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https://www.readbyqxmd.com/read/29781806/the-need-for-understanding-and-engaging-the-patient-as-consumer-of-products-developed-by-neural-engineering
#1
Jennifer French, J Luis Lujan, Dawn Bardot, Emily Lauren Graczyk, Allison Hess-Dunning, Ronald J Triolo, Megan Moynahan, Winny Tan, Adeline Zbrzeski
Neural Engineering is a discipline at the intersection of neuroscience, engineering, and clinical care. Recent major efforts by government and industry aimed at bringing forth personalized therapies, increasing the potential of the neural engineering industry for future growth, eg. the National Institutes of Health (NIH) Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative and Stimulating Peripheral Activity to Relieve Conditions (SPARC) Common Fund Program, the Defense Advanced Research Projects Agency (DARPA) Electrical Prescriptions (ElectRx) and Systems-Based Neurotechnology for Emerging Therapies (SUBNETS) Programs, and the GlaxoSmithKline Bioelectric Medicines Initiative...
May 21, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29754872/editorial-overview-neurotechnologies
#2
EDITORIAL
Polina Anikeeva, Liqun Luo
No abstract text is available yet for this article.
May 10, 2018: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/29746895/low-and-high-gamma-auditory-steady-states-in-response-to-440-hz-carrier-chirp-modulated-tones-show-no-signs-of-attentional-modulation
#3
Evaldas Pipinis, Aleksandras Voicikas, Inga Griskova-Bulanova
Auditory steady-state responses (ASSRs) are increasingly used as a neurodiagnostical tool and in neurotechnological applications where it is important to test responses at different frequencies. We aimed to evaluate EEG responses to a low-frequency carrier (440 Hz) tone modulated with 500 ms chirps at 1-120 Hz and to test the ability of stimulation to highlight the low and high gamma band activity. Increasing and decreasing modulation rates were applied. Subjective pleasantness of chirps and attentional effects on ASSRs to chirps were assessed...
May 7, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29738986/neural-data-science-accelerating-the-experiment-analysis-theory-cycle-in-large-scale-neuroscience
#4
REVIEW
L Paninski, J P Cunningham
Modern large-scale multineuronal recording methodologies, including multielectrode arrays, calcium imaging, and optogenetic techniques, produce single-neuron resolution data of a magnitude and precision that were the realm of science fiction twenty years ago. The major bottlenecks in systems and circuit neuroscience no longer lie in simply collecting data from large neural populations, but also in understanding this data: developing novel scientific questions, with corresponding analysis techniques and experimental designs to fully harness these new capabilities and meaningfully interrogate these questions...
April 19, 2018: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/29729902/mind-reading-and-writing-the-future-of-neurotechnology
#5
REVIEW
Pieter R Roelfsema, Damiaan Denys, P Christiaan Klink
Recent advances in neuroscience and technology have made it possible to record from large assemblies of neurons and to decode their activity to extract information. At the same time, available methods to stimulate the brain and influence ongoing processing are also rapidly expanding. These developments pave the way for advanced neurotechnological applications that directly read from, and write to, the human brain. While such technologies are still primarily used in restricted therapeutic contexts, this may change in the future once their performance has improved and they become more widely applicable...
May 2, 2018: Trends in Cognitive Sciences
https://www.readbyqxmd.com/read/29674264/ultrasonic-modulation-of-neural-circuit-activity
#6
REVIEW
William J Tyler, Shane W Lani, Grace M Hwang
Ultrasound (US) is recognized for its use in medical imaging as a diagnostic tool. As an acoustic energy source, US has become increasingly appreciated over the past decade for its ability to non-invasively modulate cellular activity including neuronal activity. Data obtained from a host of experimental models has shown that low-intensity US can reversibly modulate the physiological activity of neurons in peripheral nerves, spinal cord, and intact brain circuits. Experimental evidence indicates that acoustic pressures exerted by US act, in part, on mechanosensitive ion channels to modulate activity...
April 16, 2018: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/29502530/successful-use-of-closed-loop-allostatic-neurotechnology-for-post-traumatic-stress-symptoms-in-military-personnel-self-reported-and-autonomic-improvements
#7
Catherine L Tegeler, Lee Gerdes, Hossam A Shaltout, Jared F Cook, Sean L Simpson, Sung W Lee, Charles H Tegeler
BACKGROUND: Military-related post-traumatic stress (PTS) is associated with numerous symptom clusters and diminished autonomic cardiovascular regulation. High-resolution, relational, resonance-based, electroencephalic mirroring (HIRREM®) is a noninvasive, closed-loop, allostatic, acoustic stimulation neurotechnology that produces real-time translation of dominant brain frequencies into audible tones of variable pitch and timing to support the auto-calibration of neural oscillations. We report clinical, autonomic, and functional effects after the use of HIRREM® for symptoms of military-related PTS...
