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https://www.readbyqxmd.com/read/29320596/double-blind-placebo-controlled-evaluation-of-a-novel-skin-lightening-agent
#1
James M Spencer, Julianna Accioly, Neal Kitchen
Melasma remains a troubling problem for physicans and patients alike. It is a chronic irregular, symmetric hyperpigmentation seen most often in women. In this study, a unique combination of ingredients with non-irritating properties was tested for treatment of melasma. In a double blind, placebo controlled, split face trial, 17 patients with melasma were treated on one half of the face, left or right, while the other received placebo control. All patients used sunscreen on both sides. Measurement with a colorimeter (Mexameter) was taken at baseline and after 8 weeks of daily use...
January 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29290184/efficacy-of-intense-pulse-light-therapy-and-tripple-combination-cream-versus-intense-pulse-light-therapy-and-tripple-combination-cream-alone-in-epidermal-melasma-treatment
#2
Nafila Shakeeb, Sahibzada Mahmood Noor, Ghafoor Ullah, Mohammand Majid Paracha
OBJECTIVE: To compare the efficacy of intense pulse light therapy (IPL) and triple combination cream (TCC) versus intense pulse light therapy and triple combination cream alone in epidermal melasma treatment, downgrading MASI score to more than 10. STUDY DESIGN: Randomized controlled trial. PLACE AND DURATION OF STUDY: Dermatology Department, Lady Reading Hospital, Peshawar, from August 2014 to January 2015. METHODOLOGY: Patients of 18-45 years were included in the study with Fitzpatrick skin type II-V...
January 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29286838/patients-self-esteem-before-and-after-chemical-peeling-procedure
#3
Kouris Anargyros, Platsidaki Eftychia, Christodoulou Christos, Efstathiou Vasiliki, Markantoni Vasiliki, Armyra Kaliopi, Potouridou Irene, Rigopoulos Dimitrios, Kontochristopoulos George
INTRODUCTION: Chemical peeling is a safe method, widely used to treat a variety of skin conditions and reduce the aging effects. This study aims to evaluate self-esteem among adolescents who undergo chemical peelings. MATERIAL AND METHODS: One hundred and twenty six patients constituted the study group. Sixty seven individuals had undergone chemical peeling for therapeutic reasons and 59 individuals for cosmetic reasons. To assess patients' self-esteem, the Rosenberg's Self-esteem Scale (RSES) was used before and after treatment...
December 29, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29285880/melasma-a-photoaging-disorder
#4
REVIEW
Thierry Passeron, Mauro Picardo
Melasma is a common hyperpigmentary disorder. The impact on the quality of life of affected individuals is well demonstrated, demanding new therapeutic strategies. However, the treatment of melasma remains highly challenging. Melasma is often considered as the main consequence of female hormone stimulation on a predisposed genetic background. Although these two factors do contribute to this acquired pigmentary disorder, the last decade has revealed several other key players and brought new pieces to the complex puzzle of the pathophysiology of melasma...
December 29, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29234716/physiologic-changes-of-pregnancy-a-review-of-the-literature
#5
REVIEW
Catherine C Motosko, Amy Kalowitz Bieber, Miriam Keltz Pomeranz, Jennifer A Stein, Kathryn J Martires
Throughout pregnancy, the body undergoes a variety of physiologic changes. The cutaneous findings can be most noticeable and often worrisome to both physicians and patients. Obstetricians and dermatologists must be able to differentiate between changes that are benign and those that may be pathologic. Most physicians recognize benign changes that are commonly described in literature such as hyperpigmentation, melasma, striae gravidarum, and telogen effluvium; however, they may be unaware of changes that tend to be less frequently discussed...
December 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/29207818/clinical-efficacy-and-safety-on-combining-20-trichloroacetic-acid-peel-with-topical-5-ascorbic-acid-for-melasma
#6
Surabhi Dayal, Priyadarshini Sahu, Manoj Yadav, V K Jain
Introduction: Trichloroacetic Acid (TCA) is a versatile peeling agent for treatment of melasma. However, Post-Inflammatory Hyperpigmentation (PIH) is reported to be the most common side-effect associated with TCA peel. Topical Ascorbic Acid (AA) due to its effect as antioxidant and tyrosinase inhibitor helps to prevent PIH and maintains the response. Aim: To assess the clinical efficacy, safety and reduction in Melasma Quality of Life (MELASQOL) on combining 20% TCA peel with 5% ascorbic acid cream in epidermal melasma...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29204416/dermoscopy-of-melasma
#7
Sidharth Sonthalia, Abhijeet K Jha, Sonali Langar
No abstract text is available yet for this article.
