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https://www.readbyqxmd.com/read/29758474/purification-and-characterization-of-two-pathogenesis-related-class-10-protein-isoforms-with-ribonuclease-activity-from-the-fresh-angelica-sinensis-roots
#1
Jianru Pan, Xiangling Wang, Lingling Li, Xian Li, Xiaoqiang Ye, Di Lv, Cuihuang Chen, Shutao Liu, Huocong He
In this study, two pathogenesis-related (PR) class 10 protein isoforms, ASPR-1 and ASPR-2, were purified from fresh roots of the Chinese medicinal plant Angelica sinensis (A. sinensis) using 80% ammonium sulfate precipitation, Sephadex G50 gel filtration chromatography, and DEAE-Sepharose ion-exchange chromatography. The molecular masses of ASPR-1 and ASPR-2 were estimated to be 16.66 kDa and 16.46 kDa, respectively, using sodium dodecylsulfate-polyacrylamide gel electrophoresis (SDS-PAGE). The isoforms are both glycoproteins containing glycosyl contents of 1...
April 30, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29752217/mass-spectrometric-identification-of-urinary-biomarkers-of-pulmonary-tuberculosis
#2
Flonza Isa, Sean Collins, Myung Hee Lee, Diessy Decome, Nancy Dorvil, Patrice Joseph, Lauren Smith, Stephen Salerno, Martin T Wells, Steven Fischer, James M Bean, Jean W Pape, Warren D Johnson, Daniel W Fitzgerald, Kyu Y Rhee
BACKGROUND: Tuberculosis (TB) is the leading infectious cause of death worldwide. A major barrier to control of the pandemic is a lack of clinical biomarkers with the ability to distinguish active TB from healthy and sick controls and potential for development into point-of-care diagnostics. METHODS: We conducted a prospective case control study to identify candidate urine-based diagnostic biomarkers of active pulmonary TB (discovery cohort) and obtained a separate blinded "validation" cohort of confirmed cases of active pulmonary TB and controls with non-tuberculous pulmonary disease for validation...
April 22, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29751518/simultaneous-analysis-of-iridoid-glycosides-and-anthraquinones-in-morinda-officinalis-using-uplc-qqq-ms-ms-and-uplc-q-tof-ms-e
#3
Xiangsheng Zhao, Jianhe Wei, Meihua Yang
Morinda officinalis is an important herbal medicine and functional food, and its main constituents include anthraquinone and iridoid glycosides. Quantification of the main compounds is a necessary step to understand the quality and therapeutic properties of M. officinalis , but this has not yet been performed based on liquid chromatography/tandem mass spectrometry (LC-MS/MS). Analytes were extracted from M. officinalis by reflux method. Ultrahigh-performance liquid chromatography coupled with a triple quadrupole mass spectrometry (UPLC-QqQ-MS) using multiple reaction monitoring (MRM) mode was applied for quantification...
May 3, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29751287/chemical-profiling-in-moutan-cortex-after-sulfuring-and-desulfuring-processes-reveals-further-insights-into-the-quality-control-of-tcms-by-nontargeted-metabolomic-analysis
#4
Zhi-Lai Zhan, Ai-Ping Deng, Li-Ping Kang, Jin-Fu Tang, Tie-Gui Nan, Tong Chen, Ya-Li He, Lan-Ping Guo, Lu-Qi Huang
As a traditional processing method, sulfuring has been used in the processing of many traditional Chinese medicines (TCMs). Desulfuring, which has emerged in recent years, is a new method applied to sulfured herbs so they can comply with regulations regarding residual SO2 . Due to the chemical transformations and the residual SO2 in the herbs, both sulfuring and desulfuring have negative effects on the safety and therapeutic effects of TCMs, and Moutan Cortex is one of the TCMs most susceptible to these effects...
May 1, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29734072/a-dilute-and-shoot-multispectral-integration-approach-towards-nontargeted-component-profiling-of-traditional-herbal-yin-zhi-huang-using-liquid-chromatography-photodiode-array-ion-trap-time-of-flight-characterization
#5
Meiling Wang, Yu Liu, Bin Guo, Lijuan Wei, Hao Teng, Xiaoqing Chen, Ming Ma
Ying-zhi-huang Injection (YZH-I) is a classic intravenous formulation of polyherbal Chinese medicine which has been prescribed to treat severe jaundice and acute hepatitis for nearly 50 years. Despite some published data on its major components in the constituent herbs, the overall chemical profile of the potentially bioactive ingredients in YZH-I formula remains largely unknown. Here we developed a multispectral integration approach towards nontargeted phytochemical profiling of YZH-I by liquid chromatography-ultraviolet diode array detector coupled to ion trap/time-of-flight multistage mass spectrometry (LC-DAD-IT(MSn )/TOF) with fast polarity-switching mode...
