keyword
MENU ▼
Read by QxMD icon Read
search

ceRNA

keyword
https://www.readbyqxmd.com/read/28624809/genome-wide-analysis-of-aberrantly-expressed-lncrnas-and-mirnas-with-associated-co-expression-and-cerna-networks-in-%C3%AE-thalassemia-and-hereditary-persistence-of-fetal-hemoglobin
#1
Ketong Lai, Siyuan Jia, Shanjuan Yu, Jianming Luo, Yunyan He
The implications of lncRNAs regarding fetal hemoglobin (HbF) induction in hemoglobin disorders remain poorly understood. In this study, microarray analysis was performed to profile lncRNAs, miRNAs and mRNAs in individuals with hereditary persistence of fetal hemoglobin (HPFH), β-thalassemia carriers with high HbF levels and healthy controls. The results show aberrant expression of 862 lncRNAs, 568 mRNAs and 63 miRNAs in the high-HbF group compared with the control group. Altered NR_001589, NR_120526, T315543, miR-486-3p, miR-19b-1-5p and miR-20a-3p expression was confirmed by quantitative reverse transcription-polymerase chain reaction, and Spearman correlation coefficients revealed significant positive correlations with HbF...
May 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28622785/comprehensive-long-non-coding-rna-expression-profiling-reveals-their-potential-roles-in-systemic-lupus-erythematosus
#2
Lian-Ju Li, Wei Zhao, Sha-Sha Tao, Jun Li, Shu-Zhen Xu, Jie-Bing Wang, Rui-Xue Leng, Yin-Guang Fan, Hai-Feng Pan, Dong-Qing Ye
Long non-coding RNAs can regulate gene transcription, modulate protein function, and act as competing endogenous RNA. Yet, their roles in systemic lupus erythematosus remain to be elucidated. We determined the expression profiles of lncRNAs in T cells of SLE patients and healthy controls using microarrays. Up to 1935 lncRNAs and 1977 mRNAs were differentially expressed. QRT-PCR showed downregulated uc001ykl.1 and ENST00000448942 in SLE patients. Expression of uc001ykl.1 correlated with erythrocyte sedimentation rate (ESR) and C-reactive protein, whereas ENST00000448942 level correlated with ESR and anti-Sm antibodies...
June 10, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/28621687/differentially-expressed-lncrnas-and-mirnas-with-associated-cerna-networks-in-aged-mice-with-postoperative-cognitive-dysfunction
#3
Changwei Wei, Ting Luo, Shanshan Zou, Xiaobin Zhou, Wenzhen Shen, Xiaolin Ji, Qi Li, Anshi Wu
Postoperative cognitive dysfunction (POCD) is a common postoperative complication observed in elderly patients. Using microarray analyses, we comprehensively compared long non-coding RNA (lncRNA), messenger RNA (mRNA), and microRNA (miRNA) expression profiles in hippocampal tissues from a mouse model of POCD and control mice. A total of 175 lncRNAs, 117 mRNAs, and 26 miRNAs were differentially expressed between POCD and control mice. Gene ontology (GO) and KEGG pathway enrichment analyses were performed to explore the principal functions of dysregulated genes...
June 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28619512/part-1-functions-as-a-competitive-endogenous-rna-for-promoting-tumor-progression-by-sponging-mir-143-in-colorectal-cancer
#4
Yongbo Hu, Zhen Ma, Yiming He, Wei Liu, Yu Su, Zongbin Tang
LncRNAs were altered in several cancers and played a crucial role in various biological activities and progressions of different diseases, including proliferation, chemical resistance, and metastasis. In the present study, we revealed that prostrate androgen-regulated transcript-1 (PART-1) was highly expressed in colorectal cancer cells and tissues, and knockdown of PART-1 suppressed cell proliferation and metastasis, both in vitro and in vivo. In addition, PART-1 functioned as a ceRNA of DNMT3A, by sponging miR-143...
June 12, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28607615/diffuse-interstitial-fibrosis-assessed-by-cardiac-magnetic-resonance-is-associated-with-dispersion-of-ventricular-repolarization-in-patients-with-hypertrophic-cardiomyopathy
#5
David Hurtado-de-Mendoza, Celia P Corona-Villalobos, Iraklis Pozios, Jorge Gonzales, Yalda Soleimanifard, Sanjay Sivalokanathan, Diego Montoya-Cerrillo, Styliani Vakrou, Ihab Kamel, Wilfredo Mormontoy-Laurel, Ketty Dolores-Cerna, Jacsel Suarez, Sergio Perez-Melo, David A Bluemke, Theodore P Abraham, Stefan L Zimmerman, M Roselle Abraham
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is characterized by myocyte hypertrophy, disarray, fibrosis, and increased risk for ventricular arrhythmias. Increased QT dispersion has been reported in patients with HCM, but the underlying mechanisms have not been completely elucidated. In this study, we examined the relationship between diffuse interstitial fibrosis, replacement fibrosis, QTc dispersion and ventricular arrhythmias in patients with HCM. We hypothesized that fibrosis would slow impulse propagation and increase dispersion of ventricular repolarization, resulting in increased QTc dispersion on surface electrocardiogram (ECG) and ventricular arrhythmias...
