keyword
MENU ▼
Read by QxMD icon Read
search

Gore

keyword
https://www.readbyqxmd.com/read/29678664/erosion-of-polytetrafluoroethylene-gore-tex%C3%A2-sling-over-20-years-after-placement-for-stress-urinary-incontinence
#1
Julie W Cheng, Andrea Staack
As synthetic material has evolved to improve both the efficacy and biocompatibility of suburethral slings, soft polypropylene slings are currently the gold standard for treatment of stress urinary incontinence. However, reports of complications beyond 10 years are limited and patients can nevertheless present with erosion and other complications from other sling materials that have been used in the past. We present a case of synthetic sling erosion 21 years after placement of a polytetrafluoroethylene sling (Gore-tex®)...
April 17, 2018: Urology
https://www.readbyqxmd.com/read/29676026/selective-inversion-recovery-quantitative-magnetization-transfer-brain-mri-at-7t-clinical-and-postmortem-validation-in-multiple-sclerosis
#2
Francesca Bagnato, Simon Hametner, Giulia Franco, Siddharama Pawate, Subramaniam Sriram, Hans Lassmann, John Gore, Seth E Smith, Richard Dortch
BACKGROUND AND PURPOSE: An imaging biomarker of myelin integrity is an unmet need in multiple sclerosis (MS). Selective inversion recovery (SIR) quantitative magnetization transfer imaging (qMT) provides assays of myelin content in the human brain. We previously translated the SIR method to 7T and incorporated a rapid turbo field echo (TFE) readout for whole-brain imaging within clinically acceptable scan times. We herein provide histological validation and test in vivo feasibility and applicability of the SIR-TFE protocol in MS...
April 19, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29675441/acute-bilateral-lower-extremity-paralysis-secondary-to-acute-thrombosis-of-an-infrarenal-abdominal-aortic-aneurysm
#3
T Joseph Watson, W Kurtis Childers, Lindsey Haga, John Calaitges
We present the case of a 64-year-old male who presented to the emergency department with bilateral limb ischemia and paralysis for approximately 1 hour. Computed tomographic angiography demonstrated occlusion of the infrarenal aorta beginning just above the patient's known abdominal aortic aneurysm (AAA) and extending into both common iliac arteries. He was emergently treated via open repair of the AAA with a Gore-Tex tube graft, bilateral common iliac thrombectomies, and bilateral lower extremity four-compartment fasciotomies...
June 2017: Aorta (Stamford, Conn.)
https://www.readbyqxmd.com/read/29673333/protocol-for-the-chord-project-community-health-outreach-to-reduce-diabetes-a-cluster-randomized-community-health-worker-trial-to-prevent-diabetes
#4
Nadia Islam, Thomas Gepts, Isaac Lief, Radhika Gore, Natalie Levy, Michael Tanner, Yixin Fang, Scott E Sherman, Mark D Schwartz
BACKGROUND: Type 2 diabetes mellitus (DM) affects 9.4% of US adults and children, while another 33.9% of Americans are at risk of DM. Health care institutions face many barriers to systematically delivering the preventive care needed to decrease DM incidence. Community health workers (CHWs) may, as frontline public health workers bridging clinic and community, help overcome these challenges. This paper presents the protocol for a pragmatic, cluster-randomized trial integrating CHWs into two primary care clinics to support DM prevention for at-risk patients...
April 19, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29670097/random-sequences-rapidly-evolve-into-de-novo-promoters
#5
Avihu H Yona, Eric J Alm, Jeff Gore
How new functions arise de novo is a fundamental question in evolution. We studied de novo evolution of promoters in Escherichia coli by replacing the lac promoter with various random sequences of the same size (~100 bp) and evolving the cells in the presence of lactose. We find that ~60% of random sequences can evolve expression comparable to the wild-type with only one mutation, and that ~10% of random sequences can serve as active promoters even without evolution. Such a short mutational distance between random sequences and active promoters may improve the evolvability, yet may also lead to accidental promoters inside genes that interfere with normal expression...
April 18, 2018: Nature Communications
https://www.readbyqxmd.com/read/29669114/current-predictive-indices-and-nomograms-to-enable-personalization-of-radiation-therapy-for-patients-with-secondary-malignant-neoplasms-of-the-central-nervous-system-a-review
#6
Lucas Gilbride, Malika Siker, Joseph Bovi, Elizabeth Gore, Christopher Schultz, William A Hall
The proper treatment of brain metastases continues to be a challenge for oncologists given the variability of individual patients' prognoses and the variety of treatment options available to address brain metasteses. There have been efforts since the 1990s to develop prognostic indices and nomograms to help clinicians determine the best approach for individuals with secondary malignant neoplasms of the central nervous system. A literature search was performed to identify the existing prognostic tools published between January 1995 and January 2017...
