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https://www.readbyqxmd.com/read/28107070/tracheal-collapse-in-a-pekin-duck-anas-platyrhynchos-domestica
#1
Eugénie Henry-Guyot, Isabelle Langlois, Isabelle Lanthier, Dipl Acvp
A 5-year-old, 3.72-kg female Pekin duck ( Anas platyrhynchos domestica) was presented for acute respiratory distress, head shaking, and collapse. Similar spontaneously resolving episodes had previously occurred. Physical examination revealed severe inspiratory and expiratory dyspnea. Due to poor prognosis, euthanasia was elected. Postmortem examination revealed severe tracheal collapse involving the proximal trachea. The tracheal lumen was reduced in size by 75%. Histologic evaluation revealed ossification of the tracheal rings for approximately 60%-100% of their circumference...
December 2016: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/28105760/aerosol-based-airway-epithelial-cell-delivery-improves-airway-regeneration-and-repair
#2
E Kardia, E S Ch'ng, B H Yahaya
Aerosol-based cell therapy has emerged as a novel and promising therapeutic strategy for treating lung diseases. The goal of this study was to determine the safety and efficacy of aerosol-based airway epithelial cell (AEC) delivery in the setting of acute lung injury induced by tracheal brushing in rabbit. 24 hours following injury, exogenous rabbit AECs were labelled with BrdU and aerosolized using the MicroSprayer® Aerosolizer into the injured airway. Histopathological assessments of the injury in the trachea and lungs were quantitatively scored (1 and 5 d after cell delivery)...
January 20, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28100332/-expression-and-significance-of-mtor-4ebp1-hif-1%C3%AE-vegf-signaling-pathway-in-lung-tissues-of-asthmatic-mice
#3
Li Wang, Yan-Li Zhang, Xiu-Fang Wang, Zhe Song, Wei Wang
OBJECTIVE: To study the expression and significance of the mammalian target of rapamycin (mTOR)/eukaryote initiating factor 4E binding protein 1(4EBP1)/hypoxia inducible factor-1α (HIF-1α)/vascular endothelial growth factor (VEGF) signaling pathway in asthmatic mice. METHODS: Forty SPF level 6-8 week-old female Balb/C mice were randomly divided into control, asthma, budesonide and mTOR inhibitor (rapamycin) intervention groups (n=10 each). The asthmatic mouse model was prepared via OVA induction and challenge test...
January 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28099576/bpi-fold-bpif-containing-plunc-protein-expression-in-human-fetal-major-and-minor-salivary-glands
#4
Daniel Berretta Moreira Alves, Lynne Bingle, Colin David Bingle, Silvia Vanessa Lourenço, Andréia Aparecida Silva, Débora Lima Pereira, Pablo Agustin Vargas
The aim of this study was to determine expression, not previously described, of PLUNC (palate, lung, and nasal epithelium clone) (BPI-fold containing) proteins in major and minor salivary glands from very early fetal tissue to the end of the second trimester and thus gain further insight into the function of these proteins. Early fetal heads, and major and minor salivary glands were collected retrospectively and glands were classified according to morphodifferentiation stage. Expression of BPI-fold containing proteins was localized through immunohistochemistry...
January 16, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28097001/mag-dpa-curbs-inflammatory-biomarkers-and-pharmacological-reactivity-in-cytokine-triggered-hyperresponsive-airway-models
#5
Rayan Khaddaj-Mallat, Roddy Hiram, Chantal Sirois, Marco Sirois, Edmond Rizcallah, Sofia Marouan, Caroline Morin, Éric Rousseau
Bronchial inflammation contributes to a sustained elevation of airway hyperresponsiveness (AHR) in asthma. Conversely, omega-3 fatty acid derivatives have been shown to resolve inflammation in various tissues. Thus, the effects of docosapentaenoic acid monoacylglyceride (MAG-DPA) were assessed on inflammatory markers and reactivity of human distal bronchi as well as in a cultured model of guinea pig tracheal rings. Human bronchi were dissected and cultured for 48 h with 10 ng/mL TNF-α or IL-13. Guinea pig tracheas were maintained in organ culture for 72 h which was previously shown to trigger spontaneous AHR...
December 2016: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28095939/safe-balloon-sizing-for-endoscopic-dilatation-of-subglottic-stenosis-in-children
#6
S D Sharma, S L Gupta, M Wyatt, D Albert, B Hartley
OBJECTIVES: To describe our experience and provide guidelines for maximum safe balloon sizes according to age in children undergoing balloon dilatation. METHOD: A retrospective review was conducted of children undergoing balloon dilatation for subglottic stenosis in a paediatric tertiary unit between May 2006 and February 2016. RESULTS: A total of 166 patients underwent balloon dilatation. Mean ( ± standard deviation) patient age was 4.5 ± 3...
