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https://www.readbyqxmd.com/read/28092372/direct-control-of-regulatory-t-cells-by-keratinocytes
#1
Mariko Kashiwagi, Junichi Hosoi, Jen-Feng Lai, Janice Brissette, Steven F Ziegler, Bruce A Morgan, Katia Georgopoulos
Environmental challenges to epithelial cells trigger gene expression changes that elicit context-appropriate immune responses. We found that the chromatin remodeler Mi-2β controls epidermal homeostasis by regulating the genes involved in keratinocyte and immune-cell activation to maintain an inactive state. Mi-2β depletion resulted in rapid deployment of both a pro-inflammatory and an immunosuppressive response in the skin. A key target of Mi-2β in keratinocytes is the pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP)...
January 16, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28063040/a-mouse-model-for-atopic-dermatitis-using-topical-application-of-vitamin-d3-or-of-its-analog-mc903
#2
Verena Moosbrugger-Martinz, Matthias Schmuth, Sandrine Dubrac
Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disease with pruritus and high prevalence. Indeed, 15-30 % of children and 2-10 % of adults from industrialized countries are affected. Acute AD lesions are characterized by epidermal hyperplasia associated with a dominant Th2/Th17 immune response and dermal inflammatory infiltrates. Moreover, the expression of alarmins such as TSLP, IL-33, and IL-25 is upregulated in acute AD lesions. Topical application of vitamin D3 or of its low-calcemic analog MC903 induces changes in skin morphology and inflammation resembling immune perturbations observed in acute lesions of patients with AD...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28057434/atopic-dermatitis-immune-deviation-barrier-dysfunction-ige-autoreactivity-and-new-therapies
#3
REVIEW
Masutaka Furue, Takahito Chiba, Gaku Tsuji, Dugarmaa Ulzii, Makiko Kido-Nakahara, Takeshi Nakahara, Takafumi Kadono
Atopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely pruritic skin disorder mostly associated with IgE elevation and skin barrier dysfunction due to decreased filaggrin expression. The lesional skin of AD exhibits Th2- and Th22-deviated immune reactions that are progressive during disease chronicity. Th2 and Th22 cytokines further deteriorate the skin barrier by inhibiting filaggrin expression. Some IgEs are reactive to self-antigens. The IgE autoreactivity may precipitate the chronicity of AD...
January 2, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28049868/expression-of-epithelial-cell-derived-cytokine-genes-in-the-duodenal-and-colonic-mucosae-of-dogs-with-chronic-enteropathy
#4
Hironari Osada, Misato Ogawa, Ayana Hasegawa, Makoto Nagai, Junsuke Shirai, Kazuaki Sasaki, Minoru Shimoda, Hiroshi Itoh, Hirotaka Kondo, Keitaro Ohmori
It remains unclear whether epithelial cell-derived cytokines, including interleukin (IL)-25, IL-33 and thymic stromal lymphopoietin (TSLP), contribute to development of canine chronic enteropathy (CE), which includes antibiotic-responsive enteropathy (ARE), food-responsive enteropathy (FRE) and inflammatory bowel disease (IBD). In the present study, we examined mRNA expression of il-25, il-33 and tslp in the duodenal and colonic mucosae of dogs with ARE, FRE and IBD. Real-time PCR analysis revealed that mRNA expression of il-33 was significantly lower in the duodenum in dogs with FRE than in healthy dogs...
December 29, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28005965/formaldehyde-induced-aggravation-of-pruritus-and-dermatitis-is-associated-with-the-elevated-expression-of-th1-cytokines-in-a-rat-model-of-atopic-dermatitis
#5
Rafael Taeho Han, Seung Keun Back, Hyunkyoung Lee, JaeHee Lee, Hye Young Kim, Hee Jin Kim, Heung Sik Na
Atopic dermatitis is a complex disease of heterogeneous pathogenesis, in particular, genetic predisposition, environmental triggers, and their interactions. Indoor air pollution, increasing with urbanization, plays a role as environmental risk factor in the development of AD. However, we still lack a detailed picture of the role of air pollution in the development of the disease. Here, we examined the effect of formaldehyde (FA) exposure on the manifestation of atopic dermatitis and the underlying molecular mechanism in naive rats and in a rat model of atopic dermatitis (AD) produced by neonatal capsaicin treatment...
