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https://www.readbyqxmd.com/read/28705508/fingerprint-analysis-of-gelsemium-elegans-by-hplc-followed-by-the-targeted-identification-of-chemical-constituents-using-hplc-coupled-with-quadrupole-time-of-flight-mass-spectrometry
#1
Yan-Chun Liu, Li Lin, Pi Cheng, Zhi-Liang Sun, Yong Wu, Zhao-Ying Liu
Gelsemium elegans, which is a genus of the family Loganiaease, is commonly used as a traditional medicine for promoting animal growth and treating rheumatoid arthritis pain and neuropathic pain, among others. In this study, we first established a valid high-performance liquid chromatography (HPLC) method for the fingerprint analysis of Gelsemium elegans samples. Then, the comprehensive detection of chemical constituents from the samples was performed using HPLC coupled with quadrupole-time-of-flight mass spectrometry...
July 10, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28704842/analysis-of-metabolomic-profile-of-fermented-orostachys-japonicus-a-berger-by-capillary-electrophoresis-time-of-flight-mass-spectrometry
#2
Gitishree Das, Jayanta Kumar Patra, Sun-Young Lee, Changgeon Kim, Jae Gyu Park, Kwang-Hyun Baek
Microbial cell performance in food biotechnological processes has become an important concern for improving human health worldwide. Lactobacillus plantarum, which is widely distributed in nature, is a lactic acid bacterium with many industrial applications for fermented foods or functional foods (e.g., probiotics). In the present study, using capillary electrophoresis time of flight mass spectrometry, the metabolomic profile of dried Orostachys japonicus A. Berger, a perennial medicinal herb with L. plantarum was compared with that of O...
2017: PloS One
https://www.readbyqxmd.com/read/28702943/screening-and-identification-of-metabolites-of-two-kinds-of-main-active-ingredients-and-hepatotoxic-pyrrolizidine-alkaloids-hpas-in-rat-after-lavage-farfarae-flos-extract-by-uhplc-q-tof-ms-mass-spectrometry
#3
Xiaoye Cheng, Man Liao, Xinpeng Diao, Yupeng Sun, Lantong Zhang
Farfarae Flos, the dried flower buds of Tussilago farfara L., is usually used to treat coughs, bronchitic and asthmatic conditions as an important traditional Chinese medicine. Tussilagone and methl butyric acid tussilagin ester are seen as representatives of two kinds of active substances. Besides, the pyrrolizidine alkaloids (HPAs), mainly senkirkine and senecionine, presented in the herb can be hepatoxic. In this study, a rapid and sensitive ultra high performance liquid chromatography coupled with hybrid triple quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS) method is successfully applied to identify the metabolites of tussilagone, methl butyric acid tussilagin ester , senkirkine and senecionine...
July 12, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28701067/metabolomic-approach-to-understand-the-acute-and-chronic-hepatotoxicity-of-veratrum-nigrum-extract-in-mice-based-on-ultra-high-performance-liquid-chromatography-coupled-with-quadrupole-time-of-flight-mass-spectrometry
#4
Ziheng Wei, Qingqing Qian, Xu Dong, Na Li, Guangchun Sun, Songyan Gao, Xin Dong
Veratrum nigrum L. (VN) is a poisonous traditional Chinese Medicine herb with thousands of years in China. Clinical studies have shown that VN has ability to cause hepatotoxicity, which severely limits its clinical use. The mechanism of its hepatotoxicity has not been fully elucidated. The purpose of this study was to develop and characterize a model of acute and chronic hepatotoxicity induced by Veratrum nigrum L. extract (VNE) to understand the mechanism by the liver tissue metabolomics approach based on ultra high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOFMS)...
July 13, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28700524/challenges-for-detecting-valproic-acid-in-a-nontargeted-urine-drug-screening-method
#5
Jeffrey D Pope, Marion J Black, Olaf H Drummer, Hans G Schneider
BACKGROUND: Valproic acid (VPA) is a widely prescribed medicine, and acute toxicity is possible. As such, it should be included in any nontargeted urine drug screening method. In many published liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS/MS) methods, VPA is usually measured using a pseudo-multiple reaction monitoring (MRM) transition. We investigate a simple ultra-high-performance liquid chromatography-quadrupole time-of-flight (QTof) approach to detect the presence of VPA with more confidence...
