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https://www.readbyqxmd.com/read/28526551/assessment-of-vertical-ridge-augmentation-in-anterior-aesthetic-zone-using-onlay-xenografts-with-titanium-mesh-versus-the-inlay-bone-grafting-technique-a-randomized-clinical-trial
#1
M Mounir, S Mounir, A A Elfetouh, M A Shaker
The aim of this study was to evaluate the final vertical gain at the deficient anterior maxillary alveolar ridges using onlay bone grafts with titanium mesh versus inlay bone grafting. This was a single institutional randomized comparative clinical trial. The study population included 16 patients, with edentulous anterior maxillary alveolar ridges (40 implant sites) who were presented and treated at the Faculty of Oral and Dental Medicine in Cairo University from September 2013 to August 2015. Selected patients were randomly divided into two equal groups...
May 16, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28524543/snapshot-whole-brain-t1-relaxometry-using-steady-state-prepared-spiral-multislice-variable-flip-angle-imaging
#2
Rahel Heule, Josef Pfeuffer, Oliver Bieri
PURPOSE: Variable flip angle (VFA) imaging is widely used for whole-brain T1 quantification. Because of the requirement to acquire at least two sets of MR images at different flip angles, VFA relaxometry is relatively slow. Here, whole-brain VFA T1 mapping at 1.5 T is accelerated by using efficient spiral non-Cartesian imaging METHODS: To quantify T1 in the human brain, radiofrequency spoiled gradient-echo imaging is performed at two optimized flip angles using an interleaved 2D multislice sequence with high spoiling efficiency...
May 19, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28523098/incb24360-epacadostat-a-highly-potent-and-selective-indoleamine-2-3-dioxygenase-1-ido1-inhibitor-for-immuno-oncology
#3
Eddy W Yue, Richard Sparks, Padmaja Polam, Dilip Modi, Brent Douty, Brian Wayland, Brian Glass, Amy Takvorian, Joseph Glenn, Wenyu Zhu, Michael Bower, Xiangdong Liu, Lynn Leffet, Qian Wang, Kevin J Bowman, Michael J Hansbury, Min Wei, Yanlong Li, Richard Wynn, Timothy C Burn, Holly K Koblish, Jordan S Fridman, Tom Emm, Peggy A Scherle, Brian Metcalf, Andrew P Combs
A data-centric medicinal chemistry approach led to the invention of a potent and selective IDO1 inhibitor 4f, INCB24360 (epacadostat). The molecular structure of INCB24360 contains several previously unknown or underutilized functional groups in drug substances, including a hydroxyamidine, furazan, bromide, and sulfamide. These moieties taken together in a single structure afford a compound that falls outside of "drug-like" space. Nevertheless, the in vitro ADME data is consistent with the good cell permeability and oral bioavailability observed in all species (rat, dog, monkey) tested...
May 11, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28507237/multiscale-ordinal-network-analysis-of-human-cardiac-dynamics
#4
M McCullough, M Small, H H C Iu, T Stemler
In this study, we propose a new information theoretic measure to quantify the complexity of biological systems based on time-series data. We demonstrate the potential of our method using two distinct applications to human cardiac dynamics. Firstly, we show that the method clearly discriminates between segments of electrocardiogram records characterized by normal sinus rhythm, ventricular tachycardia and ventricular fibrillation. Secondly, we investigate the multiscale complexity of cardiac dynamics with respect to age in healthy individuals using interbeat interval time series and compare our findings with a previous study which established a link between age and fractal-like long-range correlations...
June 28, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28507228/understanding-principles-of-integration-and-segregation-using-whole-brain-computational-connectomics-implications-for-neuropsychiatric-disorders
#5
REVIEW
Louis-David Lord, Angus B Stevner, Gustavo Deco, Morten L Kringelbach
To survive in an ever-changing environment, the brain must seamlessly integrate a rich stream of incoming information into coherent internal representations that can then be used to efficiently plan for action. The brain must, however, balance its ability to integrate information from various sources with a complementary capacity to segregate information into modules which perform specialized computations in local circuits. Importantly, evidence suggests that imbalances in the brain's ability to bind together and/or segregate information over both space and time is a common feature of several neuropsychiatric disorders...
