Benjamin Koch, Mahmoud Shehata, Christin Müller-Ruttloff, Shady A Gouda, Nils Wetzstein, Sammy Patyna, Anica Scholz, Tobias Schmid, Ursula Dietrich, Christian Münch, John Ziebuhr, Helmut Geiger, Luis Martinez-Sobrido, Patrick C Baer, Ahmed Mostafa, Stephan Pleschka
INTRODUCTION: Influenza A virus (IAV) infection can cause the often-lethal acute respiratory distress syndrome (ARDS) of the lung. Concomitantly, acute kidney injury (AKI) is frequently noticed during IAV infection, correlating with an increased mortality. The aim of this study was to elucidate the interaction of IAV with human kidney cells and, thereby, to assess the mechanisms underlying IAV-mediated AKI. METHODS: To investigate IAV effects on nephron cells we performed infectivity assays with human IAV, as well as with human isolates of either low or highly pathogenic avian IAV...
2024: Frontiers in Cellular and Infection Microbiology