August 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28688664/a-novel-flight-surgeon-training-model-at-a-joint-military-and-civilian-surgical-residency-program
#6
Erik S DeSoucy, Scott A Zakaluzny, Joseph M Galante
BACKGROUND: Graduating military preliminary interns are often required to fill flight surgeon billets. General surgery preliminary interns get experience evaluating surgical and trauma patients, but receive very little training in primary care and flight medicine. At a joint military and civilian training program, we developed a supplemental curriculum to help transition our interns into flight medicine. METHODS: From 2013 to 2016, we developed a lecture series focused on aerospace medicine, primary care, and specialty topics including dermatology, ophthalmology, orthopedics, pediatrics, psychiatry, and women's health...
July 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28687866/quantification-improvement-and-harmonization-of-small-lesion-detection-with-state-of-the-art-pet
#7
REVIEW
Charlotte S van der Vos, Daniëlle Koopman, Sjoerd Rijnsdorp, Albert J Arends, Ronald Boellaard, Jorn A van Dalen, Mark Lubberink, Antoon T M Willemsen, Eric P Visser
In recent years, there have been multiple advances in positron emission tomography/computed tomography (PET/CT) that improve cancer imaging. The present generation of PET/CT scanners introduces new hardware, software, and acquisition methods. This review describes these new developments, which include time-of-flight (TOF), point-spread-function (PSF), maximum-a-posteriori (MAP) based reconstruction, smaller voxels, respiratory gating, metal artefact reduction, and administration of quadratic weight-dependent (18)F-fluorodeoxyglucose (FDG) activity...
July 8, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28687792/maldi-tof-ms-as-a-novel-tool-for-the-estimation-of-postmortem-interval-in-liver-tissue-samples
#8
Chengzhi Li, Zhengdong Li, Ya Tuo, Dong Ma, Yan Shi, Qinghua Zhang, Xianyi Zhuo, Kaifei Deng, Yijiu Chen, Zhenyuan Wang, Ping Huang
Estimation of the postmortem interval (PMI) is a complicated task in forensic medicine, especially during homicide and unwitnessed death investigations. Many biological, chemical, and physical indicators can be used to determine the postmortem interval, but most are not accurate. Here, we present a novel matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) method that can be used for the estimation of PMI using molecular images and multivariate analyses. In this study, we demonstrate that both rat and human liver tissues of various PMIs (0, 2, 4, and 6days) can be discriminated using MALDI imaging and principal component analysis (PCA)...
July 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28683180/multiconstituent-identification-in-root-branch-and-leaf-extracts-of-juglans-mandshurica-using-ultra-high-performance-liquid-chromatography-with-quadrupole-time-of-flight-mass-spectrometry
#9
Tian-Min Wang, Jing Liu, Tao Yi, Yan-Jun Zhai, Hui Zhang, Hu-Biao Chen, Shao-Qing Cai, Ting-Guo Kang, Zhong-Zhen Zhao
As a folk medicinal plant, Juglans mandshurica has been used for the treatment of cancer. Different organs of this plant showed anti-tumor activity in clinic and laboratory. Comparative identification of constituents in different plant organs is essential for investigation of the relationship between chemical constituents and pharmacological activities. For this aim, the roots, branches, and leaves of J. mandshurica were extracted with 50% v/v methanol and then subjected to ultra high performance liquid chromatography with quadrupole time-of-flight mass spectrometry analysis conducted under low and high energy...
July 6, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28677911/characterization-and-discrimination-of-raw-and-vinegar-baked-bupleuri-radix-based-on-uhplc-q-tof-ms-coupled-with-multivariate-statistical-analysis
#10
Tianli Lei, Shifeng Chen, Kai Wang, Dandan Zhang, Lin Dong, Chongning Lv, Jing Wang, Jincai Lu
Bupleuri Radix is a commonly used herb in clinic, and raw and vinegar-baked Bupleuri Radix are both documented in the Pharmacopoeia of People's Republic of China. According to the theories of traditional Chinese medicine, Bupleuri Radix possesses different therapeutic effects before and after processing. However, the chemical mechanism of this processing is still unknown. In this study, an ultra-high performance liquid chromatography with quadruple time-of-flight mass spectrometry coupled with multivariate statistical analysis including principal component analysis and orthogonal partial least square-discriminant analysis was developed to holistically compare the difference between raw and vinegar-baked Bupleuri Radix for the first time...
