keyword
https://read.qxmd.com/read/38531504/the-opportunities-and-challenges-of-the-disease-modifying-immunotherapy-for-type-1-diabetes-a-systematic-review-and-meta-analysis
#1
JOURNAL ARTICLE
Chu Lin, Suiyuan Hu, Xiaoling Cai, Fang Lv, Wenjia Yang, Geling Liu, Xiaolin Yang, Linong Ji
There are multiple disease-modifying immunotherapies showing the potential of preventing or delaying the progression of type 1 diabetes (T1D). We designed and performed this systematic review and meta-analysis to gain an overview of what a role immunotherapy plays in the treatment of T1D. We searched PubMed, Embase and Cochrane Central Register of Controlled Trials (CENTRAL) from inception to December 2023. We included clinical trials of immunotherapy conducted in patients with T1D that reported the incidence of hypoglycemia or changes from baseline in at least one of following outcomes: 2h and 4h mixed-meal-stimulated C-peptide area under the curve (AUC), fasting C-peptide, daily insulin dosage, glycated hemoglobin (HbA1c) and fasting plasma glucose (FPG)...
March 24, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38529396/safety-tolerability-pharmacokinetics-and-pharmacokinetic-pharmacodynamic-modeling-of-cetagliptin-in-patients-with-type-2-diabetes-mellitus
#2
JOURNAL ARTICLE
Chen Zhou, Sufeng Zhou, Jie Wang, Lijun Xie, Zhanhui Lv, Yuqing Zhao, Lu Wang, Huan Luo, Daosheng Xie, Feng Shao
AIMS: To evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of cetagliptin (CAS number:2243737-33-7) in Chinese patients with type 2 diabetes mellitus (T2DM). A population PK/PD model was developed to quantify the PK and PD characteristics of cetagliptin in patients. MATERIALS AND METHODS: 32 Chinese adults with T2DM were enrolled in this study. The subjects were randomly assigned to receive either cetagliptin (50 mg or 100 mg), placebo, or sitagliptin (100 mg) once daily for 14 days...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38527010/establishment-of-reference-interval-for-hemoglobin-a1c-and-other-hemoglobin-subfractions-for-healthy-saudi-adults
#3
JOURNAL ARTICLE
Anwar Borai, Kiyoshi Ichihara, Suhad Bahijri, Abeer Alsofyani, Mohieldin Elsayid, Haitham Husain, Sultanah Boraie, Naif Sannan, Ziad Kalantan, Majdi Jan, Maha Gassas, Mohammed Harbi, Norah Alrowaili, Mohammed Almohammadi, Hawazen Zarif, Mansour Qurashi
BACKGROUND: The establishment of Reference Intervals (RIs) for Hemoglobin A1C and other hemoglobin subfractions (A1A, A1B, F, LA1C, A0) is of utmost importance in screening, diagnosing, and monitoring diabetes and other hemoglobin abnormalities through the application of high-pressure liquid chromatography (HPLC) technique. Because there are no locally established RIs for these parameters, it is essential to establish RIs specific to the Saudi population to accurately diagnose and monitor diabetic individuals and identify abnormal levels in hemoglobin subfractions...
2024: PloS One
https://read.qxmd.com/read/38526862/effect-of-regular-physical-activity-and-lifestyle-changes-on-insulin-resistance-in-patients-after-kidney-transplantation
#4
JOURNAL ARTICLE
Karol Granak, Matej Vnucak Monika Beliancinova, Ivana Dedinska
Insulin resistance (IR) is the most significant risk factor for post-transplant diabetes mellitus (PTDM). This study aimed to determine the effects of regular physical activity on IR and PTDM in patients after kidney transplantation (KT). The study group (n = 22) participated in aerobic or combined sports (aerobic and anaerobic). Monitoring was provided by a sports tracker (Xiaomi Mi Band 4, compatible with the Mi Fit mobile application). Waist circumference was significantly lower (p = 0.0437, p = 0...