June 28, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28502428/non-proximate-mass-spectrometry-using-a-heated-1-m-long-ptfe-tube-and-an-air-tight-apci-ion-source
#6
Dilshadbek T Usmanov, Kenzo Hiraoka, Hiroshi Wada, Masaya Matsumura, Sachiyo Sanada-Morimura, Hiroshi Nonami, Shinichi Yamabe
Direct and rapid trace-level gas analysis is highly needed in various fields such as safety and security, quality control, food analysis, and forensic medicine. In many cases, the real samples are bulky and are not accessible to the space-limited ion source of the mass spectrometer. In order to circumvent this problem, we developed an airtight atmospheric-pressure chemical ionization (APCI) ion source equipped with a flexible 1-m-long, 2-mm-i.d. PTFE sniffing tube. The ambient air bearing sample gas was sucked into the heated PTFE tube (130 °C) and was transported to the air-tight ion source without using any extra pumping system or a Venturi device...
June 22, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28501806/exercise-in-type-2-diabetes-genetic-metabolic-and-neuromuscular-adaptations-a-review-of-the-evidence
#7
REVIEW
Silvano Zanuso, Massimo Sacchetti, Carl Johan Sundberg, Giorgio Orlando, Paolo Benvenuti, Stefano Balducci
The biological responses to exercise training are complex, as almost all organs and systems are involved in interactions that result in a plethora of adaptations at the genetic, metabolic and neuromuscular levels.To provide the general practitioner and the sports medicine professionals with a basic understanding of the genetic, metabolic and neuromuscular adaptations at a cellular level that occur with aerobic and resistance exercise in subjects with type 2 diabetes.For each of the three domains (genetic, metabolic and neuromuscular), the results of the major systematic reviews and original research published in relevant journals, indexed in PubMed, were selected...
May 13, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28499990/a-state-space-and-density-estimation-framework-for-sleep-staging-in-obstructive-sleep-apnea
#8
Dae Y Kang, Pamela N DeYoung, Atul Malhotra, Robert L Owens, Todd P Coleman
OBJECTIVE: Although the importance of sleep is increasingly recognized, the lack of robust and efficient algorithms hinders scalable sleep assessment in healthy persons and those with sleep disorders. Polysomnography (PSG) and visual/manual scoring remain the gold standard in sleep evaluation, but more efficient/automated systems are needed. Most previous works have demonstrated algorithms in high agreement with the gold standard in healthy/normal (HN) individuals - not those with sleep disorders...
May 8, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28498966/genprobis-web-server-for-mapping-of-sequence-variants-to-protein-binding-sites
#9
Janez Konc, Blaz Skrlj, Nika Erzen, Tanja Kunej, Dusanka Janezic
Discovery of potentially deleterious sequence variants is important and has wide implications for research and generation of new hypotheses in human and veterinary medicine, and drug discovery. The GenProBiS web server maps sequence variants to protein structures from the Protein Data Bank (PDB), and further to protein-protein, protein-nucleic acid, protein-compound, and protein-metal ion binding sites. The concept of a protein-compound binding site is understood in the broadest sense, which includes glycosylation and other post-translational modification sites...
May 11, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28497643/three-dimensional-ultrashort-echo-time-mri-and-short-t2-images-generated-from-subtraction-for-determination-of-tumor-burden-in-lung-cancer-preclinical-investigation-in-transgenic-mice
#10
Andreas Müller, Philippe Jagoda, Peter Fries, Stefan Gräber, Robert Bals, Arno Buecker, Christopher Jungnickel, Christoph Beisswenger
PURPOSE: To investigate the potential of 3D ultrashort echo time MRI and short T2 images generated by subtraction for determination of total tumor burden in lung cancer. METHODS: As an animal model of spontaneously developing non-small cell lung cancer, the K-rasLA1 transgenic mouse was used. Three-dimensional MR imaging was performed with radial k-space acquisition and echo times of 20 µs and 1 ms. For investigation of the short T2 component in the recorded signal, subtraction images were generated from these data sets and used for consensus identification of tumors...
