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https://www.readbyqxmd.com/read/29349656/correlations-among-multifocal-electroretinography-and-optical-coherence-tomography-findings-in-patients-with-parkinson-s-disease
#1
Metin Unlu, Duygu Gulmez Sevim, Murat Gultekin, Cagatay Karaca
To assess the correlation between functional and anatomical evaluations with multifocal electroretinography (mfERG) and spectral-domain optical coherence tomography (SD-OCT) in patients with Parkinson's disease (PD). This cross-sectional study involved 116 eyes of 58 patients with PD and 30 age- and sex-matched control subjects. All study participants underwent a comprehensive neuro-ophthalmic examination, retinal single-layer thicknesses and volumes, and peripapillary retinal nerve fiber layer (pRNFL) measurements with SD-OCT, and the patients' mfERG recordings were evaluated...
January 18, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29348593/temporal-diabetes-induced-biochemical-changes-in-distinctive-layers-of-mouse-retina
#2
Ebrahim Aboualizadeh, Christine M Sorenson, Alex J Schofield, Miriam Unger, Nader Sheibani, Carol J Hirschmugl
To discover the mechanisms underlying the progression of diabetic retinopathy (DR), a more comprehensive understanding of the biomolecular processes in individual retinal cells subjected to hyperglycemia is required. Despite extensive studies, the changes in the biochemistry of retinal layers during the development of DR are not well known. In this study, we aimed to determine a more detailed understanding of the natural history of DR in Akita/+ (type 1 diabetes model) male mice with different duration of diabetes...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29337617/intrapulmonary-delivery-of-cpg-odn-microdroplets-provides-protection-against-escherichia-coli-septicemia-in-neonatal-broiler-chickens
#3
Kalhari Bandara Goonewardene, Shelly Popowich, Thushari Gunawardana, Ashish Gupta, Shanika Kurukulasuriya, Ruwani Karunarathna, Betty Chow-Lockerbie, Khawaja Ashfaque Ahmed, Suresh K Tikoo, Marianna Foldvari, Philip Willson, Susantha Gomis
Synthetic oligodeoxynucleotides (ODN) containing unmethylated cytosine phosphodiester guanine (CpG) motifs (CpG-ODN) are effective immunostimulatory agents against a variety of viral, bacterial, and protozoan diseases in different animals including poultry. We have recently demonstrated that in ovo injection of CpG-ODN confers protection in neonatal chickens against bacterial septicemias. The objective of this study was to investigate the effectiveness of needle-free intrapulmonary (IPL) delivery of CpG-ODN microdroplets against Escherichia coli infection in neonatal chicks...
December 2017: Avian Diseases
https://www.readbyqxmd.com/read/29336132/auditory-system-synchronization-and-cochlear-function-in-patients-with-normal-hearing-with-tinnitus-comparison-of-multiple-feature-with-longer-duration-and-single-feature-with-shorter-duration-tinnitus
#4
Sujoy Kumar Makar, Geetha Mukundan, Geeta Gore
OBJECTIVE: To observe cochlear and brainstem function in normal hearing ears with tinnitus using DPOAE and ABR audiometry. DESIGN: Case-control study. SAMPLE SIZE: Included 60 normal hearing male patients with age less than 45 years; control group consisted of 30 patients without tinnitus and the study group consisted of those with unilateral tinnitus of at least 6 month duration. Pure tone audiometry, tinnitus matching (pitch & loudness), DPOAE (SNR & Amplitude) and ABR results of absolute latency of wave I, III and V, with IPL difference of I-III, III-V & I-V, and ILD-V were investigated...
December 1, 2017: International Tinnitus Journal
https://www.readbyqxmd.com/read/29336034/quantitative-evaluation-of-collagen-and-elastic-fibers-after-intense-pulsed-light-treatment-of-mouse-skin
#5
Luciana L Faucz, Sonia E Will, Consuelo J Rodrigues, Henrique Hesse, Angelina C Moraes, Durvanei A Maria
BACKGROUND AND OBJECTIVE: The aging of human skin includes intrinsic aging and photo-aging, which are characterized by a decrease in collagen and the deposition of abnormal elastic fibers. Intense pulsed light (IPL) sources are widely used in medicine to treat various cosmetic problems, including photo-damaged skin. Few studies have examined the microscopic changes produced by IPL. The objective of this study was to quantitatively evaluate the effects of IPL on collagen and elastic fibers in mice...
