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https://www.readbyqxmd.com/read/28823137/survey-of-genetic-structure-of-geese-using-novel-microsatellite-markers
#1
Fang-Yu Lai, Po-An Tu, Shih-Torng Ding, Min-Jung Lin, Shen-Chang Chang, En-Chung Lin, Ling-Ling Lo, Pei-Hwa Wang
Objective: The aim of this study was to create a set of microsatellite markers with high polymorphism for the genetic monitoring and genetic structure analysis of local goose populations. Methods: Novel microsatellite markers were isolated from the genomic DNA of white Roman geese using short tandem repeated probes. The DNA segments, including short tandem repeats, were tested for their variability among four populations of geese from the Changhua Animal Propagation Station (CAPS)...
August 16, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28823130/use-of-alternative-curing-salts-for-processing-salamis
#2
Dong-Gyun Yim, Ku-Young Chung, Cheorun Jo, Ki-Chang Nam
Objective: This study was performed to determine effects of different curing salts on the quality of salamis and to assess feasibility of using NaCl-alternative salts. Methods: Various types of curing salts (KCl or MgCl2) as well as NaCl (sun-dried or refined) were incorporated for processing of salamis. The proximate composition, fatty acids, nucleotide-related compounds, and free amino acids of the salamis were analyzed during 40 days of ripening. Results: The substitution of NaCl by KCl caused higher fat and ash content, but lower moisture content of the salami after 20 days of ripening (p<0...
August 16, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28823109/comparison-of-two-home-sleep-testing-devices-with-different-strategies-for-diagnosis-of-osa
#3
Tyler Gumb, Akosua Twumasi, Shahnaz Alimokhtari, Alan Perez, Kathleen Black, David M Rapoport, Jag Sunderram, Indu Ayappa
PURPOSE: Home sleep testing devices are being widely used in diagnosis/screening for obstructive sleep apnea (OSA). We examined differences in OSA metrics obtained from two devices with divergent home monitoring strategies, the Apnea Risk Evaluation System (ARES™, multiple signals plus forehead reflectance oximetry) and the Nonin WristOx2™ (single channel finger transmission pulse oximeter), compared to differences from night-night variability of OSA. METHODS: One hundred fifty-two male/26 female subjects (BMI = 30...
August 19, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28823101/predictors-of-disordered-eating-in-young-males
#4
R Doumit, J Abi Kharma, M J Sanchez-Ruiz, N Zeeni
Recent findings suggest that disordered eating (DE) symptomatology may be underestimated in the male population. The present study examined depressive symptomatology as a potential mediator of the relationships between body image dissatisfaction, strategies to change body weight and muscles, media pressure, and DE (emotional, restrained and emotional eating) in 260 male undergraduates who completed a self-reported questionnaire. Path analyses indicated that media influence and strategies to decrease body weight had direct positive effects on depressive symptomatology, which in turn predicted emotional eating...
August 19, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/28823073/effect-of-low-level-laser-therapy-%C3%AE-780%C3%A2-nm-on-the-mechanically-damaged-dentin-pulp-complex-in-a-model-of-extrusive-luxation-in-rat-incisors
#5
Dandara Andrade de Santana, Gabriela Ferraz Fonseca, Luciana Maria Pedreira Ramalho, Tânia Tavares Rodriguez, Marcio Cajazeira Aguiar
In order to regenerate the dental pulp, many strategies have been developed as phototherapy. In the pulp repair, we do not know if gallium-aluminum-arsenide (GaAlAs) laser preserves the primary odontoblasts or stimulates the formation of more dentin matrix when dental pulp is damaged. The aim of the present study was to examine the effect of laser phototherapy (λ780 nm) on vascularization, inflammation, density of the primary odontoblast layer, and formation of reactionary and reparative dentin in the dental pulp by provoking extrusion of the rat incisor...
