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https://www.readbyqxmd.com/read/27903737/allergen-induced-cd4-t-cell-cytokine-production-within-airway-mucosal-dendritic-cell-t-cell-clusters-drives-the-local-recruitment-of-myeloid-effector-cells
#1
Tibor Z Veres, Tamás Kopcsányi, Nicholas van Panhuys, Michael Y Gerner, Zhiduo Liu, Pia Rantakari, Johannes Dunkel, Masayuki Miyasaka, Marko Salmi, Sirpa Jalkanen, Ronald N Germain
Allergic asthma develops in the mucosal tissue of small bronchi. At these sites, local cytokine production by Th2/Th17 cells is believed to be critical for the development of tissue eosinophilia/neutrophilia. Using the mouse trachea as a relevant model of human small airways, we performed advanced in vivo dynamic and in situ static imaging to visualize individual cytokine-producing T cells in the airway mucosa and to define their immediate cellular environment. Upon allergen sensitization, newly recruited CD4(+) T cells formed discrete Ag-driven clusters with dendritic cells (DCs)...
November 30, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27902901/virulence-of-serovar-c-1-strains-of-avibacterium-paragallinarum
#2
H H Trujillo-Ruíz, H L Shivaprasad, V Morales-Erasto, M Talavera-Rojas, C Salgado-Miranda, F Salazar-García, P J Blackall, E Soriano-Vargas
The bacterium Avibacterium paragallinarum is the etiologic agent of infectious coryza of chickens. There are nine serovars of A. paragallinarum , and serovar C-1 has emerged in outbreaks of infectious coryza in layer hens in the Americas, with all isolates having been obtained from infectious coryza-vaccinated chickens. In the current study, the clinical and histopathologic outcomes of experimental infections in chickens with A. paragallinarum of serovar C-1 were investigated. The Japanese serovar reference strain, H-18, and a Mexican isolate, ESV-135, were included in the study...
December 2016: Avian Diseases
https://www.readbyqxmd.com/read/27902641/diaphragmatic-and-intercostal-electromyographic-activity-during-neostigmine-sugammadex-and-neostigmine-sugammadex-enhanced-recovery-after-neuromuscular-blockade-a-randomised-controlled-volunteer-study
#3
Guy Cammu, Tom Schepens, Nikolaas De Neve, Davina Wildemeersch, Luc Foubert, Philippe G Jorens
BACKGROUND: Electromyographic activity of the diaphragm (EMGdi) during weaning from mechanical ventilation is increased after sugammadex compared with neostigmine. OBJECTIVE: To determine the effect of neostigmine on EMGdi and surface EMG (sEMG) of the intercostal muscles during antagonism of rocuronium block with neostigmine, sugammadex and neostigmine followed by sugammadex. DESIGN: Randomised, controlled, double-blind study. SETTING: Intensive care research unit...
January 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/27900328/blunt-traumatic-tension-chylothorax-case-report-and-mini-review-of-the-literature
#4
Kamal Idris, Michael Sebastian, Ashraf F Hefny, Navidul Haq Khan, Fikri M Abu-Zidan
Tension chylothorax following blunt thoracic trauma is an extremely rare condition. Here we report such a case and review its management. A 31-year-old man was involved in a road traffic collision. The car rolled over and the patient was ejected from the vehicle. On arrival at the Emergency Department the patient was conscious and haemodynamically stable. Clinical examination of the chest and abdomen was normal. The patient had sustained fractures of the sixth cervical vertebra and the tenth thoracic vertebra, left pleural effusion, haematoma around the descending aorta and fracture of the right clavicle...
November 16, 2016: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/27896158/congenital-duodenal-obstruction-in-neonates-over-13-years-experience-from-a-single-centre
#5
Parveen Kumar, Chiranjiv Kumar, Prince Raj Pandey, Yogesh Kumar Sarin
AIM: To study the prevalence of associated anomalies with neonatal duodenal obstruction and factors impacting short-term survival. MATERIAL AND METHODS: Records of 31 neonates with neonatal duodenal obstruction could be retrieved and analyzed for a 13.5-year-period (October 2003-May 2016). M:F ratio was 1.58:1. The mean birth weight was 2.15 kg; 12 patients were preterm. Etiologies included duodenal atresia (n=23), duodenal web (n=8) and malrotation of gut (n= 6)...
