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Melasma

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https://www.readbyqxmd.com/read/28216035/sun-protective-behaviors-in-patients-with-cutaneous-hyperpigmentation-a-cross-sectional-study
#1
Mayra B C Maymone, Hind H Neamah, Stephen A Wirya, Nicole M Patzelt, Pedro Q Zancanaro, Neelam A Vashi
BACKGROUND: Disorders of hyperpigmentation are seen commonly in clinical practice. Despite numerous studies investigating sun-protective habits among healthy persons, little is known about these behaviors within patient populations with hyperpigmentation disorders. OBJECTIVE: We sought to examine photo-protective behaviors and their associations in individuals with disorders of hyperpigmentation. METHODS: This cross-sectional study was conducted with 404 adults who complained of cutaneous hyperpigmentation...
February 15, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28212612/african-ancestry-is-associated-with-facial-melasma-in-women-a-cross-sectional-study
#2
Maria Paula Barbieri D'Elia, Marcela Calixto Brandão, Bruna Ribeiro de Andrade Ramos, Márcia Guimarães da Silva, Luciane Donida Bartoli Miot, Sidney Emanuel Batista Dos Santos, Hélio Amante Miot
BACKGROUND: Melasma is a chronic acquired focal hypermelanosis affecting photoexposed areas, especially for women during fertile age. Several factors contribute to its development: sun exposure, sex steroids, medicines, and family history. Melanic pigmentation pathway discloses several SNPs in different populations. Here, we evaluated the association between genetic ancestry and facial melasma. METHODS: A cross-sectional study involving women with melasma and an age-matched control group from outpatients at FMB-Unesp, Botucatu-SP, Brazil was performed...
February 17, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28178004/combined-jessner-solution-and-trichloroacetic-acid-versus-trichloroacetic-acid-alone-in-the-treatment-of-melasma-in-dark-skinned-patients
#3
Azza M Abdel-Meguid, Emad A Taha, Sahar A Ismail
BACKGROUND: Melasma is a common challenging pigmentary skin disorder especially in dark-skinned females urging them to seek medical help. Many modalities of treatment are available, but none is satisfactory. OBJECTIVE: To compare safety and efficacy of combined trichloroacetic acid (TCA) (20%-25%) and Jessner's solution versus TCA (20%-25%) alone in dark patients with melasma. MATERIALS AND METHODS: The study design was a split face, right-left, assessor-blinded, randomized controlled study...
February 6, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28161548/anti-melasma-codrug-of-retinoic-acid-assists-cutaneous-absorption-with-attenuated-skin-irritation
#4
Pei-Wen Hsieh, Chi-Feng Hung, Chih-Hung Lin, Chang-Wei Huang, Jia-You Fang
Melasma treatment with combined retinoic acid (RA) and hydroquinone (HQ) usually causes unsatisfactory outcomes and safety concerns. This study attempted to evaluate the cutaneous absorption and skin tolerance of the codrug conjugated with RA and HQ via ester linkage. The codrug's permeation of the pig skin was estimated using Franz diffusion cell. The codrug and parent drugs were comparatively examined for anti-inflammatory activity and tyrosinase inhibition. In vivo cutaneous irritation was assessed on nude mouse skin...
February 1, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28151024/pulsed-alexandrite-laser-for-treatment-of-melasma-in-asian-patients
#5
Chun-Yu Cheng, Yau-Li Huang, Mei-Ching Lee, Shyue-Luen Chang, Ying-Fang Lin, Sindy Hu
Background Melasma is a common acquired facial hypermelanosis with irregular brownish macules and patches. The clinical course is often fluctuated and refractory to treatment. The present study was conducted to evaluate the efficacy and safety of pulsed Alexandrite laser for the treatment of melasma. Material and method In the present study, we enrolled Asian patients with melasma. All the patients received four monthly treatments with a pulsed Alexandrite laser. The severity of melasma was evaluated by a blinded dermatologist, using the Modified Melasma Area and Severity Index (MMASI), and by patient assessment, using a visual analogue scale, at baseline, before each treatment, and at the 1-month and 3-month follow-up visits after the last treatment...
February 2, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28139161/clinical-efficacy-of-liposome-encapsulated-aloe-vera-on-melasma-treatment-during-pregnancy
#6
Masoumeh Ghafarzadeh, Ali Eatemadi
BACKGROUND: Melasma is a challenging dermatological condition during pregnancy. The aim of this study was to determine the clinical efficacy of a topical liposome encapsulated Aloe vera preparation, on melasma in pregnant women. In order to enhance the bioavailability of Aloe vera leaf gel extract (AGE), liposomes encapsulating Aloe vera were prepared and examined for their biochemical properties. METHODS: In this double-blinded, randomized clinical trial, two groups of pregnant women with melasma who were at their second trimester of pregnancy or later were studied...
