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https://www.readbyqxmd.com/read/29773756/mir126-5p-down-regulation-facilitates-axon-degeneration-and-nmj-disruption-via-a-non-cell-autonomous-mechanism-in-als
#1
Roy Maimon, Ariel Ionescu, Avichai Bonnie, Sahar Sweetat, Shane Wald-Altman, Shani Inbar, Tal Gradus, Davide Trotti, Miguel Weil, Oded Behar, Eran Perlson
Axon degeneration and disruption of neuromuscular junctions (NMJs) are key events in Amyotrophic Lateral Sclerosis (ALS) pathology. Although the disease's etiology is not fully understood, it is thought to involve a non-cell-autonomous mechanism and alterations in RNA metabolism. Here, we identified reduced levels of miR-126-5p in pre-symptomatic ALS male mice models, and an increase in its targets: axon destabilizing type-3 Semaphorins and their co-receptor Neuropilins. Utilizing compartmentalized in vitro co-cultures, we demonstrated that myocytes expressing diverse ALS-causing mutations promote axon degeneration and NMJ dysfunction, which were inhibited by applying Neuropilin1 (NRP1) blocking antibody...
May 17, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29766503/transcriptome-analysis-of-potential-mirna-involved-in-adipogenic-differentiation-of-c2c12-myoblasts
#2
Ye Hou, Liangliang Fu, Jingjin Li, Jingxuan Li, Yunxia Zhao, Yu Luan, An Liu, Huiying Liu, Xinyun Li, Shuhong Zhao, Changchun Li
>Emerging evidence indicates that microRNA (miRNA) plays an important role in adipogenesis and disease pathogenesis. To investigate the miRNA involved in regulating different periods of adipogenesis, we performed a comprehensive study on microRNAome during the stimulation of adipogenesis by an adipogenic differentiation cocktail in C2C12 myoblasts at 0, 2, 4, and 7 days using the Solexa sequencing technology. In this study, we identified 52 differentially expressed (DE) miRNA. Functional annotation indicated that the target genes of DE miRNA were mostly enriched in adipogenic transdifferentiation and fat metabolism-related pathways, including Wnt, mitogen-activated protein kinase (MAPK), and insulin signaling...
May 16, 2018: Lipids
https://www.readbyqxmd.com/read/29762824/long-noncoding-rna-uca1-promotes-cell-proliferation-migration-and-invasion-of-human-leukemia-cells-via-sponging-mir-126
#3
M-D Sun, Y-Q Zheng, L-P Wang, H-T Zhao, S Yang
OBJECTIVE: Acute myeloid leukemia (AML) is a bone marrow malignancy. Long non-coding RNA (lncRNA) urothelial carcinoma-associated 1 (UCA1) plays an important role in several cancers. However, the role of lncRNA UCA1 in AML remained unclear. MATERIALS AND METHODS: LncRNA UCA1 expressions in different cell lines were determined by RT-PCR. In human myelogenous leukemia (ML) cell lines K562 and HL60, effects of lncRNA UCA1 knockdown on cell viability, migration, invasion, and apoptosis were assessed, respectively...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29760722/microrna-126-priming-enhances-functions-of-endothelial-progenitor-cells-under-physiological-and-hypoxic-conditions-and-their-therapeutic-efficacy-in-cerebral-ischemic-damage
#4
Qunwen Pan, Jieyi Zheng, Donghui Du, Xiaorong Liao, Chunlian Ma, Yi Yang, Yanyu Chen, Wangtao Zhong, Xiaotang Ma
Endothelial progenitor cells (EPCs) have shown the potential for treating ischemic stroke (IS), while microRNA-126 (miR-126) is reported to have beneficial effects on endothelial function and angiogenesis. In this study, we investigated the effects of miR-126 overexpression on EPCs and explore the efficacy of miR-126-primed EPCs (EPCmiR-126 ) in treating IS. The effects of miR-126 overexpression on EPC proliferation, migratory, tube formation capacity, reactive oxygen species (ROS) production, and nitric oxide (NO) generation were determined...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29743819/involvement-of-mir-126-in-autoimmune-disorders
#5
REVIEW
Marco Casciaro, Eleonora Di Salvo, Teresa Brizzi, Carmelo Rodolico, Sebastiano Gangemi
Background: Micro-RNA represent a great family of small non-condign ribonucleic acid molecules; in particular microRNA-126 is an important member of this family and is expressed in many human cells such as cardiomyocytes, endothelial and lung cells. Some studies have shown the implication of miR-126 in cancer, but recently significant progresses have also been made in determining the role of miR-126 regulating immune-related diseases; probably, in a near future, they could potentially serve as diagnostic biomarkers or therapeutic targets...