October 2016: Journal of Neonatal Surgery
https://www.readbyqxmd.com/read/27896063/necrotizing-tracheobronchitis-associated-with-rheumatoid-arthritis
#6
Shigehisa Kajikawa, Kazushi Noda, Yasuhiro Nozaki
We report a case of necrotizing tracheobronchitis with rheumatoid arthritis. A 64 year-old-man presented with dry cough and was initially diagnosed with community-acquired pneumonia. The patient was admitted; he received initial antibiotic treatment. The treatment was effective and the symptoms worsened. Bronchoscopy was performed for more thorough examination. It showed that white and soft tissues were on the trachea-bronchus. Transbronchial biopsy of the tracheal lesions revealed necrotic tissue with squamous metaplasia and inflammatory cells...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/27894962/clinico-pathology-and-hemato-biochemistry-responses-in-buffaloes-infected-with-pasteurella-multocida-type-b-2-immunogen-outer-membrane-protein
#7
Eric Lim Teik Chung, Faez Firdaus Jesse Abdullah, Ali Dhiaa Marza, Wessam Monther Mohammed Saleh, Hayder Hamzah Ibrahim, Yusuf Abba, Mohd Zamri-Saad, Abd Wahid Haron, Abdul Aziz Saharee, Mohd Azmi Mohd Lila, Mohd Jefri Norsidin
The aim of this study was to investigate the clinico-pathology and haemato-biochemistry alterations in buffaloes inoculated with Pasteurella multocida type B:2 immunogen outer membrane protein via subcutaneous and oral routes. Nine buffalo heifers were divided equally into 3 treatment groups. Group 1 was inoculated orally with 10 mL of phosphate buffer saline (PBS); Group 2 and 3 were inoculated with 10 mL of outer membrane protein broth subcutaneously and orally respectively. Group 2 buffaloes showed typical haemorrhagic septicaemia clinical signs and were only able to survive for 72 h of the experiment...
November 25, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27890997/complete-subglottic-tracheal-stenosis-managed-with-rigid-bronchoscopy-and-t-tube-placement
#8
Kuruswamy Thurai Prasad, Sahajal Dhooria, Inderpaul Singh Sehgal, Ashutosh Nath Aggarwal, Ritesh Agarwal
Surgery is the preferred treatment modality for benign tracheal stenosis. Interventional bronchoscopy is used as a bridge to surgery or in instances when surgery is not feasible or has failed. Stenosis in the subglottic trachea is particularly a treatment challenge, in view of its proximity to the vocal cords. Herein, we describe a patient with complete tracheal stenosis in the subglottic region, which developed after prolonged intubation and mechanical ventilation. The patient developed recurrent stenosis despite multiple surgical and endoscopic procedures...
November 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27888824/clinico-radiological-parameters-predicting-early-diagnosis-of-foreign-body-aspiration-in-children
#9
Pradipta Kumar Parida, Nirmal Shanmugasundaram, Surianarayanan Gopalakrishnan
OBJECTIVES: This study aims to investigate clinical and radiological findings to make early diagnosis of foreign body (FB) aspiration in children. PATIENTS AND METHODS: This prospective study was conducted on 45 children younger than 12 years with a clinical diagnosis of FB aspiration undergone rigid bronchoscopy between September 2010 and May 2014. The results of 37 children (22 males, 15 females; mean age 2.6 years; range 1 to 12 years) with positive for FB on bronchoscopy were analyzed...
September 2016: Kulak Burun Boğaz Ihtisas Dergisi: KBB, Journal of Ear, Nose, and Throat
https://www.readbyqxmd.com/read/27887682/tracheal-cartilage-growth-by-intratracheal-injection-of-basic-fibroblast-growth-factor
#10
Makoto Komura, Hiroko Komura, Hiroaki Komuro, Kenichi Ikebukuro, Atsuhiko Hikita, Kazuto Hoshi, Tsuyoshi Takato
BACKGROUND/PURPOSE: We have previously shown that intratracheal injection of slowly released (in gelatin) basic fibroblast growth factor (bFGF) significantly enlarged the tracheal lumen by a slight margin. This study aimed to investigate differences in tracheal cartilage growth by the intratracheal injection of bFGF doses in a rabbit model. METHODS: Water (group 1; n=7; control) or 100μg (group 2; n=8) or 200μg (group 3; n=8) of bFGF dissolved in water was injected into the posterior wall of the cervical trachea of New Zealand white rabbits using a tracheoscope...
