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https://www.readbyqxmd.com/read/29140413/comparison-of-chemical-constituents-in-scrophulariae-radix-processed-by-different-methods-based-on-uflc-ms-combined-with-multivariate-statistical-analysis
#1
Shengnan Wang, Yujiao Hua, Lisi Zou, Xunhong Liu, Ying Yan, Hui Zhao, Yiyuan Luo, Juanxiu Liu
Scrophulariae Radix is one of the most popular traditional Chinese medicines (TCMs). Primary processing of Scrophulariae Radix is an important link which closely related to the quality of products in this TCM. The aim of this study is to explore the influence of different processing methods on chemical constituents in Scrophulariae Radix. The difference of chemical constituents in Scrophulariae Radix processed by different methods was analyzed by using ultra fast liquid chromatography-triple quadrupole-time of flight mass spectrometry coupled with principal component analysis and orthogonal partial least squares discriminant analysis...
November 13, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/29130769/neuroprotective-effects-and-uplc-q-tof-ms-based-active-components-identification-of-external-applied-a-novel-wen-luo-tong-microemulsion
#2
Hong-Mei Lin, Long-Fei Lin, Zhen-Zhen Xia, Yong Mao, Jia Liu, Ling-Yan Xu, Qing Wu
Chemotherapy induced neuropathy causes excruciating pain to cancer patients. Wen-Luo-Tong (WLT), a traditional Chinese medicinal compound, has been used to alleviate anti-cancer drug such as oxaliplatin-induced neuropathic pain for many years. However, the current route of administration of WLT is inconvenient and the active ingredients and mechanism of action of WLT are still unclear. To address these issues, we developed a novel formulation of WLT (W/O microemulsion) for the ease of application. New ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) methods were employed for analysis of the ingredients...
November 13, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29128078/applications-of-mass-cytometry-in-clinical-medicine-the-promise-and-perils-of-clinical-cytof
#3
REVIEW
Gregory K Behbehani
Mass cytometry is a novel technology similar to flow cytometry in which antibodies are tagged with heavy metal molecules rather than fluorophores and then detected with time-of-flight mass spectrometry. This enables measurement of up to 50 simultaneous parameters with no autofluorescent background and little or no spillover or required compensation. Mass cytometry has tremendous potential for the analysis of highly complex clinical samples for the diagnosis and monitoring of malignant and autoimmune disorders...
December 2017: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/29126433/mosquito-larvicidal-activity-of-cassia-tora-seed-extract-and-its-key-anthraquinones-aurantio-obtusin-and-obtusin
#4
Valentine C Mbatchou, David P Tchouassi, Rita A Dickson, Kofi Annan, Abraham Y Mensah, Isaac K Amponsah, Julia W Jacob, Xavier Cheseto, Solomon Habtemariam, Baldwyn Torto
BACKGROUND: The edible and medicinal leguminous plant Cassia tora L. (Fabaceae) is known to possess insecticidal properties against a wide range of plant-feeding insects. However, the bioactivity of extracts of this plant and their constituents against vectors of medical importance has been largely unexplored. We investigated the mosquito larvicidal activity of the seed extract and its major anthraquinones against larvae of the African malaria vector Anopheles gambiae (s.s.). METHODS: Third-fourth instar larval mortality was observed after 24, 48, 72 and 96 h of exposure to varying doses of the extracts, and two anthraquinones isolates identified using liquid chromatography- quadrupole time of flight mass spectrometry (LC-QtoF-MS)...
November 10, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29112900/serum-metabonomics-study-of-the-hepatoprotective-effect-of-amarogentin-on-ccl4-induced-liver-fibrosis-in-mice-by-gc-tof-ms-analysis
#5
Ya Zhang, Meng Zhang, Hua Li, Hang Zhao, Fang Wang, Qiaoyan He, Tian Zhang, Siwang Wang
Amarogentin (AG) is a secoiridoid glycoside that is mainly extracted from the traditional Chinese medicine Swertia and Gentiana, which have been widely used in clinical practice to treat liver disease. However, the exact hepatoprotective mechanism of AG was still looking forward to further elucidation by far. In this study, C57BL/6 mice were divided into the following three groups: control, model and AG. Fibrosis was induced by CCl4. Mice were orally treated with 100mg/kg AG or with normal saline as a control...
