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https://www.readbyqxmd.com/read/28194307/vascular-plant-biodiversity-of-the-lower-coppermine-river-valley-and-vicinity-nunavut-canada-an-annotated-checklist-of-an-arctic-flora
#1
Jeffery M Saarela, Paul C Sokoloff, Roger D Bull
The Coppermine River in western Nunavut is one of Canada's great Arctic rivers, yet its vascular plant flora is poorly known. Here, we report the results of a floristic inventory of the lower Coppermine River valley and vicinity, including Kugluk (Bloody Falls) Territorial Park and the hamlet of Kugluktuk. The study area is approximately 1,200 km(2), extending from the forest-tundra south of the treeline to the Arctic coast. Vascular plant floristic data are based on a review of all previous collections from the area and more than 1,200 new collections made in 2014...
2017: PeerJ
https://www.readbyqxmd.com/read/28190860/activated-phosphoinositide-3-kinase-%C3%AE-syndrome-presenting-with-gut-associated-t-cell-lymphoproliferative-disease
#2
Hideto Teranishi, Masataka Ishimura, Yuuki Koga, Katsuhide Eguchi, Motoshi Sonoda, Tetsuko Kobayashi, Satoru Shiraishi, Kentaro Nakashima, Kouji Ikegami, Murasaki Aman, Hidetaka Yamamoto, Hidetoshi Takada, Shouichi Ohga
A 13-year-old boy was admitted to our hospital because of persistent diarrhea, abdominal pain, and bloody stools. The patient had experienced repeated hospitalizations for the treatment of respiratory infections since early childhood. Colonoscopic and pathological studies led to a diagnosis of gut-associated T-cell lymphoproliferative disease (T-cell LPD). Laboratory data showed T-lymphocytopenia (492/µl), increased serum IgG levels (1,984 mg/dl), and low serum antibody titers for specific pathogens. Combined immunodeficiency accompanied by T-LPD suggested the diagnosis of activated PI3Kδ syndrome (APDS)...
2017: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/28185626/prevalence-of-concomitant-acute-bacterial-meningitis-in-neonates-with-febrile-urinary-tract-infection-a-retrospective-cross-sectional-study
#3
Sowdhamini S Wallace, Danielle N Brown, Andrea T Cruz
OBJECTIVE: To describe the frequency of concomitant acute bacterial meningitis (ABM) in neonates with febrile urinary tract infection (UTI). STUDY DESIGN: This was a retrospective cross-sectional study from 2005 to 2013 of infants ≤30 days old evaluated in the emergency department of a quaternary care children's hospital with fever and laboratory-confirmed UTI. Definite ABM was defined as cerebrospinal fluid (CSF) culture with growth of pathogenic bacteria and probable ABM if pleocytosis with ≥ 20 white blood cell was present in an antibiotic-pretreated patient...
February 6, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28182338/evaluation-of-nested-polymerase-chain-reaction-and-immunoassay-for-rapid-diagnosis-of-clostridium-difficile-in-children-with-community-acquired-diarrhea
#4
Ahmed Elewa, Maysaa El Sayed-Zaki
BACKGROUND: Clostridium difficile (C. difficile) is a known pathogen associated with diarrhea especially in hospital acquired diarrhea. Yet, it is being recognized as a probable etiology for community acquired diarrhea. The aim of the present study was to detect the presence of C. difficile as a pathogen causing community acquired diarrhea in children and to verify the value of different laboratory methods for diagnosis, namely specific culture, immunoassay for toxin detection, and nested polymerase chain reaction (nested-PCR)...
February 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28176531/37th-british-mass-spectrometry-society-annual-meeting
#5
Patricia Wright, Christine Eckers
The 37th British Mass Spectrometry Society (BMSS) annual meeting took place over a brilliantly sunny 3 days by the sea in the historic Eastbourne Winter Gardens on the south coast of England. It was held between 13 and 15 September 2016. Two-hundred attendees enjoyed a conference covering all aspects of MS with speakers drawn from across Europe and North America. The BMSS is particularly proud of the encouragement it offers students and early career scientists, both financially in the form of travel grants and also in terms of opportunities to present at an international level in a supportive atmosphere...