January 18, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28094453/down-regulation-of-a-chitin-synthase-a-gene-by-rna-interference-enhances-pathogenicity-of-beauveria-bassiana-anu1-against-spodoptera-exigua-h%C3%A3-bner
#7
Jung-Bok Lee, Hyun Soo Kim, Youngjin Park
Chitin synthase (CHS) is an important enzymatic component, which is required for chitin formation in the cuticles and cuticular linings of other tissues in insects. CHSs have been divided into two classes, classes A and B, based on their amino acid sequence similarities and functions. Class A CHS (CHS-A) is specifically expressed in the epidermis and related ectodermal cells such as tracheal cells, while class B CHS (CHS-B) is expressed in gut epithelial cells that produce peritrophic matrices. In this study, we cloned the CHS-A gene from the beet armyworm, Spodoptera exigua (SeCHS-A)...
January 17, 2017: Archives of Insect Biochemistry and Physiology
https://www.readbyqxmd.com/read/28093727/gene-expression-boundary-scaling-and-organ-size-regulation-in-the-drosophila-embryo
#8
REVIEW
Christopher Amourda, Timothy E Saunders
How the shape and size of tissues and organs is regulated during development is a major question in developmental biology. Such regulation relies upon both intrinsic cues (such as signaling networks) and extrinsic inputs (such as from neighboring tissues). Here, we focus on pattern formation and organ development during Drosophila embryogenesis. In particular, we outline the importance of both biochemical and mechanical tissue-tissue interactions in size regulation. We describe how the Drosophila embryo can potentially provide novel insights into how shape and size are regulated during development...
January 16, 2017: Development, Growth & Differentiation
https://www.readbyqxmd.com/read/28088233/successful-recovery-from-a-subclavicular-ulcer-caused-by-lenvatinib-for-thyroid-cancer-a-case-report
#9
Morimasa Kitamura, Tomomasa Hayashi, Chiaki Suzuki, Shigeru Hirano, Ichiro Tateya, Yo Kishimoto, Koichi Omori
BACKGROUND: There are currently no effective therapeutic methods for locally recurrent, metastatic, or progressive radioactive iodine (RAI)-refractory differentiated thyroid cancer. However, multitargeted tyrosine kinase inhibitors (TKIs) such as lenvatinib or sorafenib have been approved for patients with RAI-refractory differentiated thyroid cancer as a second targeted therapy, and these agents can prolong patient survival. However, several cases have been reported that TKIs have caused fatal complications such as fistula formation or bleeding...
January 14, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28074723/-a-woman-with-excessive-dynamic-airway-collapse
#10
R L T N Salden, S Postma
BACKGROUND: 'Excessive dynamic airway collapse' (EDAC) is a form of tracheamalacia, that does not affect the rings of cartilage on the anterior side of the trachea, but in which the posterior wall of the trachea collapses during inspiration and expiration. CASE DESCRIPTION: An 80 year-old woman presented to the accident and emergency department with dyspnoea and severe inspiratory and expiratory stridor, with sudden onset a few hours previously. Following a series of investigations, she was shown to have a narrowing of the trachea, radiating from the posterior wall...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28074497/in-vivo-imaging-of-the-progression-of-acute-lung-injury-using-hyperpolarized-1-13-c-pyruvate
#11
Mehrdad Pourfathi, Yi Xin, Stephen J Kadlecek, Maurizio F Cereda, Harrilla Profka, Hooman Hamedani, Sarmad M Siddiqui, Kai Ruppert, Nicholas A Drachman, Jennia N Rajaei, Rahim R Rizi
PURPOSE: To investigate pulmonary metabolic alterations during progression of acute lung injury. METHODS: Using hyperpolarized [1-(13) C] pyruvate imaging, we measured pulmonary lactate and pyruvate in 15 ventilated rats 1, 2, and 4 h after initiation of mechanical ventilation. Lung compliance was used as a marker for injury progression. 5 untreated rats were used as controls; 5 rats (injured-1) received 1 ml/kg and another 5 rats (injured-2) received 2 ml/kg hydrochloric acid (pH 1...
January 11, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28072944/the-three-dimensional-3d-printing-of-a-flexible-trachea
#12
J Y Young, I C Chao, J C Coles-Black
No abstract text is available yet for this article.
January 2017: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/28070690/reconstruction-of-defects-of-the-trachea
#13
Margot Den Hondt, Jan Jeroen Vranckx
The trachea has a complex anatomy to fulfill its tasks. Its unique fibro-cartilaginous structure maintains an open conduit during respiration, and provides vertical elasticity for deglutition, mobility of the neck and speech. Blood vessels pierce the intercartilaginous ligaments to perfuse the ciliated epithelium, which ensures effective mucociliary clearance. Removal of a tracheal segment affected by benign or malignant disease requires airtight restoration of the continuity of the tube. When direct approximation of both tracheal ends is no longer feasible, a reconstruction is needed...
