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https://www.readbyqxmd.com/read/28646502/the-liver-gut-microbiota-axis-modulates-hepatotoxicity-of-tacrine-in-the-rat
#1
Lian Yee Yip, Chiu Cheong Aw, Sze Han Lee, Yi Shuen Hong, Han Chen Ku, Winston Hecheng Xu, Jessalyn Mei Xuan Chan, Eleanor Jing Yi Cheong, Kern Rei Chng, Amanda Hui Qi Ng, Niranjan Nagarajan, Ratha Mahendran, Yuan Kun Lee, Edward R Browne, Eric Chun Yong Chan
The gut microbiota possesses diverse metabolic activities but its contribution towards heterogeneous toxicological responses is poorly understood. Here, we elucidate the role of the liver-gut microbiota axis in underpinning the hepatotoxicity of tacrine. We employed an integrated strategy combining pharmacokinetics, toxicology, metabonomics, genomics and metagenomics to elucidate and validate the mechanism of tacrine-induced hepatotoxicity in Lister hooded rats. Pharmacokinetic studies in rats demonstrated 3...
June 23, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28643906/in-vitro-evaluation-of-surface-properties-of-pro-seal-%C3%A2-and-opal-%C3%A2-seal-tm-in-preventing-white-spot-lesions
#2
T S Premaraj, N Rohani, D Covey, S Premaraj
OBJECTIVES: To evaluate the surface properties of two commercially available sealants (Pro Seal(®) (PS) and Opal(®) Seal(TM) (OS)) in terms of fluoride(F) release, biofilm formation of Streptococcus mutans and Lactobacillus and the ability to resist acid penetration. SETTING: University of Nebraska Medical Center. MATERIAL & METHODS: Discs of similar diameter and thickness were made from OS and PS. Discs were soaked in double-distilled water, and F released was measured with fluoride meter daily for 14 consecutive days, then at 21 and 28 days...
June 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28643742/in-vitro-activity-of-probiotic-lactobacillus-reuteri-against-gastric-cancer-progression-by-downregulation-of-urokinase-plasminogen-activator-urokinase-plasminogen-activator-receptor-gene-expression
#3
Bahareh Sadat Rasouli, Ali Ghadimi-Darsajini, Reza Nekouian, Gholam-Reza Iragian
BACKGROUND: Gastric cancer (GC) is the third leading cause of cancer death, and most patients represent metastatic phenotype at the time of diagnosis. Urokinase plasminogen activator (uPA) system is well known for its critical roles in cancer cells invasion since uPA/uPA receptor (uPAR) overexpresses in several cancers. Subsequently, suppression of uPA/uPAR gene expression improves patients overall survival and prevents cancer progression. OBJECTIVES: The aim of the current study was to investigate possible effects of live Lactobacillus reuteri as a probiotic in inhibition of GC cells proliferation and invasion...
April 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28643623/the-genomic-basis-of-lactobacilli-as-health-promoting-organisms
#4
Elisa Salvetti, Paul W O'Toole
Lactobacilli occupy a unique position in human culture and scientific history. Like brewer's and baker's yeast, lactobacilli have been associated with food production and preservation for thousands of years. Lactobacillus species are used in mixed microbial cultures, such as the classical Lactobacillus bulgaricus/Streptococcus thermophilus inoculum for yogurt fermentation, or combinations of diverse lactobacilli/yeasts in kefir grains. The association of lactobacilli consumption with greater longevity and improved health formed the basis for developing lactobacilli as probiotics, whose market has exploded worldwide in the past 10 years...
June 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28643226/capsular-polysaccharides-of-lactobacillus-spp-theoretical-and-practical-aspects-of-simple-visualization-methods
#5
Magdalena Oleksy, Elżbieta Klewicka
Lactobacillus strains can synthesize capsular polysaccharides (CPS), which are important substances in the dairy industry-they exhibit many important technological as well as health-promoting properties. Technological advancements have made it possible to detect bacterial capsules using costly and labor-intensive methods, such as serological reactions, molecular genetic techniques, and electron microscopy. Light microscopy, which is the method of interest in this paper, is one of the most widely accessible and cheapest techniques...