August 19, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28823071/accelerating-the-integration-of-distributed-water-solutions-a-conceptual-financing-model-from-the-electricity-sector
#6
Kimberly J Quesnel, Newsha K Ajami, Noemi Wyss
Modern challenges require new approaches to urban water management. One solution in the portfolio of potential strategies is the integration of distributed water infrastructure, practices, and technologies into existing systems. However, many practical barriers have prevented the widespread adoption of these systems in the US. The objective of this paper is to address these challenges by developing a conceptual model encompassing regulatory, financial, and governance components that can be used to incorporate new distributed water solutions into our current network...
August 19, 2017: Environmental Management
https://www.readbyqxmd.com/read/28823047/knowledge-that-acts-evaluating-the-outcomes-of-a-knowledge-brokering-intervention-in-western-australia-s-ningaloo-region
#7
Kelly Chapman, Fabio Boschetti, Elizabeth Fulton, Pierre Horwitz, Tod Jones, Pascal Scherrer, Geoff Syme
Knowledge exchange involves a suite of strategies used to bridge the divides between research, policy and practice. The literature is increasingly focused on the notion that knowledge generated by research is more useful when there is significant interaction and knowledge sharing between researchers and research recipients (i.e., stakeholders). This is exemplified by increasing calls for the use of knowledge brokers to facilitate interaction and flow of information between scientists and stakeholder groups, and the integration of scientific and local knowledge...
August 19, 2017: Environmental Management
https://www.readbyqxmd.com/read/28823011/guidelines-versus-reality-is-coronary-stent-application-in-three-vessel-disease-standard-or-the-exception
#8
Roland Linder, J Zeidler, F Verheyen, J-M Graf von der Schulenburg, A Haverich, T Schilling
The national guidelines for treatment of chronic coronary heart disease (CHD) recommend surgical coronary aortic bypass grafting (CABG) rather than percutaneous coronary intervention (PCI) for patients with a coronary three-vessel disease. The epidemiology of three-vessel CHD and data about the application of different revascularisation strategies raise suspicion of deviation from the guidelines in the treatment of those patients. Claims data containing records of almost 10 million patients of the largest German statutory health insurance fund (Techniker Krankenkasse) were utilised to measure adherence to the guidelines for treatment of groups of patients with one-, two-, and three-vessel CHD, respectively...
August 19, 2017: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/28823006/impact-of-gleason-score-on-biochemical-recurrence-in-patients-with-pt3an0-nx-prostate-cancer-with-positive-surgical-margins-a-multicenter-study-from-the-prostate-cancer-research-committee
#9
Wan Song, Dong Hyeon Lee, Hwang Gyun Jeon, Byong Chang Jeong, Seong Il Seo, Hyun Moo Lee, Han Yong Choi, Jong Wook Kim, SangChul Lee, Seok-Soo Byun, Chang Wook Jeong, Cheol Kwak, Jin Seon Cho, Hanjong Ahn, Seong Soo Jeon
PURPOSE: Oncologic outcomes of patients with pT3aN0/Nx prostate cancer (PCa) with positive surgical margins (PSM) after radical prostatectomy (RP) are heterogeneous. We investigated the impact of Gleason score (GS) on biochemical recurrence (BCR) in these patients. METHODS: A retrospective, multicenter study was performed on 795 patients with pT3aN0/Nx PCa with PSM after RP between January 2006 and December 2014. Clinicopathologic characteristics of patients were examined and onset of BCR was identified...
August 19, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28822996/examining-bias-in-studies-of-statin-treatment-and-survival-in-patients-with-cancer
#10
Louise Emilsson, Xabier García-Albéniz, Roger W Logan, Ellen C Caniglia, Mette Kalager, Miguel A Hernán
Importance: Patients with cancer who use statins appear to have a substantially better survival than nonusers in observational studies. However, this inverse association between statin use and mortality may be due to selection bias and immortal-time bias. Objective: To emulate a randomized trial of statin therapy initiation that is free of selection bias and immortal-time bias. Design, Setting, and Participants: We used observational data on 17 372 patients with cancer from the Surveillance, Epidemiology, and End Results (SEER)-Medicare database (2007-2009) with complete follow-up until 2011...