June 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/28602827/microrna-inhibitors-natural-and-artificial-sequestration-of-microrna
#6
Li Tang, Hong-Yan Chen, Ling-Bo Hao, Bo Tang, Hong Guo, Xin Yong, Hui Dong, Shi-Ming Yang
MicroRNA (miRNAs) is post-transcriptional regulator of mRNA. However, the prevalence and activity of miRNA are regulated by other regulators. miRNA inhibitors are natural or artificial RNA transcripts that sequestrate miRNAs and decrease or even eliminate miRNA activity. Competing endogenous RNAs (ceRNAs) are natural and intracellular miRNA inhibitors that compete to bind to shared miRNA recognition elements (MREs) to decrease microRNA availability and relieve the repression of target RNAs. In recent years, studies have revealed that ceRNA crosstalk is involved in many pathophysiological processes and adds a new dimension to miRNA regulation...
June 8, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28592847/tgf-%C3%AE-induced-hepatocyte-lincrna-p21-contributes-to-liver-fibrosis-in-mice
#7
Xiaolong Tu, Yuanyuan Zhang, Xiuxiu Zheng, Jia Deng, Huanan Li, Zhiqian Kang, Zhipeng Cao, Zhen Huang, Zhi Ding, Lei Dong, Jiangning Chen, Yuhui Zang, Junfeng Zhang
Hepatocyte death, as well as the following inflammatory and fibrogenic signaling cascades, is the key trigger of liver fibrosis. Here, we isolated hepatocytes from CCl4-induced fibrotic liver and found that hepatocyte lincRNA-p21 significantly increased during liver fibrosis. The increase of hepatocyte lincRNA-p21 was associated with the loss of miR-30, which can inhibit TGF-β signaling by targeting KLF11. We revealed that lincRNA-p21 modulated miR-30 availability by acting as a competing endogenous RNA (ceRNA)...
June 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28580169/endogenous-mirna-sponge-lincrna-ror-promotes-proliferation-invasion-and-stem-cell-like-phenotype-of-pancreatic-cancer-cells
#8
Zhiqiang Fu, Guolin Li, Zhihua Li, Yingxue Wang, Yue Zhao, Shangyou Zheng, Huilin Ye, Yuming Luo, Xiaohui Zhao, Lusheng Wei, Yimin Liu, Qing Lin, Quanbo Zhou, Rufu Chen
The long intergenic non-coding RNA, regulator of reprogramming (linc-ROR) is an oncogene and plays a key role in the embryonic stem cell maintenance and is involved in cancer progression. The objective of this study was to analyze linc-ROR expression in pancreatic ductal adenocarcinoma (PDAC) and determine the regulation effects of linc-ROR on proliferation and invasion of cancer cells, as well as properties of cancer stem-like cells (CSLCs). In this study, we found that linc-ROR was up-regulated in PDAC tissues and related to poor prognosis...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28575144/cernas-in-plants-computational-approaches-and-associated-challenges-for-target-mimic-research
#9
Alexandre Rossi Paschoal, Irma Lozada-Chávez, Douglas Silva Domingues, Peter F Stadler
The competing endogenous RNA hypothesis has gained increasing attention as a potential global regulatory mechanism of microRNAs (miRNAs), and as a powerful tool to predict the function of many noncoding RNAs, including miRNAs themselves. Most studies have been focused on animals, although target mimic (TMs) discovery as well as important computational and experimental advances has been developed in plants over the past decade. Thus, our contribution summarizes recent progresses in computational approaches for research of miRNA:TM interactions...
May 30, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/28564590/long-intergenic-non-coding-rna-668-regulates-vegfa-signaling-through-inhibition-of-mir-297-in-oral-squamous-cell-carcinoma
#10
Chen-Zheng Zhang
Recently, long noncoding RNAs (lncRNAs) have been reported to have crucial regulatory efficiency in human cancer biology. Long intergenic non-coding RNA 668 (LINC00668) was regarded as an oncogene in multiple cancers. However, the underlying molecular mechanism of LINC00668 in oral squamous cell carcinoma (OSCC) has not been studied. In this study, we first demonstrated that LINC00668 expression was up-regulated, which was correlated with tumor progression, and miR-297 down-regulated in OSCC tissues and cells...
