keyword
https://read.qxmd.com/read/38547511/operating-properties-of-disease-activity-indices-in-pediatric-inflammatory-bowel-disease-a-systematic-review
#1
JOURNAL ARTICLE
Ruben J Colman, Virginia Solitano, John K MacDonald, Christopher Ma, Anne M Griffiths, Vipul Jairath, Eileen Crowley
BACKGROUND: Accurate, reliable, and responsive disease activity indices are important to streamline drug approval and treatment modalities for pediatric inflammatory bowel disease (pIBD). We aimed to identify all scoring indices used in pIBD randomized controlled trials (RCTs) and to evaluate their operating properties. METHODS: MEDLINE, EMBASE, and CENTRAL were searched on December 6, 2022, to identify studies evaluating clinical, endoscopic, imaging, or patient-reported outcome measures (PROMs) in pIBD including Crohn's disease (CD) and ulcerative colitis (UC)...
March 28, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38547483/benefits-and-challenges-of-implementing-an-adaptation-of-family-integrated-care-in-a-ugandan-setting
#2
JOURNAL ARTICLE
Nancy Feeley, Olive Kabajaasi, Nathan Kenya-Mugisha, Abner Tagoola, Karel O'Brien, Jessica Duby
BACKGROUND: Family Integrated Care (FICare) integrates parents as partners in neonatal intensive care unit care. Our team adapted and implemented this approach in a Ugandan unit for hospitalized neonates. PURPOSE: This qualitative descriptive study examined the perceptions of mothers and healthcare professionals (HCPs) of the benefits and challenges of this new approach to care. METHODS: Fifty-one mothers of hospitalized neonates born weighing greater than 2000 g participated in the program...
April 1, 2024: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://read.qxmd.com/read/38547447/association-of-biomarkers-of-neuronal-injury-and-inflammation-with-insomnia-trajectories-after-traumatic-brain-injury-a-track-tbi-study
#3
JOURNAL ARTICLE
J Kent Werner, Jennifer Albrecht, Vincent F Capaldi, Sonia Jain, Xiaoying Sun, Pratik Mukherjee, Scott G Williams, Jacob Collen, Ramon Diaz-Arrastia, Geoffrey T Manley, Andrew D Krystal, Emerson Wickwire
BACKGROUND AND OBJECTIVES: Insomnia affects about one-third of patients with traumatic brain injury and is associated with worsened outcomes after injury. We hypothesized that higher levels of plasma neuroinflammation biomarkers at the time of TBI would be associated with worse 12-month insomnia trajectories. METHODS: Participants were prospectively enrolled from 18 level-1 trauma centers participating in the Transforming Research and Clinical Knowledge in Traumatic Brain Injury study from February 26, 2014, to August 8, 2018...
April 23, 2024: Neurology
https://read.qxmd.com/read/38547432/true-confessions-of-neutral-mechanical-disciple-how-i-learned-to-love-a-patient-specific-target
#4
JOURNAL ARTICLE
Nathalie Willems, Kevin B Marchand, Christina Esposito, Daniele De Massari, Daniel Hameed, Gavin Clark, Robert Marchand, Michael A Mont, Michael Dunbar
INTRODUCTION: Classical neutral mechanical alignment in total knee arthroplasty (TKA) has been a standard paradigm, while more recently, other alignment schemas, such as kinematic, individualized, and functional, have been explored. This study aimed to investigate the effect of three-dimensional (3D) computed tomography (CT)-based surgical robotics inputs on a classically trained surgeon's TKA component positions and alignment targets over time. MATERIALS AND METHODS: Data from 1,394 consecutive robotically-assisted TKAs by a single surgeon from 2016 to 2020 were analyzed...
March 7, 2024: Surgical Technology International
https://read.qxmd.com/read/38547418/human-epidermal-growth-factor-receptor-2-low-breast-cancer-brain-metastases-an-opportunity-for-targeted-systemic-therapies-in-a-high-need-patient-population
#5
JOURNAL ARTICLE
Rania Chehade, Sharon Nofech-Mozes, Anna Plotkin, Kevin Yijun Fan, Sunit Das, Arjun Sahgal, Veronika Moravan, Katarzyna Joanna Jerzak
PURPOSE: Trastuzumab deruxtecan is a new treatment option for patients with advanced human epidermal growth factor receptor 2 (HER2)-low breast cancer (BC). Although HER2-low status has been characterized in early and advanced BC, it has yet to be fully characterized in brain metastases (BrM). METHODS: Patients who underwent surgery for BC BrM at Sunnybrook Health Sciences Centre and for whom HER2 status was available on resected BrM were studied. Estrogen receptor, progesterone receptor, and HER2 status were assessed on the basis of ASCO/College of American Pathologists (CAP) guidelines...
