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https://www.readbyqxmd.com/read/28434049/a-prospective-study-of-the-safety-and-efficacy-of-a-combined-bipolar-radiofrequency-intense-pulsed-light-and-infrared-diode-laser-treatment-for-global-facial-photoaging
#1
Min Jiang, Fang Yan, Mathew Avram, Zhong Lu
The clinical features of photoaging include: skin texture changes, laxity, rhytides, pigmentary changes, and vascular changes such as erythema and telangiectasias. In order to meet patients' increasing demands for improving all aspects of photoaging at one office visit, employing a multi-modality treatment for all aspects of photoaging has become increasingly desirable for the physician and patient alike. We examine a novel device that employs bipolar radiofrequency (RF), intense pulsed light (IPL), and infrared diode laser...
April 23, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28432372/evaluation-of-the-auditory-pathway-in-traffic-policemen
#2
Vipul Indora, Farah Khaliq, Neelam Vaney
BACKGROUND: Traffic policemen working at heavy traffic junctions are continuously exposed to high level of noise and its health consequences. OBJECTIVE: To assess the hearing pathway in traffic policemen by means of brainstem evoked response audiometry (BERA), mid-latency response (MLR), and slow vertex response (SVR). METHODS: In this observational comparative study, BERA, MLR, and SVR were tested in 35 male traffic policemen with field posting of more than 3 years...
April 2017: International Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28430879/role-of-phosphatase-and-tensin-homolog-pten-in-hypoxic-pulmonary-vasoconstriction
#3
Adrienn Krauszman, Tak Mak, Katalin Szaszi, Wolfgang M Kuebler
AIMS: Hypoxic pulmonary vasoconstriction (HPV) redistributes blood flow from poorly ventilated to better aerated areas in the lung, thereby optimizing ventilation-perfusion ratio (V/Q). Pulmonary artery smooth muscle cell (PASMC) contraction in response to hypoxia is triggered by Ca2+ influx via transient receptor potential canonical 6 (TRPC6) cation channels that have translocated to caveolae in the plasma membrane. Since phosphatase and tensin homolog (PTEN) was suggested to regulate TRPC6 in endothelial cells, we aimed to define its role in the hypoxic response of PASMCs and as a putative mediator of HPV...
April 18, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28420980/loss-of-melanopsin-expressing-ganglion-cell-subtypes-and-dendritic-degeneration-in-the-aging-human-retina
#4
Gema Esquiva, Pedro Lax, Juan J Pérez-Santonja, José M García-Fernández, Nicolás Cuenca
In mammals, melanopsin-expressing retinal ganglion cells (mRGCs) are, among other things, involved in several non-image-forming visual functions, including light entrainment of circadian rhythms. Considering the profound impact of aging on visual function and ophthalmic diseases, here we evaluate changes in mRGCs throughout the life span in humans. In 24 post-mortem retinas from anonymous human donors aged 10-81 years, we assessed the distribution, number and morphology of mRGCs by immunostaining vertical retinal sections and whole-mount retinas with antibodies against melanopsin...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28419726/chemotaxonomic-characterization-of-the-thaumarchaeal-lipidome
#5
Felix J Elling, Martin Könneke, Graeme W Nicol, Michaela Stieglmeier, Barbara Bayer, Eva Spieck, José R de la Torre, Kevin W Becker, Michael Thomm, James I Prosser, Gerhard J Herndl, Christa Schleper, Kai-Uwe Hinrichs
Thaumarchaeota are globally distributed and abundant microorganisms occurring in diverse habitats and thus represent a major source of archaeal lipids. The scope of lipids as taxonomic markers in microbial ecological studies is limited by the scarcity of comparative data on the membrane lipid composition of cultivated representatives, including the phylum Thaumarchaeota. Here, we comprehensively describe the core and intact polar lipid (IPL) inventory of ten ammonia-oxidizing thaumarchaeal cultures representing all four characterized phylogenetic clades...