January 31, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28134994/retrospective-analysis-of-the-treatment-of-melasma-lesions-exhibiting-increased-vascularity-with-the-595-nm-pulsed-dye-laser-combined-with-the-1927-nm-fractional-low-powered-diode-laser
#7
REVIEW
Elizabeth R C Geddes, Ashlyn B Stout, Paul M Friedman
BACKGROUND: Melasma presents a significant challenge to laser surgeons. Aggressive treatments often result in rebound melasma or post-inflammatory pigmentary alteration. Recent reports suggest melasma pathogenesis may have a vascular component. Spectrocolorimetry can detect subtle or sub-clinical telangiectatic erythema within melasma lesions. For certain patients identified by spectrocolorimetry, effective melasma treatment may include vascular-targeted therapy together with pigment-specific treatment modalities...
January 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28133910/tranexamic-acid-in-treatment-of-melasma-a-comprehensive-review-of-clinical-studies
#8
REVIEW
Mohammad Taraz, Somayeh Niknam, Amir Houshang Ehsani
Melasma is a human melanogenesis dysfunction that results in localized, chronic acquired hyperpigmentation of the skin. It has a significant impact on appearance, causing psychosocial and emotional distress, and reducing the quality of life of the affected patients. Tranexamic acid (TA) is a plasmin inhibitor used to prevent abnormal fibrinolysis to reduce blood loss and exerts its effect by reversibly blocking lysine binding sites on plasminogen molecules, thus inhibiting plasminogen activator (PA) from converting plasminogen to plasmin...
January 30, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28133891/the-effects-of-hydroporation-on-melasma-with-anti-aging-cocktail
#9
Je Byeong Chae, Seung Hye Yang, Sang Young Byun, Hye-Ryung Choi, Jung-Won Shin, Kyoung-Chan Park
BACKGROUND: Jet-M is a device for epidermal peeling and is used to deliver substances by spraying air and microdroplets. Previously, a case was treated with a mixed solution of copper-GHK, oligo-hyaluronic acid, Rhodiola extract, tranexamic acid, and β-glucan. The results showed significant improvement of aged skin. AIMS: This study was conducted to evaluate the effects of hydroporation on melasma with the formulation in a small group of volunteers. METHODS: Clinical effects were evaluated by both subjective and objective methods including melanin index (MI) and erythema index (EI) measurement...
January 29, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28126186/exogenous-ochronosis-in-facial-melasma
#10
M E Córdova, D O Pérez-Rojas, A D López-Marquet, R Arenas
No abstract text is available yet for this article.
January 23, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28122465/clinical-profile-and-triggering-factors-for-acquired-bilateral-nevus-of-ota-like-macules
#11
Qi Zhang, Cheng Tan, Pei Jiang, Gang Yang
BACKGROUD Acquired, bilateral nevus of Ota-like macules (ABNOM) is one of the most common dermal melanocytoses. Although there are some literatures on ABNOM, its clinical features and etiopathogenetic factors have not been fully understood. OBJECTIVE To determine the prevalence and characteristics of ABNOM among the Chinese patients. METHODS A survey was carried out using the clinical examination and a questionnaire on 3,212 first-time outpatients in our dermatology department, and 102 cases of ABNOM were subsequently enrolled...
January 25, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28095558/clinical-evaluation-of-a-4-hydroquinone-1-retinol-treatment-regimen-for-improving-melasma-and-photodamage-in-fitzpatrick-skin-types-iii-vi
#12
Marta I Rendon, Sylvia Barkovic
The bene ts of monotherapy with hydroquinone for melasma and retinoids for photodamaged skin is well established. Here we report results of a hydroquinone skincare regimen designed for melasma treatment combined with a cosmetic retinol cream on subjects presenting with both melasma and facial photodamage in a 24-week study. Improvement in melasma and photodamage ef cacy pa- rameters of melasma pigmentation intensity and melasma area and severity index (MASI), as well as overall photodamage and mottled hyperpigmentation were found by week 4, the rst post-baseline time point...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/27930379/reliability-validity-and-sensitivity-to-change-overtime-of-the-modified-melasma-area-and-severity-index-score
#13
Doaa A E Abou-Taleb, Ahmed K Ibrahim, Eman M K Youssef, Alaa E A Moubasher
BACKGROUND: The new modified Melasma Area and Severity Index (mMASI) score, the recently used outcome measure for melasma, has not been tested to determine its sensitivity to change in melasma. OBJECTIVE: To determine the reliability, validity, and sensitivity to change overtime of the mMASI score in assessment of the severity of melasma. METHODS: Pearson correlation, Cronbach alpha, and intraclass correlation coefficient were calculated to assess the reliability of the mMASI score...
