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https://www.readbyqxmd.com/read/29164588/lncrna-hoxa11-as-is-involved-in-fracture-healing-through-regulating-mir-124-3p
#1
X-N Wang, L-H Zhang, X-D Cui, M-X Wang, G-Y Zhang, P-L Yu
OBJECTIVE: Long noncoding RNAs (lncRNAs) have been reported to participate in many diseases. Fracture healing is one of these ordinary diseases. This study aims to identify how lncRNA HOXA11-AS affects the progression of fracture healing. MATERIALS AND METHODS: RT-qPCR was performed to detect the level of HOXA11-AS. Moreover, function assays including cell growth assay and cell apoptosis assay were performed to explore how HOXA11-AS functions in fracture healing...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29156804/hotair-regulates-hk2-expression-by-binding-endogenous-mir-125-and-mir-143-in-oesophageal-squamous-cell-carcinoma-progression
#2
Jian Ma, Yanxin Fan, Tingting Feng, Fangjun Chen, Zhipeng Xu, Suqing Li, Qingfeng Lin, Xiaoting He, Weihong Shi, Yang Liu, Xiufeng Cao, Bin Zhu, Zhihua Liu
Esophageal Squamous Cell Carcinoma (ESCC) is one of the most common malignant cancers worldwide with a high death rate worldwide. Long non-coding RNA (LncRNA) has been recently demonstrated to play a critical role in ESCC. LncRNA HOTAIR played important regulatory roles in ESCC. We highlight the molecular mechanisms by which HOTAIR could influence the expression of Hexokinase 2 (HK2) in ESCC through binding miR-125 and miR-143 directly. Taken together, this study identified a functional lncRNA HOTAIR involved with regulation of glycolysis via miRNA-125/miRNA-143-HK2 in ESCC cells...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156728/long-non-coding-rna-hotair-acts-as-a-competing-endogenous-rna-to-promote-malignant-melanoma-progression-by-sponging-mir-152-3p
#3
Wenkang Luan, Rubo Li, Liang Liu, Xin Ni, Yan Shi, Yun Xia, Jinlong Wang, Feng Lu, Bin Xu
HOX transcript antisense RNA (HOTAIR) is associated with the growth and metastasis of many human tumors, but its biological roles in malignant melanoma remain unclear. In this study, we show that HOTAIR is overexpressed in melanoma tissues and cells, especially in metastatic melanoma. High HOTAIR levels correlate with poor prognosis in melanoma patients. We also determined that HOTAIR functions as a competing endogenous RNA (ceRNA) for miR-152-3p. miR-152-3p was decreased and acted as a tumor suppressor in melanoma, and c-MET was the functional target of miR-152-3p...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29154942/levels-of-palmitic-acid-ester-of-hydroxystearic-acid-pahsa-are-reduced-in-the-breast-milk-of-obese-mothers
#4
Marie Brezinova, Ondrej Kuda, Jana Hansikova, Martina Rombaldova, Laurence Balas, Kristina Bardova, Thierry Durand, Martin Rossmeisl, Marcela Cerna, Zbynek Stranak, Jan Kopecky
To achieve optimal development of a newborn, breastfeeding is extensively recommended, but little is known about the role of non-nutritive bioactive milk components. We aimed to characterize the fatty acid esters of hydroxy fatty acids (FAHFAs), namely palmitic acid hydroxystearic acids (PAHSAs)-endogenous lipids with anti-inflammatory and anti-diabetic properties, in human breast milk. Breast milk samples from 30 lean (BMI=19-23) and 23 obese (BMI>30) women were collected 72h postpartum. Adipose tissue and milk samples were harvested from C57BL/6J mice...
November 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29152149/the-long-non-coding-rna-crnde-acts-as-a-cerna-and-promotes-glioma-malignancy-by-preventing-mir-136-5p-mediated-downregulation-of-bcl-2-and-wnt2
#5
Dong-Xue Li, Xiao-Rui Fei, Yong-Fei Dong, Chuan-Dong Cheng, Yang Yang, Xue-Fei Deng, Hai-Liang Huang, Wan-Xiang Niu, Chen-Xu Zhou, Cheng-Yu Xia, Chao-Shi Niu
The colorectal neoplasia differentially expressed (CRNDE) gene encodes a long non-coding RNA (lncRNA) that is the most unregulated among 129 lncRNAs differentially expressed in gliomas. In this study, we confirmed high CRNDE expression in clinical glioma specimens and observed through experiments in human glioma cell lines a novel molecular mechanism by which CRNDE may contribute to glioma pathogenesis. By inducing or silencing CRNDE expression, we detected a positive correlation between CRNDE levels and the proliferative, migratory, and invasive capacities of glioma cells, which were concomitant with a decreased apoptosis rate...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29149041/the-hmga1-pseudogene-7-induces-mir-483-and-mir-675-upregulation-by-activating-egr1-through-a-cerna-mechanism
#6
Marco De Martino, Giuseppe Palma, Amalia Azzariti, Claudio Arra, Alfredo Fusco, Francesco Esposito
Several studies have established that pseudogene mRNAs can work as competing endogenous RNAs and, when deregulated, play a key role in the onset of human neoplasias. Recently, we have isolated two HMGA1 pseudogenes, HMGA1P6 and HMGA1P7. These pseudogenes have a critical role in cancer progression, acting as micro RNA (miRNA) sponges for HMGA1 and other cancer-related genes. HMGA1 pseudogenes were found overexpressed in several human carcinomas, and their expression levels positively correlate with an advanced cancer stage and a poor prognosis...