May 11, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28497620/accelerated-whole-heart-mr-angiography-using-a-variable-density-poisson-disc-undersampling-pattern-and-compressed-sensing-reconstruction
#11
Mehdi H Moghari, Martin Uecker, Sébastien Roujol, Majid Sabbagh, Tal Geva, Andrew J Powell
PURPOSE: To accelerate whole-heart three-dimension MR angiography (MRA) by using a variable-density Poisson-disc undersampling pattern and a compressed sensing (CS) reconstruction algorithm, and compare the results with sensitivity encoding (SENSE). METHODS: For whole-heart MRA, a prospective variable-density Poisson-disc k-space undersampling pattern was developed in which 1-2% of central part of k-space was fully sampled, and sampling in the remainder decreased exponentially toward the periphery...
May 11, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28497486/5d-whole-heart-sparse-mri
#12
Li Feng, Simone Coppo, Davide Piccini, Jerome Yerly, Ruth P Lim, Pier Giorgio Masci, Matthias Stuber, Daniel K Sodickson, Ricardo Otazo
PURPOSE: A 5D whole-heart sparse imaging framework is proposed for simultaneous assessment of myocardial function and high-resolution cardiac and respiratory motion-resolved whole-heart anatomy in a single continuous noncontrast MR scan. METHODS: A non-electrocardiograph (ECG)-triggered 3D golden-angle radial balanced steady-state free precession sequence was used for data acquisition. The acquired 3D k-space data were sorted into a 5D dataset containing separated cardiac and respiratory dimensions using a self-extracted respiratory motion signal and a recorded ECG signal...
May 11, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28494997/multiple-model-predictive-control-for-optimal-drug-administration-of-mixed-immunotherapy-and-chemotherapy-of-tumours
#13
N Sharifi, S Ozgoli, A Ramezani
BACKGROUND: Mixed immunotherapy and chemotherapy of tumours is one of the most efficient ways to improve cancer treatment strategies. However, it is important to 'design' an effective treatment programme which can optimize the ways of combining immunotherapy and chemotherapy to diminish their imminent side effects. Control engineering techniques could be used for this. METHODS: The method of multiple model predictive controller (MMPC) is applied to the modified Stepanova model to induce the best combination of drugs scheduling under a better health criteria profile...
June 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28489466/intrathecal-injection-of-gadobutrol-a-tale-of-caution
#14
Corey Reeves, Enrique Galang, Raj Padalia, Nam Tran, Devang Padalia
In the field of interventional pain medicine a radiocontrast agent is commonly used in conjunction with fluoroscopy. Limited work has been published regarding the use of gadolium based contrast agents (GBCA) in the intrathecal space. We report a case of an intrathecal gadobutrol injection resulting in neurotoxic manifestations.A 60-year-old female with a history significant for lumbar post-laminectomy syndrome and intrathecal drug delivery implantation was admitted for lumbar fusion and kyphoplasty. Postoperatively, the patient had escalating pain medication requirements...
May 10, 2017: Journal of Pain & Palliative Care Pharmacotherapy
https://www.readbyqxmd.com/read/28488234/microphysiological-human-brain-and-neural-systems-on-a-chip-potential-alternatives-to-small-animal-models-and-emerging-platforms-for-drug-discovery-and-personalized-medicine
#15
Alexander P Haring, Harald Sontheimer, Blake N Johnson
Translational challenges associated with reductionist modeling approaches, as well as ethical concerns and economic implications of small animal testing, drive the need for developing microphysiological neural systems for modeling human neurological diseases, disorders, and injuries. Here, we provide a comprehensive review of microphysiological brain and neural systems-on-a-chip (NSCs) for modeling higher order trajectories in the human nervous system. Societal, economic, and national security impacts of neurological diseases, disorders, and injuries are highlighted to identify critical NSC application spaces...