November 13, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27886803/relapsing-polychondritis-a-2016-update-on-clinical-features-diagnostic-tools-treatment-and-biological-drug-use
#11
REVIEW
Alexis Mathian, Makoto Miyara, Fleur Cohen-Aubart, Julien Haroche, Miguel Hie, Micheline Pha, Philippe Grenier, Zahir Amoura
Relapsing polychondritis (RP) is a very rare autoimmune disease characterised by a relapsing inflammation of the cartilaginous tissues (joints, ears, nose, intervertebral discs, larynx, trachea and cartilaginous bronchi), which may progress to long-lasting atrophy and/or deformity of the cartilages. Non-cartilaginous tissues may also be affected, such as the eyes, heart, aorta, inner ear and skin. RP has a long and unpredictable course. Because no randomised therapeutic trials are available, the treatment of RP remains mainly empirical...
April 2016: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/27885873/effects-of-artificial-tracheal-fixation-on-tracheal-epithelial-regeneration-and-prevention-of-tracheal-stenosis
#12
Yuta Nakaegawa, Ryosuke Nakamura, Yasuhiro Tada, Ryo Suzuki, Toshiaki Takezawa, Tatsuo Nakamura, Koichi Omori
CONCLUSION: Tight fixation of the artificial trachea is important for epithelialization and tracheal stenosis. OBJECTIVE: The authors have developed an artificial trachea and have used it for tracheal reconstruction. Although various studies on tracheal reconstruction have been conducted, no studies have examined the effect of artificial tracheal fixation on tracheal stenosis and regeneration. Therefore, the purpose of the present study was to evaluate the effect of artificial tracheal fixation...
November 25, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27882259/right-lung-agenesis-with-tracheal-stenosis-due-to-complete-tracheal-rings-and-postpneumonectomy-like-syndrome-treated-with-tissue-expander-placement
#13
Yashwant Agrawal, Sandeep Patri, Jagadeesh K Kalavakunta
Congenital lung agenesis is an extremely rare condition with an estimated prevalence of 34 in 1,000,000 live births. It is often associated with other congenital malformations of the skeletal, cardiovascular, urogenital, and gastrointestinal systems. We discuss the case of a 5-month-old who presented with increasing stridor over 1 month. Imaging revealed right lung agenesis, complete dextromalposition of heart, and compression of distal trachea. An intrathoracic saline tissue expander was placed which marked improved distal tracheal stenosis...
2016: Case Reports in Pulmonology
https://www.readbyqxmd.com/read/27882028/patient-specific-depth-of-endotracheal-intubation-from-anthropometry-to-the-touch-and-read-method
#14
Saecheol Oh, Seunguk Bang, Woojin Kwon, Jungwoo Shim
OBJECTIVE: Knowledge of accurate airway length (AL) enables safer placement of the endotracheal tube (ETT) in the trachea. Our objective was to check the safety of a new formula (Touch and Read method) to determine ETT depth. METHODS: AL was measured in 176 patients. Patients were divided into a normal group (AL >25 cm in men, >23 cm in women) and a risk group (AL ≤25 cm in men, ≤23cm in women). A control test (Conventional method) was performed in which the ETT was secured at a depth of 23 cm from the central incisor in men and 21 cm in women...
