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https://www.readbyqxmd.com/read/29245180/factors-influencing-cane-use-for-the-management-of-knee-osteoarthritis-a-cross-sectional-survey
#1
Julia Hart, Rana S Hinman, Ans Van Ginckel, Michelle Hall, Rachel Nelligan, Kim L Bennell
OBJECTIVE: To investigate demographic, symptom-related and cognitive determinants of cane use for knee osteoarthritis (OA) and prioritise the factors that could facilitate cane use in people with no previous cane use. METHODS: A survey of people aged ≥45 years with a clinical diagnosis of knee OA was conducted. The survey included two sections: i) demographic and cognitive determinants of cane use assessed via subscales of the Cane Cognitive Mediator Scale; ii) 19 statements, underpinned by the Behaviour Change Wheel theoretical framework, relating to factors that could facilitate regular cane use...
December 15, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29245178/transcriptional-regulation-of-cd4-t-cell-differentiation-in-experimentally-induced-arthritis-and-rheumatoid-arthritis
#2
REVIEW
Yuya Kondo, Masahiro Yokosawa, Shunta Kaneko, Kotona Furuyama, Seiji Segawa, Hiroto Tsuboi, Isao Matsumoto, Takayuki Sumida
Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by infiltration of the joint synovium by activated inflammatory cells. CD4+ T cells form a large proportion of the inflammatory cells invading the synovial tissue, and are involved in the RA pathological process. In general, CD4+ T cells differentiate into various T helper (Th) cell subsets and acquire the functional characterization to respond to specific pathogens, and also mediated some autoimmune disorders such as RA. Because the differentiation of Th cell subsets is determined by the expression of specific transcription factors in response to cytokine environment, these transcription factors is considered to have a role in pathology of RA...
December 15, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29245156/selection-and-targeting-of-epcam-protein-by-ssdna-aptamer
#3
Walhan Alshaer, Nida Ababneh, Mamon Hatmal, Heba Izmirli, Moujab Choukeife, Alaa Shraim, Nour Sharar, Aya Abu-Shiekah, Fadwa Odeh, Abeer Al Bawab, Abdalla Awidi, Said Ismail
Aptamers are molecules that reveal highly complex and refined molecular recognition properties. These molecules are capable of binding with high affinity and selectivity to targets, ranging from small molecules to whole living cells. Several aptamers have been selected for targeting cellular proteins and they have also used in developing therapeutics and diagnostic strategies. Epithelial cell adhesion molecule (EpCAM) is considered as a cancer stem cell (CSC) biomarker and one of the most promising targets for aptamer selection against CSCs...
2017: PloS One
https://www.readbyqxmd.com/read/29245154/acute-procedural-outcomes-of-orbital-atherectomy-for-the-treatment-of-profunda-femoris-artery-disease-subanalysis-of-the-confirm-registries
#4
Michael S Lee, Pratyaksh K Srivastava, Saif Al Yaseen, Daniel Heikali, John Hollowed, Ehtisham Mahmud
OBJECTIVES: We compared the angiographic outcomes of patients treated with orbital atherectomy for profunda femoris artery (PFA) and superficial femoral artery (SFA) disease from the CONFIRM I-III registries. BACKGROUND: Endovascular revascularization of the PFA is considered a high-risk procedure given that it is an important collateral vessel when the SFA becomes occluded. Data on outcomes of endovascular revascularization of calcified PFA disease are limited...
December 15, 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29245137/synthesis-of-the-repeating-unit-of-o-specific-polysaccharide-isolated-from-the-water-borne-bacteria-aeromonas-bestiarum-207
#5
Yiren Xu, Guanghui Zong, Shuhui Jin, Jianjun Zhang
Aeromonas bestiarum 207 is a bacterial pathogen with severe impact on aquaculture. In a recent study, the structure of OPS antigens from Aeromonas bestiarum was identified as pentasaccharide repeating units. Synthesis of the pentasaccharide repeating unit and its derivative are reported. Stereo- and regio-specific synthesis was achieved under Schmidt glycosylation conditions employing appropriately protected L-rhamopyranosyl and D-glucopyranosylamine building blocks. The pentasaccharide synthesis was achieved using a [3 + 2] strategy with an overall yield of 5...