June 22, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28642703/different-regulation-of-interleukin-1-production-and-activity-in-monocytes-and-macrophages-innate-memory-as-an-endogenous-mechanism-of-il-1-inhibition
#6
Mariusz P Madej, Elfi Töpfer, Diana Boraschi, Paola Italiani
Production and activity of interleukin (IL)-1β are kept under strict control in our body, because of its powerful inflammation-promoting capacity. Control of IL-1β production and activity allows IL-1 to exert its defensive activities without causing extensive tissue damage. Monocytes are the major producers of IL-1β during inflammation, but they are also able to produce significant amounts of IL-1 inhibitors such as IL-1Ra and the soluble form of the decoy receptor IL-1R2, in an auto-regulatory feedback loop...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28640154/vaginal-microbiota-and-genitourinary-menopausal-symptoms-a-cross-sectional-analysis
#7
Caroline M Mitchell, Sujatha Srinivasan, Xiang Zhan, Michael C Wu, Susan D Reed, Katherine A Guthrie, Andrea Z LaCroix, Tina Fiedler, Matthew Munch, Congzhou Liu, Noah G Hoffman, Ian A Blair, Katherine Newton, Ellen W Freeman, Hadine Joffe, Lee Cohen, David N Fredricks
OBJECTIVE: To examine associations between the composition of the vaginal microbiota and genitourinary menopausal symptoms, serum estrogen, and vaginal glycogen. METHODS: For this cross-sectional study, 88 women aged 40 to 62 years, enrolled in a hot flash treatment trial, provided vaginal swabs and a blood sample at enrollment. Bacterial communities were characterized using 16S rRNA PCR and deep sequencing targeting the V3-V4 region. Quantities of Lactobacillus crispatus and Lactobacillus iners were measured using qPCR...
June 19, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28639907/ferrichrome-identified-from-lactobacillus-casei-atcc334-induces-apoptosis-through-its-iron-binding-site-in-gastric-cancer-cells
#8
Masami Ijiri, Mikihiro Fujiya, Hiroaki Konishi, Hiroki Tanaka, Nobuhiro Ueno, Shin Kashima, Kentaro Moriichi, Junpei Sasajima, Katsuya Ikuta, Toshikatsu Okumura
Ferrichrome is known to be a siderophore, but it was recently identified as a tumor-suppressive molecule derived from Lactobacillus casei ATCC334 ( L. casei). In the present study, we investigated the effects of ferrichrome in gastric cancer cells. Cell lines and xenograft models treated with ferrichrome demonstrated growth suppression. The expression levels of cleaved poly (adenosine diphosphate-ribose) polymerase, and cleaved caspase-9 were increased by ferrichrome treatment. Although the tumor-suppressive effects of ferrichrome were almost completely diminished by the iron chelation, the reduction in the intracellular iron by ferrichrome did not correlate with its tumor-suppressive effects...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28638850/probiotic-lactobacillus-species-strengthen-intestinal-barrier-function-and-tight-junction-integrity-in-experimental-necrotizing-enterocolitis
#9
Brian P Blackwood, Carrie Y Yuan, Douglas R Wood, Joseph D Nicolas, Justyna S Grothaus, Catherine J Hunter
Necrotizing enterocolitis (NEC) is a serious intestinal disease that occurs in newborn infants. It is associated with major morbidity and affects 5% of all infants admitted to neonatal intensive care units. Probiotics have variable efficacy in preventing necrotizing enterocolitis. Tight junctions (TJ) are protein complexes that maintain epithelial barrier integrity. We hypothesized that the probiotics Lactobacillus rhamnosus and Lactobacillus plantarum strengthen intestinal barrier function, promote TJ integrity, and protect against experimental NEC...
April 2017: J Probiotics Health
https://www.readbyqxmd.com/read/28637485/the-development-of-lower-respiratory-tract-microbiome-in-mice
#10
Nisha Singh, Asheema Vats, Aditi Sharma, Amit Arora, Ashwani Kumar
BACKGROUND: Although culture-independent methods have paved the way for characterization of the lung microbiome, the dynamic changes in the lung microbiome from neonatal stage to adult age have not been investigated. RESULTS: In this study, we tracked changes in composition and diversity of the lung microbiome in C57BL/6N mice, starting from 1-week-old neonates to 8-week-old mice. Towards this, the lungs were sterilely excised from mice of different ages from 1 to 8 weeks...
