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https://www.readbyqxmd.com/read/28210739/retinal-oxidative-stress-at-the-onset-of-diabetes-determined-by-synchrotron-ftir-widefield-imaging-towards-diabetes-pathogenesis
#1
Ebrahim Aboualizadeh, Mahsa Ranji, Christine M Sorenson, Reyhaneh Sepehr, Nader Sheibani, Carol J Hirschmugl
Diabetic retinopathy is a microvascular complication of diabetes that can lead to blindness. In the present study, we aimed to determine the nature of diabetes-induced, highly localized biochemical changes in the neuroretina at the onset of diabetes. High-resolution synchrotron Fourier transform infrared (s-FTIR) wide field microscopy coupled with multivariate analysis (PCA-LDA) was employed to identify biomarkers of diabetic retinopathy with spatial resolution at the cellular level. We compared the retinal tissue prepared from 6-week-old Ins2(Akita/+) heterozygous (Akita/+, N = 6; a model of diabetes) male mice with the wild-type (control, N = 6) mice...
February 17, 2017: Analyst
https://www.readbyqxmd.com/read/28206829/validity-of-low-contrast-letter-acuity-as-a-visual-performance-outcome-measure-for-multiple-sclerosis
#2
Laura J Balcer, Jenelle Raynowska, Rachel Nolan, Steven L Galetta, Raju Kapoor, Ralph Benedict, Glenn Phillips, Nicholas LaRocca, Lynn Hudson, Richard Rudick
Low-contrast letter acuity (LCLA) has emerged as the leading outcome measure to assess visual disability in multiple sclerosis (MS) research. As visual dysfunction is one of the most common manifestations of MS, sensitive visual outcome measures are important in examining the effect of treatment. Low-contrast acuity captures visual loss not seen in high-contrast visual acuity (HCVA) measurements. These issues are addressed by the MS Outcome Assessments Consortium (MSOAC), including representatives from advocacy organizations, Food and Drug Administration (FDA), European Medicines Agency (EMA), National Institute of Neurological Disorders and Stroke (NINDS), academic institutions, and industry partners along with persons living with MS...
February 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28183861/tool-selection-and-the-ventral-dorsal-organization-of-tool-related-knowledge
#3
Michael J Tobia, Christopher R Madan
Tool selection is a cognitive process necessary for tool use, and may rely on distinct knowledge under different conditions. This fMRI experiment was designed to identify neural substrates mediating tool selection under different conditions. Participants performed a picture-matching task that presented a recipient object and an action-goal, and required the selection of the best tool object from among four candidates. Some trials allowed selection of the prototypical tool, whereas others forced selection of either a functionally substitutable or impossible tool...
February 2017: Physiological Reports
https://www.readbyqxmd.com/read/28183829/retinal-structure-assessed-by-oct-as-a-biomarker-of-brain-development-in-children-born-small-for-gestational-age
#4
Victoria Pueyo, Teresa Pérez, Inmaculada González, Irene Altemir, Galadriel Gimenez, Esther Prieto, Cristina Paules, Daniel Oros, Javier Lopez-Pison, Nicolás Fayed, Gracián Garcia-Martí, Roberto Sanz-Requena, Miguel Angel Marin
PURPOSE: To identify differences in neuronal tissue from retinal and brain structures in children born small for gestational age (SGA) with no abnormality in neonatal brain ultrasonography and no previous neurological impairment, and to evaluate the relationship between retinal structure and brain changes in school-age children born SGA. METHODS: Two cohorts of children were recruited: 25 children born SGA and 25 children born with an appropriate birth weight according to gestational age...
February 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28178968/imatinib-relaxes-the-pulmonary-venous-bed-of-guinea-pigs
#5
Nina A Maihöfer, Said Suleiman, Daniela Dreymüller, Paul W Manley, Rolf Rossaint, Stefan Uhlig, Christian Martin, Annette D Rieg
BACKGROUND: Recently, the IMPRES study revealed that systemic imatinib improves exercise capacity in patients with advanced pulmonary arterial hypertension. Imatinib blocks the tyrosine kinase activity of the platelet-derived growth factor (PDGF)-receptor (PDGFR), acts antiproliferative and relaxes pulmonary arteries. However so far, the relaxant effects of imatinib on pulmonary veins (PVs) and on the postcapillary resistance are unknown, although pulmonary hypertension (PH) due to left heart disease (LHD) is most common and primarily affects PVs...
