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https://www.readbyqxmd.com/read/28644981/chemical-profiling-and-antioxidant-evaluation-of-yangxinshi-tablet-by-hplc-esi-q-tof-ms-ms-combined-with-dpph-assay
#1
Junfeng Zhu, Xiaojiao Yi, Jinghui Zhang, Shuqing Chen, Yongjiang Wu
Yangxinshi Tablet (YXST) is a Chinese patent medicine commonly used to treat cardiovascular diseases. However, its detailed chemical basis and mechanisms of action have not been clarified. In this study, high performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry (HPLC-ESI-Q-TOF-MS) was applied for comprehensive analysis of the chemical constituents in YXST. A total of 127 compounds, including 19 phenolic acids, 12 alkaloids, 51 flavanoids, 32 triterpenoids, 2 lignans, 2 phenylethanoid glycosides, 2 anthraquinones, 1 coumarin, and 6 other compounds, were identified or tentatively deduced by comparing their retention times and MS spectra with those of authentic standards or literature data...
June 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28643853/qualitative-analysis-of-polyphenols-in-macroporous-resin-pretreated-pomegranate-husk-extract-by-hplc-qtof-ms
#2
Rahima Abdulla, Sanawar Mansur, Haizhong Lai, Ablikim Ubul, Guangying Sun, Guozheng Huang, Haji Akber Aisa
INTRODUCTION: Pomegranate (Punica granatum L.) husk is a traditional herbal medicine abundant in phenolic compounds and plays some roles in the treatment of oxidative stress, bacterial and viral infection, diabetes mellitus, and acute and chronic inflammation. OBJECTIVE: Identification and determination of polyphenols in macroporous resin pretreated pomegranate husk extract by high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (HPLC-QTOF-MS)...
June 23, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28628752/high-prevalence-of-resistance-to-fluoroquinolones-and-tetracycline-campylobacter-spp-isolated-from-poultry-in-poland
#3
Anna Woźniak-Biel, Gabriela Bugla-Płoskońska, Alicja Kielsznia, Kamila Korzekwa, Anna Tobiasz, Agnieszka Korzeniowska-Kowal, Alina Wieliczko
Campylobacter spp. is a major cause of foodborne diseases in humans, particularly when transmitted by the handling or consumption of undercooked poultry meat. Most Campylobacter infections are self-limiting, but antimicrobial treatment (e.g., fluoroquinolones and macrolides) is necessary in severe or prolonged cases. The indiscriminate use of these drugs, both in clinical medicine and animal production, has a major impact on public health. The aim of the present study was to identify Campylobacter strains, isolated from turkey and broilers, using both PCR and the matrix-assisted laser desorption-ionization time-of-flight (MALDI-TOF) methods to reveal the accuracy of identification, as well to evaluate the antimicrobial and genetic resistance of the investigated strains...
June 19, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28621737/comprehensive-identification-of-guan-xin-shu-tong-capsule-via-a-mass-defect-and-fragment-filtering-approach-by-high-resolution-mass-spectrometry-in-vitro-and-in-vivo-study
#4
Xun Gao, Jingqing Mu, Qing Li, Shaoyi Guan, Ran Liu, Yiyang Du, Huifen Zhang, Kaishun Bi
The Guan-Xin-Shu-Tong capsule (GXSTC) is a well-known traditional Chinese medicine that is used for the treatment of coronary heart disease. Despite its common use in China, basic pharmacological research on its active components is limited. A comprehensive analytical method using quadrupole-time-of-flight mass spectrometry (Q-TOF/MS), specifically with the Triple TOF 5600 platform, was developed to characterize the compounds in the GXSTC powder itself (in vitro) as well as the active components in healthy and heart disease model rats after its oral administration (in vivo)...
June 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28620200/urinary-metabolomics-reveals-the-therapeutic-effect-of-huangqi-injections-in-cisplatin-induced-nephrotoxic-rats
#5
Chang-Yin Li, Hui-Ting Song, Xiao-Xiao Wang, Yao-Yao Wan, Xuan-Sheng Ding, Shi-Jia Liu, Guo-Liang Dai, Yue-Heng Liu, Wen-Zheng Ju
The side effects of cisplatin (CDDP), notably nephrotoxicity, greatly limited its use in clinical chemotherapy. HuangQi Injections (HI), a commonly used preparation of the well-known Chinese herbal medicine Astragali radix, appeared to be promising treatment for nephrotoxicity without compromising the anti-tumor activity of CDDP. In this study, the urinary metabolomics approach using liquid chromatography time of flight mass spectrometry (LC-TOF/MS) was developed to assess the toxicity-attenuation effects and corresponding mechanisms of HI on CDDP-exposed rats...
