the bud and 1st leaf, 2nd leaf, 3rd leaf, old leaf, stem, and lateral root were determined by HPLC from three C. sinensis cultivars, namely 'Huangjinya', 'Anjibaicha', and 'Yingshuang', respectively. The theanine contents in leaves and root of 'Huangjinya' were the highest, followed by 'Anjibaicha', and 'Yingshuang'...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28391425/safety-tolerability-and-efficacy-of-drugs-for-treating-behavioural-insomnia-in-children-with-attention-deficit-hyperactivity-disorder-a-systematic-review-with-methodological-quality-assessment
#3
REVIEW
Shweta Anand, Henry Tong, Frank M C Besag, Esther W Chan, Samuele Cortese, Ian C K Wong
OBJECTIVE: A large proportion of paediatric patients with attention-deficit/hyperactivity disorder (ADHD) have associated sleep problems which not only affect the child's wellbeing but also impact family functioning. Management of sleep problems is consequently an important aspect of overall ADHD management in paediatric patients. Although some drugs are being used off-label for the management of paediatric insomnia, there is scant clinical evidence supporting their use. Our aim was to identify and assess the quality of published studies reporting the safety, tolerability and efficacy of drugs used for treating behavioural insomnia in children with ADHD...
June 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28365292/evolving-transpeptidase-and-hydrolytic-variants-of-%C3%AE-glutamyl-transpeptidase-from-bacillus-licheniformis-by-targeted-mutations-of-conserved-residue-arg109-and-their-biotechnological-relevance
#4
Shruti Bindal, Sujata Sharma, Tej P Singh, Rani Gupta
γ-Glutamyl transpeptidase (GGT) catalyzes the transfer of the γ-glutamyl moiety from donor compounds such as l-glutamine (Gln) and glutathione (GSH) to an acceptor. During the biosynthesis of various γ-glutamyl-containing compounds using GGT enzyme, auto-transpeptidation reaction leads to the formation of unwanted byproducts. Therefore, in order to alter the auto-transpeptidase activity of the GGT enzyme, the binding affinity of Gln should be modified. Structural studies of the Bacillus licheniformis GGT (BlGT) complexed with the glutamic acid has shown that glutamic acid has strong ionic interactions through its α-carboxlic group with the guanidine moiety of Arg109...
March 30, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28056735/effect-of-green-tea-phytochemicals-on-mood-and-cognition
#5
Christina Dietz, Matthijs Dekker
BACKGROUND: Green tea is traditionally known to induce mental clarity, cognitive function, physical activation and relaxation. Recently, a special green tea, matcha tea, is rapidly gaining popularity throughout the world and is frequently referred to as a mood- and brain food. Matcha tea consumption leads to much higher intake of green tea phytochemicals compared to regular green tea. Previous research on tea constituents caffeine, L-theanine, and epigallocatechin gallate (EGCG) repeatedly demonstrated benefits on mood and cognitive performance...
January 5, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28044450/caffeine-and-theanine-exert-opposite-effects-on-attention-under-emotional-arousal
#6
Grace E Giles, Caroline R Mahoney, Tad T Brunyé, Holly A Taylor, Robin B Kanarek
Tea is perceived as more relaxing than coffee, even though both contain caffeine. L-theanine in tea may account for the difference. Consumed together, caffeine and theanine exert similar cognitive effects to that of caffeine alone, but exert opposite effects on arousal, in that caffeine accentuates and theanine mitigates physiological and felt stress responses. We evaluated whether caffeine and theanine influenced cognition under emotional arousal. Using a double-blind, repeated-measures design, 36 participants received 4 treatments (200 mg caffeine + 0 mg theanine, 0 mg caffeine + 200 mg theanine, 200 mg caffeine + 200 mg theanine, 0 mg caffeine + 0 mg theanine) on separate days...
