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https://www.readbyqxmd.com/read/28940653/the-clinicoaetiological-hormonal-and-histopathological-characteristics-of-melasma-in-men
#1
S Handa, D De, G Khullar, B D Radotra, N Sachdeva
BACKGROUND: Melasma is relatively uncommon in males, and there is a paucity of data on male melasma, including its clinical pattern, triggering factors, endocrine profile and histopathological findings. AIM: To characterize the clinical findings and aetiological factors, including hormonal and histopathological features, of male melasma. METHODS: Male patients with melasma and age- and sex-matched healthy controls (HCs) were recruited. Demographic profile, risk factors, clinical pattern and Wood lamp findings of patients were recorded...
September 22, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28912936/combination-of-q-switched-nd-yag-and-fractional-erbium-yag-lasers-in-treatment-of-melasma-a-randomized-controlled-clinical-trial
#2
Shiva Alavi, Ehsan Abolhasani, Sharin Asadi, Mohammadali Nilforoushzadeh
Introduction: Ablative and nonablative lasers have been used to treat melasma. We aimed to assess and compare the combining Q-switched Nd:YAG laser (QSNYL) and fractional erbium:YAG laser (FEYL) with QSNYL alone in treatment of melasma. Methods: This randomized controlled clinical trial was performed in our Research Center during 2013-2014. Women with melasma and without a history of keloid formation, hypersensitivity to hydroquinone, or pigmentary changes due to laser therapy were randomly allocated to receive four sessions of either QSNYL-FEYL combination or QSNYL alone...
2017: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/28911859/recent-development-of-signaling-pathways-inhibitors-of-melanogenesis
#3
REVIEW
Thanigaimalai Pillaiyar, Manoj Manickam, Sang-Hun Jung
Human skin, eye and hair color rely on the production of melanin, depending on its quantity, quality, and distribution, Melanin plays a monumental role in protecting the skin against the harmful effect of ultraviolet radiation and oxidative stress from various environmental pollutants. However, an excessive production of melanin causes serious dermatological problems such as freckles, solar lentigo (age spots), melasma, as well as cancer. Hence, the regulation of melanin production is important for controlling the hyper-pigmentation...
September 12, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28906574/efficacy-and-safety-of-a-novel-picosecond-laser-using-combination-of-1%C3%A2-064-and-595%C3%A2-nm-on-patients-with-melasma-a-prospective-randomized-multicenter-split-face-2-hydroquinone-cream-controlled-clinical-trial
#4
Young-Jun Choi, Jae-Hui Nam, Jung Yup Kim, Joon Hong Min, Kui Young Park, Eun Jung Ko, Beom Joon Kim, Won-Serk Kim
BACKGROUND AND OBJECTIVES: Melasma is a common acquired, chronic hypermelanosis and still remains a therapeutic challenge. The low-fluence 1 064 nm Q-switched Nd:YAG laser is the most widely used for the treatment of moderate to severe melasma in Asia. Recently, the picosecond laser has been introduced for various pigmentary disorders such as melasma. We evaluated the efficacy and safety of a picosecond laser with dual-wavelengths (1 064 and 595 nm) and topical 2% hydroquinone (HQ) combination therapy on patients with melasma, and compared results with those obtained with 2% HQ alone...
September 14, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28902026/chemical-peels-indications-and-special-considerations-for-the-male-patient
#5
Jeave Reserva, Amanda Champlain, Seaver L Soon, Rebecca Tung
BACKGROUND: Chemical peels are a mainstay of aesthetic medicine and an increasingly popular cosmetic procedure performed in men. OBJECTIVE: To review the indications for chemical peels with an emphasis on performing this procedure in male patients. MATERIALS AND METHODS: Review of the English PubMed/MEDLINE literature and specialty texts in cosmetic dermatology, oculoplastic, and facial aesthetic surgery regarding sex-specific use of chemical peels in men...
September 4, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28889340/hypothyroidism-in-the-arnolfini-portrait-1434-by-jan-van-eyck-1390-1441
#6
H Ashrafian
BACKGROUND: The Arnolfini portrait painted by Jan van Eyck in 1434 remains one of the most puzzling yet alluring paintings of prerenaissance western art. PURPOSE: The painting is renowned for its exactitude in brush strokes, textures and the distinctive morphology of the main character Arnolfini. The nature of these requires pathological consideration. METHODS: Diagnostic and pathological analysis of the painting. RESULTS: A number of pathological abnormalities are noted in the face of the main character including loss of outer third of the eyebrow (Sign of Hertoghe), bilateral ptosis and melasma of the forehead...
September 9, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28857939/melasma-treatment-with-combined-chemical-peels-and-novel-topical-agent-containing-an-anti-estrogen-and-a-vascular-endothelial-growth-factor-inhibitor
#7
Philip R Cohen
No abstract text is available yet for this article.
