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https://www.readbyqxmd.com/read/28335018/dissecting-gamma-frequency-activity-during-human-memory-processing
#1
Michal T Kucewicz, Brent M Berry, Vaclav Kremen, Benjamin H Brinkmann, Michael R Sperling, Barbara C Jobst, Robert E Gross, Bradley Lega, Sameer A Sheth, Joel M Stein, Sandthitsu R Das, Richard Gorniak, S Matthew Stead, Daniel S Rizzuto, Michael J Kahana, Gregory A Worrell
Gamma frequency activity (30-150 Hz) is induced in cognitive tasks and is thought to reflect underlying neural processes. Gamma frequency activity can be recorded directly from the human brain using intracranial electrodes implanted in patients undergoing treatment for drug-resistant epilepsy. Previous studies have independently explored narrowband oscillations in the local field potential and broadband power increases. It is not clear, however, which processes contribute to human brain gamma frequency activity, or their dynamics and roles during memory processing...
March 13, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28269579/development-of-semi-chronic-microdrive-system-for-large-scale-circuit-mapping-in-macaque-mesolimbic-and-basal-ganglia-systems
#2
Shaoyu Qiao, Kevin A Brown, Amy L Orsborn, Breonna Ferrentino, Bijan Pesaran
The development of novel neurotechnologies for treating refractory neuropsychiatry disorders depends on understanding and manipulating the dynamics of neural circuits across large-scale brain networks. The mesolimbic pathway plays an essential role in reward processing and mood regulation and disorders of this pathway underlie many neuropsychiatric disorders. Here, we present the design of a customized semi-chronic microdrive array that precisely targets the anatomical structures of non-human primate (NHP) mesolimbic and basal ganglia systems...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28269266/neuronix-enables-continuous-simultaneous-neural-recording-and-electrical-microstimulation
#3
Zhi Yang, Jian Xu, Anh Tuan Nguyen, Tong Wu, Wenfeng Zhao, Wing-Kin Tam
This paper reports a novel neurotechnology (Neuronix) and its validation through experiments. It is a miniature system-on-chip (SoC) that allows recording with simultaneous electrical microstimulation. This function has not been demonstrated before and enables precise, closed-loop neuromodulation. Neuronix represents recent advancement in brain technology and applies to both animal research and clinical applications.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227834/development-of-semi-chronic-microdrive-system-for-large-scale-circuit-mapping-in-macaque-mesolimbic-and-basal-ganglia-systems
#4
Shaoyu Qiao, Kevin A Brown, Amy L Orsborn, Breonna Ferrentino, Bijan Pesaran, Shaoyu Qiao, Kevin A Brown, Amy L Orsborn, Breonna Ferrentino, Bijan Pesaran, Shaoyu Qiao, Amy L Orsborn, Breonna Ferrentino, Kevin A Brown, Bijan Pesaran
The development of novel neurotechnologies for treating refractory neuropsychiatry disorders depends on understanding and manipulating the dynamics of neural circuits across large-scale brain networks. The mesolimbic pathway plays an essential role in reward processing and mood regulation and disorders of this pathway underlie many neuropsychiatric disorders. Here, we present the design of a customized semi-chronic microdrive array that precisely targets the anatomical structures of non-human primate (NHP) mesolimbic and basal ganglia systems...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227500/neuronix-enables-continuous-simultaneous-neural-recording-and-electrical-microstimulation
#5
Zhi Yang, Jian Xu, Anh Tuan Nguyen, Tong Wu, Wenfeng Zhao, Wing-Kin Tam, Zhi Yang, Jian Xu, Anh Tuan Nguyen, Tong Wu, Wenfeng Zhao, Wing-Kin Tam, Zhi Yang, Anh Tuan Nguyen, Jian Xu, Tong Wu, Wenfeng Zhao, Wing-Kin Tam
This paper reports a novel neurotechnology (Neuronix) and its validation through experiments. It is a miniature system-on-chip (SoC) that allows recording with simultaneous electrical microstimulation. This function has not been demonstrated before and enables precise, closed-loop neuromodulation. Neuronix represents recent advancement in brain technology and applies to both animal research and clinical applications.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28198703/implantable-optoelectronic-probes-for-in-vivo-optogenetics
#6
Ege Iseri, Duygu Kuzum
More than a decade has passed since optics and genetics came together and lead to the emerging technologies of optogenetics. The advent of light-sensitive opsins made it possible to optically trigger the neurons into activation or inhibition by using visible light. The importance of spatiotemporally isolating a segment of a neural network and controlling nervous signaling in a precise manner has driven neuroscience researchers and engineers to invest great efforts in designing high precision in vivo implantable devices...