2024: Bratislavské Lekárske Listy
https://read.qxmd.com/read/38523849/a-woman-with-hnf1a-associated-monogenic-diabetes-treated-successfully-with-repaglinide-monotherapy
#5
Katherine Cuan, Ilana R Bass
BACKGROUND/OBJECTIVE: Monogenic diabetes is a rare type of diabetes that is commonly misdiagnosed as type 1 or 2 diabetes mellitus, which adversely impacts patient care. Such cases are particularly challenging given the heterogeneity in presentation and overlap with other types of diabetes. As the sole use of meglitinides, especially repaglinide, to treat HNF1A -associated monogenic diabetes has been rarely reported in a few other observational studies, we describe a patient who was treated successfully with repaglinide...
2024: AACE Clinical Case Reports
https://read.qxmd.com/read/38519028/role-of-teplizumab-a-humanized-anti-cd3-monoclonal-antibody-in-managing-newly-diagnosed-type-1-diabetes-an-updated-systematic-review-and-meta-analysis
#6
JOURNAL ARTICLE
A B M Kamrul-Hasan, Sunetra Mondal, Lakshmi Nagendra, Ashmita Yadav, Fatema Tuz Zahura Aalpona, Deep Dutta
BACKGROUND: Teplizumab has emerged as a potential disease-modifying drug in type 1 diabetes (T1D). This meta-analysis sought to summarize the therapeutic effect of teplizumab in newly diagnosed patients with T1D. METHODS: Randomized controlled trials (RCTs) involving patients with T1D receiving teplizumab in the intervention arm and placebo (or no active intervention) in the control arm were searched throughout the electronic databases. The primary outcome was the change in area under the curve (AUC) of C-peptide levels from baseline...
March 20, 2024: Endocrine Practice
https://read.qxmd.com/read/38517864/repressing-mir-23a-promotes-the-transdifferentiation-of-pancreatic-%C3%AE-cells-to-%C3%AE-cells-via-negatively-regulating-the-expression-of-sdf-1%C3%AE
#7
JOURNAL ARTICLE
Hongmei Lang, Ning Lin, Xiaorong Chen, Jie Xiang, Xingping Zhang, Chao Kang
Pancreatic β-cell failure is a pathological feature in type 1 diabetes. One promising approach involves inducing transdifferentiation of related pancreatic cell types, specifically α cells that produce glucagon. The chemokine stromal cell-derived factor-1 alpha (SDF-1α) is implicated in pancreatic α-to-β like cell transition. Here, the serum level of SDF-1α was lower in T1D with C-peptide loss, the miR-23a was negatively correlated with SDF-1α. We discovered that exosomal miR-23a, secreted from β cells, functionally downregulates the expression of SDF-1α, leading to increased Pax4 expression and decreased Arx expression in vivo...
2024: PloS One
https://read.qxmd.com/read/38517484/the-innodia-type-1-diabetes-natural-history-study-a-european-cohort-of-newly-diagnosed-children-adolescents-and-adults
#8
JOURNAL ARTICLE
M Loredana Marcovecchio, A Emile J Hendriks, Carl Delfin, Tadej Battelino, Thomas Danne, Mark L Evans, Jesper Johannesen, Simranjeet Kaur, Mikael Knip, Lut Overbergh, Flemming Pociot, John A Todd, Bart Van der Schueren, Linda S Wicker, Mark Peakman, Chantal Mathieu
AIMS/HYPOTHESIS: Type 1 diabetes is an heterogenous condition. Characterising factors explaining differences in an individual's clinical course and treatment response will have important clinical and research implications. Our aim was to explore type 1 diabetes heterogeneity, as assessed by clinical characteristics, autoantibodies, beta cell function and glycaemic outcomes, during the first 12 months from diagnosis, and how it relates to age at diagnosis. METHODS: Data were collected from the large INNODIA cohort of individuals (aged 1...