June 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28606186/comparison-of-chemical-profiles-between-the-root-and-aerial-parts-from-three-bupleurum-species-based-on-a-uhplc-qtof-ms-metabolomics-approach
#6
Lin Zhu, Zhi-Tao Liang, Tao Yi, Yue Ma, Zhong-Zhen Zhao, Bao-Lin Guo, Jian-Ye Zhang, Hu-Biao Chen
BACKGROUND: Bupleuri Radix (Chaihu) represents one of the most successful and widely used herbal medicines in Asia for the treatment of many diseases such as inflammatory disorders and infectious diseases over the past 2000 years. In the Chinese Pharmacopoeia, Chaihu is recorded as the dried roots of Bupleurum chinense DC. and B. scorzonerifolium Willd. (Umbelliferae). However, the widespread demand for the herb has tended to far outstrip the supply. Whether the aerial parts, which account for 70 ~ 85% of the dry weights of Bupleurum species, could be used as an alternative for the root has become an important scientific issue for the sustainable utilization of Bupleurum species...
June 12, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28577595/a-strategy-to-identify-and-quantify-closely-related-adulterant-herbal-materials-by-mass-spectrometry-based-partial-least-squares-regression
#7
Li Wang, Li-Fang Liu, Jian-Ying Wang, Zi-Qi Shi, Wen-Qi Chang, Meng-Lu Chen, Ying-Hao Yin, Yan Jiang, Hui-Jun Li, Ping Li, Zhong-Ping Yao, Gui-Zhong Xin
In this study, a new strategy combining mass spectrometric (MS) techniques with partial least squares regression (PLSR) was proposed to identify and quantify closely related adulterant herbal materials. This strategy involved preparation of adulterated samples, data acquisition and establishment of PLSR model. The approach was accurate, sensitive, durable and universal, and validation of the model was done by detecting the presence of Fritillaria Ussuriensis Bulbus in the adulteration of the bulbs of Fritillaria unibracteata...
July 18, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28575108/changes-in-the-leaf-proteome-profile-of-withania-somnifera-l-dunal-in-response-to-alternaria-alternata-infection
#8
Varinder Singh, Baldev Singh, Robin Joshi, Puneet Jaju, Pratap Kumar Pati
Withania somnifera is a high value medicinal plant which is used against large number of ailments. The medicinal properties of the plant attributes to a wide array of important secondary metabolites. The plant is predominantly infected with leaf spot pathogen Alternaria alternata, which leads to substantial biodeterioration of pharmaceutically important metabolites. To develop an effective strategy to combat this disease, proteomics based approach could be useful. Hence, in the present study, three different protein extraction methods tris-buffer based, phenol based and trichloroacetic acid-acetone (TCA-acetone) based method were comparatively evaluated for two-dimensional electrophoresis (2-DE) analysis of W...
2017: PloS One
https://www.readbyqxmd.com/read/28574448/simultaneous-quantification-of-multiple-representative-components-in-the-xian-ling-gu-bao-capsule-by-ultra-performance-liquid-chromatography-coupled-with-quadrupole-time-of-flight-tandem-mass-spectrometry
#9
Zhi-Hong Yao, Zi-Fei Qin, Hong Cheng, Xiao-Meng Wu, Yi Dai, Xin-Luan Wang, Ling Qin, Wen-Cai Ye, Xin-Sheng Yao
Xian-Ling-Gu-Bao capsule (XLGB), a famous traditional Chinese medicine prescription, is extensively used for the treatment of osteoporosis in China. However, few studies on the holistic quality control of XLGB have been reported. In this study, a reliable method using 18 representative components in XLGB was successfully established and applied to evaluate 34 batches of XLGB samples by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF-MS). The choice of quantitative markers mostly followed four principles, i...