May 1, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29668886/the-hard-road-to-data-interpretation-the-road-is-hard-too-for-the-patient
#7
J Gore-Booth
No abstract text is available yet for this article.
April 14, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29667455/beliefs-and-practice-patterns-in-hyperleukocytosis-management-in-acute-myeloid-leukemia-a-large-u-s-web-based-survey
#8
Maximilian Stahl, Alexander Pine, Jeanne E Hendrickson, Mark R Litzow, Selina M Luger, Richard M Stone, Harry P Erba, Tae Kon Kim, Mikkael A Sekeres, David P Steensma, Rami S Komrokji, Steven D Gore, Amer M Zeidan
No abstract text is available yet for this article.
April 18, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29667070/differences-in-use-of-government-subsidised-mental-health-services-by-men-and-women-with-psychological-distress-a-study-of-229-628-australians-aged-45-years-and-over
#9
Xenia Dolja-Gore, Deborah Loxton, Catherine D'Este, Fiona Blyth, Julie Byles
This study examined factors associated with use of government subsidised mental health services by 229,628 men and women from the Sax Institute's 45 and Up Study. Logistical regression models assessed use of mental health services by gender and according to level of psychological distress. Approximately equal proportion of men and women had high psychological distress scores (approximately 7%) but only 7% of these men and 11% of these women used services. Use was associated with predisposing (younger age and higher education), enabling (private health insurance) and need factors (higher psychological distress scores)...
April 17, 2018: Community Mental Health Journal
https://www.readbyqxmd.com/read/29665666/-early-results-of-fenestrated-endovascular-aortic-repair-for-the-treatment-of-patients-with-thoracoabdominal-pathologies
#10
J C Zhu, X C Dai, Y D Luo, H L Fan, Z Feng, Y W Zhang, F G Hu
Objective: To evaluate the early results of fenestrated endovascular aortic repair (FEVAR) using physician-modified stent grafts (PMSGs) for the treatment of patients with thoracoabdominal pathologies. Methods: Nineteen consecutive patients who underwent FEVAR using PMSGs between April 2012 and September 2017 were retrospectively reviewed. The modality of FEVAR technique was assessed, perioperative clinical data was recorded and the early results were evaluated. Results: Indications were thoracoabdominal aortic pathologies, including juxtarenal abdominal aortic aneurysm (JAAA) ( n =12), chronic thoracoabdominal aortic dissection with aneurysmal dilatation ( n =3), thoracoabdominal aortic aneurysm (TAAA) ( n =1), infrarenal AAA with an accessory renal artery in the segment of the aneurysmal neck ( n =2) and type Ⅰ endoleak after EVAR for AAA( n =1)...
March 27, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29664486/heparin-induced-tau-filaments-are-structurally-heterogeneous-and-differ-from-alzheimer-s-disease-filaments
#11
Yann Fichou, Michael Vigers, Andrew K Goring, Neil A Eschmann, Songi Han
Alzheimer's disease (AD) is characterized by the presence of tau filaments in the brain whose structure was recently solved. The formation of AD filaments is routinely modeled in vitro by mixing tau with heparin. This study shows that heparin-induced tau filaments are markedly different from the AD filaments and are highly heterogeneous.
April 17, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29662223/ecological-suicide-in-microbes
#12
Christoph Ratzke, Jonas Denk, Jeff Gore
The growth and survival of organisms often depend on interactions between them. In many cases, these interactions are positive and caused by a cooperative modification of the environment. Examples are the cooperative breakdown of complex nutrients in microbes or the construction of elaborate architectures in social insects, in which the individual profits from the collective actions of her peers. However, organisms can similarly display negative interactions by changing the environment in ways that are detrimental for them, for example by resource depletion or the production of toxic byproducts...
April 16, 2018: Nature Ecology & Evolution
https://www.readbyqxmd.com/read/29661788/germline-tissues-for-optimal-somatic-variant-detection-in-myelodysplastic-syndromes-mds
#13
Eric Padron, Markus C Ball, Jamie K Teer, Jeffrey S Painter, Sean J Yoder, Chaomei Zhang, Ling Zhang, Lynn C Moscinski, Dana E Rollison, Steven D Gore, Rafael Bejar, Matthew J Walter, Mikkael A Sekeres, Rami S Komrokji, Pearlie K Epling-Burnette
No abstract text is available yet for this article.