January 16, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29331902/the-use-of-interprofessional-learning-and-simulation-in-undergraduate-nursing-programs-to-address-interprofessional-communication-and-collaboration-an-integrative-review-of-the-literature
#6
REVIEW
Benedikte M Granheim, Julie M Shaw, Martha Mansah
OBJECTIVE: To identify how simulation and interprofessional learning are used together in undergraduate nursing programs and undertaken in schools of nursing to address interprofessional communication and collaboration. DESIGN: An integrative literature review. DATA SOURCES: The databases CINAHL, ProQuest, PubMed, Scopus, PsycInfo and Science Direct were searched to identify articles from 2006 to 2016 that reported on the use of IPL and simulation together in undergraduate nursing education...
December 29, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/29325429/a-novel-method-for-re-positioning-suboptimally-preoperatively-placed-nephrostomy-tubes-for-pcnl-without-renal-re-puncture
#7
Yazeed Barghouthy, Vasileios Kourmpetis, Snir Dekalo, Yuval Bar-Yosef, Simon Conti, Alexander Greenstein, Mario Sofer
OBJECTIVE: Nephrostomy tubes (NT) inserted in emergency settings by interventional radiologists are frequently unsuitable for subsequent percutaneous nephrolithotomy (PCNL). We report a novel method of adjusting these NTs to be used as PCNL tracts and avoid renal re-puncture. PATIENTS AND METHODS: A retrospective search of 981 consecutive PCNLs performed in our institution between 2002-2017 identified all patients with preoperatively inserted NTs. The NTs unsuitable for PCNL were adjusted by a novel approach in which a 5-mm incision was made at the ideal puncture location (IPL) as indicated under fluoroscopic guidance...
January 12, 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29322583/motor-imagery-training-kinesthetic-imagery-strategy-and-inferior-parietal-fmri-activation
#8
Florent Lebon, Ulrike Horn, Martin Domin, Martin Lotze
Motor imagery (MI) is the mental simulation of action frequently used by professionals in different fields. However, with respect to performance, well-controlled functional imaging studies on MI training are sparse. We investigated changes in fMRI representation going along with performance changes of a finger sequence (error and velocity) after MI training in 48 healthy young volunteers. Before training, we tested the vividness of kinesthetic and visual imagery. During tests, participants were instructed to move or to imagine moving the fingers of the right hand in a specific order...
January 10, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29317136/localization-of-the-zinc-binding-tubulin-polymerization-promoting-protein-in-the-mice-and-human-eye
#9
Robert G Tripon, Judit Oláh, Tajwar Nasir, Lajos Csincsik, Chee Lok Li, Sándor Szunyogh, Haiyan Gong, Jane M Flinn, Judit Ovádi, Imre Lengyel
Tubulin Polymerization Promoting Protein (TPPP/p25) modulates the dynamics and stability of the microtubule network by its bundling and acetylation enhancing activities that can be modulated by the binding of zinc to TPPP/p25. Its expression is essential for the differentiation of oligodendrocytes, the major constituents of the myelin sheath, and has been associated with neuronal inclusions. In this paper, evidence is provided for the expression and localization of TPPP/p25 in the zinc-rich retina and in the oligodendrocytes in the optic nerve...
December 27, 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29307184/ion-pairing-with-spermine-targets-theophylline-to-the-lungs-via-the-polyamine-transport-system
#10
Faiza Benaouda, Stuart A Jones, Jasminder Chana, Benedetta M Dal Corno, David J Barlow, Robert C Hider, Clive P Page, Ben Forbes
Certain xenobiotics, such as paraquat, are sequestered into the lungs from the systemic circulation by the polyamine transporter system (PTS). The aim of this study was to investigate whether ion-pairing a drug (theophylline) with a PTS substrate (spermine) provides a means of using this active transport mechanism to target drug delivery to the lungs. Fourier transform infrared spectroscopy showed that two of the amines of spermine interact with C-N7 and C6=O of theophylline, leaving two free amines to interact with the PTS...
