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https://www.readbyqxmd.com/read/28453906/oral-treponeme-major-surface-protein-sequence-diversity-and-distributions-within-periodontal-niches
#1
Meng You, Yuki Chan, Donnabella C Lacap-Bugler, Yong-Biao Huo, Wenling Gao, W Keung Leung, Rory M Watt
Treponema denticola and other species (phylotypes) of oral spirochetes are widely-considered to play important etiological roles in periodontitis and other oral infections. The major surface protein (Msp) of T. denticola is directly implicated in several pathological mechanisms. Here, we have analyzed msp sequence diversity across 68 strains of oral phylogroup 1 and 2 treponemes; including reference strains of T. denticola, Treponema putidum, Treponema medium, 'Treponema vincentii', and 'Treponema sinensis'...
April 28, 2017: Molecular Oral Microbiology
https://www.readbyqxmd.com/read/28446129/novel-predictors-of-neurosyphilis-among-hiv-negative-syphilis-patients-with-neurological-symptoms-an-observational-study
#2
Yao Xiao, Man-Li Tong, Li-Li Liu, Li-Rong Lin, Mei-Jun Chen, Hui-Lin Zhang, Wei-Hong Zheng, Shu-Lian Li, Hui-Ling Lin, Zhi-Feng Lin, Hui-Qin Xing, Jian-Jun Niu, Tian-Ci Yang
BACKGROUND: Known predictors of neurosyphilis were mainly drawn from human immunodeficiency virus (HIV)-infected syphilis patients, which may not be applicable to HIV-negative populations as they have different characteristics, particularly those with neurological symptoms. This study aimed to identify novel predictors of HIV-negative symptomatic neurosyphilis (S-NS). METHODS: From June 2005 to June 2015, 370 HIV-negative syphilis patients with neurological symptoms were recruited, consisting of 191 S-NS patients (including 123 confirmed neurosyphilis and 68 probable neurosyphilis patients) and 179 syphilis/non-neurosyphilis (N-NS) patients...
April 26, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28440740/biomarkers-and-bacteria-around-implants-and-natural-teeth-in-the-same-individuals
#3
Önder Gürlek, Pınar Gümüş, Christopher J Nile, David F Lappin, Nurcan Buduneli
AIM: This cross-sectional study assessed cytokine levels in peri-implant crevicular fluid (PICF)/ gingival crevicular fluid (GCF) and a selection of subgingival/submucosal plaque bacteria from clinically healthy or diseased sites in the same individuals. MATERIAL AND METHODS: Samples from 97 implants/teeth (58 implants: 19 healthy, 20 mucositis, 19 peri-implantitis; 39 natural teeth: 19 healthy, 12 gingivitis, 8 periodontitis) in 15 systemically healthy patients were investigated by immunoassay, real-time PCR...
April 25, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28435379/shifts-of-subgingival-bacterial-population-after-nonsurgical-and-pharmacological-therapy-of-localized-aggressive-periodontitis-followed-for-1-year-by-ion-torrent-pgm-platform
#4
Giuseppina Campisciano, Annamaria Toschetti, Manola Comar, Rosanna Di Taranto, Federico Berton, Claudio Stacchi
The possibility of targeting the hypervariable region V3 of the 16S rRNA gene using Ion Torrent Personal Genome Machine (PGM) could provide a complete analysis of subgingival plaque samples, potentially able to identify microbiological species missed by culture-based methods. A 16-year-old female smoker patient, affected by localized aggressive periodontitis, underwent a full-mouth disinfection protocol and was inserted in a 3-month recall program. Microbiological samples were collected at baseline and at 30, 100, 365 days follow-up and analyzed by Ion Torrent PGM...
January 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/28432950/effects-of-chlortetracycline-and-copper-on-tetracyclines-and-copper-resistance-genes-and-microbial-community-during-swine-manure-anaerobic-digestion
#5
Rui Wang, Meixue Chen, Feng Feng, Junya Zhang, Qianwen Sui, Juan Tong, Yuansong Wei, Dongbin Wei
As antibiotic and heavy metals are over used in the livestock industry, animal manure is a reservoir of antibiotic resistance genes (ARGs). Anaerobic digestion has been reported to have the potential to reduce ARGs. However, few studies investigated whether reduction of ARGs would be affected by different external pressures including antibiotics and heavy metals during anaerobic digestion. The purpose of this study was thus to investigate effects of both chlortetracycline (CTC) and Cu on reduction of ARGs, heavy metal resistance genes (HMRGs) and mobile genetic elements (MGEs) during the swine manure anaerobic digestion...
