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https://www.readbyqxmd.com/read/28314226/long-term-follow-up-of-mucous-membrane-grafting-for-cicatricial-ectropion-in-ichthyosis-a-case-report
#1
Hind Manaa Alkatan, Manar A Aljebreen, Adel H Alsuhaibani
INTRODUCTION: Ichthyosis is a group of keratinizing diseases characterized by scaly and dry skin. One of the ocular complications associated with ichthyosis is cicatricial ectropion which often results in exposure keratopathy and eventually corneal scarring. PRESENTATION OF CASE: In this report we are presenting a 21-year-old female who is known to have ichthyosis-related bilateral lower lid cicatricial ectropion, which was managed with Mucous Membrane Grafting (MMG) six years ago...
February 16, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28302098/in-vivo-confocal-microscopy-of-pre-descemet-corneal-dystrophy-associated-with-x-linked-ichthyosis-a-case-report
#2
Hui Shi, Xiao-Feng Qi, Tao-Tao Liu, Qian Hao, Xiao-Hong Li, Ling-Ling Liang, Yi-Miao Wang, Zhi-Hua Cui
BACKGROUND: Pre-Descemet corneal dystrophy (PDCD) is characterized by the presence of numerous, tiny, polymorphic opacities immediately anterior to Descemet membrane, which is a rare form of corneal stromal dystrophy and hard to be diagnosed. In vivo confocal microscopy (IVCM) is a useful tool to examine the minimal lesions of the cornea at the cellular level. In this article, we report a rare case of PDCD associated with X-linked ichthyosis and evaluate IVCM findings. CASE PRESENTATION: We present a 34-year-old male Chinese patient with PDCD associated with X-linked ichthyosis...
March 16, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28301620/anti-pruritic-efficacy-of-itch-relief-lotion-and-cream-in-patients-with-atopic-history-comparison-with-hydrocortisone-cream
#3
Matthew J Zirwas, Sylvia Barkovic
<p>Objective: To evaluate the speed of onset and duration of relief of two ceramide-containing formulations with 1% pramoxine hydroxide (CeraVe® Itch Relief Lotion and Cream,Valeant Pharmaceuticals North America LLC, Irvine, CA) in patients with atopic history, including those with active flare and the comparative efficacy of CeraVe Itch Relief Cream to hydrocortisone 1% cream and night-time itch relief with continued use. METHODS: Two double-blind, split-body, randomized studies in 66 male and female subjects, ages 11+ years, with history of atopic dermatitis (AD)...
March 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28300856/halobetasol-propionate-lotion-0-05-provides-superior-hydration-compared-to-halobetasol-propionate-cream-0-05-in-a-double-blinded-study-of-occlusivity-and-hydration
#4
Gary Grove, Charles Zerweck, Tim Houser, Anthony Andrasfay, Bob Gauthier, Charles Holland, Daniel Piacquadio
BACKGROUND: This study measured skin hydration and occlusivity of two test products [halobetasol propionate lotion, 0.05% (HBP Lotion) and Ultravate® (halobetasol propionate) cream, 0.05% (HBP Cream)] at 2, 4, and 6 hours after application to skin test sites previously challenged by dry shaving, which was performed to compromise the integrity of the stratum corneum barrier. METHODS: Trans-epidermal water loss (TEWL), an indicator of skin barrier function, was measured using cyberDERM, inc...
February 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28293528/intermediate-phenotype-between-adult-syndrome-and-eec-syndrome-caused-by-r243q-mutation-in-tp63
#5
Yuki Otsuki, Koichi Ueda, Chisei Satoh, Ryuta Maekawa, Koh-Ichiro Yoshiura, Sachiko Iseki
A patient who had ectrodactyly, dry skin, exfoliative dermatitis, and hypodontia with peg-shaped teeth, but not cleft lip and palate, is described. Ectrodactyly with a tooth anomaly is recognized in both acro-dermato-ungual-lacrimal-tooth (ADULT) syndrome and ectrodactyly-ectodermal dysplasia-cleft (EEC) syndrome. These 2 syndromes are caused by heterozygous mutations in the transcriptional factor gene p63. Mutation analysis of p63 gene showed a heterozygous mutation c.728G>A, p.Arg243Gln (previously referred to as R204Q) in the patient, but not in his parents...