November 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29204387/pattern-of-skin-diseases-and-occupational-dermatoses-in-veterinarians-and-veterinary-workers-of-kashmir
#8
Sumaya Zeerak, Iffat Hassan, Farhan Rasool, Yasmeen J Bhat, Safia Bashir
Background: Across the globe, skin disorders represent a frequent occupational concern for many health professionals including veterinarians and there is a serious impact of skin diseases on their lives and careers. But little is known about the prevalence and distribution of skin diseases (especially occupational) within this important professional group across Asia, especially India. Materials and Methods: The study was a cross-sectional study carried out over a period of one year in which veterinarians and veterinary workers of Kashmir valley were screened for various skin diseases and occupational dermatoses...
November 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29204386/identification-of-genotypes-and-allelic-frequencies-of-vitamin-d-receptor-gene-polymorphism-taqi-in-egyptian-melasma-patients
#9
Iman Seleit, Ola Ahmed Bakry, Eman Masoud, Shaimaa Nabil
Background: Melasma is a characteristic pattern of facial hyperpigmentation, occurring primarily on the forehead, cheeks, and chin, in a mask-like distribution. The pathogenesis of melasma is not fully understood. Vitamin D plays a role in skin pigmentation. It exerts its effect through vitamin D receptor (VDR), which is expressed in variable cells including normal melanocytes. Aim and Objective: The aim of the current work was to investigate if VDR gene polymorphism (TaqI) confers susceptibility to melasma in Egyptian patients...
November 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29204385/evidence-based-review-grade-of-recommendation-and-suggested-treatment-recommendations-for-melasma
#10
Nilendu Sarma, Sayantani Chakraborty, Shital A Poojary, Sanjay Rathi, Sendhil Kumaran, Balakrishnan Nirmal, Joan Felicita, Rashmi Sarkar, Prashansa Jaiswal, Paschal D'Souza, Nagaraju Donthula, Sumit Sethi, Pallavi Ailawadi, Bebisha Joseph
Treatment of melasma is known to be less satisfactory, often incomplete, and relapse is frequent. Although many treatment options are available, they are either known to be unsafe on long-term use or their long-term safety profile is unknown. Patients often use various drugs, even topical steroid-based preparation without any medical supervision for long period of time, making the skin unsuitable for many of the drugs available. Thus, there has been gross disparity among the treating physician about what drugs and what regimen are best suitable for various categories of melasma patients and in different situations...
November 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29200769/treatment-of-melasma-and-post-inflammatory-hyperpigmentation-by-a-picosecond-755-nm-alexandrite-laser-in-asian-patients
#11
Ye Jin Lee, Ho Jeong Shin, Tai-Kyung Noh, Kwang-Ho Choi, Sung-Eun Chang
The picosecond lasers have shown to effectively treat tattoo pigments that are intractable to previous multiple Q-switched (QS) laser treatments. Therefore we hypothesized that a picosecond laser would show better efficacy with minimal adverse events in the treatment of melasma and post-inflammatory hyperpigmentation (PIH) that are difficult to treat with conventional QS lasers. Two patients with melasma and one patient with PIH were treated with a Picosecond 755-nm Alexandrite Laser (Cyanosure, USA). All patients were Korean with skin type IV and no longer responding to QS laser treatments...
December 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/29186267/incidence-of-skin-diseases-diagnosed-in-a-public-institution-comparison-between-2003-and-2014
#12
Livia Maria Zanardi Miguel, Marilia Formentini Scotton Jorge, Bruna Rocha, Hélio Amante Miot
Epidemiology of diseases is influenced by population socio-demographic circumstances. Therefore it can be modified along the time. There are no studies exploring epidemiological transition in dermatology. This study investigated the incidence of dermatoses in new patients from a Brazilian country town public service in 2003 and 2014. There was a significant increase in the incidence of sexually transmitted diseases, leprosy, melasma, pruritus and hidradenitis suppurativa. However, a prominent reduction in scheduling of appointments for surgeries of benign lesions, drug reactions, urticaria and superficial mycoses was detected...
May 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29186249/tretinoin-peel-a-critical-view
#13
Juliana Mayumi Sumita, Gislaine Ricci Leonardi, Ediléia Bagatin
The tretinoin peel, also known as retinoic acid peel, is a superficial peeling often performed in dermatological clinics in Brazil. The first study on this was published in 2001, by Cuce et al., as a treatment option for melasma. Since then, other studies have reported its applicability with reasonable methodology, although without a consistent scientific background and consensus. Topical tretinoin is used for the treatment of various dermatoses such as acne, melasma, scars, skin aging and non-melanoma skin cancer...
May 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29183309/assessment-of-the-effects-of-skin-microneedling-as-adjuvant-therapy-for-facial-melasma-a-pilot-study
#14
Emerson V A Lima, Mariana Modesto D A Lima, Mauricio Pedreira Paixão, Hélio Amante Miot
BACKGROUND: Melasma is a common chronic and relapsing acquired dyschromia. Skin microneedling was reported resulting sustained long-term improvement of recalcitrant melasma, however, the exact mechanism that promotes this skin lightening is not known. This study aimed to investigate clinical and histologic alterations promoted by skin microneedling in facial melasma. METHODS: Open pilot trial including six women with facial refractory melasma submitted to two sessions of microneedling (1...