November 17, 2017: Genes
https://www.readbyqxmd.com/read/29147064/lncrna-neat1-regulates-cell-viability-and-invasion-in-esophageal-squamous-cell-carcinoma-through-the-mir-129-ctbp2-axis
#7
Yong Li, Dong Chen, Xiang Gao, Xiaohui Li, Gongning Shi
Background: Long noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) was reported to be aberrantly upregulated and promote esophageal squamous cell carcinoma (ESCC) cell progression. Nevertheless, the molecular mechanism of NEAT1 involved in the competing endogenous RNA (ceRNA) regulatory network in ESCC progression remains poorly defined. Methods: The expressions of NEAT1, miR-129, and C-terminal-binding protein 2 (CTBP2) in ESCC cells were examined by qRT-PCR...
2017: Disease Markers
https://www.readbyqxmd.com/read/29146309/stard13-3-untranslated-region-functions-as-a-cerna-for-tp53inp1-in-prohibiting-migration-and-invasion-of-breast-cancer-cells-by-regulating-mir-125b-activity
#8
Lufeng Zheng, Xiaoman Li, Jinjiang Chou, Chenxi Xiang, Qianqian Guo, Zhiting Zhang, Xinwei Guo, Lanlan Gao, Yingying Xing, Tao Xi
Competitive endogenous messenger RNA (ceRNA) affects transcription of other RNA molecules by competitively binding common microRNAs. Previous studies have shown that TP53INP1 functions as a suppressor in tumor metastasis. Our study elucidated StarD13 messenger RNA as a ceRNA in regulating migration and invasion of breast cancer cells. MicroRNA-125b was identified to induce metastasis of MCF-7 cells and bind with both StarD13 3'UTR and TP53INP1 3'UTR. Therefore, a ceRNA interaction between StarD13 and TP53INP1 mediated by competitively binding to miR-125b was indicated...
November 11, 2017: European Journal of Cell Biology
https://www.readbyqxmd.com/read/29137975/microarray-analysis-of-an-synthetic-%C3%AE-synuclein-induced-cellular-model-reveals-the-expression-profile-of-long-non-coding-rna-in-parkinson-s-disease
#9
D Lin, Y Liang, X Jing, Y Chen, M Lei, Z Zeng, T Zhou, X Wu, S Peng, D Zheng, K Huang, L Yang, S Xiao, J Liu, E Tao
Long non-coding RNAs (lncRNAs) are a new research focus that are reported to influence the pathogenetic process of neurodegenerative disorders. To uncover new disease-associated genes and their relevant mechanisms, we carried out a gene microarray analysis based on a Parkinson's disease (PD) in vitro model induced by α-synuclein oligomers. This cellular model induced by 25 μmol/L α-synuclein oligomers has been confirmed to show the stable, transmissible neurotoxicity of α-synuclein, a typical PD pathological marker...
November 11, 2017: Brain Research
https://www.readbyqxmd.com/read/29131440/mir-193b-availability-is-antagonized-by-lncrna-snhg7-for-faim2-induced-tumour-progression-in-non-small-cell-lung-cancer
#10
Kelin She, Hui Yan, Jun Huang, Huaping Zhou, Jianxing He
OBJECTIVES: Long non-coding RNAs have identified to involve into the tumour cell proliferation, apoptosis and metastasis. We previously found that up-regulated LncRNA-SNHG7 (SNHG7) positively correlated to the Fas apoptosis inhibitory molecule 2 (FAIM2) in lung cancer cells with unclear mechanism. METHODS: Non-small cell lung cancer (NSCLC) and relative normal tissues (n = 25) were collected. The SNHG7 expression and function in NSCLC was determined. The SNHG7-miR 193b-FAIM2 network was analysed in vitro and vivo...