March 22, 2024: Diabetologia
https://read.qxmd.com/read/38510703/multi-omics-subgroups-associated-with-glycaemic-deterioration-in-type-2-diabetes-an-imi-rhapsody-study
#9
JOURNAL ARTICLE
Shiying Li, Iulian Dragan, Van Du T Tran, Chun Ho Fung, Dmitry Kuznetsov, Michael K Hansen, Joline W J Beulens, Leen M 't Hart, Roderick C Slieker, Louise A Donnelly, Mathias J Gerl, Christian Klose, Florence Mehl, Kai Simons, Petra J M Elders, Ewan R Pearson, Guy A Rutter, Mark Ibberson
INTRODUCTION: Type 2 diabetes (T2D) onset, progression and outcomes differ substantially between individuals. Multi-omics analyses may allow a deeper understanding of these differences and ultimately facilitate personalised treatments. Here, in an unsupervised "bottom-up" approach, we attempt to group T2D patients based solely on -omics data generated from plasma. METHODS: Circulating plasma lipidomic and proteomic data from two independent clinical cohorts, Hoorn Diabetes Care System (DCS) and Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS), were analysed using Similarity Network Fusion...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38510652/evaluating-the-effectiveness-of-a-novel-somatostatin-receptor-2-antagonist-zt-01-for-hypoglycemia-prevention-in-a-rodent-model-of-type-2-diabetes
#10
JOURNAL ARTICLE
Ninoschka C D'Souza, Julian A Aiken, Emily G Hoffman, Sara C Atherley, Sabrina Champsi, Nadia Aleali, Dorsa Shakeri, Maya El-Zahed, Nicky Akbarian, Mehran Nejad-Mansouri, Parinaz Z Bavani, Richard L Liggins, Owen Chan, Michael C Riddell
Background: Elevated levels of somatostatin blunt glucagon counterregulation during hypoglycemia in type 1 diabetes (T1D) and this can be improved using somatostatin receptor 2 (SSTR2) antagonists. Hypoglycemia also occurs in late-stage type 2 diabetes (T2D), particularly when insulin therapy is initiated, but the utility of SSTR2 antagonists in ameliorating hypoglycemia in this disease state is unknown. We examined the efficacy of a single-dose of SSTR2 antagonists in a rodent model of T2D. Methods: High-fat fed (HFF), low dose streptozotocin (STZ, 35 mg/kg)-induced T2D and HFF only, nondiabetic (controls-no STZ) rats were treated with the SSTR2 antagonists ZT-01/PRL-2903 or vehicle ( n = 9-11/group) 60 min before an insulin tolerance test (ITT; 2-12 U/kg insulin aspart) or an oral glucose tolerance test (OGTT; 2 g/kg glucose via oral gavage) on separate days...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38506952/comparison-of-beta-cell-function-and-insulin-sensitivity-between-normal-weight-and-obese-chinese-with-young-onset-type-2-diabetes
#11
JOURNAL ARTICLE
Yingnan Fan, Elaine Chow, Cadmon K P Lim, Yong Hou, Sandra T F Tsoi, Baoqi Fan, Eric S H Lau, Alice P S Kong, Ronald C W Ma, Hongjiang Wu, Juliana C N Chan, Andrea O Y Luk
Normal-weight individuals with usual-onset type 2 diabetes had reduced beta-cell function and greater insulin sensitivity compared to their obese counterparts. The relative contribution of beta-cell dysfunction and insulin resistance to young-onset type 2 diabetes (YOD) among normal-weight individuals is not well established. In 44 individuals with YOD (24 normal-weight and 20 obese) and 24 healthy controls with normoglycemia (12 normal-weight and 12 obese), we conducted 2-h 12mmol/L hyperglycemic clamps to measure acute (0-10 minute) and steady-state (100-120 minute) insulin and C-peptide responses, and insulin sensitivity index...
