keyword
MENU ▼
Read by QxMD icon Read
search

IL-33

keyword
https://www.readbyqxmd.com/read/28067797/unconventional-pathways-of-secretion-contribute-to-inflammation
#1
REVIEW
Michael J D Daniels, David Brough
In the conventional pathway of protein secretion, leader sequence-containing proteins leave the cell following processing through the endoplasmic reticulum (ER) and Golgi body. However, leaderless proteins also enter the extracellular space through mechanisms collectively known as unconventional secretion. Unconventionally secreted proteins often have vital roles in cell and organism function such as inflammation. Amongst the best-studied inflammatory unconventionally secreted proteins are interleukin (IL)-1β, IL-1α, IL-33 and high-mobility group box 1 (HMGB1)...
January 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28063044/characterization-of-group-2-innate-lymphoid-cells-in-allergic-airway-inflammation-models-in-the-mouse
#2
Bobby W S Li, Dior M J M Beerens, Maarten D Brem, Rudi W Hendriks
Allergic asthma is a chronic inflammatory lung disease mediated by type 2 cytokines produced by T helper 2 (Th2) cells as well as the recently discovered group 2 innate lymphoid cells (ILC2). Due to a lack of unique markers, the accurate phenotypic characterization and quantification of ILC2 requires a comprehensive panel of fluorescently labeled antibodies. The markers that are currently used to characterize ILC2 have not been standardized and often vary between research groups, which poses significant challenges when comparing data...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28063040/a-mouse-model-for-atopic-dermatitis-using-topical-application-of-vitamin-d3-or-of-its-analog-mc903
#3
Verena Moosbrugger-Martinz, Matthias Schmuth, Sandrine Dubrac
Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disease with pruritus and high prevalence. Indeed, 15-30 % of children and 2-10 % of adults from industrialized countries are affected. Acute AD lesions are characterized by epidermal hyperplasia associated with a dominant Th2/Th17 immune response and dermal inflammatory infiltrates. Moreover, the expression of alarmins such as TSLP, IL-33, and IL-25 is upregulated in acute AD lesions. Topical application of vitamin D3 or of its low-calcemic analog MC903 induces changes in skin morphology and inflammation resembling immune perturbations observed in acute lesions of patients with AD...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28058630/il-33-acts-as-a-foe-to-mia-paca-2-pancreatic-cancer
#4
Yujiang Fang, Lei Zhao, Huaping Xiao, Kathryn M Cook, Qian Bai, Elizabeth J Herrick, Xuhui Chen, Chenglu Qin, Ziwen Zhu, Mark R Wakefield, Michael B Nicholl
IL-33 is a member of the IL-1 family of cytokines, and no study has been performed to address its direct anti-tumor effect. This study is designed to investigate whether IL-33 has any direct effect on pancreatic cancer. Clonogenic survival assay, immunohistochemistry, TUNEL staining, proliferation, caspase-3 activity kits and RT-PCR were used to evaluate the effects of IL-33 on cell survival, proliferation and apoptosis of a pancreatic cancer cell line, MIA PaCa-2. We found that the percentage of colonies of MIA PaCa-2 cells, PCNA+ cells and the OD value of cancer cells were all decreased in the presence of IL-33...
February 2017: Medical Oncology
https://www.readbyqxmd.com/read/28053237/highly-selective-cleavage-of-cytokines-and-chemokines-by-the-human-mast-cell-chymase-and-neutrophil-cathepsin-g
#5
Zhirong Fu, Michael Thorpe, Rahel Alemayehu, Ananya Roy, Jukka Kervinen, Lawrence de Garavilla, Magnus Åbrink, Lars Hellman
Human mast cell chymase (HC) and human neutrophil cathepsin G (hCG) show relatively similar cleavage specificities: they both have chymotryptic activity but can also cleave efficiently after leucine. Their relatively broad specificity suggests that they may cleave almost any substrate if present in high enough concentrations or for a sufficiently long time. A number of potential substrates have been identified for these enzymes and, recently, these enzymes have also been implicated in regulating cytokine activity by cleaving numerous cytokines and chemokines...