December 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28292574/effect-of-lipid-based-dry-eye-supplements-on-the-tear-film-in-wearers-of-eye-cosmetics
#6
Michael T M Wang, Irene Sung Hee Cho, Soo Hee Jung, Jennifer P Craig
PURPOSE: To compare the effects on tear film parameters and contamination in cosmetic eyeliner wearers, after single application of two lipid-based dry eye treatments: a lipid-containing lubricant eye drop and a phospholipid liposomal spray. METHODS: Fifty participants were enrolled in a prospective, randomised, paired-eye, investigator-masked trial. Pencil eyeliner (Body Shop(®) Crayon Eye Definer) was applied to the upper eyelid periocular skin of both eyes, anterior to the lash line...
March 11, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28286315/formulation-of-hydrophobic-peptides-for-skin-delivery-via-coated-microneedles
#7
Xin Zhao, Sion A Coulman, Stephanie J Hanna, F Susan Wong, Colin M Dayan, James C Birchall
Microneedles (MNs) have been investigated as a minimally-invasive delivery technology for a range of active pharmaceutical ingredients (APIs). Various formulations and methods for coating the surface of MNs with therapeutics have been proposed and exemplified, predominantly for hydrophilic drugs and particulates. The development of effective MN delivery formulations for hydrophobic drugs is more challenging with dosing restrictions and the use of organic solvents impacting on both the bioactivity and the kinetics of drug release...
March 9, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28283891/the-potential-role-for-early-biomarker-testing-as-part-of-a-modern-multidisciplinary-approach-to-sj%C3%A3-gren-s-syndrome-diagnosis
#8
REVIEW
Kenneth A Beckman, Jodi Luchs, Mark S Milner, Julian L Ambrus
Sjögren's syndrome (SS) is a chronic and progressive multisystem autoimmune disease typically managed by rheumatologists. Diagnostic delays are common, due in large part to the non-specific and variable nature of SS symptoms and the slow progression of disease. The hallmark characteristics of SS are dry eye and dry mouth, but there are a broad range of other possible symptoms such as joint and muscle pain, skin rashes, chronic dry cough, vaginal dryness, extremity numbness or tingling, and disabling fatigue...
March 10, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28277954/physiological-responses-to-fasting-and-estivation-for-the-three-toed-amphiuma-amphiuma-tridactylum
#9
Matthew E Smith, Stephen M Secor
Species of Amphiuma enter a state of subterranean estivation with the drying of their aquatic habitat. Characteristic of amphibian fasting and estivation is an initial depression of metabolism and tissue mass and function with fasting, followed by a more pronounced adaptive decrease in metabolism and tissue function with estivation. We hypothesized that Amphiuma likewise experiences a two-stage set of responses to estivation. Therefore, we examined the physiological responses of the three-toed amphiuma (Amphiuma tridactylum) to fasting and estivation treatments...
March 2017: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/28275123/body-monitoring-with-photonic-textiles-a-reflective-heartbeat-sensor-based-on-polymer-optical-fibres
#10
Brit M Quandt, Fabian Braun, Damien Ferrario, René M Rossi, Anke Scheel-Sailer, Martin Wolf, Gian-Luca Bona, Rudolf Hufenus, Lukas J Scherer, Luciano F Boesel
Knowledge of an individual's skin condition is important for pressure ulcer prevention. Detecting early changes in skin through perfusion, oxygen saturation values, and pressure on tissue and subsequent therapeutic intervention could increase patients' quality of life drastically. However, most existing sensing options create additional risk of ulcer development due to further pressure on and chafing of the skin. Here, as a first component, we present a flexible, photonic textile-based sensor for the continuous monitoring of the heartbeat and blood flow...