2018: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/29728572/identification-of-mirnas-in-cervical-mucus-as-a-novel-diagnostic-marker-for-cervical-neoplasia
#6
Satoshi Kawai, Takuma Fujii, Iwao Kukimoto, Hiroya Yamada, Naoki Yamamoto, Makoto Kuroda, Sayaka Otani, Ryoko Ichikawa, Eiji Nishio, Yutaka Torii, Aya Iwata
microRNAs (miRNAs) play important roles in regulation of gene expression during cervical carcinogenesis. We investigated expression profiles of miRNAs in cervical cancer and its precursor lesions by utilizing cervical mucus. Cervical mucus was collected from 230 patients with a normal cervix, cervical intraepithelial neoplasia (CIN), squamous cell carcinoma (SCC), or adenocarcinoma (AD). The levels of miRNA in the mucus were quantified by miRNA array and real-time reverse-transcriptase polymerase chain reaction (RT-PCR)...
May 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29725463/quantitative-assessment-of-gene-promoter-methylation-in-non-small-cell-lung-cancer-using-methylation-sensitive-high-resolution-melting
#7
Fangming Liu, Honglian Zhang, Shaohua Lu, Zhenhua Wu, Lin Zhou, Zule Cheng, Yanan Bai, Jianlong Zhao, Qiqing Zhang, Hongju Mao
DNA methylation is closely associated with aberrant epigenetic changes. Previous studies have identified various genes associated with non-small cell lung cancer (NSCLC), but the precise combination responsible for its etiology is still debated. The aim of the present study was to select a new set of NSCLC-related genes using methylation-sensitive high-resolution melting. The promoter methylation status of six selected genes, consisting of protocadherin γ subfamily B, 6 (PCDHGB6), homeobox A9 (HOXA9), O6 -methylguanine-DNA methyltransferase (MGMT), microRNA (miR)-126, suppressor of cytokine signaling 3 (SOCS3) and Ras association domain family member 5, also termed NORE1A, was evaluated in 54 NSCLC patients...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29725450/mir-126-suppresses-epithelial-to-mesenchymal-transition-and-metastasis-by-targeting-pi3k-akt-snail-signaling-of-lung-cancer-cells
#8
Zhijun Jia, Ying Zhang, Qinfeng Xu, Wanhua Guo, Aibin Guo
Although previous studies have demonstrated that dysregulation of microRNA (miR)-126 is associated with the progression of several types of cancer, including lung cancer, the relationship between miR-126 and lung cancer metastasis remains unclear. SPC-A1 lung cancer cells were transfected with miR-126 mimic and negative control using Lipofectamine® 3000. Following 2 h, TGF-β1 was used to induce epithelial-to-mesenchymal transition (EMT). The protein expression levels of EMT markers: E-cadherin, fibronectin, N-cadherin and vimentin were detected by western blot analysis or immunofluorescence staining...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29710530/resveratrol-improves-uric-acid-induced-pancreatic-%C3%AE-cells-injury-and-dysfunction-through-regulation-of-mir-126
#9
Ying Xin, Haiyan Zhang, Zhaotong Jia, Xiaoqian Ding, Yong Sun, Qiang Wang, Tao Xu
Resveratrol (RSV) has been reported to exert anti-inflammatory, anti-oxidant and anti-cancer effects both in vivo and in vitro, and is widely used to treat various diseases. However, the effect of RSV on type 2 diabetes (T2D) is still unclear. The present study aimed to explore the effect of RSV on UA-induced cell injury and dysfunction in pancreatic β-cells. The mouse insulinoma cell line Min6 was treated with 5 mg/dl UA and different concentrations of RSV. Then, cell viability, apoptosis, apoptosis-associated factors, iNOS expression and insulin secretion were examined by CCK-8, flow cytometry, western blot, qRT-PCR and glucose-stimulated insulin secretion (GSIS), respectively...
June 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29707110/characterization-of-mirna-and-their-target-gene-during-chicken-embryo-skeletal-muscle-development
#10
Endashaw Jebessa, Hongjia Ouyang, Bahareldin Ali Abdalla, Zhenhui Li, Auwalu Yusuf Abdullahi, Qingshen Liu, Qinghua Nie, Xiquan Zhang
MicroRNAs (miRNAs) are non-coding RNAs that regulate mRNA expression by degradation or translational inhibition. We investigated the underlying molecular mechanisms of skeletal muscle development based on differentially expressed genes and miRNAs. We compared mRNA and miRNA from chicken skeletal muscle at embryonic day E11, E16 and one day post-hatch (P1). The interaction networks were constructed, according to target prediction results and integration analysis of up-regulated genes with down regulated miRNAs or down-regulated genes with up-regulated miRNAs with |log2fold change| ≥ 1...
