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Fresh frozen plasma dosage

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https://www.readbyqxmd.com/read/26722660/perioperative-effects-of-high-doses-of-intraoperative-thymoglobulin-induction-in-liver-transplantation
#1
Lesley De Pietri, Valentina Serra, Giuseppe Preziosi, Gianluca Rompianesi, Bruno Begliomini
AIM: To describe our single-centre experience in liver transplantation (LT) with the infusion of high perioperative thymoglobulin doses. The optimal dosage and timing of thymoglobulin(®) [antithymocyte globulin (ATG)] administration during LT remains controversial. Cytokine release syndrome, haemolytic anaemia, thrombocytopenia, neutropenia, fever and serum sickness are potential adverse effects associated with ATG infusion. METHODS: Between December 2009 and December 2010, 16 adult non-randomized patients (ATG group), receiving a liver graft from a deceased donor, received an intraoperative infusion (4-6 h infusion) of thymoglobulin (3 mg/kg, ATG: Thymoglobuline(®))...
December 24, 2015: World Journal of Transplantation
https://www.readbyqxmd.com/read/26599105/desmopressin-acetate-as-a-haemostatic-elevator-in-individuals-with-combined-deficiency-of-factors-v-and-viii-a-clinical-trial
#2
H Mansouritorghabeh, A Shirdel
UNLABELLED: ESSENTIALS: Combined factor V (FV) and factor VIII (FVIII) deficiency (CF5F8D) is an autosomal recessive coagulation disorder. Desmopressin acetate (DDAVP) was intravenously infused in 20 adult patients with CF5F8D. DDAVP can enhance FVIII levels but has no effect on FV levels in patients with CF5F8D. DDAVP can be substituted for FVIII concentrates in patients with CF5F8D. OBJECTIVES: Combined factor V (FV) and FVIII deficiency (CF5F8D) is a rare inherited autosomal recessive double-gene disorder most frequently seen in the Middle East...
February 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/26330876/comparison-between-prothrombin-complex-concentrate-pcc-and-fresh-frozen-plasma-ffp-for-the-urgent-reversal-of-warfarin-in-patients-with-mechanical-heart-valves-in-a-tertiary-care-cardiac-center
#3
Bahram Fariborz Farsad, Reza Golpira, Hamideh Najafi, Ziae Totonchi, Shirin Salajegheh, Hooman Bakhshandeh, Farshad Hashemian
Fresh frozen plasma (FFP) and prothrombin complex concentrate (PCC) reverse oral anticoagulants such as Warfarin. We compared the standard dosage of FFP and PCC in terms of efficacy and safety for patients with mechanical heart valves undergoing interventional procedures while receiving Warfarin. Fifty patients were randomized (25 for each group) with mechanical heart valves [international normalized ratio (INR) >2.5]. FFP dosage was administered based on body weight (10-15 mL/Kg), while PCC dosage was administered based on both body weight and target INR...
2015: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/26309583/investigation-of-the-current-situation-of-massive-blood-transfusion-in-different-surgical-departments-a-large-multicenter-study-in-china
#4
Yang Sun, Zhan-Kui Jin, Cui-Xiang Xu, Qian-Li Dang, Li-Jie Zhang, Hong-Nan Chen, Yao-Jun Song, Jiang-Cun Yang
OBJECTIVE: This study aims to learn about the current situation of surgical massive blood transfusion of different surgical departments in China's Tertiary hospitals, which could provide the basis for the formulation of guidelines on massive blood transfusion. METHOD: A multicenter retrospective research on the application status of blood constituents during massive blood transfusion was conducted and a comparative analyses of survival and length of hospitalization in patients from different departments (trauma, cardiac surgery, obstetric conditions, or other common surgeries), were performed...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/26193715/-damage-control-resuscitation-of-severe-multiple-trauma-in-the-pelvic-fractures
#5
Chang-guo Fu
OBJECTIVE: To discuss the clinical effects of damage control resuscitation (DCR) in treating severe multiple trauma in the pelvic fractures. METHODS: From March 2009 to September 2013, a restrospective analysis was conducted on the clinical data of 28 patients with multiple trauma in the pelvic fractures, including 19 males and 9 females, ranging in age from 21 to 51 years old with an average of 32.5 years old. According to Tile classification of pelvic fractures, 16 cases were type B and 12 cases were type C...