February 8, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28164458/comparison-of-hair-removal-efficacy-and-side-effect-of-neodymium-yttrium-aluminum-garnet-laser-and-intense-pulsed-light-systems-18-month-follow-up
#6
Georgina Zita Szima, Eszter Anna Janka, Anikó Kovács, Blanka Bortély, Edina Bodnár, Irina Sawhney, Éva Szabó, Éva Remenyik
BACKGROUND: Photothermal destruction of hair shaft melanin with intense pulsed light (IPL) and neodymium:yttrium-aluminum-garnet (Nd:YAG) laser has become an effective treatment of hair removal. AIMS: Our aim was to compare efficacy, satisfactory levels, safety, and side effects of Nd:YAG and IPL in hair reduction. METHODS: This was a prospective randomized intrapatient, right-left, assessor-blinded comparison of Nd:YAG vs IPL. There were 38 volunteers recruited...
February 6, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28160714/estimation-of-the-critical-quality-attributes-for-hydroxypropyl-methylcellulose-with-near-infrared-spectroscopy-and-chemometrics
#7
Qingli Guo, Lei Nie, Lian Li, Hengchang Zang
With the implementation of quality by design (QbD), critical attributes of raw material (drug substance and excipients) are of significantly importance in pharmaceutical manufacturing process. It is desirable for the quality control of critical material attributes (CMAs) of excipients to ensure the quality of end product. This paper explored the feasibility of an at-line method for the quantitative analysis of hydroxypropoxy group in hydroxypropyl methylcellulose (HPMC) with near infrared spectroscopy (NIRS)...
January 5, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28160289/melanopsin-expressing-human-retinal-ganglion-cells-subtypes-distribution-and-intraretinal-connectivity
#8
Jens Hannibal, Anders Tolstrup Christensen, Steffen Heegaard, Jan Fahrenkrug, Jens Folke Kiilgaard
Intrinsically photosensitive retinal ganglion cells (ipRGCs) expressing the photopigment melanopsin belong to a heterogenic population of RGCs which regulate the circadian clock, masking behavior, melatonin suppression, the pupillary light reflex and sleep/wake cycles. The different functions seem to be associated to different subtypes of melanopsin cells. In rodents, subtype classification has associated subtypes to function. In primate and human retina such classification has so far, not been applied. In the present study using antibodies against N- and C-terminal parts of human melanopsin, confocal microscopy and 3D reconstruction of melanopsin immunoreactive (-ir) RGCs, we applied the criteria used in mouse on human melanopsin-ir RGCs...
February 3, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28151966/optical-coherence-tomography-angiography-findings-in-stargardt-disease
#9
Rodolfo Mastropasqua, Lisa Toto, Enrico Borrelli, Luca Di Antonio, Peter A Mattei, Alfonso Senatore, Marta Di Nicola, Cesare Mariotti
BACKGROUND: to assess vessel density of superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris (CC) in advanced Stargardt disease (STGD) using optical coherence tomography angiography (OCTA) and correlate these findings with macular function using pattern electroretinogram (PERG) and multifocal electroretinogram (mfERG). METHODS: Twelve patients (24 eyes) with advanced STGD underwent vessel densities and macular thickness measurements using OCTA...
2017: PloS One
https://www.readbyqxmd.com/read/28146354/selective-light-induced-patterning-of-carbon-nanotube-silver-nanoparticle-composite-to-produce-extremely-flexible-conductive-electrodes
#10
Inhyuk Kim, Kyoohee Woo, Zhaoyang Zhong, Eonseok Lee, Dongwoo Kang, Sunho Jeong, Young-Man Choi, Yunseok Jang, Sin Kwon, Jooho Moon
Recently, highly flexible conductive features have been widely demanded for the development of various electronic applications, such as foldable displays, deformable lighting, disposable sensors, and flexible batteries. Herein, we report for the first time a selective photonic sintering-derived, highly reliable patterning approach for creating extremely flexible carbon nanotube (CNT)/silver nanoparticle (Ag NP) composite electrodes that can tolerate severe bending (20 000 cycles at a bending radius of 1 mm)...