June 21, 2017: Microbiome
https://www.readbyqxmd.com/read/28637158/a-reused-method-for-molasses-processed-wastewater-effect-on-silage-quality-and-anaerobic-digestion-performance-of-pennisetum-purpereum
#11
Lianhua Li, Zhenhong Yuan, Yongming Sun, Xiaoying Kong, Pengyu Dong, Jia Zhang
The silage quality and anaerobic digestion performance of Pennisetum purpereum with molasses-processed wastewater addition were assessed. The silage samples with molasses-processed wastewater addition obtained higher lactic acid concentration of 15.18-23.38mg/g FM, lower pH value of 3.96-4.45 and lower NH3-N content of 0.47-0.64mg/g FM. No obvious difference was observed in the dominant phyla and genus, but the relative abundance of Lactobacillus reached up to 77.39%, increased by 84% compared to the silage samples without molasses-processed wastewater addition...
May 4, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28636459/inhibition-of-fusarium-solani-infection-in-murine-keratocytes-by-lactobacillus-salivarius-ssp-salivarius-jcm1231-culture-filtrate-in-vitro
#12
Jianzhang Hu, Fang Chen, Tong Kan, Hua Zhuang, Jingjin Zhang, Xiaoli Han
PURPOSE: To explore the inhibitory activity of Lactobacillus salivarius ssp. salivarius JCM1231 (L. salivarius JCM1231) culture filtrate against Fusarium solani (F. solani) and its effects on murine keratocytes (MKs) infected with F. solani. METHODS: L. salivarius JCM1231 was cultured in an anaerobic incubator for 24 h, and the L. salivarius culture filtrate (LSCF) was prepared .The antifungal activity of L. salivarius JCM1231 against F. solani was determined with a plate overlay assay, agar diffusion assay, and conidial germination inhibition test...
June 21, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28636003/in-vitro-modulation-of-gut-microbiota-by-whey-protein-to-preserve-intestinal-health
#13
T Sánchez-Moya, R López-Nicolás, D Planes, C A González-Bermúdez, G Ros-Berruezo, C Frontela-Saseta
The effect of several types of whey milk - cow, sheep, goat and a mixture of them (60 : 20 : 20, respectively) - was assessed in the human gut microbiota. The prebiotic potential of these substrates was evaluated through in vitro gastrointestinal digestion following faecal batch culture fermentations (mimicking colonic fermentation) for 48 hours, using faeces from normal-weight (NW) and obese (OB) donors. Throughout the fermentation process, pH, gas production, short chain and branched fatty acids (SCFA-BCFA) were measured, as well as the changes of microbiota using qPCR...
June 21, 2017: Food & Function
https://www.readbyqxmd.com/read/28634850/novel-vitamin-b12-producing-enterococcus-spp-and-preliminary-in-vitro-evaluation-of-probiotic-potentials
#14
Ping Li, Qing Gu, Yuejiao Wang, Yue Yu, Lanlan Yang, Jieyan V Chen
Vitamin B12 is an essential nutrient required for crucial metabolic processes in humans. Vitamin B12-producing lactic acid bacteria (LAB) have been attracting increased attentions currently because of the generally recognized as safe (GRAS) status. Most of recent studies focused on Lactobacillus, and little is known about B12-producing Enterococcus. In the present study, five Enterococcus strains isolated from infant feces were identified as vitamin B12 producers. Among them, Enterococcus faecium LZ86 had the highest B12 production (499...
June 20, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28634691/modulation-of-rotavirus-severe-gastroenteritis-by-the-combination-of-probiotics-and-prebiotics
#15
REVIEW
Guadalupe Gonzalez-Ochoa, Lilian K Flores-Mendoza, Ramona Icedo-Garcia, Ricardo Gomez-Flores, Patricia Tamez-Guerra
Annual mortality rates due to infectious diarrhea are about 2.2 million; children are the most vulnerable age group to severe gastroenteritis, representing group A rotaviruses as the main cause of disease. One of the main factors of rotavirus pathogenesis is the NSP4 protein, which has been characterized as a viral toxin involved in triggering several cellular responses leading to diarrhea. Furthermore, the rotavirus protein NSP1 has been associated with interferon production inhibition by inducing the degradation of interferon regulatory factors IRF3, IRF5, and IRF7...