April 27, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29730774/in-flight-cardiac-arrest-and-in-flight-cardiopulmonary-resuscitation-during-commercial-air-travel-consensus-statement-and-supplementary-treatment-guideline-from-the-german-society-of-aerospace-medicine-dglrm
#6
Jochen Hinkelbein, Lennert Böhm, Stefan Braunecker, Harald V Genzwürker, Steffen Kalina, Fabrizio Cirillo, Matthieu Komorowski, Andreas Hohn, Jörg Siedenburg, Michael Bernhard, Ilse Janicke, Christoph Adler, Stefanie Jansen, Eckard Glaser, Pawel Krawczyk, Mirko Miesen, Janusz Andres, Edoardo De Robertis, Christopher Neuhaus
By the end of the year 2016, approximately 3 billion people worldwide travelled by commercial air transport. Between 1 out of 14,000 and 1 out of 50,000 passengers will experience acute medical problems/emergencies during a flight (i.e., in-flight medical emergency). Cardiac arrest accounts for 0.3% of all in-flight medical emergencies. So far, no specific guideline exists for the management and treatment of in-flight cardiac arrest (IFCA). A task force with clinical and investigational expertise in aviation, aviation medicine, and emergency medicine was created to develop a consensus based on scientific evidence and compiled a guideline for the management and treatment of in-flight cardiac arrests...
May 5, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29730337/multiple-on-line-screening-and-identification-methods-for-hydroxyl-radical-scavengers-in-yudanshen
#7
Yu-Qing Wang, Guo Zhuang, Shu-Jiao Li
Yudanshen, the genuine medicinal materials of Danshen (Salvia miltiorrhiza), is a well-known traditional Chinese medicine (TCM) used to treat cardiovascular and cerebrovascular diseases. Although its pharmacological and antioxidative activities have been well-documented, there is little research on the hydroxyl radical (OH) scavenging capacity of Yudanshen. In this study, we established multiple on-line high-performance liquid chromatography- chemiluminescence detector-diode-quadrupole-time of flight mass spectrometry (HPLC-CL-DAD-Q-TOF/MS) methods to rapidly screen and identify the OH scavengers in Yudanshen simultaneously...
April 27, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29720836/identification-of-potential-anticancer-protein-targets-in-cytotoxicity-mediated-by-tropical-medicinal-fern-extracts
#8
Siok-Thing Tan, Hean-Chooi Ong, Tsun-Thai Chai, Fai-Chu Wong
Background: Medicinal fern species represent a potentially important source for both food and medicinal applications. Previously, two underutilized tropical fern species (Blechnum orientale and Phymatopteris triloba) were reported with cytotoxic activities against selected cancer cell lines. However, the exact mechanism remains elusive. Objective: In this paper, we reported the identification of six differentially expressed proteins isolated from cancer cells, following exposure to the cytotoxic fern extracts...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29713462/immigration-analysis-trends-and-outlook-on-the-global-research-activity
#9
Matthias Trost, Eileen M Wanke, Daniela Ohlendorf, Doris Klingelhöfer, Markus Braun, Jan Bauer, David A Groneberg, David Quarcoo, Dörthe Brüggmann
Background: Immigration has a strong impact on the development of health systems, medicine and science worldwide. Therefore, this article provides a descriptive study on the overall research output. Methods: Utilizing the scientific database Web of Science, data research was performed. The gathered bibliometric data was analyzed using the established platform NewQIS, a benchmarking system to visualize research quantity and quality indices. Findings: Between 1900 and 2016 a total of 6763 articles on immigration were retrieved and analyzed...
