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https://www.readbyqxmd.com/read/28938693/the-regulation-of-immune-cells-by-lactobacilli-a-potential-therapeutic-target-for-anti-atherosclerosis-therapy
#1
REVIEW
Ya-Hui Ding, Lin-Yan Qian, Jie Pang, Jing-Yang Lin, Qiang Xu, Li-Hong Wang, Dong-Sheng Huang, Hai Zou
Atherosclerosis is an inflammatory disease regulated by several immune cells including lymphocytes, macrophages and dendritic cells. Gut probiotic bacteria like Lactobacilli have been shown immunomodificatory effects in the progression of atherogenesis. Some Lactobacillus stains can upregulate the activity of regulatory T-lymphocytes, suppress T-lymphocyte helper (Th) cells Th1, Th17, alter the Th1/Th2 ratio, influence the subsets ratio of M1/M2 macrophages, inhibit foam cell formation by suppressing macrophage phagocytosis of oxidized low-density lipoprotein, block the activation of the immune system with dendritic cells, which are expected to suppress the atherosclerosis-related inflammation...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28937897/the-role-of-genetic-factors-in-the-outbreak-mechanism-of-dental-caries
#2
Junko Shimomura-Kuroki, Tomoko Nashida, Yukio Miyagawa, Tsuneo Sekimoto
OBJECTIVE: The aim of the present study was to investigate the relationships between cariogenic bacterial infection and single nucleotide polymorphisms (SNPs) in candidate genes associated with dental caries, and to explore the factors related to caries in children. STUDY DESIGN: Children aged 3 to 11 years were selected. Detection of cariogenic bacteria (Streptococcus mutans, Streptococcus oralis, Streptococcus sobrinus and Lactobacillus) from the plaque of each patient, and SNP analyses of five candidate genes (MBL2, TAS2R38, GLUT2, MMP13 and CA6) were performed using DNA isolated from buccal mucosal cells...
September 22, 2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28936946/genetic-tools-for-the-enhancement-of-probiotic-properties
#3
Laura Ortiz-Velez, Robert Britton
The Lactobacillus genus is a diverse group of microorganisms, many of which are of industrial and medical relevance. Several Lactobacillus species have been used as probiotics, organisms that when present in sufficient quantities confer a health benefit to the host. A significant limitation to the mechanistic understanding of how these microbes provide health benefits to their hosts and how they can be used as therapeutic delivery systems has been the lack of genetic strategies to efficiently manipulate their genomes...
September 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28936766/use-of-lactobacilli-in-cereal-legume-fermentation-and-as-potential-probiotics-towards-phytate-hydrolysis
#4
Girish K Amritha, G Venkateswaran
Phytate is a potent inhibitor of mineral absorption in humans occurring in plant-based food. Application of lactobacilli that produce phytate-degrading enzymes (phytases) to reduce phytate is an interesting yet a not much explored sector of research. Therefore, phytate dephosphorylation by Lactobacillus plantarum MTCC 1325 was evaluated. Cells at stationary phase showed phytase activity which was maximal at 24 h of growth. Glucose concentration and the type of phosphorous source in the media modulated the enzyme activity...
