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https://www.readbyqxmd.com/read/27930379/reliability-validity-and-sensitivity-to-change-overtime-of-the-modified-melasma-area-and-severity-index-score
#1
Doaa A E Abou-Taleb, Ahmed K Ibrahim, Eman M K Youssef, Alaa E A Moubasher
BACKGROUND: The new modified Melasma Area and Severity Index (mMASI) score, the recently used outcome measure for melasma, has not been tested to determine its sensitivity to change in melasma. OBJECTIVE: To determine the reliability, validity, and sensitivity to change overtime of the mMASI score in assessment of the severity of melasma. METHODS: Pearson correlation, Cronbach alpha, and intraclass correlation coefficient were calculated to assess the reliability of the mMASI score...
December 2, 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27926637/pigmentation-and-pregnancy-knowing-what-is-normal
#2
Amy Kalowitz Bieber, Kathryn J Martires, Jennifer A Stein, Jane M Grant-Kels, Marcia S Driscoll, Miriam Keltz Pomeranz
Changes in melanocytic nevi during pregnancy are frequently attributed to the new hormonal milieu and are dismissed without concern for malignancy. Recent studies suggest that pregnancy itself does not induce significant change in nevi, and delays in the assessment of changing moles may contribute to the often more advanced nature of melanomas diagnosed during or soon after pregnancy. Nevi on the breasts and abdomen can grow as a result of skin expansion, but studies have found no significant changes in nevi located in more stable areas such as the back or lower extremities...
December 2, 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27918005/a-review-of-melasma-treatment-focusing-on-laser-and-light-devices
#3
Janet Y Li, Elizabeth Rc Geddes, Deanne M Robinson, Paul M Friedman
Melasma is a pigmentary disorder of unclear etiology with numerous treatment options and high recurrence rates. Laser and light therapies may be utilized cautiously as second- or third-line options for recalcitrant melasma, but low-energy settings are preferred due to the risk of postinflammatory hyperpigmentation and melasma stimulation. Commonly used lasers include the low-fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet laser, nonablative fractionated lasers, and intense pulsed light. Strict sun protection, concomitant use of bleaching agents, and maintenance treatments are necessary...
December 2016: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/27911217/laser-toning-for-melasma-a-single-center-experience-with-38-970-cases
#4
Brian Tian
Melasma is a common pigmentation in Asian women. Lasers have been used to lighten melasma, although with variable outcomes and complications. In Asia, laser toning is a common technique used to safely lighten melasma. However, no large studies have been performed to validate efficacy. In our study, we demonstrate that in 38,970 Asian women, at least 35,890 patients (92.1%) had noticeable to excellent improvement in their melasma.
December 2, 2016: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/27911108/comparative-study-of-dual-pulsed-1-064-nm-q-switched-nd-yag-laser-and-single-pulsed-1-064-nm-q-switched-nd-yag-laser-by-using-zebrafish-model-and-prospective-split-face-analysis-of-facial-melasma
#5
Hee Won Jang, Seung Hyun Chun, Hae Chul Park, Hwa Jung Ryu, Il-Hwan Kim
BACKGROUND: Recently dual-pulsed low-fluence 1,064 nm Q-switched Nd:YAG (QSNY) laser has been developed for reducing complication during melasma treatment. OBJECTIVE: Comparison of the efficacy and safety between dual-pulsed mode and single-pulsed mode for the treatment of melasma. MATERIALS AND METHODS: In preclinical study, adult zebrafish were irradiated with dual-pulsed and single-pulsed mode. Changes of melanophore and cell death were assessed...
December 2, 2016: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/27904270/morphologic-changes-of-zebrafish-melanophore-after-intense-pulsed-light-and-q-switched-nd-yag-laser-irradiation
#6
Hwa Jung Ryu, Ji Min Lee, Hee Won Jang, Hae Chul Park, Im Joo Rhyu, Il-Hwan Kim
BACKGROUND: Recently, the pulse-in-pulse mode of intense pulsed light (IPL) has been used increasingly for the treatment of melasma. OBJECTIVE: To observe the morphologic changes in the melanophore in adult zebrafish after irradiation with conventional and pulse-in-pulse IPL and Q-switched Nd:YAG (QSNY) laser. METHODS: Adult zebrafish were irradiated with conventional and pulse-in-pulse mode of IPL. The conditions for conventional IPL were 3 mJ/cm(2), 560 nm filter, and pulse widths of 7, 20, and 35 msec...