April 3, 2018: Oncotarget
https://www.readbyqxmd.com/read/29695253/microrna-expression-profiling-for-the-prediction-of-resistance-to-neoadjuvant-radiochemotherapy-in-squamous-cell-carcinoma-of-the-esophagus
#11
Julia Slotta-Huspenina, Enken Drecoll, Marcus Feith, Daniel Habermehl, Stephanie Combs, Wilko Weichert, Marcus Bettstetter, Karen Becker, Rupert Langer
BACKGROUND: MicroRNAs (miRNAs) play an important role in cancer biology. Neoadjuvant radiochemotherapy followed by surgery is a standard treatment for locally advanced esophageal squamous cell carcinoma (ESCC). However, a subset of patients do not respond. We evaluated whether miRNA profiles can predict resistance to radiochemotherapy. METHODS: Formalin-fixed, paraffin-embedded pretherapeutic biopsies of patients treated by radiochemotherapy followed by esophagectomy were analyzed...
April 25, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29689545/urinary-and-blood-microrna-126-and-770-are-potential-noninvasive-biomarker-candidates-for-diabetic-nephropathy-a-meta-analysis
#12
Sungjin Park, SeongRyeol Moon, Kiyoung Lee, Ie Byung Park, Dae Ho Lee, Seungyoon Nam
BACKGROUND/AIMS: Diabetic nephropathy (DN), a major diabetic microvascular complication, has a long and growing list of biomarkers, including microRNA biomarkers, which have not been consistent across preclinical and clinical studies. This meta-analysis aims to identify significant blood- and urine-incident microRNAs as diagnostic/prognostic biomarker candidates for DN. METHODS: PubMed, Web of Science, and Cochrane Library were searched from their earliest records through 12th Dec 2016...
April 18, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29685146/pretreatment-microrna-levels-can-predict-hbsag-clearance-in-chb-patients-treated-with-pegylated-interferon-%C3%AE-2a
#13
Yanlin Yang, Ming Liu, Ying Deng, Yan Guo, Xuqing Zhang, Dedong Xiang, Li Jiang, Zhonglan You, Yi Wu, Maoshi Li, Qing Mao
BACKGROUND: To investigate the predictive capability of microRNAs (miRNAs) prior treatment for HBsAg clearance in chronic hepatitis B (CHB) treated with pegylated interferon α-2a (PEG-IFNα-2a). METHODS: The treatment effect was determined by HBsAg clearance and subjects were classified into HBsAg clearance group and non HBsAg clearance group. Differential miRNAs expression in peripheral blood mononuclear cells (PBMC) was screened using microarrays in an identification cohort (n = 20) and validated by quantitative reverse-transcription polymerase chain reaction (qRT-PCR) in a confirmation cohort (n = 47)...
April 23, 2018: Virology Journal
https://www.readbyqxmd.com/read/29674506/diagnostic-and-prognostic-roles-of-circulating-exosomal-micrornas-in-acquired-aplastic-anemia-and-myelodysplastic-syndromes
#14
Valentina Giudice, Lauren G Banaszak, Fernanda Gutierrez-Rodrigues, Sachiko Kajigaya, Reema Panjwani, Maria Del Pilar Fernandez Ibanez, Olga Rios, Christopher K Bleck, Erin S Stempinski, Diego Quinones Raffo, Danielle M Townsley, Neal S Young
Exosomal microRNAs modulate cancer cell metabolism and the immune response. Specific exosomal microRNAs have been reported to be reliable biomarkers of several solid and hematologic malignancies. We examined the possible diagnostic and prognostic values of exosomal microRNAs in two human bone marrow failure diseases, aplastic anemia and myelodysplastic syndromes. After screening of 372 microRNAs in a discovery set (n=42) of plasma exosome samples, we constructed a custom microRNA PCR plate, including 42 microRNAs, for validation in a larger cohort (n=99), and we identified 25 differentially expressed exosomal microRNAs uniquely or frequently present in aplastic anemia and/or myelodysplastic syndromes...
April 19, 2018: Haematologica
https://www.readbyqxmd.com/read/29642385/micrornas-as-potential-mediators-for-cigarette-smoking-induced-atherosclerosis
#15
Yuka Yokoyama, Nathan Mise, Yuka Suzuki, Saeko Tada-Oikawa, Kiyora Izuoka, Lingyi Zhang, Cai Zong, Akira Takai, Yoshiji Yamada, Sahoko Ichihara
Smoking increases the risk of atherosclerosis-related events, such as myocardial infarction and ischemic stroke. Recent studies have examined the expression levels of altered microRNAs (miRNAs) in various diseases. The profiles of tissue miRNAs can be potentially used in diagnosis or prognosis. However, there are limited studies on miRNAs following exposure to cigarette smoke (CS). The present study was designed to dissect the effects and cellular/molecular mechanisms of CS-induced atherosclerogenesis. Apolipoprotein E knockout (ApoE KO) mice were exposed to CS for five days a week for two months at low (two puffs/min for 40 min/day) or high dose (two puffs/min for 120 min/day)...
