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https://www.readbyqxmd.com/read/29036428/exocyst-exosomes-and-autophagy-in-the-regulation-of-brassicaceae-pollen-stigma-interactions
#1
Daphne R Goring
Brassicaceae pollen-stigma interactions have been extensively studied in Brassica and Arabidopsis species to identify cellular events triggered in the stigmatic papillae by pollen contact. Compatible pollinations are linked to the activation of basal cellular responses in the stigmatic papillae, which include calcium gradients, actin networks, and polarized secretion. The occurrence of these cellular events in stigmatic papillae coincides with the stages of pollen hydration and pollen tube entry into the stigmatic papillar cell wall...
September 27, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29034009/a-multicenter-randomized-study-of-decitabine-as-epigenetic-priming-with-induction-chemotherapy-in-children-with-aml
#2
Lia Gore, Timothy J Triche, Jason E Farrar, Daniel Wai, Christophe Legendre, Gerald C Gooden, Winnie S Liang, John Carpten, David Lee, Frank Alvaro, Margaret E Macy, Carola Arndt, Philip Barnette, Todd Cooper, Laura Martin, Aru Narendran, Jessica Pollard, Soheil Meshinchi, Jessica Boklan, Robert J Arceci, Bodour Salhia
BACKGROUND: Decitabine is a deoxycytidine nucleoside derivative inhibitor of DNA-methyltransferases, which has been studied extensively and is approved for myelodysplastic syndrome in adults but with less focus in children. Accordingly, we conducted a phase 1 multicenter, randomized, open-label study to evaluate decitabine pre-treatment before standard induction therapy in children with newly diagnosed AML to assess safety and tolerability and explore a number of biologic endpoints. RESULTS: Twenty-four patients were fully assessable for all study objectives per protocol (10 in Arm A = epigenetic priming induction, 14 in Arm B = standard induction)...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/29029682/a-comparison-of-veterans-who-repeat-versus-who-do-not-repeat-a-course-of-manualized-cognitive-behavioral-therapy-for-posttraumatic-stress-disorder
#3
Jeremiah A Schumm, Nicole D Pukay-Martin, Whitney L Gore
Despite evidence that cognitive-behavioral therapy (CBT) for posttraumatic stress disorder (PTSD) is effective, some individuals do not experience clinically significant reduction or remission of their PTSD symptoms. These individuals may return for additional PTSD-focused psychotherapy. However, there is no research to know whether PTSD treatment repeaters have worse symptoms prior to the initial treatment episode or display differences in other pretreatment characteristics versus nonrepeaters. Research is also needed to explore whether treatment repeaters exhibit PTSD symptom changes during an initial or second course of treatment...
November 2017: Behavior Therapy
https://www.readbyqxmd.com/read/29027252/the-athlete-s-hematological-response-to-hypoxia-a-meta-analysis-on-the-influence-of-altitude-exposure-on-key-biomarkers-of-erythropoiesis
#4
Louisa M Lobigs, Ken Sharpe, Laura A Garvican-Lewis, Christopher J Gore, Peter Peeling, Brian Dawson, Yorck O Schumacher
No abstract text is available yet for this article.
October 13, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/29023828/impact-of-surveillance-for-hepatocellular-carcinoma-on-survival-in-patients-with-compensated-cirrhosis
#5
Ju Dong Yang, Ajitha Mannalithara, Andrew J Piscitello, John B Kisiel, Gregory J Gores, Lewis R Roberts, W Ray Kim
Surveillance for hepatocellular carcinoma (HCC) has been recommended in patients with cirrhosis. In this work, we examine the extent to which the competing risk of hepatic decompensation influences the benefit of HCC surveillance, by investigating the impact of availability of liver transplantation (LTx) and rate of progression of hepatic decompensation on survival gain from HCC surveillance. A multistate Markov model was constructed simulating a cohort of 50-year old patients with compensated cirrhosis. The primary outcome of interest was all-cause and HCC-specific mortality...
October 12, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29018169/randomized-phase-ii-trial-of-parsatuzumab-anti-egfl7-or-placebo-in-combination-with-folfox-and-bevacizumab-for-first-line-metastatic-colorectal-cancer
#6
Rocío García-Carbonero, Eric van Cutsem, Fernando Rivera, Jacek Jassem, Ira Gore, Niall Tebbutt, Fadi Braiteh, Guillem Argiles, Zev A Wainberg, Roel Funke, Maria Anderson, Bruce McCall, Mark Stroh, Eric Wakshull, Priti Hegde, Weilan Ye, Daniel Chen, Ilsung Chang, Ina Rhee, Herbert Hurwitz
No abstract text is available yet for this article.