March 25, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28428838/a-national-strategic-plan-for-reducing-the-burden-of-sexually-transmitted-infections-in-israel-by-the-year-2025
#6
Daniel Chemtob, Dan Gandacu, Zohar Mor, Itamar Grotto, Emilia Anis, Elliot Rosenberg
BACKGROUND: There is on ongoing debate in the literature regarding the real burden of STIs (sexually transmitted infections) in Western countries and the proper strategies needed to estimate and to prevent them. Our purpose is to present an evidence-based national strategic plan for STI prevention in Israel through assessing the current burden of illness, leading international preventive strategies, and practical policymaking experience. METHODS: Epidemiologic and health policy data on STIs were analyzed from various sources: a) systematic national surveillance data for the years 2002-2014; b) the international scientific literature (published between 2002-16; keywords: Sexually Transmitted Diseases (STD) (or STI) AND prevention AND intervention AND gonorrhea OR chlamydia OR syphilis; c) internal Ministry of Health (MOH) analyses and reports, and d) expert opinion...
2017: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/28414665/a-case-of-early-neurosyphilis
#7
M Walker, R Wisler, J Simmons, A Johnson
INTRODUCTION: Neurosyphilis is an infection of the central nervous system by Treponema pallidum, which can occur after the initial syphilis infection. Although commonly associated with late stage disease, patients with early neurosyphilis may present with acute syphilitic meningitis, meningovascular syphilis, or uveitis. CASE: A 28 year old man with a past medical history of HIV (CD4 364);, and recent diagnosis of uveitis presented to the Emergency Department with a positive RPR result...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28410389/molecular-subtyping-of-treponema-pallidum-and-associated-factors-of-serofast-status-in-early-syphilis-patients-identified-novel-genotype-and-cytokine-marker
#8
Rui-Li Zhang, Qian-Qiu Wang, Jin-Ping Zhang, Li-Jia Yang
Serofast, a persistent nontreponemal serological response observed in early syphilis patients after conventional treatment, remains a concern of clinicians and syphilis patients. No consensus has been established, however, that defines an effective treatment strategy and clarifies the pathogenesis. In this study, 517 patients with early syphilis were enrolled and treated. Twelve months after treatment, 79.3% (410/517) of patients achieved serological cure, 20.1% (104/517) were serofast, and 0.6% (3/517) were serological failures...
2017: PloS One
https://www.readbyqxmd.com/read/28400821/the-great-impostor-transaminitis-masking-the-coinfection-of-syphilis-and-human-immunodeficiency-virus
#9
Sunit Tolia, Hassan Kassem, Ana Capatina-Rata
Introduction. The incidence of syphilis continues to rise in the United States over the past 15 years. This disease process is classified into stages and may present with a coinfection of Human Immunodeficiency Virus (HIV). Case Report. We present a case of a 32-year-old African American male who presented with cutaneous manifestations of secondary syphilis and transaminitis. A workup revealed that the transaminitis was secondary to underlying syphilitic hepatitis in the presence of HIV coinfection. The patient had a reactive rapid plasma reagin (RPR) of 1 : 64 TU and reactive Treponema pallidum particle agglutination assay (TPPA)...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28399709/treponema-pallidum-ssp-pallidum-identification-by-real-time-pcr-targetting-the-pola-gene-in-paraffin-embedded-samples-positive-by-immunohistochemistry
#10
A Gama, E M Carrillo-Casas, R Hernández-Castro, V A Vázquez-Aceituno, S Toussaint-Caire, J Xicohtencatl-Cortes, R Fernández-Martínez, G Moreno-Coutiño
Syphilis is a systemic and sexually transmitted infection caused by Treponema pallidum ssp. pallidum. This spirochete causes different clinical and subclinical stages depending on the duration of infection and immune status of the host. Several tests have been developed for diagnosis, and are classified into direct and indirect methods. The first one includes dark field microscopy, direct fluorescent antibody test in fluids or tissue, and molecular biology techniques. In the indirect method (serologic), the routine tests are used, and are divided in two categories: non-treponemal and treponemal ones...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28398683/update-on-syphilis-and-pregnancy
#11
REVIEW
Michael E Tsimis, Jeanne S Sheffield
While the origins of syphilis remain unknown, it has long been recognized as an infectious entity with complex pathophysiology. In this review, we highlighted the epidemiology and risk factors associated with syphilis. The incidence of syphilis in most populations showed a consistent upward trend until the 1940s with the introduction of penicillin as the preferred treatment. The emergence of congenital syphilis and vertical transmission has been a direct result of heterosexual syphilis transmission. We also explore the microbiology and pathogenesis of Treponema pallidum as it directly correlates with its route of transmission and infectivity...
