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https://www.readbyqxmd.com/read/29131489/evaluation-of-the-serum-zinc-level-in-adult-patients-with-melasma-is-there-a-relationship-with-serum-zinc-deficiency-and-melasma
#1
Majid Rostami Mogaddam, Nastaran Safavi Ardabili, Manouchehr Iranparvar Alamdari, Nasrollah Maleki, Maryam Aghabalaei Danesh
BACKGROUND: Melasma is a common acquired hypermelanosis of sun-exposed skin, particularly on the face, which presents as symmetric, light- to gray-brown-colored macules and patches. There are several studies of serum zinc levels in cutaneous disorders. So far, no studies have been carried out to assess the serum zinc level in patients with melasma. The aim of this study is to determine the serum zinc level in patients with melasma compared to healthy subjects. MATERIALS AND METHODS: A total of 118 patients with melasma and 118 healthy controls were enrolled in this prospective cross-sectional study...
November 12, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29104723/the-asian-problem-of-frequent-laser-toning-for-melasma
#2
Brian Tian
In recent years, laser toning or laser facial to treat melasma has become increasingly popular in Asia. It is common to see patients undergoing lasers three times a week, or even daily. This is part of a growing trend and is sometimes recommended in the user manuals from laser manufacturers. In our study, we report on 23 Chinese patients who had lasers performed three times a week for two consecutive months, followed by rest. All 23 of them developed bilateral confetti-like hypopigmentation at the end of two months...
July 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29067137/acupuncture-and-cutaneous-medicine-is-it-effective
#3
Mary van den Berg-Wolf, Thomas Burgoon
Background: In China, acupuncture has been used as a form of medical therapy for more than 2500 years. It is a part of traditional medical practice and is used to treat the entire spectrum of human and veterinary disease. Although dermatologic disease has received much less attention in worldwide acupuncture research than pain and musculoskeletal conditions, there is a growing body of evidence suggesting acupuncture's usefulness in this area. Objective: The aim of this article was to review the evidence in the literature regarding the usefulness of acupuncture in managing dermatologic illness...
October 1, 2017: Medical Acupuncture
https://www.readbyqxmd.com/read/29065997/light-emitting-diode-585nm-photomodulation-inhibiting-melanin-synthesis-and-inducing-autophagy-in-human-melanocytes
#4
Li Chen, Zhongyi Xu, Min Jiang, Chengfeng Zhang, Xuan Wang, Leihong Xiang
BACKGROUND: Melasma is a common hyperpigmentation skin disease on face. Light-emitting diode (LED) photomodulation (585nm) is reported to be effective for the treatment of melasma. However, whether and how LED photomodulation would influence melanogenesis of human epidermal melanocytes (HEMs) is unknown. OBJECTIVE: To evaluate the effects of LED photomodulation (585nm) on melanogenesis in HEMs. METHODS: HEMs were irradiated with fluences of 0, 5, 10 and 20J/cm(2) 585nm LED light...
October 11, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29064976/considerations-when-treating-cosmetic-concerns-in-men-of-color
#5
REVIEW
Olabola Awosika, Cheryl M Burgess, Pearl E Grimes
BACKGROUND: Men of color include a diverse population encompassing individuals with Fitzpatrick skin Types IV through VI. Yet, there is a paucity of data describing the cosmetic concerns of this population. OBJECTIVE: To review the basic science of advantages and disadvantages of skin of color and pathophysiology, incidence, and treatment of disorders of cosmetic concern in men of color. METHODS: A MEDLINE search was performed for publications on sex and racial differences in basic science of skin, common disorders in men of color, and evidence-based treatments...
November 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29057567/q-switched-nd-yag-laser-alone-or-with-modified-jessner-chemical-peeling-for-treatment-of-mixed-melasma-in-dark-skin-types-a-comparative-clinical-histopathological-and-immunohistochemical-study
#6
Fatma Saleh, Noha H Moftah, Eman Abdel-Azim, Marwa G Gharieb
BACKGROUNDS: Treatment of mixed melasma remains challenging. Promising results have been achieved with low-fluence 1064-nm Q-switched Nd-YAG laser; however, multiple sessions are necessary with occurrence of complications especially in dark skin types. So, combination methods may be recommended. AIMS: To compare efficacy of Q-switched Nd-YAG laser alone or with modified Jessner's peel in mixed melasma in dark skin. PATIENTS/METHODS: Nineteen patients with mixed melasma received 6 sessions of laser on left side of face and alternating laser and modified Jessner on right side...
