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https://www.readbyqxmd.com/read/29924678/bleeding-at-removal-of-nuss-bar-rare-but-sometimes-significant
#1
Nina S Cohen, Michael J Goretsky, Robert J Obermeyer
BACKGROUND: Hemorrhage during Nuss bar removal is an uncommon but feared complication that can be life threatening if not controlled rapidly. This study aims to identify the incidence and sources of large volume hemorrhage, discuss successful management strategies, and provide patient care recommendations. METHODS: An IRB approved (#15-11-WC-0214), single institution retrospective chart review was performed on patients who underwent Nuss bar removal over a 15-year interval...
June 20, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29924011/clinical-inertia-in-the-pharmacological-management-of-hypertension-a-systematic-review-and-meta-analysis
#2
Tal Milman, Raed A Joundi, Naif M Alotaibi, Gustavo Saposnik
BACKGROUND: Clinical Inertia is defined as "failure of health care providers to initiate or intensify therapy according to current guidelines". This phenomenon is gaining increasing attention as a major cause of clinicians' failure to adequately manage hypertension, thus leading to an increased incidence of cardiovascular events. We performed a systematic review and meta-analysis of randomized controlled trials to determine whether interventions aimed at reducing clinical inertia in the pharmacological treatment of hypertension improve blood pressure (BP) control...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923533/diabetes-self-care-activities-among-adults-20-years-and-above-residing-in-a-resettlement-colony-in-east-delhi
#3
Anu Mohandas, S K Bhasin, Madhu Upadhyay, S V Madhu
Background: Self-care activities are the cornerstone of diabetes care that ensures patients participation to achieve optimal glycemic control and to prevent complications. Objective: The aim of this study is to find the level of self-care activities among diabetics aged ≥20 years residing in a resettlement colony in East Delhi and its association with sociodemographic factors, disease, and treatment profile. Methods: Using cross-sectional survey, 168 known diabetic patients were selected from Nand Nagri, a resettlement colony in East Delhi...
April 2018: Indian Journal of Public Health
https://www.readbyqxmd.com/read/29923457/arginase-i-mrna-therapy-a-novel-approach-to-rescue-arginase-1-enzyme-deficiency
#4
Kirtika H Asrani, Lei Cheng, Christopher J Cheng, Romesh R Subramanian
Arginase I (ARG1) deficiency is an autosomal recessive urea cycle disorder, caused by deficiency of the enzyme Arginase I, resulting in accumulation of arginine in blood. Current Standard of Care (SOC) for ARG1 deficiency in patients or those having detrimental mutations of ARG1 gene is diet control. Despite diet and drug therapy with nitrogen scavengers, ~25% of patients suffer from severe mental deficits and loss of ambulation. 75% of patients whose symptoms can be managed through diet therapy continue to suffer neuro-cognitive deficits...
June 20, 2018: RNA Biology
https://www.readbyqxmd.com/read/29923016/incidence-and-management-of-postoperative-hyperglycemia-in-patients-undergoing-insulinoma-resection
#5
Pavel Nockel, Amit Tirosh, Mustapha El Lakis, Apostolos Gaitanidis, Roxanne Merkel, Dhaval Patel, Naris Nilubol, Samira M Sadowski, Craig Cochran, Phillip Gorden, Electron Kebebew
PURPOSE: It has been proposed that rebound hyperglycemia after resection of insulinoma indicates a biochemical cure. However, there is scant objective data in the literature on the rate and need for intervention in hyperglycemia in patients undergoing resection of insulinoma. The goal of our study was to evaluate the rate of postoperative hyperglycemia, any predisposing factors, and the need for intervention in a prospective cohort study of all patients undergoing routine glucose monitoring...