February 8, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28170195/are-mesenchymal-stem-cells-so-bloody-great-after-all
#6
Stephanie J Marfy-Smith, Claire E Clarkin
This Perspective discusses some activities of mesenchymal stem cells (MSCs) in the context of angiogenesis, focusing on contrasting effects that could call into question the extent to which MSCs can be used clinically in the future. We report on the antiangiogenic/antiproliferative effects of specific MSC populations (including bone marrow MSCs), their paracrine activity, tissue heterogeneity, and endothelial cell interactions. Also discussed are what could lead to contrasting effects of the influence of MSCs in regulating angiogenesis, pointing to some negative effects of these cells...
January 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28161190/a-spontaneous-high-grade-undifferentiated-mammary-carcinoma-in-a-seven-week-old-female-rat
#7
Ana I Faustino-Rocha, Adelina Gama, Paula A Oliveira, Antonieta Alvarado, Rita Ferreira, Mário Ginja
The present work describes a rare case of a spontaneous high-grade carcinoma in a seven-week-old Sprague-Dawley female rat that had been included in the control group of an assay of mammary carcinogenesis. The mass was detected at 50days of age, it grown quickly and the animal was humanely sacrificed eight days later. The tumor was located in the left cervical region, in the vicinity of the left submandibular and sublingual glands. It was soft and reddish and had several dens with a bloody content. The tumor was PAS negative and exhibited immunostaining for ER-α...
February 1, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28159385/tolerance-development-in-food-protein-induced-allergic-proctocolitis-single-centre-experience
#8
S B Erdem, H T Nacaroglu, S Karaman, C B Erdur, C U Karkıner, D Can
BACKGROUND: Food protein-induced allergic proctocolitis (FPIAP) is characterised by inflammation of the distal colon in response to one or more food proteins. It is a benign condition of bloody stools in a well-appearing infant, with usual onset between one and four weeks of age. OBJECTIVE: Our objective was to examine the clinical properties of patients with FPIAP, tolerance development time as well as the risk factors that affect tolerance development. METHODS: The clinical symptoms, offending factors, laboratory findings, methods used in the diagnosis and tolerance development for 77 patients followed in the Paediatric Allergy and Gastroenterology Clinics with the diagnosis of FPIAP during January 2010-January 2015 were examined in our retrospective cross-sectional study...
February 1, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28151843/pseudomonas-aeruginosa-associated-diarrheal-diseases-in-children
#9
Chih-Hsien Chuang, Rajendra Prasad Janapatla, Yi-Hsin Wang, Hsin-Ju Chang, Yhu-Chering Huang, Tzou-Yien Lin, Cheng-Hsun Chiu
BACKGROUND: The gastrointestinal tract is not the common infection site of Pseudomonas aeruginosa. The role of P. aeruginosa as a causative agent for diarrhea in children without pre-existing disease is controversial. METHODS: From 2003 to 2012 we reviewed the records of 259 diarrheal patients less than 5 years of age whose stool culture grew P. aeruginosa. Virulence phenotypes of bacterial isolates were determined in vitro, including cytotoxicity, penetration and adherence to epithelial cells...
January 31, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28147377/case-report-acute-flair-of-ulcerative-colitis-during-pregnancy-is-still-a-major-problem
#10
Marijana Protic, Srdjan Markovic, Dino Tarabar
Although severe flare of ulcerative colitis (UC) is uncommon, it significantly increases the risk of preterm delivery, low birth weight and other adverse fetal outcomes. It is critical to optimize aggressive medical treatment with both mother and fetal health. Here, we present a case of a 30-year-old woman with a severe flare of UC at the 16th gestational week. The diagnosis of extensive UC was established 8 years ago. From the time she was diagnosed, she had 5 moderate flares successfully treated with oral and topical mesalamine...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/28147350/late-onset-of-acute-severe-ulcerative-colitis-clinical-case
#11
A E Dorofeyev, O A Rassokhina, A A Dorofeyeva
Ulcerative colitis (UC) in adult age requires more careful examination because more often it turns out to be a complication related to the precancer condition. The onset of colitis in older age is predicted to follow a more aggressive clinical course and requires more frequent hospitalizations and steroids prescription in contrast to its onset in young patients. Even as this remains unclear, we present here a clinical case of late onset of acute severe UC to represent interesting clinical peculiarities and response to the therapy...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/28145162/early-use-of-corticosteroids-in-infants-with-a-clinical-diagnosis-of-pneumocystis-jiroveci-pneumonia-in-malawi-a-double-blind-randomised-clinical-trial
#12
Laura Newberry, Bernadette O'Hare, Neil Kennedy, Andrew Selman, Sofia Omar, Pamela Dawson, Kim Stevenson, Yo Nishihara, Samantha Lissauer, Elizabeth Molyneux
BACKGROUND: Pneumocystis jiroveci pneumonia (PJP) is the most common opportunistic infection in infants with vertically acquired HIV infection and the most common cause of death in HIV-infected infants. OBJECTIVES: To determine whether early administration of adjuvant corticosteroids in addition to standard treatment reduces mortality in infants with vertically acquired HIV and clinically diagnosed PJP when co-infection with cytomegalovirus and other pathogens cannot be excluded...
