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https://www.readbyqxmd.com/read/29763564/inhibitors-of-melanogenesis-an-updated-review
#1
Thanigaimalai Pillaiyar, Vigneshwaran Namasivayam, Manoj Manickam, Sang Hun Jung
Melanins are pigment molecules that determine the skin, eye, and hair color of the human subject to its amount, quality and distribution. Melanocytes synthesize melanin and provide epidermal protection from various stimuli, such as harmful ultraviolet radiation, through the complex process called melanogenesis. However, a serious dermatological problems occur when the excessive production of melanin in different parts of the human body. These include freckles, melasma, senile lentigo, pigmented acne scars and cancer...
May 15, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29734511/factors-associated-with-quality-of-life-in-facial-melasma-a-cross-sectional-study
#2
Camila F Pollo, Luciane Db Miot, Silmara Meneguin, Hélio A Miot
BACKGROUND: Melasma is a common chronic focal hypermelanosis that affects photexposed areas as face, mainly in women at fertile age. It inflicts a significant impact in quality of life, nevertheless, quality of life scores (e.g. MELASQoL) are not strongly correlated with clinical severity (e.g. MASI) in facial melasma, suggesting that different factors can influence the perception of disease beyond the clinical extension or the intensity of pigmentation. OBJECTIVES: To explore clinical and sociodemographic aspects that influences MELASQoL scores...
May 7, 2018: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/29732522/a-split-face-study-comparison-of-picosecond-alexandrite-laser-and-q-switched-nd-yag-laser-in-the-treatment-of-melasma-in-asians
#3
Mei-Ching Lee, Ying-Fang Lin, Sindy Hu, Yau-Li Huang, Shyue-Luen Chang, Chun-Yu Cheng, Chun-Shin Chang
To evaluate efficacy and safety of picosecond 755 nm alexandrite laser as compared to 1064 nm QS-Nd:YAG laser for melasma treatment in Asians. Twelve patients received 4 sessions of treatments at 1-month interval in a split-face manner. The right side of each patient's face received 755 nm picosecond laser, and the other side received 1064 nm QS-Nd:YAG laser. Zoom handpiece of 755 nm picosecond laser at fluence of 0.88-1.18 J/cm2 was applied. The treatment protocol used for 1064 nm QS-Nd:YAG laser was 8 mm spot size at fluence of 2...
May 7, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29729698/poria-cocos-wolf-extracts-represses-pigmentation-in-vitro-and-in-vivo
#4
HyunKyung Lee, Hwa Jun Cha
In skin, melanocytes determine skin color using melanogenesis, which induces protective mechanism to oxidative stress and UV damage. However, when melanin is excessive produced by the various stimulus, the accumulated melanin induces hyperpigmentation disease such as melasma, freckles, Melanism ware induced. Therefore, it is implicated to finding potential agents for whitening to be used in cosmetic products. In our present study, we show that Poria cocos Wolf extracts decreased melanin synthesis in B16F10...
April 30, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29677015/oral-tranexamic-acid-for-the-treatment-of-melasma-a-review
#5
Harini R Bala, Senhong Lee, Celestine Wong, Amit G Pandya, Michelle Rodrigues
BACKGROUND: Melasma is a common acquired disorder of hyperpigmentation that commonly affects those with skin of color. Tranexamic acid (TXA) is a novel treatment for melasma that has a multimodal mechanism of action. OBJECTIVE: To provide a comprehensive review of the literature regarding the evidence on the mode of action, safety profile, and efficacy of TXA in the treatment of melasma. MATERIALS AND METHODS: The literature was searched for publications on TXA in the treatment of melasma using MEDLINE, Scopus, and Google Scholar...
April 19, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29659405/the-safety-and-efficacy-of-treatment-with-a-1-927-nm-diode-laser-with-and-without-topical-hydroquinone-for-facial-hyperpigmentation-and-melasma-in-darker-skin-types
#6
Monique J Vanaman Wilson, Isabela T Jones, Joanna Bolton, Lisa Larsen, Sabrina Guillen Fabi
BACKGROUND: The nonablative, fractional, 1,927-nm diode laser is theoretically a safe and effective treatment for hyperpigmentation and melasma in darker skin and may potentiate topical cosmeceutical delivery. OBJECTIVE: To evaluate the use of a nonablative, fractional, 1,927-nm diode laser with and without topical 2% hydroquinone (HQ) cream for moderate-to-severe facial hyperpigmentation in Fitzpatrick skin Types III-V. METHODS: Forty adults underwent 4 laser treatments at 2-week intervals and were randomized to daily application of 2% HQ cream or moisturizer...
April 13, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29657669/dual-effect-of-photobiomodulation-on-melasma-downregulation-of-hyperpigmentation-and-enhanced-solar-resistance-a-pilot-study
#7
Daniel Barolet
Overview. Melasma is a resistant, sun-induced facial hyperpigmentation capable of remaining present for decades with ensuing psychological distress. Treatment is difficult and focuses on an array of measures to reduce skin hyperpigmentation resulting from triggered hyperactive melanocytes. The pathogenesis of melanoma is not clearly understood but it has been reported that some growth factors and specific cell-signaling pathways are involved. Objective. The objective of the current study was to evaluate the use of pulsed photobiomodulation to modulate melasma via the regulation of gene expression pertaining to skin pigmentation...