April 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29617185/long-non-coding-rna-metallothionein-1-pseudogene-3-promotes-p2y12-expression-by-sponging-mir-126-to-activate-platelet-in-diabetic-animal-model
#16
Ming Zhou, Meng Gao, Yanwei Luo, Rong Gui, Hongwen Ji
Platelet hyperaggregation and hypercoagulation are associated with increase of thrombogenic risk, especially in patients with type 2 diabetes (T2D). High activity of P2Y12 receptor is found in T2D patients, exposing such patients to a prothrombotic condition. P2Y12 is a promising target for antiplatelet, but due to P2Y12 receptor constitutive activation, the clinical practical phenomena such as "clopidogrel resistance" are commonly occurring. In this study, we investigate the role of lncRNA on platelet activation...
April 4, 2018: Platelets
https://www.readbyqxmd.com/read/29615970/the-potential-role-of-platelet-related-micrornas-in-the-development-of-cardiovascular-events-in-high-risk-populations-including-diabetic-patients-a-review
#17
REVIEW
Justyna Pordzik, Katarzyna Pisarz, Salvatore De Rosa, Axel Dyve Jones, Ceren Eyileten, Ciro Indolfi, Lukasz Malek, Marek Postula
Platelet activation plays a pivotal role in the development and progression of atherosclerosis, which often leads to potentially fatal ischemic events at later stages of the disease. Platelets and platelet microvesicles (PMVs) contain large amounts of microRNA (miRNA), which contributes largely to the pool of circulating miRNAs. Hence, they represent a promising option for the development of innovative diagnostic biomarkers, that can be specific for the underlying etiology. Circulating miRNAs can be responsible for intracellular communication and may have a biological effect on target cells...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29615793/association-between-hypertension-and-circulating-vascular-related-micrornas
#18
Jamie G Hijmans, Kyle J Diehl, Tyler D Bammert, Philip J Kavlich, Grace M Lincenberg, Jared J Greiner, Brian L Stauffer, Christopher A DeSouza
microRNAs (miRNAs) have a key role in regulating inflammation, vascular health and in turn, cardiovascular disease. Specifically, altered circulating expression of miR-17, miR-21, miR-34a, miR-92a, miR-126, miR-145, miR-146a, and miR-150 has been linked with the pathogenesis and progression of cardiovascular disease. The aim of this study was to determine whether the circulating profile of these vascular-related miRNAs is disrupted with hypertension. Thirty sedentary, middle-aged adults were studied: 15 normotensive (10M/5F; age: 56 ± 1 year; BP: 113/71 ± 2/1 mmHg) and 15 hypertensive (10M/5F; 56 ± 2 year; 140/87 ± 2/2 mmHg)...
April 4, 2018: Journal of Human Hypertension
https://www.readbyqxmd.com/read/29609545/relationship-of-cardiovascular-disease-risk-factors-and-noncoding-rnas-with-hypertension-a-case-control-study
#19
Shiying Chen, Rong Chen, Tingxing Zhang, Shaowei Lin, Zhou Chen, Bi Zhao, Huangyuan Li, Siying Wu
BACKGROUND: The present study sought to explore the relationship of common cardiovascular disease risk factors and noncoding RNAs with essential hypertension (EH). METHODS: A total of 402 EH patients and 402 gender- and age-frequency matched healthy controls were enrolled in this study. Each participant received a questionnaire survey, physical examination and laboratory tests. Quantitative real-time polymerase chain reaction (qPCR) was performed to assess relative expression levels of six noncoding RNAs (NR_027032, NR_034083, NR_104181, miR-126, miR-143 and miR-145) in peripheral blood leucocytes...
April 2, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29608698/circulating-pro-angiogenic-micro-ribonucleic-acid-in-patients-with-coronary-heart-disease
#20
Hualong Zhang, Jie Hao, Xinxin Sun, Youliang Zhang, Qingmin Wei
OBJECTIVES: Our goal was to evaluate the expressions of 14 selected pro-angiogenic micro-ribonucleic acids in patients with coronary heart disease (CHD) and healthy controls (HCs) and to assess the correlations of those micro-ribonucleic acids with risk and severity of CHD. METHODS: In the exploration stage, 20 patients with CHD were enrolled; in the validation stage, 102 patients with CHD and 92 age- and gender-matched HCs with the same eligibility of those in the exploration stage were recruited...
March 28, 2018: Interactive Cardiovascular and Thoracic Surgery
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