May 28, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28558729/high-throughput-validation-of-cerna-regulatory-networks
#11
Hua-Sheng Chiu, María Rodríguez Martínez, Mukesh Bansal, Aravind Subramanian, Todd R Golub, Xuerui Yang, Pavel Sumazin, Andrea Califano
BACKGROUND: MicroRNAs (miRNAs) play multiple roles in tumor biology. Interestingly, reports from multiple groups suggest that miRNA targets may be coupled through competitive stoichiometric sequestration. Specifically, computational models predicted and experimental assays confirmed that miRNA activity is dependent on miRNA target abundance, and consequently, changes in the abundance of some miRNA targets lead to changes to the regulation and abundance of their other targets. The resulting indirect regulatory influence between miRNA targets resembles competition and has been dubbed competitive endogenous RNA (ceRNA)...
May 30, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28550684/long-noncoding-rna-ccat2-knockdown-suppresses-tumorous-progression-by-sponging-mir-424-in-epithelial-ovarian-vancer
#12
Fu Hua, Chang-Hua Li, Xiao-Gang Chen, Xiao-Ping Liu
Epithelial ovarian cancer (EOC) is the one of most common gynecological malignant tumor with highest mortality, meanwhile, series of lncRNAs have been validated to play vital role in EOC tumorigenesis. Colon cancer-associated transcript 2 (CCAT2) has been verified as oncogenic lncRNA in multiple tumors, however, the role of CCAT2 in EOC genesis is still unclear. The purpose of present study is to probe the function of CCAT2 on EOC. Preliminary experiments found that CCAT2 expression was significantly up-regulated in EOC tissue and cell lines compared to noncancerous tissue and cells...
May 21, 2017: Oncology Research
https://www.readbyqxmd.com/read/28539329/aberrant-methylation-mediated-silencing-of-lncrna-meg3-functions-as-a-cerna-in-esophageal-cancer
#13
Zhiming Dong, Aili Zhang, Shengnan Liu, Fan Lu, Yanli Guo, Guoqiang Zhang, Fenglou Xu, Yabin Shi, Supeng Shen, Jia Liang, Wei Guo
Maternally expressed gene 3 (MEG3), a long non-coding RNA (lncRNA), has tumor suppressor properties and its expression is lost in several human tumors. However, its biological role in esophageal squamous cell carcinoma (ESCC) tumorigenesis is poorly defined. The present study determined the role and methylation status of MEG3 in esophageal cancer cells and ESCC clinical specimens, and further observed the competing endogenous RNA (ceRNA) activity of MEG3 in the pathogenesis and development of ESCC. Significant down-regulation of MEG3 was detected in esophageal cancer cells and ESCC tissues and the expression level of MEG3 was significantly increased in cancer cells after treated with the DNA methyltransferase inhibitor 5-Aza-dC...
May 24, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28526941/urinary-cadmium-and-cotinine-levels-and-hair-mercury-levels-in-czech-children-and-their-mothers-within-the-framework-of-the-cophes-democophes-projects
#14
Kateřina Forysová, Anna Pinkr-Grafnetterová, Marek Malý, Andrea Krsková, Jaroslav Mráz, Lucie Kašparová, Mája Čejchanová, Lenka Sochorová, Sylva Rödlová, Milena Černá
The COPHES/DEMOCOPHES twin project was performed in 2011-2012 in 17 European countries to harmonize all steps of the human biomonitoring survey. Urinary cadmium, cotinine, phthalate metabolites, and hair mercury were measured in children (N = 120, 6-11 years) and their mothers of reproductive age, living in urban or rural areas. Cadmium in mothers' and children's urine was detected at a geometric mean (GM) concentration 0.227 and 0.109 μg/L, respectively; 95th percentile (P95) was 0.655 and 0.280 μg/L in mothers and children, respectively...
May 19, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28524360/lamc1-mrna-promotes-malignancy-of-hepatocellular-carcinoma-cells-by-competing-for-microrna-124-binding-with-cd151
#15
Zhan-Po Yang, Hong-Shun Ma, Shu-Sen Wang, Le Wang, Tao Liu
Specific RNAs can function as sinks for endogenous miRNAs, known as competing endogenous RNAs (ceRNAs). Here, we confirm a miR-124 mediated ceRNA crosstalk between LAMC1 and CD151 in hepatocellular carcinoma (HCC). miR-124 negatively regulates LAMC1 expression through two miRNA binding sites within its 3' untranslated region (3'UTR) and suppresses migration and invasion of HCC cells through regulating LAMC1. The wild type LAMC1 miRNA response elements (MREs) facilitate expression of CD151, and this regulation is miR-124 dependent...