December 22, 2017: Military Medical Research
https://www.readbyqxmd.com/read/29481106/can-psychology-walk-the-walk-of-open-science
#8
Bradford W Hesse
An "open science movement" is gaining traction across many disciplines within the research enterprise but is also precipitating consternation among those who worry that too much disruption may be hampering professional productivity. Despite this disruption, proponents of open data collaboration have argued that some of the biggest problems of the 21st century need to be solved with the help of many people and that data sharing will be the necessary engine to make that happen. In the United States, a national strategic plan for data sharing encouraged the federally funded scientific agencies to (a) publish open data for community use in discoverable, machine-readable, and useful ways; (b) work with public and civil society organizations to set priorities for data to be shared; (c) support innovation and feedback on open data solutions; and (d) continue efforts to release and enhance high-priority data sets funded by taxpayer dollars...
February 2018: American Psychologist
https://www.readbyqxmd.com/read/29423457/recent-advances-in-neural-electrode-tissue-interfaces
#9
Kevin Woeppel, Qianru Yang, Xinyan Tracy Cui
Neurotechnology is facing an exponential growth in the recent decades. Neural electrode-tissue interface research has been well recognized as an instrumental component of neurotechnology development. While satisfactory long-term performance was demonstrated in some applications, such as cochlear implants and deep brain stimulators, more advanced neural electrode devices requiring higher resolution for single unit recording or microstimulation still face significant challenges in reliability and longevity. In this article, we review the most recent findings that contribute to our current understanding of the sources of poor reliability and longevity in neural recording or stimulation, including the material failure, biological tissue response and the interplay between the two...
December 2017: Current Opinion in Biomedical Engineering
https://www.readbyqxmd.com/read/29346750/from-healthcare-to-warfare-and-reverse-how-should-we-regulate-dual-use-neurotechnology
#10
Marcello Ienca, Fabrice Jotterand, Bernice S Elger
Recent advances in military-funded neurotechnology and novel opportunities for misusing neurodevices show that the problem of dual use is inherent to neuroscience. This paper discusses how the neuroscience community should respond to these dilemmas and delineates a neuroscience-specific biosecurity framework. This neurosecurity framework involves calibrated regulation, (neuro)ethical guidelines, and awareness-raising activities within the scientific community.
January 17, 2018: Neuron
https://www.readbyqxmd.com/read/29209187/the-utility-and-use-of-neurotechnology-to-recover-consciousness-technical-and-neuroethical-considerations-in-approaching-the-hard-question-of-neuroscience
#11
Kathinka Evers, James J Giordano
No abstract text is available yet for this article.
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29202327/mesh-electronics-a-new-paradigm-for-tissue-like-brain-probes
#12
REVIEW
Guosong Hong, Xiao Yang, Tao Zhou, Charles M Lieber
Existing implantable neurotechnologies for understanding the brain and treating neurological diseases have intrinsic properties that have limited their capability to achieve chronically-stable brain interfaces with single-neuron spatiotemporal resolution. These limitations reflect what has been dichotomy between the structure and mechanical properties of living brain tissue and non-living neural probes. To bridge the gap between neural and electronic networks, we have introduced the new concept of mesh electronics probes designed with structural and mechanical properties such that the implant begins to 'look and behave' like neural tissue...
December 1, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/29120438/four-ethical-priorities-for-neurotechnologies-and-ai
#13
Rafael Yuste, Sara Goering, Blaise Agüera Y Arcas, Guoqiang Bi, Jose M Carmena, Adrian Carter, Joseph J Fins, Phoebe Friesen, Jack Gallant, Jane E Huggins, Judy Illes, Philipp Kellmeyer, Eran Klein, Adam Marblestone, Christine Mitchell, Erik Parens, Michelle Pham, Alan Rubel, Norihiro Sadato, Laura Specker Sullivan, Mina Teicher, David Wasserman, Anna Wexler, Meredith Whittaker, Jonathan Wolpaw
No abstract text is available yet for this article.
November 8, 2017: Nature
https://www.readbyqxmd.com/read/29074466/neuroprotective-assessment-of-prolonged-local-hypothermia-post-contusive-spinal-cord-injury-in-rodent-model
#14
Daniel Boon Loong Teh, Soo Min Chua, Ankshita Prasad, Ioannis Kakkos, Wenxuan Jiang, Mu Yue, Xiaogang Liu, Angelo Homayoun All
BACKGROUND CONTEXT: Although general hypothermia is recognized as a clinically applicable neuroprotective intervention, acute moderate local hypothermia post contusive spinal cord injury (SCI) is being considered a more effective approach. Previously, we have investigated the feasibility and safety of inducing prolonged local hypothermia in the central nervous system of a rodent model. PURPOSE: Here, we aimed to verify the efficacy and neuroprotective effects of 5 and 8 hours of local moderate hypothermia (30±0...