March 2024: JCO Precision Oncology
https://read.qxmd.com/read/38547411/perspectives-in-precautionary-allergen-labelling-of-prepackaged-foods-after-the-fao-who-consultation
#6
JOURNAL ARTICLE
Vincenzo Fierro, Carmen Mazzuca, Sara Urbani, Lamia Dahdah, Veronica Calandrelli, Rocco Luigi Valluzzi, Dinardo Giulio
PURPOSE OF REVIEW: The purpose of this review is to provide an overview of the perspectives regarding precautionary allergen labelling (PAL) of prepackaged foods following the consultation conducted by the Food and Agriculture Organization (FAO) and the WHO. RECENT FINDINGS: The FAO/WHO consultation provided a comprehensive assessment of the current status and practices of PAL implementation worldwide. One of the key findings highlighted by the Expert Committee was the need for improvement in existing PAL systems...
March 29, 2024: Current Opinion in Allergy and Clinical Immunology
https://read.qxmd.com/read/38547408/oesophageal-fluoroscopy-when-and-why
#7
JOURNAL ARTICLE
Martina Scharitzer, Peter Pokieser, Olle Ekberg
Oesophageal fluoroscopy is a radiological procedure that uses dynamic recording of the swallowing process to evaluate morphology and function simultaneously, a characteristic not found in other clinical tests. It enables a comprehensive evaluation of the entire upper gastrointestinal tract, from the oropharynx to oesophagogastric bolus transport. The number of fluoroscopies of the oesophagus and the oropharynx has increased in recent decades, while the overall use of gastrointestinal fluoroscopic examinations has declined...
March 28, 2024: British Journal of Radiology
https://read.qxmd.com/read/38547390/pluripotent-stem-cells-for-target-organ-developmental-toxicity-testing
#8
JOURNAL ARTICLE
Xian Wu, Yichang Chen, Anna Kreutz, Brian Silver, Erik J Tokar
Prenatal developmental toxicity research focuses on understanding potential adverse effects of environmental agents, drugs, and chemicals on the development of embryos and fetuses. Traditional methods involve animal testing, but ethical concerns and the need for human-relevant models have prompted the exploration of alternatives. Pluripotent stem cells (PSCs) are versatile cells with the unique ability to differentiate into any cell type, serving as a foundational tool for studying human development. Two-dimensional (2D) PSC models are often chosen for their ease of use and reproducibility for high-throughput screening...
March 28, 2024: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/38547365/sustainable-equipment-donation-in-otolaryngology-in-low-resource-settings
#9
JOURNAL ARTICLE
Catherine de Cates, Aurélien M Guéroult, Gan-Erdene Narantsolmon
PURPOSE OF REVIEW: The purpose of this review is to examine current practices in surgical equipment donation to lower- and middle-income countries (LMICs) with a particular focus on otolaryngology-head and neck surgery (OHNS). This is designed as a pragmatic review to guide potential donor communities to implement sustainable OHNS equipment donation in LMICs. RECENT FINDINGS: LMICs are increasingly reliant on international equipment donation. In terms of OHNS services, global OHNS have compiled a list of essential equipment for baseline care in LMICs...
March 19, 2024: Current Opinion in Otolaryngology & Head and Neck Surgery
https://read.qxmd.com/read/38547351/an-evaluation-of-mental-health-integration-in-the-neglected-tropical-diseases-program-in-zamfara-north-west-nigeria
#10
JOURNAL ARTICLE
Sunday Udo, Pius Sunday Ogbu, Paul A Tsaku, Aliyu Tukur, Andrew NewMarch
BACKGROUND: Mental health and neglected tropical diseases (NTDs) are critical in healthcare systems, especially in low- and middle-income countries. Several policies are planned or designed by health stakeholders to address the mental health needs of people affected by NTDs. Still, the impact of such policies seems to be of no consequence. METHODS: The GAD-7 and PHQ-9 tools were used to determine the rate of depression and anxiety, respectively, among people affected by skin NTDs (leprosy and lymphatic filariasis [LF]) in Zamfara State, North-west Nigeria...