December 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27902522/the-effect-of-topical-use-of-petroselinum-crispum-parsley-versus-that-of-hydroquinone-cream-on-reduction-of-epidermal-melasma-a-randomized-clinical-trial
#7
Shahla Khosravan, Ali Alami, Hossein Mohammadzadeh-Moghadam, Vahide Ramezani
Melasma disfigures the skin and thus influences people's self-image and self-concept. Therefore, melasma influences emotional and psychosocial health in addition to physical health. This clinical trial was performed to assess the effect of the topical use of Petroselinum crispum (parsley) on reduction of the severity of epidermal melasma.
January 2017: Holistic Nursing Practice
https://www.readbyqxmd.com/read/27854332/fractional-co%C3%A2-laser-pretreatment-facilitates-transdermal-delivery-of-two-vitamin-c-derivatives
#8
Chien-Yu Hsiao, Hsin-Ching Sung, Sindy Hu, Yau-Li Huang, Chun-Hsun Huang
BACKGROUND: Topical vitamin C derivatives have been used to treat melasma and used as a skin whitener. The aim of this study was to compare skin histology and permeation of l-ascorbic acid 2-phosphate sesquimagnesium salt (MAP-1) and magnesium l-ascorbic acid-2-phosphate (MAP-2) after fractional CO₂ laser pretreatment. METHODS: The effect of fractional laser treatment on porcine skin was examined by scanning electron microscopy and confocal laser scanning electron microscopy...
November 16, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27762489/comparison-of-the-therapeutic-efficacy-and-safety-of-combined-oral-tranexamic-acid-and-topical-hydroquinone-4-treatment-vs-topical-hydroquinone-4-alone-in-melasma-a-parallel-group-assessor-and-analyst-blinded-randomized-controlled-trial-with-a-short-term-follow
#9
Vahideh Lajevardi, Afsaneh Ghayoumi, Robabeh Abedini, Hamed Hosseini, Azadeh Goodarzi, Zahra Akbari, Kosar Hedayat
BACKGROUND: Melasma's high prevalence and profound psychological impact on patients necessitate efficacious, economical, and safe therapeutic interventions. Adjunctive therapies such as tranexamic acid (TA) can enhance the therapeutic effect of standard treatments like hydroquinone 4% cream (HQ). OBJECTIVE: To conduct an assessor- and analyst-blinded, parallel, superiority, randomized controlled trial to compare the clinical efficacy and safety of oral TA plus HQ vs...
October 20, 2016: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/27756961/melasma-a-rare-adverse-effect-of-clomipramine
#10
Sujita Kumar Kar
Melasma is a hyperpigmented dermatological condition common in females. Drugs such as steroids, cosmetics, and photosensitizing agents are known to cause melasma. We report here a case of an adult male with obsessive-compulsive disorder, receiving clomipramine, who developed melasma.
July 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/27755171/microneedling-a-comprehensive-review
#11
Angela Hou, Brandon Cohen, Adele Haimovic, Nada Elbuluk
BACKGROUND: Microneedling is a minimally invasive procedure that uses fine needles to puncture the epidermis. The microwounds created stimulate the release of growth factors and induce collagen production. The epidermis remains relatively intact, therefore helping to limit adverse events. The indications for microneedling therapy have grown significantly, and it is becoming a more widely used treatment in dermatology. OBJECTIVE: A comprehensive review of microneedling in human subjects and its applications in dermatology...
October 13, 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27738425/profile-of-skin-disorders-in-unreached-hilly-areas-of-north-india
#12
Deepak Dimri, Venkatashiva Reddy B, Amit Kumar Singh
Background. The pattern of skin morbidity in an area depends on climate, geography, socioeconomic status, nutrition, genetics, and habits of the community. Objective. The objective of the present study was to describe the morbidity profile of patients attending dermatology outpatient department in a tertiary care centre of Garhwal hills, North India. Methodology. This is a record based study carried out using the morbidity registers. Patient details, diagnosis, and treatment provided by physicians were documented in the morbidity register...
2016: Dermatology Research and Practice
https://www.readbyqxmd.com/read/27712039/efficacy-of-topical-flutamide-in-the-treatment-of-melasma
#13
Nooshin Bagherani
No abstract text is available yet for this article.
September 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/27702910/reversible-facial-hyperpigmentation-associated-with-vitamin-b12-deficiency
#14
Leeda Tayem, Noureddine Litaiem, Mariem Jones, Faten Zeglaoui
Vitamin B12 (cobalamin) deficiency is common in developing countries. Its dermatologic manifestations include hair and nail changes and glossitis. Cases of generalized hyperpigmentation associated with vitamin B12 deficiency have rarely been reported. Localized hyperpigmentation is less frequently described, affecting palms, soles, and flexural areas. We report a rare case of reversible melasma-like cutaneous hyperpigmentation associated with pernicious anemia and discuss the possible mechanisms of this association...