October 22, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29027510/comparing-the-efficacy-of-topical-hydroquinone-2-vs-intradermal-tranexamic-acid-microinjections-in-treating-melasma-a-split-face-controlled-trial
#7
Nasrin Saki, Mohammad Darayesh, Alireza Heiran
INTRODUCTION: Melasma is a benign, acquired, and chronic hypermelanosis. Topical hydroquinone (HQ) is a conventional choice to treat melasma. Tranexamic acid (TA) is a relatively new brightening agent that interferes with keratinocyte- melanocyte interactions. The aim of the present study was to compare the efficacy and safety of TA intradermal injections with HQ in treating melasma. MATERIALS AND METHODS: In this split-face controlled trial, thirty-seven patients were randomized to receive three monthly sessions of TA intradermal injections either on the right or the left side of their face, and topical HQ once a night for three months on the other side...
October 13, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29020467/effects-of-fractional-picosecond-1-064%C3%A2-nm-laser-for-the-treatment-of-dermal-and-mixed-type-melasma
#8
Thep Chalermchai, Paisal Rummaneethorn
BACKGROUND: Picosecond laser is a novel modality for pigmented skin disorders with extremely short pulse duration. Little is known about the effects of picosecond laser in melasma. OBJECTIVE: This study aimed to investigate the efficacy of fractional picosecond 1,064 nm laser in melasma treatment. STUDY DESIGN: A prospective, randomized, assessor-blinded, intra-individual split face comparative study. METHODS: Female subjects with melasma were enrolled and received fractional picosecond 1,064 nm laser plus 4% hydroquinone cream on one randomly-assigned side of the face; results were compared to use of hydroquinone cream only on the contralateral side...
October 11, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28990515/recent-advances-and-perspectives-in-liposomes-for-cutaneous-drug-delivery
#9
Amanda C Caritá, Josimar O Eloy, Marlus Chorilli, Robert J Lee, Gislaine Ricci Leonardi
The cutaneous route is attractive for the delivery of drugs in the treatment of a wide variety of diseases. However the stratum corneum (SC) is an effective barrier that hampers skin penetration. Within this context, liposomes emerge as a potential carrier for improving topical delivery of therapeutic agents. In this review, we aimed to discuss key aspects for the topical delivery by drug-loaded liposomes. Phospholipid type and phase transition temperature have been shown to affect liposomal topical delivery...
October 9, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28987494/randomized-placebo-controlled-double-blind-study-of-oral-tranexamic-acid-in-the-treatment-of-moderate-to-severe-melasma
#10
Eunice Del Rosario, Stephanie Florez-Pollack, Lucio Zapata, Katia Hernandez, Andrea Tovar-Garza, Michelle Rodrigues, Linda S Hynan, Amit G Pandya
BACKGROUND: Melasma is a common pigmentary disorder that is often difficult to treat. Tranexamic acid (TA) has emerged as a promising treatment for melasma; however, few controlled studies exist. OBJECTIVE: To determine the efficacy of oral TA in patients with moderate to severe melasma METHODS: Patients with moderate to severe melasma were treated with 250 mg of TA or placebo capsules twice daily for 3 months and sunscreen followed by 3 months of treatment with sunscreen only...
October 4, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28979657/nonablative-fractional-laser-resurfacing-in-skin-of-color-evidence-based-review
#11
REVIEW
Shivani B Kaushik, Andrew F Alexis
Background: Nonablative laser resurfacing represents one of the major advances in procedural dermatology over the past decade. However, its use in darker skin types is limited by safety concerns and a relative lack of available data. Aim: To provide evidence-based recommendations for the use of fractional lasers in darker skin types. Evidence review: A broad literature search of PubMed/Medline database was conducted in April 2016 using the term fractional lasers. A free text search of keywords including fractional resurfacing, nonablative lasers, skin type, skin of color, ethnic skin, Fitzpatrick skin type, Asian skin, African Americans, Afro-Caribbean, and Hispanics was also executed...
June 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28979653/topical-anti-estrogen-therapy-to-treat-melasma
#12
Philip R Cohen
No abstract text is available yet for this article.
June 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28940653/the-clinicoaetiological-hormonal-and-histopathological-characteristics-of-melasma-in-men
#13
S Handa, D De, G Khullar, B D Radotra, N Sachdeva
BACKGROUND: Melasma is relatively uncommon in males, and there is a paucity of data on male melasma, including its clinical pattern, triggering factors, endocrine profile and histopathological findings. AIM: To characterize the clinical findings and aetiological factors, including hormonal and histopathological features, of male melasma. METHODS: Male patients with melasma and age- and sex-matched healthy controls (HCs) were recruited. Demographic profile, risk factors, clinical pattern and Wood lamp findings of patients were recorded...