April 17, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28413776/dissociable-neural-processes-during-risky-decision-making-in-individuals-with-internet-gaming-disorder
#6
Lu Liu, Gui Xue, Marc N Potenza, Jin-Tao Zhang, Yuan-Wei Yao, Cui-Cui Xia, Jing Lan, Shan-Shan Ma, Xiao-Yi Fang
Risk-taking is purported to be central to addictive behaviors. However, for Internet gaming disorder (IGD), a condition conceptualized as a behavioral addiction, the neural processes underlying impaired decision-making (risk evaluation and outcome processing) related to gains and losses have not been systematically investigated. Forty-one males with IGD and 27 healthy comparison (HC) male participants were recruited, and the cups task was used to identify neural processes associated with gain- and loss-related risk- and outcome-processing in IGD...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28413699/white-matter-connections-of-the-inferior-parietal-lobule-a-study-of-surgical-anatomy
#7
Joshua D Burks, Lillian B Boettcher, Andrew K Conner, Chad A Glenn, Phillip A Bonney, Cordell M Baker, Robert G Briggs, Nathan A Pittman, Daniel L O'Donoghue, Dee H Wu, Michael E Sughrue
INTRODUCTION: Interest in the function of the inferior parietal lobule (IPL) has resulted in increased understanding of its involvement in visuospatial and cognitive functioning, and its role in semantic networks. A basic understanding of the nuanced white-matter anatomy in this region may be useful in improving outcomes when operating in this region of the brain. We sought to derive the surgical relationship between the IPL and underlying major white-matter bundles by characterizing macroscopic connectivity...
April 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28387937/specific-connections-of-the-interpeduncular-subnuclei-reveal-distinct-components-of-the-habenulopeduncular-pathway
#8
Lely A Quina, Julie Harris, Hongkui Zeng, Eric E Turner
The habenulopeduncular pathway consists of the medial habenula (MHb), its output tract, the fasciculus retroflexus, and its principal target, the interpeduncular nucleus (IP). Several IP subnuclei have been described, but their specific projections and relationship to habenula inputs are not well understood. Here we have used viral, transgenic, and conventional anterograde and retrograde tract-tracing methods to better define the relationship between the dorsal and ventral MHb, the IP, and the secondary efferent targets of this system...
April 7, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28371266/autism-spectrum-disorders-and-the-amplitude-of-auditory-brainstem-response-wave-i
#9
Mariline Santos, Cristina Marques, Ana Nóbrega Pinto, Raquel Fernandes, Miguel Bebiano Coutinho, Cecília Almeida E Sousa
To determine whether children with autism spectrum disorders (ASDs) have an increased number of wave I abnormal amplitudes in auditory brainstem responses (ABRs) than age- and sex-matched typically developing children. This analytical case-control study compared patients with ASDs between the ages of 2 and 6 years and children who had a language delay not associated with any other pathology. Amplitudes of ABR waves I and V; absolute latencies (ALs) of waves I, III, and V; and interpeak latencies (IPLs) I-III, III-IV, and I-V at 90 dB were compared between ASD patients and normally developing children...
April 1, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28368998/diagnostic-ability-of-wide-field-retinal-nerve-fiber-layer-maps-using-swept-source-optical-coherence-tomography-for-detection-of-preperimetric-and-early-perimetric-glaucoma
#10
Won June Lee, Kyeong Ik Na, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
PURPOSE: To evaluate the diagnostic ability of wide-field retinal nerve fiber layer (RNFL) maps with swept-source optical coherence tomography (SS-OCT) for detection of preperimetric (PPG) and early perimetric glaucoma (EG). METHODS: One hundred eighty-four eyes, including 67 healthy eyes, 43 eyes with PPG, and 74 eyes with EG, were analyzed. Patients underwent a comprehensive ocular examination including red-free RNFL photography, visual field testing and wide-field SS-OCT scanning (DRI-OCT-1 Atlantis; Topcon, Tokyo, Japan)...