March 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28269550/modular-multipin-electrodes-for-comfortable-dry-eeg
#11
P Fiedler, D Strohmeier, A Hunold, S Griebel, R Muhle, M Schreiber, P Pedrosa, B Vasconcelos, C Fonseca, F Vaz, J Haueisen
Electrode and cap concepts for continuous and ubiquitous monitoring of brain activity will open up new fields of application and contribute to increased use of electroencephalography (EEG) in clinical routine, neurosciences, brain-computer-interfacing and out-of-the-lab monitoring. However, mobile and unobtrusive applications are currently hindered by the lack of applicable convenient and reliable electrode and cap systems. We propose a novel modular electrode concept based on a flexible polymer substrate, coated with electrically conductive metallic films...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28269549/novel-dry-electrodes-for-recording-electrodermal-activity
#12
Hugo F Posada-Quintero, Ryan Rood, Yeonsik Noh, Ken Burnham, John Pennace, Ki H Chon
Novel carbon/salt adhesive (CSA) electrodes have been found suitable for collecting electrodermal activity (EDA) signals. Ag/AgCl electrodes are considered the standard for collecting EDA signals, because it highly avoids electrodes' polarization. Ag is an expensive commodity. Furthermore, a hydrogel layer is needed for the Ag/AgCl electrodes to collect EDA signals. Adding hydrogel to the electrodes is a cumbersome process. Aforementioned circumstances highlight the need for a more accessible media to collect these signals, allowing EDA use to spread...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28262158/psychosis-as-a-late-manifestation-of-sheehan-s-syndrome
#13
Mukku Shiva Shanker Reddy, Abhinav Nahar, Harish Thippeswamy, Chaturvedi Santosh Kumar
Sheehan's syndrome occurs as a result of ischemic pituitary necrosis due to severe postpartum haemorrhage. It is one of the most common causes of hypopituitarism in underdeveloped or developing countries. Characteristic manifestations include failure to lactate or to resume menses, genital and axillary hair loss, asthenia and weakness, fine wrinkles around the eyes and lips, signs of premature aging, dry skin, hypopigmentation and other evidence of hypopituitarism. Uncommonly it can present with psychosis. There are only few case reports of psychoses in patients with Sheehan's syndrome...
February 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/28252436/development-of-formulation-and-technology-for-the-poly-3-3-4-dihydroxyphenyl-glyceric-acid-gel
#14
S Gokadze, V Barbakadze, K Mulkijanyan, L Bakuridze, A Bakuridze
One of the most actual problems of pharmacy is the development of medication forms for external application with complex effects on (gel, emplastro, aerosol, etc.) skin wounds, burns and inflammatory factors. The centuries-old practice of using phyto-preparations (herbal remedies) proved that they have fewer side effects in comparison with synthetic drugs. Despite the wide application of herbal preparations, in the literature there is a little information about their application in development of wound and burn healing modern dosage forms...
January 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28251309/relationship-between-biochemical-factors-and-skin-symptoms-in-chronic-venous-disease
#15
Yasushi Takai, Keiichi Hiramoto, Yoshiyuki Nishimura, Kazuya Ooi
Chronic venous disease (CVD) is a common venous disease of the lower extremities and patients often develop symptoms of itching and skin roughness. An easy to use and objective skin examination was recently developed that allows measurement of the level of stratum corneum content and transepidermal water loss (TEWL), which can indicate the status of the barrier function of the stratum corneum. Previous studies demonstrated that histamine production from mast cells, and tryptase and matrix metalloprotease-9 levels were associated with skin inflammation...
