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https://www.readbyqxmd.com/read/27900518/the-reconstruction-algorithm-used-for-68-ga-psma-hbed-cc-pet-ct-reconstruction-significantly-influences-the-number-of-detected-lymph-node-metastases-and-coeliac-ganglia
#1
Thomas Krohn, Anita Birmes, Oliver H Winz, Natascha I Drude, Felix M Mottaghy, Florian F Behrendt, Frederik A Verburg
PURPOSE: To investigate whether the numbers of lymph node metastases and coeliac ganglia delineated on [(68)Ga]PSMA-HBED-CC PET/CT scans differ among datasets generated using different reconstruction algorithms. METHODS: Data were constructed using the BLOB-OS-TF, BLOB-OS and 3D-RAMLA algorithms. All reconstructions were assessed by two nuclear medicine physicians for the number of pelvic/paraaortal lymph node metastases as well the number of coeliac ganglia. Standardized uptake values (SUV) were also calculated in different regions...
November 29, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27898553/the-aeromedical-physician-assistant
#2
Joshua Radi, Michael Brisson, Michael Line
The US Army aeromedical physician assistant (PA) serves aviation units in regards to crewmember medical readiness. All PAs are graduates of a 6-week flight surgeon course. They are responsible for conducting nearly 40% of the annual US Army flight physicals. This unique training and deployment illustrates the growing adaptability of PAs to assume a greater role in military medicine.
December 2016: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/27881493/the-metabolic-profiling-of-isorhamnetin-3-o-neohesperidoside-produced-by-human-intestinal-flora-employing-uplc-q-tof-ms
#3
Le-Yue Du, Min Zhao, Jin-Hua Tao, Da-Wei Qian, Shu Jiang, Er-Xin Shang, Jian-Ming Guo, Pei Liu, Shu-Lan Su, Jin-Ao Duan
Isorhamnetin-3-O-neohesperidoside is the major active substance of Puhuang, a traditional herb medicine widely used in clinical practice to tackle many chronic diseases. However, little is known about the interactions between this ingredient and intestinal flora. In this study, ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry together with automated data analysis software (Metabolynx™) was used for analysis of the metabolic profile of isorhamnetin-3-O-neohesperidoside by the isolated human intestinal bacteria...
November 23, 2016: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/27878950/comparison-of-the-chemical-profiles-of-fresh-raw-and-dry-processed-juglans-mandshurica
#4
Jinhai Huo, Xiaowei Du, Guodong Sun, Yanli Meng, Weiming Wang
The processing of Juglans mandshurica maxim. is important to reduce its toxicity and enhance its efficacy. Simple, efficient, and sensitive ultra high performance liquid chromatography coupled with a time-of-flight mass spectrometry-based chemical profiling approach was proposed to rapidly evaluate the chemical difference between fresh and dry samples. Under the optimised ultra high performance liquid chromatography and quadrupole time-of-flight tandem mass spectrometry conditions, 81 significantly different compounds were rapidly discovered using principal component analysis, and then tentatively identified by comparison with reference substances or inferred through mass spectral fragment ion analysis and literature data...
November 23, 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27874254/high-throughput-ultra-high-performance-liquid-chromatography-coupled-to-quadrupole-time-of-flight-mass-spectrometry-method-for-the-rapid-analysis-and-characterization-of-multiple-constituents-of-radix-polygalae
#5
Chang Liu, Aihua Zhang, Guang-Li Yan, Hui Shi, Hui Sun, Ying Han, Ying Zhou, Xijun Wang
Radix polygalae, the dried roots of Polygala tenuifolia and P. sibirica, is one of the most well-known traditional Chinese medicinal plants. It is an important medicinal plant that has been used as a sedative and to improve memory for a number of years in most of Asia. However, the in vivo constituents of the multiple constituents from Radix Polygalae remain unknown. In the current study, ultra high performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry and the MarkerLynx(TM) software combined with multiple data processing approach were used to study the constituents in vitro and in vivo...
November 22, 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27867266/a-new-antifungal-isocoumarin-from-the-endophytic-fungus-trichoderma-sp-09-of-myoporum-bontioides-a-gray
#6
Wensheng Li, Jiaxin Xu, Fenqi Li, Li Xu, Chunyuan Li
BACKGROUND: Myoporum bontioides A. Gray is a commonly used medicinal plant in China. Recently, the chemical and bioactive investigations to the endophytic fungi of this plant have led to several new compounds with antimicrobial and cytotoxic activities. To find out more active molecules, the metabolites of an endophytic fungus, Trichoderma sp. 09 from the root of Myoporum bontioides were investigated. MATERIALS AND METHODS: The metabolites were isolated by column chromatography on silica gel, and their structures were elucidated on the basis of spectroscopic analysis[one-dimensional (1D), two-dimensional (2D)-nuclear magnetic resonance (NMR), Mass spectrometry (MS)], and by comparison with the published data...
