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https://www.readbyqxmd.com/read/28333080/a-review-epigenetic-mechanism-in-ochratoxin-a-toxicity-studies
#1
REVIEW
Liye Zhu, Boyang Zhang, Yaqi Dai, Hongyu Li, Wentao Xu
Ochratoxin A (OTA) is a natural contaminant that has displayed nephrotoxicity and hepatotoxicity in mammals. It contaminates a great variety of foodstuffs and threatens people's lives. The molecular mechanism of OTA-induced toxicity has been studied since 1965. Moreover, epigenetic mechanisms are also studied in OTA-induced toxicity. Additionally, the mode of OTA epigenetic research has been advanced in research hotspots. However, there is still no epigenetic study of OTA-induced toxicity. In this review, we discuss the relationship between these epigenetic mechanisms and OTA-induced toxicity...
March 23, 2017: Toxins
https://www.readbyqxmd.com/read/28322996/assessing-the-mirna-sponge-potential-of-runx1t1-in-t-8-21-acute-myeloid-leukemia
#2
Alexander Junge, Roza Zandi, Jakob Hull Havgaard, Jan Gorodkin, Jack Bernard Cowland
t(8;21) acute myeloid leukemia (AML) is characterized by a translocation between chromosomes 8 and 21 and formation of a distinctive RUNX1-RUNX1T1 fusion transcript. This translocation places RUNX1T1 under control of the RUNX1 promoter leading to a pronounced upregulation of RUNX1T1 transcripts in t(8;21) AML, compared to normal hematopoietic cells. We investigated the role of highly-upregulated RUNX1T1 under the hypothesis that it acts as competing endogenous RNA (ceRNA) titrating microRNAs (miRNAs) away from their target transcripts and thus contributes to AML formation...
March 16, 2017: Gene
https://www.readbyqxmd.com/read/28321591/naked-in-the-old-and-the-new-world-differences-and-analogies-in-descriptions-of-european-and-american-herbae-nudae-in-the-sixteenth-century
#3
Lucie Čermáková, Jana Černá
The sixteenth century could be understand as a period of renaissance of interest in nature and as a period of development of natural history as a discipline. The spreading of the printing press was connected to the preparation of new editions of Classical texts and to the act of correcting and commenting on these texts. This forced scholars to confront texts with living nature and to subject it to more careful investigation. The discovery of America uncovered new horizons and brought new natural products, which were exotic and unknown to Classical tradition...
March 20, 2017: Journal of the History of Biology
https://www.readbyqxmd.com/read/28318703/duodenal-gangliocytic-paraganglioma-treatment-through-endoscopic-resection
#4
B D Palomino-Martínez, H Espino-Cortés, J Cerna-Cardona, L E Godínez-Martínez, M A Chávez-García
No abstract text is available yet for this article.
March 16, 2017: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/28316060/hotair-functions-as-a-competing-endogenous-rna-to-regulate-pten-expression-by-inhibiting-mir-19-in-cardiac-hypertrophy
#5
Yanjun Lai, Shuai He, Liming Ma, Hong Lin, Biyun Ren, Jing Ma, Xinyu Zhu, Shifang Zhuang
Sustained cardiac hypertrophy (CH) is related to a variety of physiological as well as pathological stimuli and eventually increases the risk of heart failure. HOTAIR has been identified as a competing endogenous RNA in multiple human biological processes. Whether lncRNA-HOTAIR is involved in the progress of CH and how it works still remain unknown. Herein, we found that HOTAIR was down-regulated, while miR-19 was up-regulated in both heart tissues from TAC-operated mice in vivo and cultural cardiomyocytes treated with Ang-II in vitro by real-time PCR...
March 18, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28302487/tug1-mediates-methotrexate-resistance-in-colorectal-cancer-via-mir-186-cpeb2-axis
#6
Changfeng Li, Yongjian Gao, Yongchao Li, Dayong Ding
Colorectal cancer (CRC) is a common malignancy, most of which remain unresponsive to chemotherapy. Methotrexate (MTX) is one of the earliest cytotoxic drugs and serves as an anti-metabolite and anti-folate chemotherapy for various types of cancer. However, MTX resistance prevents its clinical application in cancer therapy. Thereby, overcoming the drug resistance is an alternative strategy to maximize the efficacy of MTX therapies in clinics. Long non-coding RNAs (lncRNAs) have gained widespread attention in recent years...