May 19, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28510638/%C3%AE-asarone-suppresses-the-proliferation-and-migration-of-asmcs-through-targeting-the-lncrna-pvt1-mir-203a-e2f3-signal-pathway-in-rsv-infected-rats
#16
Xiao Yu, Zhe Zhe, Binqing Tang, Shaobin Li, Ling Tang, Yingen Wu, Xiaorong Chen, Hong Fang
Asthma is a chronic inflammatory pulmonary disease and respiratory syncytial virus (RSV) infection is a common cause of lower respiratory tract illness in infants and young children. α-Asarone presents many pharmacological effects and has been demonstrated to be useful in treating asthma. However, the functional mechanism of α-asarone in RSV-infected asthma has not been investigated. Long non-coding RNAs (lncRNAs) have been reported to play critical roles in many biological processes. Although many lncRNAs have been characterized, few were reported in asthma, especially in RSV-induced asthma...
May 16, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28501870/long-non-coding-rna-xloc_008466-functions-as-an-oncogene-in-human-non-small-cell-lung-cancer-by-targeting-mir-874
#17
Rui Yang, Ping Li, Guojun Zhang, Chunya Lu, Huaqi Wang, Guoqiang Zhao
BACKGROUND: The therapy and prognosis of lung cancer are difficult because of multiple genetic and epigenetic alterations. Long non-coding RNAs (lncRNAs) have been verified as new mediators of cancer development and progression by virtue of their various functions. Here, we focused on the lncRNA XLOC_008466 based on previous microarray data. However, whether aberrant expression of XLOC_008466 in human non-small cell lung cancer (NSCLC) is correlated with malignancy, metastasis or prognosis has not been elucidated...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28495512/modulation-of-casc2-mir-21-pten-pathway-sensitizes-cervical-cancer-to-cisplatin
#18
Yeqian Feng, Wen Zou, Chunhong Hu, Guiyuan Li, Shenghua Zhou, Yan He, Fang Ma, Chao Deng, Lili Sun
Cisplatin (DDP) -based chemotherapy is a standard strategy for cervical cancer, while chemoresistance remains a challenge. Recent evidence highlights the crucial regulatory roles of long non-coding RNAs (lncRNA) in tumor biology. However, the roles and regulatory mechanisms of the novel lncRNA, cancer susceptibility candidate 2 (CASC2), in cervical cancer tumorigenesis and chemoresistance are poorly understood. In this study, CASC2 expression was down-regulated in cervical cancer tissues, and was related to a shorter survival time and poorer clinicopathologic features...
June 1, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28492542/lncrna-hotair-regulates-hif-1%C3%AE-axl-signaling-through-inhibition-of-mir-217-in-renal-cell-carcinoma
#19
Quan Hong, Ou Li, Wei Zheng, Wen-Zhen Xiao, Lu Zhang, Di Wu, Guang-Yan Cai, John Cijiang He, Xiang-Mei Chen
Long non-coding RNA HOTAIR was regarded as an oncogene in multiple cancers. Previous studies have shown that HOTAIR is involved in the proliferation and tumorigenesis of renal carcinoma cells, while microRNA (miR)-217 functions as a tumor suppressor in renal cell carcinoma (Rcc). However, the underlying molecular mechanism of HOTAIR in Rcc, especially in association with miR-217, has not been studied. In this study, we first demonstrated that HOTAIR expression was upregulated, which was correlated with tumor progression, and miR-217 downregulated in Rcc tissues and cells...
May 11, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28489863/combining-phylogenetic-and-demographic-inferences-to-assess-the-origin-of-the-genetic-diversity-in-an-isolated-wolf-population
#20
Luca Montana, Romolo Caniglia, Marco Galaverni, Elena Fabbri, Atidje Ahmed, Barbora Černá Bolfíková, Sylwia D Czarnomska, Ana Galov, Raquel Godinho, Maris Hindrikson, Pavel Hulva, Bogumiła Jędrzejewska, Maja Jelenčič, Miroslav Kutal, Urmas Saarma, Tomaž Skrbinšek, Ettore Randi
The survival of isolated small populations is threatened by both demographic and genetic factors. Large carnivores declined for centuries in most of Europe due to habitat changes, overhunting of their natural prey and direct persecution. However, the current rewilding trends are driving many carnivore populations to expand again, possibly reverting the erosion of their genetic diversity. In this study we reassessed the extent and origin of the genetic variation of the Italian wolf population, which is expanding after centuries of decline and isolation...
2017: PloS One
keyword
keyword
12313
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"