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Carotid plaque hemorrhage

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https://www.readbyqxmd.com/read/28413549/challenges-in-a-case-of-ophthalmic-artery-aneurysm-associated-with-abnormal-internal-carotid-arteries
#1
Eduard B Dinca, Felix Brehar, Andrei Giovani, Alexandru V Ciurea
Ophthalmic artery aneurysms account for 5% of all cerebral aneurysms and are an important cause of morbidity and mortality related to subarachnoid hemorrhage. The diagnosis is often made only when the aneurysm is large enough to become symptomatic. They remain technically challenging for both neurosurgeon and interventional radiologist. We present the case of a 62-year-old woman admitted for transient loss of consciousness, followed by generalized tonic-clonic seizures. Computed tomography (CT) showed a subarachnoid hemorrhage (SAH), clinically graded as Hunt and Hess III...
January 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28412421/change-in-carotid-plaque-components-a-4-year-follow-up-study-with-serial-mr-imaging
#2
Laura Pletsch-Borba, Mariana Selwaness, Aad van der Lugt, Albert Hofman, Oscar H Franco, Meike W Vernooij
OBJECTIVES: The goal of this study was to determine how carotid plaque components (e.g., intraplaque hemorrhage [IPH], calcification, lipid core) change over time and which cardiovascular risk factors are associated with the development of each component. BACKGROUND: Carotid atherosclerotic plaque components are important markers of plaque vulnerability. How these components change and which factors lead to the development and changes in the components remain unclear...
April 10, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28388659/identification-of-neovascularization-by-contrast-enhanced-ultrasound-to-detect-unstable-carotid-stenosis
#3
Charlotte Schmidt, Thomas Fischer, Ralph-Ingo Rückert, Timm Oberwahrenbrock, Lutz Harms, Golo Kronenberg, Hagen Kunte
BACKGROUND: Plaque neovascularization accompanies local inflammation and critically contributes to plaque instability. Correct identification of intraplaque neovascularization by contrast-enhanced ultrasound (CEUS) may provide an additional risk marker in carotid stenosis. This pilot study investigates the correlation between histological evaluation of carotid plaque specimens and pre-surgery CEUS to identify neovascularization. METHODS: 17 patients with high-grade internal carotid artery (ICA) stenosis were studied...
2017: PloS One
https://www.readbyqxmd.com/read/28386172/angiotensin-ii-accelerated-vulnerability-of-carotid-plaque-in-a-cholesterol-fed-rabbit-model-assessed-with-magnetic-resonance-imaging-comparing-to-histopathology
#4
Beibei Sun, Huilin Zhao, Xiao Li, Hong Yao, Xiaosheng Liu, Qing Lu, Jieqing Wan, Jianrong Xu
This study sought to reveal the effect of angiotensin II (Ang II)-induced atherosclerotic vulnerability in rabbits and to determine whether in vivo magnetic resonance imaging (MRI) can determine the effect of Ang II on atherosclerotic development over time. In total, 24 elderly male New Zealand white rabbits underwent an intravascular balloon injury in the left common carotid artery (LCCA) and were subsequently fed a high cholesterol diet for 12 weeks. At 8 weeks, rabbits were randomly assigned to receive either Ang II (1...
March 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28367862/asymptomatic-plaques-of-lower-peripheral-arteries-and-their-association-with-cardiovascular-disease-an-autopsy-study
#5
Eriko Nakamura, Yuichiro Sato, Takashi Iwakiri, Atsushi Yamashita, Sayaka Moriguchi-Goto, Kazunari Maekawa, Toshihiro Gi, Yujiro Asada
AIM: Patients with peripheral artery disease (PAD) have a high prevalence of cardiovascular morbidity and mortality; however, majority of patients with PAD are asymptomatic. This study aimed to histologically evaluate whether asymptomatic, lower extremity artery plaques are associated with systemic atherosclerosis and the onset of cardiovascular disease (CVD) events using autopsy cases. METHODS: We histologically investigated the atherosclerotic plaques of the common iliac, common carotid, coronary, and renal arteries from 121 autopsy cases without symptoms of PAD (mean age:67...