July 5, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28672255/lipidomics-to-investigate-the-pharmacologic-mechanisms-of-ginkgo-folium-in-the-hyperuricemic-rat-model
#11
Shuli Zhang, Jingcong Zhuang, Guijuan Yue, Yiping Wang, Mingyu Liu, Bing Zhang, Zhenxia Du, Qun Ma
Hyperuricemia caused by purine metabolic abnormalities is reported to have close correlation with lipid metabolic disorders. Ginkgo folium, a frequently-used lipid-lowering medicine, has significant anti-hyperuricemia effects. However, it is poorly known about the interaction between lowering uric acid and regulation of lipid metabolic disorders. In this study, hyperuricemic rat model was induced by orally administration with fructose. Ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF/MS) combined with pattern recognition approaches were used to determine different lipid metabolites in serum of control group, model group, and different doses of ginkgo folium groups...
June 20, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28669684/urinary-metabolomic-analysis-of-intrahepatic-cholestasis-of-pregnancy-based-on-high-performance-liquid-chromatography-mass-spectrometry
#12
Li Ma, Xiaoqing Zhang, Feng Pan, Yue Cui, Ting Yang, Linlin Deng, Yong Shao, Min Ding
BACKGROUND: Intrahepatic cholestasis of pregnancy (ICP), a pregnancy-related liver disease, leads to complications for both mothers and fetuses. Metabolomic approach has been applied to maternal-fetal medicine. The global metabolomic alterations that are specific in ICP as yet have not been investigated. METHODS: Based on high performance liquid chromatography/hybrid quadrupole time-of-flight (HPLC/Q-TOF) mass spectrometry, the untargeted metabolomics was used to analyze the changes of urinary metabolites between ICP group and the control group...
June 29, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28667680/fast-and-comprehensive-characterization-of-chemical-ingredients-in-traditional-chinese-herbal-medicines-by-extractive-atmospheric-pressure-photoionization-eappi-mass-spectrometry
#13
Chengyuan Liu, Wu Wen, Jun Shao, Wan Zhao, Keke Qi, Jiuzhong Yang, Yang Pan
RATIONALE: The goal of this work is to employ extractive atmospheric pressure photoionization mass spectrometry (EAPPI MS) to characterize the constituents in traditional Chinese herbal medicine (TCHM) directly without chromatographic separation. METHODS: Sample was placed in 4 mL of methanol/water (v:v=3:1) in the nebulization cell, and then the ultrasonic nebulizer was switched on. Ultrasonic nebulization system allows the simultaneous sample extraction and introduction of extract aerosols...
July 1, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28666227/comprehensive-profiling-and-characterization-of-chemical-constituents-of-rhizome-of-anemarrhena-asphodeloides-bge
#14
De Ji, Zi-Yan Huang, Cheng-Hao Fei, Wei-Wei Xue, Tu-Lin Lu
The rhizome of Anemarrhena asphodeloides Bge. is commonly used as an herbal medicine in China. In this study, ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS) was used, in both negative and positive ion modes, to comprehensively analyze the chemical constituents of A. asphodeloides. From the intact precursor ions, MS/MS fragmentation information, and previous reports, we identified 89 compounds. These compounds included 8 cyclic peptides, 11 flavones (9 xanthones), 45 steroidal saponins, 15 fatty acids, 3 lignans, and 7 other compounds...
June 19, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28666162/metabolic-profiling-analysis-of-siraitia-grosvenorii-revealed-different-characteristics-of-green-fruit-and-saccharified-yellow-fruit
#15
Chengnan Fang, Qingqing Wang, Xinyu Liu, Guowang Xu
Siraitia grosvenorii is an economic and medicinal plant, its fruit is considered to be good to health for its diverse bioactive ingredients. However, the clarification of chemical composition and their changes after saccharification procedure are not well performed. In present study, a metabolomics method based on ultra-high-performance liquid chromatography tandem quadrupole time-of-flight mass spectrometry was developed for metabolic profiling acquisition of Siraitia grosvenorii extract. Furthermore, information dependent analysis (IDA) combined with self-constructed LC-MS/MS identification system for metabolites were employed to identify primary and secondary metabolites in Siraitia grosvenorii...
