keyword
MENU ▼
Read by QxMD icon Read
search

Carotid plaque hemorrhage

keyword
https://www.readbyqxmd.com/read/28279371/carotid-plaque-lipid-content-and-fibrous-cap-status-predict-systemic-cv-outcomes-the-mri-substudy-in-aim-high
#1
Jie Sun, Xue-Qiao Zhao, Niranjan Balu, Moni B Neradilek, Daniel A Isquith, Kiyofumi Yamada, Gádor Cantón, John R Crouse, Todd J Anderson, John Huston, Kevin O'Brien, Daniel S Hippe, Nayak L Polissar, Chun Yuan, Thomas S Hatsukami
OBJECTIVES: The aim of this study was to investigate whether and what carotid plaque characteristics predict systemic cardiovascular outcomes in patients with clinically established atherosclerotic disease. BACKGROUND: Advancements in atherosclerosis imaging have allowed assessment of various plaque characteristics, some of which are more directly linked to the pathogenesis of acute cardiovascular events compared to plaque burden. METHODS: As part of the event-driven clinical trial AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglycerides: Impact on Global Health Outcomes), subjects with clinically established atherosclerotic disease underwent multicontrast carotid magnetic resonance imaging (MRI) to detect plaque tissue composition and high-risk features...
March 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28259876/asymptomatic-carotid-t1-high-intense-plaque-as-a-risk-factor-for-a-subsequent-cerebrovascular-ischemic-event
#2
Yoshitaka Kurosaki, Kazumichi Yoshida, Hitoshi Fukuda, Akira Handa, Masaki Chin, Sen Yamagata
BACKGROUND: Intraplaque hemorrhage, detected as a high-signal intensity on carotid MRI, is also strongly associated with ischemic events in symptomatic patients. However, in asymptomatic patients, the relationship of the T1-high intense plaque and the subsequent stroke is not clear. The aim of this study is to test the hypothesis that asymptomatic carotid T1-high intense plaque is a risk factor for a subsequent cerebrovascular ischemic event. METHODS: Of the 1,353 consecutive patients, who underwent head and carotid MRI as part of their annual medical check-up, the imaging quality of 13 was poor and 150 did not present for follow-up examination, thus leaving 1,190 subjects for evaluation...
March 4, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28196937/magnetic-resonance-imaging-plaque-hemorrhage-for-risk-stratification-in-carotid-artery-disease-with-moderate-risk-under-current-medical-therapy
#3
Akram A Hosseini, Richard J Simpson, Nishath Altaf, Philip M Bath, Shane T MacSweeney, Dorothee P Auer
BACKGROUND AND PURPOSE: Magnetic resonance imaging (MRI)-defined carotid plaque hemorrhage (MRIPH) can predict recurrent cerebrovascular ischemic events in severe symptomatic carotid stenosis. It is less clear whether MRIPH can improve risk stratification despite optimized medical secondary prevention in those with moderate risk. METHODS: One-hundred fifty-one symptomatic patients with 30% to 99% carotid artery stenosis (median age: 77, 60.5% men) clinically deemed to not benefit from endarterectomy were prospectively recruited to undergo MRI and clinical follow-up (mean, 22 months)...
March 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28178412/carotid-wall-imaging-with-routine-brain-mri-to-facilitate-early-detection-of-carotid-plaque-and-intraplaque-hemorrhage
#4
Hyo Sung Kwak, Hye Jin Yang, Seung Bae Hwang, Gyung Ho Chung
No abstract text is available yet for this article.
January 2017: Journal of Stroke
https://www.readbyqxmd.com/read/28110259/ipsilateral-plaques-display-higher-t1-signals-than-contralateral-plaques-in-recently-symptomatic-patients-with-bilateral-carotid-intraplaque-hemorrhage
#5
Xianling Wang, Jie Sun, Xihai Zhao, Daniel S Hippe, Thomas S Hatsukami, Jin Liu, Rui Li, Gador Canton, Yan Song, Chun Yuan
BACKGROUND AND AIMS: Prospective studies have shown a strong association between carotid intraplaque hemorrhage (IPH), detected by magnetic resonance imaging (MRI), and cerebrovascular ischemic events. However, IPH is also observed in a substantial number of asymptomatic patients. We hypothesized that there are differences in the characteristics of IPH+ plaques associated with recent symptoms, compared to IPH+ plaques not associated with recent symptoms. METHODS: Patients with recent (≤2 weeks) anterior circulation ischemic events were scanned using a standardized multisequence protocol...