November 21, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/29245119/dceus-based-focal-parametric-perfusion-imaging-of-microvessel-with-single-pixel-resolution-and-high-contrast
#6
Diya Wang, Mengnan Xiao, Hong Hu, Yu Zhang, Zhe Su, Shanshan Xu, Yujin Zong, Mingxi Wan
This study aimed to develop a focal microvascular contrast-enhanced ultrasonic parametric perfusion imaging (PPI) scheme to overcome the tradeoff between the resolution, contrast, and accuracy of focal PPI in the tumor. Its resolution was limited by the low signal-to-clutter ratio (SCR) of time-intensity-curves (TICs) induced by multiple limitations, which deteriorated the accuracy and contrast of focal PPI. The scheme was verified by the in-vivo perfusion experiments. Single-pixel TICs were first extracted to ensure PPI with the highest resolution...
December 2, 2017: Ultrasonics
https://www.readbyqxmd.com/read/29245111/community-based-rehabilitation-offers-cost-effective-epilepsy-treatment-in-rural-guinea-bissau
#7
Eric van Diessen, Frank van der Maas, Vladimir Cabral, Willem M Otte
Treatment of epilepsy in low-income countries is a challenge considering the lack of resources, availability of antiepileptic drugs, and cultural beliefs. We used a community-based rehabilitation (CBR) service for the detection, monitoring, and treatment of epilepsy. A local network of trained community volunteers provided education, good quality antiepileptic drugs, and clinical follow-up for people with epilepsy (PWE). In a period of 2years, approximately 22,500 people were screened in central Guinea-Bissau, and 112 PWE were identified and registered...
December 12, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29245106/cerebral-arterio-venous-malformations-in-the-paediatric-population-angiographic-characteristics-multimodal-treatment-strategies-and-outcome
#8
Klaus-Peter Stein, Bernd-Otto Huetter, Sophia Goericke, Neriman Oezkan, Rebecca Leyrer, I Erol Sandalcioglu, Michael Forsting, Ulrich Sure, Oliver Mueller
OBJECTIVES: Cerebral arterio-venous malformations (AVM) are considered congenital lesions, emerging as an important cause of haemorrhagic stroke in children. The potential influence of age on clinical presentation and angio-architecture have been analysed extensively in the last years. Yet, comparative studies comprising ascending age groups may be limited in their conclusions, especially when comparing young children and adults. It is the aim of this study to evaluate characteristic clinical and angiographic features of AVM within a paediatric subgroup and their correlation to age at presentation...
December 5, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29245104/who-goes-first-understanding-hepatitis-c-risk-among-injecting-networks-in-the-prison-setting
#9
Lise Lafferty, Jake Rance, Carla Treloar
BACKGROUND: Hepatitis C (HCV) is a blood-borne virus that is most commonly transmitted through shared injecting equipment. Due to the criminalisation of injecting drug use, HCV is highly prevalent among those incarcerated. Using a risk environment framework, this qualitative study sought to understand the role of HCV risk within injecting networks in the prison setting. METHODS: Thirty-two adult prisoners (n=24 men; n=8 women) with a history of injecting drug use participated in this qualitative sub-study...
December 8, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29245090/psychological-distress-and-risk-for-suicidal-behavior-among-university-students-in-contemporary-china
#10
Fang Tang, Majella Byrne, Ping Qin
BACKGROUND: Psychological distress and suicidal behavior are important mental health problems among university students and warrant research to inform strategies for effective prevention in this young population. The present study aimed to assess psychological distress and suicidal behavior and to unravel their associations among university students. METHODS: A total of 5972 undergraduate students, randomly selected from six universities in central China, comprised the sample...
