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https://www.readbyqxmd.com/read/29236338/inflammatory-cytokine-and-c-reactive-protein-concentrations-in-dogs-with-systemic-inflammatory-response-syndrome
#1
Kris Gommeren, Isabelle Desmas, Alexandra Garcia, Natalie Bauer, Andreas Moritz, Joachim Roth, Dominique Peeters
OBJECTIVE: To evaluate C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) kinetics in dogs with a systemic inflammatory response syndrome (SIRS) presented to an emergency service. We hypothesized serum CRP concentrations would increase and vary during hospitalization, and would correlate with plasma IL-6 and TNF-α concentrations, vary in magnitude according to the underlying disease, and predict survival. DESIGN: Prospective, observational, clinical study...
December 13, 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/29235239/familial-risks-in-urolithiasis-in-the-population-of-sweden
#2
Kari Hemminki, Otto Hemminki, Asta Försti, Kristina Sundquist, Jan Sundquist, Xinjun Li
OBJECTIVES: To assess detailed familial risks for medically diagnosed urolithiasis (UL, urinary tract stone disease) based on nationwide hospital and population records. SUBJECTS/PATIENTS AND METHODS: Subjects were identified from the Swedish Multigeneration Register in which 211,718 UL patients. Standardized incidence ratios (SIRs) were calculated by comparison to individuals without a family history of UL. RESULTS: The highest familial SIRs were invariably found for the same (concordant) type of UL: 2...
December 13, 2017: BJU International
https://www.readbyqxmd.com/read/29235202/three-dimensional-static-articulation-accuracy-of-virtual-models-part-i-system-trueness-and-precision
#3
Sophia Hui Xin Yee, Roxanna Jean Esguerra, Amelia Anya Qin'An Chew, Keng Mun Wong, Keson Beng Choon Tan
PURPOSE: To evaluate the 3D static articulation accuracy of 3 model scanner-CAD systems (Ceramill Map400 [AG], inEos X5 [SIR], Scanner S600 Arti [ZKN]) using a coordinate measuring machine (CMM). Trueness and precision for each system will be reported in Part I. MATERIALS AND METHODS: The master model simulated a single crown opposing a 3-unit fixed dental prosthesis. Five mounted stone cast sets were prepared, and one set was randomly selected. Reference values were obtained by measuring interarch and interocclusal reference features with the CMM...
December 13, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29234999/prognostic-significance-of-serum-inflammatory-markers-in-gastric-cancer
#4
Arfon G M T Powell, Debora Parkinson, Neil Patel, David Chan, Adam Christian, Wyn G Lewis
BACKGROUND: The aim of this study was to assess the relative prognostic value of biomarkers to measure the systemic inflammatory response (SIR) and improve prognostic modeling in a cohort of patients undergoing potentially curative surgery for gastric adenocarcinoma. The hypothesis was that a single SIR biomarker would be associated with the most prognostic value. METHODS: Consecutive 331 patients undergoing surgery for gastric cancer between 2004 and 2016 within a regional UK cancer network were identified...
October 4, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29234407/jinhong-tablet-reduces-damage-of-intestinal-mucosal-barrier-in-rats-with-acute-biliary-infection-via-bcl-2-bax-mrna-and-protein-regulation
#5
Xiaoqiang Liang, Xiao Ni, YongQi Wang, Jinkun Xie, Xuelin Zhang, Honggang Gu, Jingzhe Zhang
Objective: To explore the effects and mechanism of Jinhong Tablet on intestinal mucosal barrier function and SIRS in rats with acute biliary infection. Methods: 36 SD male rats were divided into three groups: sham operation (control), acute biliary infection (ABI) model, and Jinhong Tablet (Jinhong) group. Jinhong group were force-fed with Jinhong Tablet, while the other two groups received oral saline. At days 3 and 5, morphological changes of intestinal mucosa were assessed...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29233775/an-exploration-of-the-role-of-asymptomatic-infections-in-the-epidemiology-of-dengue-viruses-through-susceptible-asymptomatic-infected-and-recovered-sair-models
#6
Martin Grunnill
It is estimated that 20-97% of all dengue infections could be asymptomatic. I used SIR models to investigate the epidemiological role of such infections, by adding an asymptomatic class (SAIR models). Upon infection in one of the models, a human becomes either symptomatic or asymptomatic. In the other, a human becomes asymptomatic and may progress to being symptomatic. The robustness of results from these models is examined by incorporating the mosquito-vector into one of the models, followed by simulating epidemic dynamics stochastically...
December 9, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29233630/higher-risk-of-renal-disease-in-chronic-hepatitis-c-patients-antiviral-therapy-survival-benefit-in-patients-on-hemodialysis
#7
Jonas Söderholm, Charlotta Millbourn, Katharina Büsch, Jan Kövamees, Robert Schvarcz, Karin Lindahl, Annette Bruchfeld
BACKGROUND & AIMS: Several studies have shown that chronic hepatitis C (CHC) infection has a negative impact on kidney function, as well as survival, in patients with chronic kidney disease (CKD) or on hemodialysis (HD). The aim of this nationwide registry study was to describe renal disease in Swedish CHC patients METHODS: In the present study, patients were identified for CHC (B18.2) and CKD (N18) according to the International Classification of Diseases (ICD)-10 in the nationwide Swedish inpatient care day surgery (1997-2013) and non-primary outpatient care (2001-2013) patient registries...