October 31, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29112173/chemical-fingerprint-and-multicomponent-quantitative-analysis-for-the-quality-evaluation-of-cyclocarya-paliurus-leaves-by-hplc-q-tof-ms
#6
Yanni Cao, Shengzuo Fang, Zhiqi Yin, Xiangxiang Fu, Xulan Shang, Wanxia Yang, Huimin Yang
Cyclocarya paliurus is an edible and medicinal plant containing various bioactive components with significant health benefits. A combinative method using high-performance liquid chromatography (HPLC) fingerprint and quantitative analysis was developed and successfully applied for characterization and quality evaluation of C. paliurus leaves collected from 18 geographical locations of China. For the fingerprint analysis, 21 common peaks were observed among the 18 samples, and these peaks were identified by high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF-MS), while a simultaneous quantification of 16 markers was conducted to interpret the variations of contents of these bioactive compounds among the C...
November 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29107222/comprehensive-characterization-of-the-in-vitro-and-in-vivo-metabolites-of-limonin-in-human-samples-using-lc-q-tof-ms
#7
Shijia Liu, Peidong Chen, Nongshan Zhang, Luning Sun, Guoliang Dai, Lei Zhu, Changyin Li, Yang Zhao, Li Zhang, Haiyan Fu, Wenzheng Ju
Limonin is a bitter triterpenoid dilactone in the genus Citrus with potential medicinal value. In this study, the metabolism of limonin in human was characterized by high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF-MS). A total of 7 metabolites were identified from human samples. Among them, 3 metabolites of M1, M2 and M4 were detected in urine and feces, and the others were found in intestinal bacteria sample. Notably, M1 and M3 were chemically synthesized, of which the structures were further confirmed by NMR spectra data...
October 19, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29105571/accuracy-of-pcr-targeting-different-markers-for-staphylococcus-aureus-identification-a-comparative-study-using-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-as-the-gold-standard
#8
Mauro M Saraiva, Candice M De Leon, Silvana C Santos, Danilo T Stipp, Miliane M Souza, Lauro Santos Filho, Wondwossen A Gebreyes, Celso J Oliveira
Staphylococcus aureus is considered a major pathogen in veterinary and human medicine, and the emergence of multidrug-resistant strains, such as livestock-associated methicillin-resistant S. aureus, means that reliable, inexpensive, and fast methods are required to identify S. aureus obtained from animal sources. We tested the accuracy of a PCR targeting the genes femA, nuc, and coa in identifying S. aureus from animals. A total of 157 Staphylococcus spp. isolates were examined by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry; 18 different Staphylococcus species were identified...
November 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29104669/genome-wide-association-study-for-snps-associated-with-pcos-in-human-patients
#9
Li Chen, Ling-Min Hu, Yu-Feng Wang, Hai-Yan Yang, Xiao-Yang Huang, Wei Zhou, Hai-Xiang Sun
This study investigated the possible association between single nucleotide polymorphism (SNP) sites on a genome wide level and the presence of polycystic ovary syndrome (PCOS) in a local population. Patients treated for PCOS in the outpatient clinic of the reproductive medicine center of Changzhou Maternal and Child Health Care Hospital (affiliated to Nanjing Medical University) from January of 2010 to December 2012 were selected. Female patients affected by infertility due to simple oviduct reasons or male factors, during the same period, were enrolled for the control group...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29098764/metabonomics-study-of-the-effects-of-traditional-chinese-medicine-formula-ermiaowan-on-hyperuricemic-rats
#10
Zhongbao Wei, Chen Xu, Shu Liu, Fengrui Song, Zhiqiang Liu, Xiaobo Qu
To explore the global mechanism of Ermiaowan on hyperuricemia regulation, the holistic function of Ermiaowan for hyperuricemia in rats was firstly assessed by the urinary metabonomics method which was based on ultra high performance liquid chromatography with electrospray ionization quadrupole time-of-flight mass spectrometry. The urinary targeted metabonomics approach combined with the serum biochemical analysis and histological assay was conducted to verify the research result. As a result, the significant differences in metabolic profiles were observed from Ermiaowan-treated group, model group and healthy control group by using multivariate statistical approaches...