December 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29245088/-ghost-peak-of-clofazimine-a-solution-degradation-product-of-clofazimine-via-nucleophilic-substitution-by-nitrite-leaching-from-certain-glass-hplc-vials
#11
Jinsheng Lin, Zhenghuai Lin, Dan Li, Mengxue Feng, Qin Yang, Wenping Hu, Yang Han, Wenquan Zhu, Min Li, LuShan Yu
Analytical solutions of clofazimine drug substance stored in glass HPLC vials were found to undergo degradation at room temperature occasionally. At the time of each sample preparation, it was unpredictable if a particular solution would undergo such solution degradation. Once the degradation peak was observed in a particular vial, typically within 24h, it would keep growing until reaching a total yield of approximately 2%. By using a strategy that combines LC-PDA/UV-MSn with mechanism-based stress studies, followed by preparative HPLC separation and subsequent structure characterization by 1D and 2D NMR, the unknown peak was identified as a clofazimine nitrite ester...
November 26, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29245068/overexpression-of-microrna-375-impedes-platelet-derived-growth-factor-induced-proliferation-and-migration-of-human-fetal-airway-smooth-muscle-cells-by-targeting-janus-kinase-2
#12
Yamei Ji, Xin Yang, Huixia Su
The abnormal proliferation and migration of airway smooth muscle (ASM) cells play a critical role in airway remodeling during the development of asthma. MicroRNAs (miRNAs) have emerged as critical regulators of ASM cell proliferation and migration in airway remodeling. In this study, we aimed to investigate the potential role of miR-375 in the regulation of platelet-derived growth factor (PDGF)-induced fetal ASM cell proliferation and migration. Our results showed that miR-375 expression was significantly decreased in fetal ASM cells that were treated with PDGF...
December 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29245045/relations-between-problem-behaviors-perceived-symptom-severity-and-parenting-in-adolescents-and-emerging-adults-with-asd-the-mediating-role-of-parental-psychological-need-frustration
#13
Lisa M Dieleman, Sarah S W De Pauw, Bart Soenens, Elien Mabbe, Rachel Campbell, Peter Prinzie
Research in parents of youngsters with Autism Spectrum Disorder (ASD) increasingly documents associations between children's problem behaviors and symptom severity and more dysfunctional and less adaptive parenting behaviors. However, the mechanisms underlying these associations have not been examined thoroughly. This study examines the mediating role of parental need frustration in the relation between child maladjustment (i.e., problem behavior and autism severity) and parenting behavior (i.e., controlling and autonomy-supportive parenting)...
December 12, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29245022/cost-effective-way-to-reduce-stimulant-abuse-among-gay-bisexual-men-and-transgender-women-a-randomized-clinical-trial-with-a-cost-comparison
#14
S X Zhang, S Shoptaw, C J Reback, K Yadav, A M Nyamathi
OBJECTIVES: A randomized controlled study was conducted with 422 homeless, stimulant-using gay/bisexual (G/B) men and 29 transgender women (n = 451) to assess two community-based interventions to reduce substance abuse and improve health: (a) a nurse case-managed program combined with contingency management (NCM + CM) versus (b) standard education plus contingency management (SE + CM). STUDY DESIGN: Hypotheses tested included: a) completion of hepatitis A/B vaccination series; b) reduction in stimulant use; and c) reduction in number of sexual partners...
December 12, 2017: Public Health
https://www.readbyqxmd.com/read/29245004/a-standardized-preoperative-group-intervention-is-feasible-and-acceptable-to-orthognathic-surgery-patients
#15
Xialong Li, Debra L Safer, Imilce Castro Paz, Roseanne Menorca, Sabine Girod
PURPOSE: Nearly 10% of patients remain dissatisfied after orthognathic surgery, largely because of psychoeducational or psychosocial factors. The purpose of this study was to evaluate the feasibility and acceptability of a psychoeducationally based group intervention to improve preoperative preparation of orthognathic surgical patients and their caregivers. MATERIALS AND METHODS: The intervention consisted of 2 group sessions, with each session lasting 2 hours...