March 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28292523/exercise-qtc-is-associated-with-diffuse-interstitial-fibrosis-reflected-by-lower-approximated-t1-relaxation-time-in-hypertrophic-cardiomyopathy-patients
#7
Celia P Corona-Villalobos, Sudip Saha, Iraklis Pozios, David Hurtado-de-Mendoza Paz, Lars Sorensen, Jorge Gonzalez Cordoba, Ketty Dolores-Cerna, Ihab R Kamel, Wilfredo Mormontoy Laurel, David A Bluemke, Theodore P Abraham, Stefan L Zimmerman, M Roselle Abraham
No abstract text is available yet for this article.
February 12, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28281877/comprehensive-analysis-of-interaction-networks-of-telomerase-reverse-transcriptase-with-multiple-bioinformatic-approach-deep-mining-the-potential-functions-of-telomere-and-telomerase
#8
Chunyu Hou, Fei Wang, Xuewen Liu, Guangming Chang, Feng Wang, Xin Geng
Telomerase reverse transcriptase (TERT)is the protein component of telomerase complex. Evidence has accumulated showing that the non-telomeric functions of TERT are independent of telomere elongation. However, the mechanisms governing the interaction between TERT and its target genes are not revealed clear. The biological functions of TERT are not fully elucidated and have thus far been underestimated. To further explore these functions, we investigated TERT interaction networks using multiple bioinformatic databases, including BioGRID, STRING, DAVID, GeneCards, GeneMANIA, PANTHER, miRWalk, mirTarBase, miRNet, miRDB and TargetScan...
March 6, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28281528/lnc-mg-is-a-long-non-coding-rna-that-promotes-myogenesis
#9
Mu Zhu, Jiafan Liu, Jia Xiao, Li Yang, Mingxiang Cai, Hongyu Shen, Xiaojia Chen, Yi Ma, Sumin Hu, Zuolin Wang, An Hong, Yingxian Li, Yao Sun, Xiaogang Wang
Recent studies indicate important roles for long noncoding RNAs (lncRNAs) as essential regulators of myogenesis and adult skeletal muscle regeneration. However, the specific roles of lncRNAs in myogenic differentiation of adult skeletal muscle stem cells and myogenesis are still largely unknown. Here we identify a lncRNA that is specifically enriched in skeletal muscle (myogenesis-associated lncRNA, in short, lnc-mg). In mice, conditional knockout of lnc-mg in skeletal muscle results in muscle atrophy and the loss of muscular endurance during exercise...
March 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/28276319/long-non-coding-rna-crnde-promotes-multiple-myeloma-cell-growth-by-suppressing-mir-451
#10
Yi-Bin Meng, Xin He, Yun-Fei Huang, Qi-Ning Wu, Yong-Cun Zhou, Ding-Jun Hao
Long non-coding RNAs (lncRNAs) have been determinately identified as potential regulatory factor in multiple tumors, aswell as multiple myeloma (MM). However, the role of colorectal neoplasia differentially expressed (CRNDE) in pathogenesis of MM remains unclear. In this study, we found that the CRNDE expression level, in MM sample and cell lines, is higher than control detected by real-time qPCR, which is also closely related to tumor progression and poor survival in MM patients. Afterwards, knockdown of CRNDE significantly inhibits the proliferative vitality of MM cells (U266 and RPMI8226), meanwhile, induces cell cycle arrest in G0/G1 phase and apoptosis-promoting...
March 9, 2017: Oncology Research
https://www.readbyqxmd.com/read/28276316/long-noncoding-rna-meg3-suppresses-glioma-cell-proliferation-migration-and-invasion-by-acting-as-competing-endogenous-rna-of-mir-19a
#11
Gui-Feng Tong, Nan Qin, Li-Wei Sun, Xiao-Lin Xu
Glioma, with varying malignancy grades and histological subtypes, is the commonest primary brain tumor in adults. Longnon-coding RNAs (lncRNAs) are non-protein-coding transcripts and have been proven to play important roles in tumorigenesis. Our study aims to elucidate the combined effect of lncRNA MEG3 and microRNA-19a in human glioma U87 and U251 cell lines. Real time PCR revealed that MEG3 was down-regulated and miR-19a was up-regulated in malignant glioma tissues and cell lines. Bioinformatics analyses (TargetScan, miRanda and starBase V2...
