Song Zhang, Karen Dsouza, Narasimha M Beeraka, Junqi Liu, Oksana Reshetniak, Hemanth Vikram Pr, L G Priyanka, M V Greeshma, Pradeep Kumar Bhupalam, Mahesh Pa, Prasath Manogaran, Rajashree Deka, Gurupadayya Bannimath, Mikhail Y Sinelnikov, Vladimir N Nikolenko, Kirill Bulygin, Ruitai Fan
Previous studies described that asthma patients who received corticosteroid therapy have been constrained by the corticosteroid resistance subsequently fostered to severe refractory asthma. In this review, we discussed the implications of TSLP, RXR, the role of STAT5-activating cytokines, and IL-33/NH-cell signaling pathways, and recent clinical evidence on TSLP blockers in steroid-resistant asthma. We have searched several public databases such as Pubmed, Scopus, and Relemed and obtained information pertinent to the TSLP, RXR, TSLP blockers, the STAT5-activating cytokines, and IL-33...
February 16, 2024: Current Medicinal Chemistry