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https://www.readbyqxmd.com/read/28226975/portable-forced-oscillation-device-for-point-of-care-pulmonary-function-testing
#1
Jian Cao, Ashutosh Sabharwal, Jian Cao, Ashutosh Sabharwal, Jian Cao, Ashutosh Sabharwal
The forced oscillation technique (FOT) provides a simple and accurate approach for pulmonary function testing. However, most current devices are large and high cost, hence the test remains sparingly used. To address this problem, we verified the feasibility of a smart and portable forced oscillation device based on a small subwoofer and ultrasonic sensor that is targeted at point-of-care pulmonary function testing. In this paper, we first develop and optimize the signal processing algorithm for impedance estimation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226639/an-initial-investigation-into-the-real-time-conversion-of-facial-surface-emg-signals-to-audible-speech
#2
Lorenz Diener, Christian Herff, Matthias Janke, Tanja Schultz, Lorenz Diener, Christian Herff, Matthias Janke, Tanja Schultz, Lorenz Diener, Christian Herff, Matthias Janke, Tanja Schultz
This paper presents early-stage results of our investigations into the direct conversion of facial surface electromyographic (EMG) signals into audible speech in a real-time setting, enabling novel avenues for research and system improvement through real-time feedback. The system uses a pipeline approach to enable online acquisition of EMG data, extraction of EMG features, mapping of EMG features to audio features, synthesis of audio waveforms from audio features and output of the audio waveforms via speakers or headphones...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28219983/neural-representation-and-causal-models-in-motor-cortex
#3
Kris S Chaisanguanthum, Helen H Shen, Philip N Sabes
Dorsal premotor (PMd) and primary motor (M1) cortex play a central role in mapping sensation to movement. Many studies of these areas have focused on correlation-based tuning curves relating neural activity to task or movement parameters, but the link between tuning and movement generation is unclear. We recorded motor preparatory activity from populations of neurons in PMd/M1 as macaque monkeys performed a visually guided reaching task and show that tuning curves for sensory inputs (reach target direction) and motor outputs (initial movement direction) are not typically aligned...
February 20, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28212092/modeling-contrast-imaging-assisted-optimal-targeted-drug-delivery-a-touchable-communication-channel-estimation-and-waveform-design-perspective
#4
Yifan Chen, Yu Zhou, Ross Murch, Panagiotis Kosmas
To maximize the effect of treatment and minimize the adverse effect on patients, we propose to optimize nanorobotsassisted targeted drug delivery (TDD) for locoregional treatment of tumor from the perspective of touchable communication channel estimation and waveform design. The drug particles are the information molecules; the loading/injection and unloading of the drug correspond to the transmitting and receiving processes; the concentration-time profile of the drug particles administered corresponds to the signalling pulse...
February 15, 2017: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/28210059/the-validity-of-an-accelerometer-based-method-for-estimating-fluidity-in-the-sit-to-walk-task-in-a-community-setting
#5
Tomoyuki Asakura, Yoshiyuki Miyazawa, Shigeru Usuda
[Purpose] Fluidity in the sit-to-walk task has been quantitatively measured with three-dimensional motion analysis system. The purpose of this study was to determine the validity of an accelerometer-based method for estimating fluidity in community-dwelling elderly individuals. [Subjects and Methods] Seventeen community-dwelling elderly females performed a sit-to-walk task. The motion was recorded by an accelerometer, a three-dimensional motion analysis system and a foot pressure sensor simultaneously. The timings of events determined from the acceleration waveform were compared to the timings determined from the three-dimensional motion analysis data (task onset, maximum trunk inclination) or foot pressure sensor data (first heel strike)...
January 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28202586/waveform-sensitivity-of-electroreceptors-in-the-pulse-weakly-electric-fish-gymnotus-omarorum
#6
Alejo Rodríguez-Cattaneo, Pedro A Aguilera, Angel A Caputi
As in most sensory systems electrosensory images in weakly electric fish are encoded in two parallel pathways, fast and slow. From the work on wave type electric fish these pathways are thought to encode the time and amplitude of electrosensory signals respectively. This article focuses on the primary afferents giving origin to the slow path of the pulse type weakly electric fish Gymnotus omarorum We found that burst duration coders respond with a high-frequency train of spikes to each electric organ discharge...
February 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28198871/generating-high-contrast-near-single-cycle-waveforms-with-third-order-dispersion-compensation
#7
Henry Timmers, Yuki Kobayashi, Kristina F Chang, Maurizio Reduzzi, Daniel M Neumark, Stephen R Leone
Femtosecond laser pulses lasting only a few optical periods hold the potential for probing and manipulating the electronic degrees of freedom within matter. However, the generation of high-contrast, few-cycle pulses in the high power limit still remains nontrivial. In this Letter, we present the application of ammonium dihydrogen phosphate (ADP) as an optical medium for compensating for the higher-order dispersion of a carrier-envelope stable few-cycle waveform centered at 735 nm. The ADP crystal is capable of removing the residual third-order dispersion present in the spectral phase of an input pulse, resulting in near-transform-limited 2...