October 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27859774/a-metabolic-way-to-investigate-related-hurdles-caused-poor-bioavailability-in-oral-delivery-of-isoacteoside-in-rats-employing-uplc-q-tof-ms
#7
Qingling Cui, Yingni Pan, Xiaowei Yan, Bao Qu, Xiaoqiu Liu, Wei Xiao
RATIONALE: Isoacteoside (ISAT), a phenylethanoid glycoside, acting as the principal bioactive component in traditional Chinese medicines, possesses broad pharmacological effects such as neuroprotective, antihypertensive and hepatoprotective activities. However, its pharmaceutical development has been severely limited due to the poor oral bioavailability. It is essential and significant to investigate related hurdles leading to the poor bioavailability of isoacteoside. METHODS: Whole animal metabolism studies were conducted in rats, followed by metabolic mechanism including gastrointestinal stability, intestinal flora metabolism and intestinal enzyme metabolism employing the powerful ultra-high performance liquid chromatography equipped with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS)...
November 17, 2016: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/27815610/matrix-assisted-laser-desorption-ionization-imaging-mass-spectrometry-reveals-changes-of-phospholipid-distribution-in-induced-pluripotent-stem-cell-colony-differentiation
#8
Yasuo Shimizu, Motoyasu Satou, Keitaro Hayashi, Yusuke Nakamura, Mio Fujimaki, Yasuhiro Horibata, Hiromi Ando, Taiji Watanabe, Taichi Shiobara, Kazuyuki Chibana, Akihiro Takemasa, Hiroyuki Sugimoto, Naohiko Anzai, Yoshiki Ishii
Induced pluripotent stem cells (iPSCs) are opening up new possibilities for medicine. Understanding the regulation of iPSC biology is important when attempting to apply these cells to disease models or therapy. Changes of lipid metabolism in iPSCs were investigated by matrix-assisted laser desorption/ionization time-of-flight imaging mass spectrometry (MALDI-TOF-IMS). Analysis revealed changes of the intensity and distribution of peaks at m/z 782.5 and 798.5 in iPSC colonies during spontaneous differentiation...
November 4, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27801304/always-keep-your-clothes-in-the-car
#9
Curtis G Tribble
In helping to organize many different educational environments in the School of Medicine and the Department of Surgery at the University of Virginia over the last 30 years, my colleagues and I have long recognized that our students and trainees, while uniformly well prepared academically for their respective missions, often take inadequate care of themselves. Everyone who has flown on a plane will recall that the flight attendants always tell passengers that, if oxygen is needed, one must put one's own mask on first, before helping others put their masks on...
October 31, 2016: Heart Surgery Forum
https://www.readbyqxmd.com/read/27793963/can-emergency-medicine-research-benefit-from-adaptive-design-clinical-trials
#10
Laura Flight, Steven A Julious, Steve Goodacre
BACKGROUND: Adaptive design clinical trials use preplanned interim analyses to determine whether studies should be stopped or modified before recruitment is complete. Emergency medicine trials are well suited to these designs as many have a short time to primary outcome relative to the length of recruitment. We hypothesised that the majority of published emergency medicine trials have the potential to use a simple adaptive trial design. METHODS: We reviewed clinical trials published in three emergency medicine journals between January 2003 and December 2013...
October 28, 2016: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/27790826/metabolomics-method-based-on-ultra-high-performance-liquid-chromatography-with-time-of-flight-mass-spectrometry-to-analyze-toxins-in-fresh-and-dried-toad-venom
#11
Hongyue Ma, Huixia Niu, Qin Cao, Jing Zhou, Yan Gong, Zhenhua Zhu, Xiang Lv, Liuqing Di, Dawei Qian, Qinan Wu, Jin'ao Duan
Drying is a critical step to prolong the storage time in natural medicine processing but it changes the chemical characteristics of the product. In this study, the research was performed to characterize the metabolomic changes in toad venom induced by vacuum-drying at 60°C and air-drying at room temperature by ultra high performance liquid chromatography coupled with pattern recognition approaches. In total 52 metabolites, down-regulated or up-regulated, were identified as potential chemical markers. Compared with fresh toad venom, vacuum-drying at 60°C succeeded in raising the conjugated-type bufadienolide content significantly, while the content of free-type bufadienolides were slightly reduced...