January 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/27908701/inhibitory-effects-of-l-theanine-on-airway-inflammation-in-ovalbumin-induced-allergic-asthma
#7
Yong Pil Hwang, Sun Woo Jin, Jae Ho Choi, Chul Yung Choi, Hyung Gyun Kim, Se Jong Kim, Yongan Kim, Kyung Jin Lee, Young Chul Chung, Hye Gwang Jeong
l-theanine, a water-soluble amino acid isolated from green tea (Camellia sinensis), has anti-inflammatory activity, antioxidative properties, and hepatoprotective effects. However, the anti-allergic effect of l-theanine and its underlying molecular mechanisms have not been elucidated. In this study, we investigated the protective effects of l-theanine on asthmatic responses, particularly airway inflammation and oxidative stress modulation in an ovalbumin (OVA)-induced murine model of asthma. Treatment with l-theanine dramatically attenuated the extensive trafficking of inflammatory cells into bronchoalveolar lavage fluid (BALF)...
January 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27698535/l-theanine-protects-against-excess-dopamine-induced-neurotoxicity-in-the-presence-of-astrocytes
#8
Mika Takeshima, Ikuko Miyazaki, Shinki Murakami, Taizo Kita, Masato Asanuma
l-Theanine (γ-glutamylethylamide), a component of green tea, is considered to have regulatory and neuroprotective roles in the brain. The present study was designed to determine the effect of l-theanine on excess dopamine-induced neurotoxicity in both cell culture and animal experiments. The primary cultured mesencephalic neurons or co-cultures of mesencephalic neurons and striatal astrocytes were pretreated with l-theanine for 72 h, and then treated with excess dopamine for further 24 h. The cell viability of dopamine neurons and levels of glutathione were evaluated...
September 2016: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/27664666/preparation-of-sers-active-substrates-based-on-graphene-oxide-silver-nanocomposites-for-rapid-zdetection-of-l-theanine
#9
Huajun Zheng, Dejiang Ni, Zhi Yu, Pei Liang
A kind of graphene oxide/silver (GO/Ag) nanocomposites with high Surface enhanced Raman scattering (SERS) activity were fabricated via a facile and green liquid phase reduction method. The synthesized materials were characterized in detail using various microscopic and spectroscopic techniques. In this method, the GO sheets worked as a holder which makes silver nanoparticles (AgNPs) aggregate to a particular morphology, and under a suitable dosage of silver ions, well-dispersed AgNPs on the surface of GO were obtained, which could generate more "hot spots" of SERS...
February 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27649883/l-theanine-attenuates-cadmium-induced-neurotoxicity-through-the-inhibition-of-oxidative-damage-and-tau-hyperphosphorylation
#10
Peiling Ben, Zhengping Zhang, Yanyan Zhu, Aiying Xiong, Yanhong Gao, Jianyun Mu, Zhimin Yin, Lan Luo
Cadmium (Cd) has long been known to induce neurological degenerative disorders. We studied effects of l-theanine, one of the major amino acid components in green tea, on Cd-induced brain injury in mice. Male ICR mice were intraperitoneally injected with l-theanine (100 or 200mg/kg/day) or saline and after one hour these mice were orally administrated with CdCl2 (3.75-6mg/kg). The treatment was conducted for 8 weeks. l-Theanine significantly reduced Cd level in the mouse brain and plasma. Cd-induced neuronal cell death in the mouse cortex and hippocampus were apparently inhibited by l-theanine treatment...
September 17, 2016: Neurotoxicology
https://www.readbyqxmd.com/read/27623718/new-phytochemicals-as-potential-human-anti-aging-compounds-reality-promise-and-challenges
#11
Rubia C G Corrêa, Rosane M Peralta, Charles W I Haminiuk, Giselle Maria Maciel, Adelar Bracht, Isabel C F R Ferreira
Aging is an inevitable process influenced by genetic, lifestyle and environmental factors. Indirect evidence shows that several phytochemicals can have anti-aging capabilities, although direct evidence in this field is still limited. This report aims to provide a critical review on aspects related to the use of novel phytochemicals as anti-aging agents, to discuss the obstacles found when performing most anti-aging study protocols in humans, and to analyze future perspectives. In addition to the extensively studied resveratrol, epicatechin, quercetin and curcumin, new phytochemicals have been reported to act as anti-aging agents, such as the amino acid L-theanine isolated from green tea, and the lignans arctigenin and matairesinol isolated from Arctium lappa seeds...