December 9, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29232452/heart-transplants-reflections-expectations-sir-magdi-yacoub-reviews-the-history-of-heart-transplantation-and-discusses-expectations
#8
Magdi Yacoub
No abstract text is available yet for this article.
December 7, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29228199/new-neoplasm-during-gh-replacement-in-adults-with-pituitary-deficiency-following-malignancy-a-kims-analysis
#9
Katarzyna Krzyzanowska-Mittermayer, Anders F Mattsson, Dominique Maiter, Ulla Feldt-Rasmussen, Cecilia Camacho-Hübner, Anton Luger, Roger Abs
Context: Data on the association between growth hormone (GH) replacement in patients with GH deficiency (GHD) after malignancies and new neoplasms show conflicting results. Objective: To clarify the incidence of new malignant neoplasm in childhood (CO) and adult-onset (AO) adult cancer survivors (CS). Design: Retrospective comparison of CO-CS and AO-CS with CO idiopathic GHD (IGHD) and AO non-functioning pituitary adenoma patients (NFPA) and with the general population (standardized incidence ratio, SIR)...
December 7, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29225208/dietary-calcium-and-serum-25ohd-protect-chinese-women-from-type-2-diabetes
#10
Lijun Feng, Zhefang Hu, Qingqing Wang
The Chinese dietary structure is different from Western and Mediterranean diets. This study aimed to assess the association of dietary calcium, serum 25-hydroxyvitamin D (25OHD), and other macronutrients with type 2 diabetes (T2D) in Chinese patients. This case-control study enrolled 605 patients (males, 337; females, 268) with T2D and 724 healthy subjects (males, 405; females, 319) at Sir Run Run Shaw Hospital from February to April 2014. Dietary calcium, total energy, fat to energy ratio, glucose administration, 2-h postprandial blood glucose, serum total cholesterol and high density lipoprotein (HDL)-cholesterol, and serum 25OHD level were assessed...
2017: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/29224579/wilder-penfield-sir-arthur-currie-and-the-montreal-neurological-institute
#11
R Mark Sadler
Wilder Penfield and the Montreal Neurological Institute (MNI) are inextricably linked. It was Penfield's unique idea to create a building with an academic atmosphere wherein basic neuroscience and clinical care of neurological patients would benefit from interaction and mutual support. It is clear that without Penfield that there would be no MNI; however, the role of another Canadian icon, Sir Arthur Currie, in the development of the MNI has heretofore been barely mentioned. The thesis of this paper is that Currie had a critical role in the gestation of the MNI that has generally been ignored...
December 11, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29221655/impact-of-interleukin-6-and-interleukin-10-serum-levels-and-mrna-expression-level-on-polytrauma-patients
#12
Heber B Sapan, Idrus Paturusi, Andi Asadul Islam, Irawan Yusuf, Ilhamjaya Patellongi, Muhammmad Nasrum Massi, Aryono D Pusponegoro, Syafrie K Arief, Ibrahim Labeda, Leo Rendy, Mochammad Hatta
INTRODUCTION: Host response to polytrauma occasionally has unpredictable outcomes. Immune response is a major factor influencing patient's outcome. This study evaluated the interaction of two main cytokines in immune response after major trauma, specifically interleukin-6 (IL-6) and interleukin-10 (IL-10) in which their serum level comes from the mRNA expression of these cytokine genes and outcome of polytrauma patients. METHODS: This prospective multicenter trial held at four trauma centers enrolled 54 polytrauma patients [Injury Severity Score (ISS) ≥ 16]...
November 4, 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/29221279/endoscopic-naso-leakage-drainage-a-safe-and-effective-method-for-the-management-of-intrathoracic-anastomotic-leakage-after-esophagectomy
#13
Yi Zhang, Yong-Xing Zhang, Jian-Wei Hu, Guang-Yu Yao, Liang Xue, Hong Fan, Yi-Qun Zhang, Qun Wang
Background: Intrathoracic anastomotic leakage (IAL) remains a major complication of esophagectomy. Main non-surgical options of management include chest drainage and endoscope interventions. This study is aim to present our experience and assess the efficacy of endoscopic naso-leakage drainage (ENLD) in patients with IAL. Methods: From June 2011 to January 2017, 67 patients who developed IAL after esophagectomy and managed by non-surgical approaches were analyzed retrospectively...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29218047/reverse-transcriptase-mechanism-of-somatic-hypermutation-60-years-of-clonal-selection-theory
#14
Edward J Steele
The evidence for the reverse transcriptase mechanism of somatic hypermutation is substantial and multifactorial. In this 60th anniversary year of the publication of Sir MacFarlane Burnet's Clonal Selection Theory, the evidence is briefly reviewed and updated.