March 31, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28360913/lectin-pathway-of-complement-activation-is-associated-with-vulnerability-of-atherosclerotic-plaques
#6
Stefano Fumagalli, Carlo Perego, Rosalia Zangari, Daiana De Blasio, Marco Oggioni, Francesca De Nigris, Francesco Snider, Peter Garred, Angela M R Ferrante, Maria-Grazia De Simoni
Inflammatory mechanisms may be involved in atherosclerotic plaque rupture. By using a novel histology-based method to quantify plaque instability here, we assess whether lectin pathway (LP) of complement activation, a major inflammation arm, could represent an index of plaque instability. Plaques from 42 consecutive patients undergoing carotid endarterectomy were stained with hematoxylin-eosin and the lipid core, cholesterol clefts, hemorrhagic content, thickness of tunica media, and intima, including or not infiltration of cellular debris and cholesterol, were determined...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28279371/carotid-plaque-lipid-content-and-fibrous-cap-status-predict-systemic-cv-outcomes-the-mri-substudy-in-aim-high
#7
Jie Sun, Xue-Qiao Zhao, Niranjan Balu, Moni B Neradilek, Daniel A Isquith, Kiyofumi Yamada, Gádor Cantón, John R Crouse, Todd J Anderson, John Huston, Kevin O'Brien, Daniel S Hippe, Nayak L Polissar, Chun Yuan, Thomas S Hatsukami
OBJECTIVES: The aim of this study was to investigate whether and what carotid plaque characteristics predict systemic cardiovascular outcomes in patients with clinically established atherosclerotic disease. BACKGROUND: Advancements in atherosclerosis imaging have allowed assessment of various plaque characteristics, some of which are more directly linked to the pathogenesis of acute cardiovascular events compared to plaque burden. METHODS: As part of the event-driven clinical trial AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglycerides: Impact on Global Health Outcomes), subjects with clinically established atherosclerotic disease underwent multicontrast carotid magnetic resonance imaging (MRI) to detect plaque tissue composition and high-risk features...
March 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28259876/asymptomatic-carotid-t1-high-intense-plaque-as-a-risk-factor-for-a-subsequent-cerebrovascular-ischemic-event
#8
Yoshitaka Kurosaki, Kazumichi Yoshida, Hitoshi Fukuda, Akira Handa, Masaki Chin, Sen Yamagata
BACKGROUND: Intraplaque hemorrhage, detected as a high-signal intensity on carotid MRI, is also strongly associated with ischemic events in symptomatic patients. However, in asymptomatic patients, the relationship of the T1-high intense plaque and the subsequent stroke is not clear. The aim of this study is to test the hypothesis that asymptomatic carotid T1-high intense plaque is a risk factor for a subsequent cerebrovascular ischemic event. METHODS: Of the 1,353 consecutive patients, who underwent head and carotid MRI as part of their annual medical check-up, the imaging quality of 13 was poor and 150 did not present for follow-up examination, thus leaving 1,190 subjects for evaluation...
March 4, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28196937/magnetic-resonance-imaging-plaque-hemorrhage-for-risk-stratification-in-carotid-artery-disease-with-moderate-risk-under-current-medical-therapy
#9
Akram A Hosseini, Richard J Simpson, Nishath Altaf, Philip M Bath, Shane T MacSweeney, Dorothee P Auer
BACKGROUND AND PURPOSE: Magnetic resonance imaging (MRI)-defined carotid plaque hemorrhage (MRIPH) can predict recurrent cerebrovascular ischemic events in severe symptomatic carotid stenosis. It is less clear whether MRIPH can improve risk stratification despite optimized medical secondary prevention in those with moderate risk. METHODS: One-hundred fifty-one symptomatic patients with 30% to 99% carotid artery stenosis (median age: 77, 60.5% men) clinically deemed to not benefit from endarterectomy were prospectively recruited to undergo MRI and clinical follow-up (mean, 22 months)...
March 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28178412/carotid-wall-imaging-with-routine-brain-mri-to-facilitate-early-detection-of-carotid-plaque-and-intraplaque-hemorrhage
#10
Hyo Sung Kwak, Hye Jin Yang, Seung Bae Hwang, Gyung Ho Chung
No abstract text is available yet for this article.