February 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28145480/attentional-deployment-impacts-neural-response-to-regret
#11
Zhiyuan Liu, Lin Li, Li Zheng, Min Xu, Fanzhi Anita Zhou, Xiuyan Guo
Regret results from comparing non-optimal outcomes containing both gain and loss parts to better alternatives during decision-making. The present fMRI study aimed to explore whether levels of regret could change when gain or loss part of a non-optimal outcome was focused during a sequential risk taking task, i.e. the effect of an important emotional regulation strategy named as attentional deployment on regret. Participants were asked to open a series of boxes consecutively and decided when to stop. Each box contained a reward, except for one containing a devil to zero one's gain in the trial...
February 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28141749/thickness-of-the-macula-retinal-nerve-fiber-layer-and-ganglion-cell-inner-plexiform-layer-in-the-age-related-macular-degeneration-the-repeatability-study-of-spectral-domain-optical-coherence-tomography
#12
Il-Hwan Shin, Woo-Hyuk Lee, Jong-Joo Lee, Young-Joon Jo, Jung-Yeul Kim
PURPOSE: To determine the repeatability of measuring the thickness of the central macula, retinal nerve fiber layer, and ganglion cell-inner plexiform layer (GC-IPL) using spectral domain optical coherence tomography (Cirrus HD-OCT) in eyes with age-related macular degeneration. METHODS: One hundred and thirty-four eyes were included. The measurement repeatability was assessed by an experienced examiner who performed two consecutive measurements using a 512 × 128 macular cube scan and a 200 × 200 optic disk cube scan...
January 30, 2017: Retina
https://www.readbyqxmd.com/read/28135360/retinal-architecture-and-melanopsin-mediated-pupillary-response-characteristics-a-putative-pathophysiologic-signature-for-the-retino-hypothalamic-tract-in-multiple-sclerosis
#13
Ethan Meltzer, Peter V Sguigna, Adnan Subei, Shin Beh, Eric Kildebeck, Darrel Conger, Amy Conger, Marlen Lucero, Benjamin S Frohman, Ashley N Frohman, Shiv Saidha, Steven Galetta, Peter A Calabresi, Robert Rennaker, Teresa C Frohman, Randy H Kardon, Laura J Balcer, Elliot M Frohman
Importance: A neurophysiologic signature of the melanopsin-mediated persistent constriction phase of the pupillary light reflex may represent a surrogate biomarker for the integrity of the retinohypothalamic tract, with potential utility for investigating alterations in homeostatic mechanisms associated with brain disorders and implications for identifying new treatments. Objective: To characterize abnormalities of retinal architecture in patients with multiple sclerosis (MS) and corresponding alterations in the melanopsin-mediated sustained pupillary constriction response...
January 30, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28133888/alterations-of-the-outer-retina-in-non-arteritic-anterior-ischemic-optic-neuropathy-detected-using-spectral-domain-optical-coherence-tomography
#14
Philipp Ackermann, Maike Brachert, Philipp Albrecht, Marius Ringelstein, David Finis, Gerd Geerling, Orhan Aktas, Rainer Guthoff
BACKGROUND: Changes in peripapillary and macular retinal layer thickness in non-arteritic anterior ischemic optic neuropathy (NAION) measured using spectral-domain optical coherence tomography may reflect a characteristic disease pattern. Advanced software enables retinal layer segmentation. In this study, we compared retinal layer thicknesses in acute and chronic NAION. DESIGN: A single-center cross-sectional analysis in a university clinic. PARTICIPANTS: 14 eyes with acute (<7 days) and 13 eyes with chronic NAION and 20 age-matched healthy eyes...
January 30, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28106555/optical-coherence-tomography-reveals-retinal-neuroaxonal-thinning-in-frontotemporal-dementia-as-in-alzheimer-s-disease
#15
Laura Ferrari, Su-Chun Huang, Giuseppe Magnani, Alessandro Ambrosi, Giancarlo Comi, Letizia Leocani
BACKGROUND: Alzheimer's disease (AD) and frontotemporal dementia (FTD) are leading causes of cognitive decline. Optical coherence tomography (OCT) allows the measurement of thickness of retinal neuroaxonal layers. While in AD and mild cognitive impairment (MCI), retinal nerve fiber layer (RNFL) thinning is frequently reported, less information is available on ganglion cell layer-inner plexiform layer (GCL-IPL). Data on FTD are lacking. OBJECTIVE: To obtain cross-sectional information on RNFL and GCL-IPL thickness among MCI, AD, FTD, and healthy controls (HC), and their correlations with dementia severity...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28103154/facilitator-training-program-the-universit%C3%A3-laval-interprofessional-initiative
#16
Élise Milot, Anne-Claire Museux, Emmanuelle Careau
A facilitator training program (FTP) for interprofessional learning (IPL) facilitators has been developed at Université Laval. This article describes the impacts of this program as perceived by the 22 IPL facilitators involved and outlines recommendations. Two qualitative data collection strategies were used to document the facilitators' pedagogical needs and views of the program's impacts. Results suggest that the FTP's pedagogical approach was effective. The IPL facilitators became more aware of their challenges and identified concrete strategies to use...