February 15, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28129140/committing-to-memory-memory-prosthetics-show-promise-in-helping-those-with-neurodegenerative-disorders
#7
Michele Solis
Cell phone chimes, sticky notes, even the proverbial string around a finger-these timehonored external cues help guard against our inevitable memory lapses. But some internal help to the brain itself may be on the way in the form of what's being called memory prosthetics. Once considered to be on the fringes of neuroscience, the idea of adding hardware to the brain to help with memory has gathered steam. In 2014, the U.S. Defense Advanced Research Projects Agency (DARPA) made a US$30 million investment in memory prosthetic research as part of the Obama administration's Brain Research through Advancing Innovative Neurotechnologies initiative...
January 2017: IEEE Pulse
https://www.readbyqxmd.com/read/28113241/m3ba-a-mobile-modular-multimodal-biosignal-acquisition-architecture-for-miniaturized-eeg-nirs-based-hybrid-bci-and-monitoring
#8
Alexander von Luhmann, Heidrun Wabnitz, Tilmann Sander, Klaus-Robert Muller
OBJECTIVE: For the further development of the fields of telemedicine, neurotechnology and Brain-Computer Interfaces (BCI), advances in hybrid multimodal signal acquisition and processing technology are invaluable. Currently, there are no commonly available hybrid devices combining bio-electrical and bio-optical neurophysiological measurements (here Electroencephalography (EEG) and functional Near Infrared Spectroscopy (fNIRS)). Our objective was the design of such an instrument, and that in a miniaturized, customizable and wireless form...
September 9, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28030932/usage-of-perioperative-anxiety-neuromarker-for-improving-the-quality-of-life-of-a-patient-operated-on-for-critical-stenosis-of-the-internal-carotid-artery
#9
Mariusz Trystuła, Paweł Półrola, Juri Kropotov
OBJECTIVE: The aim of the study was to find a neuromarker of perioperative anxiety in a patient with critical carotid stenosis through the use of neuromarkers in Quantitative EEG (QEEG) and Event Related Potentials (ERPs). The indirect purpose of the research was evaluation of improvement in the patient's quality of life. CASE STUDY: A 45-year-old woman was admitted to the Department of Vascular Surgery and Endovascular Interventions at the John Paul II Hospital in Krakow, with the diagnosis of critical internal carotid stenosis (over 80%), confirmed by Doppler Ultrasound and Angio-CT examinations...
December 23, 2016: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28009249/manipulating-memories-the-ethics-of-yesterday-s-science-fiction-and-today-s-reality
#10
Julie M Robillard, Judy Illes
The paper addresses recent advances in memory manipulation from the perspective of the four key pillars of neuroethics: the self, social policy, neurotechnology, and education and outreach. We provide examples for each pillar, assess their neuroethical implications, and conclude with a call for an ethics framework that is specifically tailored for the ethical challenges of memory manipulation.