April 16, 2018: Blood
https://www.readbyqxmd.com/read/29656895/tracking-cancer-evolution-reveals-constrained-routes-to-metastases-tracerx-renal
#14
Samra Turajlic, Hang Xu, Kevin Litchfield, Andrew Rowan, Tim Chambers, Jose I Lopez, David Nicol, Tim O'Brien, James Larkin, Stuart Horswell, Mark Stares, Lewis Au, Mariam Jamal-Hanjani, Ben Challacombe, Ashish Chandra, Steve Hazell, Claudia Eichler-Jonsson, Aspasia Soultati, Simon Chowdhury, Sarah Rudman, Joanna Lynch, Archana Fernando, Gordon Stamp, Emma Nye, Faiz Jabbar, Lavinia Spain, Sharanpreet Lall, Rosa Guarch, Mary Falzon, Ian Proctor, Lisa Pickering, Martin Gore, Thomas B K Watkins, Sophia Ward, Aengus Stewart, Renzo DiNatale, Maria F Becerra, Ed Reznik, James J Hsieh, Todd A Richmond, George F Mayhew, Samantha M Hill, Catherine D McNally, Carol Jones, Heidi Rosenbaum, Stacey Stanislaw, Daniel L Burgess, Nelson R Alexander, Charles Swanton
Clear-cell renal cell carcinoma (ccRCC) exhibits a broad range of metastatic phenotypes that have not been systematically studied to date. Here, we analyzed 575 primary and 335 metastatic biopsies across 100 patients with metastatic ccRCC, including two cases sampledat post-mortem. Metastatic competence was afforded by chromosome complexity, and we identify 9p loss as a highly selected event driving metastasis and ccRCC-related mortality (p = 0.0014). Distinct patterns of metastatic dissemination were observed, including rapid progression to multiple tissue sites seeded by primary tumors of monoclonal structure...
April 9, 2018: Cell
https://www.readbyqxmd.com/read/29656894/deterministic-evolutionary-trajectories-influence-primary-tumor-growth-tracerx-renal
#15
Samra Turajlic, Hang Xu, Kevin Litchfield, Andrew Rowan, Stuart Horswell, Tim Chambers, Tim O'Brien, Jose I Lopez, Thomas B K Watkins, David Nicol, Mark Stares, Ben Challacombe, Steve Hazell, Ashish Chandra, Thomas J Mitchell, Lewis Au, Claudia Eichler-Jonsson, Faiz Jabbar, Aspasia Soultati, Simon Chowdhury, Sarah Rudman, Joanna Lynch, Archana Fernando, Gordon Stamp, Emma Nye, Aengus Stewart, Wei Xing, Jonathan C Smith, Mickael Escudero, Adam Huffman, Nik Matthews, Greg Elgar, Ben Phillimore, Marta Costa, Sharmin Begum, Sophia Ward, Max Salm, Stefan Boeing, Rosalie Fisher, Lavinia Spain, Carolina Navas, Eva Grönroos, Sebastijan Hobor, Sarkhara Sharma, Ismaeel Aurangzeb, Sharanpreet Lall, Alexander Polson, Mary Varia, Catherine Horsfield, Nicos Fotiadis, Lisa Pickering, Roland F Schwarz, Bruno Silva, Javier Herrero, Nick M Luscombe, Mariam Jamal-Hanjani, Rachel Rosenthal, Nicolai J Birkbak, Gareth A Wilson, Orsolya Pipek, Dezso Ribli, Marcin Krzystanek, Istvan Csabai, Zoltan Szallasi, Martin Gore, Nicholas McGranahan, Peter Van Loo, Peter Campbell, James Larkin, Charles Swanton
The evolutionary features of clear-cell renal cell carcinoma (ccRCC) have not been systematically studied to date. We analyzed 1,206 primary tumor regions from 101 patients recruited into the multi-center prospective study, TRACERx Renal. We observe up to 30 driver events per tumor and show that subclonal diversification is associated with known prognostic parameters. By resolving the patterns of driver event ordering, co-occurrence, and mutual exclusivity at clone level, we show the deterministic nature of clonal evolution...