2016: PloS One
https://www.readbyqxmd.com/read/27996052/distinct-roles-of-short-and-long-thymic-stromal-lymphopoietin-isoforms-in-house-dust-mite-induced-asthmatic-airway-epithelial-barrier-disruption
#6
Hangming Dong, Yahui Hu, Laiyu Liu, Mengchen Zou, Chaowen Huang, Lishan Luo, Changhui Yu, Xuan Wan, Haijin Zhao, JiaLong Chen, Zhefan Xie, Yanqing Le, Fei Zou, Shaoxi Cai
Loss of airway epithelial integrity contributes significantly to asthma pathogenesis. Thymic stromal lymphopoietin (TSLP) may have dual immunoregulatory roles. In inflammatory disorders of the bowel, the long isoform of TSLP (lfTSLP) promotes inflammation while the short isoform (sfTSLP) inhibits inflammation. We hypothesize that lfTSLP contributes to house dust mite (HDM)-induced airway epithelial barrier dysfunction and that synthetic sfTSLP can prevent these effects. In vitro, airway epithelial barrier function was assessed by monitoring transepithelial electrical resistance, fluorescent-dextran permeability, and distribution of E-cadherin and β-catenin...
December 20, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27992078/basophils-and-mast-cells-are-crucial-for-reactions-due-to-epicutaneous-sensitization-to-ovalbumin
#7
Rie Yu, Ken Igawa, Yutaro Handa, Takichi Munetsugu, Takahiro Satoh, Hiroo Yokozeki
The prevalence of food allergies worldwide has increased recently. Epicutaneous sensitization to antigen could be a method to study food allergy METHODS: To clarify the mechanisms of food allergy, we established a mouse model of epicutaneous sensitization using ovalbumin. BALB/c mice were sensitized by three-time application of ovalbumin to tape-stripped skin (1-week sensitization at 2-week intervals) and oral challenge of ovalbumin undertaken. Rectal temperature was monitored. Blood and tissue (skin and jejunum) of challenged mice were taken...
December 19, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27984561/tslp-in-bacterial-skin-infection
#8
Laurie A Dempsey
No abstract text is available yet for this article.
December 16, 2016: Nature Immunology
https://www.readbyqxmd.com/read/27976427/effects-of-tslp-on-obstetrical-and-gynecological-diseases
#9
REVIEW
Yuan Zhang, Li-Ping Jin
Thymic stromal lymphopoietin (TSLP) is produced mainly by epithelial cells and was originally found to stimulate the growth and activation of B cells, but it is now shown to function on both hematopoietic and non-hematopoietic cell lineages. Despite a number of studies focusing on the role of TSLP in Th2 response for allergic disorders, it is becoming increasingly evident that TSLP may also be involved in multiple other disease states. This review will focus on recent advances on the effects of TSLP on obstetrical and gynecological diseases, including pregnancy failure, endometriosis, and cervical cancer...
January 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/27967302/cutaneous-exposure-to-clinically-relevant-pigeon-pea-cajanus-cajan-proteins-promote-th2-dependent-sensitization-and-ige-mediated-anaphylaxis-in-balb-c-mice
#10
Rinkesh Kumar Gupta, Sandeep Kumar, Kriti Gupta, Akanksha Sharma, Ruchi Roy, Alok Kumar Verma, Bhushan P Chaudhari, Mukul Das, Irfan Ahmad Ansari, Premendra D Dwivedi
Epicutaneous (EC) sensitization to food allergens may occur when the skin has been lightly damaged. The study here tested whether cutaneous exposure to pigeon pea protein(s) may cause allergic sensitization. BALB/c mice were either orally gavaged or epicutaneously sensitized by repeated application of pigeon pea crude protein extract (CPE) on undamaged areas of skin without any adjuvant; afterwards, both groups were orally challenged with the pigeon pea CPE. Anaphylactic symptoms along with measures of body temperature, MCPT-1, TSLP, pigeon pea-specific IgE and IgG1, myeloperoxidase (MPO) activity, TH2 cytokines, TH2 transcription factors (TFs) and filaggrin expression were determined...