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29217492/the-potential-role-of-ideal-mri-for-identification-of-lipids-and-hemorrhage-in-carotid-artery-plaques
#15
Faisal Khosa, Rachel E Clough, Xiaoen Wang, Ananth J Madhuranthakam, Robert L Greenman
Hemorrhage and lipid deposits contribute to instability in atherosclerotic plaques. Unstable carotid artery plaques can lead to cerebral ischemic events. While MRI studies have shown the ability to identify plaque components, the identification of hemorrhage and lipids has proven to be problematic. The purpose of this study was to quantitatively evaluate the potential of the MRI fat/water separation method known as iterative decomposition of water and fat with echo asymmetry and least squares estimation (IDEAL) to complement and improve existing methods for the identification of hemorrhage and lipids in carotid artery plaques...
December 4, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29215488/cancer-incidence-among-hardmetal-production-workers-the-swedish-cohort
#16
Magnus Svartengren, Ing-Liss Bryngelsson, Gary Marsh, Jeanine Buchanich, Sarah Zimmerman, Kathleen Kennedy, Nurtan Esmen, Håkan Westberg
: The cancer incidence was determined for 3713 workers from three plants from 1958 to 2011. The exposure measures were ever/never exposed, duration, cumulative, and mean cobalt concentrations.The incidence of all malignant neoplasms was increased at one plant, but standardized incidence ratio (SIR) was 0.96 for all workers. Lung cancer incidence was increased for all workers, SIR 1.38 (1.01 to 1.85). The lung cancer incidence was associated with shorter employment time and showed no exposure-response. There was decreased incidence for skin cancer...
December 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29215168/decreased-signal-intensity-ratio-on-mra-reflects-misery-perfusion-on-spect-in-patients-with-intracranial-stenosis
#17
Masatomo Miura, Makoto Nakajima, Akiko Fujimoto, Shinya Shiraishi, David S Liebeskind, Yukio Ando
BACKGROUND AND PURPOSE: Acetazolamide reactivity on 123 I-IMP SPECT is used to detect misery perfusion due to intracranial atherosclerosis. Noninvasive fractional flow assessed by signal intensity ratio (SIR) on time of flight-magnetic resonance angiography (TOF-MRA) might offer a feasible alternative to identify high-risk intracranial stenosis. METHODS: Data from consecutive patients with unilateral middle cerebral artery (MCA) stenosis who underwent both TOF-MRA and acetazolamide reactivity on 123 I-IMP SPECT were retrospectively analyzed...
December 7, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29210502/three-dimensional-static-articulation-accuracy-of-virtual-models-part-ii-effect-of-model-scanner-cad-systems-and-articulation-method
#18
Sophia Hui Xin Yee, Roxanna Jean Esguerra, Amelia Anya Qin'An Chew, Keng Mun Wong, Keson Beng Choon Tan
PURPOSE: Accurate maxillomandibular relationship transfer is important for CAD/CAM prostheses. This study compared the 3D-accuracy of virtual model static articulation in three laboratory scanner-CAD systems (Ceramill Map400 [AG], inEos X5 [SIR], Scanner S600 Arti [ZKN]) using two virtual articulation methods: mounted models (MO), interocclusal record (IR). MATERIALS AND METHODS: The master model simulated a single crown opposing a 3-unit fixed partial denture. Reference values were obtained by measuring interarch and interocclusal reference features with a coordinate measuring machine (CMM)...
December 6, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29207939/tocilizumab-for-the-management-of-immune-mediated-adverse-events-secondary-to-pd-1-blockade
#19
Chipman Rg Stroud, Aparna Hegde, Cynthia Cherry, Abdul R Naqash, Nitika Sharma, Srikala Addepalli, Sulochana Cherukuri, Teresa Parent, Jessica Hardin, Paul Walker
Background Immune checkpoint inhibitors are poised to revolutionize the management of a growing number of malignancies. Unfortunately, the management of steroid-refractory immune mediated adverse events is based on a paucity of randomized data and limited to single center experiences. Our initial experience with the IL-6 receptor antagonist tocilizumab showed clinical improvement in a wide variety of irAEs. As a result, we adopted the use of tocilizumab for the management of steroid refractory irAEs. Methods The character and clinical course of irAEs were abstracted from the medical record and analyzed...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29206312/risk-of-cancer-in-children-exposed-to-antiretroviral-nucleoside-analogues-in-utero-the-french-experience
#20
Mira Hleyhel, Stéphanie Goujon, Jeanne Sibiude, Roland Tubiana, Catherine Dollfus, Albert Faye, Laurent Mandelbrot, Jacqueline Clavel, Josiane Warszawski, Stéphane Blanche
All nucleoside analogues for treating HIV infection, due to their capacity to integrate into and alter human DNA, are experimentally genotoxic to some extent. The long-term oncogenic risk after in utero exposure remains to be determined. Cancer incidence in uninfected children exposed to nucleos(t)ide reverse transcriptase inhibitors (NRTIs) was evaluated, by cross-checking against the National Cancer Registry, in the French perinatal study of children born to HIV+ mothers. Twenty-one cancers were identified in 15,163 children (median age: 9...
December 5, 2017: Environmental and Molecular Mutagenesis
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