September 13, 2016: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/27612630/theanine-from-tea-and-its-semi-synthetic-derivative-tbrc-suppress-human-cervical-cancer-growth-and-migration-by-inhibiting-egfr-met-akt-nf-%C3%AE%C2%BAb-signaling
#12
Jiannan Liu, Yuping Sun, Huarong Zhang, Dexin Ji, Fei Wu, Huihui Tian, Kun Liu, Ying Zhang, Benhao Wu, Guoying Zhang
Cervical cancer is the third most prevalent cancer among women worldwide. Theanine from tea and its derivatives show some anticancer activities. However, the role of theanine and its derivatives against human cervical cancer and the molecular mechanisms of action remain unclear. Thus, in this study, we aim to investigate the anticancer activities and underlying mechanisms of theanine and a theanine derivative, ethyl 6-bromocoumarin-3- carboxylyl L-theanine (TBrC), against human cervical cancer. In vitro and in vivo assays for cancer cell growth and migration have confirmed the inhibition of the cell growth and migration by TBrC and theanine in highly-metastatic human cervical cancer...
November 15, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27396868/effects-of-chronic-l-theanine-administration-in-patients-with-major-depressive-disorder-an-open-label-study
#13
Shinsuke Hidese, Miho Ota, Chisato Wakabayashi, Takamasa Noda, Hayato Ozawa, Tsutomu Okubo, Hiroshi Kunugi
OBJECTIVE: l-theanine, an amino acid uniquely contained in green tea (Camellia sinensis), has been suggested to have various psychotropic effects. This study aimed to examine whether l-theanine is effective for patients with major depressive disorder (MDD) in an open-label clinical trial. METHODS: Subjects were 20 patients with MDD (four males; mean age: 41.0±14.1 years, 16 females; 42.9±12.0 years). l-theanine (250 mg/day) was added to the current medication of each participant for 8 weeks...
April 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27019564/theanine-and-caffeine-content-of-infusions-prepared-from-commercial-tea-samples
#14
Klára Boros, Nikoletta Jedlinszki, Dezső Csupor
BACKGROUND: Caffeine and L-theanine are pharmacologically important constituents of tea, especially due to their effects on the central nervous system. The effects of these two compounds are opposite: While caffeine is a well-known stimulant, theanine has a relaxing effect. Tea processing may influence the caffeine and theanine content of tea leaves. OBJECTIVE: The aim of our work was to quantify these constituents from a set of commercial products to reveal the possible correlations of caffeine and theanine content and processing methods...
January 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/26957301/l-theanine-a-component-of-green-tea-prevents-3-nitropropionic-acid-3-np-induced-striatal-toxicity-by-modulating-nitric-oxide-pathway
#15
Sumit Jamwal, Puneet Kumar
L-theanine is unique amino acid which readily crosses blood brain barrier and possesses neuroprotective potential against neurodegenerative disorders including Huntington disease (HD). HD is characterized by selective loss of GABAergic medium spiny neurons. 3-nitropropionic acid (3-NP) induces a spectrum of HD-like neuropathology in rat striatum and widely used as experimental tool to study HD. Therefore, the present study was intended to investigate the effect of L-theanine against 3-NP-induced striatal toxicity and to explore its possible mechanism...
March 9, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/26922362/l-theanine-improves-immunity-by-altering-th2-th1-cytokine-balance-brain-neurotransmitters-and-expression-of-phospholipase-c-in-rat-hearts
#16
Chengjian Li, Haiou Tong, Qiongxian Yan, Shaoxun Tang, Xuefeng Han, Wenjun Xiao, Zhiliang Tan
BACKGROUND This study aimed to investigate the regulatory effects of L-theanine on secretion of immune cytokines, hormones, and neurotransmitters, and mRNA expression of phospholipase C (PLC) in rats, and to explore its regulatory mechanism in immune function. MATERIAL AND METHODS Sixty-four Sprague-Dawley rats received daily intragastric infusion of different doses of L-theanine solution [0, 50 (LT), 200 (MT), and 400 (HT) mg/kg BW]. Cytokines, immunoglobulins, and hormones in the serum, neurotransmitters, and mRNA expression of PLC in the relevant tissues were assayed...