June 19, 2018: Endocrine
https://www.readbyqxmd.com/read/29922595/immunemodulatory-effects-of-5-azacitidin-through-expansion-of-functional-regulatory-t-cells-on-paraneoplastic-inflammation-associated-with-myelodysplastic-syndromes-a-case-report
#6
Kentaro Serizawa, Hirokazu Tanaka, Yasuyoshi Morita, Takahide Taniguchi, Takashi Ashida, Itaru Matsumura
Myelodysplastic syndrome (MDS) is a heterogeneous group of clonal disorders of hematopoietic stem cells, characterized by dysplastic hematopoiesis and dysregulated immune system resulting in various clinical conditions. Paraneoplastic inflammatory syndromes, which are well known to be associated with MDS, show response to immune-modulated therapy and often disappear during the course of hematologic management. Azacitidine (5-Aza) was shown to prolong survival of high-risk MDS patients, however, the effects of 5-Aza on paraneoplastic inflammation in MDS have yet to be elucidated...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29922571/careful-interpretation-of-the-wound-status-is-needed-with-use-of-antibiotic-impregnated-biodegradable-synthetic-pure-calcium-sulfate-beads-series-of-39-cases
#7
Aditya Menon, Rajeev Soman, Camilla Rodrigues, Sanjay Phadke, Vikas M Agashe
Introduction: The use of antibiotic impregnated biodegradable synthetic high purity calcium sulfate (SHPCS) beads is frequently reported as they offer increased concentration of antibiotics locally, without need for removal. However some wound discharge following their use has been noted. The purpose of this study was to determine any correlation between wound discharge and infection remission. Methodology: Retrospective study of 39 cases of Osteoarticular infections from April 2013 to November 2016 in whom SHPCS beads were used...
2018: Journal of Bone and Joint Infection
https://www.readbyqxmd.com/read/29922396/effect-of-intracranial-stenosis-revascularization-on-dynamic-and-static-cerebral-autoregulation
#8
Santiago Ortega-Gutierrez, Edgar A Samaniego, Amy Huang, Arjun Masurkar, Binbin Zheng-Lin, Colin P Derdeyn, David Hasan, Randolph Marshall, Nils Petersen
Introduction: Severe intracranial stenosis might lead to acute cerebral ischemia. It is imperative to better assess patients who may benefit from immediate reperfusion and blood pressure management to prevent injury to peri-infarct tissue. Methods: We assessed cerebral autoregulation using static and dynamic methods in an 81-year-old woman suffering acute cerebral ischemia from severe intracranial stenosis in the petrous segment of the left internal carotid artery (LICA)...
June 2018: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/29922350/mind-body-interactions-and-mindfulness-meditation-in-diabetes
#9
REVIEW
Gagan Priya, Sanjay Kalra
Diabetes is associated with significant psychological distress. It is, therefore, important to ensure the physical and emotional as well as psychosocial wellbeing of individuals living with diabetes. Meditation-based strategies have been evaluated for their complementary role in several chronic disorders including depression, anxiety, obesity, hypertension, cardiovascular disease and diabetes. The practice of meditation is associated with reduction in stress and negative emotions and improvements in patient attitude, health-related behaviour and coping skills...
April 2018: European Endocrinology
https://www.readbyqxmd.com/read/29922349/a-retrospective-review-of-the-clinical-characteristics-and-blood-glucose-data-from-cellnovo-system-users-using-data-collected-from-the-cellnovo-online-platform
#10
REVIEW
Olivia Hautier-Suply, Yasmin Friedmann, Julian Shapley
Technological advances have led to innovative insulin delivery systems for patients with type 1 diabetes mellitus. In particular, the combination of miniature engineering and software algorithms contained in continuous subcutaneous insulin infusion (CSII) system pumps provide the user and the healthcare practitioner with an opportunity to review and adjust blood glucose (BG) levels according to system feedback, and to modify or programme their regimen according to their needs. While CSII pumps record a number of data parameters such as BG level, carbohydrate intake, activity and insulin delivered, these data are generally 'locked in' and can only be accessed by uploading to a cloud-based system, thus information is not contemporaneous...
