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https://www.readbyqxmd.com/read/28108386/trajectory-of-improvement-in-children-and-adolescents-with-chronic-migraine-results-from-the-cognitive-behavioral-therapy-and-amitriptyline-trial
#1
John W Kroner, James Peugh, Susmita M Kashikar-Zuck, Susan L LeCates, Janelle R Allen, Shalonda K Slater, Marium Zafar, Marielle A Kabbouche, Hope L O'Brien, Chad E Shenk, Ashley M Kroon Van Diest, Andrew D Hershey, Scott W Powers
: We compared headache frequency trajectories between clinical trial participants who received cognitive behavioral therapy plus amitriptyline (CBT+A) or headache education plus amitriptyline (HE+A) to determine if there was differential time course of treatment response between the groups. 135 patients (age 10-17) diagnosed with chronic migraine participated, attending 8 one-hour one-on-one CBT or HE sessions with a trained psychologist for 8 weekly sessions, 2 sessions at weeks 12 and 16, and a post-treatment visit at week 20...
January 17, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28108291/neuroendocrine-signaling-modulates-specific-neural-networks-relevant-to-migraine
#2
Margarida Martins-Oliveira, Simon Akerman, Philip R Holland, Jan R Hoffmann, Isaura Tavares, Peter J Goadsby
Migraine is a disabling brain disorder involving abnormal trigeminovascular activation and sensitization. Fasting or skipping meals is considered a migraine trigger and altered fasting glucose and insulin levels have been observed in migraineurs. Therefore peptides involved in appetite and glucose regulation including insulin, glucagon and leptin could potentially influence migraine neurobiology. We aimed to determine the effect of insulin (10U·kg(-1)), glucagon (100μg·200μl(-1)) and leptin (0.3, 1 and 3mg·kg(-1)) signaling on trigeminovascular nociceptive processing at the level of the trigeminocervical-complex and hypothalamus...
January 17, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28106318/reduced-laser-evoked-potential-habituation-detects-abnormal-central-pain-processing-in-painful-radiculopathy-patients
#3
P Hüllemann, C von der Brelie, G Manthey, J Düsterhöft, A K Helmers, M Synowitz, R Baron
BACKGROUND: Repetitive painful laser stimuli lead to physiological laser-evoked potential (LEP) habituation, measurable by a decrement of the N2/P2 amplitude. The time course of LEP-habituation is reduced in the capsaicin model for peripheral and central sensitization and in patients with migraine and fibromyalgia. In the present investigation, we aimed to assess the time course of LEP-habituation in a neuropathic pain syndrome, i.e. painful radiculopathy. METHODS: At the side of radiating pain, four blocks of 25 painful laser stimuli each were applied to the ventral thigh at the L3 dermatome in 27 patients with painful radiculopathy...
January 20, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28103774/formulation-development-and-evaluation-of-lyophilized-nasal-inserts-for-migraine-treatment
#4
Atishkumar Mundada, Harshada Sarode
BACKGROUND: Nasal inserts are novel, solid, bioadhesive dosage forms administered via nasal route for prolonged systemic drug delivery. The principle of the dosage form is that, after administration nasal inserts imbibe nasal fluid from the mucosa and form a gel in the nasal cavity in order to avoid foreign body sensation. The objective of this investigation was the development of chitosan/xanthan gum based bioadhesive nasal inserts of antimigraine drug. METHODS: Lyophilization is more usual technique for the preparation of nasal inserts and it is one of the applied methods for drying of solids either in the form of aqueous solution or rarely in the form of aqueous suspension by using freeze dryers...
