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https://www.readbyqxmd.com/read/29679952/injuries-to-cyclists-due-to-a-dog-bicycle-interaction
#1
Randall T Loder, Alan P Yaacoub
BACKGROUND:  Both dogs and bicycles are common in our society and thus a dog-bicycle interaction resulting in an injury to a cyclist is possible. It was the purpose of this study to investigate such injuries. METHODS:  The National Electronic Injury Surveillance System (NEISS) data for the 10-year period from 2006 through 2015 associated with bicycles were accessed. Injuries involving dogs were identified and the mechanism of injury determined. Due to the stratified and weighted nature of the NEISS data, statistical analyses were performed with SUDAAN 10 software (RTI International, Research Triangle Park, North Carolina, United States)...
April 21, 2018: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/29679936/controversies-in-monitoring-metastatic-breast-cancer-during-systemic-treatment-results-of-a-gim-gruppo-italiano-mammella-survey
#2
Bonotto Marta, Basile Debora, Gerratana Lorenzo, Pelizzari Giacomo, Bartoletti Michele, Vitale Maria Grazia, Fanotto Valentina, Lisanti Camilla, Mansutti Mauro, Minisini Alessandro Marco, Aprile Giuseppe, De Laurentiis Michele, Montemurro Filippo, Del Mastro Lucia, Puglisi Fabio
BACKGROUND: The optimal strategy for monitoring metastatic breast cancer (M-MBC) is unclear. Nevertheless, M-MBC influences patient's quality of life and it affects the use of resources in terms of both drugs and diagnostic exam prescription. We aim to disclose oncologists' approach on M-MBC, identifying controversial areas. METHODS: An anonymous online survey was conducted among GIM members who, based on their on-field experience, shared their own method for M-MBC planning...
April 18, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29679933/slip-avoidance-strategies-in-children-with-bilateral-spastic-cerebral-palsy-and-crouch-gait
#3
Ana Francisca Rozin Kleiner, Ilaria Pacifici, Claudia Condoluci, Chiarella Sforza, Manuela Galli
BACKGROUND: A slip occurs when the required friction (RCOF) to prevent slipping at the foot/floor interfaces exceeds the available friction. The RCOF is dependent upon the biomechanics features of individuals and their gait. On the other hand, the available friction depends on environmental features. Once individuals with crouch gait have their biomechanics of gait completely altered, how do they interact with a supporting surface? The aim was to quantify the RCOF in children with bilateral spastic cerebral palsy (BSCP) and crouch gait...
April 11, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29679921/electromyographic-and-biomechanical-analysis-of-step-negotiation-in-charcot-marie-tooth-subjects-whose-level-walk-is-not-impaired
#4
Tiziana Lencioni, Giuseppe Piscosquito, Marco Rabuffetti, Enrica Di Sipio, Manuela Diverio, Isabella Moroni, Luca Padua, Emanuela Pagliano, Angelo Schenone, Davide Pareyson, Maurizio Ferrarin
BACKGROUND: Charcot-Marie-Tooth (CMT) is a slowly progressive disease characterized by muscular weakness and wasting with a length-dependent pattern. Mildly affected CMT subjects showed slight alteration of walking compared to healthy subjects (HS). RESEARCH QUESTION: To investigate the biomechanics of step negotiation, a task that requires greater muscle strength and balance control compared to level walking, in CMT subjects without primary locomotor deficits (foot drop and push off deficit) during walking...
April 13, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29679917/possible-impacts-of-sea-level-rise-on-disease-transmission-and-potential-adaptation-strategies-a-review
#5
REVIEW
Ana C Dvorak, Helena M Solo-Gabriele, Andrea Galletti, Bernardo Benzecry, Hannah Malone, Vicki Boguszewski, Jason Bird
Sea levels are projected to rise in response to climate change, causing the intrusion of sea water into land. In flat coastal regions, this would generate an increase in shallow water covered areas with limited circulation. This scenario raises a concern about the consequences it could have on human health, specifically the possible impacts on disease transmission. In this review paper we identified three categories of diseases which are associated with water and whose transmission can be affected by sea level rise...