December 1, 2016: AMA Journal of Ethics
https://www.readbyqxmd.com/read/27979758/a-testbed-for-optimizing-electrodes-embedded-in-the-skull-or-in-artificial-skull-replacement-pieces-used-after-injury
#11
JingLe Jiang, Amar R Marathe, Jennifer C Keene, Dawn M Taylor
BACKGROUND: Custom-fitted skull replacement pieces are often used after a head injury or surgery to replace damaged bone. Chronic brain recordings are beneficial after injury/surgery for monitoring brain health and seizure development. Embedding electrodes directly in these artificial skull replacement pieces would be a novel, low-risk way to perform chronic brain monitoring in these patients. Similarly, embedding electrodes directly in healthy skull would be a viable minimally-invasive option for many other neuroscience and neurotechnology applications requiring chronic brain recordings...
February 1, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/27930909/fda-regulation-of-neurological-and-physical-medicine-devices-access-to-safe-and-effective-neurotechnologies-for-all-americans
#12
Leigh Anderson, Patrick Antkowiak, Aden Asefa, Amber Ballard, Tushar Bansal, Ayo Bello, Bernard Berne, Kristen Bowsher, Bennett Blumenkopf, Ian Broverman, Mohamad Bydon, Kuo Chao, Peter Como, Karlene Cork, Ann Costello, Kathryn De Laurentis, Angela DeMarco, Heather Dean, John Doucet, Bradley Dworak, Lisa Epperson, Eric Franca, Naz Ghassemian, Chandramallika Ghosh, Anupama Govindarajan, Jay Gupta, Stacie Gutowski, Robert Herrmann, Michael Hoffmann, William Heetderks, Steven Hsu, Daryl Kaufman, Erin Keegan, Gregg Kittlesen, Kevin Khuu, Hyung Lee, Larry Lo, Ian Marcus, Timothy Marjenin, Binoy Mathews, Sanjay Misra, Vivek Pinto, Vesper Ramos, Samuel Raben, Avena Russell, Devjani Saha, Joonil Seog, Christian Shenouda, Myra Smith, Xiaorui Tang, Kelliann Wachrathit, Jaime Waterhouse, Dhanya Williams, Xiaolin Zheng, Carlos Peña
The United States Food and Drug Administration (FDA) ensures that patients in the U.S. have access to safe and effective medical devices. The Division of Neurological and Physical Medicine Devices reviews medical technologies that interface with the nervous system. This article addresses how to navigate the FDA's regulatory landscape to successfully bring medical devices to patients.
December 7, 2016: Neuron
https://www.readbyqxmd.com/read/27917107/the-berlin-brain-computer-interface-progress-beyond-communication-and-control
#13
REVIEW
Benjamin Blankertz, Laura Acqualagna, Sven Dähne, Stefan Haufe, Matthias Schultze-Kraft, Irene Sturm, Marija Ušćumlic, Markus A Wenzel, Gabriel Curio, Klaus-Robert Müller
The combined effect of fundamental results about neurocognitive processes and advancements in decoding mental states from ongoing brain signals has brought forth a whole range of potential neurotechnological applications. In this article, we review our developments in this area and put them into perspective. These examples cover a wide range of maturity levels with respect to their applicability. While we assume we are still a long way away from integrating Brain-Computer Interface (BCI) technology in general interaction with computers, or from implementing neurotechnological measures in safety-critical workplaces, results have already now been obtained involving a BCI as research tool...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27852344/neuroscience-fiction-as-eidol%C3%A3-social-reflection-and-neuroethical-obligations-in-depictions-of-neuroscience-in-film
#14
Rachel Wurzman, David Yaden, James Giordano
Neuroscience and neurotechnology are increasingly being employed to assess and alter cognition, emotions, and behaviors, and the knowledge and implications of neuroscience have the potential to radically affect, if not redefine, notions of what constitutes humanity, the human condition, and the "self." Such capability renders neuroscience a compelling theme that is becoming ubiquitous in literary and cinematic fiction. Such neuro-SciFi (or "NeuroS/F") may be seen as eidolá: a created likeness that can either accurately-or superficially, in a limited way-represent that which it depicts...