April 2018: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29642438/sesamol-inhibited-melanogenesis-by-regulating-melanin-related-signal-transduction-in-b16f10-cells
#8
Po-Yuan Wu, Ya-Jhen You, Yi-Jung Liu, Chien-Wei Hou, Chin-Sheng Wu, Kuo-Ching Wen, Chien-Yih Lin, Hsiu-Mei Chiang
Melanin is synthesized through a series of interactions catalyzed by melanogenic enzymes such as tyrosinase, dopachrome tautomerase (tyrosinase-related protein-2; TRP-2), and tyrosinase-related protein-1 (TRP-1). Tyrosinase plays a key role in catalysing the initial and limiting steps of melanogenesis. The melanin that results from melanogenesis has the protective effect of absorbing ultraviolet radiation. However, overproduction of melanin, in addition to altering the appearance of skin, may lead to skin disorders such as melasma, solar lentigo, and postinflammatory hyperpigmentation...
April 7, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29606995/double-blind-placebo-controlled-trial-to-evaluate-the-effectiveness-of-polypodium-leucotomos-extract-in-the-treatment-of-melasma-in-asian-skin-a-pilot-study
#9
Chee-Leok Goh, Sai Yee Chuah, Steven Tien, Guan Thng, María Alejandra Vitale, Arancha Delgado-Rubin
Introduction: Melasma is a common pigmentary disorder with a multifactorial etiology that can hinder its management. The aqueous extract of the fern Polypodium leucotomos (PLE), Fernblock® (IFC, Madrid, Spain), has demonstrated antioxidant and photoprotective activities and has been used for the treatment of several pigmentary disorders. The aim of this study was to evaluate the efficacy and safety of oral PLE in the treatment of melasma in Asian patients. Methods: Forty healthy adult patients with clinical diagnoses of melasma who were receiving treatment with topical 4% hydroquinone cream and sunscreen with a sun protection factor (SPF) of 50+ were recruited for inclusion in this study from the National Skin Centre in Singapore...
March 2018: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29556371/%C3%AE-viniferin-improves-facial-hyperpigmentation-via-accelerating-feedback-termination-of-camp-pka-signaled-phosphorylation-circuit-in-facultative-melanogenesis
#10
Cheong-Yong Yun, Seon Mi Ko, Yong Pyo Choi, Beom Joon Kim, Jungno Lee, Jae Mun Kim, Ju Yeon Kim, Jin Yong Song, Song-Hee Kim, Bang Yeon Hwang, Jin Tae Hong, Sang-Bae Han, Youngsoo Kim
Rationale: cAMP up-regulates microphthalmia-associated transcription factor subtype M (MITF-M) and tyrosinase (Tyro) in the generation of heavily pigmented melanosomes. Here, we communicate a therapeutic mechanism of hyperpigmented disorder by α-viniferin, an active constituent of Caragana sinica . Methods: We used cAMP-elevated melanocyte cultures or facial hyperpigmented patches for pigmentation assays, and applied immunoprecipitation, immunobloting, RT-PCR or reporter gene for elucidation of the antimelanogenic mechanism...
2018: Theranostics
https://www.readbyqxmd.com/read/29554171/treatment-of-melasma-using-tranexamic-acid-what-s-known-and-what-s-next
#11
Sarah L Sheu
Tranexamic acid is a procoagulant agent that is approved by the US Food and Drug Administration for treatment of menorrhagia and to prevent hemorrhage in patients with hemophilia undergoing tooth extractions. Through its inhibitory effects on the plasminogen activation pathway, tranexamic acid also mitigates the UV radiation-induced pigmentation response. Systemic tranexamic acid has consistently been reported as an effective treatment of melasma, though its broad use may be limited by the risk for thromboembolism...
February 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29552277/melasma-in-men-a-review-of-clinical-etiological-and-management-issues
#12
REVIEW
Rashmi Sarkar, Pallavi Ailawadi, Shilpa Garg
Melasma is a common skin condition that affects both men and women. However, it is more commonly seen in women and dark-skinned individuals, such as in Hispanics, Asians, and African Americans who live in areas with intense ultraviolet radiation. Melasma is less common in men, but it negatively affects the quality of life in men as much as it does in women. While melasma has been studied in detail in women, however, there is a paucity of studies on the clinico- etiopathology and therapeutics of melasma in men...
February 2018: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29552273/are-natural-ingredients-effective-in-the-management-of-hyperpigmentation-a-systematic-review
#13
REVIEW
Jasmine C Hollinger, Kunal Angra, Rebat M Halder
BACKGROUND: Hyperpigmentation disorders are commonly encountered in dermatology clinics. Botanical and natural ingredients have gained popularity as alternative depigmenting products. OBJECTIVE: We sought to review clinical studies evaluating the use of different natural products in treating hyperpigmentation so clinicians are better equipped to educate their patients. Specific ingredients reviewed include azelaic acid, aloesin, mulberry, licorice extracts, lignin peroxidase, kojic acid, niacinamide, ellagic acid, arbutin, green tea, turmeric, soy, and ascorbic acid...