January 2017: Journal of Stroke
https://www.readbyqxmd.com/read/28110259/ipsilateral-plaques-display-higher-t1-signals-than-contralateral-plaques-in-recently-symptomatic-patients-with-bilateral-carotid-intraplaque-hemorrhage
#11
Xianling Wang, Jie Sun, Xihai Zhao, Daniel S Hippe, Thomas S Hatsukami, Jin Liu, Rui Li, Gador Canton, Yan Song, Chun Yuan
BACKGROUND AND AIMS: Prospective studies have shown a strong association between carotid intraplaque hemorrhage (IPH), detected by magnetic resonance imaging (MRI), and cerebrovascular ischemic events. However, IPH is also observed in a substantial number of asymptomatic patients. We hypothesized that there are differences in the characteristics of IPH+ plaques associated with recent symptoms, compared to IPH+ plaques not associated with recent symptoms. METHODS: Patients with recent (≤2 weeks) anterior circulation ischemic events were scanned using a standardized multisequence protocol...
February 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28071288/vulnerable-carotid-plaque-imaging-and-histopathology-without-a-dedicated-mri-receiver-coil
#12
Laura A Fitzpatrick, Nadav Berkovitz, Marlise P Dos Santos, Nevin Majeed, Rafael Glikstein, Santanu Chakraborty, John P Veinot, Grant Stotts, Alain Berthiaume, Robert Chatelain
Stroke is associated with vulnerable carotid artery plaques showing specific histopathologic features, namely a lipid-rich necrotic core, intraplaque hemorrhage, ulceration, and thin fibrous cap. While ultrasound and computed tomography (CT) can identify carotid plaques and determine the extent of stenosis, magnetic resonance imaging (MRI) provides further information regarding plaque composition and morphology. In this feasibility study, three patients with symptomatic, moderately stenosed plaques were imaged with CT angiography (CTA) and MRI (3T and 1...
April 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28045690/clinical-case-of-the-month-a-49-year-old-man-who-presents-with-left-sided-weakness-an-update-on-ischemic-stroke
#13
Najy Masri, Rikki Weems, Falon Brown, Ben Andres, Fred Lopez
A 49 year-old man with a past medical history significant for essential hypertension, hyperlipidemia, and coronary artery disease status post percutaneous coronary intervention and stent placement in the right coronary artery in 2010 presented for evaluation of left hemiplegia. He was feeling well until three hours prior to presentation, at which time he fell while walking from his bedroom into the kitchen. After falling, he noticed that his left upper and lower extremities felt weak. He denied any symptoms preceding the fall or any loss of consciousness...
November 2016: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/27973542/increased-vascularization-in-the-vulnerable-upstream-regions-of-both-early-and-advanced-human-carotid-atherosclerosis
#14
Ola Hjelmgren, Karl Gellerman, Josefin Kjelldahl, Per Lindahl, Göran M L Bergström
BACKGROUND: Vascularization of atherosclerotic plaques has been linked to plaque vulnerability. The aim of this study was to test if the vascularization was increased in upstream regions of early atherosclerotic carotid plaques and also to test if the same pattern of vascularization was seen in complicated, symptomatic plaques. METHODS: We enrolled 45 subjects with early atherosclerotic lesions for contrast enhanced ultrasound and evaluated the percentage of plaque area in a longitudinal ultrasound section which contained contrast agent...
2016: PloS One
https://www.readbyqxmd.com/read/27908279/co-existing-intracranial-and-extracranial-carotid-artery-atherosclerotic-plaques-and-recurrent-stroke-risk-a-three-dimensional-multicontrast-cardiovascular-magnetic-resonance-study
#15
Yilan Xu, Chun Yuan, Zechen Zhou, Le He, Donghua Mi, Rui Li, Yuanyuan Cui, Yilong Wang, Yongjun Wang, Gaifen Liu, Zhuozhao Zheng, Xihai Zhao
BACKGROUND: As a systemic disease, atherosclerosis commonly affects intracranial and extracranial carotid arteries simultaneously which is defined as co-existing plaques. Previous studies demonstrated that co-existing atherosclerotic diseases are significantly associated with ischemic cerebrovascular events. The aim of this study was to investigate the characteristics of co-existing intracranial and extracranial carotid atherosclerotic plaques and their relationships with recurrent stroke by using 3D multi-contrast magnetic resonance (MR) vessel wall imaging...