March 15, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/28386552/l-glutamine-supplementation-alleviates-constipation-during-late-gestation-of-mini-sows-by-modifying-the-microbiota-composition-in-feces
#12
Yuanyuan Zhang, Taofeng Lu, Lingxia Han, Lili Zhao, Yinjie Niu, Hongyan Chen
Constipation occurs frequently in both sows and humans, particularly, during late gestation. The microbial community of the porcine gut, the enteric microbiota, plays a critical role in functions that sustain intestinal health. Hence, microbial regulation during pregnancy may be important to prevent host constipation. The present study was conducted to determine whether L-glutamine (Gln) supplementation improved intestinal function and alleviated constipation by regulation of enteric microbiota. 16S rRNA sequences obtained from fecal samples from 9 constipated sows (3 in the constipation group and 6 in the 1...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28381602/cerebrospinal-fluid-treponema-pallidum-particle-agglutination-assay-for-neurosyphilis-diagnosis
#13
Christina M Marra, Clare L Maxwell, Shelia B Dunaway, Sharon K Sahi, Lauren C Tantalo
BACKGROUND: Limited data suggest that the cerebrospinal fluid (CSF) Treponema pallidum particle agglutination assay (TPPA) is sensitive and a CSF Treponema pallidum hemagglutination assay (TPHA) titer ≥1:640 is specific for neurosyphilis diagnosis. METHODS: CSF-TPPA reactivity and titer were determined for a convenience sample of 191 CSFs from individuals enrolled in a study of CSF abnormalities in syphilis (training dataset). Sensitivity of a reactive test and specificity for reactivity at serial higher CSF dilutions was determined...
April 5, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28378284/microbial-community-compositions-in-the-gastrointestinal-tract-of-chinese-mongolian-sheep-using-illumina-miseq-sequencing-revealed-high-microbial-diversity
#14
Yan Zeng, Dong Zeng, Xueqin Ni, Hui Zhu, Ping Jian, Yi Zhou, Shuai Xu, Yicen Lin, Yang Li, Zhongqiong Yin, Kangcheng Pan, Bo Jing
Chinese Mongolian sheep are an important ruminant raised for wool and meat production. However, little is known about the microbiota of the gastrointestinal tract (GIT) of Chinese Mongolian sheep. To increase our understanding of the microbial community composition in the GIT of Chinese Mongolian sheep, microbiota of five sheep is investigate for the first time using the Illumina MiSeq platform. High microbial diversity was obtained from the GIT, and the microbiota exhibited a higher biodiversity in the stomach and large intestine than in the small intestine...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28363959/microbiota-analysis-of-environmental-slurry-and-its-potential-role-as-a-reservoir-of-bovine-digital-dermatitis-pathogens
#15
Kirstine Klitgaard, Mikael L Strube, Anastasia Isbrand, Tim K Jensen, Martin W Nielsen
At present, very little information exists regarding what role the environmental slurry may play as an infection reservoir and/or route of transmission for bovine digital dermatitis (DD), a disease which is a global problem in dairy herds. To investigate, if DD-related bacteria belong to the indigenous microbiota of the dairy herd environment, we used deep amplicon sequencing of the 16S rRNA gene in 135 slurry samples collected from different sites in 22 dairy farms, with and without DD-infected cows. Both the general bacterial populations as well as digital dermatitis-associated Treponema were targeted in this study...