February 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28163537/qtc-interval-in-young-gujarati-hypertensives-effect-of-disease-antihypertensive-monotherapy-and-coexisting-risk-factors
#8
Jayesh Dalpatbhai Solanki, Bhakti P Gadhavi, Amit H Makwana, Hemant B Mehta, Chinmay J Shah, Pradnya A Gokhale
OBJECTIVES: To study the effect of disease duration, treatment and risk factors on QTc interval among young hypertensives. MATERIALS AND METHODS: A case-control study was conducted on 142 hypertensives (60 males, 82 females) taking calcium channel blocker (CCB) or angiotensin-converting enzyme inhibitor (ACEI) as monotherapy. After blood pressure measurement, we recorded lead II electrocardiograph with minimum ten waveforms. QTc was derived from average of ten values using Bazett's formula...
October 2016: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/28163191/csahi-study-detection-of-drug-induced-ion-channel-receptor-responses-qt-prolongation-and-arrhythmia-using-multi-electrode-arrays-in-combination-with-human-induced-pluripotent-stem-cell-derived-cardiomyocytes
#9
Takashi Kitaguchi, Yuta Moriyama, Tomohiko Taniguchi, Sanae Maeda, Hiroyuki Ando, Takaaki Uda, Koji Otabe, Masao Oguchi, Shigekazu Shimizu, Hiroyuki Saito, Atsushi Toratani, Mahoko Asayama, Wataru Yamamoto, Emi Matsumoto, Daisuke Saji, Hiroki Ohnaka, Norimasa Miyamoto
INTRODUCTION: The use of multi-electrode arrays (MEA) in combination with human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) provides a promising method to predict comprehensive cardiotoxicity, including drug-induced QT prolongation and arrhythmia. We previously demonstrated that MEA in combination with hiPSC-CMs could provide a generalizable platform by using 7 reference drugs at 10 testing facilities. Using this approach, we evaluated responses to reference drugs that modulate a range of cardiac ion currents and have a range of arrhythmogenic effects...
February 2, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/28157430/factors-determining-in-vitro-lung-deposition-of-albuterol-aerosol-delivered-by-ventolin-metered-dose-inhaler
#10
Rajoshi Biswas, Nicola A Hanania, Ashutosh Sabharwal
BACKGROUND: The effectiveness of metered-dose inhalers (MDIs) in delivering medication to the lungs highly depends on its correct usage technique. Current guidelines state optimal technique for high lung deposition should include a slow inhalation (>5 seconds) at an inspiratory flow rate of 30 L/min and inhaler actuation at the start of inhalation. However, these recommendations were based on clinical studies using CFC (chlorofluorocarbon)-MDIs and in vitro studies of HFA (hydrofluoroalkane)-MDIs using idealized MDI techniques of uniform inhalation and actuation, disregarding the nonuniform techniques of actual patients...
February 3, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/28147660/an-integrated-device-with-high-performance-multi-function-generators-and-time-to-digital-convertors
#11
X Qin, Z Shi, Y Xie, L Wang, X Rong, W Jia, W Zhang, J Du
A highly integrated, high performance, and re-configurable device, which is designed for the Nitrogen-Vacancy (N-V) center based quantum applications, is reported. The digital compartment of the device is fully implemented in a Field-Programmable-Gate-Array (FPGA). The digital compartment is designed to manage the multi-function digital waveform generation and the time-to-digital convertors. The device provides two arbitrary-waveform-generator channels which operate at a 1 Gsps sampling rate with a maximum bandwidth of 500 MHz...
January 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28129427/the-effect-of-gaze-angle-on-visual-acuity-in-infantile-nystagmus
#12
Matt J Dunn, Debbie Wiggins, J Margaret Woodhouse, Tom H Margrain, Christopher M Harris, Jonathan T Erichsen
Purpose: Most individuals with infantile nystagmus (IN) have an idiosyncratic gaze angle at which their nystagmus intensity is minimized. Some adopt an abnormal head posture to use this "null zone," and it has therefore long been assumed that this provides people with nystagmus with improved visual acuity (VA). However, recent studies suggest that improving the nystagmus waveform could have little, if any, influence on VA; that is, VA is fundamentally limited in IN. Here, we examined the impact of the null zone on VA...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28126373/mixed-xylem-and-phloem-sap-ingestion-in-sheath-feeders-as-normal-dietary-behavior-evidence-from-the-leafhopper-scaphoideus-titanus
#13
Julien Chuche, Nicolas Sauvion, Denis Thiery
In phytophagous piercing-sucking insects, salivary sheath-feeding species are often described as xylem- or phloem-sap feeding specialists. Because these two food sources have very different characteristics, two feeding tactics are often associated with this supposed specialization. Studying the feeding behavior of insects provides substantial information on their biology, ecology, and evolution. Furthermore, study of feeding behavior is of primary importance to elucidate the transmission ability of insects that act as vectors of plant pathogens...