September 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27877233/the-impact-of-clinical-stage-on-radiation-doses-to-organs-at-risk-following-intensity-modulated-radiotherapy-in-nasopharyngeal-carcinoma-a-prospective-analysis
#15
Lin Xu, Ji-Jin Yao, Guan-Qun Zhou, Wang-Jian Zhang, Guo-Long Liu, Li-Zhi Liu, Jun Ma, Ying Sun
Background: The development of intensity-modulated radiotherapy (IMRT) has revolutionized the management of nasopharyngeal carcinoma (NPC). The purpose of this study was to investigate the impact of clinical stage on radiation doses to organs at risk (OARs) in NPC. Material and Methods: One hundred and forty-eight patients with newly diagnosed and untreated NPC were prospectively enrolled. Based on the anatomic definition and pathogenesis of radiation induced injury, a total of 28 OARs surrounding the nasopharynx were contoured on axial computed tomography (CT) planning images in each patient...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27877084/rna-interference-of-chitin-synthase-genes-inhibits-chitin-biosynthesis-and-affects-larval-performance-in-leptinotarsa-decemlineata-say
#16
Ji-Feng Shi, Li-Li Mu, Xu Chen, Wen-Chao Guo, Guo-Qing Li
Dietary introduction of bacterially expressed double-stranded RNA (dsRNA) has great potential for management of Leptinotarsa decemlineata. Identification of the most attractive candidate genes for RNA interference (RNAi) is the first step. In the present paper, three complete chitin synthase cDNA sequences (LdChSAa, LdChSAb and LdChSB) were cloned. LdChSAa and LdChSAb, two splicing variants of LdChSA gene, were highly expressed in ectodermally-derived epidermal cells forming epidermis, trachea, foregut and hindgut, whereas LdChSB was mainly transcribed in midgut cells...
2016: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/27876747/-a-large-foreign-body-a-pin-in-the-trachea
#17
D M Mustafaev
A foreign body is known to be retained in the human trachea only in very rare cases, e.g. due to its large size preventing the further passage through the glottis into a bronchial tube or because of its specific shape facilitating the attachment of the body to the tracheal walls and clamping between them. In this paper, the author presents a case of the localization of an unusually large foreign body (a pin) in the trachea of a 14 year old child.
2016: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/27876259/a-diagnostic-dilemma-for-the-pediatrician-radiolucent-tracheobronchial-foreign-body
#18
Hakan Taşkınlar, Gökhan Berktuğ Bahadır, Cankat Erdoğan, Doğakan Yiğit, Dinçer Avlan, Ali Naycı
BACKGROUND: The purpose of this study is to determine the role of clinical history, physical examinations, and radiological findings in the evaluation of patients with suspected radiolucent foreign body aspiration. METHODS: The medical records of 236 children (under the age of 18 years), on whom a rigid bronchoscopy was performed between 1999 and 2015 because of suspected radiolucent foreign body aspiration, were analyzed retrospectively. Sensitivity, specificity, positive and negative predictive values of clinical history, physical examinations, and radiological findings were evaluated...
October 28, 2016: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/27873528/transplantation-of-vascularized-composite-allografts-review-of-current-knowledge
#19
M Molitor
Transplantation in reconstructive surgery has been performed for more than 20 years, although the official beginning of these procedures is considered the first successful transplantation of the hand in 1998. The original name "Composite Tissue Transplantation" has been used less frequently; more common is the term "Vascularized Composite Allotransplant", which better describes the basis of the procedure. There have been so far approximately 180 transplantations performed, the exact number is difficult to find...
2016: Acta Chirurgiae Plasticae
https://www.readbyqxmd.com/read/27873304/stent-induced-tracheal-stenosis-can-be-predicted-by-il-8-expression-in-rabbits
#20
Elena Arellano-Orden, Carolina Serrano, Ana Montes-Worboys, Verónica Sánchez-López, Alicia Laborda, Fernando Lostalé, Celia Lahuerta, Francisco Rodríguez-Panadero, Miguel Ángel de Gregorio
BACKGROUND: Bare metal stents may cause complications like fibrous encapsulation, granulation and tracheal stenosis. We investigated the behavior of three commercially available stents in vivo (rabbits) and in vitro (co-culture of those stents with epithelial and fibroblast cell lines). Also, we investigated whether development of tracheal stenosis could be predicted by any biological marker. METHODS: The tracheae of 30 rabbits were implanted with either nitinol stents, with or without paclitaxel elution, or a cobalt-based stent...
November 22, 2016: European Journal of Clinical Investigation
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