March 31, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28365233/an-interprofessional-learning-workshop-for-mammography-and-sonography-students-focusing-on-breast-cancer-care-and-management-via-simulation-a-pilot-study
#11
Eileen M Giles, Nayana Parange, Bronwyn Knight
RATIONALE AND OBJECTIVES: The literature surrounding interprofessional education claims that students who learn with, from, and about one another in well-designed interprofessional programs will practice together collaboratively upon graduation, given the skills to do so. The objective of this study was to examine attitudes to interprofessional practice before and after an interprofessional learning (IPL) activity. MATERIALS AND METHODS: A total of 35 postgraduate medical imaging students attended a week-long mammography workshop...
March 29, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28358911/assessment-of-the-retinal-posterior-pole-in-dominant-optic-atrophy-by-spectral-domain-optical-coherence-tomography-and-microperimetry
#12
Massimo Cesareo, Elena Ciuffoletti, Alessio Martucci, Jacopo Sebastiani, Roberto Pietro Sorge, Eleonora Lamantea, Barbara Garavaglia, Federico Ricci, Andrea Cusumano, Carlo Nucci, Francesco Brancati
BACKGROUND: To assess posterior pole (PP) retinal structure in patients with genetically confirmed autosomal dominant optic atrophy (ADOA) using new spectral domain optical coherence tomography (SD-OCT) segmentation technology. To analyze retinal PP thickness in relation to retinal sensitivity data from microperimetry (MP) in ADOA patients. METHODS AND FINDINGS: This prospective cross-sectional study included 11 patients with ADOA and 11 age-matched healthy subjects...
2017: PloS One
https://www.readbyqxmd.com/read/28356402/the-biochemical-properties-of-the-two-arabidopsis-thaliana-isochorismate-synthases
#13
Keith M Macaulay, Geraldine Ann Heath, Alessio Ciulli, Alexandra Marie Murphy, Chris Abell, John Peter Carr, Alison G Smith
The important plant hormone salicylic acid (SA; 2-hydroxybenzoic acid) regulates several key plant responses including, most notably, defence against pathogens. A key enzyme for SA biosynthesis is isochorismate synthase (ICS), which converts chorismate to isochorismate, for which there are two genes in Arabidopsis thaliana . One ( AtICS1 ) has been shown to be required for increased SA biosynthesis in response to pathogens and its expression can be stimulated throughout the leaf by virus infection and exogenous SA...
March 29, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28352605/photo-epilation-with-intense-pulsed-light-for-thinning-of-anterior-hairline-after-hairline-correction-surgery-in-east-asians
#14
Jae Hyun Park, Seung Yong Lee, Seung Hyun You, Na Rae Kim
BACKGROUND: Thin hairs are critical to achieve natural result in female hairline correction surgery. However, there are few studies on the usefulness of hair thinning by intense pulsed light (IPL) after hairline correction surgery in East Asian females. METHODS: Hair thinning using IPL was performed in 54 women who had complained about thick hairs along the frontal hairline after hairline correction surgery. Patient mean age was 31.2 years old and patients were an average of 2...
March 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/28351449/aberrant-interhemispheric-functional-connectivity-within-default-mode-network-and-its-relationships-with-neurocognitive-features-in-cognitively-normal-apoe-%C3%AE%C2%B5-4-elderly-carriers
#15
Hanna Lu, Suk Ling Ma, Savio Wai Ho Wong, Cindy W C Tam, Sheung-Tak Cheng, Sandra S M Chan, Linda C W Lam
BACKGROUND: Default mode network (DMN) is vulnerable to the effects of APOE genotype. Given the reduced brain volumes and APOE ε 4-related brain changes in elderly carriers, it is less known that whether these changes would influence the functional connectivity and to what extent. This study aimed to examine the functional connectivity within DMN, and its diagnostic value with age-related morphometric alterations considered. METHODS: Whole brain and seed-based resting-state functional connectivity (RSFC) analysis were conducted in cognitively normal APOE ε 4 carriers and matched non-carriers (N=38)...