February 2018: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29532749/nanotechnological-advances-for-cutaneous-release-of-tretinoin-an-approach-to-minimize-side-effects-and-improve-therapeutic-efficacy
#14
Ana Claudia Pompeu Raminelli, Valeria Romero, Mohammad H Semreen, Gislaine Ricci Leonardi
The clinical efficacy of the topical tretinoin is widely studied and has been well established for many therapeutic interventions, among some, photoaging, acne, and melasma. However, the side effects, mainly cutaneous irritation, erythema, xerosis and peeling, remain major obstacle to the patient compliance. Besides, the insight regarding the drug delivery profile is essential to understand the therapeutic action of the drug. Herein we highlight further advances and an update on tretinoin delivery systems such as liposomes, niosomes, solid lipid nanoparticles, nanostructured lipid carriers, cyclodextrins, nanostructured polymers and other technological systems that reduce its side effects and improve the permeation profile to potentiate efficacy and drug safety on the skin...
March 12, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29461133/natural-options-for-management-of-melasma-a-review
#15
Mpofana Nomakhosi, Abrahamse Heidi
A blemish free, even-toned skin is universally associated with healthy skin. This reasoning makes people desire to have a flawless skin. Melanin is a naturally occurring pigment in humans. This pigment is responsible for skin, hair, and eye color, therefore determines our race and phenotypic appearance. On darker skin types, it is common that melanin production processes malfunctions. These malfunctions often lead to overproduction and secretion of melanin. As a result, unwanted pigmentary problems such melasma occur...
February 20, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29461121/topical-3-tranexamic-acid-enhances-the-efficacy-of-1064-nm-q-switched-neodymium-doped-yttrium-aluminum-garnet-laser-in-the-treatment-of-melasma
#16
Variya Laothaworn, Premjit Juntongjin
BACKGROUND: A QS-NdYAG laser (QSNYL) and topical tranexamic acid (TA) have been widely used. However, no study has yet reported the efficacy of using both QSNYL and TA as a combined treatment for melasma. OBJECTIVES: To evaluate the efficacy and adverse effects of topical 3% TA combined with 1064-nm QSNYL as a treatment for melasma. METHODS: A randomized, prospective, split-face, controlled trial was conducted. A 1064-nm QSNYL was performed on the entire face at baseline and 4 weeks later...
February 20, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29455565/pulsed-dye-laser-versus-intense-pulsed-light-in-melasma-a-split-face-comparative-study
#17
Arwa M Hassan, Nashwa N Elfar, Omnia M Rizk, Nahed Y Eissa
BACKGROUND: Recent reports suggest that melasma may have a vascular component. Vascular targeting lasers and light treatment can be a therapeutic option that will provide benefits to the patients. OBJECTIVES: To compare the efficacy and tolerability of pulsed dye laser (PDL) and intense pulsed light in treatment of melasma. PATIENTS AND METHODS: Twenty-eight Egyptian female patients with melasma were treated with PDL on the right hemiface (Group A) and with the intense pulsed light on the left hemiface (Group B)...
February 23, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29434427/picosecond-laser-treatment-for-tattoos-and-benign-cutaneous-pigmented-lesions-secondary-publication
#18
REVIEW
Kenichiro Kasai
Background and aims: The selective removal of tattoos and benign cutaneous pigmented lesions with laser energy evolved rapidly with the development of the nanosecond-domain Q-switched laser (ns-laser). Recently, however, a series of picosecond-domain lasers (ps-lasers) with pulsewidths less than 1 ns has become commercially available, enabling more efficient and faster removal of pigmented lesions in the field of dermatologic laser surgery. Rationale behind the ps-laser: The efficacy of the ns-laser depended on the theory of selective photothermolysis, whereby an extremely short pulse width was delivered less than the thermal relaxation time (TRT) of a target...
December 31, 2017: Laser Therapy
https://www.readbyqxmd.com/read/29431372/pigmentation-disorders-diagnosis-and-management
#19
Scott Plensdorf, Maria Livieratos, Nabil Dada
Pigmentation disorders are commonly diagnosed, evaluated, and treated in primary care practices. Typical hyperpigmentation disorders include postinflammatory hyperpigmentation, melasma, solar lentigines, ephelides (freckles), and café au lait macules. These conditions are generally benign but can be distressing to patients. Appropriate dermatologic history, skin examination, and skin biopsy, when appropriate, can help exclude melanoma and its precursors. In addition to addressing the underlying condition, hyperpigmentation is treated with topical agents, chemical peels, cryotherapy, light or laser therapy, or a combination of these methods...
December 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/29430289/quality-of-life-in-patients-with-melasma-in-turkish-women
#20
Hacer Uyanikoglu, Mustafa Aksoy
No abstract text is available yet for this article.
October 11, 2017: Dermatology Reports
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