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https://www.readbyqxmd.com/read/28106555/optical-coherence-tomography-reveals-retinal-neuroaxonal-thinning-in-frontotemporal-dementia-as-in-alzheimer-s-disease
#1
Laura Ferrari, Su-Chun Huang, Giuseppe Magnani, Alessandro Ambrosi, Giancarlo Comi, Letizia Leocani
BACKGROUND: Alzheimer's disease (AD) and frontotemporal dementia (FTD) are leading causes of cognitive decline. Optical coherence tomography (OCT) allows the measurement of thickness of retinal neuroaxonal layers. While in AD and mild cognitive impairment (MCI), retinal nerve fiber layer (RNFL) thinning is frequently reported, less information is available on ganglion cell layer-inner plexiform layer (GCL-IPL). Data on FTD are lacking. OBJECTIVE: To obtain cross-sectional information on RNFL and GCL-IPL thickness among MCI, AD, FTD, and healthy controls (HC), and their correlations with dementia severity...
January 18, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28103154/facilitator-training-program-the-universit%C3%A3-laval-interprofessional-initiative
#2
Élise Milot, Anne-Claire Museux, Emmanuelle Careau
A facilitator training program (FTP) for interprofessional learning (IPL) facilitators has been developed at Université Laval. This article describes the impacts of this program as perceived by the 22 IPL facilitators involved and outlines recommendations. Two qualitative data collection strategies were used to document the facilitators' pedagogical needs and views of the program's impacts. Results suggest that the FTP's pedagogical approach was effective. The IPL facilitators became more aware of their challenges and identified concrete strategies to use...
January 19, 2017: Social Work in Health Care
https://www.readbyqxmd.com/read/28096653/applicability-of-automatic-spectral-domain-optical-coherence-tomography-for-glaucoma-mass-screening
#3
Tadashi Nakano, Takeshi Hayashi, Toru Nakagawa, Toru Honda, Satoshi Owada, Hitoshi Endo, Masayuki Tatemichi
PURPOSE: To perform a preliminary evaluation of the applicability of automatic spectral domain optical coherence tomography (ASD-OCT) for glaucoma mass screening in a population-based setting. METHODS: Information using ASD-OCT (thicknesses of the macular retinal nerve fiber layer [mRNFL], disc retinal nerve fiber layer [dRNFL], ganglion cell layer [GCL] + inner plexiform layer [IPL]; GCL+, and ganglion cell complex [GCL + IPL + RNFL; GCL++]) was obtained from 245 eyes of 123 glaucomatous subjects and 1,454 eyes of 727 normal subjects...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28092808/antinociceptive-effect-of-co-administered-nmda-and-histamine-h4-receptor-antagonists-in-a-rat-model-of-acute-pain
#4
Renata Wolińska, Anna Leśniak, Małgorzata Żochowska, Mariusz Sacharczuk, Katarzyna Kieć-Kononowicz, Magdalena Bujalska-Zadrożny
BACKGROUND: The histamine H4 receptor (H4R) has attracted a lot of attention in terms of its role in antinociception. The N-Methyl-d-aspartic acid (NMDA) receptor is a well-characterized participant in pain pathways. However, it's influence on H4R signaling is poorly understood. Thus, in the present study we investigated the effect of a selective H4R antagonist JNJ7777120 (25mg/kg) and a NMDA receptor antagonist MK-801 (0.1-10μg) on nociceptive thresholds in a rat acute pain model. METHODS: The influence of intrathecally (it), intracerebroventricularly (icv) and intraplantarly (ipl) administered MK-801 co-injected with JNJ7777120 administered intraperitoneally (ip) was determined in the modified Randall-Selitto paw pressure, the tail flick and plantar tests...
