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Palmer planter syndrome

Mark W Kieran, Susan Chi, Stewart Goldman, Arzu Onar-Thomas, Tina Young Poussaint, Sridhar Vajapeyam, Frederic Fahey, Shengjie Wu, David C Turner, Clinton F Stewart, Marsha Moses, Roger J Packer, Regina Jakacki, Anu Banerjee, James M Boyett, Maryam Fouladi, Larry Kun
BACKGROUND: Cediranib (AZD2171), an oral pan-vascular endothelial growth factor (VEGF) inhibitor, was evaluated in this phase I study to determine its toxicity profile, dose-limiting toxicities (DLTs), maximum-tolerated dose (MTD), pharmacokinetics, and pharmacodynamics in children and adolescents with recurrent or refractory primary central nervous system (CNS) tumors. METHODS: Children and adolescents <22 years were enrolled into one of two strata: stratum I—those not receiving enzyme-inducing anticonvulsant drugs (EIACD) and stratum II—those receiving EIACDs...
September 2015: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
P Subramaniam, S Mathew, K K Gupta
Papillon-Lefevre syndrome is a rare autosomal recessive genetic disorder. The clinical manifestations include palmer planter hyperkeratosis with precocious progressive periodontal disease that results in premature exfoliation of primary and permanent dentitions. Patients are often edentulous at an early age. This is a case report of prosthodontic rehabilitation of a 15-year-old girl with Papillon-Lefevre syndrome.
December 2008: Journal of the Indian Society of Pedodontics and Preventive Dentistry
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