October 2017: Oncologist
https://www.readbyqxmd.com/read/28994423/cholangiocarcinoma-evolving-concepts-and-therapeutic-strategies
#7
REVIEW
Sumera Rizvi, Shahid A Khan, Christopher L Hallemeier, Robin K Kelley, Gregory J Gores
Cholangiocarcinoma is a disease entity comprising diverse epithelial tumours with features of cholangiocyte differentiation: cholangiocarcinomas are categorized according to anatomical location as intrahepatic (iCCA), perihilar (pCCA), or distal (dCCA). Each subtype has a distinct epidemiology, biology, prognosis, and strategy for clinical management. The incidence of cholangiocarcinoma, particularly iCCA, has increased globally over the past few decades. Surgical resection remains the mainstay of potentially curative treatment for all three disease subtypes, whereas liver transplantation after neoadjuvant chemoradiation is restricted to a subset of patients with early stage pCCA...
October 10, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28993404/an-internet-supported-school-physical-activity-intervention-in-low-socioeconomic-status-communities-results-from-the-activity-and-motivation-in-physical-education-amped-cluster-randomised-controlled-trial
#8
Chris Lonsdale, Aidan Lester, Katherine B Owen, Rhiannon L White, Louisa Peralta, Morwenna Kirwan, Thierno M O Diallo, Anthony J Maeder, Andrew Bennie, Freya MacMillan, Gregory S Kolt, Nikos Ntoumanis, Jennifer M Gore, Ester Cerin, Dylan P Cliff, David R Lubans
OBJECTIVE: Quality physical education (PE) is the cornerstone of comprehensive school physical activity (PA) promotion programmes. We tested the efficacy of a teacher professional learning intervention, delivered partially via the internet, designed to maximise opportunities for students to be active during PE lessons and enhance adolescents' motivation towards PE and PA. METHODS: A two-arm cluster randomised controlled trial with teachers and Grade 8 students from secondary schools in low socioeconomic areas of Western Sydney, Australia...
October 9, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28990693/impact-of-medialization-laryngoplasty-on-dynamic-nanomechanical-vocal-fold-structure-properties
#9
Gregory R Dion, Peter A Benedict, Paulo G Coelho, Milan R Amin, Ryan C Branski
OBJECTIVES/HYPOTHESIS: Although the primary goal of medialization laryngoplasty is to improve glottic closure, implant placement is also likely to alter the biomechanical properties of the vocal fold (VF). We sought to employ novel, nanoscale technology to quantify these properties following medialization based on the hypothesis that different medialization materials will likely yield differential biomechanical effects. STUDY DESIGN: Ex vivo. METHODS: Nine pig larynges were divided into three groups: control, Silastic (Dow Corning, Midland, Michigan, U...
October 9, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28988681/pathophysiology-of-leishmania-infection-during-pregnancy
#10
REVIEW
Brandon A Berger, Allison H Bartlett, Nancy Gore Saravia, Norma Galindo Sevilla
The pathological processes resulting from parasitic infection are known to have important impacts on the mother child dyad during pregnancy. The roles of parasite transmission and the maternal immune response have been described in diseases such as malaria, toxoplasmosis, and trypanosomiasis. However, the impact of parasites of the genus Leishmania, etiological agents of the neglected tropical diseases tegumentary leishmaniasis (TL) and visceral leishmaniasis (VL), is comparatively less well known, though it is an increasingly recognized concern for infected mothers and their fetuses...
October 4, 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/28987259/primary-sclerosing-cholangitis-what-the-gastroenterologist-and-hepatologist-needs-to-know
#11
REVIEW
Andrea A Gossard, Gregory J Gores
Primary sclerosing cholangitis (PSC) is a chronic, idiopathic biliary tract disease characterized by segmental strictures. The disease is progressive with no proven treatments and may eventually lead to cirrhosis and end-stage liver disease. Abrupt changes in liver biochemistries, pain, and/or cholangitis may suggest a dominant stricture amenable to endoscopic therapy or the development of cholangiocarcinoma. Patients with PSC are at increased risk of cholangiocarcinoma. There is a strong association with inflammatory bowel disease, and an associated increased risk of colorectal cancer...