June 2018: Journal of Global Health
https://www.readbyqxmd.com/read/29705517/crossing-the-roof-of-the-world-trade-in-medicinal-plants-from-nepal-to-china
#10
Jun He, Bin Yang, Min Dong, Yunshang Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Trade in medicinal and aromatic plants (MAPs) between Nepal and China has taken place for centuries along the Tibetan border. While there is anecdotal evidence that economic development in China over the past decades, coupled with regional infrastructure development and increasing market integration, has substantially changed this trade, there are no current published studies investigating this, e.g. in terms of species and market structure. This knowledge gap impedes the development of public interventions, e...
April 26, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29698861/lc-ms-based-urinary-metabolomics-study-of-the-intervention-effect-of-aloe-emodin-on-hyperlipidemia-rats
#11
Hongyu Ji, Yu Liu, Fang He, Ran An, Zhimin Du
Hyperlipidemia has been highlighted to be one of the most prominent and global chronic condition nowadays. Daming capsule (DMC), a traditional Chinese medicine (TCM) preparation, has treated hyperlipidemia on clinic in China for decades. Our recent study showed that aloe-emodin (AE) is one of the main bioactive components in DMC. Therefore, the present study aims to further investigate the lipid-lowering effect by serum biochemistry and histopathological examination, and reveal the underlying mechanisms by urinary metabolomics approach...
April 16, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29691192/identification-of-pathogenic-and-nonpathogenic-leptospira-species-of-brazilian-isolates-by-matrix-assisted-laser-desorption-ionization-and-time-flight-mass-spectrometry
#12
Daniel Karcher, Rafaella C Grenfell, Andrea Micke Moreno, Luisa Zanolli Moreno, Silvio Arruda Vasconcellos, Marcos B Heinemann, Joao N de Almeida Junior, Luiz Juliano, Maria A Juliano
Matrix Assisted Laser Desorption/Ionization and Time of Flight mass spectrometry (MALDI-TOF MS) is a powerful tool for the identification of bacteria through the detection and analysis of their proteins or fragments derived from ribosomes. Slight sequence variations in conserved ribosomal proteins distinguish microorganisms at the subspecies and strain levels. Characterization of Leptospira spp. by 16S RNA sequencing is costly and time-consuming, and recent studies have shown that closely related species (e...
April 13, 2018: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/29685367/rapid-characterization-of-chemical-markers-for-discrimination-of-moutan-cortex-and-its-processed-products-by-direct-injection-based-mass-spectrometry-profiling-and-metabolomic-method
#13
Chao-Ran Li, Meng-Ning Li, Hua Yang, Ping Li, Wen Gao
BACKGROUND: Processing of herbal medicines is a characteristic pharmaceutical technique in Traditional Chinese Medicine, which can reduce toxicity and side effect, improve the flavor and efficacy, and even change the pharmacological action entirely. It is significant and crucial to perform a method to find chemical markers for differentiating herbal medicines in different processed degrees. PURPOSE: The aim of this study was to perform a rapid and reasonable method to discriminate Moutan Cortex and its processed products, and to reveal the characteristics of chemical components depend on chemical markers...
April 3, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29685335/application-of-characteristic-ion-filtering-with-ultra-high-performance-liquid-chromatography-quadrupole-time-of-flight-tandem-mass-spectrometry-for-rapid-detection-and-identification-of-chemical-profiling-in-eucommia-ulmoides-oliv
#14
Mingzhen He, Jia Jia, Junmao Li, Bei Wu, Wenping Huang, Mi Liu, Yan Li, Shilin Yang, Hui Ouyang, Yulin Feng
Efficient targeted identification of chemical constituents from traditional Chinese medicine is still a major challenge. In this study, we used a characteristic ion filtering strategy to characterize compounds of Eucommia ulmoides Oliv. by ultra-high performance liquid chromatography quadrupole time of flight tandem mass spectrometry (UHPLC-ESI-Q-TOF-MS/MS). By using the ion filtering approach, target constituents of Eucommia ulmoides Oliv. were easily tentatively identified from the enormous LC/MS data set...