January 19, 2017: Social Work in Health Care
https://www.readbyqxmd.com/read/28096653/applicability-of-automatic-spectral-domain-optical-coherence-tomography-for-glaucoma-mass-screening
#17
Tadashi Nakano, Takeshi Hayashi, Toru Nakagawa, Toru Honda, Satoshi Owada, Hitoshi Endo, Masayuki Tatemichi
PURPOSE: To perform a preliminary evaluation of the applicability of automatic spectral domain optical coherence tomography (ASD-OCT) for glaucoma mass screening in a population-based setting. METHODS: Information using ASD-OCT (thicknesses of the macular retinal nerve fiber layer [mRNFL], disc retinal nerve fiber layer [dRNFL], ganglion cell layer [GCL] + inner plexiform layer [IPL]; GCL+, and ganglion cell complex [GCL + IPL + RNFL; GCL++]) was obtained from 245 eyes of 123 glaucomatous subjects and 1,454 eyes of 727 normal subjects...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28092808/antinociceptive-effect-of-co-administered-nmda-and-histamine-h4-receptor-antagonists-in-a-rat-model-of-acute-pain
#18
Renata Wolińska, Anna Leśniak, Małgorzata Żochowska, Mariusz Sacharczuk, Katarzyna Kieć-Kononowicz, Magdalena Bujalska-Zadrożny
BACKGROUND: The histamine H4 receptor (H4R) has attracted a lot of attention in terms of its role in antinociception. The N-Methyl-d-aspartic acid (NMDA) receptor is a well-characterized participant in pain pathways. However, it's influence on H4R signaling is poorly understood. Thus, in the present study we investigated the effect of a selective H4R antagonist JNJ7777120 (25mg/kg) and a NMDA receptor antagonist MK-801 (0.1-10μg) on nociceptive thresholds in a rat acute pain model. METHODS: The influence of intrathecally (it), intracerebroventricularly (icv) and intraplantarly (ipl) administered MK-801 co-injected with JNJ7777120 administered intraperitoneally (ip) was determined in the modified Randall-Selitto paw pressure, the tail flick and plantar tests...
October 29, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28079163/steady-state-and-dynamic-network-modes-for-perceptual-expectation
#19
Uk-Su Choi, Yul-Wan Sung, Seiji Ogawa
Perceptual expectation can attenuate repetition suppression, the stimulus-induced neuronal response generated by repeated stimulation, suggesting that repetition suppression is a top-down modulatory phenomenon. However, it is still unclear which high-level brain areas are involved and how they interact with low-level brain areas. Further, the temporal range over which perceptual expectation can effectively attenuate repetition suppression effects remains unclear. To elucidate the details of this top-down modulatory process, we used two short and long inter-stimulus intervals for a perceptual expectation paradigm of paired stimulation...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28077369/the-relationship-between-central-visual-field-sensitivity-and-macular-ganglion-cell-inner-plexiform-layer-thickness-in-glaucoma
#20
Ji-Woong Lee, Esteban Morales, Farideh Sharifipour, Navid Amini, Fei Yu, Abdelmonem A Afifi, Anne L Coleman, Joseph Caprioli, Kouros Nouri-Mahdavi
AIMS: To explore the correlation of local macular ganglion cell/inner plexiform layer (GC/IPL) thickness measurements with sensitivity at individual test locations on the central 10-2 visual fields (VFs) in patients with glaucoma. METHODS: One hundred thirty-seven eyes of 125 patients with spectral domain optical coherence tomography (OCT) and 10-2 VFs were included. The exported thickness matrices (200×200) of GC/IPL measurements were centred on the fovea. Total deviation values at each test location were correlated with the 20 000 GC/IPL thickness measurements in the corresponding inferior or superior hemiretina, and areas of highest correlation were plotted...
January 11, 2017: British Journal of Ophthalmology
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