March 28, 2024: International Health
https://read.qxmd.com/read/38547350/a-pilot-study-to-address-the-mental-health-of-persons-living-with-lymphatic-filariasis-in-l%C3%A3-og%C3%A3-ne-haiti-implementing-a-chronic-disease-self-management-program-using-a-stepped-wedge-cluster-design
#11
JOURNAL ARTICLE
Shanze Sadiq, Karen E S Hamre, Samhita Kumar, Sarah Bazur-Leidy, Luccène Désir, M Martha Désir, Murielle C Gilbert, V Madsen Beau de Rochars, Marc-Aurèle Telfort, Gregory S Noland, Eve Byrd
BACKGROUND: Neglected tropical diseases (NTDs) inflict significant comorbid disability on the most vulnerable communities; yet interventions targeting the mental health of affected communities are lacking. A pilot study to assess the effectiveness of a chronic disease self-management program (CDSMP) was introduced to lymphatic filariasis peer support groups in Léogâne, Haiti. METHODS: Using a closed-cohort stepped-wedge cluster trial design, Hope Clubs were assigned into Arm 1 (n=118 members) and Arm 2 (n=92)...
March 28, 2024: International Health
https://read.qxmd.com/read/38547335/impact-of-iodine-supply-in-infancy-and-childhood
#12
JOURNAL ARTICLE
Dominique Turck
PURPOSE OF REVIEW: To assess the most relevant articles on the impact of iodine supply in at-risk populations, namely infants and young children, pregnant and lactating women. RECENT FINDINGS: The 2022 Iodine Global Network Annual Report confirmed the dramatic decrease of severe iodine deficiency over the last 30 years, thanks to universal iodine iodization. However, mild to moderate deficiency is still present in many countries, where recent data showed a decrease of iodine intake and an impairment of iodine status...
March 28, 2024: Current Opinion in Clinical Nutrition and Metabolic Care
https://read.qxmd.com/read/38547300/a-pilot-randomised-controlled-trial-comparing-the-effectiveness-of-the-materre180-participatory-tool-including-a-serious-game-versus-an-intervention-including-carbon-footprint-awareness-raising-on-behaviours-among-academia-members-in-france
#13
JOURNAL ARTICLE
Claudia Teran-Escobar, Nicolas Becu, Nicolas Champollion, Nicolas Gratiot, Benoît Hingray, Gérémy Panthou, Isabelle Ruin
BACKGROUND: Activities embedded in academic culture (international conferences, field missions) are an important source of greenhouse gas emissions. For this reason, collective efforts are still needed to lower the carbon footprint of Academia. Serious games are often used to promote ecological transition. Nevertheless, most evaluations of their effects focus on changes in knowledge and not on behaviour. The main objectives of this study are to 1) Evaluate the feasibility of a control and an experimental behaviour change intervention and, 2) Evaluate the fidelity (the extent to which the implementation of the study corresponds to the original design) of both interventions...
2024: PloS One
https://read.qxmd.com/read/38547284/quantifying-methane-emissions-from-united-states-landfills
#14
JOURNAL ARTICLE
Daniel H Cusworth, Riley M Duren, Alana K Ayasse, Ralph Jiorle, Katherine Howell, Andrew Aubrey, Robert O Green, Michael L Eastwood, John W Chapman, Andrew K Thorpe, Joseph Heckler, Gregory P Asner, Mackenzie L Smith, Eben Thoma, Max J Krause, Daniel Heins, Susan Thorneloe
Methane emissions from solid waste may represent a substantial fraction of the global anthropogenic budget, but few comprehensive studies exist to assess inventory assumptions. We quantified emissions at hundreds of large landfills across 18 states in the United States between 2016 and 2022 using airborne imaging spectrometers. Spanning 20% of open United States landfills, this represents the most systematic measurement-based study of methane point sources of the waste sector. We detected significant point source emissions at a majority (52%) of these sites, many with emissions persisting over multiple revisits (weeks to years)...
March 29, 2024: Science
https://read.qxmd.com/read/38547235/covid-19-vaccine-uptake-and-barriers-among-indigenous-language-speakers-in-mexico-results-from-a-nationally-representative-survey
#15
JOURNAL ARTICLE
Lucía Abascal Miguel, Cesar A Mendez-Lizarraga, Elizabeth M Rojo, Jaime Sepúlveda
Mexico faced a significant burden from the COVID-19 pandemic. Since the pandemic's onset in 2020, numerous studies have underscored the substantial risk of COVID-19 death among Indigenous individuals. This study aims to assess COVID-19 vaccine uptake among Indigenous language speakers in Mexico, focusing on understanding the barriers they face in obtaining access to vaccines. We used Encuesta Nacional de Salud y Nutrición Continua (ENSANUT) 2022, a nationally representative health survey in Mexico to analyze data on self-reported COVID-19 vaccine status, reasons for not getting vaccinated, and other relevant covariates...