November 12, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/29130995/lncrna-uca1-promotes-mitochondrial-function-of-bladder-cancer-via-the-mir-195-arl2-signaling-pathway
#11
Hui-Jin Li, Xiao-Min Sun, Zheng-Kun Li, Qian-Wen Yin, Huan Pang, Jing-Jing Pan, Xu Li, Wei Chen
BACKGROUND/AIMS: This study aims to identify whether Urothelial Cancer Associated 1 (UCA1) regulates mitochondrial metabolic reprogramming in bladder cancer, and to explore how UCA1 participates in mitochondrial metabolism by the UCA1/miR-195/ARL2 signaling pathway; these findings may be aid in the development of tumor diagnostic and therapeutic strategies. METHODS: Bladder tissues were obtained from patients. Stable cell lines were constructed, with ectopic expression of UCA1 in UMUC2 cells and knockdown of UCA1 in 5637 cells...
November 1, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29130827/association-of-single-nucleotide-polymorphisms-in-immune-related-genes-with-development-of-dengue-hemorrhagic-fever-in-a-mexican-population
#12
Angélica Berenice Vargas-Castillo, Karina Ruiz-Tovar, Héctor Vivanco-Cid, Sarai Quiroz-Cruz, Alejandro Escobar-Gutiérrez, Jorge Francisco Cerna-Cortes, Gilberto Vaughan, Salvador Fonseca-Coronado
Single-nucleotide polymorphisms (SNPs) occurring in immune-related genes have been associated with risk or protection for development of dengue, depending on ethnicity. Here, we genotyped seven SNPs located in immune response-related genes to identify their association with severe forms of dengue in patients from an endemic region in Mexico. One hundred and thirty-eight patients with dengue fever (DF), thirty-one dengue hemorrhagic fever (DHF) patients, as well as 304 healthy donors were genotyped by using a TaqMan-based approach...
November 13, 2017: Viral Immunology
https://www.readbyqxmd.com/read/29126886/platinum-palladium-rhodium-molybdenum-and-strontium-in-blood-of-urban-women-in-nine-countries
#13
Gerda Rentschler, Ilia Rodushkin, Milena Cerna, Chunying Chen, Florencia Harari, Raúl Harari, Milena Horvat, Frantiska Hruba, Lucie Kasparova, Kvetoslava Koppova, Andrea Krskova, Mladen Krsnik, Jawhar Laamech, Yu-Feng Li, Lina Löfmark, Thomas Lundh, Nils-Göran Lundström, Badiaa Lyoussi, Darja Mazej, Josko Osredkar, Krystyna Pawlas, Natalia Pawlas, Adam Prokopowicz, Staffan Skerfving, Janja Snoj Tratnik, Vera Spevackova, Zdravko Spiric, Anneli Sundkvist, Ulf Strömberg, Drazenka Vadla, Katerina Wranova, Soumia Zizi, Ingvar A Bergdahl
BACKGROUND: There is little reliable information on human exposure to the metals platinum (Pt), palladium (Pd) and rhodium (Rh), despite their use in enormous quantities in catalytic converters for automobile exhaust systems. OBJECTIVES: To evaluate blood concentrations of Pt (B-Pt), Pd (B-Pd) and Rh (B-Rh) in women from six European and three non-European countries, and to identify potentially influential factors. In addition, molybdenum (Mo) and strontium (Sr) were analysed...
November 2, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29121972/long-noncoding-rna-norad-a-novel-competing-endogenous-rna-enhances-the-hypoxia-induced-epithelial-mesenchymal-transition-to-promote-metastasis-in-pancreatic-cancer
#14
Hongzhe Li, Xinjing Wang, Chenlei Wen, Zhen Huo, Weishen Wang, Qian Zhan, Dongfeng Cheng, Hao Chen, Xiaxing Deng, Chenghong Peng, Baiyong Shen
BACKGROUND: Pancreatic cancer, one of the top two most fatal cancers, is characterized by a desmoplastic reaction that creates a dense microenvironment, promoting hypoxia and inducing the epithelial-to-mesenchymal transition (EMT) to facilitate invasion and metastasis. Recent evidence indicates that the long noncoding RNA NORAD may be a potential oncogenic gene and that this lncRNA is significantly upregulated during hypoxia. However, the overall biological role and clinical significance of NORAD remains largely unknown...