August 20, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28822989/cellular-prion-protein-enhances-drug-resistance-of-colorectal-cancer-cells-via-regulation-of-a-survival-signal-pathway
#11
Jun Hee Lee, Chul Won Yun, Sang Hun Lee
Anti-cancer drug resistance is a major problem in colorectal cancer (CRC) research. Although several studies have revealed the mechanism of cancer drug resistance, molecular targets for chemotherapeutic combinations remain elusive. To address this issue, we focused on the expression of cellular prion protein (PrP(C)) in 5-FU-resistant CRC cells. In 5-FU-resistant CRC cells, PrP(C) expression is significantly increased, compared with that in normal CRC cells. In the presence of 5-FU, PrP(C) increased CRC cell survival and proliferation by maintaining the activation of the PI3K-Akt signaling pathway and the expression of cell cycle-associated proteins, including cyclin E, CDK2, cyclin D1, and CDK4...
August 21, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28822936/influence-of-coupled-ocean-atmosphere-phenomena-on-the-greater-horn-of-africa-droughts-and-their-implications
#12
Freddie Mpelasoka, Joseph L Awange, Ayalsew Zerihun
Drought-like humanitarian crises in the Greater Horn of Africa (GHA) are increasing despite recent progress in drought monitoring and prediction efforts. Notwithstanding these efforts, there remain challenges stemming from uncertainty in drought prediction, and the inflexibility and limited buffering capacity of the recurrent impacted systems. The complexity of the interactions of ENSO, IOD, IPO and NAO, arguably remains the main source of uncertainty in drought prediction. To develop practical drought risk parameters that potentially can guide investment strategies and risk-informed planning, this study quantifies, drought characteristics that underpin drought impacts management...
August 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28822928/combined-effects-of-salinity-temperature-and-hypoxia-on-daphnia-magna-metabolism
#13
Elba Garreta-Lara, Bruno Campos, Carlos Barata, Silvia Lacorte, Romà Tauler
Metabolic changes of Daphnia magna pools due different abiotic factors linked to global climate change (salinity, temperature and hypoxia) were investigated using untargeted GC-MS and advanced chemometric strategies using a three factors two-level full factorial experimental design (DoE). Effects of these three factors and identity of the metabolites whose concentrations changed because of them were investigated. The simultaneous analysis of GC-MS data sets using Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS) allowed the resolution of the elution and mass spectra profiles of a large number of D...
August 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28822889/metformin-targets-gastric-cancer-stem-cells
#14
Sarah Courtois, Raúl V Durán, Julie Giraud, Elodie Sifré, Julien Izotte, Francis Mégraud, Philippe Lehours, Christine Varon, Emilie Bessède
Gastric cancer is the third leading cause of cancer-related deaths worldwide and has still a poor prognosis. Therefore, new therapeutic strategies are needed: among them, targeting cancer stem cells (CSCs) could offer new opportunities. The aim of our study was to evaluate the anti-tumoural effect of metformin on gastric cancer in vitro and in vivo and especially, to determine whether this molecule could target the gastric CSCs. Metformin effects were evaluated on the proliferation and tumourigenic properties of the gastric CSCs from patient-derived primary tumour xenografts (PDXs) and cancer cell lines (MKN45, AGS and MKN74) in vitro in conventional 2 dimensional (2D) and in 3 dimensional (3D) culture systems, in which only CSCs are able to form tumourspheres and in mouse xenograft models in vivo...
August 17, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28822887/the-changing-diagnostic-pathway-for-lung-cancer-patients-in-shanghai-china
#15
REVIEW
Tao Jiang, Shengxiang Ren, Xuefei Li, Chunxia Su, Caicun Zhou, Mary O'Brien
Accumulating evidence suggest that patients with advanced non-small-cell lung cancer (NSCLC) and specific genomic alterations including epidermal growth factor receptor and microtubule-associated protein-like 4 anaplastic lymphoma kinase could significantly benefit from molecular-targeted therapies compared with chemotherapy. Recently, immunotherapy based on programmed cell death 1 (PD-1) and its ligand (PD-L1) blockade prolong survival in patients with advanced NSCLC, especially in those patients with positive expression of PD-L1 and when used in the first-line setting...