November 3, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29097926/advanced-functional-tumor-imaging-and-precision-nuclear-medicine-enabled-by-digital-pet-technologies
#11
REVIEW
Chadwick L Wright, Katherine Binzel, Jun Zhang, Michael V Knopp
The purpose of this article is to provide a brief overview of the background, basic principles, technological evolution, clinical capabilities, and future directions for functional tumor imaging as PET evolves from the conventional photomultiplier tube-based platform into a fully digital detector acquisition platform. The recent introduction of solid-state digital photon counting PET detector is the latest evolution of clinical PET which enables faster time-of-flight timing resolution that leads to more precise localization of the annihilation events and further contributes to reduction in partial volume and thus makes high definition and ultrahigh definition PET imaging feasible with current standard acquisition procedures...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29080828/effects-of-sulfur-fumigation-on-the-pharmacokinetics-metabolites-and-analgesic-activity-of-radix-paeoniae-alba
#12
Ming Kong, Huan-Huan Liu, Jie Wu, Ming-Qin Shen, Zhi-Gang Wang, Su-Min Duan, Yan-Bo Zhang, He Zhu, Song-Lin Li
ETHNOPHARMACOLOGICAL RELEVANCE: Radix Paeoniae Alba (Baishao, BS), one of the most commonly used traditional Chinese medicinal herbs, has many pharmacological effects including analgesic activity. Previous studies found that sulfur-fumigation, a post-harvest handling process developed to prevent mold contamination of medicinal herbs, altered the quality of BS. However, whether sulfur-fumigation affects the pharmacokinetics, safety and efficacy of BS warrants further investigation. AIM OF THE STUDY: To evaluate the feasibility of sulfur-fumigation as a post-harvest handling process of BS from the viewpoints of pharmacokinetics, safety and efficacy...
October 28, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29078174/studies-on-the-chemical-and-intestinal-metabolic-profiles-of-polygalae-radix-by-using-uhplc-it-ms-n-and-uhplc-q-tof-ms-method-coupled-with-intestinal-bacteria-incubation-model-in-vitro
#13
Gui-Fang Feng, Shu Liu, Zi-Feng Pi, Feng-Rui Song, Zhi-Qiang Liu
Polygala Radix (PR) is one of the most commonly used traditional Chinese medicines (TCM), but its effective materials are still not very clear. In order to solve the existing problems, the chemical and intestinal metabolic profiles of PR were analyzed via intestinal bacteria incubation model. An integrated analysis method combined ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF MS) method and ultra-high performance liquid chromatography with ion-trap multi-stage tandem mass spectrometry (UHPLC-IT-MS(n)) method was established...
October 18, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29059576/biodegradation-of-sulfamethoxazole-in-bacteria-from-three-different-origins
#14
Sikandar I Mulla, Anyi Hu, Qian Sun, Jiagwei Li, Fidèle Suanon, Muhammad Ashfaq, Chang-Ping Yu
Sulfamethoxazole (SMX) is a common medicine prescribed to treat infections. Due to vast use, SMX has been detected in different parts of the world. Hence, it has become a high risk because of its long term persistence with high biological activity in the ecosystem. Therefore, it is necessary to understand the mechanism of SMX degradation in different genus of bacteria, which is presently unclear. In the present study, degradation of 5 mg L(-1) SMX was studied in three isolated pure bacterial cultures, Ochrobactrum sp...
October 20, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29058293/chinese-medicine-formula-shenqi-san-extract-inhibits-proliferation-of-human-lung-adenocarcinoma-a549-cells-via-inducing-apoptosis
#15
Yu Xia, Lu Shi, Zhong-Zhu Ai, De-Zhong Zhang, Yan-Wen Liu, Peng-Tao You
The main purpose of this study was to investigate the active components of the Chinese medicine formula Shenqi San (SS) by high performance liquid chromatography with diode array detector and electrospray ionization-hybrid quadrupole time-of-flight mass spectrum (HPLC-DADESI- QTOF-MS), and demonstrate the anticancer mechanism of SS on human lung adenocarcinoma A549 cells by evaluating the cell proliferation and apoptosis induction. The chloroform extraction of SS (CE-SS) was extracted from SS, while HPLC-DAD-ESI-QTOF-MS assay was performed to identify components of CE-SS...