May 2015: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/25785095/the-plasma-and-platelet-are-important-in-reducing-the-mortality-in-surgical-massive-blood-transfusion-a-large-multicenter-study-in-china
#6
Zhan-Kui Jin, Yang Sun, Qian-Li Dang, Li-Jie Zhang, Ling Li, Yong-Gang Xu, Hong-Nan Chen, Cui-Xiang Xu, Yao-Jun Song, Jiang-Cun Yang
OBJECTIVE: The aim of this study was to learn the current situation of surgical massive transfusion of death and survival groups in China, which could provide the basis for the formulation of guidelines on massive transfusion. METHODS: A multicenter retrospective research for the application status of blood constituents during massive blood transfusion was conducted, the differences of fresh frozen plasma and platelet application between death group and survival group were compared, and the transfusion volume and the distribution of other blood constituents were analyses at different periods of time when red blood cells are infused between death group and survival group...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/25338526/haemostatic-alterations-induced-by-treatment-with-asparaginases-and-clinical-consequences
#7
Valerio De Stefano, Tommaso Za, Angela Ciminello, Silvia Betti, Elena Rossi
The benefit of asparaginase for treating acute lymphoid leukaemia (ALL) has been well established. Native asparaginase derives from Escherichia coli (colaspase) or Erwinia chrysanthemi (crisantaspase); in a third preparation, colaspase is pegylated. Depletion of asparagine leads to decreased synthesis of procoagulant, anticoagulant, and fibrinolytic proteins, with resultant hypercoagulability and greater risk of venous thromboembolism (VTE). Colaspase and crisantaspase are not dose-equivalent, with crisantaspase displaying haemostatic toxicity only at dosages much higher and administered more frequently than those of colaspase...
February 2015: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/25241475/-clinical-observation-of-damage-control-resuscitation-in-rescue-multiple-fracture-with-hemorrhagic-shock
#8
Chang-Guo Fu
OBJECTIVE: To investigate clinical effects of damage contral resuscitation (DCR) in rescue multiple fracture with hemorrhagic shock. METHODS: From January 2009 to May 2013, clinical data of 24 patients suffered from multiple fracture with hemorrhagic shock were retrospectively reviewed. Among them, 18 cases were male and 6 cases were female, aged from 21 to 48 years old with an average of (32.5 +/- 4.5). Small capacity of balanced salt solution were used to maintain systolic, pressure (80-90) mmHg before operation...
June 2014: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/25126179/application-status-of-blood-constituents-during-massive-blood-transfusion-in-some-regions-of-china
#9
Jiang-Cun Yang, Yang Sun, Cui-Xiang Xu, Qian-Li Dang, Ling Li, Yong-Gang Xu, Yao-Jun Song, Hong Yan
OBJECTIVE: This study aims to learn about the current situation of surgical massive blood transfusion in China's Class III general hospitals, which could provide the basis for the formulation of guidelines on massive blood transfusion. METHODS: A multicenter retrospective research on the application status of blood constituents during massive blood transfusion was conducted and a comparative analysis on the distribution of the population infused with other blood constituents and the transfusion volume at different periods of time when red blood cells are infused in different units within 24 hours as well as on the blood applied for both the death group and survival group was made in this study...
2014: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/24860124/evidence-based-use-of-ffp-the-influence-of-a-priming-strategy-without-ffp-during-cpb-on-postoperative-coagulation-and-recovery-in-pediatric-patients
#10
RANDOMIZED CONTROLLED TRIAL
X Miao, J Liu, M Zhao, Y Cui, Z Feng, J Zhao, C Long, S Li, F Yan, X Wang, S Hu
OBJECTIVE: Although fresh frozen plasma (FFP) is one of the most commonly used hemostatic agents in clinical specialties today, there is little evidence available supporting its administration. Our present study observed the effects of a priming strategy without FFP during cardiopulmonary bypass (CPB) on postoperative coagulation and clinical recovery in pediatric patients, aiming to supply new evidence for evidence-based use of FFP. METHOD: Eighty pediatric patients with congenital heart disease undergoing cardiac surgery with CPB were randomized to receive either 10-20 ml/kg 4% succinylated gelatin (Gelofusine, GEL group, n = 40) or 1-2 units FFP (FFP group, n = 40) in the pump prime...