February 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28071288/vulnerable-carotid-plaque-imaging-and-histopathology-without-a-dedicated-mri-receiver-coil
#6
Laura A Fitzpatrick, Nadav Berkovitz, Marlise P Dos Santos, Nevin Majeed, Rafael Glikstein, Santanu Chakraborty, John P Veinot, Grant Stotts, Alain Berthiaume, Robert Chatelain
Stroke is associated with vulnerable carotid artery plaques showing specific histopathologic features, namely a lipid-rich necrotic core, intraplaque hemorrhage, ulceration, and thin fibrous cap. While ultrasound and computed tomography (CT) can identify carotid plaques and determine the extent of stenosis, magnetic resonance imaging (MRI) provides further information regarding plaque composition and morphology. In this feasibility study, three patients with symptomatic, moderately stenosed plaques were imaged with CT angiography (CTA) and MRI (3T and 1...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28045690/clinical-case-of-the-month-a-49-year-old-man-who-presents-with-left-sided-weakness-an-update-on-ischemic-stroke
#7
Najy Masri, Rikki Weems, Falon Brown, Ben Andres, Fred Lopez
A 49 year-old man with a past medical history significant for essential hypertension, hyperlipidemia, and coronary artery disease status post percutaneous coronary intervention and stent placement in the right coronary artery in 2010 presented for evaluation of left hemiplegia. He was feeling well until three hours prior to presentation, at which time he fell while walking from his bedroom into the kitchen. After falling, he noticed that his left upper and lower extremities felt weak. He denied any symptoms preceding the fall or any loss of consciousness...
November 2016: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/27973542/increased-vascularization-in-the-vulnerable-upstream-regions-of-both-early-and-advanced-human-carotid-atherosclerosis
#8
Ola Hjelmgren, Karl Gellerman, Josefin Kjelldahl, Per Lindahl, Göran M L Bergström
BACKGROUND: Vascularization of atherosclerotic plaques has been linked to plaque vulnerability. The aim of this study was to test if the vascularization was increased in upstream regions of early atherosclerotic carotid plaques and also to test if the same pattern of vascularization was seen in complicated, symptomatic plaques. METHODS: We enrolled 45 subjects with early atherosclerotic lesions for contrast enhanced ultrasound and evaluated the percentage of plaque area in a longitudinal ultrasound section which contained contrast agent...
2016: PloS One
https://www.readbyqxmd.com/read/27908279/co-existing-intracranial-and-extracranial-carotid-artery-atherosclerotic-plaques-and-recurrent-stroke-risk-a-three-dimensional-multicontrast-cardiovascular-magnetic-resonance-study
#9
Yilan Xu, Chun Yuan, Zechen Zhou, Le He, Donghua Mi, Rui Li, Yuanyuan Cui, Yilong Wang, Yongjun Wang, Gaifen Liu, Zhuozhao Zheng, Xihai Zhao
BACKGROUND: As a systemic disease, atherosclerosis commonly affects intracranial and extracranial carotid arteries simultaneously which is defined as co-existing plaques. Previous studies demonstrated that co-existing atherosclerotic diseases are significantly associated with ischemic cerebrovascular events. The aim of this study was to investigate the characteristics of co-existing intracranial and extracranial carotid atherosclerotic plaques and their relationships with recurrent stroke by using 3D multi-contrast magnetic resonance (MR) vessel wall imaging...
December 2, 2016: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/27878405/a-comparison-study-between-3d-t2-weighted-space-and-conventional-2d-t2-weighted-turbo-spin-echo-in-assessment-of-carotid-plaque
#10
Peng Lv, Yuanyuan Dai, Jiang Lin, Weisheng Zhang, Hao Liu, Hui Liu, Xiao Tang
The aim of this study was to compare 3D T2-weighted sampling perfection with application optimized contrast using different flip angle evolutions (T2w SPACE) with conventional 2D T2w turbo-spin echo (TSE) in plaque imaging of carotid artery. 45 patients underwent 3.0-T MRI for carotid arteries imaging. MR sequences included T2w SPACE, T2w TSE, Time of flight (TOF) and T1-weighted (T1w) TSE. The signal intensity of intra-plaque hemorrhage (IPH), lipid-rich necrotic core (LRNC), and loose matrix (LM) were measured and their contrast ratios (CRs) against adjacent muscle were calculated...