October 27, 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27779958/aeromedical-evaluation-for-an-f-16-candidate-with-incomplete-paraplegia
#12
Monica Chahal-Kummen, Trond-Eirik Strand, Jan Ove Owe, Eigil Gulliksen, Anthony S Wagstaff
BACKGROUND: A candidate with paraplegia contacted the Institute of Aviation Medicine, Oslo, requesting a medical examination and medical certification for flying back seat on an F-16 Fighting Falcon. Thorough aeromedical examinations, including specialist evaluations, were initiated for the final decision to be made. CASE REPORT: Almost 13 yr earlier the candidate had acquired spinal cord damage at neurological level L1 after falling 4 m (13 ft) from out of a window...
2016: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/27778479/rapid-discovery-of-absorbed-constituents-and-metabolites-in-rat-plasma-after-the-oral-administration-of-zi-shen-wan-using-high-throughput-uhplc-ms-with-a-multivariate-analysis-approach
#13
Xian-Na Li, Aihua Zhang, Hui Sun, Yanhua Song, Di Zou, Xijun Wang
Zi Shen Wan is a typical formula consisting of three herbs, Phellodendri Amurensis Cortex, Rhizoma Anemarrhenae, and Cortex Cinnamomi, and has been widely used for treating prostatitis and infection diseases. However, it lacks in-depth research of the constituents of Zi Shen Wan in vivo and in vitro. In this work, ultra high performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry and MassLynx software was established to characterize the chemical compositions of Zi Shen Wan in vivo and in vitro...
October 24, 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27776327/component-analysis-and-target-cell-based-neuroactivity-screening-of-panax-ginseng-by-ultra-performance-liquid-chromatography-coupled-with-quadrupole-time-of-flight-mass-spectrometry
#14
Jinbin Yuan, Yang Chen, Jian Liang, Chong-Zhi Wang, Xiaofei Liu, Zhihong Yan, Yi Tang, Jiankang Li, Chun-Su Yuan
Ginseng is one of the most widely used natural medicines in the world. Recent studies have suggested Panax ginseng has a wide range of beneficial effects on aging, central nervous system disorders, and neurodegenerative diseases. However, knowledge about the specific bioactive components of ginseng is still limited. This work aimed to screen for the bioactive components in Panax ginseng that act against neurodegenerative diseases, using the target cell-based bioactivity screening method. Firstly, component analysis of Panax ginseng extracts was performed by UPLC-QTOF-MS, and a total of 54 compounds in white ginseng were characterized and identified according to the retention behaviors, accurate MW, MS characteristics, parent nucleus, aglycones, side chains, and literature data...
December 1, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27764538/comparative-evaluation-of-chemical-profiles-of-three-representative-snow-lotus-herbs-by-uplc-dad-qtof-ms-combined-with-principal-component-and-hierarchical-cluster-analyses
#15
Qi-Lei Chen, Lin Zhu, Yi-Na Tang, Hiu-Yee Kwan, Zhong-Zhen Zhao, Hu-Biao Chen, Tao Yi
Herbal healthcare products are used worldwide as relatively safe and effective alternatives to allopathic drugs. Saussurea laniceps Hand.-Mazz.(SL), S. medusa Maxim. (SM) and S. involucrata (Kar. et Kir.) Sch.Bip. (SI) are three sources of the renowned "snow lotus" Chinese Materia Medica for treating inflammatory diseases. The three species have different therapeutic effects, among which SL has been proved to be the most potent, but they are frequently confused on the market and in the academic community. An ultra-high performance liquid chromatography-diode array detector-quadrupole time of flight-mass spectrometry (UPLC-DAD-QTOF-MS) method was developed and used to analyze 49 herbal samples for species analysis and overall quality evaluation...