December 2, 2016: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/27878405/a-comparison-study-between-3d-t2-weighted-space-and-conventional-2d-t2-weighted-turbo-spin-echo-in-assessment-of-carotid-plaque
#16
Peng Lv, Yuanyuan Dai, Jiang Lin, Weisheng Zhang, Hao Liu, Hui Liu, Xiao Tang
The aim of this study was to compare 3D T2-weighted sampling perfection with application optimized contrast using different flip angle evolutions (T2w SPACE) with conventional 2D T2w turbo-spin echo (TSE) in plaque imaging of carotid artery. 45 patients underwent 3.0-T MRI for carotid arteries imaging. MR sequences included T2w SPACE, T2w TSE, Time of flight (TOF) and T1-weighted (T1w) TSE. The signal intensity of intra-plaque hemorrhage (IPH), lipid-rich necrotic core (LRNC), and loose matrix (LM) were measured and their contrast ratios (CRs) against adjacent muscle were calculated...
November 22, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27864523/carotid-artery-web-and-ischemic-stroke-a-case-control-study
#17
Jonathan M Coutinho, Sheldon Derkatch, Alphonse R J Potvin, George Tomlinson, Leanne K Casaubon, Frank L Silver, Daniel M Mandell
OBJECTIVE: To determine whether there is an association between carotid artery web and ischemic stroke. METHODS: This was a single-center, age- and sex-matched, case-control study. Cases were consecutive patients with anterior circulation ischemic stroke of undetermined etiology (Trial of Org 10172 in Acute Stroke Treatment [TOAST] classification). Controls were consecutive patients with cerebral aneurysms, arteriovenous malformations, or primary intracerebral hemorrhages...
January 3, 2017: Neurology
https://www.readbyqxmd.com/read/27806835/determinants-of-carotid-atherosclerotic-plaque-burden-in-a-stroke-free-population
#18
Mariana Selwaness, Reinhard Hameeteman, Ronald Van 't Klooster, Quirijn Van den Bouwhuijsen, Albert Hofman, Oscar H Franco, Wiro J Niessen, Stefan Klein, Meike W Vernooij, Aad Van der Lugt, Jolanda J Wentzel
BACKGROUND AND AIMS: In a large stroke-free population, we sought to identify cardiovascular risk factors and carotid plaque components associated with carotid plaque burden, lumen volume and stenosis. METHODS: The carotid arteries of 1562 stroke-free participants from The Rotterdam Study were imaged on a 1.5-Tesla MRI scanner. Inner and outer wall of the carotid arteries were automatically segmented and lumen volume (mm(3)), wall volume (outer wall-inner wall) and plaque burden (wall volume/outer wall volume) (%) were quantified...
December 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27796860/genetic-risk-factors-for-ischemic-and-hemorrhagic-stroke
#19
REVIEW
Ganesh Chauhan, Stéphanie Debette
Understanding the genetic risk factors for stroke is an essential step to decipher the underlying mechanisms, facilitate the identification of novel therapeutic targets, and optimize the design of prevention strategies. A very small proportion of strokes are attributable to monogenic conditions, the vast majority being multifactorial, with multiple genetic and environmental risk factors of small effect size. Genome-wide association studies and large international consortia have been instrumental in finding genetic risk factors for stroke...
December 2016: Current Cardiology Reports
https://www.readbyqxmd.com/read/27765555/magnetic-resonance-imaging-based-assessment-of-carotid-atheroma-a-comparative-study-of-patients-with-and-without-coronary-artery-disease
#20
COMPARATIVE STUDY
Ammara Usman, Umar Sadat, Zhongzhao Teng, Martin J Graves, Jonathan R Boyle, Kevin Varty, Paul D Hayes, Jonathan H Gillard
BACKGROUND: Functional magnetic resonance (MR) imaging of atheroma using contrast media enables assessment of the systemic severity of atherosclerosis in different arterial beds. Whether black-blood imaging has similar ability remains widely unexplored. In this study, we evaluate whether black-blood imaging can differentiate carotid plaques of patients with and without coronary artery disease (CAD) in terms of morphological and biomechanical features of plaque vulnerability, thereby allowing assessment of the systemic severity nature of atherosclerosis in different arterial beds...
February 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
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