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https://www.readbyqxmd.com/read/28081350/the-effect-of-systemic-isotretinoin-treatment-on-skin-biophysicalparameters-among-patients-with-acne-vulgaris
#1
Emine Çölgeçen, Kemal Özyurt, Ayten Ferahbaş Kesikoğlu
BACKGROUND/AIM: Systemic isotretinoin has been widely considered an effective and safe medical treatment for severe and refractory acne for nearly 3 decades. However, it also appears to cause undesirable cutaneous side effects. The aim of this study was to prospectively measure biophysical parameters of skin function among patients with acne vulgaris before and after 3 months of isotretinoin therapy, including pH, temperature, sebum content, skin hydration, and transepidermal water loss...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28081151/human-lacrimal-gland-gene-expression
#2
Vinay Kumar Aakalu, Sowmya Parameswaran, Mark Maienschein-Cline, Neil Bahroos, Dhara Shah, Marwan Ali, Subramanian Krishnakumar
BACKGROUND: The study of human lacrimal gland biology and development is limited. Lacrimal gland tissue is damaged or poorly functional in a number of disease states including dry eye disease. Development of cell based therapies for lacrimal gland diseases requires a better understanding of the gene expression and signaling pathways in lacrimal gland. Differential gene expression analysis between lacrimal gland and other embryologically similar tissues may be helpful in furthering our understanding of lacrimal gland development...
2017: PloS One
https://www.readbyqxmd.com/read/28079852/ichthyosiform-sarcoidosis-report-of-three-cases-from-japan-and-literature-review
#3
Takako Miura, Yasunobu Kato, Toshiyuki Yamamoto
Cutaneous lesions of sarcoidosis present with various manifestations including specific and non-specific cutaneous lesions. Ichthyosiform sarcoidosis is a rare form of cutaneous sarcoidosis, presenting with asymptomatic, adherent, polygonal scales, mainly appearing on the lower limbs.  Ichthyosiform sarcoidosis has a predilection for dark-skinned races, and cases affecting Japanese patients have rarely been reported in English literature.  We herein describe three Japanese cases of ichthyosiform sarcoidosis on the lower limbs...
December 23, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
https://www.readbyqxmd.com/read/28078772/skin-cleansing-and-emolliating-for-older-people-a-quasi-experimental-pilot-study
#4
Jill Brooks, Fiona Cowdell, Steven J Ersser, Eric D Gardiner
AIMS: The aims of this study were to (i) assess the effect of low-cost hygiene and emollient regimens on the skin barrier function (SBF) of people aged >65 year with xerosis (dry skin) on their lower legs; (ii) to assess the utility of portable measures of skin barrier function in terms of stratum corneum hydration (SCH) and transepidermal water loss (TEWL) in community settings; and iii) to provide evidence for a randomised controlled trial on the treatment of adults in a resource-poor country with dry skin on their lower legs which causes and exacerbates the skin disease podoconiosis (non-filarial elephantiasis)...
January 12, 2017: International Journal of Older People Nursing
https://www.readbyqxmd.com/read/28070050/-clinical-comparative-analysis-for-pulmonary-histoplasmosis-and-progressive-disseminated-histoplasmosis
#5
Yan Zhang, Xiaoli Su, Yuanyuan Li, Ruoxi He, Chengping Hu, Pinhua Pan
To compare clinical features, diagnosis and therapeutic effect between pulmonary histoplasmosis and progressive disseminated histoplasmosis.
 Methods: A retrospective analysis for 12 cases of hospitalized patients with histoplasmosis, who was admitted in Xiangya Hospital, Central South University during the time from February 2009 to October 2015, was carried out. Four cases of pulmonary histoplasmosis and 8 cases of progressive disseminated histoplasmosis were included. The differences of clinical features, imaging tests, means for diagnosis and prognosis were analyzed between the two types of histoplasmosis...