August 17, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28822879/patient-recall-of-specific-cognitive-therapy-contents-predicts-adherence-and-outcome-in-adults-with-major-depressive-disorder
#16
Lu Dong, Xin Zhao, Stacie L Ong, Allison G Harvey
The current study examined whether and which specific contents of patients' memory for cognitive therapy (CT) were associated with treatment adherence and outcome. Data were drawn from a pilot RCT of forty-eight depressed adults, who received either CT plus Memory Support Intervention (CT + Memory Support) or CT-as-usual. Patients' memory for treatment was measured using the Patient Recall Task and responses were coded into cognitive behavioral therapy (CBT) codes, such as CBT Model and Cognitive Restructuring, and non-CBT codes, such as individual coping strategies and no code...
August 10, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28822875/a-consortium-driven-framework-to-guide-the-implementation-of-ich-m7-option-4-control-strategies
#17
Chris Barber, Vincent Antonucci, Jens-Christoph Baumann, Roland Brown, Elizabeth Covey-Crump, David Elder, Eric Elliott, Jared W Fennell, Fabrice Gallou, Nathan D Ide, Guido Jordine, Jeffrey M Kallemeyn, Dirk Lauwers, Adam R Looker, Lucie E Lovelle, Mark McLaughlin, Robert Molzahn, Martin Ott, Didier Schils, Rolf Schulte Oestrich, Neil Stevenson, Pere Talavera, Andrew Teasdale, Michael W Urquhart, David L Varie, Dennie Welch
The ICH M7 Option 4 control of (potentially) mutagenic impurities is based on the use of scientific principles in lieu of routine analytical testing. This approach can reduce the burden of analytical testing without compromising patient safety, provided a scientifically rigorous approach is taken which is backed up by sufficient theoretical and/or analytical data. This paper introduces a consortium-led initiative and offers a proposal on the supporting evidence that could be presented in regulatory submissions...
August 16, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28822868/preliminary-profiling-of-microrna-in-the-normal-and-regenerating-liver-of-chiloscyllium-plagiosum
#18
Dandan Cheng, Yanna Chen, Conger Lu, Yuezhong Qian, Zhengbing Lv
Liver is a vital organ present in animals for detoxification, protein synthesis, digestion and other functions and its powerful regenerative capacity is well known. C. plagiosum is an abundant fish that is representative of the cartilaginous class in the southeast coastal region of China and its liver accounts for >70% of the fish's visceral weight and contains many bioactive substances. MicroRNAs (microRNAs) play important roles in a wide range of biological processes in eukaryotes, including cell proliferation, differentiation, apoptosis...
July 27, 2017: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
https://www.readbyqxmd.com/read/28822795/strategies-for-analyzing-bisulfite-sequencing-data
#19
Katarzyna Wreczycka, Alexander Gosdschan, Dilmurat Yusuf, Björn Grüning, Yassen Assenov, Altuna Akalin
DNA methylation is one of the main epigenetic modifications in the eukaryotic genome; it has been shown to play a role in cell-type specific regulation of gene expression, and therefore cell-type identity. Bisulfite sequencing is the gold-standard for measuring methylation over the genomes of interest. Here, we review several techniques used for the analysis of high-throughput bisulfite sequencing. We introduce specialized short-read alignment techniques as well as pre/post-alignment quality check methods to ensure data quality...
August 16, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28822781/inpatient-versus-outpatient-parenteral-antibiotic-therapy-at-home-for-acute-infections-in-children-a-systematic-review
#20
REVIEW
Penelope A Bryant, Naomi T Katz
Inpatient management is necessary in many situations, but medical and allied-health treatments are increasingly being used on an outpatient basis to allow patients who would traditionally have been admitted to hospital to remain at home. Home-based clinical management has many potential benefits, including reduced hospital-acquired infections, cost savings, and patient and family satisfaction. Studies in adults provide evidence for the benefits of home-based versus hospital-based intravenous antibiotics, but few studies inform practice in home-based intravenous antibiotic therapy for children...
August 16, 2017: Lancet Infectious Diseases
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