November 2017: Clinics in Liver Disease
https://www.readbyqxmd.com/read/28983249/therapeutic-potential-and-pharmaceutical-development-of-thymoquinone-a-multitargeted-molecule-of-natural-origin
#12
REVIEW
Sameer N Goyal, Chaitali P Prajapati, Prashant R Gore, Chandragouda R Patil, Umesh B Mahajan, Charu Sharma, Sandhya P Talla, Shreesh K Ojha
Thymoquinone, a monoterpene molecule is chemically known as 2-methyl-5-isopropyl-1, 4-benzoquinone. It is abundantly present in seeds of Nigella sativa L. that is popularly known as black cumin or black seed and belongs to the family Ranunculaceae. A large number of studies have revealed that thymoquinone is the major active constituent in N. sativa oil this constituent is responsible for the majority of the pharmacological properties. The beneficial organoprotective activities of thymoquinone in experimental animal models of different human diseases are attributed to the potent anti-oxidant and anti-inflammatory properties...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28982135/changes-in-aortic-pulse-wave-velocity-of-four-thoracic-aortic-stent-grafts-in-an-ex-vivo-porcine-model
#13
Hector W L de Beaufort, Margherita Coda, Michele Conti, Theodorus M J van Bakel, Foeke J H Nauta, Ettore Lanzarone, Frans L Moll, Joost A van Herwaarden, Ferdinando Auricchio, Santi Trimarchi
OBJECTIVES: Thoracic endovascular aortic repair (TEVAR) has been shown to lead to increased aortic stiffness. The aim of this study was to investigate the effect of stent graft type and stent graft length on aortic stiffness in a controlled, experimental setting. METHODS: Twenty porcine thoracic aortas were connected to a pulsatile mock loop system. Intraluminal pressure was recorded at two sites in order to measure pulse wave velocity (PWV) for each aorta: before stent graft deployment (t1); after deployment of a 100-mm long stent graft (t2); and after distal extension through deployment of a second 100-mm long stent graft (t3)...
2017: PloS One
https://www.readbyqxmd.com/read/28980021/comparison-of-strength-of-sacrocolpopexy-mesh-attachment-using-barbed-and-nonbarbed-sutures
#14
Marjorie L Pilkinton, Gregory C Levine, Laura Bennett, Harvey A Winkler, Dara F Shalom, Peter S Finamore
INTRODUCTION AND HYPOTHESIS: We aimed to assess the pull-out strength of barbed and nonbarbed sutures used in sacrocolpopexy mesh fixation. We hypothesized there are no differences in the force needed to dislodge mesh from tissue using barbed and nonbarbed sutures of similar size. METHODS: Using the rectus fascia of three unembalmed cadavers, a 6 × 3 cm strip of polypropylene mesh was anchored to the fascia with sutures. The barbed sutures investigated were 2-0 V-Loc 180 (nine trials) and 3-0 bidirectional Quill™ SRS PDO (five trials)...
October 4, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28972265/efficacy-of-a-web-based-intervention-for-concerned-spouses-of-service-members-and-veterans-with-alcohol-misuse
#15
Karen Chan Osilla, Thomas E Trail, Eric R Pedersen, Kristie L Gore, Anagha Tolpadi, Lindsey M Rodriguez
Concerned partners (CPs) of service members and veterans who misuse alcohol face help-seeking barriers and mental health problems. We used multiple regression to evaluate the efficacy of Partners Connect, a four-session web-based intervention (WBI) to address military CPs' mental health and communication. We randomized 312 CPs to the WBI or a control group. Five months later, WBI CPs reported significant reductions in their anxiety and increases in their social support compared to control CPs. Intervention dose was also associated with improved WBI CP outcomes...