August 28, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28834124/black-peel-in-facial-dermatoses
#8
Ebtisam Elghblawi
BACKGROUND: Melasma (facial dermatoses) is an acquired chronic disorder of hyperpigmentation over sun exposed parts and continues to be a therapeutic challenge due to the presence of melanin at varying depths in the epidermis and dermis, and many researchers are working hard to find a solution. The main culprit to remain is direct sun exposure, with other factors like drugs, genetic predisposition, thyroid abnormalities, pregnancy, phototoxic and photoallergic cosmetics. Melasma continues to have a remarkable impact on the well-being of affected patients causing deep psychological and social anguish, and with the expansion of cosmetic dermatology globally, treatments that are successful against skin diseases and boost beauty without prolonged recovery periods, or exposing patients to the risks of surgery, are increasingly recognised and acknowledged...
August 22, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28831422/laser-treatment-of-medical-skin-disease-in-women
#9
REVIEW
C LaRosa, A Chiaravalloti, S Jinna, W Berger, J Finch
Laser treatment is a relatively new and increasingly popular modality for the treatment of many dermatologic conditions. A number of conditions that predominantly occur in women and that have a paucity of effective treatments include rosacea, connective tissue disease, melasma, nevus of Ota, lichen sclerosus (LS), notalgia paresthetica and macular amyloidosis, and syringomas. Laser therapy is an important option for the treatment of patients with these conditions. This article will review the body of literature that exists for the laser treatment of women with these medical conditions...
September 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/28825660/protocatechuic-acid-from-pear-inhibits-melanogenesis-in-melanoma-cells
#10
Xuan T Truong, Seo-Hee Park, Yu-Geon Lee, Hang Yeon Jeong, Jae-Hak Moon, Tae-Il Jeon
Despite the critical role of melanin in the protection of skin against UV radiation, excess production of melanin can lead to hyperpigmentation and skin cancer. Pear fruits are often used in traditional medicine for the treatment of melasma; therefore, we investigated the effects of pear extract (PE) and its component, protocatechuic acid (PCA), on melanogenesis in mouse melanoma cells. We found that PE and PCA significantly suppressed melanin content and cellular tyrosinase activity through a decrease in the expression of melanogenic enzymes and microphthalmia-associated transcription factor (Mitf) in α-melanocyte stimulating hormone-stimulated mouse melanoma cells...
August 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28796657/microneedling-a-review-and-practical-guide
#11
Tina S Alster, Paul M Graham
BACKGROUND: Microneedling is a relatively new treatment option in dermatology and has been touted for a broad range of applications including skin rejuvenation, acne scarring, rhytides, surgical scars, dyschromia, melasma, enlarged pores, and transdermal drug delivery. The significant increase in minimally invasive procedures that has been reported over the past several years suggest that microneedling may occupy a specific niche for patients who desire measurable clinical results from treatments with little to no recovery...
August 7, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28790335/involvement-of-transient-receptor-potential-cation-channel-member-a1-activation-in-the-irritation-and-pain-response-elicited-by-skin-lightening-reagent-hydroquinone
#12
Yan Tai, Chuan Wang, Zhihua Wang, Yi Liang, Junying Du, Dongwei He, Xiaoyan Fan, Sven-Eric Jordt, Boyi Liu
Hydroquinone (HQ) is one of the most frequently used and effective skin-lightening products to treat skin hyperpigmentation disorders, including postinflammatory hyperpigmentation, melasma and solar lentigines. HQ is also widely used in cosmetic products for skin whitening. However, HQ treatment can evoke substantial skin irritation, a side effect that remains poorly understood. Here we demonstrate that HQ is an activator of the peripheral irritant receptor transient receptor potential (TRP) cation channel member A1 (TRPA1)...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28748406/therapeutic-effects-of-topical-tranexamic-acid-in-comparison-with-hydroquinone-in-treatment-of-women-with-melasma
#13
Najmolsadat Atefi, Behzad Dalvand, Mahammadreza Ghassemi, Golnaz Mehran, Amir Heydarian
INTRODUCTION: Few studies have focused on therapeutic as well as side effects of tranexamic acid (TXA) as a topical drug compared to other topical drugs in treating melasma. The present study aimed to assess and compare the beneficial therapeutic effects and also side effects of local TXA in comparison with hydroquinone in treating women with melasma. METHODS: This randomized double-blinded clinical trial was performed on 60 women who suffered from melasma and were referred to the skin disorders clinic at the Rasoul-e-Akram hospital in Tehran in 2015...