April 18, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29679916/a-novel-framework-for-the-use-of-remote-sensing-for-monitoring-catchments-at-continental-scales
#6
A B Bugnot, M B Lyons, P Scanes, G F Clark, S K Fyfe, A Lewis, E L Johnston
Historical ecology can teach us valuable lessons on the processes and drivers of environmental change that can inform future monitoring priorities and management strategies. Environmental data to study environmental history, however, is often absent or of low quality. Even when studying changes occurring during the last few decades, monitoring efforts are scarce due to logistical and cost limitations, leaving large areas unassessed. The aim of this study is to evaluate the use of estuarine water colour as an indicator of historical environmental change in catchments...
April 18, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29679856/b7-h6-expression-is-induced-by-lipopolysaccharide-and-facilitates-cancer-invasion-and-metastasis-in-human-gliomas
#7
Fengyuan Che, Xiaoli Xie, Long Wang, Quanping Su, Feiyu Jia, Yufu Ye, Lanlan Zang, Jing Wang, Hongyan Li, Yanchun Quan, Cuiping You, Jiawei Yin, Zhiqiang Wang, Gen Li, Yifeng Du, Lijuan Wang
Although great progress has been made in treatment regimens, gliomas are still incurable and the 5-year survival remains poor. Studies focusing on molecules that regulate tumorigenesis or tumor immunity may provide potential therapeutic strategies for patients with glioma. B7-H6 is selectively expressed in tumor cells and plays vital roles in host immune responses. In this study, we demonstrated that B7-H6 was expressed in glioma cell lines, including CRT, U251, SHG-44, SF-295, TG-905 and U373, and tumor tissues isolated from glioma patients...
April 18, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29679852/accident-analysis-to-support-the-development-of-strategies-for-the-prevention-of-brain-injuries-in-car-crashes
#8
Jacobo Antona-Makoshi, Koji Mikami, Mats Lindkvist, Johan Davidsson, Sylvia Schick
This study estimated the frequency and risk of Moderate-to-Maximal traumatic brain injuries sustained by occupants in motor vehicle crashes in the US. National Automotive Sampling System - Crashworthiness Data System crashes that occurred in years 2001-2015 with light vehicles produced 2001 or later were incorporated in the study. Crash type, crash severity, car model year, belt usage and occupant age and sex were controlled for in the analysis. The results showed that Moderate concussions account for 79% of all MAISbrain 2+ injuries...
April 18, 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29679848/a-deep-boltzmann-machine-driven-level-set-method-for-heart-motion-tracking-using-cine-mri-images
#9
Jian Wu, Thomas R Mazur, Su Ruan, Chunfeng Lian, Nalini Daniel, Hilary Lashmett, Laura Ochoa, Imran Zoberi, Mark A Anastasio, H Michael Gach, Sasa Mutic, Maria Thomas, Hua Li
Heart motion tracking for radiation therapy treatment planning can result in effective motion management strategies to minimize radiation-induced cardiotoxicity. However, automatic heart motion tracking is challenging due to factors that include the complex spatial relationship between the heart and its neighboring structures, dynamic changes in heart shape, and limited image contrast, resolution, and volume coverage. In this study, we developed and evaluated a deep generative shape model-driven level set method to address these challenges...
April 6, 2018: Medical Image Analysis
https://www.readbyqxmd.com/read/29679824/extended-producer-responsibility-and-corporate-performance-effects-of-environmental-regulation-and-environmental-strategy
#10
Benhong Peng, Yu Tu, Ehsan Elahi, Guo Wei
While contemporary manufacturing technologies stimulate the industrial revolution and promote the rapidly changing global economy, it has caused enormous environmental negative externalities and managing the industrial waste remains a primary challenge, especially for fast developing countries such as China. Though existing studies explored the influence of Extended Producer Responsibility (EPR) legislations on environmental externalities, only fewer researches aimed at policy issues. Particularly, the relationship among environmental regulations, environmental strategies and corporate performance in the EPR system has not been deeply investigated...
April 18, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29679822/advanced-strategies-to-improve-nitrification-process-in-sequencing-batch-reactors-a-review
#11
REVIEW
Francisco Jaramillo, Marcos Orchard, Carlos Muñoz, Mauricio Zamorano, Christian Antileo
The optimization of biological nitrogen removal (BNR) in sequencing batch reactors has become the aim of researchers worldwide in order to increase efficiency and reduce energy and operating costs. This research has focused on the nitrification phase as the limiting reaction rate of BNR. This paper analyzes different strategies and discusses different tools such as: factors for achieving partial nitrification, real-time control and monitoring for detecting characteristic patterns of nitrification/denitrification as end-points, use of modeling based on activated sludge models, and the use of data-driven modeling for estimating variables that cannot be easily measured experimentally or online...