March 20, 2024: Diabetes
https://read.qxmd.com/read/38503115/classification-of-type-1-diabetes-a-pathogenic-and-treatment-based-classification
#12
JOURNAL ARTICLE
Shivani K Patel, Spiros Fourlanos, Jerry R Greenfield
AIM: To improve the diagnosis and classification of patients who fail to satisfy current type 1 diabetes diagnostic criteria. METHODS: Review of the literature and current diagnostic guidelines. DISCUSSION: We propose a novel, clinically useful classification based on islet autoantibody status and non-fasting C-peptide levels. Notably, we discuss the subgroup of latent autoimmune diabetes in the young and propose a new subgroup classification of autoantibody negative type 1 diabetes in remission...
March 14, 2024: Diabetes & Metabolic Syndrome
https://read.qxmd.com/read/38502365/pregnancy-and-delivery-in-an-advanced-cancer-survivor-with-immune-checkpoint-inhibitor-induced-type-1-diabetes-a-case-report
#13
JOURNAL ARTICLE
Keiji Sugai, Takashi Miwa, Junya Kojima, Yuri Ueda, Kiyoaki Tsukahara, Hirotaka Nishi, Ryo Suzuki
PURPOSE: Given the rarity and elderly onset of immune checkpoint inhibitor (ICI)-induced type 1 diabetes (ICI-T1DM), cases leading to delivery are rare. METHOD: To our knowledge, this is the first case report of childbirth in a patient with ICI-T1DM after cancer survival. A 32-year-old woman was started on Nivolumab for metastatic parotid cancers one year after total parotidectomy. RESULT: The patient developed ICI-T1DM after 43 cycles and started multiple daily insulin therapy and self-monitoring of blood glucose...
March 19, 2024: Endocrine
https://read.qxmd.com/read/38495967/extensive-disease-small-cell-lung-cancer-with-severe-immune-related-adverse-events-due-to-atezolizumab-maintaining-a-complete-response-for-two-years-a-case-report
#14
Sayaka Kudo, Keiki Yokoo, Nao Tanaka, Gen Yamada, Yasuo Kitamura
A 75-year-old male with diabetes mellitus was referred to our hospital with an abnormal shadow on chest radiography, based on which he was diagnosed with extensive-disease small-cell lung cancer (ED-SCLC; cT2bN2M1a). The first-line therapy comprised atezolizumab, carboplatin, and etoposide. After four cycles, the patient achieved complete response (CR), and maintenance therapy was initiated with atezolizumab. However, even though CR was maintained, maintenance therapy was discontinued after 16 cycles due to persistent grade 2 anorexia and fatigue...
March 2024: Curēus
https://read.qxmd.com/read/38492104/association-of-polymorphic-variants-of-tcf7l2-and-pparg-genes-with-metabolic-markers-in-patients-with-early-disorders-of-carbohydrate-metabolism
#15
JOURNAL ARTICLE
D N Isakova, S N Kolomeichuk, Yu A Petrova, M V Lyapina, I A Troshina, K A Voronin, I M Petrov
We performed complex analysis of the association of polymorphic variants rs7903146 of the TCF7L2 gene and rs1801282 of the PPARG gene with metabolic parameters, insulin resistance, and β-cell function in a group of patients with early signs of carbohydrate metabolism disturbances in a sample of Tyumen citizens. The study group consisted of 64 people (39 women, 25 men) aged 40-70 years. The distribution of frequencies of alleles and genotypes of the polymorphic markers rs7903146 and rs1801282 was analyzed and associations of carriage of major homozygous polymorphisms with various phenotypic traits were identified...
March 16, 2024: Bulletin of Experimental Biology and Medicine
https://read.qxmd.com/read/38489692/geriatric-nutritional-risk-index-is-correlated-with-islet-function-but-not-insulin-resistance-in-elderly-patients-with-type-2-diabetes-a-retrospective-study
#16
JOURNAL ARTICLE
Nan Geng, Yaxue Gao, Yuanyuan Ji, Yingchun Niu, Cuijuan Qi, Yunfeng Zhen, Jinhu Chen, Luping Ren
The geriatric nutritional risk index (GNRI) is a simple nutritional assessment tool that can predict poor prognosis in elderly subjects. The aim of this study was to evaluate the association between GNRI and both islet function and insulin sensitivity in patients with type 2 diabetes mellitus. This research carries significant implications for the integrated treatment and nutritional management of this patient population. A total of 173 patients with type 2 diabetes mellitus, aged 60 years or older, who were hospitalized in the Endocrinology Department at Hebei General Hospital from February 2018 to June 2021, were selected as the research subjects...