November 22, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27864523/carotid-artery-web-and-ischemic-stroke-a-case-control-study
#11
Jonathan M Coutinho, Sheldon Derkatch, Alphonse R J Potvin, George Tomlinson, Leanne K Casaubon, Frank L Silver, Daniel M Mandell
OBJECTIVE: To determine whether there is an association between carotid artery web and ischemic stroke. METHODS: This was a single-center, age- and sex-matched, case-control study. Cases were consecutive patients with anterior circulation ischemic stroke of undetermined etiology (Trial of Org 10172 in Acute Stroke Treatment [TOAST] classification). Controls were consecutive patients with cerebral aneurysms, arteriovenous malformations, or primary intracerebral hemorrhages...
January 3, 2017: Neurology
https://www.readbyqxmd.com/read/27806835/determinants-of-carotid-atherosclerotic-plaque-burden-in-a-stroke-free-population
#12
Mariana Selwaness, Reinhard Hameeteman, Ronald Van 't Klooster, Quirijn Van den Bouwhuijsen, Albert Hofman, Oscar H Franco, Wiro J Niessen, Stefan Klein, Meike W Vernooij, Aad Van der Lugt, Jolanda J Wentzel
BACKGROUND AND AIMS: In a large stroke-free population, we sought to identify cardiovascular risk factors and carotid plaque components associated with carotid plaque burden, lumen volume and stenosis. METHODS: The carotid arteries of 1562 stroke-free participants from The Rotterdam Study were imaged on a 1.5-Tesla MRI scanner. Inner and outer wall of the carotid arteries were automatically segmented and lumen volume (mm(3)), wall volume (outer wall-inner wall) and plaque burden (wall volume/outer wall volume) (%) were quantified...
December 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27796860/genetic-risk-factors-for-ischemic-and-hemorrhagic-stroke
#13
REVIEW
Ganesh Chauhan, Stéphanie Debette
Understanding the genetic risk factors for stroke is an essential step to decipher the underlying mechanisms, facilitate the identification of novel therapeutic targets, and optimize the design of prevention strategies. A very small proportion of strokes are attributable to monogenic conditions, the vast majority being multifactorial, with multiple genetic and environmental risk factors of small effect size. Genome-wide association studies and large international consortia have been instrumental in finding genetic risk factors for stroke...
December 2016: Current Cardiology Reports
https://www.readbyqxmd.com/read/27765555/magnetic-resonance-imaging-based-assessment-of-carotid-atheroma-a-comparative-study-of-patients-with-and-without-coronary-artery-disease
#14
Ammara Usman, Umar Sadat, Zhongzhao Teng, Martin J Graves, Jonathan R Boyle, Kevin Varty, Paul D Hayes, Jonathan H Gillard
BACKGROUND: Functional magnetic resonance (MR) imaging of atheroma using contrast media enables assessment of the systemic severity of atherosclerosis in different arterial beds. Whether black-blood imaging has similar ability remains widely unexplored. In this study, we evaluate whether black-blood imaging can differentiate carotid plaques of patients with and without coronary artery disease (CAD) in terms of morphological and biomechanical features of plaque vulnerability, thereby allowing assessment of the systemic severity nature of atherosclerosis in different arterial beds...
October 17, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27718372/carotid-plaque-fissure-an-underestimated-source-of-intraplaque-hemorrhage
#15
Mat J Daemen, Marina S Ferguson, Frank J Gijsen, Daniel S Hippe, M Eline Kooi, Kevin Demarco, Allard C van der Wal, Chun Yuan, Thomas S Hatsukami
BACKGROUND AND AIMS: Plaque fissuring, a phenomenon morphologically distinct from the classical rupture of a thinned fibrous cap, has not been well characterized in carotid atherosclerosis. The aim of this study was to establish the prevalence of plaque fissures in advanced carotid plaques with an otherwise intact luminal surface, and to determine whether they might be a source of intraplaque hemorrhage (IPH). METHODS: We evaluated 244 surgically intact, 'en bloc' embedded, serially sectioned carotid endarterectomy specimens and included only those plaques with a grossly intact luminal surface...