April 18, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29679811/hepatitis-c-care-continuum-and-associated-barriers-among-people-who-inject-drugs-in-chennai-india
#12
Eshan U Patel, Sunil S Solomon, Allison M Mcfall, Aylur K Srikrishnan, Amrose Pradeep, Paneerselvam Nandagopal, Oliver Laeyendecker, Aaron A R Tobian, David L Thomas, Mark S Sulkowski, M Suresh Kumar, Shruti H Mehta
BACKGROUND: Little is known regarding barriers to hepatitis C virus (HCV) treatment among people who inject drugs (PWID) in low-resource settings, particularly in the era of direct-acting antiviral therapies. METHODS: Between March, 2015-August, 2016, a cross-sectional survey was administered to community-based PWID in Chennai, India to examine the HCV care continuum and associated barriers. Adjusted prevalence ratios (APR) were estimated by multivariable Poisson regression with robust variance...
April 18, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29679795/self-controlled-release-of-oxaliplatin-prodrug-from-d-%C3%AE-tocopheryl-polyethylene-glycol-1000-succinate-tpgs-functionalized-mesoporous-silica-nanoparticles-for-cancer-therapy
#13
Chaoyu Liang, Heping Wang, Min Zhang, Wei Cheng, Zihuang Li, Junpeng Nie, Gan Liu, Daizheng Lian, Zhenhua Xie, Laiqiang Huang, Xiaowei Zeng
Oxaliplatin is a promising antitumor drug, but its effectiveness is limited by its side effects in vivo. In this study, we introduced an Oxaliplatin prodrug (Oxa(IV)) self-controlled release strategy, in which Oxa(IV) is encapsulated by TPGS functionalized mesoporous silica nanoparticles (MSNs), and its release is controlled by biological stimuli, such as acidic environments in tumor tissue and high concentrations of reductants in cancer cells. Despite the lack of auxiliary "gatekeepers" to MSNs, this simplified model of Oxa(IV)-MSNs-TPGS could fine-tune the movements of the drug release...
April 16, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29679794/multi-paratopic-vegf-decoy-receptor-have-superior-anti-tumor-effects-through-anti-egfrs-and-targeted-anti-angiogenic-activities
#14
Dae Hee Lee, Myeong Youl Lee, Youngsuk Seo, Hyo Jeong Hong, Hyun Joo An, Jong Soon Kang, Ho Min Kim
Limitation of current anti-Vascular Endothelial Growth Factor (VEGF) cancer therapy is transitory responses, inevitable relapses and its insufficient tumor-targeting. Thus, multifaceted approaches, including the development of bispecific antibodies and combination strategies targeting different pathways have been proposed as an alternative. Here, we developed a novel multi-paratopic VEGF decoy receptor, Cetuximab-VEGF-Grab and Trastuzumab-VEGF-Grab, by genetically fusing VEGF decoy receptor (VEGF-Grab) to a single chain Fv of anti-Epidermal Growth Factor Receptor (EGFR) antibody (Cetuximab and Trastuzumab)...
April 16, 2018: Biomaterials
https://www.readbyqxmd.com/read/29679784/a-swinging-seesaw-as-a-novel-model-mechanism-for-time-dependent-hormesis-under-dose-dependent-stimulatory-and-inhibitory-effects-a-case-study-on-the-toxicity-of-antibacterial-chemicals-to-aliivibrio-fischeri
#15
Haoyu Sun, Edward J Calabrese, Min Zheng, Dali Wang, Yongzheng Pan, Zhifen Lin, Ying Liu
Hormesis occurs frequently in broadly ranging biological areas (e.g. plant biology, microbiology, biogerontology), toxicology, pharmacology and medicine. While numerous mechanisms (e.g. receptor and pathway mediated pathway responses) account for stimulatory and inhibitory features of hormetic dose responses, the vast majority emphasizes the inclusion of many doses but only one timepoint or use of a single optimized dose that is assessed over a broad range of timepoints. In this paper, a toxicity study was designed using a large number of properly spaced doses with responses determined over a large number of timepoints, which could help us reveal the underlying mechanism of hormesis...