February 1, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/28143501/safe-and-successful-birth-following-pelvic-radiotherapy-for-rectal-mucosa-associated-lymphoid-tissue-lymphoma-a-case-report
#13
Yoshiomi Hatayama, Masahiko Aoki, Hideo Kawaguchi, Katsumi Hirose, Mariko Sato, Hiroyoshi Akimoto, Mitsuki Tanaka, Ichitaro Fujioka, Shuichi Ono, Yoshihiro Takai
BACKGROUND: Mucosa-associated lymphoid tissue lymphomas can occur in various parts of the body, and half of mucosa-associated lymphoid tissue lymphomas occur in the gastrointestinal tract. Gastric mucosa-associated lymphoid tissue lymphoma is the most common lymphoma of the gastrointestinal tract and primary rectal mucosa-associated lymphoid tissue lymphoma is very rare. Because of the high radiosensitivity of mucosa-associated lymphoid tissue lymphomas, this condition can be controlled with radiotherapy of approximately 30 Gy alone...
February 1, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28138447/diarrhea-concealing-a-duodenal-cecal-fistula-secondary-to-appendiceal-mucinous-neoplasm
#14
Su Aung, Amanda Cheung, Charlene Prather, Jinping Lai
Primary mucinous adenocarcinoma of the appendix is a rare gastrointestinal malignancy. Fistulous tract formation is a complication that is cited in literature. An 85-year-old man with multiple comorbidities presented with several weeks of persistent non-bloody diarrhea. Laboratory work-up was non-diagnostic. Abdominal imaging with barium contrast showed an enterocolonic fistulous tract extending from the duodenum to the cecum involving an enlarged appendiceal mass. Subsequent biopsy confirmed mucinous appendiceal neoplasm with peritoneal spread to the liver and mesentery...
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28137903/subcorneal-pustular-dermatosis-and-episcleritis-associated-with-poorly-controlled-ulcerative-colitis
#15
Jeffrey J Wargo, Megan Adams, Julian Trevino
A man aged 56 years with a history of ulcerative colitis (UC) status postsubtotal colectomy was hospitalised with fevers, dry cough, eye redness and a new bloody, mucoid rectal discharge. 2 months prior to admission, the dermatologist had started him on dapsone for subcorneal pustular dermatosis but did not recognise that he had recently self-discontinued mesalamine enemas, inducing a flare of his UC. After a thorough inpatient evaluation, including flexible sigmoidoscopy, active UC involving the rectal stump was determined to be driving his dermatological and ophthalmological findings...
January 30, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28137731/clinical-presentation-autopsy-results-and-toxicology-findings-in-an-acute-n-ethylpentylone-fatality
#16
Phoutthasone Thirakul, Laura S Hair, Kirstin L Bergen, Julia M Pearson
The clinical presentation, autopsy findings and toxicology results in an acute fatality involving N-ethylpentylone, a new cathinone derivative, are described. Law enforcement transported a male who was agitated and exhibiting unusual behavior to a local hospital. Upon arrival at the hospital, his body temperature was 105.5 degrees Fahrenheit and his blood pH was 6.7. Clinical laboratory analysis revealed elevated troponins, rhabdomyolysis, hypoglycemia, hepatic and renal injury, respiratory failure and disseminated intravascular coagulation...