November 22, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29245000/does-traumatic-brain-injury-hold-the-key-to-the-alzheimer-s-puzzle
#16
Robert E Becker, Dimitrios Kapogiannis, Nigel H Greig
INTRODUCTION: Neurodegenerative disorders have been a graveyard for hundreds of well-intentioned efforts at drug discovery and development. Concussion and other traumatic brain injuries (TBIs) and Alzheimer's disease (AD) share many overlapping pathologies and possible clinical links. METHODS: We searched the literature since 1995 using MEDLINE and Google Scholar for the terms concussion, AD, and shared neuropathologies. We also studied a TBI animal model as a supplement to transgenic (Tg) mouse AD models for evaluating AD drug efficacy by preventing neuronal losses...
December 12, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29244995/proceedings-of-the-strategy-meeting-for-the-development-of-an-international-consortium-for-chinese-medicine-and-cancer
#17
Jeffrey D White, Hongsheng Lin, Libin Jia, Roy S Wu, Stephen Lam, Jie Li, Jinhui Dou, Nagi Kumar, Lizhu Lin, Lixing Lao
On November 3, 2014, in Bethesda, MD, the Office of Cancer Complementary and Alternative Medicine of the National Cancer Institute held a meeting to examine the potential utility and feasibility of establishing an international consortium for Chinese medicine and cancer. There is significant interest in the West in using components of Chinese medicine (CM) -such as botanicals and herbal medicines, acupuncture and acupressure, and qigong-in the field of oncology, as potential anticancer agents, for symptom management, and to improve quality of life...
December 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29244993/cervical-cancer-in-the-greater-accra-and-ashanti-regions-of-ghana
#18
Yvonne Nartey, Philip C Hill, Kwabena Amo-Antwi, Kofi M Nyarko, Joel Yarney, Brian Cox
Purpose Cervical cancer is a common cancer among women worldwide. An estimated 528,000 new cases and 266,000 deaths occurred in 2012. More than 85% of invasive cervical cancer cases occur in low- and middle-income countries. Cervical cancer ranks as the most common cancer among women in Ghana. We conducted a retrospective study to assess the descriptive epidemiology of cervical cancer in Ghana. We describe cervical cancer incidence and mortality rates for the regions served by two large hospitals in Ghana. Patients and Methods Information for women diagnosed with invasive cervical cancer between 2010 and 2013 was collected from the Komfo Anokye and Korle Bu Teaching Hospitals through review of medical, computer, and pathology records at the oncology units and the obstetrics and gynecology departments...
December 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29244989/global-use-of-traditional-and-complementary-medicine-in-childhood-cancer-a-systematic-review
#19
Caroline Diorio, Catherine G Lam, Elena J Ladas, Festus Njuguna, Glenn M Afungchwi, Katherine Taromina, Stacey Marjerrison
Purpose Traditional and complementary medicine (T&CM) strategies are commonly used in pediatric oncology. Patterns may vary based on country income. We systematically reviewed published studies describing T&CM use among pediatric oncology patients in low-income countries (LIC/LMIC), middle-income countries (UMIC), and high-income countries (HIC). Objectives included describing estimated prevalence of use, reasons for use, perceived effectiveness, modalities used, rates of disclosure, and reporting of delayed or abandoned treatment...
December 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29244983/allogeneic-stem-cell-transplant-for-acute-myeloid-leukemia-evolution-of-an-effective-strategy-in-india
#20
Abhijeet Ganapule, Sandeep Nemani, Anu Korula, Kavitha M Lakshmi, Aby Abraham, Alok Srivastava, Poonkuzhali Balasubramanian, Biju George, Vikram Mathews
Purpose There are limited data from developing countries on the role and cost-effectiveness of allogeneic stem cell transplantation (allo-SCT) for patients with acute myeloid leukemia (AML). Patients and Methods We undertook a retrospective descriptive study of all patients with AML who underwent allo-SCT from 1994 to 2013 at our center to evaluate the clinical outcomes and cost-effectiveness of this therapeutic modality. Results Two hundred fifty-four consecutive patients, median age 34 years, who underwent allo-SCT at our center were included in this study...
December 2017: Journal of Global Oncology
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