September 22, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28912936/combination-of-q-switched-nd-yag-and-fractional-erbium-yag-lasers-in-treatment-of-melasma-a-randomized-controlled-clinical-trial
#14
Shiva Alavi, Ehsan Abolhasani, Sharin Asadi, Mohammadali Nilforoushzadeh
Introduction: Ablative and nonablative lasers have been used to treat melasma. We aimed to assess and compare the combining Q-switched Nd:YAG laser (QSNYL) and fractional erbium:YAG laser (FEYL) with QSNYL alone in treatment of melasma. Methods: This randomized controlled clinical trial was performed in our Research Center during 2013-2014. Women with melasma and without a history of keloid formation, hypersensitivity to hydroquinone, or pigmentary changes due to laser therapy were randomly allocated to receive four sessions of either QSNYL-FEYL combination or QSNYL alone...
2017: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/28911859/recent-development-of-signaling-pathways-inhibitors-of-melanogenesis
#15
REVIEW
Thanigaimalai Pillaiyar, Manoj Manickam, Sang-Hun Jung
Human skin, eye and hair color rely on the production of melanin, depending on its quantity, quality, and distribution, Melanin plays a monumental role in protecting the skin against the harmful effect of ultraviolet radiation and oxidative stress from various environmental pollutants. However, an excessive production of melanin causes serious dermatological problems such as freckles, solar lentigo (age spots), melasma, as well as cancer. Hence, the regulation of melanin production is important for controlling the hyper-pigmentation...
December 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28906574/efficacy-and-safety-of-a-novel-picosecond-laser-using-combination-of-1%C3%A2-064-and-595%C3%A2-nm-on-patients-with-melasma-a-prospective-randomized-multicenter-split-face-2-hydroquinone-cream-controlled-clinical-trial
#16
Young-Jun Choi, Jae-Hui Nam, Jung Yup Kim, Joon Hong Min, Kui Young Park, Eun Jung Ko, Beom Joon Kim, Won-Serk Kim
BACKGROUND AND OBJECTIVES: Melasma is a common acquired, chronic hypermelanosis and still remains a therapeutic challenge. The low-fluence 1 064 nm Q-switched Nd:YAG laser is the most widely used for the treatment of moderate to severe melasma in Asia. Recently, the picosecond laser has been introduced for various pigmentary disorders such as melasma. We evaluated the efficacy and safety of a picosecond laser with dual-wavelengths (1 064 and 595 nm) and topical 2% hydroquinone (HQ) combination therapy on patients with melasma, and compared results with those obtained with 2% HQ alone...
September 14, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28902026/chemical-peels-indications-and-special-considerations-for-the-male-patient
#17
REVIEW
Jeave Reserva, Amanda Champlain, Seaver L Soon, Rebecca Tung
BACKGROUND: Chemical peels are a mainstay of aesthetic medicine and an increasingly popular cosmetic procedure performed in men. OBJECTIVE: To review the indications for chemical peels with an emphasis on performing this procedure in male patients. MATERIALS AND METHODS: Review of the English PubMed/MEDLINE literature and specialty texts in cosmetic dermatology, oculoplastic, and facial aesthetic surgery regarding sex-specific use of chemical peels in men...
November 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28889340/hypothyroidism-in-the-arnolfini-portrait-1434-by-jan-van-eyck-1390-1441
#18
H Ashrafian
BACKGROUND: The Arnolfini portrait painted by Jan van Eyck in 1434 remains one of the most puzzling yet alluring paintings of prerenaissance western art. PURPOSE: The painting is renowned for its exactitude in brush strokes, textures and the distinctive morphology of the main character Arnolfini. The nature of these requires pathological consideration. METHODS: Diagnostic and pathological analysis of the painting. RESULTS: A number of pathological abnormalities are noted in the face of the main character including loss of outer third of the eyebrow (Sign of Hertoghe), bilateral ptosis and melasma of the forehead...
September 9, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28857939/melasma-treatment-with-combined-chemical-peels-and-novel-topical-agent-containing-an-anti-estrogen-and-a-vascular-endothelial-growth-factor-inhibitor
#19
Philip R Cohen
No abstract text is available yet for this article.
August 28, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28834124/black-peel-in-facial-dermatoses
#20
Ebtisam Elghblawi
BACKGROUND: Melasma (facial dermatoses) is an acquired chronic disorder of hyperpigmentation over sun exposed parts and continues to be a therapeutic challenge due to the presence of melanin at varying depths in the epidermis and dermis, and many researchers are working hard to find a solution. The main culprit to remain is direct sun exposure, with other factors like drugs, genetic predisposition, thyroid abnormalities, pregnancy, phototoxic and photoallergic cosmetics. Melasma continues to have a remarkable impact on the well-being of affected patients causing deep psychological and social anguish, and with the expansion of cosmetic dermatology globally, treatments that are successful against skin diseases and boost beauty without prolonged recovery periods, or exposing patients to the risks of surgery, are increasingly recognised and acknowledged...
August 22, 2017: Journal of Cosmetic Dermatology
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