2024: PLOS Glob Public Health
https://read.qxmd.com/read/38547211/short-term-chemotherapy-related-complications-and-undernutrition-in-children-diagnosed-with-cancer-at-korle-bu-teaching-hospital-accra-ghana-a-prospective-cohort-study
#16
JOURNAL ARTICLE
Nihad Salifu, Catherine I Segbefia, Yakubu Alhassan, Lorna A Renner, Edem M A Tette
Undernutrition in children with cancer is associated with complications during cancer therapy. The study objective was to determine the association between specific anthropometric parameters and short-term chemotherapy-related complications and mortality. This was a hospital-based, prospective cohort study of children, age ≤12 years, with a new cancer diagnosis at the Paediatric Oncology Unit, Korle Bu Teaching Hospital, Ghana. Socio-demographic information, cancer characteristics and anthropometric measurements were obtained at enrolment...
2024: PloS One
https://read.qxmd.com/read/38547199/prognostic-accuracy-of-early-warning-scores-for-predicting-serious-illness-and-in-hospital-mortality-in-patients-with-covid-19
#17
JOURNAL ARTICLE
Mehnaz Kamal, S M Tafsir Hasan, Monira Sarmin, Subhasish Das, Lubaba Shahrin, A S G Faruque, Mohammod Jobayer Chisti, Tahmeed Ahmed
A simple bedside triage tool is essential to stratify COVID-19 patients in the emergency department (ED). This study aimed to identify an early warning score (EWS) that could best predict the clinical outcomes in COVID-19 patients. Data were obtained from medical records of 219 laboratory-confirmed COVID-19 positive patients. We calculated 13 EWSs based on the admission characteristics of the patients. Receiver operating characteristic (ROC) curve analysis was used to assess the performance of the scores in predicting serious illness and in-hospital mortality...
2024: PLOS Glob Public Health
https://read.qxmd.com/read/38547170/attitude-and-predictors-of-exclusive-breastfeeding-practice-among-mothers-attending-under-five-welfare-clinics-in-a-rural-community-in-southwestern-nigeria
#18
JOURNAL ARTICLE
Tope Michael Ipinnimo, Olanrewaju Kassim Olasehinde, Taofeek Adedayo Sanni, Ayodeji Andrew Omotoso, Rita Omobosola Alabi, Paul Oladapo Ajayi, Kayode Rasaq Adewoye, John Olujide Ojo, Olayinka Oloruntoba, Ademuyiwa Adetona, Mojoyinola Oyindamola Adeosun, Temitope Moronkeji Olanrewaju, Oluseyi Adedeji Aderinwale, Blessing Omobolanle Osho, Adewumi Rufus Fajugbagbe, Precious Aderinsola Adeyeye, Ayotomiwa Fiyinfoluwa Ajayi
BACKGROUND: Much previous research on exclusive breastfeeding has focused on urban and semi-urban communities, while there is still a paucity of data from rural areas. We assessed the attitude and practice of exclusive breastfeeding and its predictors among mothers attending the under-five welfare clinics in a rural community. METHODS: A cross-sectional study was conducted among consecutively recruited 217 mothers attending the three health facilities under-five welfare clinics in Ido-Ekiti, Southwest, Nigeria...
2024: PloS One
https://read.qxmd.com/read/38547144/enhancing-rural-b-b-management-through-machine-learning-and-evolutionary-game-a-case-study-of-rural-revitalization-in-yunnan-china
#19
JOURNAL ARTICLE
Wiseong Jin, Kwisik Min, Xufang Hu, Shengchao Li, Xueqin Wang, Bodong Song, Chengmeng Li
The rural B&B industry is a key component of rural tourism, local economic development, and the wider rural revitalization strategy. Despite the abundance of tourism resources in Yunnan, the B&B sector faces significant challenges. It is therefore imperative to accurately identify the most pressing issues within the current B&B industry and formulate appropriate solutions to advance Yunnan's rural revitalization efforts. This study uses recent reviews of rural B&Bs on Ctrip.com and employs machine learning techniques, including Bert, CNN, LSTM, and GRU, to identify the key management challenges currently facing Yunnan's rural B&B industry...
2024: PloS One
https://read.qxmd.com/read/38547141/human-animal-entanglements-in-bushmeat-trading-in-sierra-leone-an-ethnographic-assessment-of-a-potential-zoonotic-interface
#20
JOURNAL ARTICLE
Jack Jenkins, Wahab Lawundeh, Tommy Hanson, Hannah Brown
'Bushmeat' markets are often portrayed as chaotic spaces where exotic wild animals are sold. They are hypothesized to be important sites for zoonotic disease transmission, given the prolonged and intense nature of the cross-species encounters that occur within them. Whilst such markets have received some attention from researchers, rich qualitative descriptions of everyday practices in these markets are rare. Depictions of wild animal markets as sites for potential viral amplification often rely on exoticizing assumptions and narratives rather than actual evidence, and in some cases are based more on ideology than on science...
2024: PloS One
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