October 29, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28079163/steady-state-and-dynamic-network-modes-for-perceptual-expectation
#5
Uk-Su Choi, Yul-Wan Sung, Seiji Ogawa
Perceptual expectation can attenuate repetition suppression, the stimulus-induced neuronal response generated by repeated stimulation, suggesting that repetition suppression is a top-down modulatory phenomenon. However, it is still unclear which high-level brain areas are involved and how they interact with low-level brain areas. Further, the temporal range over which perceptual expectation can effectively attenuate repetition suppression effects remains unclear. To elucidate the details of this top-down modulatory process, we used two short and long inter-stimulus intervals for a perceptual expectation paradigm of paired stimulation...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28077369/the-relationship-between-central-visual-field-sensitivity-and-macular-ganglion-cell-inner-plexiform-layer-thickness-in-glaucoma
#6
Ji-Woong Lee, Esteban Morales, Farideh Sharifipour, Navid Amini, Fei Yu, Abdelmonem A Afifi, Anne L Coleman, Joseph Caprioli, Kouros Nouri-Mahdavi
AIMS: To explore the correlation of local macular ganglion cell/inner plexiform layer (GC/IPL) thickness measurements with sensitivity at individual test locations on the central 10-2 visual fields (VFs) in patients with glaucoma. METHODS: One hundred thirty-seven eyes of 125 patients with spectral domain optical coherence tomography (OCT) and 10-2 VFs were included. The exported thickness matrices (200×200) of GC/IPL measurements were centred on the fovea. Total deviation values at each test location were correlated with the 20 000 GC/IPL thickness measurements in the corresponding inferior or superior hemiretina, and areas of highest correlation were plotted...
January 11, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28068388/the-association-between-foveal-morphology-and-macular-pigment-spatial-distribution-an-ethnicity-study
#7
Irene Ctori, Byki Huntjens
PURPOSE: Macular pigment (MP) spatial distribution varies considerably among individuals. We investigated ethnic variations in MP spatial distribution in relation to foveal architecture. METHODS: We measured MP optical density (MPOD) using heterochromatic flicker photometry (MAP test, City, University of London) in 76 white, 80 South Asian and 70 black volunteers (18 to 39 years). MPOD spatial profiles were classified objectively as exponential, ring-like or central dip, based on deviations away from an exponential fit...
2017: PloS One
https://www.readbyqxmd.com/read/28068348/optical-determination-of-lead-chrome-green-in-green-tea-by-fourier-transform-infrared-ft-ir-transmission-spectroscopy
#8
Xiaoli Li, Kaiwen Xu, Yuying Zhang, Chanjun Sun, Yong He
The potential of Fourier transform infrared (FT-IR) transmission spectroscopy for determination of lead chrome green in green tea was investigated based on chemometric methods. Firstly, the qualitative analysis of lead chrome green in tea was performed based on partial least squares discriminant analysis (PLS-DA), and the correct rate of classification was 100%. And then, a hybrid method of interval partial least squares (iPLS) regression and successive projections algorithm (SPA) was proposed to select characteristic wavenumbers for the quantitative analysis of lead chrome green in green tea, and 19 wavenumbers were obtained finally...
2017: PloS One
https://www.readbyqxmd.com/read/28059657/language-outcomes-after-resection-of-dominant-inferior-parietal-lobule-gliomas
#9
Derek G Southwell, Marco Riva, Kesshi Jordan, Eduardo Caverzasi, Jing Li, David W Perry, Roland G Henry, Mitchel S Berger
OBJECTIVE The dominant inferior parietal lobule (IPL) contains cortical and subcortical regions essential for language. Although resection of IPL tumors could result in language deficits, little is known about the likelihood of postoperative language morbidity or the risk factors predisposing to this outcome. METHODS The authors retrospectively examined a series of patients who underwent resections of gliomas from the dominant IPL. Postoperative language outcomes were characterized across the patient population...
January 6, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28057643/retinal-segmented-layers-with-strong-aquaporin-4-expression-suffered-more-injuries-in-neuromyelitis-optica-spectrum-disorders-compared-with-optic-neuritis-with-aquaporin-4-antibody-seronegativity-detected-by-optical-coherence-tomography
#10
Chun Xia Peng, Hong Yang Li, Wei Wang, Jun Qing Wang, Lei Wang, Quan Gang Xu, Shan Shan Cao, Huan Fen Zhou, Shuo Zhao, Shi Hui Wei
PURPOSE: To evaluate retinal segmented layer alterations in optic neuritis (ON) in an AQP4-Ab seropositive (AQP4-Ab+/ON) cohort and in neuromyelitis optica (NMO) with ON eyes (NMO-ON) compared with an AQP4-Ab seronegative ON (AQP4-Ab-/ON) cohort using optical coherence tomography (OCT). METHODS: We recruited 109 patients with ON (161 eyes) and 47 healthy controls. All patients with ON were subdivided into three subcohorts: 37 patients (54 eyes) with AQP4-Ab+/ON, 45 patients (65 eyes) with AQP4-Ab-/ON and 27 patients (42 eyes) with NMO-ON...