January 8, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29304147/the-organization-of-melanopsin-immunoreactive-cells-in-microbat-retina
#11
Mi-Jin Jeong, Hang-Gu Kim, Chang-Jin Jeon
Intrinsically photosensitive retinal ganglion cells (ipRGCs) respond to light and play roles in non-image forming vision, such as circadian rhythms, pupil responses, and sleep regulation, or image forming vision, such as processing visual information and directing eye movements in response to visual clues. The purpose of the present study was to identify the distribution, types, and proportion of melanopsin-immunoreactive (IR) cells in the retina of a nocturnal animal, i.e., the microbat (Rhinolophus ferrumequinum)...
2018: PloS One
https://www.readbyqxmd.com/read/29302814/evaluation-of-white-matter-hyperintensities-and-retinal-fiber-layer-ganglion-cell-layer-inner-plexiform-layer-and%C3%A2-choroidal-layer-in-migraine-patients
#12
Ali Zeynel Abidin Tak, Yıldızhan Sengul, Şemsettin Bilak
The aim of our study is to assess retinal nerve fiber layer (RNFL), the ganglion cell layer (GCL), inner-plexiform layer (IPL), and choroidal layer in migraine patients with white matter lesion (WML) or without WML, using spectral domain optical coherence tomography (OCT). To our study, 77 migraine patients who are diagnosed with migraine in accordance to the International Classification of Headache Disorders (ICHD)-3 beta and 43 healthy control are included. In accordance to cranial MRI, migraine patients are divided into two groups as those who have white matter lesions (39 patients), and those who do not have a lesion (38 patients)...
January 4, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29302200/reexamination-of-dopaminergic-amacrine-cells-in-the-rabbit-retina-confocal-analysis-with-double-and-triple-labeling-immunohistochemistry
#13
Jong Woo Lee, Min Young Lim, Yong Soo Park, Su Jin Park, In-Beom Kim
Dopaminergic amacrine cells (DACs) are among the most well-characterized neurons in the mammalian retina, and their connections to AII amacrine cells have been described in detail. However, the stratification of DAC dendrites differs based on their location in the inner plexiform layer (IPL), raising the question of whether all AII lobules are modulated by dopamine release from DACs. The present study aimed to clarify the relationship between DACs and AII amacrine cells, and to further elucidate the role of dopamine at synapses with AII amacrine cell...
December 2017: Experimental Neurobiology
https://www.readbyqxmd.com/read/29300881/causal-contributions-of-the-sma-to-alertness-and-consciousness-interactions
#14
Mar Martín-Signes, Carlos Pérez-Serrano, Ana B Chica
Phasic alertness facilitates conscious perception through a fronto-striatal network, including the supplementary motor area (SMA). The functioning of the ventral attentional network has been related to the alerting system, overlapping with the ventral branch of the superior longitudinal fasciculus (SLF III). In this study, we use repetitive transcranial magnetic stimulation (rTMS) and a conscious detection task with near-threshold stimuli that could be preceded by an alerting tone to explore the causal implication of the SMA in the relationship between phasic alertness and conscious perception...
December 29, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29295735/photodynamic-therapy-interventions-in-facial-photodamage-a-systematic-review
#15
G Sanclemente, V Ruiz-Cañas, J M Miranda, A P Ferrín, P A Ramirez, G N Hernandez
INTRODUCTION: Photodynamic therapy (PDT) involves the combination of a light source and a photosensitizing agent to induce tissue damage via the generation of singlet oxygen. Although topical PDT has been approved for other indications, its use in facial photodamage is uncertain. AIMS: To assess the efficacy and safety of PDT in facial skin photoaging. METHODS: All randomized clinical trials (RCTs) evaluating the efficacy and safety of any form of topical PDT for the treatment of facial photodamage (dermatoheliosis) or photoaging in patients older than 18 years, were included...