October 3, 2017: Journal of Marital and Family Therapy
https://www.readbyqxmd.com/read/28970338/novel-loci-underlie-natural-variation-in-vitamin-e-levels-in-maize-grain
#16
Christine H Diepenbrock, Catherine B Kandianis, Alexander E Lipka, Maria Magallanes-Lundback, Brieanne Vaillancourt, Elsa Góngora-Castillo, Jason G Wallace, Jason Cepela, Alex Mesberg, Peter Bradbury, Daniel C Ilut, Maria Mateos-Hernandez, John Hamilton, Brenda F Owens, Tyler Tiede, Edward S Buckler, Torbert Rocheford, C Robin Buell, Michael A Gore, Dean DellaPenna
Tocopherols, tocotrienols and plastochromanols (collectively termed tocochromanols) are lipid-soluble antioxidants synthesized by all plants. Their dietary intake, primarily from seed oils, provides vitamin E and other health benefits. Tocochromanol biosynthesis has been dissected in the dicot Arabidopsis thaliana, which has green, photosynthetic seeds, but our understanding of tocochromanol accumulation in major crops, whose seeds are non-photosynthetic, remains limited. To understand the genetic control of tocochromanols in grain, we conducted a joint linkage and genome-wide association study in the 5,000-line U...
October 2, 2017: Plant Cell
https://www.readbyqxmd.com/read/28969413/the-eternal-enigma-in-prostatic-biopsy-access-route
#17
Andrea Fabiani, Emanuele Principi, Alessandra Filosa, Lucilla Servi
Dear Editors,We read with interest the article by Di Franco and co-workers (1). The introduction of prostatic magnetic resonance and the relative fusion-biopsy have not yet allowed the expected improvements in prostate biopsy. To our knowledge, there are no works that demonstrate the superiority of fusion techniques on the remaining ultrasound guided prostate biopsies that are still the widely used in the diagnosis of prostate cancer. Furthemore, these technologies are expensive exams and they are not yet available in all centers, especially in those minors...
October 3, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28968238/sex-differences-in-the-psychophysical-response-to-contact-heat-in-moderate-cognitive-impairment-alzheimer-s-disease-a-cross-sectional-brief-report
#18
Ronald L Cowan, Paul A Beach, Sebastian W Atalla, Mary S Dietrich, Stephen P Bruehl, Jie Deng, Jinjiao Wang, Paul A Newhouse, John C Gore, Todd B Monroe
BACKGROUND: People with Alzheimer's disease (AD) report pain less frequently and receive less pain medication than people without AD. Recent studies have begun to elucidate how pain may be altered in those with AD. However, potential sex differences in pain responsiveness have never been explored in these patients. It is unclear whether sex differences found in prior studies of healthy young and older individuals extend to people with AD. OBJECTIVE: The purpose of this study was to examine sex differences in the psychophysical response to experimental thermal pain in people with AD...
September 29, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28968170/broadening-eligibility-criteria-to-make-clinical-trials-more-representative-american-society-of-clinical-oncology-and-friends-of-cancer-research-joint-research-statement
#19
Edward S Kim, Suanna S Bruinooge, Samantha Roberts, Gwynn Ison, Nancy U Lin, Lia Gore, Thomas S Uldrick, Stuart M Lichtman, Nancy Roach, Julia A Beaver, Rajeshwari Sridhara, Paul J Hesketh, Andrea M Denicoff, Elizabeth Garrett-Mayer, Eric Rubin, Pratik Multani, Tatiana M Prowell, Caroline Schenkel, Marina Kozak, Jeff Allen, Ellen Sigal, Richard L Schilsky
Purpose The primary purposes of eligibility criteria are to protect the safety of trial participants and define the trial population. Excessive or overly restrictive eligibility criteria can slow trial accrual, jeopardize the generalizability of results, and limit understanding of the intervention's benefit-risk profile. Methods ASCO, Friends of Cancer Research, and the US Food and Drug Administration examined specific eligibility criteria (ie, brain metastases, minimum age, HIV infection, and organ dysfunction and prior and concurrent malignancies) to determine whether to modify definitions to extend trials to a broader population...
October 2, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28968169/modernizing-clinical-trial-eligibility-recommendations-of-the-american-society-of-clinical-oncology-friends-of-cancer-research-minimum-age-working-group
#20
Lia Gore, S Percy Ivy, Frank M Balis, Eric Rubin, Katherine Thornton, Martha Donoghue, Samantha Roberts, Suanna Bruinooge, Jennifer Ersek, Nancy Goodman, Caroline Schenkel, Gregory Reaman
Purpose Children have historically been excluded from first-in-human studies of promising new cancer drugs and later phase adult clinical trials. Delays in evaluation may result in off-label use without dosing information as the only access to new drugs. A multistakeholder workshop was convened in May 2016 by ASCO and Friends of Cancer Research to identify opportunities for when it would be scientifically appropriate to expand trial eligibility to include children younger than age 18 years in first-in-human and other adult cancer clinical trials...
October 2, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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