February 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28066625/the-anesthesia-of-trachea-and-bronchus-surgery
#14
REVIEW
Zehra Hatipoglu, Mediha Turktan, Alper Avci
The trachea and bronchus surgery is generally performed due to stenosis, traumatic injury, foreign body and tumors. Preoperative evaluation and anesthesia management are very important issues because of higher mortality and morbidity rates. Patients may be asymptomatic, but airway difficulties, hypoxia, stridor, cough, hemoptysis are common conditions in these patient population. The collaboration between the surgeon and the anesthesiologist is very substantial and necessary. Anesthetic techniques include various applications such as one lung ventilation, fiberoptic intubation, jet ventilation, and apneic oxygenation, general anesthesia with or without neuromuscular blockade...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28066620/tracheobronchial-tumors
#15
REVIEW
Ruza Stevic, Branislava Milenkovic
Tumors of trachea and bronchi are uncommon and can occur in the form of benign or low- and high-grade malignant tumors. Although tracheobronchial tumors (TBTs) represent only 0.6% of all pulmonary tumors, they are clinically significant. Delays in diagnosis of these tumors commonly occur because the signs and symptoms caused by these tumors are nonspecific and chest radiographs are often considered unremarkable. Therefore, novel radiological techniques and better access to flexible bronchoscopy enable detection of larger number of TBT...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28066613/tracheal-suspension-by-using-3-dimensional-printed-personalized-scaffold-in-a-patient-with-tracheomalacia
#16
Lijun Huang, Lei Wang, Jiankang He, Jinbo Zhao, Daixing Zhong, Guanying Yang, Ting Guo, Xiaolong Yan, Lixiang Zhang, Dichen Li, Tiesheng Cao, Xiaofei Li
The major methods are used to fix or stabilize the central airways and major bronchi with either anterior suspension and/or posterior fixation for severe tracheomalacia (TM). Many support biomaterials, like mesh and sternal plate, can be used in the surgery. But there are no specialized biomaterials for TM which must be casually fabricated by the doctors in operation. Three dimensional printing (3DP) has currently untapped potential to provide custom, protean devices for challenging and life-threatening disease processes...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28062487/alcohol-drives-s-nitrosylation-and-redox-activation-of-protein-phosphatase-1-causing-bovine-airway-cilia-dysfunction
#17
Michael Earl Price, Jacqueline A Pavlik, Miao Liu, Shi-Jian Ding, Todd A Wyatt, Joseph H Sisson
Individuals with alcohol (ethanol) use disorders are at increased risk for lung infections in part due to defective mucociliary clearance driven by motile cilia in the airways. We recently reported that isolated demembranated bovine cilia (axonemes) are capable of producing nitric oxide (∙NO) when exposed to biologically relevant concentrations of alcohol. This increased presence of ∙NO can lead to protein S-nitrosylation, a posttranslational modification signaling mechanism involving reversible adduction of nitrosium cations or ⋅NO to thiolate or thiyl groups, respectively, of proteins forming S-nitrosothiols...
January 6, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28062130/-municipal-distribution-of-the-incidence-of-the-most-common-tumours-in-an-area-with-high-cancer-mortality
#18
Manuel Jesús Viñas Casasola, Pablo Fernández Navarro, María Luisa Fajardo Rivas, José Luis Gurucelain Raposo, Juan Alguacil Ojeda
OBJECTIVE: To describe the geographic distribution patterns of the municipal incidence of the most common tumours in the Huelva province (Spain) as compared to the estimated incidence for all of Spain. METHODS: Relative risk (RR) was computed based on the conditional autoregressive model proposed by Besag, York and Mollié by applying the INLA tool to the cancer data for 2007-2011 for the following tumour locations: colon, rectum and anus (men and women); trachea, bronchia, and lungs, prostate and bladder in men; and breasts in women...
January 3, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28058141/ultrasonographic-measurement-of-subglottic-diameter-for-paediatric-cuffed-endotracheal-tube-size-selection-feasibility-report
#19
Demet Altun, Mukadder Orhan Sungur, Achmet Ali, Emre Sertaç Bingül, Tülay Özkan Seyhan, Emre Çamcı
OBJECTIVE: The aim of this feasibility study was to investigate the first attempt success of ultrasonography (USG) in paediatric patients in predicting an appropriate cuffed endotracheal tube (ETT) size. METHODS: Fifty children who were 1-10 years of age and who received general anaesthesia with endotracheal intubation for adenoidectomy or adenotonsillectomy were enrolled in the study. In all participants, the transverse diameter of the subglottic airway was measured with USG at the cricoid level without ventilation...
December 2016: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/28052555/computational-modeling-of-tracheal-angioedema-due-to-swelling-of-the-submucous-tissue-layer
#20
Kun Gou, Thomas J Pence
Angioedema is a tissue swelling pathology due to rapid change in soft tissue fluid content. Its occurrence in the trachea is predominantly localized to the soft mucous tissue that forms the innermost tracheal layer. The biomechanical consequences, such as airway constriction, are dependent upon the ensuing mechanical interactions between all of the various tissues that comprise the tracheal tube. We model the stress interactions by treating the trachea organ as a three-tissue system consisting of swellable mucous in conjunction with nonswelling cartilage and nonswelling trachealis musculature...
January 4, 2017: International Journal for Numerical Methods in Biomedical Engineering
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