May 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28348642/metagenomic-analysis-of-a-complex-community-present-in-pond-sediment
#16
Vivek Negi, Rup Lal
The metagenomic profiling of complex communities is gaining immense interest across the scientific community. A complex community present in the pond sediment of a water body located close to a hexachlorocyclohexane (HCH) production site of the Indian Pesticide Limited (IPL) (Chinhat, Lucknow) was selected in an attempt to identify and analyze the unique microbial diversity and functional profile of the site. In this study, we supplement the metagenomic study of pond sediment with a variety of binning approaches along with an in depth functional analysis...
2017: Journal of Genomics
https://www.readbyqxmd.com/read/28348634/trans-synaptic-retrograde-degeneration-following-hemispherectomy-in-childhood
#17
Sian E Handley, Vasiliki S Panteli, Alki Liasis
Trans-synaptic retrograde degeneration (TRD) in the human visual system has been established. However there are few studies demonstrating macular thinning of the Retinal Ganglion cell Layer and/or Inner Plexiform layer (RGCL-IPL), corresponding to an acquired homonymous hemianopia. We report a 17 year old with a homonymous hemianopia, secondary to a hemispherectomy for intractable epilepsy. Three years following hemispherectomy, Optical Coherence Tomography (OCT) revealed evidence of TRD, corresponding to his complete homonymous hemianopia...
April 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/28347837/a-novel-therapeutic-with-two-snap-25-inactivating-proteases-shows-long-lasting-anti-hyperalgesic-activity-in-a-rat-model-of-neuropathic-pain
#18
Jiafu Wang, Laura Casals-Diaz, Tomas Zurawski, Jianghui Meng, Orla Moriarty, John Nealon, Om Prakash Edupuganti, Oliver Dolly
A pressing need exists for long-acting, non-addictive medicines to treat chronic pain, a major societal burden. Botulinum neurotoxin type A (BoNT/A) complex - a potent, specific and prolonged inhibitor of neuro-exocytosis - gives some relief in several pain disorders, but not for all patients. Our study objective was to modify BoNT/A to overcome its inability to block transmitter release elicited by high [Ca(2+)]i and increase its limited analgesic effects. This was achieved by fusing a BoNT/A gene to that for the light chain (LC) of type/E...
March 24, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28344564/investigating-the-grammatical-and-pragmatic-origins-of-wh-questions-in-children-with-autism-spectrum-disorders
#19
Manya Jyotishi, Deborah Fein, Letitia Naigles
Compared to typically developing children, children with autism (ASD) show delayed production of wh-questions. It is currently controversial the degree to which such deficits derive from social-pragmatic requirements and/or because these are complex grammatical structures. The current study employed the intermodal preferential looking (IPL) paradigm, which reduces social-pragmatic demands. The IPL paradigm can help distinguish these proposals, as successful comprehension promotes the "pragmatics-origins" argument whereas comprehension difficulties would implicate a "grammatical-origins" argument...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28337128/connexin36-expression-in-the-mammalian-retina-a-multiple-species-comparison
#20
Tamás Kovács-Öller, Gábor Debertin, Márton Balogh, Alma Ganczer, József Orbán, Miklós Nyitrai, Lajos Balogh, Orsolya Kántor, Béla Völgyi
Much knowledge about interconnection of human retinal neurons is inferred from results on animal models. Likewise, there is a lack of information on human retinal electrical synapses/gap junctions (GJ). Connexin36 (Cx36) forms GJs in both the inner and outer plexiform layers (IPL and OPL) in most species including humans. However, a comparison of Cx36 GJ distribution in retinas of humans and popular animal models has not been presented. To this end a multiple-species comparison was performed in retinas of 12 mammals including humans to survey the Cx36 distribution...
2017: Frontiers in Cellular Neuroscience
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