December 28, 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28067963/wetting-and-adhesion-evaluation-of-cosmetic-ingredients-and-products-correlation-of-in-vitro-in-vivo-contact-angle-measurements
#6
P Capra, G Musitelli, P Perugini
OBJECTIVE: The aim of this work was to use the contact angle measurement in order to predict the behavior of ingredients and finished cosmetic products on skin to improve skin feel and product texture. METHOD: Different classes of cosmetic ingredients and formulations were evaluated. The contact angle measurements were carried out by the sessile drop methodusing an apparatus, designed and set up in laboratory. Glass, Teflon and human skin were the reference substrates...
January 9, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/28056322/-the-therapeutic-value-and-safety-of-icotinib-as-first-line-therapy-for-advanced-non-small-cell-lung-cancer-patients
#7
H Chen, H P Wang, L Zhang, X Y Si
Objective: To evaluate the safety and efficacy of icotinib as first-line therapy in Chinese non-small cell lung cancer (NSCLC) patients harboring epidermal growth factor receptor (EGFR) sensitive mutations. Methods: Patients with stage ⅢB/Ⅳ NSCLC who had EGFR sensitive mutation and had no previous treatment were enrolled into this study. The response rates, progress free survival (PFS), overall survival (OS), and the safety were analyzed. Results: Ninety advanced adenocarcinoma patients were enrolled in this study, 44 patients had partial response (PR), 42 patients had stable disease (SD), 4 patients had progressive disease (PD), with an overall response rate (ORR) of 48...
January 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/28050051/discordant-dry-eye-disease-an-american-ophthalmological-society-thesis
#8
Roni M Shtein, Daniel E Harper, Vincent Pallazola, Steven E Harte, Munira Hussain, Alan Sugar, David A Williams, Daniel J Clauw
PURPOSE: To improve understanding of dry eye disease and highlight a subgroup of patients who have a component of central sensitization and neuropathic pain contributing to their condition. METHODS: Prospective, cross-sectional, IRB-approved study comparing isolated dry eye disease (n=48) to fibromyalgia (positive control; n=23) and healthy (negative control; n=26) individuals with ocular surface examination, corneal confocal microscopy, quantitative sensory testing, and self-reported ocular symptoms and systemic associations...
August 2016: Transactions of the American Ophthalmological Society
https://www.readbyqxmd.com/read/28047900/su-f-t-379-dosimetric-impacts-of-topical-agents-and-dressings-on-skin-in-radiotherapy
#9
K Tse, L Morley, A Cashell, A Sperduti, M McQuestion, J Chow
PURPOSE: This study investigated the superficial dose enhancement in the application of topical agents, clinical materials (thermal mask and bolus) and dressings in megavoltage photon beam radiotherapy. Different topical skin agents, clinical materials and dressings were evaluated and compared for their skin dosimetric impacts on the patients during radiation treatment. METHODS: Superficial dose enhancements, or percentage doses with and without the studying materials, were measured using the 6 MV (Field size = 10×10 cm(2) ) photon beams produced by a Varian TrueBeam linear accelerator...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28034767/interruption-of-the-transmission-of-onchocerca-volvulus-in-the-kashoya-kitomi-focus-western-uganda-by-long-term-ivermectin-treatment-and-elimination-of-the-vector-simulium-neavei-by-larviciding
#10
T Lakwo, R Garms, J Wamani, E M Tukahebwa, E Byamukama, A W Onapa, E Tukesiga, J Katamanywa, S Begumisa, P Habomugisha, D Oguttu, E Byamukama, F Richards, T R Unnasch, M Katabarwa
Uganda is the only country in sub-Saharan Africa whose onchocerciasis elimination programme extensively uses vector control and biannual treatment with ivermectin. The purpose of this study was to assess the impact of combined strategies on interrupting onchocerciasis transmission in the Kashoya-Kitomi focus. Mass Drug Administration annually (13 years) followed by biannual treatments (6 years) and ground larviciding (36 cycles in 3 years) with temephos (Abate(®), EC500) against Simulium neavei were conducted...