March 8, 2017: Oncology Research
https://www.readbyqxmd.com/read/28276314/long-non-coding-rna-pvt1-facilitates-cervical-cancer-progression-via-negative-regulating-of-mir-424
#12
Ya-Li Gao, Zi-Shen Zhao, Ming-Yun Zhang, Li-Jie Han, Yu-Jin Dong, Bo Xu
Emerging evidence suggests that the long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 gene (PVT1) is involved in pathogenesis of cervical cancer. However, the potential mechanism is rarely reported. Our study found that PVT1 was up-regulated in cervical cancer tissue and cell lines. After transfecting PVT1 siRNA, the proliferation, migration and invasion of cervical cancer cells were markedly decreased. MiRNA expression profiles demonstrate that miR-424 was markedly down-regulated in cervical cancer tissue...
March 8, 2017: Oncology Research
https://www.readbyqxmd.com/read/28272965/regulation-of-4e-bp1-activity-in-the-mammalian-oocyte
#13
Denisa Jansova, Marketa Koncicka, Anna Tetkova, Renata Cerna, Radek Malik, Edgar Del Llano, Michal Kubelka, Andrej Susor
Fully grown mammalian oocytes utilize transcripts synthetized and stored during earlier development. RNA localization followed by a local translation is a mechanism responsible for the regulation of spatial and temporal gene expression. Here we show that the mouse oocyte contains three forms of cap-dependent translational repressor expressed on the mRNA level: 4E-BP1, 4E-BP2 and 4E-BP3. However, only 4E-BP1 is present as a protein in oocytes, it becomes inactivated by phosphorylation after nuclear envelope breakdown and as such it promotes cap-dependent translation after NEBD...
March 8, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28266541/cerna-crosstalk-stabilizes-protein-expression-and-affects-the-correlation-pattern-of-interacting-proteins
#14
Araks Martirosyan, Andrea De Martino, Andrea Pagnani, Enzo Marinari
Gene expression is a noisy process and several mechanisms, both transcriptional and post-transcriptional, can stabilize protein levels in cells. Much work has focused on the role of miRNAs, showing in particular that miRNA-mediated regulation can buffer expression noise for lowly expressed genes. Here, using in silico simulations and mathematical modeling, we demonstrate that miRNAs can exert a much broader influence on protein levels by orchestrating competition-induced crosstalk between mRNAs. Most notably, we find that miRNA-mediated cross-talk (i) can stabilize protein levels across the full range of gene expression rates, and (ii) modifies the correlation pattern of co-regulated interacting proteins, changing the sign of correlations from negative to positive...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28263536/effectiveness-of-human-cytochrome-p450-3a4-present-in-liposomal-and-microsomal-nanoparticles-in-formation-of-covalent-dna-adducts-by-ellipticine
#15
Miroslav Sulc, Iveta Mrizova, Tereza Cerna, Eva Frei, Tomas Eckschlager, Vojtech Adam, Katerina Kopeckova, Marie Stiborova
OBJECTIVES: Ellipticine is an anticancer agent that functions through multiple mechanisms participating in cell cycle arrest and initiation of apoptosis. This drug forms covalent DNA adducts after its enzymatic activation with cytochrome P450 (CYP), which is one of the most important ellipticine DNA-damaging mechanisms of its cytotoxic effects. The improvements of cancer treatment are the major challenge in oncology research. Nanotransporters (nanoparticles) are promising approaches to target tumor cells, frequently leading to improve drug therapeutic index...
December 18, 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28260460/sirolimus-induced-combined-posterior-reversible-encephalopathy-syndrome-and-lymphocytic-pneumonitis-in-a-renal-transplant-recipient-case-report-and-review-of-the-literature
#16
Osama Gheith, Magdalena Cerna, Medhat A Halim, Narayanam Nampoory, Torki Al-Otaibi, Prasad Nair, Tarek Said, Hassanein Abo Atteya, Kenneth Katchy
The mammalian target of rapamycin inhibitor sirolimus was introduced into clinical transplant practice in 1999. Dose-related myelosuppression and hyper lipidemia are the most common adverse effects. Pulmonary toxicity has been reported since 2004 and can cause interstitial pneumonitis, organizing pneumonia, and alveolar hemorrhage. Moreover, it can occasionally induce posterior reversible encephalopathy syndrome, as documented in scarce reports. To our knowledge; this is the 1st report of combined posterior reversible encephalopathy syndrome and lymphocytic pneumonitis to be induced by sirolimus...