October 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/29055030/identification-of-absorbed-constituents-and-in-vivo-metabolites-in-rats-after-oral-administration-of-physalisalkekengi-var-franchetii-by-ultrahigh-pressure-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry
#16
Xinchi Feng, Xiaoguang Huo, Hongxia Liu, Liwei Chai, Liqin Ding, Feng Qiu
The calyces of Physalisalkekengi var. franchetii (Chinese Lantern, JDL) are well-known traditional Chinese medicine owing to its various therapeutic effects. However, the bioactive constituents responsible for the pharmacological effects of JDL and their metabolites in vivo are still unclear to date. In this paper, an ultrahigh-pressure liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC/Q-TOF-MS/MS) method was established to identify absorbed constituents and in vivo metabolites in rat biological fluids after oral administration of JDL...
October 20, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29052534/specialist-advice-may-improve-patient-selection-for-decompression-therapy-following-diving-accidents-a-retrospective-observational-study
#17
Daniel Steffensmeier, Roland Albrecht, Jürg Wendling, Roger Melliger, Donat R Spahn, Philipp Stein, Christophe Wyss
BACKGROUND: Even in a landlocked country like Switzerland recreational diving is becoming more and more popular. Smaller lakes in the Alps are located at an altitude of 2500 m above sea level. The incidence of diving accidents among all helicopter emergency service missions and the consecutive medical knowledge about decompression injuries is low. Thus, a collaboration between the Swiss Air-Ambulance (Rega) and the divers alert network (DAN) was initiated to improve patient treatment and identification of decompression injury and necessity of hyperbaric oxygen therapy (HBO)...
October 19, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/29044753/development-of-a-quantitative-intracranial-vascular-features-extraction-tool-on-3d-mra-using-semiautomated-open-curve-active-contour-vessel-tracing
#18
Li Chen, Mahmud Mossa-Basha, Niranjan Balu, Gador Canton, Jie Sun, Kristi Pimentel, Thomas S Hatsukami, Jenq-Neng Hwang, Chun Yuan
PURPOSE: To develop a quantitative intracranial artery measurement technique to extract comprehensive artery features from time-of-flight MR angiography (MRA). METHODS: By semiautomatically tracing arteries based on an open-curve active contour model in a graphical user interface, 12 basic morphometric features and 16 basic intensity features for each artery were identified. Arteries were then classified as one of 24 types using prediction from a probability model...
October 17, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29040783/patient-exposure-from-nuclear-medicine-in-france-national-follow-up-and-influence-of-the-technology-through-diagnostic-reference-levels-data-analysis
#19
Patrice Roch, David Celier, Cécile Dessaud, Cécile Etard
The Nuclear Safety and Radiation Protection French Institute (IRSN) presents its latest assessment from up-to-date diagnostic reference levels (DRL) national data in nuclear medicine (NM). NM departments annually send data to IRSN to estimate the representativeness of current DRLs. Complementary analyses of the data have been performed to evaluate the influence of equipment evolution on practice and patient radiation exposure. Based on data from almost 90% of the French NM departments, some DRL update are proposed...
October 13, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29040454/to-fly-as-a-pilot-after-cardiac-surgery
#20
Thomas Syburra, Ed Nicol, Stuart Mitchell, Denis Bron, Ulrich Rosendahl, John Pepper
Aircrew are responsible for safe and reliable aircraft operations. Cardiovascular disease accounts for 50% of all pilot licences declined or withdrawn for medical reasons in Western Europe and is the most common cases of sudden incapacitation in flight. Aircrew retirement age is increasing (up to age 65) in a growing number of airlines and the burden of subclinical, but potentially significant, coronary atherosclerosis is unknown in qualified pilots above age 40. Safety considerations are paramount in aviation medicine, and the most dreaded cardiovascular complications are thromboembolic events and rhythm disturbances due to their potential for sudden incapacitation...
October 13, 2017: European Journal of Cardio-thoracic Surgery
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