December 26, 2016: Acta Tropica
https://www.readbyqxmd.com/read/28025545/the-pathogenetic-effect-of-natural-and-bacterial-toxins-on-atopic-dermatitis
#11
REVIEW
Kyung-Duck Park, Sok Cheon Pak, Kwan-Kyu Park
Atopic dermatitis (AD) is a common allergic skin disease that is associated with chronic, recurrent eczematous and pruritic lesions at the flexural folds caused by interacting factors related to environmental and immune system changes. AD results in dry skin, and immunoglobulin E-mediated allergic reactions to foods and environmental allergens. While steroids and anti-histamines temporarily relieve the symptoms of AD, the possibility of side effects from pharmacological interventions remains. Despite intensive research, the underlying mechanisms for AD have not been clarified...
December 23, 2016: Toxins
https://www.readbyqxmd.com/read/28002684/effects-of-caffeine-on-endurance-capacity-and-psychological-state-in-young-females-and-males-exercising-in-the-heat
#12
Silva Suvi, Saima Timpmann, Maria Tamm, Martin Aedma, Kairi Kreegipuu, Vahur Ööpik
Acute caffeine ingestion is considered effective in improving endurance capacity and psychological state. However, current knowledge is based on the findings of studies that have been conducted on male subjects mainly in temperate environmental conditions, but some physiological and psychological effects of caffeine differ between the sexes. The purpose of this study was to compare the physical performance and psychological effects of caffeine in young women and men exercising in the heat. Thirteen male and 10 female students completed 2 constant-load walks (60% of thermoneutral peak oxygen consumption on a treadmill until volitional exhaustion) in a hot-dry environment (air temperature, 42 °C; relative humidity, 20%) after caffeine (6 mg·kg(-1)) and placebo (wheat flour) ingestion in a double-blind, randomly assigned, crossover manner...
January 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/27998274/repressed-sirt1-pgc-1%C3%AE-pathway-and-mitochondrial-disintegration-in-ipsc-derived-rpe-disease-model-of-age-related-macular-degeneration
#13
Nady Golestaneh, Yi Chu, Shuk Kei Cheng, Hong Cao, Eugenia Poliakov, Daniel M Berinstein
BACKGROUND: Study of age related macular degeneration (AMD) has been hampered by lack of human models that represent the complexity of the disease. Here we have developed a human in vitro disease model of AMD to investigate the underlying AMD disease mechanisms. METHODS: Generation of iPSCs from retinal pigment epithelium (RPE) of AMD donors, age-matched normal donors, skin fibroblasts of a dry AMD patient, and differentiation of iPSCs into RPE (AMD RPE-iPSC-RPE, normal RPE-iPSC-RPE and AMD Skin-iPSC-RPE, respectively)...
December 20, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27983740/efficacy-of-body-lotion-containing-n-palmitoylethanolamine-in-subjects-with-chronic-pruritus-due-to-dry-skin-a-dermatocosmetic-study
#14
Katharina Visse, Christine Blome, Ngoc Quan Phan, Matthias Augustin, Sonja Ständer
is missing (Short Communication).
December 16, 2016: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/27981754/identification-of-predominant-phytochemical-compounds-and-cytotoxic-activity-of-wild-olive-leaves-olea-europaea-l-ssp-sylvestris-harvested-in-south-portugal
#15
Justyna Makowska-Wąs, Agnieszka Galanty, Joanna Gdula-Argasińska, Małgorzata Tyszka-Czochara, Agnieszka Szewczyk, Ricardo Nunes, Isabel de Carvalho, Marta Michalik, Paweł Paśko
This study has been aimed at providing a qualitative and quantitative evaluation of selected phytochemicals such as phenolic acids, flavonoids, oleuropein, fatty acids profile, and volatile oil compounds, present in wild olive leaves harvested in Portugal, as well as at determining their antioxidant and cytotoxic potential against human melanoma HTB-140 and WM793, prostate cancer DU-145 and PC-3, hepatocellular carcinoma Hep G2 cell lines, as well as normal human skin fibroblasts BJ and prostate epithelial cells PNT2...