September 28, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27650877/asymptomatic-extracranial-artery-stenosis-and-the-risk-of-cardiovascular-and-cerebrovascular-diseases
#16
Dandan Wang, Jing Wang, Cheng Jin, Ruijun Ji, Anxin Wang, Xin Li, Xiang Gao, Shouling Wu, Yong Zhou, Xingquan Zhao
Asymptomatic extracranial artery stenosis (ECAS) is a well-known risk factor for stroke events, but it remains unclear whether it has the same role in predicting cardiovascular and cerebrovascular diseases, especially in China. We investigated the potential associations between ECAS, carotid plaque and carotid intima-media thickness and the new occurrence of cardiovascular and cerebrovascular diseases in the study. Out of 5440 study participants, 364 showed an asymptomatic ECAS at baseline, and 185 had come up to the final vascular events (brain infarction, intracerebral hemorrhage, subarachnoid hemorrhage, coronary heart disease and death due to the vascular diseases)...
September 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27595161/age-associated-changes-in-human-carotid-atherosclerotic-plaques
#17
Jaroslav Pelisek, Heiko Wendorff, Carina Wendorff, Andreas Kuehnl, Hans-Henning Eckstein
Little is known about changes in carotid plaque morphology during aging and the possible impact on cardiovascular events. Only few studies addressed so far age-related modifications within atherosclerotic lesions. Therefore, in this work we endeavored to summarize the current knowledge about changing of plaque composition in elderly. The data from hitherto existing studies confirm that atherosclerotic plaques undergo distinct alternations with advanced age. However, the results are often ambiguous and the changes do not seem to be as disastrous as expected...
September 5, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27556726/comparison-study-between-multicontrast-atherosclerosis-characterization-match-and-conventional-multicontrast-mri-of-carotid-plaque-with-histology-validation
#18
Yuanyuan Dai, Peng Lv, Jiang Lin, Rongkui Luo, Hao Liu, Aihua Ji, Hui Liu, Caixia Fu
PURPOSE: To compare Multicontrast ATherosclerosis Characterization (MATCH) with conventional multicontrast magnetic resonance imaging (MRI) in the characterization and quantification of carotid plaque components. MATERIALS AND METHODS: Fifty-three consecutive patients underwent carotid plaque 3.0T MRI including conventional multicontrast sequences and MATCH, with 13 of them having carotid endarterectomy for histology validation. The detection of major plaque components including lipid-rich necrotic core (LRNC), loose matrix (LM), intraplaque hemorrhage (IPH), and calcification (CA) and measurement of lumen area, outer wall area, normalized wall index (NWI), and plaque components areas were compared between the two protocols...
August 24, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27544892/targeted-near-infrared-fluorescence-imaging-of%C3%A2-atherosclerosis-clinical-and-intracoronary-evaluation-of-indocyanine-green
#19
Johan W Verjans, Eric A Osborn, Giovanni J Ughi, Marcella A Calfon Press, Ehsan Hamidi, Antonios P Antoniadis, Michail I Papafaklis, Mark F Conrad, Peter Libby, Peter H Stone, Richard P Cambria, Guillermo J Tearney, Farouc A Jaffer
OBJECTIVES: This study sought to determine whether indocyanine green (ICG)-enhanced near-infrared fluorescence (NIRF) imaging can illuminate high-risk histologic plaque features of human carotid atherosclerosis, and in coronary atheroma of living swine, using intravascular NIRF-optical coherence tomography (OCT) imaging. BACKGROUND: New translatable imaging approaches are needed to identify high-risk biological signatures of atheroma. ICG is a U.S. Food and Drug Administration-approved NIRF imaging agent that experimentally targets plaque macrophages and lipid in areas of enhanced endothelial permeability...
September 2016: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27540477/recent-advances-in-pathogenesis-assessment-and-treatment-of-atherosclerosis
#20
REVIEW
J David Spence
In recent years, there have been a number of advances in the pathogenesis and treatment of atherosclerosis and in assessing prognosis in carotid atherosclerosis. Risk stratification to improve vascular prevention by identifying patients most likely to benefit from intensive therapy is much improved by measuring carotid plaque burden. In patients with asymptomatic carotid stenosis, a number of modalities can be used to identify the 10-15% who could benefit from endarterectomy or stenting. Transcranial Doppler embolus detection, echolucency and ulceration on 3D ultrasound, intraplaque hemorrhage on magnetic resonance imaging (MRI), and reduced cerebrovascular reserve are useful already; new approaches including plaque texture on ultrasound and imaging of plaque inflammation and early calcification on positron emission tomography/computed tomography (PET/CT) are in development...
2016: F1000Research
keyword
keyword
12278
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"