January 4, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28051120/erratum-il-33-contributes-to-schistosoma-japonicum-induced-hepatic-pathology-through-induction-of-m2-macrophages
#6
Hui Peng, Qixian Zhang, Xiaojuan Li, Zhen Liu, Jia Shen, Rui Sun, Jie Wei, Jia Zhao, Xiaoying Wu, Feng Feng, Shuping Zhong, Xi Sun, Zhongdao Wu
No abstract text is available yet for this article.
January 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28049868/expression-of-epithelial-cell-derived-cytokine-genes-in-the-duodenal-and-colonic-mucosae-of-dogs-with-chronic-enteropathy
#7
Hironari Osada, Misato Ogawa, Ayana Hasegawa, Makoto Nagai, Junsuke Shirai, Kazuaki Sasaki, Minoru Shimoda, Hiroshi Itoh, Hirotaka Kondo, Keitaro Ohmori
It remains unclear whether epithelial cell-derived cytokines, including interleukin (IL)-25, IL-33 and thymic stromal lymphopoietin (TSLP), contribute to development of canine chronic enteropathy (CE), which includes antibiotic-responsive enteropathy (ARE), food-responsive enteropathy (FRE) and inflammatory bowel disease (IBD). In the present study, we examined mRNA expression of il-25, il-33 and tslp in the duodenal and colonic mucosae of dogs with ARE, FRE and IBD. Real-time PCR analysis revealed that mRNA expression of il-33 was significantly lower in the duodenum in dogs with FRE than in healthy dogs...
December 29, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28045954/the-rs7044343-polymorphism-of-the-interleukin-33-gene-is-associated-with-decreased-risk-of-developing-premature-coronary-artery-disease-and-central-obesity-and-could-be-involved-in-regulating-the-production-of-il-33
#8
Javier Angeles-Martínez, Rosalinda Posadas-Sánchez, Luis Llorente, Edith Alvarez-León, Julian Ramírez-Bello, Teresa Villarreal-Molina, Guadalupe Lima, Guillermo Cardoso-Saldaña, José Manuel Rodríguez-Pérez, Nonanzit Pérez-Hernández, José Manuel Fragoso, Carlos Posadas-Romero, Gilberto Vargas-Alarcón
AIM: The effect of interleukin 33 (IL-33) in the inflammatory process generates significant interest in the potential significance of IL-33 as a biomarker for coronary artery disease (CAD). Here, our objective was to analyze whether IL-33 gene polymorphisms are associated with premature CAD in a case-control association study. METHODS: Four IL-33 polymorphisms (rs7848215, rs16924144, rs16924159 and rs7044343) were genotyped by 5' exonuclease TaqMan assays in 1095 patients with premature CAD and 1118 controls...
2017: PloS One
https://www.readbyqxmd.com/read/28044058/allergy-neonatal-il-33-drives-allergy
#9
Lydia Shipman
No abstract text is available yet for this article.
January 3, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28041873/il-33-enhances-macrophage-m2-polarization-and-protects-mice-from-cvb3-induced-viral-myocarditis
#10
Chao Wang, Chunsheng Dong, Sidong Xiong
Viral myocarditis is the inflammation caused by myocardial virus infection, and the coxsackievirus group B3 virus (CVB3) is the most common pathogen. An efficient therapeutic agent against viral myocarditis is currently unavailable. IL-33, a new member of the IL-1 cytokine superfamily, exhibits potential immunotherapeutic effect against inflammatory and autoimmune diseases. However, the functional role of IL-33 in viral myocarditis has not been investigated. To examine the therapeutic role of IL-33 in viral myocarditis, an IL-33 overexpression plasmid (pDisplay-IL-33) and IL-33 knockdown plasmid (pLL3...
December 29, 2016: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28034545/comparison-of-lung-damage-in-mice-exposed-to-black-carbon-particles-and-1-4-naphthoquinone-coated-black-carbon-particles
#11
Hongqian Chu, Jing Shang, Ming Jin, Yueyue Chen, Yao Pan, Yuan Li, Xi Tao, Zhiyuan Cheng, Qinghe Meng, Qian Li, Guang Jia, Tong Zhu, Weidong Hao, Xuetao Wei
Black carbon (BC) is a key component of atmospheric particles and has a significant effect on human health. BC can provide reactive sites and surfaces thus absorb quinones which were primarily generated from fossil fuel combustion and/or atmospheric photochemical conversions of PAHs. Oxidation could change the characteristics of BC and increase its toxicity. The comparison of lung damage in mice exposed to BC and 1,4-NQ-coated BC (1,4NQ-BC) particles is investigated in this study. Mice which were intratracheally instilled with particles have a higher expression of IL-1β, IL-6 and IL-33 in bronchoalveolar lavage fluid (BALF)...