September 21, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28935987/toward-the-identification-of-a-type-i-toxin-antitoxin-system-in-the-plasmid-dna-of-dairy-lactobacillus-rhamnosus
#5
Claudia Folli, Alessia Levante, Riccardo Percudani, Davide Amidani, Stefania Bottazzi, Alberto Ferrari, Claudio Rivetti, Erasmo Neviani, Camilla Lazzi
Plasmids carry genes that give bacteria beneficial traits and allow them to survive in competitive environments. In many cases, they also harbor toxin-antitoxin (TA) systems necessary for plasmid maintenance. TA systems are generally characterized by a stable "toxin", a protein or peptide capable of killing the cell upon plasmid loss and by an unstable "antitoxin", a protein or a non-coding RNA that inhibits toxin activity. Here we report data toward the identification of a RNA-regulated TA system in the plasmid DNA of L...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28935921/probiotic-reduces-bacterial-translocation-in-type-2-diabetes-mellitus-a-randomised-controlled-study
#6
Junko Sato, Akio Kanazawa, Kosuke Azuma, Fuki Ikeda, Hiromasa Goto, Koji Komiya, Rei Kanno, Yoshifumi Tamura, Takashi Asahara, Takuya Takahashi, Koji Nomoto, Yuichiro Yamashiro, Hirotaka Watada
Gut bacterial translocation to the blood may play an important role in the development of insulin resistance in type 2 diabetes. Here, we performed an interventional randomised control study to investigate whether probiotics could reduce bacterial translocation and cause changes in the gut microbiota. Seventy Japanese patients with type 2 diabetes were randomised to two groups: the probiotic group drank Lactobacillus casei strain Shirota-fermented milk, while the control group ingested no probiotics. The trial was conducted for 16 weeks...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28935727/complete-genome-sequences-of-lactobacillus-curvatus-kg6-l-curvatus-mrs6-and-lactobacillus-sakei-fam18311-isolated-from-fermented-meat-products
#7
Christoph Jans, Sandra Lagler, Christophe Lacroix, Leo Meile, Marc J A Stevens
The genomes of Lactobacillus curvatus KG6, L. curvatus MRS6, and Lactobacillus sakei FAM18311 were sequenced and assembled using PacBio single-molecule real-time (SMRT) technology. The strains were isolated from Swiss fermented meat products. Circular chromosomes were of 1.98 Mbp (KG6), 2.11 Mbp (MRS6), and 1.95 Mbp (FAM18311), with a G+C content of 41.3 to 42.0%.
September 21, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28935567/lactobacillus-fermentum-ftdc-8312-combats-hypercholesterolemia-via-alteration-of-gut-microbiota
#8
Huey-Shi Lye, Tamotsu Kato, Wai-Yee Low, Todd D Taylor, Tulika Prakash, Lee-Ching Lew, Hiroshi Ohno, Min-Tze Liong
In this study, hypercholesterolemic mice fed with Lactobacillus fermentum FTDC 8312 after a seven-week feeding trial showed a reduction in serum total cholesterol (TC) levels, accompanied by a decrease in serum low-density lipoprotein cholesterol (LDL-C) levels, an increase in serum high-density lipoprotein cholesterol (HDL-C) levels, and a decreased ratio of apoB100:apoA1 when compared to those fed with control or a type strain, L. fermentum JCM 1173. These have contributed to a decrease in atherogenic indices (TC/HDL-C) of mice on the FTDC 8312 diet...
September 18, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28935539/molecular-structure-of-cyclomaltodextrinase-derived-from-amylolytic-lactic-acid-bacterium-enterococcus-faecium-k-1-and-properties-of-recombinant-enzymes-expressed-in-escherichia-coli-and-lactobacillus-plantarum
#9
Kridsada Unban, Apinun Kanpiengjai, Saisamorn Lumyong, Thu-Ha Nguyen, Dietmar Haltrich, Chartchai Khanongnuch
Gene encoding cyclomaltodextrinase (Cdx) from amylolytic lactic acid bacterium Enterococcus faecium K-1 was cloned and nucleotide sequence was analyzed. The open-reading frame consisted of 1767bp encoding 588 deduced amino acids. Consequently, four typically conserved regions of the glycoside hydrolase family 13 were revealed; however, nine exceeding amino acids (DSYQMTDVP) were found at the 282-290 position in comparison to previously reported cyclomaltodextrinases. This difference is believed to have an influence on the substrate specificity of this enzyme...
September 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28935288/the-potential-role-of-gut-microbiota-in-pancreatic-disease-a-systematic-review
#10
REVIEW
Robert Memba, Sinead N Duggan, Hazel M Ni Chonchubhair, Oonagh M Griffin, Yasir Bashir, Donal B O'Connor, Anne Murphy, Jean McMahon, Yuri Volcov, Barbara M Ryan, Kevin C Conlon
BACKGROUND: Several studies have suggested a link between microbiota imbalance and some gastrointestinal, inflammatory and neoplastic diseases. However, the role in pancreatic diseases remain unclear. To evaluate the available evidence for pancreatic diseases, we undertook a systematic review. METHODS: OVID Medline (1946-2017), EMBASE (1980-2017) and the Cochrane Central Register of Controlled Trials (CENTRAL Issue 3, 2017) were searched for studies on microbiota in pancreatic disease...
