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https://www.readbyqxmd.com/read/28945048/-glass-transition-of-chinese-medicine-extract-powder-and-its-application
#1
Xiao-Jian Luo, Hui Liu, Hong-Bo Liang, Lei Xiong, Xiao-Yong Rao, Yin Xie, Yan He
Glass transition theory is an important theory in polymer science, which is used to characterize the physical properties. It refers to the transition of amorphous polymer from the glassy state to the rubber state due to heating or the transition from rubber state to glassy state due to cooling. In this paper, the glassy state and glass transition of food and the similar relationship between the composition of Chinese medicine extract powder and food ingredients were described; the determination method for glass transition temperature (Tg) of Chinese medicine extract powder was established and its main influencing factors were analyzed...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28945017/-a-strategy-of-constructing-the-technological-system-for-quality-control-of-chinese-medicine-based-on-process-control-and-management
#2
Yi-Yu Cheng, Zhong-Zhi Qian, Bo-Li Zhang
The current situation, bottleneck problems and severe challenges in quality control technology of Chinese Medicine (CM) are briefly described. It is presented to change the phenomenon related to the post-test as the main means and contempt for process control in drug regulation, reverse the situation of neglecting the development of process control and management technology for pharmaceutical manufacture and reconstruct the technological system for quality control of CM products. The regulation and technology system based on process control and management for controlling CM quality should be established to solve weighty realistic problems of CM industry from the root causes, including backwardness of quality control technology, weakness of quality risk control measures, poor reputation of product quality and so on...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28945016/cultural-hair-practices-physical-activity-and-obesity-among-urban-african-american-girls
#3
Felesia Bowen, Patricia O'Brien-Richardson
BACKGROUND AND PURPOSE: Hair holds cultural meaning and value for women of African descent. The values placed on hair type and hair style date back to preslavery days. There is a small body of literature that addresses the relationship between cultural hair practices and physical inactivity among black women. Understanding this is important because inactivity during childhood and adolescent years contributes to increased weight-related morbidity and mortality during adult years. The purpose of this study was to determine the relationship between cultural hair practices, physical activity, and obesity among urban African-American adolescent girls...
September 25, 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/28945014/a-reloadable-self-healing-hydrogel-enabling-diffusive-transport-of-c-dots-across-gel-gel-interface-for-scavenging-reactive-oxygen-species
#4
Jing Chen, Shuya Li, Ye Zhang, Wei Wang, Xiang Zhang, Yangyang Zhao, Yucai Wang, Hong Bi
While reloadable drug delivery platforms are highly prized for the treatment of a broad spectrum of diseases, the gel-gel interface between hydrogels hinders the intergel diffusive transport of drugs and thus limits the application of hydrogels as reloadable depots. Here, this study reports the circumvention of this barrier by employing a self-healing hydrogel prepared from N-carboxyethyl chitosan and sodium alginate dialdehyde, which are cross-linked via a reversible Schiff base linkage. The injectable and bioadhesive hydrogel shows a rapid gelation time of 47 s...
September 25, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28944980/failure-mode-and-effects-analysis-a-community-practice-perspective
#5
Bradley W Schuller, Angi Burns, Elizabeth A Ceilley, Alan King, Joan LeTourneau, Alexander Markovic, Lynda Sterkel, Brigid Taplin, Jennifer Wanner, Jeffrey M Albert
PURPOSE: To report our early experiences with failure mode and effects analysis (FMEA) in a community practice setting. METHODS: The FMEA facilitator received extensive training at the AAPM Summer School. Early efforts focused on department education and emphasized the need for process evaluation in the context of high profile radiation therapy accidents. A multidisciplinary team was assembled with representation from each of the major department disciplines. Stereotactic radiosurgery (SRS) was identified as the most appropriate treatment technique for the first FMEA evaluation, as it is largely self-contained and has the potential to produce high impact failure modes...