January 5, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28057536/transcranial-alternating-current-stimulation-to-the-inferior-parietal-lobe-decreases-mu-suppression-to-egocentric-but-not-allocentric-hand-movements
#11
Monica B Berntsen, Nicholas R Cooper, Vincenzo Romei
Egocentric vs. allocentric perspective during observation of hand movements has been related to self-other differentiation such that movements observed from an egocentric viewpoint have been considered as self-related while movements observed from an allocentric viewpoint have been considered as belonging to someone else. Correlational studies have generally found that egocentric perspective induces greater neurophysiological responses and larger behavioral effects compared to an allocentric perspective. However, recent studies question previous findings by reporting greater (μ) suppression and greater transcranial magnetic stimulation (TMS)-induced motor-evoked potentials (MEPs) during observation of allocentric compared to egocentric movements...
January 3, 2017: Neuroscience
https://www.readbyqxmd.com/read/28057458/the-inferior-parietal-lobule-and-temporoparietal-junction-a-network-perspective
#12
Kajsa M Igelström, Michael S A Graziano
Information processing in specialized, spatially distributed brain networks underlies the diversity and complexity of our cognitive and behavioral repertoire. Networks converge at a small number of hubs - highly connected regions that are central for multimodal integration and higher-order cognition. We review one major network hub of the human brain: the inferior parietal lobule and the overlapping temporoparietal junction (IPL/TPJ). The IPL is greatly expanded in humans compared to other primates and matures late in human development, consistent with its importance in higher-order functions...
January 2, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28057456/retina-and-choroid-of-diabetic-patients-without-observed-retinal-vascular-changes-a-longitudinal-study
#13
Joana Tavares Ferreira, Rita Proença, Marta Alves, Arnaldo Dias-Santos, Bruno Oliveira Santos, João Paulo Cunha, Ana Luísa Papoila, Luís Abegão Pinto
PURPOSE: To identify changes in choroidal thickness (CT) and all retinal layers of diabetic patients without diabetic retinopathy (DR) after one year of follow-up. DESIGN: Prospective observational cohort study. METHODS: Overall, 125 diabetic patients without DR were included. Two visits were scheduled: the first visit (V1) and a second visit after 12 months (V2). At both visits, patients received a complete ophthalmologic evaluation that included OCT...
January 2, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28054250/pupil-cycle-time-as-indicator-of-visual-pathway-dysfunction-in-multiple-sclerosis
#14
Eyyup Karahan, Omer Karti, Aslı Koskderelioglu, Dilek Top Karti, Murat Uyar, Murat Yildirim Kale, Muhtesem Gedizlioglu
To evaluate the value of pupil cycle time (PCT) as an indicator of optic nerve dysfunction in patients with multiple sclerosis (MS), 42 patients with MS and 35 control subjects were included to the study. Patients with MS with a history of ON were accepted as group 1, without a history of ON as group 2 and healthy control subjects as group 3. Groups were compared with Chi-square and one-way ANOVA tests. Correlations of PCT results with age, best corrected visual acuity, duration of MS, visual field (VF) test, visual evoked potential (VEP) latans, retinal nerve fiber layer (RNFL), and ganglion cell layer-inner plexiform layer (GCL-IPL) thicknesses were analyzed...
January 4, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/28041615/functional-anatomy-of-the-macaque-temporo-parieto-frontal-connectivity
#15
REVIEW
Elena Borra, Giuseppe Luppino
The primate parietal lobe is primarily dedicated to the processing of sensory information for the guidance of motor behavior, based on the integration of sensory with motor signals (sensorimotor transformations), mediated by specific, strong, and reciprocal connections with the motor cortex. Sensorimotor transformations have been regarded as an automatic process carried out independently from the temporal cortex, which is considered the location where sensory information is used for perceptual processes. However, both human and non-human primate studies have shown interactions between these two regions in different aspects of sensorimotor and cognitive processes...