January 18, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/28103158/serotonin-receptor-targeted-therapy-for-migraine-treatment-an-overview-of-drugs-in-phase-i-and-ii-clinical-development
#5
P Barbanti, C Aurilia, G Egeo, L Fofi, R Palmirotta
Research has focused on serotonin (5-HT) 5-HT1D and 5-HT1F receptors to develop drugs acting through non-vasoconstrictive mechanisms for treating acute migraine and those targeting 5-HT2B and 5-HT7 receptors for preventing migraine. Areas covered: This paper reviews antimigraine drugs targeting 5-HT receptors in one phase I trial (sumatriptan iontophoretic transdermal system, TDS) and five phase II clinical trials (PNU-142633, LY334370, lasmiditan, NOX-188). Expert opinion: Data from our overview on investigational drugs in phase I and II clinical trials using the 5-HT1B/1D receptor agonist (sumatriptan TDS), 5-HT1D receptor agonist (PNU-142633), 5-HT1F receptor agonists (LY334370, lasmiditan) and a combined 5-HT1B/1D receptor agonist with nNOS inhibition (NOX-188) provided encouraging data for sumatriptan TDS and lasmiditan, disappointing results for PNU-142633, and promising findings for NOX-188...
January 19, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28101987/delivery-outcomes-of-patients-with-acute-migraine-in-pregnancy-a-retrospective-study
#6
Tracy B Grossman, Shravya Govindappagari, Ashlesha K Dayal, Matthew S Robbins
OBJECTIVE: To describe labor and delivery outcomes in pregnant patients presenting to the hospital setting with an acute severe migraine headache attack earlier in the same gestation. METHODS: We retrospectively reviewed pregnancy and delivery records from a database of consecutive inpatient neurology consultations for acute headache in pregnant women over a 5 year period. RESULTS: We identified 86 pregnant women with acute migraine. The mean age was 29...
January 18, 2017: Headache
https://www.readbyqxmd.com/read/28101762/neuropsychological-assessment-in-migraine-patients-a-descriptive-review-on-cognitive-implications
#7
REVIEW
Maria Foti, Viviana Lo Buono, Francesco Corallo, Rosanna Palmeri, Placido Bramanti, Silvia Marino
Migraine is considered a disabling disorder with highly prevalence in population. Recent studies report that migraine patients have a cognitive decline associated to structural brain alterations. We search on PubMed and Web of Science databases and screening references of included studies and review articles for additional citations. From 519 studies identified, only 16 met the inclusion criteria. All studies were conducted on 1479 migraineurs (190 non-migraine headache and 11,978 controls subject) and examined the association between migraine and cognitive impairment...
January 18, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28101529/cortico-cortical-connections-of-primary-sensory-areas-and-associated-symptoms-in-migraine
#8
Duncan J Hodkinson, Rosanna Veggeberg, Aaron Kucyi, Koene R A van Dijk, Sophie L Wilcox, Steven J Scrivani, Rami Burstein, Lino Becerra, David Borsook
Migraine is a recurring, episodic neurological disorder characterized by headache, nausea, vomiting, and sensory disturbances. These events are thought to arise from the activation and sensitization of neurons along the trigemino-vascular pathway. From animal studies, it is known that thalamocortical projections play an important role in the transmission of nociceptive signals from the meninges to the cortex. However, little is currently known about the potential involvement of cortico-cortical feedback projections from higher-order multisensory areas and/or feedforward projections from principle primary sensory areas or subcortical structures...
November 2016: ENeuro
https://www.readbyqxmd.com/read/28101484/cadasil-initially-presented-with-a-seizure
#9
Jung-Hwan Oh, Bong Su Kang, Jay Chol Choi
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary disease of the cerebral small blood vessels characterized by recurrent ischemic strokes, migraine, and progressive cognitive impairment. In patients with CADASIL, in whom subcortical white matter structures are typically involved, epileptic seizures have been rarely reported as an initial clinical symptom. We describe a patient genetically confirmed as having CADASIL who initially presented with a seizure...