November 2016: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/27942351/therapeutic-interventions-in-severe-asthma
#11
REVIEW
Giorgio Walter Canonica, Gianenrico Senna, Patrick D Mitchell, Paul M O'Byrne, Giovanni Passalacqua, Gilda Varricchi
The present paper addresses severe asthma which is limited to 5-10% of the overall population of asthmatics. However, it accounts for 50% or more of socials costs of the disease, as it is responsible for hospitalizations and Emergency Department accesses as well as expensive treatments. The recent identification of different endotypes of asthma, based on the inflammatory pattern, has led to the development of tailored treatments that target different inflammatory mediators. These are major achievements in the perspective of Precision Medicine: a leading approach to the modern treatment strategy...
2016: World Allergy Organization Journal
https://www.readbyqxmd.com/read/27941890/infection-tslp-complements-neutrophil-killing-of-bacteria
#12
Elisabeth Kugelberg
No abstract text is available yet for this article.
January 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/27924821/critical-role-of-tslp-responsive-mucosal-dendritic-cells-in-the-induction-of-nasal-antigen-specific-iga-response
#13
S Joo, Y Fukuyama, E J Park, Y Yuki, Y Kurashima, R Ouchida, S F Ziegler, H Kiyono
Thymic stromal lymphopoietin (TSLP) is an interleukin-7 (IL-7)-like cytokine involved in T helper 2 type immune responses. The primary target of TSLP is myeloid dendritic cells (DCs), however, little is known about the mechanism by which TSLP elicits respiratory IgA immune responses upon mucosal immunization. Here, we found that the levels of TSLP and TSLPR were upregulated in the mucosal DCs of mice nasally immunized with pneumococcal surface protein A (PspA) plus cholera toxin (CT) compared with those immunized with PspA alone...
December 7, 2016: Mucosal Immunology
https://www.readbyqxmd.com/read/27917896/astragaloside-iv-ameliorates-allergic-inflammation-by-inhibiting-key-initiating-factors-in-the-initial-stage-of-sensitization
#14
Kai-Fan Bao, Xi Yu, Xiao Wei, Li-Li Gui, Hai-Liang Liu, Xiao-Yu Wang, Yu Tao, Guo-Rong Jiang, Min Hong
To illuminate the anti-allergy mechanism of astragaloside IV (AS-IV), we assessed its effects in a murine model of allergic contact dermatitis (ACD). AS-IV administered in the sensitization phase, rather than in the elicitation phase, dramatically alleviated the symptoms of allergic inflammation. We hypothesized that AS-IV exerts its anti-allergy effects by regulating the production of key pro-allergic cytokines based on the fact that interleukin (IL)-33 and thymic stromal lymphopoietin (TSLP) levels increase significantly in the initial stage of the sensitization phase...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27913566/th2-responses-are-primed-by-skin-dendritic-cells-with-distinct-transcriptional-profiles
#15
Lisa M Connor, Shiau-Choot Tang, Emmanuelle Cognard, Sotaro Ochiai, Kerry L Hilligan, Samuel I Old, Christophe Pellefigues, Ruby F White, Deepa Patel, Adam Alexander T Smith, David A Eccles, Olivier Lamiable, Melanie J McConnell, Franca Ronchese
The dendritic cell signals required for the in vivo priming of IL-4-producing T cells are unknown. We used RNA sequencing to characterize DCs from skin LN of mice exposed to two different Th2 stimuli: the helminth parasite Nippostrongylus brasiliensis (Nb) and the contact sensitizer dibutyl phthalate (DBP)-FITC. Both Nb and DBP-FITC induced extensive transcriptional changes that involved multiple DC subsets. Surprisingly, these transcriptional changes were highly distinct in the two models, with only a small number of genes being similarly regulated in both conditions...