November 9, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/29115574/long-non-coding-rna-snhg1-regulates-nob1-expression-by-sponging-mir-326-and-promotes-tumorigenesis-in-osteosarcoma
#15
Jiandong Wang, Lei Cao, Jianhong Wu, Qiugen Wang
The long non-coding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) has been demonstrated to participate in the deterioration of many types of cancer. However, the underlying mechanisms of SNHG1-mediating functions in osteosarcoma (OS) have yet to be elucidated. In the present study, our results showed that SNHG1 was upregulated in OS tissues and cell lines, and high SNHG1 expression predicts poor overall survival of OS patients. Knockdown of SNHG1 inhibited cell growth and metastasis of OS in vitro and in vivo...
November 3, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29115513/lncrna-pvt1-regulate-expression-of-hif1%C3%AE-via-functioning-as-cerna-for-mir%C3%A2-199a%C3%A2-5p-in-non%C3%A2-small-cell-lung-cancer-under-hypoxia
#16
Chunhong Wang, Chunfang Han, Yibo Zhang, Fengqin Liu
Non‑small cell lung cancer (NSCLC) represents one of the most important causes of cancer mortality in the world, and leads to the largest number of deaths in all kinds of lung cancer. Hypoxia has been confirmed to be a characteristic feature of NSCLC and has been shown to decrease the therapeutic efficacy of radiotherapy and some forms of chemotherapy. Previous studies revealed that many miRNAs have been proven to be involved in the molecular regulation of hypoxia and to affect the protein expression level of HIF‑1α...
November 3, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29113415/the-role-of-mirna-and-lncrna-in-gastric-cancer
#17
REVIEW
Ning-Bo Hao, Ya-Fei He, Xiao-Qin Li, Kai Wang, Rui-Ling Wang
Gastric cancer is one of the most common cancers and has the highest mortality rate worldwide. It is worthwhile to explore the mechanism of gastric cancer progression. An increasing number of studies have found that non-coding RNAs including miRNA and lncRNA play important roles in gastric cancer progression. This review summarized the role of ectopic miRNA in gastric cancer proliferation, growth, migration, invasion and apoptosis. Meantime, aberrantly expressed miRNA also received a great deal of attention as potential biomarker for gastric cancer diagnosis and therapy...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29104512/identification-and-analysis-of-p53-mediated-competing-endogenous-rna-network-in-human-hepatocellular-carcinoma
#18
Yiming Zhang, Ran Kang, Wenrong Liu, Yalan Yang, Ruofan Ding, Qingqing Huang, Junhua Meng, Lili Xiong, Zhiyun Guo
Recent studies have indicated that long non-coding RNAs (lncRNAs) and mRNA function as competing endogenous RNAs (ceRNAs) that compete to bind to shared microRNA (miRNA) recognition elements (MREs) to perform specific biological functions during tumorigenesis. The tumor suppressor p53 is a master regulator of cancer-related biological processes by acting as a transcription factor to regulate target genes including miRNA and lncRNA. However, the mechanism in human hepatocellular carcinoma and whether p53-mediated RNA targets could form ceRNA network remain unclear...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29100339/long-non-coding-rna-hnf1a-as1-promotes-proliferation-and-suppresses-apoptosis-of-bladder-cancer-cells-through-upregulating-bcl-2
#19
Yonghao Zhan, Yifan Li, Bao Guan, Zicheng Wang, Ding Peng, Zhicong Chen, Anbang He, Shiming He, Yanqing Gong, Xuesong Li, Liqun Zhou
Emerging evidences have indicated that long non-coding RNAs (lncRNAs) are pivotal regulators of tumor development and progression. HNF1A-AS1 (HNF1A antisense RNA 1, C12 or f27) is a novel long non-coding RNA that acts as a potential biomarker and is involved in development and progression of several cancers. Nevertheless, we know nothing about the clinical significance and molecular mechanism of HNF1A-AS1 in bladder cancer. In this study, we found that HNF1A-AS1 is significantly up-regulated in bladder cancer...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29100300/long-non-coding-rna-miat-promotes-breast-cancer-progression-and-functions-as-cerna-to-regulate-dusp7-expression-by-sponging-mir-155-5p
#20
Tian Luan, Ximei Zhang, Shuyuan Wang, Yan Song, Shunheng Zhou, Jing Lin, Weiwei An, Weiguang Yuan, Yue Yang, Huilong Cai, Qingyuan Zhang, Lihong Wang
Long non-coding RNAs (lncRNA) have been reported as key regulators in the progression and metastasis of breast cancer. In this study, we found that the lncRNA myocardial infarction associated transcript (MIAT) expression was upregulated in breast cancer in The Cancer Genome Atlas (TCGA) data sets. We validated that MIAT was higher in breast cancer cell lines and advanced breast tumors than in normal controls. And MIAT overexpression associated with TNM stage and lymphnode metastasis. Knockdown MIAT inhibited breast cancer cell proliferation and promoted apoptosis...
September 29, 2017: Oncotarget
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