September 25, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28944973/a-full-pivoting-algorithm-for-the-cholesky-decomposition-of-two-electron-repulsion-and-spin-orbit-coupling-integrals
#6
Matteo Piccardo, Alessandro Soncini
A significant reduction in the computational effort for the evaluation of the electronic repulsion integrals (ERI) in ab initio quantum chemistry calculations is obtained by using Cholesky decomposition (CD), a numerical procedure that can remove the zero or small eigenvalues of the ERI positive (semi)definite matrix, while avoiding the calculation of the entire matrix. Conversely, due to its antisymmetric character, CD cannot be directly applied to the matrix representation of the spatial part of the two-electron spin-orbit coupling (2e-SOC) integrals...
September 25, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/28944962/hpv-e6-protein-enriches-the-cd55-population-in-cervical-cancer-cells-promoting-radio-resistance-and-cancer-aggressiveness
#7
Thomas Ho-Yin Leung, Hermit Wai-Man Tang, Michelle Kwan-Yee Siu, David Wai Chan, Karen Kar-Loen Chan, Annie Nga-Yin Cheung, Hextan Yuen-Sheung Ngan
Accumulating evidence indicates that the human papilloma virus (HPV) E6 protein plays a crucial role in the development of cervical cancer. Sub-populations of cells that reside within tumors are responsible for tumor resistance to cancer therapy and recurrence. However, the identity of such cells residing in cervical cancer and their relationship with the HPV-E6 protein have not been identified. Here, we isolated sphere-forming cells, which exhibited self-renewal ability, from primary cervical tumors. Gene expression profiling revealed that CD55 was upregulated in primary cervical cancer sphere cells...
September 25, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28944932/new-treatment-for-non-hodgkin-b-cell-lymphomas-with-a-special-focus-on-the-impact-of-junctional-adhesion-molecules
#8
Beat Albert Imhof, Thomas Matthes
Current therapeutic modalities used for B-cell lymphoma include chemotherapy, immunotherapy, and radiation therapy. Chemotherapy together with anti-CD20 monoclonal antibodies forms the cornerstone of therapy and has a curative, as well as a palliative, role in this disease. New treatment modalities targeting specific molecules on the surface of lymphoma cells or intracellular pathways regulating apoptosis, proliferation and cell division are intensively investigated. One such target is JAM-C, a molecule implicated in cell adhesion and in B cell migration and whose inhibition blocks B cells from reaching their supportive microenvironments in lymphoid organs...
September 25, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28944917/application-of-a-co%C3%A2-expression-network-for-the-analysis-of-aggressive-and-non%C3%A2-aggressive-breast-cancer-cell-lines-to-predict-the-clinical-outcome-of-patients
#9
Ling Guo, Kun Zhang, Zhitong Bing
Breast cancer metastasis is a demanding problem in clinical treatment of patients with breast cancer. It is necessary to examine the mechanisms of metastasis for developing therapies. Classification of the aggressiveness of breast cancer is an important issue in biological study and for clinical decisions. Although aggressive and non‑aggressive breast cancer cells can be easily distinguished among different cell lines, it is very difficult to distinguish in clinical practice. The aim of the current study was to use the gene expression analysis from breast cancer cell lines to predict clinical outcomes of patients with breast cancer...
September 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944916/total-glucosides-of-paeony-ameliorates-tnbs%C3%A2-induced-colitis-by-modulating-differentiation-of-th17-treg-cells-and-the-secretion-of-cytokines
#10
Haihua Lin, Wenyou Zhang, Xuepei Jiang, Renpin Chen, Xielin Huang, Zhiming Huang
The imbalance between effector CD4+ T helper 17 (Th17) and regulatory CD4+ T cells (Treg) cells and their associated cytokines, have been associated with the pathogenesis of inflammatory bowel disease (IBD). Total glycosides of paeony (TGP) is an alternative immunomodulatory agent that is widely used for the treatment of autoimmune diseases. The present study aimed to evaluate the modulatory effect of TGP in a rat model of colitis induced by 2,4,6‑trinitrobenzene sulfonic acid (TNBS). TGP was administered intragastrically 24 h after the TNBS intrarectal instillation for 7 days...