November 17, 2016: Cambridge Quarterly of Healthcare Ethics: CQ: the International Journal of Healthcare Ethics Committees
https://www.readbyqxmd.com/read/27845682/should-violent-offenders-be-forced-to-undergo-neurotechnological-treatment-a-critical-discussion-of-the-freedom-of-thought-objection
#15
Thomas Søbirk Petersen, Kristian Kragh
In this paper we examine one reason for rejecting the view that violent offenders should be forced to undergo neurotechnological treatments (NTs) involving such therapies as psychoactive medication to curb violent behaviour. The reason is based on the concern that forced treatment violates the offender's right to freedom of thought. We argue that this objection can be challenged. First, we present some specifications of what a right to freedom of thought might mean. We focus on the recently published views of Jared Craig, and Jan Cristopher Bublitz and Reinhard Merkel...
January 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/27814514/on-the-necessity-of-ethical-guidelines-for-novel-neurotechnologies
#16
Sara Goering, Rafael Yuste
Because novel neurotechnologies may alter human identity and society in profound ways, we advocate for the early integration of ethics into neurotechnology. We recommend developing and adopting a set of guidelines, like the Belmont Report on human subject research, as a framework for development and use of brain-related technologies.
November 3, 2016: Cell
https://www.readbyqxmd.com/read/27810013/view-from-silicon-valley-maximizing-the-scientific-impact-of-global-brain-initiatives-through-entrepreneurship
#17
Pushkar S Joshi, Kunal K Ghosh
In this era of technology-driven global neuroscience initiatives, the role of the neurotechnology industry remains woefully ambiguous. Here, we explain why industry is essential to the success of these global initiatives, and how it can maximize the scientific impact of these efforts by (1) scaling and ultimately democratizing access to breakthrough neurotechnologies, and (2) commercializing technologies as part of integrated, end-to-end solutions that accelerate neuroscientific discovery.
November 2, 2016: Neuron
https://www.readbyqxmd.com/read/27810009/neurotechnology-and-society-strengthening-responsible-innovation-in-brain-science
#18
Hermann Garden, Diana M Bowman, Sebastian Haesler, David E Winickoff
Technological advances have the potential to dramatically increase our understanding of the human brain, treat and cure injury and disease, and enhance our general well-being. While advances in neuroscience hold great promise, they also raise profound ethical, legal, and social questions. In this vein, the Organization for Economic Co-operation and Development (OECD) convened an international workshop in September 2016 to explore responsible research and innovation in brain science.
November 2, 2016: Neuron
https://www.readbyqxmd.com/read/27809998/brain-minds-a-japanese-national-brain-project-for-marmoset-neuroscience
#19
Hideyuki Okano, Erika Sasaki, Tetsuo Yamamori, Atsushi Iriki, Tomomi Shimogori, Yoko Yamaguchi, Kiyoto Kasai, Atsushi Miyawaki
Brain/MINDS (Brain Mapping by Integrated Neurotechnologies for Disease Studies) is a national brain project started by Japan in 2014. With the goal of developing the common marmoset as a model animal for neuroscience, the project aims to build a multiscale marmoset brain map, develop new technologies for experimentalists, create transgenic lines for brain disease modeling, and integrate translational findings from the clinical biomarker landscape. Brain/MINDS will collaborate with global brain projects to share technologies and resources...
November 2, 2016: Neuron
https://www.readbyqxmd.com/read/27809996/the-brain-initiative-building-strengthening-and-sustaining
#20
Christopher L Martin, Miyoung Chun
Successful federal initiatives share a focus on tangible success stories, constant input and guidance from scientists, participation by a wide range of funders, ongoing interest from policy makers, and a broad and effective communications network. By comparing these elements of the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative with other initiatives, we look at what needs to be done to sustain the BRAIN Initiative in the years to come.
November 2, 2016: Neuron
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