March 2015: Perfusion
https://www.readbyqxmd.com/read/24781251/evaluation-of-a-fixed-weight-based-dose-of-3-factor-prothrombin-complex-concentrate-without-adjunctive-plasma-following-warfarin-associated-intracranial-hemorrhage
#11
Kerry M Mohrien, G Morgan Jones, Andrew B Boucher, Lucas Elijovich
INTRODUCTION: Data regarding use of prothrombin complex concentrate (PCC) for international normalization ratio (INR) reversal in warfarin-associated intracranial hemorrhage (wICH) is variable with regards to dosages, adjunctive agents, and product choice. In 2012, we implemented a fixed, weight-based [30 IU/kg] dosing protocol of 3-factor PCC (3PCC) utilizing a rapid infusion rate and no requirement for fresh frozen plasma (FFP) following factor product administration. We aimed to evaluate the impact of this protocol on immediate and delayed INR reversal in patients admitted with wICH in the absence of FFP co-administration...
August 2014: Neurocritical Care
https://www.readbyqxmd.com/read/24612427/management-of-orthopaedic-surgery-in-rare-bleeding-disorders
#12
S M Siboni, E Biguzzi, G Pasta, P M Mannucci, C Mistretta, N N Fantini, L P Solimeno, F Peyvandi
Knowledge regarding the management of orthopaedic surgery in patients with rare bleeding disorders (RBDs) is limited. Retrospective data collection and analysis of 35 orthopaedic procedures (6 minor and 29 major) carried out in 22 patients with RBD between 1982 and 2013. These surgeries were performed using heterogeneous regimens of hemostatic therapy, except for seven procedures performed with no hemostatic treatment in four patients with mild factor deficiency. Of the 28 procedures carried out with hemostatic treatment, nine (32%) were performed using replacement therapy with dosages of concentrates of the deficient factor aimed to achieve perioperative plasma levels judged to be compatible with hemostasis; three (11%) using factor replacement therapy associated with fresh frozen plasma (FFP); four (14%) using recombinant activated factor VII; four (14%) using virus inactivated plasma alone; three (11%) using virus inactivated plasma associated with desmopressin; one (4%) using FFP alone; and four (14%) procedures using tranexamic acid alone...
September 2014: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/24426326/an-audit-of-management-of-patients-on-oral-anticoagulant-therapy-with-international-normalized-ratio-inr-five-or-above
#13
Sandeep Chopra, Naveen Kakkar
Maintaining the international normalized ratio (INR) within the therapeutic range in patients on oral anticoagulant treatment is a challenge for the physician. Excessive anticoagulation poses the risk of bleeding in patients. Management strategies vary among clinicians although standard guidelines exist for the same. We conducted an audit in patients on oral anticoagulant therapy in our hospital with excessive anticoagulation. This retrospective study was carried out among patients on oral anticoagulant therapy for various thrombotic conditions with at least a single INR recording of 5 or more...
March 2013: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/24398441/high-dose-fibrinogen-versus-a-clinically-recommended-dose-of-fresh-frozen-plasma-for-reversal-of-dilutional-coagulopathy-in-an-in-vitro-model-of-severe-hemodilution
#14
COMPARATIVE STUDY
C Rosenthal, J Rau, T Volk, M Sander, S Ziemer, C Von Heymann
BACKGROUND: Volume substitution using colloids and crystalloids dose-dependently induces dilutional coagulopathy. For treatment, fibrinogen concentrate and fresh frozen plasma are options, though the effective dosage of either agent is unclear. The objective of this study was to evaluate, whether high-dose fibrinogen or recommended doses of fresh frozen plasma are equally effective in reversing profound dilutional coagulopathy in vitro. METHODS: Blood samples of ten healthy volunteers were diluted by 60% with normal saline, balanced 4% gelatin, or balanced 6% hydroxyethyl starch 130/0...
August 2014: Minerva Anestesiologica
https://www.readbyqxmd.com/read/24338807/optimizing-the-dose-of-three-factor-prothrombin-complex-concentrate-in-traumatic-brain-injury-patients-on-warfarin-therapy
#15
Thao K Huynh, Jennifer L Costello, Jill A Rebuck
STUDY OBJECTIVE: To determine the percentage of patients with correction of their first international normalized ratio (INR) less than 1.5 after administration of moderate-dose three-factor prothrombin complex concentrate (PCC), 35 IU/kg compared with low-dose PCC, 25 IU/kg. DESIGN: Retrospective review. SETTING: Community teaching hospital. PATIENTS: A total of 42 adult patients diagnosed with warfarin-associated traumatic brain injury (TBI) presented with an INR of 1...