March 1, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28250773/meretoja-s-syndrome-lattice-corneal-dystrophy-gelsolin-type
#16
I Casal, S Monteiro, C Abreu, M Neves, L Oliveira, M Beirão
Lattice corneal dystrophy gelsolin type was first described in 1969 by Jouko Meretoja, a Finnish ophthalmologist. It is caused by an autosomal dominant mutation in gelsolin gene resulting in unstable protein fragments and amyloid deposition in various organs. The age of onset is usually after the third decade of life and typical diagnostic triad includes progressive bilateral facial paralysis, loose skin, and lattice corneal dystrophy. We report a case of a 53-year-old female patient referred to our Department of Ophthalmology by severe dry eye and incomplete eyelid closure...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28249803/venomics-analyses-of-the-skin-secretion-of-dermatonotus-muelleri-preliminary-proteomic-and-metabolomic-profiling
#17
Ingrid Duarte Cavalcante, Marta Maria Antoniazzi, Carlos Jared, Osmindo R Pires, Juliana Mozer Sciani, Daniel Carvalho Pimenta
Dermatonotus muelleri is the sole species of the Dermatonotus genus and inhabits Argentina, Bolivia, Brazil and Paraguay. This animal exhibits an explosive reproductive behavior during the Southern spring months, which lasts only for five days. Moreover, this animal displays specific adaptations to the habitat resulting in the energy conservation needed during either the intense reproduction period or times of estivation. During dry seasons and/or food shortages D. muelleri can survive because its food specialization and ability to dig an underground chamber for protection...
February 27, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28249553/occupational-exposure-and-respiratory-health-problems-among-nutmeg-production-workers-in-grenada-the-caribbean
#18
Muge Akpinar-Elci, Satesh Bidaisee, MyNgoc Thuy Nguyen, Omur Cinar Elci
BACKGROUND: The nutmeg industry is a major contributor to the Grenadian economy. However, workers in the industry face many environmental and occupational health risks. OBJECTIVES: The goal of this study was to investigate respiratory health problems and possible related occupational exposures among nutmeg production workers. METHODS: A questionnaire, spirometry and allergen skin-prick test was given to 92 nutmeg workers. Samples for measurement of airborne dust, mold, and phosphine were also collected from work environments...
March 2, 2017: International Journal of Occupational and Environmental Health
https://www.readbyqxmd.com/read/28249031/a-de-novo-variant-in-the-asprv1-gene-in-a-dog-with-ichthyosis
#19
Anina Bauer, Dominik P Waluk, Arnaud Galichet, Katrin Timm, Vidhya Jagannathan, Beyza S Sayar, Dominique J Wiener, Elisabeth Dietschi, Eliane J Müller, Petra Roosje, Monika M Welle, Tosso Leeb
Ichthyoses are a heterogeneous group of inherited cornification disorders characterized by generalized dry skin, scaling and/or hyperkeratosis. Ichthyosis vulgaris is the most common form of ichthyosis in humans and caused by genetic variants in the FLG gene encoding filaggrin. Filaggrin is a key player in the formation of the stratum corneum, the uppermost layer of the epidermis and therefore crucial for barrier function. During terminal differentiation of keratinocytes, the precursor profilaggrin is cleaved by several proteases into filaggrin monomers and eventually processed into free amino acids contributing to the hydration of the cornified layer...
March 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28243135/repeated-short-climatic-change-affects-the-epidermal-differentiation-program-and-leads-to-matrix-remodeling-in-a-human-organotypic-skin-model
#20
Laetitia-Barbollat Boutrand, Amélie Thépot, Charlotte Muther, Aurélie Boher, Julie Robic, Christelle Guéré, Katell Vié, Odile Damour, Jérôme Lamartine
Human skin is subject to frequent changes in ambient temperature and humidity and needs to cope with these environmental modifications. To decipher the molecular response of human skin to repeated climatic change, a versatile model of skin equivalent subject to "hot-wet" (40°C, 80% relative humidity [RH]) or "cold-dry" (10°C, 40% RH) climatic stress repeated daily was used. To obtain an exhaustive view of the molecular mechanisms elicited by climatic change, large-scale gene expression DNA microarray analysis was performed and modulated function was determined by bioinformatic annotation...
2017: Clinical, Cosmetic and Investigational Dermatology
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