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https://www.readbyqxmd.com/read/28820527/spatiotemporal-hydrogel-biomaterials-for-regenerative-medicine
#1
REVIEW
Tobin E Brown, Kristi S Anseth
Hydrogels mimic many of the physical properties of soft tissue and are widely used biomaterials for tissue engineering and regenerative medicine. Synthetic hydrogels have been developed to recapitulate many of the healthy and diseased states of native tissues and can be used as a cell scaffold to study the effect of matricellular interactions in vitro. However, these matrices often fail to capture the dynamic and heterogenous nature of the in vivo environment, which varies spatially and during events such as development and disease...
August 18, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28814702/reorganizing-hospital-space-the-1894-plague-epidemic-in-hong-kong-and-the-germ-theory
#2
Kyu-Hwan Sihn
This paper examined whether the preventive measures taken by the Hong Kong's colonial authorities were legitimate during the 1894 Hong Kong plague epidemic, and illuminated the correlation between the plague epidemic and hospital space in Hong Kong in the late 19th century. The quarantine measures taken by the colonial authorities were neither a clear-cut victory for Western medicine nor for a rational quarantine based on scientific medical knowledge. Hong Kong's medical officials based on the miasma theory, and focused only on house-to-house inspections and forced quarantine or isolation, without encouraging people to wear masks and without conducting disinfection...
April 2017: Ŭi Sahak
https://www.readbyqxmd.com/read/28812819/advancing-public-health-on-the-changing-global-trade-and-investment-agenda-comment-on-the-trans-pacific-partnership-is-it-everything-we-feared-for-health
#3
Anne Marie Thow, Deborah Gleeson
Concerns regarding the Trans-Pacific Partnership (TPP) have raised awareness about the negative public health impacts of trade and investment agreements. In the past decade, we have learned much about the implications of trade agreements for public health: reduced equity in access to health services; increased flows of unhealthy commodities; limits on access to medicines; and constrained policy space for health. Getting health on the trade agenda continues to prove challenging, despite some progress in moving towards policy coherence...
September 28, 2016: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28812309/murine-pulmonary-imaging-at-7t-t2-and-t1-with-anisotropic-ute
#4
Jinbang Guo, Xuefeng Cao, Zackary I Cleveland, Jason C Woods
PURPOSE: To measure the T2* and T1 of mouse lung at 7T via anisotropic-resolution radial ultrashort echo-time imaging with ellipsoidal k-space coverage. METHODS: Ellipsoidal field-of-view was created by expanding uniform spherical k-space coverage. The effects of T2* and ellipsoidal sampling on image resolution were investigated by using point-spread-function analysis and resolution phantoms. Finally, this ellipsoidal sampling approach was used to measure the lung T2* and T1 of healthy C57BL/6 mice at the increasingly common preclinical field strength of 7T...
August 15, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28811100/is-supercritical-fluid-chromatography-hyphenated-to-mass-spectrometry-suitable-for-the-quality-control-of-vitamin-d3-oily-formulations
#5
B Andri, A Dispas, R Klinkenberg, B Streel, R D Marini, E Ziémons, Ph Hubert
Nowadays, many efforts are devoted to improve analytical methods regarding efficiency, analysis time and greenness. In this context, Supercritical Fluid Chromatography (SFC) is often regarded as a good alternative over Normal Phase Liquid Chromatography (NPLC). Indeed, modern SFC separations are fast, efficient with suitable quantitative performances. Moreover, the hyphenation of SFC to mass spectrometry (MS) provides additional gains in specificity and sensitivity. The present work aims at the determination of vitamin D3 by SFC-MS for routine Quality Control (QC) of medicines specifically...
July 27, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28804918/low-rank-approximation-methods-for-mr-fingerprinting-with-large-scale-dictionaries
#6
Mingrui Yang, Dan Ma, Yun Jiang, Jesse Hamilton, Nicole Seiberlich, Mark A Griswold, Debra McGivney
PURPOSE: This work proposes new low rank approximation approaches with significant memory savings for large scale MR fingerprinting (MRF) problems. THEORY AND METHODS: We introduce a compressed MRF with randomized singular value decomposition method to significantly reduce the memory requirement for calculating a low rank approximation of large sized MRF dictionaries. We further relax this requirement by exploiting the structures of MRF dictionaries in the randomized singular value decomposition space and fitting them to low-degree polynomials to generate high resolution MRF parameter maps...
August 13, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28801135/pyrrolo-2-1-f-1-2-4-triazines-from-c-nucleosides-to-kinases-and-back-again-the-remarkable-journey-of-a-versatile-nitrogen-heterocycle
#7
REVIEW
Gregory R Ott, David A Favor
Pyrrolo[2,1-f][1,2,4]triazine, a unique NN bond-containing heterocycle with a bridgehead nitrogen, was first synthesized in the late 1970s but did not find utility until more than a decade later in the early 1990s when it was incorporated into C-nucleosides as a novel purine-like mimetic. This heterocycle remained at the fringes of medicinal chemistry until a confluence of events spurred by the explosion of the kinase inhibitor field in the early 2000s and the pressing need for novel, druggable scaffolds to occupy that exciting space led to numerous applications against diverse therapeutic targets...
