Natalia Alkon, Frank P Assen, Tamara Arnoldner, Wolfgang M Bauer, Marco A Medjimorec, Lisa E Shaw, Katharina Rindler, Gregor Holzer, Philipp Weber, Wolfgang Weninger, Christian Freystätter, Sumanth Chennareddy, Tamar Kinaciyan, Matthias Farlik, Constanze Jonak, Johannes Griss, Christine Bangert, Patrick M Brunner
BACKGROUND: Chronic nodular prurigo (CNPG) is a chronic inflammatory skin disease that is maintained by a chronic itch-scratch cycle likely rooted in neuro-immunological dysregulation. This condition may be associated with atopy in some patients, and there are now promising therapeutic results from blocking type-2 cytokines such as IL-4, IL-13 and IL-31. Nevertheless, underlying pathomechanisms as well as the molecular relationship with atopy remain ill-defined. METHODS: We profiled skin lesions from patients with CNPG in comparison to atopic dermatitis (AD) and healthy control (HC) individuals using single-cell RNA sequencing combined with T-cell receptor sequencing...
May 18, 2023: Journal of Allergy and Clinical Immunology