January 30, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28133308/-a-case-of-laparoscopic-surgery-for-rectal-cancer-with-synchronous-lung-metastases-after-chemotherapy
#17
Tatsuya Yoshida, Hajime Morohashi, Daichi Ichinohe, Eri Yoshida, Kensuke Okano, Hayato Nagase, Harue Akasaka, Hiroyuki Jin, Takuya Miura, Yoshiyuki Sakamoto, Kenichi Hakamada
A woman in her 70's presented with the predominant complaint of bloody stools. She was diagnosed with rectal cancer, and bilateral lymph node and pulmonary metastases were detected on computed tomography(CT). The patient was diagnosed with cT3N3M1a, cStage IV disease. After undergoing a colostomy, the patient was treated with S-1 plus oxaliplatin (SOX), and bevacizumab(Bev). A second CT scan obtained after completion of 7 courses of chemotherapy revealed that the lung metastases had significantly reduced or disappeared...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133306/-effectiveness-of-irinotecan-s-1-and-bevacizumab-for-rectal-cancer-with-lung-and-skin-metastases-after-adjuvant-chemotherapy
#18
Kiyotaka Hagihara, Masataka Ikeda, Sakae Maeda, Mamoru Uemura, Kazuyoshi Yamamoto, Masakazu Miyake, Naoki Hama, Kazuhiro Nishikawa, Atsushi Miyamoto, Hideyasu Omiya, Michihiko Miyazaki, Motohiro Hirao, Koji Takami, Shoji Nakamori, Mitsugu Sekimoto
A 50-year-old woman with a chief complaint of bloody stools was diagnosed with rectal cancer via colonoscopy. Laparoscopic rectal anterior resection with D3 lymph node dissection was performed in June 2014. The pathological diagnosis was pStage III a(Ra, pT3, N1)cancer, and the patient received 8 courses of XELOX as postoperative adjuvant chemotherapy. During follow-up at 12 months after surgery, chest computed tomography revealed a mass in the left lingular segment measuring 25mm in diameter and multiple small nodules in both the lungs, indicating lung metastases...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133295/-a-systematic-analysis-of-oncogene-and-tumor-suppressor-genes-for-panitumumab-resistant-rectal-cancer-with-wild-ras-gene-a-case-report
#19
Yosuke Tajima, Yoshifumi Shimada, Ryoma Yagi, Takuma Okamura, Masato Nakano, Hitoshi Kameyama, Hitoshi Nogami, Satoshi Maruyama, Yasumasa Takii, Kohei Miura, Hiroshi Ichikawa, Masayuki Nagahashi, Jun Sakata, Takashi Kobayashi, Toshifumi Wakai
A 58-year-old man was admitted with the complaint of bloody stools. Colonoscopy and computed tomography revealed a rectal cancer with a liver metastasis and multiple lung metastases. After administering a regimen comprising 3 courses of XELOX plus bevacizumab chemotherapy, the sizes of the primary and metastatic lesions decreased remarkably. Abdominoperineal resection was performed for local control of the cancer; the specimen from the initial tumor was found to be KRAS wild type. After 14 courses of XELOX chemotherapy, brain metastases were detected...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133257/-a-case-of-intussusception-caused-by-descending-colon-cancer
#20
Shinnosuke Hotta, Hitoshi Kameyama, Kenji Sato, Manabu Oyamatsu, Yoshifumi Hashimoto, Yu Sato, Takawa Iwaki, Yoshifumi Shimada, Jun Sakata, Takashi Kobayashi, Toshifumi Wakai
A46 -year-old male presented with bloody stool and a descending colon tumor, as identified using colon fiberscopy. The patient did not complain of any remarkable abdominal symptoms. Computed tomography revealed descending colon tumor intussusception. We performed partial resection of the descending colon and D2 lymphadenectomy without intraoperative reduction. The descending colon was barely attached to the retroperitoneum and was mobile. The underlying tumor was type 1 and measured 8.3×5.8 cm. The pathology report indicated a mucinous adenocarcinoma with extension through the submucosa into the subserosa, and metastasis in 6 nearby lymph nodes(n2)...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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