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https://www.readbyqxmd.com/read/28645793/biocompatible-polymer-microneedle-for-transdermal-delivery-of-tranexamic-acid
#1
S A Machekposhti, M Soltani, P Najafizadeh, S A Ebrahimi, P Chen
Recently-introduced biocompatible polymeric microneedles offer an efficient method for drug delivery. Tranexamic acid is a novel drug for treating melasma that is administered both locally and orally and inhibits excessive melanin via melanocyte. The tranexamic acid biocompatible polymer microneedle used in this study was fabricated from PVP and methacrylic acid, using the lithography method. The required mechanical strength to pierce skin was attained by optimizing the ratio of PVP to methacrylic acid. Acute dermal toxicity was done, and drug diffusion in skin layers was simulated by calculating the diffusion coefficient of tranexamic acid in interstitial fluid (plasma)...
June 20, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28627081/arginase-2-a-mir-1299-target-enhances-pigmentation-in-melasma-by-reducing-melanosome-degradation-via-senescence-induced-autophagy-inhibition
#2
Nan-Hyung Kim, Soo-Hyun Choi, Nayoung Yi, Tae Ryong Lee, Ai-Young Lee
Expression profiles revealed miR-1299 downregulation concomitant with arginase-2 (ARG2) upregulation in hyperpigmented skin of melasma patients. Opposite regulation of tyrosinase and PMEL17 by miR-1299 and inverse relationship between miR-1299 and ARG2 expression denoted a role of miR-1299 in pigmentation with ARG2 as a miR-1299 target. ARG2 overexpression or knockdown in keratinocytes, the main source of ARG2 in epidermis, positively regulated tyrosinase and PMEL17 protein levels, but not mRNA levels or melanosome transfer...
June 19, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28626485/isolation-and-characterization-of-isofraxidin-7-o-6-o-p-coumaroyl-%C3%AE-glucopyranoside-from-artemisia-capillaris-thunberg-a-novel-nontoxic-hyperpigmentation-agent-that-is-effective-in-vivo
#3
Soon-Ho Yim, Nadia Tabassum, Woong-Hee Kim, Haaglim Cho, Ji-Hyung Lee, Galzad J Batkhuu, Hyun Jung Kim, Won Keun Oh, Da-Woon Jung, Darren R Williams
Abnormalities in skin pigmentation can produce disorders such as albinism or melasma. There is a research need to discover novel compounds that safely and effectively regulate pigmentation. To identify novel modulators of pigmentation, we attempted to purify compounds from a bioactive fraction of the Korean medicinal plant Artemisia capillaris Thunberg. The novel compound isofraxidin 7-O-(6'-O-p-coumaroyl)-β-glucopyranoside (compound 1) was isolated and its pigmentation activity was characterized in mammalian melanocytes...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28607861/a-deceptively-simple-solution-for-refractory-melasma-glycolic-acid-peels-and-hydroquinone-at-home
#4
Takanobu Mashiko, Aiko Oka, Ema Osawa, Isao Koshima
Although various treatment methods for melasma have developed, substantial improvement of the condition is sometimes difficult. We have experientially found that some of refractory melasma caused by daily friction can easily be treated by using a combination of a peeling agent (20% glycolic acid) and a depigmenting agent (5% hydroquinone) twice daily at home. And here, by performing skin biopsies, we revealed the pathological mechanism: hyperkeratosis caused by repeated physical stimulus, which prevents infiltration of topical therapeutic agents, was dramatically reduced by chemical peeling, resulting that the melanin pigments were effectively cleared by topical hydroquinone...
May 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28543966/development-of-a-quantitative-assessment-method-of-pigmentary-skin-disease-using-ultraviolet-optical-imaging
#5
Onseok Lee, Sunup Park, Jaeyoung Kim, Chilhwan Oh
BACKGROUND/PURPOSE: The visual scoring method has been used as a subjective evaluation of pigmentary skin disorders. Severity of pigmentary skin disease, especially melasma, is evaluated using a visual scoring method, the MASI (melasma area severity index). This study differentiates between epidermal and dermal pigmented disease. The study was undertaken to determine methods to quantitatively measure the severity of pigmentary skin disorders under ultraviolet illumination. METHODS: The optical imaging system consists of illumination (white LED, UV-A lamp) and image acquisition (DSLR camera, air cooling CMOS CCD camera)...
May 21, 2017: Skin Research and Technology
https://www.readbyqxmd.com/read/28492049/a-review-of-laser-and-light-therapy-in-melasma
#6
REVIEW
M K Trivedi, F C Yang, B K Cho
Melasma is a dysregulation of the homeostatic mechanisms that control skin pigmentation and excess pigment is produced. Traditional treatment approaches with topical medications and chemical peels are commonly used but due to the refractory and recurrent nature of melasma, patients often seek alternative treatment strategies such as laser and light therapy. Several types of laser and light therapy have been studied in the treatment of melasma. Intense pulsed light, low fluence Q-switched lasers, and non-ablative fractionated lasers are the most common lasers and light treatments that are currently performed...