April 11, 2018: Cell
https://www.readbyqxmd.com/read/29656891/timing-the-landmark-events-in-the-evolution-of-clear-cell-renal-cell-cancer-tracerx-renal
#16
Thomas J Mitchell, Samra Turajlic, Andrew Rowan, David Nicol, James H R Farmery, Tim O'Brien, Inigo Martincorena, Patrick Tarpey, Nicos Angelopoulos, Lucy R Yates, Adam P Butler, Keiran Raine, Grant D Stewart, Ben Challacombe, Archana Fernando, Jose I Lopez, Steve Hazell, Ashish Chandra, Simon Chowdhury, Sarah Rudman, Aspasia Soultati, Gordon Stamp, Nicos Fotiadis, Lisa Pickering, Lewis Au, Lavinia Spain, Joanna Lynch, Mark Stares, Jon Teague, Francesco Maura, David C Wedge, Stuart Horswell, Tim Chambers, Kevin Litchfield, Hang Xu, Aengus Stewart, Reza Elaidi, Stéphane Oudard, Nicholas McGranahan, Istvan Csabai, Martin Gore, P Andrew Futreal, James Larkin, Andy G Lynch, Zoltan Szallasi, Charles Swanton, Peter J Campbell
Clear cell renal cell carcinoma (ccRCC) is characterized by near-universal loss of the short arm of chromosome 3, deleting several tumor suppressor genes. We analyzed whole genomes from 95 biopsies across 33 patients with clear cell renal cell carcinoma. We find hotspots of point mutations in the 5' UTR of TERT, targeting a MYC-MAX-MAD1 repressor associated with telomere lengthening. The most common structural abnormality generates simultaneous 3p loss and 5q gain (36% patients), typically through chromothripsis...
April 4, 2018: Cell
https://www.readbyqxmd.com/read/29649620/allogeneic-hematopoietic-cell-transplantation-following-the-use-of-hypomethylating-agents-among-patients-with-relapsed-or-refractory-aml-findings-from-an-international-retrospective-study
#17
Maximilian Stahl, Michelle DeVeaux, Pau Montesinos Fernández, Raphaël Itzykson, Ellen K Ritchie, Mikkael A Sekeres, Navneet Majhail, John Barnard, Nikolai A Podoltsev, Andrew Brunner, Rami S Komrokji, Vijaya R Bhatt, Aref Al-Kali, Thomas Cluzeau, Valeria Santini, Gail J Roboz, Pierre Fenaux, Mark Litzow, Amir T Fathi, Sarah Perreault, Tae Kon Kim, Thomas Prebet, Norbert Vey, Vivek Verma, Guido Kobbe, Juan Bergua, Josefina Serrano, Steven D Gore, Amer M Zeidan
No abstract text is available yet for this article.
April 9, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29648581/multiple-sclerosis-lesions-affect-intrinsic-functional-connectivity-of-the-spinal-cord
#18
Benjamin N Conrad, Robert L Barry, Baxter P Rogers, Satoshi Maki, Arabinda Mishra, Saakshi Thukral, Subramaniam Sriram, Aashim Bhatia, Siddharama Pawate, John C Gore, Seth A Smith
Patients with multiple sclerosis present with focal lesions throughout the spinal cord. There is a clinical need for non-invasive measurements of spinal cord activity and functional organization in multiple sclerosis, given the cord's critical role in the disease. Recent reports of spontaneous blood oxygenation level-dependent fluctuations in the spinal cord using functional MRI suggest that, like the brain, cord activity at rest is organized into distinct, synchronized functional networks among grey matter regions, likely related to motor and sensory systems...
April 10, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29643738/an-alternative-technique-in-the-control-of-massive-presacral-rectal-bleeding-fixation-of-gore-tex-%C3%A2-aortic-patch
#19
Mustafa Ozsoy, Zehra Ozsoy, Suleyman Sahin, Yüksel Arikan
The presacral venous system is located under the pelvic fascia covering the anterior of the sacrum and consists of two lateral sacral veins, middle sacral vein, and the veins that communicate them. The presacral venous system can be easily damaged and causes serious bleeding which is difficult to control and may cause intraoperative mortality. Its incidence varies between 3% and 9.4%. Although several methods have been tried to control presacral bleeding, the definitive method of treatment has not yet been identified...
January 2018: Nigerian Journal of Surgery: Official Publication of the Nigerian Surgical Research Society
https://www.readbyqxmd.com/read/29627364/animal-models-of-cholangiocarcinoma
#20
REVIEW
Emilien Loeuillard, Samantha R Fischbach, Gregory J Gores, Sumera Rizvi
Cholangiocarcinoma (CCA) is an aggressive biliary tract malignancy with a poor overall prognosis. There is a critical need to develop effective targeted therapies for the treatment of this lethal disease. In an effort to address this challenge, preclinical in vivo studies have become paramount in understanding CCA carcinogenesis, progression, and therapy. Various CCA animal models exist including carcinogen-based models in which animals develop CCA after exposure to a carcinogen, genetically engineered mouse models in which genetic changes are induced in mice leading to CCA, murine syngeneic orthotopic models, as well as xenograft tumors derived from xenotransplantation of CCA cells, organoids, and patient-derived tissue...
April 5, 2018: Biochimica et Biophysica Acta
keyword
keyword
12224
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"