June 2, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28560574/eortc-pet-response-criteria-are-more-influenced-by-reconstruction-inconsistencies-than-percist-but-both-benefit-from-the-earl-harmonization-program
#10
Charline Lasnon, Elske Quak, Pierre-Yves Le Roux, Philippe Robin, Michael S Hofman, David Bourhis, Jason Callahan, David S Binns, Cédric Desmonts, Pierre-Yves Salaun, Rodney J Hicks, Nicolas Aide
BACKGROUND: This study evaluates the consistency of PET evaluation response criteria in solid tumours (PERCIST) and European Organisation for Research and Treatment of Cancer (EORTC) classification across different reconstruction algorithms and whether aligning standardized uptake values (SUVs) to the European Association of Nuclear Medicine acquisition (EANM)/EARL standards provides more consistent response classification. MATERIALS AND METHODS: Baseline (PET1) and response assessment (PET2) scans in 61 patients with non-small cell lung cancer were acquired in protocols compliant with the EANM guidelines and were reconstructed with point-spread function (PSF) or PSF + time-of-flight (TOF) reconstruction for optimal tumour detection and with a standardized ordered subset expectation maximization (OSEM) reconstruction known to fulfil EANM harmonizing standards...
December 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/28558875/characterization-and-quantitation-of-aristolochic-acid-analogs-in-different-parts-of-aristolochiae-fructus-using-uhplc-q-tof-ms-and-uhplc-qqq-ms
#11
Wen-Wen Mao, Wen Gao, Zhi-Tao Liang, Ping Li, Zhong-Zhen Zhao, Hui-Jun Li
Aristolochiae Fructus, a Chinese herbal medicine derived from the fruit of Aristolochia contorta Bge., contains nephrotoxic aristolochic acid analogues (AAAs). According to ancient medical texts, various medicinal parts of the fruit of A. contorta were ever used. In order to reveal which part could be safely and effectively used, it is necessary to analyze the chemical profiles of different medicinal parts. Herein we compared the chemical compositions and determined aristolochic acid I (AA-I) and aristolochic acid II (AA-II) in the four parts viz...
May 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28557343/progression-of-early-repolarization-patterns-at-a-four-year-follow-up-in-a-female-flight-crew-population-implications-for-aviation-medicine
#12
Gwénolé Rohel, Eric Perrier, Aurélien Delluc, Jonathan Monin, Olivier Manen, Philippe Paule, Marie Piquemal, Jacques Mansourati, Ulric Vinsonneau
BACKGROUND: To assess the prevalence, the appearance, and the distribution, as well as the fluctuation over time of early repolarization patterns after four years in a female population derived from the French aviation sector. METHODS: This was a retrospective longitudinal study from 1998 to 2010 of a population of female employees who received a full clinical examination and an electrocardiogram (ECG) upon their recruitment and after a period of four years. RESULTS: A total of 306 women were included (average of 25...
May 30, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28557041/modified-cuckoo-search-algorithm-in-microscopic-image-segmentation-of-hippocampus
#13
Shouvik Chakraborty, Sankhadeep Chatterjee, Nilanjan Dey, Amira S Ashour, Ahmed S Ashour, Fuqian Shi, Kalyani Mali
Microscopic image analysis is one of the challenging tasks due to the presence of weak correlation and different segments of interest that may lead to ambiguity. It is also valuable in foremost meadows of technology and medicine. Identification and counting of cells play a vital role in features extraction to diagnose particular diseases precisely. Different segments should be identified accurately in order to identify and to count cells in a microscope image. Consequently, in the current work, a novel method for cell segmentation and identification has been proposed that incorporated marking cells...
May 30, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28556969/metabolic-profiling-of-quercetin-in-rats-using-ultra-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry
#14
Ming-Jiang Wu, Xiao-Lei Wu, De-Qin Zhang, Feng Qiu, Li-Qin Ding, Hao-Ling Ma, Xin-Ze Chen
Quercetin, a kind of major flavonoid found in many traditional chinese medicines (TCM), is an effective substance for treatment of diseases such as lowering blood lipid. However, the researches on quercetin have been mainly focused on its pharmacological effect, the treatment of diseases on material basis, particularly the metabolites derived from quercetin in vivo has not been evaluated. In this study, we determined the levels, distributions and types of quercetin's metabolites in plasma, urine, feces and bile of rats after a single oral administration of quercetin at a dose of 80 mg/kg, using ultra-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF/MS)...
May 29, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28544541/identification-and-analysis-of-chemical-constituents-and-rat-serum-metabolites-in-suan-zao-ren-granule-using-ultra-high-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry-combined-with-multiple-data-processing-approaches
#15
Yiyang Du, Bosai He, Qing Li, Jiao He, Di Wang, Kaishun Bi
Suan-Zao-Ren granule is widely used to treat insomnia in China. However, because of the complexity and diversity of the chemical compositions in traditional Chinese medicine formula, the comprehensive analysis of constituents in vitro and in vivo are rather difficult. In our study, an ultra high performance liquid chromatography with quadrupole time-of-flight mass spectrometry and the PeakView® software, which uses multiple data processing approaches including product ion filter, neutral loss filter and mass defect filter, method was developed to characterize the ingredients and rat serum metabolites in Suan-Zao-Ren granule...