March 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/28492036/updates-in-the-understanding-and-treatments-of-skin-hair-disorders-in-women-of-color
#7
REVIEW
Christina N Lawson, Jasmine Hollinger, Sumit Sethi, Ife Rodney, Rashmi Sarkar, Ncoza Dlova, Valerie D Callender
Skin of color comprises a diverse and expanding population of individuals. In particular, women of color represent an increasing subset of patients who frequently seek dermatologic care. Acne, melasma, and alopecia are among the most common skin disorders seen in this patient population. Understanding the differences in the basic science of skin and hair is imperative in addressing their unique needs. Despite the paucity of conclusive data on racial and ethnic differences in skin of color, certain biologic differences do exist, which affect the disease presentations of several cutaneous disorders in pigmented skin...
March 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/28489798/efficacy-of-functional-microarray-of-microneedles-combined-with-topical-tranexamic-acid-for-melasma-a-randomized-self-controlled-split-face-study
#8
RANDOMIZED CONTROLLED TRIAL
Yang Xu, Renyan Ma, Juliandri Juliandri, Xiaoyan Wang, Bai Xu, Daguang Wang, Yan Lu, Bingrong Zhou, Dan Luo
To evaluate the efficacy of a functional microarray of microneedles (MNs) plus topical tranexamic acid (TA) for melasma in middle-aged women in China.Thirty female subjects with melasma were enrolled in this study. The left or right side of the face was chosen randomly to be pretreated with a functional microarray of MNs, followed by topical 0.5% TA solution once per week for 12 weeks. The other half-face was the control, treated with a sham device plus topical 0.5% TA solution. At baseline and at weeks 4, 8, and 12 of treatment, clinical (photographic) evaluations and parameters determined by Visia were recorded...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28481450/novel-regulation-of-melanogenesis-by-adiponectin-via-the-ampk-crtc-pathway
#9
Seunghyun Bang, Kwang Hee Won, Hye-Rim Moon, Hanju Yoo, Areum Hong, Youngsup Song, Sung Eun Chang
Several studies observed that adiponectin, an important adipokine that improves glucose metabolism by regulating AMP-activated protein kinase (AMPK) signaling, is dermatologically beneficial. In our recent microarray data, we found that adiponectin expression was lower in lesional skin than in non-lesional skin of melasma patients. Given that AMPK is a key adiponectin signaling mediator, we investigated the role of adiponectin and AICAR, a cell-permeable AMPK activator, in melanogenesis. We herein showed that adiponectin and AICAR downregulated MITF, tyrosinase, TRP-1, and DCT expression and reduced melanin content in normal human and mouse melanocytes...
May 8, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28388246/salicylic-acid-peeling-combined-with-vitamin-c-mesotherapy-versus-salicylic-acid-peeling-alone-in-the-treatment-of-mixed-type-melasma-a-comparative-study
#10
Ali Balevi, Pelin Ustuner, Mustafa Özdemir
INTRODUCTION: Melasma is a distressing condition for both dermatologists and patients. We evaluated the effectiveness of salicylic acid (SA) peel and vitamin C mesotherapy in the treatment of melasma. MATERIALS AND METHODS: Fifty female patients were divided into two groups. All patients were treated with 30% SA peel every two weeks for two months. In addition, after SA peeling Group A was intradermally administered 10 vitamin C on the melasma lesion at 1-cm intervals...
April 7, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28381809/coumestrol-down-regulates-melanin-production-in-melan-a-murine-melanocytes-through-degradation-of-tyrosinase
#11
Jeong Ah Hwang, Nok Hyun Park, Yong Joo Na, Hae Kwang Lee, John Hwan Lee, Yong Jin Kim, Chang Seok Lee
Pigmentation reflects skin darkening caused by melanin production, but excessive melanin synthesis may cause problems, such as melasma, solar lentigo, dark spots, and freckles. Considerable effort has been devoted to alleviating these undesired symptoms through the development of safe and effective depigmenting agents. Coumestrol, a plant-derived natural isoflavone with an estrogen-like structure and actions, is known to have anti-aging ability, but its potential depigmenting efficacy has not been evaluated...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28374042/efficacy-and-safety-of-tranexamic-acid-in-melasma-a-meta-analysis-and-systematic-review
#12
Hyun Jung Kim, Seok Hoon Moon, Sang Hyun Cho, Jeong Deuk Lee, Hei Sung Kim
Tranexamic acid is a novel treatment option for melasma; however, there is no consensus on its use. This systematic review searched major databases for relevant publications to March 2016. Eleven studies with 667 participants were included. Pooled data from tranexamic acid-only observational studies with pre- and post-treatment Melasma Area and Severity Index (MASI) showed a decrease of 1.60 in MASI (95% confidence interval (CI), 1.20-2.00; p < 0.001) after treat-ment with tranexamic acid. The addition of tranexamic acid to routine treatment modalities resulted in a further decrease in MASI of 0...
April 4, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28367263/melasma-associated-with-topical-estrogen-cream
#13
Alyson Snyder, Rachel A Schiechert, Martin N Zaiac
A 47-year-old woman presented with hyperpigmented patches on her upper extremities. The patient had begun using a topical estrogen cream in the affected areas prior to noticing the hyperpigmentation. A diagnosis of melasma secondary to topical estrogen cream was made. While systemic hormones are a well-documented trigger for the development of melasma, this case represents the first report of melasma associated with topical estrogens. Topical estrogens are frequently prescribed to postmenopausal women for skin rejuvenation...