December 2016: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/28101483/intermittent-theta-slowings-in-contralateral-side-of-weakness-after-sleep-deprivation-on-spot-eeg-in-sporadic-hemiplegic-migraine
#10
Chan-Hyuk Lee, Man-Wook Seo, Byoung-Soo Shin, Tae-Ho Yang, Hyun-June Shin, Han Uk Ryu
Hemiplegic migraine (HM) is an uncommon type of migraine which is classified into sporadic and familial subtype. The noticed electroencephalogram (EEG) findings during HM attack are diffuse slowing contralateral to the weakened limb, but are usually normal in asymptomatic states. A 52-year-old woman who suffered from headache accompanying right arm weakness and aphasic symptoms admitted to our hospital. She underwent total five times of EEG including 2 times before admission. Only the last EEG exam after 24 hours of sleep deprivation (SD) showed intermittent slowing and higher amplitude of positive occipital sharp transients (POSTs) on the left parieto-occipital area...
December 2016: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/28101470/protective-roles-of-n-acetyl-cysteine-and-or-taurine-against-sumatriptan-induced-hepatotoxicity
#11
Javad Khalili Fard, Hossein Hamzeiy, Mohammadreza Sattari, Mohammad Ali Eghbal
Purpose: Triptans are the drug category mostly prescribed for abortive treatment of migraine. Most recent cases of liver toxicity induced by triptans have been described, but the mechanisms of liver toxicity of these medications have not been clear. Methods: In the present study, we obtained LC50 using dose-response curve and investigated cell viability, free radical generation, lipid peroxide production, mitochondrial injury, lysosomal membrane damage and the cellular glutathione level as toxicity markers as well as the beneficial effects of taurine and/or N-acetyl cysteine in the sumatriptan-treated rat parenchymal hepatocytes using accelerated method of cytotoxicity mechanism screening...
December 2016: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28099107/case-238-spontaneous-pneumothorax-secondary-to-intrapulmonary-necrobiotic-rheumatoid-nodule
#12
Ammar A Chaudhry, Maryam Gul, Abbas A Chaudhry, William Moore
History A 54-year-old white woman with a history of rheumatoid arthritis who was taking glucocorticoids and methotrexate presented to the emergency department in December with worsening shortness of breath and chest heaviness for 1 week. She reported additional symptoms of weakness, headache, and arthralgia primarily involving her bilateral hands, wrist, ankles, and feet. She denied experiencing fevers, syncope or presyncope, focal neurologic deficits, chest pain, nausea, vomiting, unintentional weight loss, or recent trauma...
February 2017: Radiology
https://www.readbyqxmd.com/read/28098796/comparative-metabolite-profiling-of-triterpenoid-saponins-and-flavonoids-in-flower-color-mutations-of-primula-veris-l
#13
Lysanne Apel, Dietmar R Kammerer, Florian C Stintzing, Otmar Spring
Primula veris L. is an important medicinal plant with documented use for the treatment of gout, headache and migraine reaching back to the Middle Ages. Triterpenoid saponins from roots and flowers are used in up-to-date phytotherapeutic treatment of bronchitis and colds due to their expectorant and secretolytic effects. In addition to the wild type plants with yellow petals, a red variant and an intermediate orange form of Primula veris L. have recently been found in a natural habitat. The secondary metabolite profiles of roots, leaves and flowers of these rare variants were investigated and compared with the wild type metabolome...
January 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28097511/brain-calcification-and-movement-disorders
#14
REVIEW
Vladimir S Kostić, Igor N Petrović
Brain calcifications may be an incidental finding on neuroimaging in normal, particularly older individuals, but can also indicate numerous hereditary and nonhereditary syndromes, and metabolic, environmental, infectious, autoimmune, mitochondrial, traumatic, or toxic disorders. Bilateral calcifications most commonly affecting the basal ganglia may often be found in idiopathic cases, and a new term, primary familial brain calcification (PFBC), has been proposed that recognizes the genetic causes of the disorder and that calcifications occurred well beyond the basal ganglia...