July 30, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28796716/an-intensive-simulation-based-communication-course-for-pediatric-critical-care-medicine-fellows
#8
Erin M Johnson, Melinda F Hamilton, R Scott Watson, Rene Claxton, Michael Barnett, Ann E Thompson, Robert Arnold
OBJECTIVE: Effective communication among providers, families, and patients is essential in critical care but is often inadequate in the PICU. To address the lack of communication education pediatric critical care medicine fellows receive, the Children's Hospital of Pittsburgh PICU developed a simulation-based communication course, Pediatric Critical Care Communication course. Pediatric critical care medicine trainees have limited prior training in communication and will have increased confidence in their communication skills after participating in the Pediatric Critical Care Communication course...
August 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28795460/how-do-people-conceptualise-the-reuse-of-medicines-an-interview-study
#9
Hamza Alhamad, Nilesh Patel, Parastou Donyai
OBJECTIVES: To capture people's beliefs about medicines reuse and to map the determinants of intentions to reuse medicines in the future. METHODS: Participants were recruited through an advert placed in the university's community newsletter reaching 15 000 households. Adults wishing to participate were interviewed using convenience sampling, with recruitment continuing until data saturation. Participants were interviewed face-to-face by two researchers using a semi-structured interview schedule based on the theory of planned behaviour (TPB)...
August 9, 2017: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28795419/simultaneous-mr-thermometry-and-acoustic-radiation-force-imaging-using-interleaved-acquisition
#10
Joshua T de Bever, Henrik Odéen, Lorne W Hofstetter, Dennis L Parker
PURPOSE: A novel and practical method for simultaneously performing MR acoustic radiation force imaging (ARFI) and proton resonance frequency (PRF)-shift thermometry has been developed and tested. This could be an important tool for evaluating the success of MR-guided focused ultrasound procedures for which MR-thermometry measures temperature and thermal dose and MR-ARFI detects changes in tissue mechanical properties. METHODS: MR imaging was performed using a gradient recalled echo segmented echo-planar imaging pulse sequence with bipolar motion encoding gradients (MEG)...
August 10, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28792683/mechanotransduction-and-growth-factor-signalling-to-engineer-cellular-microenvironments
#11
REVIEW
Amaia Cipitria, Manuel Salmeron-Sanchez
Engineering cellular microenvironments involves biochemical factors, the extracellular matrix (ECM) and the interaction with neighbouring cells. This progress report provides a critical overview of key studies that incorporate growth factor (GF) signalling and mechanotransduction into the design of advanced microenvironments. Materials systems have been developed for surface-bound presentation of GFs, either covalently tethered or sequestered through physico-chemical affinity to the matrix, as an alternative to soluble GFs...
August 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28791441/postoperative-pain-control-by-intercostal-nerve-block-after-augmentation-mammoplasty
#12
Chang Min Kang, Woo Jeong Kim, Sean Hyuck Yoon, Chul Bum Cho, Jeong Su Shim
BACKGROUND: In breast augmentation with implant, there is severe pain due to damage from expansion of breast tissue and the pectoralis major. Therefore, the authors conducted this study to analyze the effectiveness of postoperative intercostal nerve block (ICNB) in reducing postoperative pain after breast augmentation with implant. METHOD: Forty-four female patients were enrolled in the study. Just before awaking from general anesthesia, 34 cases were injected with 0...
August 8, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28782129/volumetric-mri-thermometry-using-a-three-dimensional-stack-of-stars-echo-planar-imaging-pulse-sequence
#13
Sumeeth V Jonathan, William A Grissom
PURPOSE: To measure temperature over a large brain volume with fine spatiotemporal resolution. METHODS: A three-dimensional stack-of-stars echo-planar imaging sequence combining echo-planar imaging and radial sampling with golden angle spacing was implemented at 3T for proton resonance frequency-shift temperature imaging. The sequence acquires a 188x188x43 image matrix with 1.5x1.5x2.75 mm(3) spatial resolution. Temperature maps were reconstructed using sensitivity encoding (SENSE) image reconstruction followed by the image domain hybrid method, and using the k-space hybrid method...
August 7, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28776416/synthetic-agonists-of-nod-like-rig-i-like-and-c-type-lectin-receptors-for-probing-the-inflammatory-immune-response
#14
Amy E Nielsen, Joseph D Hantho, Rock J Mancini
Synthetic agonists of innate immune cells are of interest to immunologists due to their synthesis from well-defined materials, optimized activity, and monodisperse chemical purity. These molecules are used in both prophylactic and therapeutic contexts from vaccines to cancer immunotherapies. In this review we highlight synthetic agonists that activate innate immune cells through three classes of pattern recognition receptors: NOD-like receptors, RIG-I-like receptors, and C-type lectin receptors. We classify these agonists by the receptor they activate and present them from a chemical perspective, focusing on structural components that define agonist activity...