February 28, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/26902467/the-single-and-synergistic-effects-of-the-major-tea-components-caffeine-epigallocatechin-3-gallate-and-l-theanine-on-rat-sperm-viability
#17
Tânia R Dias, Marco G Alves, Susana Casal, Branca M Silva, Pedro F Oliveira
Caffeine, epigallocatechin-3-gallate (EGCG) and L-theanine are the major components of tea (Camellia sinensis L.) and the main representatives of the classes of methylxanthines, catechins and free amino acids present in this beverage. There are many studies reporting tea's health benefits, however it is not clear if those effects are mediated by a single component or a synergistic action. This study aimed to evaluate the individual and synergistic effects of tea's major components on rat epididymal spermatozoa survival and oxidative profile during 3-day storage at room temperature (RT)...
March 2016: Food & Function
https://www.readbyqxmd.com/read/26869148/acute-effects-of-theanine-caffeine-and-theanine-caffeine-combination-on-attention
#18
Chanaka N Kahathuduwa, Tharaka L Dassanayake, A M Tissa Amarakoon, Vajira S Weerasinghe
Objective l-theanine is a constituent of tea which is claimed to enhance cognitive functions. We aimed to determine whether theanine and theanine-caffeine combination have acute positive effects on cognitive and neurophysiological measures of attention, compared to caffeine (a positive control) and a placebo in healthy individuals. Design In a placebo-controlled, five-way crossover trial in 20 healthy male volunteers, we compared the effects of l-theanine (200 mg), caffeine (160 mg), their combination, black tea (one cup) and a placebo (distilled water) on cognitive (simple [SVRT] and recognition visual reaction time [RVRT]) and neurophysiological (event-related potentials [ERPs]) measures of attention...
February 11, 2016: Nutritional Neuroscience
https://www.readbyqxmd.com/read/26828717/l-theanine-inhibits-proinflammatory-pkc-erk-icam-1-il-33-signaling-apoptosis-and-autophagy-formation-in-substance-p-induced-hyperactive-bladder-in-rats
#19
Wen-Hsin Tsai, Chung-Hsin Wu, Hong-Jeng Yu, Chiang-Ting Chien
AIMS: Upregulation of substance P (SP) and neurokinin-1 receptor (NK1R) activation induces pro-inflammatory bladder hyperactivity through the PKC/ERK/NF-κB/ICAM-1/IL-33 signaling pathways to increase the leukocyte infiltration and adhesion leading to reactive oxygen species (ROS) production, autophagy, and apoptosis. l-Theanine is a unique non-protein-forming amino acid present in tea (Camellia sinensis [L.] O. Kuntze) with its antioxidant, anti-inflammatory, and relaxation effects to improve cognition, mood, gastric ulcer injury, and cerebral ischemia/reperfusion injury, and posttraumatic stress disorder...
February 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/26826962/l-theanine-alleviates-the-neuropathological-changes-induced-by-pcb-aroclor-1254-via-inhibiting-upregulation-of-inflammatory-cytokines-and-oxidative-stress-in-rat-brain
#20
Thangarajan Sumathi, Deivasigamani Asha, Ganesan Nagarajan, Arivazhagan Sreenivas, Rajendran Nivedha
The present study is aimed at evaluating the protective role of L-theanine on aroclor 1254-induced oxidative stress in rat brain. Intraperitoneal administration of Aroclor 1254 (2 mg/kg b.wt. for 30 days) caused oxidative stress in rat brain and also caused neurobehavioral changes. Oxidative stress was assessed by determining the levels of lipid peroxide (LPO), protein carbonyl content, and changes in activities of creatine kinase (CK), acetylcholinesterase (AchE), and ATPases in the hippocampus, cerebellum and cerebral cortex of control and experimental rats...
March 2016: Environmental Toxicology and Pharmacology
keyword
keyword
12335
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"