July 26, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28726212/melasma-an-up-to-date-comprehensive-review
#14
REVIEW
Oluwatobi A Ogbechie-Godec, Nada Elbuluk
Melasma is a common acquired condition of symmetric hyperpigmentation, typically occurring on the face, with higher prevalence in females and darker skin types. Multiple etiologies, including light exposure, hormonal influences, and family history, have been implicated in the pathogenesis of this disorder. Overall prevalence ranges widely at 1-50%, since values are typically calculated within a specific ethnic population within a geographic region. Histologically, melasma can display increased epidermal and/or dermal pigmentation, enlarged melanocytes, increased melanosomes, solar elastosis, dermal blood vessels, and, occasionally, perivascular lymphohistiocytic infiltrates...
July 19, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28711101/subclinical-melasma-determining-disease-extent
#15
Stephen A Wirya, Mayra B de Castro Maymone, Rafael Widjajahakim, Neelam A Vashi
No abstract text is available yet for this article.
August 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28695326/anti-melanogenic-effect-of-gomisin-n-from-schisandra-chinensis-turcz-baillon-schisandraceae-in-melanoma-cells
#16
JungNo Lee, Hwa Sun Ryu, Jae-Moon Kim, Tae-Hwa Jung, Sung-Min Park, Yong-Moon Lee
Overproduction and accumulation of melanin in the skin can lead to pigmentation disorders, such as freckles and melasma. Many researchers are studying the regulation of melanogenesis in the skin with the aim of developing whitening cosmetics. In this study, bioactivity-guided separation of the hexane fraction of Schisandra chinensis (Turcz.) Baillon extract yielded five major compounds, β-chamigrenal, α-ylangenol, gomisin N, gomisin A, and schisandrin. The structures were identified by using (1)H-NMR and (13)C-NMR spectroscopy and comparing the spectral data with published data...
July 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28690124/microneedling-where-do-we-stand-now-a-systematic-review-of-the-literature
#17
REVIEW
Lisa Ramaut, Henk Hoeksema, Ali Pirayesh, Filip Stillaert, Stan Monstrey
BACKGROUND: Patients who suffer from scars or wrinkles have several therapeutic options to improve the appearance of their skin. The available treatment modalities that provide desirable results are often overtly invasive and entail a risk of undesirable adverse effects. Microneedling has recently emerged as a non-ablative alternative for treating patients who are concerned with the aesthetic changes that result from injury, disease or ageing. OBJECTIVE: This review aims to evaluate the current evidence in the literature on microneedling...
June 17, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28681382/role-of-oxidative-stress-in-melasma-a-prospective-study-on-serum-and-blood-markers-of-oxidative-stress-in-melasma-patients
#18
Vikrant Choubey, Rashmi Sarkar, Vijay Garg, Smita Kaushik, Sneha Ghunawat, Sidharth Sonthalia
BACKGROUND: Melasma is a common pigmentary disorder presenting in the dermatological clinic. Many factors have been implicated in the pathogenesis, however, the cause still remains elusive. Recently the effect of oxidative damage has been proposed in the etiopathogenesis of melasma. This study was undertaken to evaluate the role of oxidative stress in patients with melasma. MATERIAL AND METHODS: Fifty patients with melasma, age 18 years of age and older, and an equal number of age and sex-matched controls were included in the study...
July 5, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28678558/efficacy-of-cysteamine-cream-in-the-treatment-of-epidermal-melasma-evaluating-by-dermacatch-as-a-new-measurement-method-a-randomized-double-blind-placebo-controlled-study
#19
Susan Farshi, Parvin Mansouri, Behrooz Kasraee
BACKGROUND: Melasma is a difficult-to-treat hyperpigmentary disorder. Very few studies have been performed regarding the efficacy of cysteamine in the treatment of melasma. OBJECTIVE: To determine the efficacy of cysteamine cream in the treatment of patients with epidermal melasma using Dermacatch(®) as a more accurate skin colorimetric measurement tool. METHODS: Participating patients (n = 40) received either placebo (n = 20) or cysteamine cream (n = 20) in a double-blind placebo controlled study...
July 5, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28673563/the-role-of-oligomenorrhea-in-melasma
#20
Marjan Mahjour, Arash Khoushabi, Zohre Feyzabadi
Melasma is a facial hyperpigmentation in the upper lips, cheeks, forehead and chin. It is mostly seen in women. Melasma treatments include topical methods that are not only costly, but also temporary. Melasma recurs shortly after cessation of the treatment. Considering the relationship between melasma and elevated estrogen levels in patients with oligomenorrhea, systemic anti-estrogen therapies are not used for melasma. In this study, by searching in the scientific databases such as Scopus, Pubmed and the authentic books of traditional medicine such as the Canon of medicine, melasma treatment was evaluated based on oligomenorrhea systemic therapy...
July 2017: Medical Hypotheses
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