March 2014: Pharmacotherapy
https://www.readbyqxmd.com/read/24160257/the-identification-of-a-novel-splicing-mutation-in-c1qb-in-a-japanese-family-with-c1q-deficiency-a-case-report
#16
Yousuke Higuchi, Junya Shimizu, Michiyo Hatanaka, Etsuko Kitano, Hajime Kitamura, Hidetoshi Takada, Masataka Ishimura, Toshiro Hara, Osamu Ohara, Kenji Asagoe, Toshihide Kubo
C1q deficiency is a rare disease that is associated with a high probability of developing systemic lupus erythematosus. We report a 4-year-old Japanese girl who presented with fever, facial erythema, joint pain, and oral ulceration. Complement deficiencies were suspected because of her persistent hypocomplementemia and normal levels of the complement proteins C3 and C4. We identified a novel homozygous splicing mutation in the C1qB gene, c.187 + 1G > T, which is the first mutation to be confirmed in a Japanese individual...
October 28, 2013: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/23547902/drastic-reduction-of-piperacillin-tazobactam-concentrations-in-an-in-vitro-model-of-continuous-venovenous-hemofiltration-proposal-of-an-innovative-modality-of-administration-to-maintain-them-at-constant-concentration
#17
Michele Ferrannini, Pasquale Niscola, Clorinda Falcone, Annalisa Noce, Anna Pastore, Gianna Di Giovamberardino, Andrea Tendas, Laura Scaramucci, Nicola Di Daniele, Roberto Palumbo
BACKGROUND/AIMS: Critically-ill patients often undergo continuous renal replacement therapy (CRRT) and need antimicrobial therapy. Piperacillin and tazobactam (Pip-Tzb) are cleared by CRRT. Our aim is to evaluate Pip-Tzb removal in an in-vitro-single-pool-model of continuous-veno-venous-hemofiltration (CVVH); we test a new method of Pip-Tzb administration during CRRT assuring constant levels of concentrations above the minimum inhibitory concentration (MIC). METHODS: In an in-vitro-single-pool-model of CVVH, two solutions (Protein-Free-Solution, PFS and Fresh-Frozen- Plasma, FFP) added with Pip-Tzb were tested for Pip-Tzb removal and adsorption...
September 2013: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/23174035/assessment-of-the-thrombin-generation-assay-in-haemophilia-comparative-study-between-fresh-and-frozen-platelet-rich-plasma
#18
V Vila, J A Aznar, A Moret, A Marco, S Navarro, C Vila, F España
The severity of haemophilia A has traditionally been classified by the dosage of factor VIII (FVIII) by one-step coagulation tests. However, an homogeneous group of patients with similar FVIII levels show clinical heterogeneity and 10-15% of the patients classified as severe haemophilia do not have a severe bleeding phenotype. Traditional tests used for measuring FVIII are not capable of detecting other prohaemorrhagic or prothrombotic factors. Global tests as the thrombin generation assay (TGA) may detect these haemostatic factors...
March 2013: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/23152198/prophylactic-administration-of-prothrombin-complex-concentrates-for-congenital-prothrombin-deficiency-with-a-novel-frameshift-mutation-prothrombin-saitama
#19
Masafumi Seki, Katsuyoshi Koh, Takeshi Inoue, Yuzo Tomita, Motohiro Kato, Masaki Shimizu, Eriko Morishita, Ryoji Hanada
Prothrombin (Factor II, FII) deficiency is an extremely rare autosomal recessive condition with an estimated incidence of 1:2 million. As severe and life-threatening bleeding is rare in FII deficiency, on demand therapy with administration of prothrombin complex concentrates (PCCs) or fresh frozen plasma is generally performed, and prophylactic therapy for FII deficiency has been reported in only three cases. Thus, its optimal dosage and schedule has remained uncertain. Here we report a case of severe prothrombin deficiency with a novel frameshift mutation of the F2 gene, who was started on prophylactic administration...
March 2013: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/23123988/drug-devices-technologies-and-techniques-for-blood-management-in-minimally-invasive-and-conventional-cardiothoracic-surgery-a-consensus-statement-from-the-international-society-for-minimally-invasive-cardiothoracic-surgery-ismics-2011
#20
Alan H Menkis, Janet Martin, Davy C H Cheng, David C Fitzgerald, John J Freedman, Changqing Gao, Andreas Koster, G Scott Mackenzie, Gavin J Murphy, Bruce Spiess, Niv Ad
OBJECTIVE: The objectives of this consensus conference were to evaluate the evidence for the efficacy and safety of perioperative drugs, technologies, and techniques in reducing allogeneic blood transfusion for adults undergoing cardiac surgery and to develop evidence-based recommendations for comprehensive perioperative blood management in cardiac surgery, with emphasis on minimally invasive cardiac surgery. METHODS: The consensus panel short-listed the potential topics for review from a comprehensive list of potential drugs, devices, technologies, and techniques...
July 2012: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
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