February 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27926637/pigmentation-and-pregnancy-knowing-what-is-normal
#14
Amy Kalowitz Bieber, Kathryn J Martires, Jennifer A Stein, Jane M Grant-Kels, Marcia S Driscoll, Miriam Keltz Pomeranz
Changes in melanocytic nevi during pregnancy are frequently attributed to the new hormonal milieu and are dismissed without concern for malignancy. Recent studies suggest that pregnancy itself does not induce significant change in nevi, and delays in the assessment of changing moles may contribute to the often more advanced nature of melanomas diagnosed during or soon after pregnancy. Nevi on the breasts and abdomen can grow as a result of skin expansion, but studies have found no significant changes in nevi located in more stable areas such as the back or lower extremities...
January 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27918005/a-review-of-melasma-treatment-focusing-on-laser-and-light-devices
#15
Janet Y Li, Elizabeth Rc Geddes, Deanne M Robinson, Paul M Friedman
Melasma is a pigmentary disorder of unclear etiology with numerous treatment options and high recurrence rates. Laser and light therapies may be utilized cautiously as second- or third-line options for recalcitrant melasma, but low-energy settings are preferred due to the risk of postinflammatory hyperpigmentation and melasma stimulation. Commonly used lasers include the low-fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet laser, nonablative fractionated lasers, and intense pulsed light. Strict sun protection, concomitant use of bleaching agents, and maintenance treatments are necessary...
December 2016: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/27911217/laser-toning-for-melasma-a-single-centre-experience-with-38-970-cases
#16
Brian Tian
Melasma is a common pigmentation in Asian women. Lasers have been used to lighten melasma, although with variable outcomes and complications. In Asia, laser toning is a common technique used to safely lighten melasma. However, no large studies have been performed to validate efficacy. In our study, we demonstrate that in 38 970 Asian women, at least 35 890 patients (92.1%) had noticeable to excellent improvement in their melasma.
February 1, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/27911108/comparative-study-of-dual-pulsed-1-064-nm-q-switched-nd-yag-laser-and-single-pulsed-1-064-nm-q-switched-nd-yag-laser-by-using-zebrafish-model-and-prospective-split-face-analysis-of-facial-melasma
#17
Hee Won Jang, Seung Hyun Chun, Hae Chul Park, Hwa Jung Ryu, Il-Hwan Kim
BACKGROUND: Recently dual-pulsed low-fluence 1,064 nm Q-switched Nd:YAG (QSNY) laser has been developed for reducing complication during melasma treatment. OBJECTIVE: Comparison of the efficacy and safety between dual-pulsed mode and single-pulsed mode for the treatment of melasma. MATERIALS AND METHODS: In preclinical study, adult zebrafish were irradiated with dual-pulsed and single-pulsed mode. Changes of melanophore and cell death were assessed...
December 2, 2016: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/27904270/morphologic-changes-of-zebrafish-melanophore-after-intense-pulsed-light-and-q-switched-nd-yag-laser-irradiation
#18
Hwa Jung Ryu, Ji Min Lee, Hee Won Jang, Hae Chul Park, Im Joo Rhyu, Il-Hwan Kim
BACKGROUND: Recently, the pulse-in-pulse mode of intense pulsed light (IPL) has been used increasingly for the treatment of melasma. OBJECTIVE: To observe the morphologic changes in the melanophore in adult zebrafish after irradiation with conventional and pulse-in-pulse IPL and Q-switched Nd:YAG (QSNY) laser. METHODS: Adult zebrafish were irradiated with conventional and pulse-in-pulse mode of IPL. The conditions for conventional IPL were 3 mJ/cm(2), 560 nm filter, and pulse widths of 7, 20, and 35 msec...
December 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27902522/the-effect-of-topical-use-of-petroselinum-crispum-parsley-versus-that-of-hydroquinone-cream-on-reduction-of-epidermal-melasma-a-randomized-clinical-trial
#19
Shahla Khosravan, Ali Alami, Hossein Mohammadzadeh-Moghadam, Vahide Ramezani
Melasma disfigures the skin and thus influences people's self-image and self-concept. Therefore, melasma influences emotional and psychosocial health in addition to physical health. This clinical trial was performed to assess the effect of the topical use of Petroselinum crispum (parsley) on reduction of the severity of epidermal melasma.
January 2017: Holistic Nursing Practice
https://www.readbyqxmd.com/read/27854332/fractional-co%C3%A2-laser-pretreatment-facilitates-transdermal-delivery-of-two-vitamin-c-derivatives
#20
Chien-Yu Hsiao, Hsin-Ching Sung, Sindy Hu, Yau-Li Huang, Chun-Hsun Huang
BACKGROUND: Topical vitamin C derivatives have been used to treat melasma and used as a skin whitener. The aim of this study was to compare skin histology and permeation of l-ascorbic acid 2-phosphate sesquimagnesium salt (MAP-1) and magnesium l-ascorbic acid-2-phosphate (MAP-2) after fractional CO₂ laser pretreatment. METHODS: The effect of fractional laser treatment on porcine skin was examined by scanning electron microscopy and confocal laser scanning electron microscopy...
November 16, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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