December 26, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/28017833/protein-palmitoylation-by-zdhhc13-protects-skin-against-microbial-driven-dermatitis
#12
Li-Ying Chen, Hsin-Fang Yang-Yen, Chun-Chou Tsai, Christina Li-Ping Thio, Hsiao-Li Chuang, Liang-Tung Yang, Li-Fen Shen, I-Wen Song, Kai-Ming Liu, Yen-Te Huang, Fu-Tong Liu, Ya-Jen Chang, Yuan-Tsong Chen, Jeffrey J Y Yen
Atopic dermatitis (AD) is a complex chronic inflammatory skin disorder that results from intimate interactions between genetic predisposition, host environment, skin barrier defects, and immunological factors. However, a clear genetic roadmap leading to AD remains to be fully explored. From a genome-wide mutagenesis screen, deficiency of ZDHHC13, a palmitoylacyl transferase, has previously been associated with skin and multi-tissue inflammatory phenotypes. Here, we report that ZDHHC13 is required for skin barrier integrity and that deficiency of ZDHHC13 renders mice susceptible to environmental bacteria, resulting in persistent skin inflammation and an AD-like disease...
December 22, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28013014/metabolic-complications-precede-alloreactivity-and-are-characterized-by-changes-in-st2-signaling
#13
Romany A N Johnpulle, Sophie Paczesny, Dae Kwang Jung, Etienne Daguindau, Madan H Jagasia, Bipin N Savani, Wichai Chinratanalab, Robert F Cornell, Stacey Goodman, John P Greer, Adetola A Kassim, Salyka Sengsayadeth, Michael T Byrne, Brian G Engelhardt
New-onset post-transplant diabetes mellitus (PTDM) occurs commonly after allogeneic hematopoietic cell transplantation (HCT) and is associated with inferior survival. We hypothesize that PTDM and non-relapse mortality (NRM) are related to IL-33/suppression of tumorigenicity 2 (ST2) signaling and that soluble ST2 (sST2) levels will predict PTDM diagnosis. sST2 was measured at engraftment and day+30 in 36 euglycemic HCT recipients followed prospectively for PTDM (cohort 1). Results were confirmed in a validation cohort of 26 patients without pre-existing diabetes retrospectively analyzed for PTDM (cohort 2)...
December 21, 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28011934/exogenous-il-33-restores-dendritic-cell-activation-and-maturation-in-established-cancer
#14
Donye Dominguez, Cong Ye, Zhe Geng, Siqi Chen, Jie Fan, Lei Qin, Alan Long, Long Wang, Zhuoli Zhang, Yi Zhang, Deyu Fang, Timothy M Kuzel, Bin Zhang
The role of IL-33, particularly in tumor growth and tumor immunity, remains ill-defined. We show that exogenous IL-33 can induce robust antitumor effect through a CD8(+) T cell-dependent mechanism. Systemic administration of rIL-33 alone was sufficient to inhibit growth of established tumors in transplant and de novo melanoma tumorigenesis models. Notably, in addition to a direct action on CD8(+) T cell expansion and IFN-γ production, rIL-33 therapy activated myeloid dendritic cells (mDCs) in tumor-bearing mice, restored antitumor T cell activity, and increased Ag cross-presentation within the tumor microenvironment...
December 23, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28011865/leukotrienes-provide-an-nfat-dependent-signal-that-synergizes-with-il-33-to-activate-ilc2s
#15
Jakob von Moltke, Claire E O'Leary, Nora A Barrett, Yoshihide Kanaoka, K Frank Austen, Richard M Locksley
Group 2 innate lymphoid cells (ILC2s) and type 2 helper T cells (Th2 cells) are the primary source of interleukin 5 (IL-5) and IL-13 during type 2 (allergic) inflammation in the lung. In Th2 cells, T cell receptor (TCR) signaling activates the transcription factors nuclear factor of activated T cells (NFAT), nuclear factor κB (NF-κB), and activator protein 1 (AP-1) to induce type 2 cytokines. ILC2s lack a TCR and respond instead to locally produced cytokines such as IL-33. Although IL-33 induces AP-1 and NF-κB, NFAT signaling has not been described in ILC2s...