November 28, 2017: BMC Dermatology
https://www.readbyqxmd.com/read/29131489/evaluation-of-the-serum-zinc-level-in-adult-patients-with-melasma-is-there-a-relationship-with-serum-zinc-deficiency-and-melasma
#15
Majid Rostami Mogaddam, Nastaran Safavi Ardabili, Manouchehr Iranparvar Alamdari, Nasrollah Maleki, Maryam Aghabalaei Danesh
BACKGROUND: Melasma is a common acquired hypermelanosis of sun-exposed skin, particularly on the face, which presents as symmetric, light- to gray-brown-colored macules and patches. There are several studies of serum zinc levels in cutaneous disorders. So far, no studies have been carried out to assess the serum zinc level in patients with melasma. The aim of this study is to determine the serum zinc level in patients with melasma compared to healthy subjects. MATERIALS AND METHODS: A total of 118 patients with melasma and 118 healthy controls were enrolled in this prospective cross-sectional study...
November 12, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29104723/the-asian-problem-of-frequent-laser-toning-for-melasma
#16
Brian Tian
In recent years, laser toning or laser facial to treat melasma has become increasingly popular in Asia. It is common to see patients undergoing lasers three times a week, or even daily. This is part of a growing trend and is sometimes recommended in the user manuals from laser manufacturers. In our study, we report on 23 Chinese patients who had lasers performed three times a week for two consecutive months, followed by rest. All 23 of them developed bilateral confetti-like hypopigmentation at the end of two months...
July 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29067137/acupuncture-and-cutaneous-medicine-is-it-effective
#17
Mary van den Berg-Wolf, Thomas Burgoon
Background: In China, acupuncture has been used as a form of medical therapy for more than 2500 years. It is a part of traditional medical practice and is used to treat the entire spectrum of human and veterinary disease. Although dermatologic disease has received much less attention in worldwide acupuncture research than pain and musculoskeletal conditions, there is a growing body of evidence suggesting acupuncture's usefulness in this area. Objective: The aim of this article was to review the evidence in the literature regarding the usefulness of acupuncture in managing dermatologic illness...
October 1, 2017: Medical Acupuncture
https://www.readbyqxmd.com/read/29065997/light-emitting-diode-585nm-photomodulation-inhibiting-melanin-synthesis-and-inducing-autophagy-in-human-melanocytes
#18
Li Chen, Zhongyi Xu, Min Jiang, Chengfeng Zhang, Xuan Wang, Leihong Xiang
BACKGROUND: Melasma is a common hyperpigmentation skin disease on face. Light-emitting diode (LED) photomodulation (585nm) is reported to be effective for the treatment of melasma. However, whether and how LED photomodulation would influence melanogenesis of human epidermal melanocytes (HEMs) is unknown. OBJECTIVE: To evaluate the effects of LED photomodulation (585nm) on melanogenesis in HEMs. METHODS: HEMs were irradiated with fluences of 0, 5, 10 and 20J/cm2 585nm LED light...
October 11, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29064976/considerations-when-treating-cosmetic-concerns-in-men-of-color
#19
REVIEW
Olabola Awosika, Cheryl M Burgess, Pearl E Grimes
BACKGROUND: Men of color include a diverse population encompassing individuals with Fitzpatrick skin Types IV through VI. Yet, there is a paucity of data describing the cosmetic concerns of this population. OBJECTIVE: To review the basic science of advantages and disadvantages of skin of color and pathophysiology, incidence, and treatment of disorders of cosmetic concern in men of color. METHODS: A MEDLINE search was performed for publications on sex and racial differences in basic science of skin, common disorders in men of color, and evidence-based treatments...
November 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29057567/q-switched-nd-yag-laser-alone-or-with-modified-jessner-chemical-peeling-for-treatment-of-mixed-melasma-in-dark-skin-types-a-comparative-clinical-histopathological-and-immunohistochemical-study
#20
Fatma Saleh, Noha H Moftah, Eman Abdel-Azim, Marwa G Gharieb
BACKGROUNDS: Treatment of mixed melasma remains challenging. Promising results have been achieved with low-fluence 1064-nm Q-switched Nd-YAG laser; however, multiple sessions are necessary with occurrence of complications especially in dark skin types. So, combination methods may be recommended. AIMS: To compare efficacy of Q-switched Nd-YAG laser alone or with modified Jessner's peel in mixed melasma in dark skin. PATIENTS/METHODS: Nineteen patients with mixed melasma received 6 sessions of laser on left side of face and alternating laser and modified Jessner on right side...
October 22, 2017: Journal of Cosmetic Dermatology
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