April 2018: European Endocrinology
https://www.readbyqxmd.com/read/29922042/adherence-to-diabetic-self-care-practices-and-its-associated-factors-among-patients-with-type-2-diabetes-in-addis-ababa-ethiopia
#11
Zeleke Bonger, Solomon Shiferaw, Eshetu Zerihun Tariku
Background: Self-care practices in diabetes patients are crucial to keep the illness under control and prevent complications. Effective management of diabetes will be a difficult task without adequate understanding of the existing level of practice related to diabetes self-care. This study is, therefore, aimed at assessing the self-care practice and its associated factors among patients with type 2 diabetes in Tikur Anbessa Specialized Hospital, Ethiopia. Materials and methods: A health facility-based cross-sectional study was conducted among 419 type 2 diabetes patients from March 29, 2013, to May 16, 2013...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29921741/neutrophil-lymphocyte-ratio-and-c-reactive-protein-level-in-patients-with-major-depressive-disorder-before-and-after-pharmacotherapy
#12
A Adhikari, R Dikshit, S Karia, S Sonavane, N Shah, A De Sousa
BACKGROUND: Neutrophil-lymphocyte ratio (NLR) and C-reactive protein (CRP) level are useful biomarkers of inflammation. This study aimed to assess NLR and CRP level in patients with major depressive disorder before and after pharmacotherapy to determine whether NLR or CRP could be used as biomarkers of severity of major depression and whether there was any sex difference. METHODOLOGY: Patients with major depression who received no pharmacotherapy 1 month prior to the study were included...
June 2018: East Asian Archives of Psychiatry: Official Journal of the Hong Kong College of Psychiatrists
https://www.readbyqxmd.com/read/29921358/in-flight-management-of-a-supraventricular-tachycardia-using-telemedicine
#13
Jessica J Voerman, Mary E Hoffe, Sam Surka, Paulo M Alves
BACKGROUND: Supraventricular tachycardia (SVT) is a common presenting arrhythmia in the general population. Cases of SVT presenting during commercial air travel are always challenging as they might be confused with other conditions requiring different treatment strategies. We present a case of an in-flight SVT that was successfully managed using telemedicine support. CASE REPORT: A 33-yr-old woman developed chest pain and dizziness while on an international commercial flight...
July 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29920680/elevated-cerebrospinal-fluid-protein-in-polg-related-epilepsy-diagnostic-and-prognostic-implications
#14
Omar Hikmat, Karin Naess, Martin Engvall, Claus Klingenberg, Magnhild Rasmussen, Chantal M E Tallaksen, Eylert Brodtkorb, Torunn Fiskerstrand, Pirjo Isohanni, Johanna Uusimaa, Niklas Darin, Shamima Rahman, Laurence A Bindoff
OBJECTIVE: Epilepsy is common in individuals with mutations in POLG, the gene encoding the catalytic subunit of the mitochondrial DNA polymerase gamma. Early recognition and aggressive seizure management are crucial for patient survival. Disruption of the blood-brain barrier (BBB) is implicated in various neurological disorders including epilepsy. The aim of this study was to assess whether POLG-related disease is associated with BBB dysfunction and what clinical implications this has for patients...
June 19, 2018: Epilepsia
https://www.readbyqxmd.com/read/29916927/laboratory-tests-for-diagnosis-of-chronic-periprosthetic-joint-infection-can-help-predict-outcomes-of-two-stage-exchange
#15
Maureen K Dwyer, Christopher Damsgaard, Jason Wadibia, Gordon Wong, Damien Lazar, Eric Smith, Carl Talmo, Hany Bedair
BACKGROUND: Although 2-stage exchange arthroplasty is the most effective treatment among available strategies for managing chronic periprosthetic joint infection (PJI), rates of its success vary greatly. The purpose of our study was to examine whether objective measurements collected at the time of the diagnosis of PJI could be used to identify patients at risk of failure of 2-stage exchange. METHODS: We identified 205 patients across 4 institutions who underwent 2-stage exchange arthroplasty for the treatment of PJI following total hip or total knee arthroplasty...