April 17, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29681970/-k-nearest-neighbor-algorithm-coupled-with-metabonomics-to-study-the-therapeutic-mechanism-of-sendeng-4-in-adjuvant-induced-rheumatoid-arthritis-rat
#15
Xiye Wang, Dan Li, Mingyang Jiang, Zhili Pei, Liang Xu
As a traditional Mongolian medicine, Sendeng-4 (SD) has been widely used to treat rheumatoid arthritis (RA) in Inner Mongolia and exhibits a good curative effect. Unfortunately, due to geographical factors, it is difficult to popularize this drug throughout the whole country, and the mechanism of action of SD has been unclear. In this study, a serum metabolite profile analysis was performed to identify potential biomarkers associated with adjuvant-induced RA and investigate the mechanism of action of SD. Ultraperformance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) was performed for the metabonomics analysis...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29676080/-quality-evaluation-of-medicinal-herb-decoction-forsythiae-fructus
#16
Jiao Xu, Jung Chao, Yun-Tao Dai, Chao Zhu, Qi Li, Tomoda Takehisa, Dan-Dan Wang, Shi-Lin Chen
To establish the quality control methods for the standard decoction of Forsythiae Fructus. Twelve batches of representative Forsythiae Fructus were collected to prepare standard decoction of Forsythiae Fructus, and then the parameters such as extraction ratio, transfer rate of the index components and pH value of the solution were calculated to evaluate the stability of the process. The simultaneous determination method of target components and fingerprint method were established, and ultra performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) was used to identify the main common peaks in the fingerprint to clarify the main chemical constituents in the decoction...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29676079/-quality-evaluation-of-rhei-radix-et-rhizoma-decoction
#17
Man-Jia Zhao, Jung Chao, Yun-Tao Dai, Shi-Lin Chen, Qi Li, Zi-Quan Fan, Dan-Dan Wang, Takehisa Tomoda
Decoction of single medicinal herb is a reference for the standardization of different dosage forms of Chinese medicine and it provides a new direction for solving the problems existing in the quality of Chinese medicinal granules such as no uniform dosage form and no clear quality standard. In this paper, the quality evaluation method of standard decoction of rhubarb was established to provide reference for the quality control of common dosage forms such as clinical decoction and formula granule. 10 batches of representative Rhei Radix et Rhizoma were collected to establish UPLC fingerprints were established...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29672819/isolation-and-determination-of-phenolic-glycosides-and-anthraquinones-from-rhizomes-of-various-reynoutria-species
#18
Izabela Nawrot-Hadzik, Sebastian Granica, Krzysztof Domaradzki, Łukasz Pecio, Adam Matkowski
Giant knotweeds of the genus Reynoutria (syn. Fallopia )- Reynoutria japonica, Reynoutria sachalinensis , and a hybrid of them, Reynoutria x bohemica -are noxious invasive plants in Europe and North America. R. japonica is a traditional East Asian (Japan and China) drug ( Polygoni cuspidati rhizoma ). Recently, it has been included in European Pharmacopoeia as one of the traditional Chinese medicinal herbs. In this study, a reversed-phase high performance liquid chromatography method with diode array detector and time-of-flight mass spectrometry was developed and validated for the profiling of rhizomes from European invasive populations and Polygoni cuspidati rhizoma purchased in China...
April 19, 2018: Planta Medica
https://www.readbyqxmd.com/read/29669394/identification-of-metabolites-of-helicid-in-vivo-using-ultra-high-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry
#19
Xinpeng Diao, Man Liao, Xiaoye Cheng, Caijuan Liang, Yupeng Sun, Xia Zhang, Lantong Zhang
Helicid is an active natural aromatic phenolic glycoside ingredient originating from well-known traditional Chinese herb medicine and has the significant effects of sedative hypnosis, anti-inflammatory analgesia and antidepressant. In this study, we analyzed the potential metabolites of Helicid in rats by multiple mass defect filter (MMDF)and dynamic background subtraction (DBS)in ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS). Moreover, we used a novel data processing method 'key product ions (KPIs)' to rapidly detect and identifymetabolites as an assistant tool...
April 18, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29668849/qualitative-and-quantitative-analyses-of-active-constituents-in-trollius-ledebourii
#20
Man Liao, Xiaoye Cheng, Xia Zhang, Xinpeng Diao, Caijuan Liang, Lantong Zhang
Trollius ledebourii has been more involved in Mongolian medicine and is often used as a type of tea for heat-clearing and detoxifying in the populus. In this study, a rapid and sensitive method was established for the qualitative and quantitative analyses of the major constituents in T. ledebourii. Ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry was developed for the identification of the multi-constituents in T. ledebourii. A total of 37 chemical constituents in T...
April 13, 2018: Journal of Chromatographic Science
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