Kimberley R Kaspy, Sharon D Dell, Stephanie D Davis, Thomas W Ferkol, Margaret Rosenfeld, Scott D Sagel, Carlos Milla, Kenneth N Olivier, Andrew T Barber, Wallace Wee, Feng-Chang Lin, Lang Li, Emmanouil Rampakakis, Maimoona A Zariwala, Michael R Knowles, Margaret W Leigh, Adam J Shapiro
BACKGROUND: Primary ciliary dyskinesia (PCD) is a rare disorder of motile cilia associated with situs abnormalities. At least 12% of patients with PCD have situs ambiguus (SA), including organ laterality defects falling outside normal arrangement [situs solitus (SS)] or mirror image inversion [situs inversus totalis (SIT)]. RESEARCH QUESTION: Do patients with PCD and SA have worse clinical outcomes compared to those with SS or SIT? STUDY DESIGN AND METHODS: This cross-sectional, multicenter study evaluated participants ≤21 years with PCD...
December 8, 2023: Chest