June 20, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28634689/survival-intestinal-mucosa-adhesion-and-immunomodulatory-potential-of-lactobacillus-plantarum-strains
#16
Valentini Santarmaki, Yiannis Kourkoutas, Georgia Zoumpopoulou, Eleni Mavrogonatou, Mikis Kiourtzidis, Nikos Chorianopoulos, Chrysoula Tassou, Effie Tsakalidou, Constantinos Simopoulos, Petros Ypsilantis
Survival during transit through the gastrointestinal track, intestinal mucosa adhesion, and a potential immunomodulatory effect of Lactobacillus plantarum strains 2035 and ACA-DC 2640 were investigated in a rat model. According to microbiological and multiplex PCR analysis, both strains were detected in feces 24 h after either single-dose or daily administration for 7 days. Intestinal mucosa adhesion of L. plantarum 2035 was noted in the large intestine at 24 h after single-dose administration, while it was not detected at 48 h...
June 21, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28634492/effectiveness-of-different-preventive-programs-in-cariogram-parameters-of-young-adults-at-high-caries-risk
#17
Said Karabekiroğlu, Nimet Ünlü
OBJECTIVE: To evaluate the effectiveness of different preventive programs in young adults at high caries risk using Cariogram software. METHODS: Sixty-six young adults with high caries risk were evaluated. Dental caries risk for all subjects was determined according to WHO criteria. Subjects were divided into three different preventive groups (control: OH, fluoride varnish: FV, and chlorhexidine varnish: CV). They were followed for 12 weeks (baseline: T0, 1 week: T1, 4 weeks: T2, and 12 weeks: T3)...
2017: International Journal of Dentistry
https://www.readbyqxmd.com/read/28634130/the-inhibitory-impacts-of-lactobacillus-rhamnosus-gg-derived-extracellular-vesicles-on-the-growth-of-hepatic-cancer-cells
#18
Elham Behzadi, Hamideh Mahmoodzadeh Hosseini, Abbas Ali Imani Fooladi
Bacterial extracellular vesicles (EVs) have come forth into notice as possible important agent to mediate host-pathogen interactions. In this scientific research, the authors have tried to find out the effect of EVs derived from Lactobacillus rhamnosus GG (LDEVs) on the apoptosis induction in HepG2 cell line. The EVs were purified from the conditioned medium of Lactobacillus rhamnosus GG using ultrafiltration and confirmed by transmission electron microscopy (TEM). The HepG2 cells were treated with different concentrations of purified LDEVs and the cytotoxicity and their effects on the expression of bcl-2 and bax genes were assessed by the MTT assay and semi-quantitative RT-PCR, respectively...
June 17, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28633981/development-of-a-propidium-monoazide-polymerase-chain-reaction-assay-for-detection-of-viable-lactobacillus-brevis-in-beer
#19
Yanlin Ma, Yang Deng, Zhenbo Xu, Junyan Liu, Jianjun Dong, Hua Yin, Junhong Yu, Zongming Chang, Dongfeng Wang
The spoilage of beer by bacteria is of great concern to the brewer as this can lead to turbidity and abnormal flavors. The polymerase chain reaction (PCR) method for detection of beer-spoilage bacteria is highly specific and provides results much faster than traditional microbiology techniques. However, one of the drawbacks is the inability to differentiate between live and dead cells. In this paper, the combination of propidium monoazide (PMA) pretreatment and conventional PCR had been described. The established PMA-PCR identified beer spoilage Lactobacillus brevis based not on their identity, but on the presence of horA gene which we show to be highly correlated with the ability of beer spoilage LAB to grow in beer...
June 3, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/28632956/anti-inflammatory-potential-of-a-heat-killed-lactobacillus-strain-isolated-from-kimchi-on-house-dust-mite-induced-atopic-dermatitis-in-nc-nga-mice
#20
C Y Choi, Y H Kim, S Oh, H J Lee, J H Kim, S H Park, H J Kim, S J Lee, T Chun
AIMS: Atopic dermatitis (AD) is an allergic skin disease driven by the Th2-prone immune response. Therefore, a fundamental approach to restoring the Th1/Th2 balance is needed to treat AD. METHODS AND RESULTS: Eighteen different Lactobacillus strains isolated from Kimchi were screened to identify those that stimulated immune cells to secret Th1-type or Th2-type cytokines. Lactobacillus brevis NS1401 induced the greatest IFN-γ and IL-12 secretion and the least IL-4 production among the tested Lactobacillus strains...
June 20, 2017: Journal of Applied Microbiology
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