March 31, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28359872/microbial-colonization-at-the-implant-abutment-interface-and-its-possible-influence-on-periimplantitis-a-systematic-review-and-meta-analysis
#16
REVIEW
Marco Tallarico, Luigi Canullo, Martina Caneva, Mutlu Özcan
PURPOSE: The aim of this systematic review and meta-analysis was to evaluate the microbial colonization at the implant-abutment interfaces (IAI) on bone-level implants and to identify possible association with peri-implant conditions. STUDY SELECTION: The focus question aimed to answer whether two-piece osseointegrated implants, in function for at least 1 year, in human, relate to higher bacterial count and the onset of periimplantitis, compared to healthy peri-implant conditions...
March 27, 2017: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/28357551/changes-in-the-microbial-community-during-repeated-anaerobic-microbial-dechlorination-of-pentachlorophenol
#17
Hui Tong, Manjia Chen, Fangbai Li, Chengshuai Liu, Changzhong Liao
Pentachlorophenol (PCP) has been widely used as a pesticide in paddy fields and has imposed negative ecological effect on agricultural soil systems, which are in typically anaerobic conditions. In this study, we investigated the effect of repeated additions of PCP to paddy soil on the microbial communities under anoxic conditions. Acetate was added as the carbon source to induce and accelerate cycles of the PCP degradation. A maximum degradation rate occurred at the 11th cycle, which completely transformed 32...
March 29, 2017: Biodegradation
https://www.readbyqxmd.com/read/28357375/syphilis-re-emergence-of-an-old-foe
#18
REVIEW
Lola V Stamm
Syphilis is caused by infection with Treponema pallidum subsp. pallidum, a not-yet-cultivable spiral-shaped bacterium that is usually transmitted by sexual contact with an infected partner or by an infected pregnant woman to her fetus. There is no vaccine to prevent syphilis. Diagnosis and treatment of infected individuals and their contacts is key to syphilis control programs that also include sex education and promotion of condom use to prevent infection. Untreated syphilis can progress through four stages: primary (chancre, regional lymphadenopathy), secondary (disseminated skin eruptions, generalized lymphadenopathy), latent (decreased re-occurrence of secondary stage manifestations, absence of symptoms), and tertiary (gummas, cardiovascular syphilis and late neurological symptoms)...
June 27, 2016: Microbial Cell
https://www.readbyqxmd.com/read/28338081/a-distinct-bacterial-dysbiosis-associated-skin-inflammation-in-ovine-footrot
#19
Grazieli Maboni, Adam Blanchard, Sara Frosth, Ceri Stewart, Richard Emes, Sabine Tötemeyer
Ovine footrot is a highly prevalent bacterial disease caused by Dichelobacter nodosus and characterised by the separation of the hoof horn from the underlying skin. The role of innate immune molecules and other bacterial communities in the development of footrot lesions remains unclear. This study shows a significant association between the high expression of IL1β and high D. nodosus load in footrot samples. Investigation of the microbial population identified distinct bacterial populations in the different disease stages and also depending on the level of inflammation...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28331333/the-risk-reduction-of-recurrent-periodontal-pathogens-of-local-application-minocycline-hcl-2-gel-used-as-an-adjunct-to-scaling-and-root-planing-for-chronic-periodontitis-treatment
#20
Y Soeroso, T Akase, H Sunarto, Y Kemal, R Salim, M Octavia, A Viandita, J Setiawan, B M Bachtiar
BACKGROUND: The aim of this study was to evaluate the clinical and microbiological effects of local application minocycline HCl 2% gel, used as an adjunct to scaling and root planing (SRP) for treatment of chronic periodontitis (CP). CP is an inflammation of periodontal tissue that is caused mainly by bacterial infection, where periodontal destruction such as loss of attachment and bone destruction occurred. METHODS: A total of 81 subjects with moderate to severe periodontitis whose baseline clinical attachment loss (CAL) was ≥4 mm were randomly assigned to receive SRP alone (control group, N=39) or SRP followed by four times of local application of minocycline HCl gel (Periocline) once a week (test group, N=42)...
2017: Therapeutics and Clinical Risk Management
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