February 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28351480/melasma-treatment-a-novel-approach-using-a-topical-agent-that-contains-an-anti-estrogen-and-a-vascular-endothelial-growth-factor-inhibitor
#14
Philip R Cohen
Melasma is an acquired disorder of pigmentation that presents with asymptomatic symmetric darkening of the face. The pathogenesis of this condition is multifactorial and influenced by several factors including female sex hormones, genetic predisposition and ultraviolet light exposure. The management of melasma is usually directed at more than one of the causative etiologic factors and often incorporates a combination of topical agents, with or without the addition of physical modalities. Estrogen and angiogenesis are significant factors in the etiology of melasma...
April 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28328709/the-clinical-and-histological-effect-of-a-low-fluence-q-switched-1-064-nm-neodymium-yttrium-aluminum-garnet-laser-for-the-treatment-of-melasma-and-solar-lentigo-in-asians-prospective-randomized-and-split-face-comparative-study
#15
Chikako Kaminaka, Fukumi Furukawa, Yuki Yamamoto
BACKGROUND: The low-fluence Q-switched 1,064-nm neodymium:yttrium-aluminum-garnet laser (QSNYL) is popular for melasma treatment among Asians. OBJECTIVE: This study was to evaluate the clinical and histological effects of the low-fluence QSNYL for treatment of melasma and solar lentigo. MATERIALS AND METHODS: In this randomized split-face clinical study, 22 patients with melasma or solar lentigo received low-fluence QSNYL weekly for 10 sessions on one cheek...
March 21, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28328702/commentary-on-combined-jessner-solution-and-trichloroacetic-acid-versus-trichloroacetic-acid-alone-in-the-treatment-of-melasma-in-dark-skinned-patients
#16
Harold J Brody
No abstract text is available yet for this article.
May 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28317176/periorbital-melasma-hierarchical-cluster-analysis-of-clinical-features-in-asian-patients
#17
Y S Jung, J M Bae, B J Kim, J-S Kang, S B Cho
BACKGROUND: Studies have shown melasma lesions to be distributed across the face in centrofacial, malar, and mandibular patterns. Meanwhile, however, melasma lesions of the periorbital area have yet to be thoroughly described. METHODS: We analyzed normal and ultraviolet light-exposed photographs of patients with melasma. The periorbital melasma lesions were measured according to anatomical reference points and a hierarchical cluster analysis was performed. RESULTS: The periorbital melasma lesions showed clinical features of fine and homogenous melasma pigmentation, involving both the upper and lower eyelids that extended to other anatomical sites with a darker and coarser appearance...
March 19, 2017: Skin Research and Technology
https://www.readbyqxmd.com/read/28299301/solution-of-azelaic-acid-20-resorcinol-10-and-phytic-acid-6-versus-glycolic-acid-50-peeling-agent-in-the-treatment-of-female-patients-with-facial-melasma
#18
Gita Faghihi, Azam Taheri, Zabihollah Shahmoradi, Mohammad Ali Nilforoushzadeh
BACKGROUND: Melasma, a common acquired disorder of hyperpigmentation, especially in women, is often resistant to therapy. This study was aimed to evaluate the efficacy and safety of azelaic acid, resorcinol and phytic acid solution in chemical peeling of melasma in comparison to 50% glycolic acid. MATERIALS AND METHODS: This clinical trial was performed, on 42 female patients with bilateral melasma. Severity of melasma was assessed by melasma area and severity index (MASI)...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28283893/tranexamic-acid-in-the-treatment-of-melasma-a-review-of-the-literature
#19
REVIEW
Marina Perper, Ariel Eva Eber, Rachel Fayne, Sebastian Hugo Verne, Robert James Magno, Jessica Cervantes, Mana ALharbi, Ibrahim ALOmair, Abdulkarem Alfuraih, Keyvan Nouri
Melasma is a common acquired pigmentary disorder marked by irregular hyperpigmented macules or patches and most commonly occurs in women of darker skin color. It is a chronic often-relapsing condition that causes negative psychosocial effects in those affected. Current treatments such as hydroquinone, kojic acid, and retinoids, among others, demonstrate variable efficacy and side-effect profiles. We conducted a comprehensive literature review examining the use of tranexamic acid (TA), a well-known anti-fibrinolytic agent, in the treatment of melasma...
June 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28239840/melasma-systematic-review-of-the-systemic-treatments
#20
REVIEW
Linghong Linda Zhou, Akerke Baibergenova
Currently available treatment options for melasma include prevention of UV radiation, topical lightening agents, chemical peels, and light-based and laser therapies. However, none have shown effective and sustained results, with incomplete clearance and frequent recurrences. There has been increasing interest recently in oral medications and dietary supplements in improving melasma. We sought to evaluate the efficacy and safety/tolerability of oral medications and dietary supplements for the treatment of melasma...
February 27, 2017: International Journal of Dermatology
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