September 6, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28934437/group-b-streptococcus-and-the-vaginal-microbiota
#11
Geoffrey H Rosen, Tara M Randis, Purnahamsi V Desai, Katherine J Sapra, Bing Ma, Pawel Gajer, Michael S Humphrys, Jacques Ravel, Shari E Gelber, Adam J Ratner
Background: Streptococcus agalactiae (group B Streptococcus [GBS]) is an important neonatal pathogen and emerging cause of disease in adults. The major risk factor for neonatal disease is maternal vaginal colonization. However, little is known about the relationship between GBS and vaginal microbiota. Methods: Vaginal lavage samples from nonpregnant women were tested for GBS, and amplicon-based sequencing targeting the 16S ribosomal RNA V3-V4 region was performed...
September 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28934382/complete-genome-analysis-of-lactobacillus-fermentum-sk152-from-kimchi-reveals-genes-associated-with-its-antimicrobial-activity
#12
DongAhn Yoo, Bernadette B Bagon, Valerie Diane V Valeriano, Ju Kyoung Oh, Heebal Kim, Seoae Cho, Dae-Kyung Kang
Research findings on probiotics highlight their importance in repressing harmful bacteria, leading to more extensive research on their potential applications. We analysed the genome of Lactobacillus fermentum SK152, which was isolated from the Korean traditional fermented vegetable dish kimchi, to determine the genetic makeup and genetic factors responsible for the antimicrobial activity of L. fermentum SK152 and performed a comparative genome analysis with other L. fermentum strains. The genome of L. fermentum SK152 was found to comprise a complete circular chromosome of 2092 273 bp, with an estimated GC content of 51...
October 2, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28934296/lactobacillus-paracasei-gmnl-32-exerts-a-therapeutic-effect-on-cardiac-abnormalities-in-nzb-w-f1-mice
#13
Wei-Syun Hu, Peramaiyan Rajendran, Bor-Show Tzang, Yu-Lan Yeh, Chia-Yao Shen, Ray-Jade Chen, Tsung-Jung Ho, Viswanadha Vijaya Padma, Yi-Hsing Chen, Chih-Yang Huang
Systemic lupus erythematosus (SLE) is a disease that mostly affects women. Accelerated atherosclerosis is a high-risk factor associated with SLE patients. SLE associated with cardiovascular disease is one of the most important causes of death. In this study, we demonstrated that Lactobacillus paracasei GMNL-32 (GMNL-32), a probiotic species, exhibits anti-fibrosis and anti-apoptotic effects on the cardiac tissue of NZB/WF1 mice. Female NZB/W F1 mice, a well-known and commonly used lupus-prone mouse strain, were treated with or without GMNL-32 administration for 12 weeks...
2017: PloS One
https://www.readbyqxmd.com/read/28934262/effects-of-eimeria-tenella-infection-on-chicken-caecal-microbiome-diversity-exploring-variation-associated-with-severity-of-pathology
#14
Sarah E Macdonald, Matthew J Nolan, Kimberley Harman, Kay Boulton, David A Hume, Fiona M Tomley, Richard A Stabler, Damer P Blake
Eimeria species cause the intestinal disease coccidiosis, most notably in poultry. While the direct impact of coccidiosis on animal health and welfare is clear, its influence on the enteric microbiota and by-stander effects on chicken health and production remains largely unknown, with the possible exception of Clostridium perfringens (necrotic enteritis). This study evaluated the composition and structure of the caecal microbiome in the presence or absence of a defined Eimeria tenella challenge infection in Cobb500 broiler chickens using 16S rRNA amplicon sequencing...
2017: PloS One
https://www.readbyqxmd.com/read/28933759/lactic-acid-bacteria-and-their-bacteriocins-classification-biosynthesis-and-applications-against-uropathogens-a-mini-review
#15
REVIEW
Mduduzi Paul Mokoena
Several lactic acid bacteria (LAB) isolates from the Lactobacillus genera have been applied in food preservation, partly due to their antimicrobial properties. Their application in the control of human pathogens holds promise provided appropriate strains are scientifically chosen and a suitable mode of delivery is utilized. Urinary tract infection (UTI) is a global problem, affecting mainly diabetic patients and women. Many uropathogens are developing resistance to commonly used antibiotics. There is a need for more research on the ability of LAB to inhibit uropathogens, with a view to apply them in clinical settings, while adhering to strict selection guidelines in the choice of candidate LAB...