March 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29060203/dynamic-tracking-of-non-stationarity-in-human-ecog-activity
#15
Yuxiao Yang, Edward F Chang, Maryam M Shanechi
Modeling brain network dynamics is essential in understanding neural mechanisms and developing neurotechnologies such as closed-loop stimulation therapies for a wide range of neurological disorders. Brain network activity could have non-stationary and time-variant dynamics, especially when the subject's brain is monitored for a long period, e.g., using the electrocorticogram (ECoG). This non-stationarity makes the modeling of dynamics challenging. In our prior work, we developed a framework to identify time-invariant linear state-space models (SSMs) to describe both stationary spontaneous neural population dynamics and input-output (IO) neural dynamics in response to electrical stimulation...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29059845/an-unsupervised-learning-algorithm-for-multiscale-neural-activity
#16
Hamidreza Abbaspourazad, Maryam M Shanechi
Technological advances have enabled the simultaneous recording of multiscale neural activity consisting of spikes, local field potential (LFP), and electrocorticogram (ECoG). Developing models that describe the encoding of behavior within multiscale activity is essential both for understanding neural mechanisms and for various neurotechnologies such as brain-machine interfaces (BMI). Multiscale recordings consist of signals with different statistical profiles and time-scales. While encoding models have been developed for each scale of activity alone, developing statistical models that simultaneously characterize discrete spike and continuous LFP/ECoG recordings and their various time-scales is a major challenge...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29029236/first-in-human-experience-with-complete-integration-of-neuromodulation-device-within-a-customized-cranial-implant
#17
Chad R Gordon, Gabriel F Santiago, Judy Huang, Gregory K Bergey, Shuya Liu, Mehran Armand, Henry Brem, William S Anderson
BACKGROUND: Neuromodulation devices have the potential to transform modern day treatments for patients with medicine-resistant neurological disease. For instance, the NeuroPace System (NeuroPace Inc, Mountain View, California) is a Food and Drug Administration (FDA)-approved device developed for closed-loop direct brain neurostimulation in the setting of drug-resistant focal epilepsy. However, current methods require placement either above or below the skull in nonanatomic locations. This type of positioning has several drawbacks including visible deformities and scalp pressure from underneath leading to eventual wound healing difficulties, micromotion of hardware with infection, and extrusion leading to premature explantation...
October 6, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28880183/gaussian-process-autoregression-for-simultaneous-proportional-multi-modal-prosthetic-control-with-natural-hand-kinematics
#18
Michele Xiloyannis, Constantinos Gavriel, Andreas A C Thomik, A Aldo Faisal
Matching the dexterity, versatility and robustness of the human hand is still an unachieved goal in bionics, robotics and neural engineering. A major limitation for hand prosthetics lies in the challenges of reliably decoding user intention from muscle signals when controlling complex robotic hands. Most of the commercially available prosthetic hands use musclerelated signals to decode a finite number of predefined motions and some offer proportional control of open/close movements of the whole hand. Here, in contrast, we aim to offer users flexible control of individual joints of their artificial hand...
August 31, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28870357/neurostimulation-devices-for-the-treatment-of-neurologic-disorders
#19
REVIEW
Christine A Edwards, Abbas Kouzani, Kendall H Lee, Erika K Ross
Rapid advancements in neurostimulation technologies are providing relief to an unprecedented number of patients affected by debilitating neurologic and psychiatric disorders. Neurostimulation therapies include invasive and noninvasive approaches that involve the application of electrical stimulation to drive neural function within a circuit. This review focuses on established invasive electrical stimulation systems used clinically to induce therapeutic neuromodulation of dysfunctional neural circuitry. These implantable neurostimulation systems target specific deep subcortical, cortical, spinal, cranial, and peripheral nerve structures to modulate neuronal activity, providing therapeutic effects for a myriad of neuropsychiatric disorders...
September 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28756027/key-considerations-in-designing-a-speech-brain-computer-interface
#20
Florent Bocquelet, Thomas Hueber, Laurent Girin, Stéphan Chabardès, Blaise Yvert
Restoring communication in case of aphasia is a key challenge for neurotechnologies. To this end, brain-computer strategies can be envisioned to allow artificial speech synthesis from the continuous decoding of neural signals underlying speech imagination. Such speech brain-computer interfaces do not exist yet and their design should consider three key choices that need to be made: the choice of appropriate brain regions to record neural activity from, the choice of an appropriate recording technique, and the choice of a neural decoding scheme in association with an appropriate speech synthesis method...
November 2016: Journal of Physiology, Paris
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