August 4, 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/28771867/motion-corrected-k-space-reconstruction-for-interleaved-epi-diffusion-imaging
#15
Zijing Dong, Fuyixue Wang, Xiaodong Ma, Erpeng Dai, Zhe Zhang, Hua Guo
PURPOSE: To develop a new approach to correct for physiological and macroscopic motion in multishot, interleaved echo-planar diffusion imaging. THEORY: This work built on the previous SPIRiT (iterative self-consistent parallel imaging reconstruction) based reconstruction for physiological motion correction in multishot diffusion-weighted imaging to account for macroscopic motion. In-plane rotation, translation correction, data rejection, and weighted combination are integrated in SPIRiT-based reconstruction to correct for ghosting artifacts, blurring, altered b-matrix, and residual artifacts caused by motion...
August 3, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28759585/today%C3%A2-s-medical-self-and-the-other-challenges-and-evolving-solutions-for-enhanced-humanization-and-quality-of-care
#16
Perla Sueiras, Victoria Romano-Betech, Alejandro Vergil-Salgado, Adalberto de Hoyos, Silvia Quintana-Vargas, William Ruddick, Anaclara Castro-Santana, Sergio Islas-Andrade, Nelly F Altamirano-Bustamante, Myriam M Altamirano-Bustamante
BACKGROUND: Recent scientific developments, along with growing awareness of cultural and social diversity, have led to a continuously growing range of available treatment options; however, such developments occasionally lead to an undesirable imbalance between science, technology and humanism in clinical practice. This study explores the understanding and practice of values and value clusters in real-life clinical settings, as well as their role in the humanization of medicine and its institutions...
2017: PloS One
https://www.readbyqxmd.com/read/28752817/selection-and-transmission-of-antibiotic-resistant-bacteria
#17
Dan I Andersson, Diarmaid Hughes
Ever since antibiotics were introduced into human and veterinary medicine to treat and prevent bacterial infections there has been a steady selection and increase in the frequency of antibiotic resistant bacteria. To be able to reduce the rate of resistance evolution, we need to understand how various biotic and abiotic factors interact to drive the complex processes of resistance emergence and transmission. We describe several of the fundamental factors that underlay resistance evolution, including rates and niches of emergence and persistence of resistant bacteria, time- and space-gradients of various selective agents, and rates and routes of transmission of resistant bacteria between humans, animals and other environments...
July 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28748713/qbd-for-pediatric-oral-lyophilisates-development-risk-assessment-followed-by-screening-and-optimization
#18
Tibor Casian, Sonia Iurian, Catalina Bogdan, Lucia Rus, Mirela Moldovan, Ioan Tomuta
OBJECTIVE: This study proposed the development of oral lyophilisates with respect to pediatric medicine development guidelines, by applying risk management strategies and DoE as an integrated QbD approach. METHODS: Product critical quality attributes were overviewed by generating Ishikawa diagrams for risk assessment purposes, considering process, formulation and methodology related parameters. Failure Mode Effect Analysis was applied to highlight critical formulation and process parameters with an increased probability of occurrence and with a high impact on the product performance...
August 16, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28744321/an-18-f-positron-emitting-fluorescent-cerebrospinal-fluid-probe-for-imaging-damage-to-the-brain-and-spine
#19
Harikrishna Kommidi, Hua Guo, Nandi Chen, Dohyun Kim, Bin He, Amy P Wu, Omer Aras, Richard Ting
Fluorescein is modified to bear (18)F so that it can act as both a positron emitter, and a fluorophore, allowing detection by positron emission tomography (PET), scintillation, and fluorescent imaging (FL). [(18)F]-2 is injected into the intrathecal space of rats and used to observe the cerebrospinal fluid (CSF) that bathes the brain and spine. Injury in three different applications is visualized with [(18)F]-2: 1) detection of a 0.7 mm paranasal-sinus CSF leak (CSFL); 2) detection of 0.5 mm puncture damage to the thoracic spine (acute spinal cord injury); and 3) detection of intracerebral hemorrhage/edema because of traumatic brain injury...
2017: Theranostics
https://www.readbyqxmd.com/read/28744188/circadian-metabolomics-in-time-and-space
#20
REVIEW
Kenneth A Dyar, Kristin L Eckel-Mahan
Circadian rhythms are widely known to govern human health and disease, but specific pathogenic mechanisms linking circadian disruption to metabolic diseases are just beginning to come to light. This is thanks in part to the development and application of various "omics"-based tools in biology and medicine. Current high-throughput technologies allow for the simultaneous monitoring of multiple dynamic cellular events over time, ranging from gene expression to metabolite abundance and sub-cellular localization...
2017: Frontiers in Neuroscience
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