September 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944902/rna%C3%A2-sequence-analysis-of-samples-from-patients-with-idiopathic-adhesive-capsulitis
#11
Jiaming Cui, Tongda Zhang, Jianyi Xiong, Wei Lu, Li Duan, Weimin Zhu, Daping Wang
The present study aimed to investigate idiopathic adhesive capsulitis (frozen shoulder), to gain insights on its pathogenesis, diagnosis and therapeutic targets. Using RNA‑sequencing (seq), the present study investigated differentially expressed genes (DEGs) in five samples from five idiopathic adhesive capsulitis patients and two samples from two acromioclavicular dislocation patients, without idiopathic adhesive capsulitis. The DEGs were analyzed using the following tools: Gene Ontology enrichment analysis, Kyoto Encyclopedia of Genes and Genomes pathways analysis and protein‑protein interaction analysis...
September 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944891/thioredoxin-is-implicated-in-the-anti%C3%A2-apoptotic-effects-of-grape-seed-proanthocyanidin-extract-during-hyperglycemia
#12
Xiang Ren, Heyuan Lu, Nina Wang, Chenghong Zhang, Yunpeng Ji, Shiqi Cui, Yichen Dong, Kaiyuan Yang, Mengyi Du, Fengsheng Diao, Li Kong
Diabetic retinopathy has long been recognized as a microvascular disease, however, recent research has indicated that diabetic retinopathy may also be considered a neurodegenerative disease. The elucidation of the molecular mechanisms underlying the development of diabetic retinopathy is imperative for the development of preventive and treatment strategies for patients with diabetes. In the present study, grape seed proanthocyanidin extract (GSPE) was used to upregulate the expression of thioredoxin (Trx), in order to evaluate its potential as a novel agent for the prevention and treatment of neurodegenerative diseases, including diabetic retinopathy...
September 18, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944877/sparcl1-suppresses-cell-migration-and-invasion-in-renal-cell-carcinoma
#13
Hui Ye, Wei-Gang Wang, Jun Cao, Xi-Chun Hu
Previous studies have shown that the human SPARC‑like 1 (SPARCL1) is crucial for human cancer migration and invasion. In the present study, the expression, biological function and possible molecular regulatory mechanisms of SPARCL1 were investigated in human renal cell carcinoma (RCC). The protein expression of SPARCL1 in cells was evaluated using western blot analysis and immunohistochemical staining in the tissue microarray. The effects of SPARCL1 on the biological behaviors of RCC cells were assessed using in vitro assays...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944850/differentially-expressed-long-non%C3%A2-coding-rnas-and-mrnas-in-patients-with-iga-nephropathy
#14
Nan Zuo, Yun Li, Nan Liu, Lining Wang
Long non‑coding RNAs (lncRNAs) have been reported to serve a crucial role in renal diseases; however, their role in immunoglobulin A nephropathy (IgAN) remains unclear. In the present study, peripheral blood mononuclear cells (PBMCs) were collected from both patients with IgAN and healthy controls. A microarray analysis was then performed to identify differentially expressed lncRNAs and mRNAs in PBMCs, which were confirmed by quantitative polymerase chain reaction. In addition, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and lncRNA‑mRNA co‑expression network analyses were conducted...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944845/efficient-inhibition-of-duck-hepatitis-b-virus-dna-by-the-crispr-cas9-system
#15
Qingfen Zheng, Li Bai, Sujun Zheng, Mei Liu, Jinyan Zhang, Ting Wang, Zhongwei Xu, Yu Chen, Jiansheng Li, Zhongping Duan
Current therapeutic strategies cannot eradicate hepatitis B virus covalently closed circular DNA (HBV cccDNA), which accounts for the persistence of HBV infection. Very recently, the clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR‑associated protein 9 (Cas9) system has been used as an efficient and powerful tool for viral genome editing. Given that the primary duck hepatocyte (PDH) infected with duck hepatitis B virus (DHBV) has been widely used to study human HBV infection in vitro, the present study aimed to demonstrate the targeted inhibition of DHBV DNA, especially cccDNA, by the CRISPR/Cas9 system using this model...