February 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28244999/exposure-to-airborne-fungi-during-sorting-of-recyclable-plastics-in-waste-treatment-facilities
#17
Kristýna Černá, Zdeňka Wittlingerová, Magdaléna Zimová, Zdeněk Janovský
BACKGROUND: In working environment of waste treatment facilities, employees are exposed to high concentrations of airborne microorganisms. Fungi constitute an essential part of them. This study aims at evaluating the diurnal variation in concentrations and species composition of the fungal contamination in 2 plastic waste sorting facilities in different seasons. MATERIAL AND METHODS: Air samples from the 2 sorting facilities were collected through the membrane filters method on 4 different types of cultivation media...
February 28, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28242294/the-bipo-3-detector
#18
P Loaiza, A S Barabash, A Basharina-Freshville, E Birdsall, S Blondel, S Blot, M Bongrand, D Boursette, V Brudanin, J Busto, A J Caffrey, S Calvez, M Cascella, C Cerna, E Chauveau, A Chopra, S De Capua, D Duchesneau, D Durand, V Egorov, G Eurin, J J Evans, L Fajt, D Filosofov, R Flack, X Garrido, H Gómez, B Guillon, P Guzowski, K Holý, R Hodák, A Huber, C Hugon, A Jeremie, S Jullian, M Kauer, A Klimenko, O Kochetov, S I Konovalov, V Kovalenko, K Lang, Y Lemière, T Le Noblet, Z Liptak, X R Liu, G Lutter, M Macko, F Mamedov, C Marquet, F Mauger, B Morgan, J Mott, I Nemchenok, M Nomachi, F Nova, H Ohsumi, G Oliviéro, R B Pahlka, J Pater, F Perrot, F Piquemal, P Povinec, P Přidal, Y A Ramachers, A Remoto, B Richards, C L Riddle, E Rukhadze, R Saakyan, X Sarazin, Yu Shitov, L Simard, F Šimkovic, A Smetana, K Smolek, A Smolnikov, S Söldner-Rembold, B Soulé, I Štekl, J Thomas, V Timkin, S Torre, Vl I Tretyak, V I Tretyak, V I Umatov, C Vilela, V Vorobel, D Waters, A Žukauskas
The BiPo-3 detector is a low radioactive detector dedicated to measuring ultra-low natural contaminations of (208)Tl and (214)Bi in thin materials, initially developed to measure the radiopurity of the double β decay source foils of the SuperNEMO experiment at the μBq/kg level. The BiPo-3 technique consists in installing the foil of interest between two thin ultra-radiopure scintillators coupled to low radioactive photomultipliers. The design and performances of the detector are presented. In this paper, the final results of the (208)Tl and (214)Bi activity measurements of the first enriched (82)Se foils are reported for the first time, showing the capability of the detector to reach sensitivities in the range of some μBq/kg...
January 29, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28241741/differential-correlation-analysis-of-glioblastoma-reveals-immune-cerna-interactions-predictive-of-patient-survival
#19
Yu-Chiao Chiu, Li-Ju Wang, Tzu-Pin Lu, Tzu-Hung Hsiao, Eric Y Chuang, Yidong Chen
BACKGROUND: Recent studies illuminated a novel role of microRNA (miRNA) in the competing endogenous RNA (ceRNA) interaction: two genes (ceRNAs) can achieve coexpression by competing for a pool of common targeting miRNAs. Individual biological investigations implied ceRNA interaction performs crucial oncogenic/tumor suppressive functions in glioblastoma multiforme (GBM). Yet, a systematic analysis has not been conducted to explore the functional landscape and prognostic significance of ceRNA interaction...
February 28, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28238937/sp1-is-a-competitive-endogenous-rna-of-klf4-during-odontoblast-differentiation
#20
Jie Zhang, Huan Liu, Heng Lin, Shuchen Li, Huangheng Tao, Lu Zhang, Guohua Yuan, Zhi Chen
Our previous studies have demonstrated that KLF4 is a critical transcription factor that promotes the odontoblastic differentiation of dental papilla cells. Klf4 mRNA was found to be regulated by multiple microRNAs (miRNAs). Competitive endogenous RNAs (ceRNAs) are a group of transcripts post-transcriptionally regulating each other by competing for their common miRNAs. However, the regulation of Klf4 by ceRNAs in odontoblastic differentiation remains unknown. In this study, we predicted a group of potential Klf4 ceRNAs with bioinformatics approach, and examined the expression of Klf4 and five interested potential ceRNAs including Sp1 using real-time PCR during odontoblastic differentiation of mDPC6T...
February 24, 2017: International Journal of Biochemistry & Cell Biology
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