May 24, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28532810/species-level-identification-of-coagulase-negative-staphylococcus-spp-from-buffalo-using-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-and-cydb-real-time-quantitative-pcr
#16
Lucas J L Pizauro, Camila C de Almeida, Glenn A Soltes, Durda Slavic, Oswaldo D Rossi-Junior, Fernando A de Ávila, Luiz F Zafalon, Janet I MacInnes
Incorrect identification of Staphylococcus spp. can have serious clinical and zoonotic repercussions. Accordingly, the aim of this study was to determine if matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) and/or cydB real- time quantitative PCR (qPCR) could be used to accurately identify coagulase negative Staphylococcus spp. (CoNS) obtained from buffalo milk and milking environment samples. Seventy-five of 84 CoNS isolates could be identified to the species level (score value >1...
May 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28521273/rapid-discovery-of-cyclopamine-analogs-from-fritillaria-and-veratrum-plants-using-lc-q-tof-ms-and-lc-qqq-ms
#17
Yuan Du, Zu-Guo Zheng, Yue Yu, Zi-Tian Wu, Dan Liang, Ping Li, Yan Jiang, Hui-Jun Li
Cyclopamine, an inhibitor of the Hedgehog (Hh) signaling pathway, has been paid much attention in treating a wide variety of tumors. However, isolation and purification of cyclopamine analogs from medicinal plants remain challengeable. We herein proposed an efficient strategy using liquid chromatography quadrupole-time-of-flight mass spectrometry (LC-Q-TOF-MS) and liquid chromatography triple-quadrupole mass spectrometry (LC-QqQ-MS) for rapid screening and targeted isolation of cyclopamine analogs in Fritillaria and Veratrum plants...
May 1, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28518008/latent-presentation-of-decompression-sickness-after-altitude-chamber-training-in-an-active-duty-flier
#18
James Gentry, Juan Rango, Jianzhong Zhang, Shane Biedermann
BACKGROUND: Decompression sickness (DCS) is a potential danger and risk for both divers and aircrew alike. DCS is also a potential side effect of altitude (hypobaric) chamber training as well and can present long after training occurs. Literature review shows that altitude chamber induced DCS has approximately a 0.25% incidence. CASE REPORT: A 32-yr-old, active duty military member developed symptoms of DCS 3 h after his hypobaric chamber training. Unfortunately, he did not seek treatment for DCS until 48 h after the exposure...
April 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28513568/using-uplc-ms-ms-for-characterization-of-active-components-in-extracts-of-yupingfeng-and-application-to-a-comparative-pharmacokinetic-study-in-rat-plasma-after-oral-administration
#19
COMPARATIVE STUDY
Meng-Qi Jia, Ye-Juan Xiong, Yun Xue, Yan Wang, Chao Yan
Yupingfeng (YPF), a famous traditional Chinese medicine, which contains a large array of compounds, has been effectually used in health protection. A two-dimensional liquid chromatography (²D-LC) combined with quadrupole time-of-flight mass spectrometry (QTOF-MS) method was firstly established to separate and identify chemical components in YPF. A total of 33 compounds were identified, including 15 constituents (flavonoids and saponins) in Astragali radix; seven constituents (sesquiterpenoids and polysaccharide) in Atractylodis rhizoma; and 11 constituents (chromone and coumarins) in Saposhnikoviae radix...
May 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28510736/go-no-go-decision-in-anaesthesia-wide-variation-in-risk-tolerance-amongst-anaesthetists
#20
P R Greig, H E Higham, J L Darbyshire, C Vincent
Background: The variability in risk tolerance in medicine is not well understood. Parallels are often drawn between aviation and anaesthesia. The aviation industry is perceived as culturally risk averse, and part of preflight checks involves a decision on whether the flight can operate. This is sometimes termed a go/no-go decision. This questionnaire study was undertaken to explore the equivalent go/no-go decision in anaesthesia. We presented anaesthetists with a range of situations in which additional risk might be expected and asked them to decide whether they would proceed with the case...
May 1, 2017: British Journal of Anaesthesia
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