December 16, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27978460/clinical-characteristics-of-headache-or-facial-pain-prior-to-the-development-of-acute-herpes-zoster-of-the-head
#16
Hye Lim Lee, Minju Yeo, Gi Hwa Choi, Ji Yeoun Lee, Ji Seon Kim, Dong-Ick Shin, Sang-Soo Lee, Sung-Hyun Lee
OBJECTIVES: When physicians encounter patients with headache or facial pain (preeruptive pain) associated with acute herpes zoster of the head, especially before the appearance of characteristic skin eruptions (preeruptive phase), they typically find it difficult to make clinical impressions and apply appropriate diagnostic or therapeutic procedures. The objectives of this study were to describe the clinical characteristics of headache or facial pain associated with acute herpes zoster of the head and to elucidate the association between the manifestation of these symptoms in the preeruptive phase and incoming herpes zoster...
January 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27977487/anatomical-study-and-locating-nasolacrimal-duct-on-computed-topographic-image
#17
Siwen Zhang, Ye Cheng, Jianan Xie, Zhengmin Wang, Fan Zhang, Longquan Chen, Yan Feng, Guixia Wang
PURPOSE: We performed a novel anatomical and radiological investigation to understand the structure of nasolacrimal duct (NLD) and to provide data to help surgeons locate the openings of NLD efficiently based on landmarks. MATERIALS AND METHODS: We examined the NLD region using computed tomography images of 133 individuals and 6 dry skull specimens. Multiplanar reconstruction of the computed tomography images was performed, and the anatomical features of the NLD were studied in the coronal, sagittal, and axial planes...
December 12, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27976363/acute-skin-and-hair-symptoms-followed-by-severe-delayed-eye-complications-in-subjects-using-the-synthetic-opioid-mt-45
#18
A Helander, M Bradley, A Hasselblad, L Norlén, I Vassilaki, M Bäckberg, J Lapins
BACKGROUND: The introduction of unclassified new psychoactive substances (NPS) on the recreational drugs market through open online sale ('legal highs' or 'Internet drugs') continues unabated and represents a growing health hazard. The use of NPS has resulted in numerous, severe, adverse events and fatalities, due to unintended overdose or unknown toxic side-effects. OBJECTIVES: To try to find a possible common underlying cause for the skin-hair-eye symptoms complex observed in three men...
December 14, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27974010/outcomes-of-acute-dermal-irritation-and-sensitisation-tests-on-active-dressings-for-chronic-wounds-a-comparative-study
#19
P J Zelga, M M Górnicz, J M Głuszkiewicz, J Piasecka-Zelga
OBJECTIVE: Chronic, non-healing ulcers are a significant problem in clinical practice. The numerous complications, associated with toxicological and allergic reactions, caused by certain compounds in active dressings have been reported. The aim of this study was to evaluate the local skin tolerance of active dressings and determine which of them carries a risk of causing local skin reactions. METHOD: We tested six active dressings from different categories (hydrogel dressing, chitosan sponge dressing, silver nanoparticles dressing, dry flax fibres dressing alone and coated with linfix or oilfix) for acute irritation in rabbits and for sensitisation in guinea pigs...
December 2, 2016: Journal of Wound Care
https://www.readbyqxmd.com/read/27966600/gene-network-analysis-identifies-rumen-epithelial-cell-proliferation-differentiation-and-metabolic-pathways-perturbed-by-diet-and-correlated-with-methane-production
#20
Ruidong Xiang, Jody McNally, Suzanne Rowe, Arjan Jonker, Cesar S Pinares-Patino, V Hutton Oddy, Phil E Vercoe, John C McEwan, Brian P Dalrymple
Ruminants obtain nutrients from microbial fermentation of plant material, primarily in their rumen, a multilayered forestomach. How the different layers of the rumen wall respond to diet and influence microbial fermentation, and how these process are regulated, is not well understood. Gene expression correlation networks were constructed from full thickness rumen wall transcriptomes of 24 sheep fed two different amounts and qualities of a forage and measured for methane production. The network contained two major negatively correlated gene sub-networks predominantly representing the epithelial and muscle layers of the rumen wall...
December 14, 2016: Scientific Reports
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