May 10, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28487160/good-vibrations-assessing-the-stability-of-snake-venom-composition-after-researcher-induced-disturbance-in-the-laboratory
#16
Natalie M Claunch, Matthew L Holding, Camilo Escallón, Ben Vernasco, Ignacio T Moore, Emily N Taylor
Phenotypic plasticity contributes to intraspecific variation in traits of many animal species. Venom is an integral trait to the success and survival of many snake species, and potential plasticity in venom composition is important to account for in the context of basic research as well as in human medicine for treating the various symptoms of snakebite and producing effective anti-venoms. Researchers may unknowingly induce changes in venom variation by subjecting snakes to novel disturbances and potential stressors...
May 6, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28486209/bioactivity-guided-mixed-synthesis-accelerate-the-serendipity-in-lead-optimization-discovery-of-fungicidal-homodrimanyl-amides
#17
Dangdang Li, Shasha Zhang, Zehua Song, Guotong Wang, Shengkun Li
The bioactivity-guided mixed synthesis was conceived, in which the designed mix-reactions were run in parallel for simultaneous construction of different kinds of analogs. The valuable ones were protruded by biological screening. This tactic will facilitate more rapid incorporation of bioactive candidates into pesticide chemists' repertoire, exemplified by the optimization of less explored homodrimanes as antifungal ingredients. The discovery of D9 as a potent fungicidal agent can be completed in <2 weeks by one student, with EC50 of 3...
May 2, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28484301/comparative-analysis-of-family-medicine-education-and-exams-at-cathedras-of-family-medicine-of-universities-in-southeastern-europe-splitska-inicijativa-sarajevo-2017
#18
Izet Masic, Olivera Batic Mujanovic, Maja Racic, Larisa Gavran, Kosana Stanetic, Merzika Hodzic, Milena Cojic, Ljiljana Cvejanov-Kezunovic, Aleksandar Stepanovic, Katarina Stavrikj, Zaim Jatic, Edita Cerny Obrdalj, Amra Zalihic, Ksenija Tusek-Bunc
Education means: learning, teaching or the process of acquiring skills or behavior modification through various exercises. Traditionally, medical education meant the oral, practical and more passive transferring of knowledge and skills from the educators to students and health professionals. Today the importance of focus on educational quality, particularly in the professions operating in the services required by people is agreed by all involved. The higher educational system shoulders some critical responsibilities in the economic, social, cultural and educational development and growth in the communities...
March 2017: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/28483696/spatial-distributions-of-pericellular-stiffness-in-natural-extracellular-matrices-are-dependent-on-cell-mediated-proteolysis-and-contractility
#19
M Keating, A Kurup, M Alvarez-Elizondo, A J Levine, E Botvinick
Bulk tissue stiffness has been correlated with regulation of cellular processes and conversely cells have been shown to remodel their pericellular tissue according to a complex feedback mechanism critical to development, homeostasis, and disease. However, bulk rheological methods mask the dynamics within a heterogeneous fibrous extracellular matrix (ECM) in the region proximal to a cell (pericellular region). Here, we use optical tweezers active microrheology (AMR) to probe the distribution of the complex material response function (α = α' + α'', in units of µm/nN) within a type I collagen ECM, a biomaterial commonly used in tissue engineering...
May 5, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28480537/accelerated-noncontrast-enhanced-4-dimensional-intracranial-mr-angiography-using-golden-angle-stack-of-stars-trajectory-and-compressed-sensing-with-magnitude-subtraction
#20
Ziwu Zhou, Fei Han, Songlin Yu, Dandan Yu, Stanislas Rapacchi, Hee Kwon Song, Danny J J Wang, Peng Hu, Lirong Yan
PURPOSE: To evaluate the feasibility and performance of compressed sensing (CS) with magnitude subtraction regularization in accelerating non-contrast-enhanced dynamic intracranial MR angiography (NCE-dMRA). METHODS: A CS algorithm was introduced in NCE-dMRA by exploiting the sparsity of the magnitude difference of the control and label images. The NCE-dMRA data were acquired using golden-angle stack-of-stars trajectory on six healthy volunteers and one patient with arteriovenous fistula...
May 7, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
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