March 15, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38486097/gestational-diabetes-mellitus-hypertension-and-dyslipidemia-as-the-risk-factors-of-preeclampsia
#17
JOURNAL ARTICLE
Farah Aziz, Mohammad Fareed Khan, Amna Moiz
Gestational diabetes mellitus (GDM) is a known risk factor for gestational hypertension which further progress toward conditions like proteinuria, dyslipidemia, thrombocytopenia, pulmonary edema leading to Preeclampsia (PE). Pregnancy can be a challenging time for many women, especially those diagnosed with GDM and PE. Thus, the current prospective study investigates the association of OGTT glucose levels with systolic and diastolic blood pressure and lipid profile parameters in pregnant women diagnosed with GDM and PE...
March 14, 2024: Scientific Reports
https://read.qxmd.com/read/38481208/secretion-of-glucagon-glp-1-and-gip-may-be-affected-by-circadian-rhythm-in-healthy-males
#18
JOURNAL ARTICLE
Dorte B Zilstorff, Michael M Richter, Jens Hannibal, Henrik L Jørgensen, Henriette P Sennels, Nicolai J Wewer Albrechtsen
BACKGROUND: Glucagon is secreted from pancreatic alpha cells in response to low blood glucose and increases hepatic glucose production. Furthermore, glucagon enhances hepatic protein and lipid metabolism during a mixed meal. Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are secreted from gut endocrine cells during meals and control glucose homeostasis by potentiating insulin secretion and inhibiting food intake. Both glucose homeostasis and food intake have been reported to be affected by circadian rhythms and vice versa...
March 14, 2024: BMC Endocrine Disorders
https://read.qxmd.com/read/38476778/a-rare-cause-of-hypoglycemia-in-elderly-patients-insulinoma
#19
Ahmet Baris Dirim, Ahmet Seker
Insulinoma is the most common pancreatic neuroendocrine tumor and is often solitary and benign. To make a diagnosis, high insulin levels must be demonstrated, and proinsulin and C-peptide measurements must be done. The presence of hypoglycemic measurements and symptoms in the 72-hour fasting test is diagnostic. We present a case of a 91-year-old patient with no known diagnosis of diabetes mellitus who was admitted to the emergency department due to confusion. As a result of the clinical evaluation and differential diagnosis, it was determined that her complaint was due to hypoglycemia, and she was admitted to the internal medicine service for further examination, diagnosis, and treatment...
February 2024: Curēus
https://read.qxmd.com/read/38471012/gut-microbiota-tryptophan-metabolism-glp-1-axis-participates-in-%C3%AE-cell-regeneration-induced-by-dapagliflozin
#20
JOURNAL ARTICLE
Yafei Jiang, Jin Yang, Li Xia, Tianjiao Wei, Xiaona Cui, Dandan Wang, Zirun Jin, Xiafang Lin, Fei Li, Kun Yang, Shan Lang, Ye Liu, Jing Hang, Zhe Zhang, Tianpei Hong, Rui Wei
Sodium-glucose co-transporter 2 (SGLT2) inhibitor, an efficacious anti-diabetic agent, which has cardiovascular and renal benefits, can promote pancreatic β-cell regeneration in type 2 diabetic mice. However, the underlying mechanism remains unclear. In this study, we aimed to use multi-omics to identify the mediators involved in β-cell regeneration induced by dapagliflozin. We showed that dapagliflozin lowered blood glucose level, upregulated plasma insulin level, and increased islet area in db/db mice...
March 12, 2024: Diabetes
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