September 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944824/efficient-gene-therapy-with-a-combination-of-ultrasound%C3%A2-targeted-microbubble-destruction-and-pei-dna-nls-complexes
#16
Yi-Jia Wang, Qing Zhou, Sheng Cao, Bo Hu, Qing Deng, Nan Jiang, Jingjing Cui
Current strategies of gene transfection are not efficient at achieving a notable therapeutic effect. The aim of the present study was to combine ultrasound‑targeted microbubble destruction (UTMD) with a polyethylenimine/pEGFP‑N3 plasmid/nuclear localization sequence (PEI/DNA/NLS) complex gene delivery system, and evaluate the transfection efficiency of enhanced green fluorescent protein (EGFP) gene delivery to 293T cells using this system. The formation of PEI/DNA/NLS complexes and the protective effects of PEI/NLS were verified by gel electrophoresis...
September 18, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944823/integrated-strategy-of-differentially-expressed-genes-associated-with-ulcerative-colitis
#17
Juerong Feng, Qian Gao, Qing Liu, Fan Wang, Xue Lin, Qiu Zhao, Jing Liu, Jin Li
Ulcerative colitis (UC) is a chronic inflammatory bowel disease that is associated with both genetic and environmental factors; however, the underlying pathogenesis of UC remains unclear. The present study aimed to further explore 12 microarray datasets from patients with UC obtained from the Gene Expression Omnibus repository, for potential genetic pathogenesis of UC through a global bioinformatics view, which included identification of differentially expressed genes (DEGs), functional enrichments, protein‑protein interactions, transcriptional and post‑transcriptional regulation and drug‑gene associations...
September 18, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944817/recent-advances-in-the-synthesis-of-functional-materials-by-engineered-and-recombinant-living-cells
#18
Malte Winnacker
At the interface of materials science and synthetic biology, several concepts were recently developed for the production of functional materials by living cells. Selected recent strategies for this are highlighted here with a focus on bioactive, electronic and fluorescent materials.
September 25, 2017: Soft Matter
https://www.readbyqxmd.com/read/28944815/chemical-mediated-elasto-capillarity-of-elastic-sheets
#19
Jianlin Liu, Yulong Gong, Gaofeng Cao
Capillary forces can cause outstanding deformation of slender structures, and this behavior holds great potential in a plethora of areas. In this study, we propose a facile strategy to mediate the deformation of elastic structures via chemicals, which is named chemo-elasto-capillarity. The experiment shows that the added surfactant can significantly change the interfacial energy of the system, and then modulate the configuration of the adhered structures. The wetted length and deflection of each sheet can be predicted using the large and infinitesimal deformation theory of beams, and these theoretical values are in excellent agreement with the experimental results...
September 25, 2017: Soft Matter
https://www.readbyqxmd.com/read/28944812/spin-state-correlated-optical-properties-of-copper-ii-nitroxide-based-molecular-magnets
#20
Irina Yu Barskaya, Sergey L Veber, Elizaveta A Suturina, Peter S Sherin, Kseniya Yu Maryunina, Natalia A Artiukhova, Evgeny V Tretyakov, Renad Z Sagdeev, Victor I Ovcharenko, Nina P Gritsan, Matvey V Fedin
Molecular magnets based on copper(ii) ions and stable nitroxide radicals exhibit promising switchable behavior triggered by a number of external stimuli; however, their spin-state-correlated optical properties vital for photoinduced switching have not been profoundly investigated to date. Herein, the electronic absorption spectra of single crystals of three representatives of this unique family are studied experimentally and theoretically in the visible and near-IR regions. We established that the color of the complexes is mainly determined by optical properties of the nitroxide radicals, whereas the Cu(hfac)2 fragment contributes to the near-IR range with the intensity smaller by an order of magnitude...
September 25, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
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