June 20, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28656200/cardioprotective-effects-and-mechanism-of-radix-salviae-miltiorrhizae-and-lignum-dalbergiae-odoriferae-on-rat-myocardial-ischemia-reperfusion-injury
#16
Fei Mu, Jialin Duan, Haixu Bian, Ying Yin, Yanrong Zhu, Guo Wei, Yue Guan, Yanhua Wang, Chao Guo, Aidong Wen, Yong Yang, Miaomiao Xi
Radix Salviae miltiorrhizae (SM) and Lignum Dalbergiae odoriferae (DO) are traditional Chinese medicinal herbs used to treat ischemic heart disease and other cardiovascular diseases; however, to the best of our knowledge, there are currently few studies regarding their effects. The present study aimed to investigate the cardioprotective effects of SM and DO during myocardial ischemia/reperfusion (MI/R) injury in rats, and explore the molecular mechanisms that underlie their actions. In the present study, Sprague‑Dawley rats were pretreated with SM, the aqueous extract of DO (DOA) and the volatile oil of DO (DOO), either as a monotherapy or in combination for 7 days...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28653926/comparison-of-the-curdione-in-brain-of-blood-stasis-pregnant-rats-and-its-offsprings-with-the-normal-group-rats-by-uplc-q-tof-ms
#17
Bo Hong, Wenjing Li, Miaoxian Dong, Yingcai Niu
Curdione is a main active component of curcuma rhizomes (Ezhu), which shows an excellent antithrombotic activity. In this study, the concentration of Curdione in pregnant rats and their offspring brain was determined using ultra-performance liquid chromatography-quadrupole time-of-flight/mass spectrometry (UPLC-Q-TOF-MS) method. The water extraction then alcohol precipitation extract from Ezhu was administered through tail intravenous injection. The pharmacokinetic parameters were analyzed to compare the differences between the blood stasis group rats and normal group rats...
May 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28651109/separation-of-furostanol-saponins-by-supercritical-fluid-chromatography
#18
Jie Yang, Lingling Zhu, Yang Zhao, Yongwei Xu, Qinglong Sun, Shuchen Liu, Chao Liu, Baiping Ma
Supercritical fluid chromatography (SFC) has good separation efficiency and is suitable for separating weakly polar compounds. Furostanol saponins, as an important kind of steroidal saponins, generally have two sugar chains, which are polar and hydrophilic. The hydroxyl group at the C-22 position of furostanol saponins is active and easily reacts with lower alcohols under appropriate conditions. The separation of hydrophilic furostanol saponins was tested by SFC in this study. The effects of chromatographic conditions on the separation of the mixed furostanol saponins and their hydroxyl derivatives at the C-22 position were studied...
June 19, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28644981/chemical-profiling-and-antioxidant-evaluation-of-yangxinshi-tablet-by-hplc-esi-q-tof-ms-ms-combined-with-dpph-assay
#19
Junfeng Zhu, Xiaojiao Yi, Jinghui Zhang, Shuqing Chen, Yongjiang Wu
Yangxinshi Tablet (YXST) is a Chinese patent medicine commonly used to treat cardiovascular diseases. However, its detailed chemical basis and mechanisms of action have not been clarified. In this study, high performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry (HPLC-ESI-Q-TOF-MS) was applied for comprehensive analysis of the chemical constituents in YXST. A total of 127 compounds, including 19 phenolic acids, 12 alkaloids, 51 flavanoids, 32 triterpenoids, 2 lignans, 2 phenylethanoid glycosides, 2 anthraquinones, 1 coumarin, and 6 other compounds, were identified or tentatively deduced by comparing their retention times and MS spectra with those of authentic standards or literature data...
June 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28643853/qualitative-analysis-of-polyphenols-in-macroporous-resin-pretreated-pomegranate-husk-extract-by-hplc-qtof-ms
#20
Rahima Abdulla, Sanawar Mansur, Haizhong Lai, Ablikim Ubul, Guangying Sun, Guozheng Huang, Haji Akber Aisa
INTRODUCTION: Pomegranate (Punica granatum L.) husk is a traditional herbal medicine abundant in phenolic compounds and plays some roles in the treatment of oxidative stress, bacterial and viral infection, diabetes mellitus, and acute and chronic inflammation. OBJECTIVE: Identification and determination of polyphenols in macroporous resin pretreated pomegranate husk extract by high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (HPLC-QTOF-MS)...
June 23, 2017: Phytochemical Analysis: PCA
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