December 30, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29290184/efficacy-of-intense-pulse-light-therapy-and-tripple-combination-cream-versus-intense-pulse-light-therapy-and-tripple-combination-cream-alone-in-epidermal-melasma-treatment
#16
Nafila Shakeeb, Sahibzada Mahmood Noor, Ghafoor Ullah, Mohammand Majid Paracha
OBJECTIVE: To compare the efficacy of intense pulse light therapy (IPL) and triple combination cream (TCC) versus intense pulse light therapy and triple combination cream alone in epidermal melasma treatment, downgrading MASI score to more than 10. STUDY DESIGN: Randomized controlled trial. PLACE AND DURATION OF STUDY: Dermatology Department, Lady Reading Hospital, Peshawar, from August 2014 to January 2015. METHODOLOGY: Patients of 18-45 years were included in the study with Fitzpatrick skin type II-V...
January 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29288107/memory-deficits-after-aneurysmal-subarachnoid-hemorrhage-an-fmri-study
#17
Jiabin Su, Tongzhou E, Qihao Guo, Yu Lei, Yuxiang Gu
BACKGROUND: Patients suffer from aneurysmal subarachnoid hemorrhage (aSAH) are thought to have cognitive impairment. However, little is known about characteristics of functional imaging in aSAH patients OBJECTIVE: To explore the whole brain activity pattern in aSAH patients using amplitude of low-frequency fluctuation (ALFF) and functional connectivity (FC). METHOD: 50 aSAH patients and 30 healthy controls were recruited and subjected to a resting-state functional magnetic resonance imaging scan and cognitive tasks...
December 26, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29283135/retinal-nerve-fiber-layer-and-ganglion-cell-layer-changes-on-optical-coherence-tomography-in-early-multiple-sclerosis-and-optic-neuritis-cases
#18
Ganesh Pillay, Anita Ganger, Digvijay Singh, Rohit Bhatia, Pradeep Sharma, Vimla Menon, Rohit Saxena
PURPOSE: To study the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) changes on optical coherence tomography in early multiple sclerosis (MS) patients. METHODS: A prospective cohort study was conducted at a tertiary care center. Patients of early MS (expanded disability status scale <3) with or without optic neuritis (ON) and idiopathic ON were included. Twenty age-matched individuals were taken as controls. Changes in RNFL and GCL thickness were evaluated along with the correlation with visual function parameters such as visual acuity, contrast sensitivity, and visual evoked response at first visit and again at six months...
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29259999/progressive-inner-nuclear-layer-dysfunction-in-non-optic-neuritis-eyes-in-ms
#19
Yuyi You, Elizabeth C Graham, Ting Shen, Con Yiannikas, John Parratt, Vivek Gupta, Joshua Barton, Michael Dwyer, Michael H Barnett, Clare L Fraser, Stuart L Graham, Alexander Klistorner
Objective: To investigate primary retinal functional changes in non-optic neuritis (ON) eyes of patients with MS by full-field electroretinography (ERG). Methods: Seventy-seven patients with relapsing-remitting MS with no history of clinical ON in at least 1 eye and 30 healthy controls were recruited in the cohort study. Full-field ERGs were recorded, and retinal optical coherence tomography scans were performed to assess the thicknesses of peripapillary retinal nerve fiber layer (RNFL) and retinal ganglion cell layer-inner plexiform layer (GCL-IPL)...
January 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29250711/objective-evaluation-of-the-effects-of-intense-pulsed-light-treatment-on-asian-skin-by-reflectance-confocal-microscopy-analysis
#20
Wenjia Sun, Jiaqiang Wu, Hui Qian, Juemin Zhao, Leihong Xiang, Chengfeng Zhang
This study aimed to evaluate the effect of IPL treatment on Asian skin by reflectance confocal microscopy (RCM) analysis. Ten Asian female volunteers (39~54 years old, Fitzpatrick skin type III~IV) received five monthly IPL treatments. RCM skin images were evaluated, and several skin physiological parameters including thickness of stratum corneum, minimal thickness of epidermis, thickness of basal layer, density of dermal papillae, and mean diameter of papillae capillaries were measured both at baseline and 1 month after the last treatment...
December 18, 2017: Lasers in Medical Science
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