December 18, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28024436/international-consensus-statement-on-the-assessment-of-interprofessional-learning-outcomes
#16
Gary D Rogers, Jill E Thistlethwaite, Elizabeth S Anderson, Madeleine Abrandt Dahlgren, Ruby E Grymonpre, Monica Moran, Dujeepa D Samarasekera
Regulatory frameworks around the world mandate that health and social care professional education programs graduate practitioners who have the competence and capability to practice effectively in interprofessional collaborative teams. Academic institutions are responding by offering interprofessional education (IPE); however, there is as yet no consensus regarding optimal strategies for the assessment of interprofessional learning (IPL). The Program Committee for the 17th Ottawa Conference in Perth, Australia in March, 2016, invited IPE champions to debate and discuss the current status of the assessment of IPL...
December 26, 2016: Medical Teacher
https://www.readbyqxmd.com/read/28006783/altered-long-and-short-range-functional-connectivity-in-patients-with-betel-quid-dependence-a-resting-state-functional-mri-study
#17
Tao Liu, Jianjun Li, Zhiqiang Zhang, Qiang Xu, Guangming Lu, Shixiong Huang, Mengjie Pan, Feng Chen
OBJECTIVE: Addiction is a chronic relapsing brain disease. Brain structural abnormalities may constitute an abnormal neural network that underlies the risk of drug dependence. We hypothesized that individuals with Betel Quid Dependence (BQD) have functional connectivity alterations that can be described by long- and short-range functional connectivity density(FCD) maps. METHODS: We tested this hypothesis using functional magnetic resonance imaging (fMRI) data from subjects of the Han ethnic group in Hainan, China...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28005183/altered-gray-matter-volume-in-stable-chronic-obstructive-pulmonary-disease-with-subclinical-cognitive-impairment-an-exploratory-study
#18
Chunrong Wang, Yanhui Ding, Bixian Shen, Dehong Gao, Jie An, Kewen Peng, Gangqiang Hou, Liqiu Zou, Mei Jiang, Shijun Qiu
Gray matter volume deficits have been identified in cognitively impaired patients with chronic obstructive pulmonary disease (COPD). However, it remains unknown whether the gray matter volume is altered in COPD patients with subclinical cognitive impairment. To determine whether any gray matter abnormalities are present in these patients, neuropsychological tests and structural MRI data were analyzed from 60 patients with COPD and 60 age-, gender-, education-, and handedness-matched normal controls (NCs). The COPD patients had similar Mini-Mental State Examination (MMSE) scores compared with the NCs...
December 22, 2016: Neurotoxicity Research
https://www.readbyqxmd.com/read/27999530/disturbed-interhemispheric-functional-connectivity-rather-than-structural-connectivity-in-irritable-bowel-syndrome
#19
Rongfeng Qi, Chang Liu, Yifei Weng, Qiang Xu, Liya Chen, Fangyu Wang, Long J Zhang, Guang M Lu
Neuroimaging studies have demonstrated that irritable bowel syndrome (IBS)-a relapsing functional bowel disorder-presents with disrupted brain connections. However, little is known about the alterations of interhemispheric functional connectivity and underlying structural connectivity in IBS. This study combined resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion tensor imaging (DTI) to investigate changes in interhemispheric coordination in IBS patients. Resting-state functional and structural magnetic resonance images were acquired from 65 IBS patients and 67 healthy controls (HCs; matched for age, sex and educational level)...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27997986/anatomy-and-spatial-organization-of-m%C3%A3-ller-glia-in-mouse-retina
#20
Jingjing Wang, Matthew L O'Sullivan, Dibyendu Mukherjee, Vanessa M Puñal, Sina Farsiu, Jeremy N Kay
Müller glia, the most abundant glia of vertebrate retina, have an elaborate morphology characterized by a vertical stalk that spans the retina and branches in each retinal layer. Müller glia play diverse, critical roles in retinal homeostasis, which are presumably enabled by their complex anatomy. However, much remains unknown, particularly in mouse, about the anatomical arrangement of Müller cells and their arbors, and how these features arise in development. Here we use membrane-targeted fluorescent proteins to reveal the fine structure of mouse Müller arbors...
December 20, 2016: Journal of Comparative Neurology
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