July 26, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28932814/the-gut-commensal-microbiome-of-drosophila-melanogaster-is-modified-by-the-endosymbiont-wolbachia
#16
Rama K Simhadri, Eva M Fast, Rong Guo, Michaela J Schultz, Natalie Vaisman, Luis Ortiz, Joanna Bybee, Barton E Slatko, Horacio M Frydman
Endosymbiotic Wolbachia bacteria and the gut microbiome have independently been shown to affect several aspects of insect biology, including reproduction, development, life span, stem cell activity, and resistance to human pathogens, in insect vectors. This work shows that Wolbachia bacteria, which reside mainly in the fly germline, affect the microbial species present in the fly gut in a lab-reared strain. Drosophila melanogaster hosts two main genera of commensal bacteria-Acetobacter and Lactobacillus. Wolbachia-infected flies have significantly reduced titers of Acetobacter...
September 2017: MSphere
https://www.readbyqxmd.com/read/28932705/probiotics-for-the-treatment-of-atopic-dermatitis-in-children-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#17
Ruixue Huang, Huacheng Ning, Minxue Shen, Jie Li, Jianglin Zhang, Xiang Chen
Objective: Atopic dermatitis (AD) is a prevalent, burdensome, and psychologically important pediatric concern. Probiotics have been suggested as a treatment for AD. Some reports have explored this topic; however, the utility of probiotics for AD remains to be firmly established. Methods: To assess the effects of probiotics on AD in children, the PubMed/Medline, Cochrane Library Scopus, and OVID databases were searched for reports published in the English language. Results: Thirteen studies were identified. Significantly higher SCORAD values favoring probiotics over controls were observed (mean difference [MD], -3...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28932367/double-strain-probiotic-effect-on-helicobacter-pylori-infection-treatment-a-double-blinded-randomized-controlled-trial
#18
Mehdi Haghdoost, Sepehr Taghizadeh, Majid Montazer, Parinaz Poorshahverdi, Ali Ramouz, Sanam Fakour
BACKGROUND: A decreased rate of successful helicobacter pylori (H.pylori) infection treatment has revealed serious demand for more effective regimens to eradicate infection. Therefore, probiotics have recently been considered to increase the rate of antibiotic regimens efficacy in H. pylori infections. In current randomized controlled trial, we evaluated the effect of double strain probiotic combination with standard triple therapy (STT), in the eradication rate of H. pylori infection...
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/28932278/assessment-of-antibiotic-susceptibility-in-lactobacillus-isolates-from-chickens
#19
Marta Dec, Renata Urban-Chmiel, Dagmara Stępień-Pyśniak, Andrzej Wernicki
BACKGROUND: The aim of this study was to determine the susceptibility of 88 Lactobacillus isolates derived from chickens to antibiotic substances and to detect drug-resistance genes. RESULTS: The minimal inhibitory concentration of 13 antimicrobial substances was determined by the broth microdilution method, and resistance genes were detected by PCR. We recorded a high prevalence of resistance to tiamulin (90% resistant isolates), tetracyclines (74%) and lincomycin (70%), and a moderately high frequency of resistance to enrofloxacin (48%), macrolides (42%), aminoglycosides (12...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/28931859/a-longitudinal-analysis-of-the-vaginal-microbiota-and-vaginal-immune-mediators-in-women-from-sub-saharan-africa
#20
Vicky Jespers, Jordan Kyongo, Sarah Joseph, Liselotte Hardy, Piet Cools, Tania Crucitti, Mary Mwaura, Gilles Ndayisaba, Sinead Delany-Moretlwe, Jozefien Buyze, Guido Vanham, Janneke H H M van de Wijgert
In cross-sectional studies increased vaginal bacterial diversity has been associated with vaginal inflammation which can be detrimental for health. We describe longitudinal changes at 5 visits over 8 weeks in vaginal microbiota and immune mediators in African women. Women (N = 40) with a normal Nugent score at all visits had a stable lactobacilli dominated microbiota with prevailing Lactobacillus iners. Presence of prostate-specific antigen (proxy for recent sex) and being amenorrhoeic (due to progestin-injectable use), but not recent vaginal cleansing, were significantly associated with microbiota diversity and inflammation (controlled for menstrual cycle and other confounders)...
September 20, 2017: Scientific Reports
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