June 20, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29916741/combined-sglt1-and-sglt2-inhibitors-and-their-role-in-diabetes-care
#16
Thomas Danne, Torben Biester, Olga Kordonouri
The sodium-glucose cotransporter type 1 (SGLT1) is the primary transporter for absorption of glucose and galactose in the gastrointestinal tract. Inhibition blunts and delays postprandial glucose (PPG) excursion. Sodium-glucose cotransporter type 2 (SGLT2) is expressed in the kidney, where it reabsorbs 90% of filtered glucose. Thus, a dual SGLT1 and SGLT2 inhibition (compared with selective SGLT2 inhibition) could result in lower PPG and robust A1c reduction even in patients with reduced kidney function. Sotagliflozin is an oral potent dual inhibitor of the insulin-independent SGLT1 and SGLT2...
June 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29916115/reducing-the-number-of-cts-performed-to-monitor-personalized-dosimetry-during-peptide-receptor-radionuclide-therapy-prrt
#17
Alexandre Chicheportiche, Faozi Artoul, Arnon Schwartz, Simona Grozinsky-Glasberg, Amichay Meirovitz, David J Gross, Jeremy Godefroy
BACKGROUND: Peptide receptor radionuclide therapy (PRRT) with [177 Lu]-DOTA-TATE is an effective treatment of neuroendocrine tumors (NETs). After each cycle of treatment, patient dosimetry evaluates the radiation dose to the risk organs, kidneys, and bone marrow, the most radiosensitive tissues. Absorbed doses are calculated from the radioactivity in the blood and from single photon emission computed tomography (SPECT) images corrected by computed tomography (CT) acquired after each course of treatment...
June 19, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/29916092/multiple-hepatic-sclerosing-hemangiomas-a-case-report-and-review-of-the-literature
#18
Kyohei Yugawa, Tomoharu Yoshizumi, Noboru Harada, Takashi Motomura, Norifumi Harimoto, Shinji Itoh, Toru Ikegami, Yuji Soejima, Yoshihiko Maehara
BACKGROUND: Hepatic sclerosing hemangioma, a very rare benign tumor, is characterized by fibrosis and hyalinization occurring in association with degeneration of a hepatic cavernous hemangioma. Such atypical hemangiomas can be diagnosed incorrectly as primary or metastatic malignancies based on imaging characteristics. We present herein a rare case of giant and multiple hepatic sclerosing hemangiomas that are difficult to differentiate from hepatic malignancies and review the relevant literature...
June 19, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29915939/-clinical-management-of-epistaxis
#19
L Uhler, S Knipping
BACKGROUND: Epistaxis is a symptom with many causes, often multifactorial and a frequent cause of consultation in acute medicine. OBJECTIVES: The goal of this study is to analyse the diagnostics used for and therapy of epistaxis, complications and the predictive benefit of laboratory tests. MATERIALS AND METHODS: In this retrospective clinical analysis reports of 720 patients with epistaxis in the period from January 2005 to December 2015 were evaluated...
June 18, 2018: HNO
https://www.readbyqxmd.com/read/29915888/moyamoya-disease-in-pregnancy-a-systematic-review
#20
REVIEW
Georgios A Maragkos, Luis C Ascanio, Kohei Chida, Myles D Boone, Christopher S Ogilvy, Ajith J Thomas, Ekkehard M Kasper
BACKGROUND: Moyamoya disease (MMD) management during pregnancy poses a challenge to health care providers, and recommendations are outdated, vague, and controversial. We conducted a systematic review to investigate and present the available evidence. METHOD: We searched five online databases and bibliographies of relevant published original studies to identify case reports, case series, cohort studies, and reviews reporting on patients diagnosed with MMD before, during, or shortly after pregnancy...
June 19, 2018: Acta Neurochirurgica
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