October 4, 2016: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/27696509/inhibitory-effect-of-660-nm-led-on-melanin-synthesis-in-in-vitro-and-in-vivo
#15
Chang Taek Oh, Tae-Rin Kwon, Eun Ja Choi, Soon Re Kim, Joon Seok, Seog Kyun Mun, Kwang Ho Yoo, Yeon Shik Choi, Sun Young Choi, Beom Joon Kim
BACKGROUND: Skin hyperpigmentary disorders including postinflammatory hyperpigmentation, melasma, solar lentigines, and conditions like freckles are common. The light-emitting diodes (LEDs) are the latest category of nonthermal and noninvasive phototherapy to be considered in skin pigmentation disorder treatment. PURPOSE: The purpose of this study was to investigate the effects of 660-nm LED on inhibition of melanogenesis. We investigated whether a 660-nm LED affected melanin synthesis in in vitro and in vivo models, and we explored the mechanisms involved...
October 1, 2016: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/27693716/downregulation-of-melanogenesis-drug-discovery-and-therapeutic-options
#16
Thanigaimalai Pillaiyar, Manoj Manickam, Sang-Hun Jung
Melanin, primarily responsible in humans for hair, eye and skin pigmentation, is produced by melanocytes through a process called melanogenesis. However, the abnormal accumulation of melanin causes dermatological problems such as café-au-lait macules ephelides (freckles), solar lentigo (age spots) and melasma, as well as cancer and vitiligo. Hence the regulation of melanogenesis is very important for treating hyperpigmentary disorders. Numerous antimelanogenic agents that target tyrosinase activity and/or stability, melanosome maturation, transfer and trafficking, or melanogenesis-related signaling pathways have been developed...
September 28, 2016: Drug Discovery Today
https://www.readbyqxmd.com/read/27688436/skin-hyperpigmentation-in-indian-population-insights-and-best-practice
#17
Stephanie Nouveau, Divya Agrawal, Malavika Kohli, Francoise Bernerd, Namita Misra, Chitra Shivanand Nayak
Skin pigmentation is one of the most strikingly variable phenotypes in humans, therefore making cutaneous pigmentation disorders frequent symptoms manifesting in a multitude of forms. The most common among them include lentigines, postinflammatory hyperpigmentation, dark eye circles, and melasma. Variability of skin tones throughout the world is well-documented, some skin tones being reported as more susceptible to pigmentation disorders than others, especially in Asia and India. Furthermore, exposure to ultraviolet radiation is known to trigger or exacerbate pigmentation disorders...
September 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27638442/phototherapy-in-cosmetic-dermatology
#18
Joshua Brownell, Stephanie Wang, Maria M Tsoukas
Light therapy has been incorporated into the art of healing and cosmesis for thousands of years and currently has found utility in many areas of medicine. Various modalities of cosmetic phototherapy are detailed, as well as the indications and mechanism of action for each modality. These modalities can be used to treat many common cosmetic conditions, including acne vulgaris, solar lentigo, and melasma. Phototherapy is considered a safe and effective option in the treatment of many of these disorders.
September 2016: Clinics in Dermatology
https://www.readbyqxmd.com/read/27605303/fractional-resurfacing-in-the-asian-patient-current-state-of-the-art
#19
Heidi Wat, Douglas C Wu, Henry Hin Lee Chan
BACKGROUND AND OBJECTIVE: Fractionated photothermolysis (FP) has revolutionized modern laser technology. By creating selective columns of microthermal damage, fractionated devices allows for greater treatment depths to be achieved without the prolonged downtime and risk of complications seen in traditional fully ablative laser resurfacing. Fractional resurfacing is a proven method to treat a variety of cutaneous conditions. In the Caucasian patient, a wide range of devices and treatment settings can be utilized safely and effectively...
September 8, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27594596/combination-of-fractional-qsrl-and-ipl-for-melasma-treatment-in-chinese-population
#20
La-Ga Tong, Yan Wu, Bin Wang, Xue-Gang Xu, Han-Deng Tu, Hong-Duo Chen, Yuan-Hong Li
BACKGROUND: Melasma is the most common and distressing pigmentary disorder presenting to dermatology clinics. Various treatment protocols for melasma have been suggested in the previous literature and applied in various clinical settings. However, no satisfactory therapy has been widely accepted. OBJECTIVE: To evaluate the efficiency and safety of a combination treatment with fractional Q-switched ruby laser (QSRL) and intense pulsed light (IPL) for melasma in Chinese population...
November 18, 2016: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
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