April 10, 2018: Chemosphere
https://www.readbyqxmd.com/read/29679781/fronto-ethmoidal-osteoma-with-secondary-intradural-mucocele-extension-causing-frontal-lobe-syndrome-and-pneumocephalus-case-report-and-review-of-the-literature
#16
Licci Maria, Zweifel Christian, Hench Jürgen, Guzman Raphael, Soleman Jehuda
BACKGROUND: Paranasal sinus osteoma is a common, asymptomatic, histologically benign, and slow-growing tumor. However, it can give rise to secondary pathologies such as a mucocele in about 50% of the cases. Rarely, intracranial and orbital extension is present leading to rhinoliquorrhea, pneumocephalus, or neurological and visual impairment, which might be potentially life-threatening. CASE DESCRIPTION: A 49-year old man presented with an acute frontal lobe syndrome and rhinoliquorrhea...
April 18, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29679779/biomimetic-3d-in-vitro-model-of-biofilm-triggered-osteomyelitis-for-investigating-hematopoiesis-during-bone-marrow-infections
#17
Annamarija Raic, Sophie Riedel, Elena Kemmling, Karen Bieback, Joerg Overhage, Cornelia Lee-Thedieck
In this work, we define the requirements for a human-based osteomyelitis model which overcomes the limitations of state of the art animal models. Osteomyelitis is a severe and difficult to treat infection of the bone that develops rapidly, making it difficult to study in humans. We have developed a 3D in vitro model of the bone marrow, comprising a macroporous material, human hematopoietic stem and progenitor cells (HSPCs) and mesenchymal stromal cells (MSCs). Inclusion of biofilms grown on an implant into the model system allowed us to study the effects of postoperative osteomyelitis-inducing bacteria on the bone marrow...
April 18, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29679778/recapitulating-spatiotemporal-tumor-heterogeneity-in-vitro-through-engineered-breast-cancer-microtissues
#18
Claudia Mazio, Costantino Casale, Giorgia Imparato, Francesco Urciuolo, Paolo Antonio Netti
Tumor and microenvironmental heterogeneity hinders the study of breast cancer biology and the assessment of therapeutic strategies, being associated with high variability and drug resistance. In this context, it is mandatory to develop three-dimensional breast tumor models able to reproduce this heterogeneity and the dynamic interaction occurring between tumor cells and microenvironment. Here we show a new breast cancer microtissue model (T-µTP) uniquely able to present intra-tumor morphological heterogeneity in a dynamic and responsive endogenous matrix...
April 18, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29679761/expression-profiling-and-microbial-ligand-binding-analysis-of-high-mobility-group-box-1-hmgb1-in-turbot-scophthalmus-maximus-l
#19
Xin Cai, Chengbin Gao, Baofeng Su, Fenghua Tan, Ning Yang, Guodong Wang
High-mobility group box 1 (HMGB1), a highly conserved DNA-binding protein, was involved in nucleosome formation and transcriptional regulation, and can also act as an extracellular cytokine to trigger inflammation and immune responses. In this study, we identified a HMGB1 gene in turbot (Scophthalmus maximus L.). The full-length SaHMGB1 cDNA includes an open reading frame of 615 bp which encoded a 204 amino acid polypeptide with an estimated molecular mass of 23.19°kDa. SaHMGB1 was most closely related to several fish HMGB1 and shared 74...
April 18, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29679747/age-hiv-status-and-research-context-determined-attrition-in-a-longitudinal-cohort-in-nigeria
#20
Eileen O Dareng, Yinka Olaniyan, Sally N Adebamowo, Olabimpe R Eseyin, Michael K Odutola, Elonna M Obiefuna, Richard A Offiong, Paul P Pharoah, Clement A Adebamowo
OBJECTIVE: We explored determinants of attrition a longitudinal cohort study in Nigeria. STUDY DESIGN AND SETTING: We enroled 1,020 women into a prospective study. Of these, 973 were eligible to return for follow-up. We investigated the determinants of attrition among eligible women using a sequential mixed methods design. We used logistic regression models to compare the baseline characteristics of responders and non-responders. At the end of the parent study, we conducted 4 focus group discussions and 8 key informant interviews with non-responders RESULTS: Of the 973 women included in the quantitative analysis, 26% were non-responders...
April 18, 2018: Journal of Clinical Epidemiology
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