January 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28002727/allergen-exposure-when-timing-is-everything
#16
Tanel Mahlakõiv, David Artis
It is known that young children exposed to allergens are prone to develop asthma later in life. In this issue of Immunity, de Kleer et al. (2016) identify IL-33 as a key player in the developing lung for sensitization to environmental allergens and airway hyperreactivity.
December 20, 2016: Immunity
https://www.readbyqxmd.com/read/28000059/interleukin-33-expression-does-not-correlate-with-survival-of-gastric-cancer-patients
#17
Wenwei Hu, Xiaodong Li, Qing Li, Yan Tan, Bin Xu, Quanqin Xie, Xu Deng, Binfeng Lu, Jingting Jiang, Changping Wu
The aim of the study was to investigate IL-33 expression in gastric cancer (GC) and its association with the clinical characteristics and the prognosis. IL-33 protein in tumor and corresponding adjacent tissues were detected by immunohistochemistry in 179 GC patients and clinical features plus prognostic value were analyzed via Pearson's chi-square test and Kaplan-Meier test in Cox proportional hazards model, respectively. IL-33 protein levels were significantly lower in tumor tissues than adjacent tissues (29...
December 20, 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/27994070/characterization-of-meningeal-type-2-innate-lymphocytes-and-their-response-to-cns-injury
#18
Sachin P Gadani, Igor Smirnov, Ashtyn T Smith, Christopher C Overall, Jonathan Kipnis
The meningeal space is occupied by a diverse repertoire of immune cells. Central nervous system (CNS) injury elicits a rapid immune response that affects neuronal survival and recovery, but the role of meningeal inflammation remains poorly understood. Here, we describe type 2 innate lymphocytes (ILC2s) as a novel cell type resident in the healthy meninges that are activated after CNS injury. ILC2s are present throughout the naive mouse meninges, though are concentrated around the dural sinuses, and have a unique transcriptional profile...
December 19, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27992569/interleukin-33-and-rank-l-interplay-in-the-alveolar-bone-loss-associated-to-periodontitis
#19
Olivier Lapérine, Alexandra Cloitre, Jocelyne Caillon, Olivier Huck, Isaac Maximiliano Bugueno, Paul Pilet, Sophie Sourice, Elodie Le Tilly, Gaby Palmer, Jean-Luc Davideau, Valérie Geoffroy, Jérôme Guicheux, Sarah Beck-Cormier, Philippe Lesclous
INTRODUCTION: Chronic Periodontitis (CP) is an inflammatory disease of bacterial origin that results in alveolar bone destruction. Porphyromonas gingivalis (Pg), one of the main periopathogens, initiates an inflammatory cascade by host immune cells thereby increasing recruitment and activity of osteoclasts, the bone resorbing cells, through enhanced production of the crucial osteoclastogenic factor, RANK-L. Antibodies directed against some cytokines (IL-1β, IL-6 and TNF-α) failed to exhibit convincing therapeutic effect in CP...
2016: PloS One
https://www.readbyqxmd.com/read/27989898/inflammation-elevated-il-33-originating-from-the-lung-mediates-inflammation-in-acute-lung-injury
#20
Shi-Hui Lin, Juan Fu, Chuan-Jiang Wang, Feng Gao, Xuan-Yun Feng, Qiong Liu, Ju Cao, Fang Xu
Excessive inflammatory reactions occur with acute respiratory distress syndrome (ARDS), however, the underlying mechanisms of ARDS remain incompletely understood. Here we investigated whether interleukin (IL)-33 was elevated in ARDS patients. Serum samples were obtained from 14 ARDS patients and 24 control healthy volunteers. ELISA was used to measure the concentrations of IL-33. Besides, we established pulmonary ARDS and extrapulmonary ARDS models in mice, and serum and lung tissue samples were collected for analyses...
October 28, 2016: Clinical Immunology: the Official Journal of the Clinical Immunology Society
keyword
keyword
12332
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"