January 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27906425/the-correlation-between-children-s-status-asthmatics-and-interstitial-lung-disease
#16
X-M Han, Y-Y Cheng, Y-F Gong, M-M Jiang
OBJECTIVE: Investigating the correlation between children's status asthmatics and interstitial lung disease (ILD). PATIENTS AND METHODS: We continuously selected 20 cases of children's status asthmatics combined with ILD (group A), 20 cases of pure status asthmatics (group B), 20 cases of pure ILD (group C) and 20 cases of healthy children (group D). We measured Th1/Th2 by flow cytometry as well as the level of expression of hs-CRP, IL-7 cytokines (TSLP), monocyte chemoattractant protein-1 (MCP-1) and anti-Jo-1 antibody by ELISA method...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27902816/association-of-filaggrin-loss-of-function-and-thymic-stromal-lymphopoietin-variation-with-treatment-use-in-pediatric-atopic-dermatitis
#17
Joshua Chang, Nandita Mitra, Ole Hoffstad, David J Margolis
Importance: Atopic dermatitis (AD) is a common illness of childhood. Objective: To determine whether variations in FLG and TSLP genotype corresponded to differences in treatment use over time. Design, Setting, and Participants: This prospective cohort study recruited and followed a volunteer sample of 842 children enrolled in the Pediatric Eczema Elective Registry who provided saliva samples for DNA extraction for 10 years. Eligibility criteria included age 2 to 17 years, AD diagnosis without cancer, and prior pimecrolimus use...
November 30, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27889082/nod2-promotes-cell-proliferation-and-inflammatory-response-by-mediating-expression-of-tslp-in-human-airway-smooth-muscle-cells
#18
Gaoshun Ni, Yang Chen, Fengqin Wu, Pengxian Zhu, Liqiang Song
The newly discovered intracytosolic pattern recognition receptor nucleotide-binding oligomerization domain 2 (NOD2) has been studied as an important indicator of T helper 2 (Th2) inflammation, and its effect on regulatory T (Treg) cells is likely to modulate the immune response. In this study, we attempted to study the expression of NOD2 and its impact in human airway smooth muscle cells (HASMC). Quantitative real-time PCR (qRT-PCR) was used to measure the expression level of NOD2 in HASMC and comparisons were made between those from asthmatic and non-asthmatic donors; we found that NOD2 was significantly upregulated in asthma patient tissues and cell lines...
November 17, 2016: Cellular Immunology
https://www.readbyqxmd.com/read/27884591/toll-like-receptor-ligands-induce-cytokine-and-chemokine-production-in-human-inner-ear-endolymphatic-sac-fibroblasts
#19
Takechiyo Yamada, Kazuhiro Ogi, Masafumi Sakashita, Masafumi Kanno, Seita Kubo, Yumi Ito, Yoshimasa Imoto, Takahiro Tokunaga, Masayuki Okamoto, Norihiko Narita, Shigeharu Fujieda
OBJECTIVE: Against recent reports concerning cytokine or chemokine in mouse or rat inner ear cells, it is almost unknown whether human inner ear cells would produce cytokine or chemokine. We have for the first time established the human inner-ear-derived fibroblasts from endolymphatic sac. METHODS: The expression levels of Toll-like receptors (TLRs) in human endolymphatic sac fibroblasts, and the effect on cytokine or chemokine production of the TLR ligands have been examined...
November 21, 2016: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/27872753/multifunctional-thioredoxin-like-protein-from-the-gastrointestinal-parasitic-nematodes-strongyloides-ratti-and-trichuris-suis-affects-mucosal-homeostasis
#20
Dana Ditgen, Emmanuela M Anandarajah, Jan Hansmann, Dominic Winter, Guido Schramm, Klaus D Erttmann, Eva Liebau, Norbert W Brattig
The cellular redox state is important for the regulation of multiple functions and is essential for the maintenance of cellular homeostasis and antioxidant defense. In the excretory/secretory (E/S) products of Strongyloides ratti and Trichuris suis sequences for thioredoxin (Trx) and Trx-like protein (Trx-lp) were identified. To characterize the antioxidant Trx-lp and its interaction with the parasite's mucosal habitat, S. ratti and T. suis Trx-lps were cloned and recombinantly expressed. The primary antioxidative activity was assured by reduction of insulin and IgM...
2016: Journal of Parasitology Research
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