October 20, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27760405/rapid-identification-of-bile-acids-in-snake-bile-using-ultrahigh-performance-liquid-chromatography-with-electrospray-ionization-quadrupole-time-of-flight-tandem-mass-spectrometry
#16
Jie Zhang, Jiao Peng, Xiaoyong Chen, Yajun Gong, Lesheng Wan, Fei Gao, Suran Gan, Feng Wei, Shuangcheng Ma, Jiachun Chen, Jing Nie
Snake bile, a precious traditional Chinese medicine (TCM), was used as the major ingredient of some Chinese patent drugs, such as Shedan Chuanbei powder and Shedan Chenpi powder for hundred years. However, there is still requirement for the comprehensive and definite composition of bile acids in snake bile. In order to rapidly identify the bile acids constituents in snake bile to avoid the adulteration, ultrahigh-performance liquid chromatography with electrospray ionization quadrupole time-of-flight tandem mass spectrometry (UPLC/ESI-QTOF-MS/MS) has been applied to conduct a qualitative analysis on snake bile acids...
October 11, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27755394/clinical-evaluation-of-a-block-sequential-regularized-expectation-maximization-reconstruction-algorithm-in-18f-fdg-pet-ct-studies
#17
Bert-Ram Sah, Paul Stolzmann, Gaspar Delso, Scott D Wollenweber, Martin Hüllner, Yahya A Hakami, Marcelo A Queiroz, Felipe de Galiza Barbosa, Gustav K von Schulthess, Carsten Pietsch, Patrick Veit-Haibach
PURPOSE: To investigate the clinical performance of a block sequential regularized expectation maximization (BSREM) penalized likelihood reconstruction algorithm in oncologic PET/computed tomography (CT) studies. METHODS: A total of 410 reconstructions of 41 fluorine-18 fluorodeoxyglucose-PET/CT studies of 41 patients with a total of 2010 lesions were analyzed by two experienced nuclear medicine physicians. Images were reconstructed with BSREM (with four different β values) or ordered subset expectation maximization (OSEM) algorithm with/without time-of-flight (TOF/non-TOF) corrections...
January 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27742408/characterization-and-immunostimulating-effects-on-murine-peritoneal-macrophages-of-a-novel-protein-isolated-from-panax-quinquefolius-l
#18
Bin Qi, Shan Wang, Qiu Wang, He Zhang, Xue-Yuan Bai, Hui-Nan He, Wei-Jie Sun, Li Liu, Da-Qing Zhao
ETHNOPHARMACOLOGICAL RELEVANCE: Panax quinquefolius L. has been used as a proverbial tonic in oriental countries for hundreds of years. It is used as a traditional medicinal herb to nourish vitality. AIM OF THE STUDY: The purpose of our study was to inquiry the activation effects on murine peritoneal macrophages of a novel protein separated from the roots of Panax quinquefolius L. MATERIALS AND METHODS: In our work, a novel protein of the roots of American ginseng (AGNP) was separated and purified from the roots of Panax quinquefolius L...
October 11, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27725613/rapid-discrimination-of-closely-related-seed-herbs-cumin-caraway-and-fennel-by-direct-analysis-in-real-time-mass-spectrometry-dart-ms
#19
Borbála Antal, Ákos Kuki, Lajos Nagy, Tibor Nagy, Miklós Zsuga, Márta M-Hamvas, Gábor Vasas, Sándor Kéki
Direct analysis in real time mass spectrometry (DART-MS) was applied as a rapid method for the discrimination of the spices and traditional medicines cumin (Cuminum cyminum L.), caraway (Carum carvi L.), and fennel (Foeniculum vulgare Mill.). The seeds of these plants were analyzed without sample preparation by DART ion source coupled with quadrupole time-of-flight (QTOF) tandem mass spectrometry. The relatively clean DART spectra showed characteristic patterns, fingerprints, for each herb. It was found that a marker compound can be assigned to each species that can identify unambiguously these plants...
2016: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/27721071/dereplication-guided-isolation-of-novel-hepatoprotective-triterpenoid-saponins-from-celosiae-semen-by-high-performance-liquid-chromatography-coupled-with-electrospray-ionization-tandem-quadrupole-time-of-flight-mass-spectrometry
#20
Yan Jiang, Feng-Jie Liu, Yu-Mei Wang, Hui-Jun Li
Although natural products (NPs) from ethnomedical plants have played a vital role in modern drug discovery, separation and purification of bioactive compounds from plant extract is still challenging. In this study, a dereplication strategy using HPLC-QTOF-MS was employed to rapidly discover and highly targeted isolate the novel hepatoprotective triterpenoid saponins from the methanol extract of Celosiae Semen. Firstly, four known saponins, i.e. celosin H, celosin I, celosin J, and pseudoginsenoside RT1 were selected as model compounds, and their fragmentation patterns in ESI-QTOF-MS/MS were characterized...
October 3, 2016: Journal of Pharmaceutical and Biomedical Analysis
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