January 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28097510/when-headache-warns-of-homeostatic-threat-the-metabolic-headaches
#15
REVIEW
Parneet Grewal, Jonathan H Smith
Headache attributable to disorders of homeostasis represents a diverse diagnostic category in which external (i.e., high-altitude) or internal (i.e., fasting) demands exceed homeostatic capacity, resulting in symptomatic headaches. Metabolic headaches, especially fasting headache, have been observed to be common in the general population. In many cases, a history of migraine is a risk factor, consistent with the hypothesis of an adaptive, evolutionary role of headache to warn against environmental and physiological threats...
January 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28094022/a-case-report-of-an-adolescent-with-cluster-headaches-following-neck-trauma-coincidence-or-trigger
#16
Agnieszka Biedroń, Marek Kaciński, Małgorzata Steczkowska, Anna Świerczyńska
Posttraumatic headaches usually have tension-type or migraine-like characteristics. A correlation between head trauma and cluster headaches (CH) has been previously reported. CH in children are rare and require thorough differential diagnosis. We present an original case of a 15-year-old boy with cluster headaches associated with allodynia probably evoked by a neck trauma. Severe headache attacks started one month after neck trauma. At the beginning clinical presentation of our patient's headaches was very misleading...
January 10, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28093722/triptan-use-in-australia-1997-2015-a-pharmacoepidemiological-study
#17
B L K D Eyre, M J Eadie, M L van Driel, L Ross-Lee, S A Hollingworth
OBJECTIVE: This study examined the use of triptan derivatives in Australia between 1997 and 2015, based on a national drug reimbursement database, and compared patterns of use with available international data. METHODS: We obtained publically available data on the number of prescriptions for triptans marketed in Australia (sumatriptan, eletriptan, rizatriptan, zolmitriptan, naratriptan). Dispensed use was measured as defined daily dose (DDD per 1000 population per day) for Australia's concessional beneficiaries (low-income earners, people with disabilities, and seniors)...
January 16, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28093374/predictors-of-pharmacological-intervention-in-adolescents-with-protracted-symptoms-after-sports-related-concussion
#18
Shanti M Pinto, Maria F Twichell, Luke C Henry
BACKGROUND: Though recovery after concussion is spontaneous and typically occurs within two to three weeks, a subset of adolescents develop persistent symptoms after a sports-related concussion. Medications are frequently prescribed as part of a comprehensive treatment approach to alleviate these symptoms; however, there are no guidelines for prescription of pharmacologic therapy after concussion. OBJECTIVE: To investigate common factors that are associated with the use of medications (anti-epileptic, anti-depressant, neurostimulant, or sleeping medication) during recovery from a sports-related concussion...
January 13, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28091820/depression-of-home-cage-wheel-running-a-reliable-and-clinically-relevant-method-to-assess-migraine-pain-in-rats
#19
Ram Kandasamy, Andrea T Lee, Michael M Morgan
BACKGROUND: The development of new anti-migraine treatments is limited by the difficulty inassessing migraine pain in laboratory animals. Depression of activity is one of the few diagnostic criteria formigraine that can be mimicked in rats. The goal of the present study was to test the hypothesis thatdepression of home cage wheel running is a reliable and clinically relevant method to assess migraine painin rats. METHODS: Adult female rats were implanted with a cannula to inject allyl isothiocyanate (AITC) onto the dura to induce migraine pain, as has been shown before...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28090678/the-epileptic-and-nonepileptic-spectrum-of-paroxysmal-dyskinesias-channelopathies-synaptopathies-and-transportopathies
#20
REVIEW
Roberto Erro, Kailash P Bhatia, Alberto J Espay, Pasquale Striano
Historically, the syndrome of primary paroxysmal dyskinesias was considered a group of disorders as a result of ion channel dysfunction. This proposition was primarily based on the discovery of mutations in ion channels, which caused other episodic neurological disorders such as epilepsy and migraine and also supported by the frequent association between paroxysmal dyskinesias and epilepsy. However, the discovery of the genes responsible for the 3 classic forms of paroxysmal dyskinesias disproved this ion channel theory...
January 16, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
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