January 23, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/28114611/characterization-of-vocal-fold-vibration-in-sulcus-vocalis-using-high-speed-digital-imaging
#14
Akihito Yamauchi, Hisayuki Yokonishi, Hiroshi Imagawa, Ken-Ichi Sakakibara, Takaharu Nito, Niro Tayama, Tatsuya Yamasoba
Purpose: The aim of the present study was to qualitatively and quantitatively characterize vocal fold vibrations in sulcus vocalis by high-speed digital imaging (HSDI) and to clarify the correlations between HSDI-derived parameters and traditional vocal parameters. Method: HSDI was performed in 20 vocally healthy subjects (8 men and 12 women) and 41 patients with sulcus vocalis (33 men and 8 women). Then HSDI data were evaluated by assessing the visual-perceptual rating, digital kymography, and glottal area waveform...
January 1, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28114042/validation-of-an-adaptive-transfer-function-method-to-estimate-the-aortic-pressure-waveform
#15
Yang Yao, Lisheng Xu, Yingxian Sun, Qiang Fu, Shuran Zhou, Dianning He, Yahui Zhang, Liang Guo, Dingchang Zheng
Aortic pulse wave reflects cardiovascular status, but unlike the peripheral pulse wave, is difficult to be measured reliably using non-invasive techniques. Thus, the estimation of aortic pulse wave from peripheral ones is of great significance. This study proposed an adaptive transfer function (ATF) method to estimate the aortic pulse wave from the brachial pulse wave. Aortic and brachial pulse waves were derived from 26 patients who underwent cardiac catheterization. Generalized transfer functions (GTF) were derived based on the autoregressive exogenous model...
December 6, 2016: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28113861/in-vivo-magnetic-stimulation-of-rat-sciatic-nerve-with-centimeter-and-millimeter-scale-solenoid-coils
#16
Zachary Kagan, Anil RamRakhyani, Gianluca Lazzi, Richard Normann, David Warren
Previous reports of magnetic stimulation of the peripheral nervous system (PNS) used various coil geometries, all with outer diameters larger than 35 mm, and stimulation energies in the 50 J range to evoke neural excitation. Recent reports of central nervous system (CNS) activation used sub-mm-scale solenoid coils with mJ energy levels. The goal of this study was to translate the lower energy levels from the CNS to the PNS via using smaller coils placed in closer proximity to the neural tissue. Such a performance improvement would advance the state of the art of magnetic stimulation and provide a path towards new neuroprosthetic devices...
March 21, 2016: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28107074/analysis-of-the-normal-electrocardiogram-in-wild-rooks-corvus-frugilegus
#17
Hossein Hassanpour, Hossein Abbasi Dehkordi, Mehdi Khosravi, Saeid Soltani, Leila Nasiri
To describe the normal electrocardiographic (ECG) patterns and values in unanesthetized rooks ( Corvus frugilegus ), standard bipolar (I, II, and III) and augmented unipolar limb (aVR, aVL, and aVF) lead ECGs were recorded from 10 clinically healthy wild rooks. Wave forms were analyzed in all leads at 50 mm/s and at 10 mm = 1 mV to determine PR, QRS, ST, and QT durations; the net QRS complex; and P and T amplitudes. The polarity of each waveform was tabulated in all leads. The mean electrical axis (MEA) for the frontal plane was counted by using leads II and III...
December 2016: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/28102355/determining-arterial-wave-transit-time-from-a-single-aortic-pressure-pulse-in-rats-vascular-impulse-response-analysis
#18
Ru-Wen Chang, Chun-Yi Chang, Liang-Chuan Lai, Ming-Shiou Wu, Tai-Horng Young, Yih-Sharng Chen, Chih-Hsien Wang, Kuo-Chu Chang
Arterial wave transit time (τw) in the lower body circulation is an effective biomarker of cardiovascular risk that substantially affects systolic workload imposed on the heart. This study evaluated a method for determining τw from the vascular impulse response on the basis of the measured aortic pressure and an assumed triangular flow (Q(tri)). The base of the unknown Q(tri) was constructed with a duration set equal to ejection time. The timing of the peak triangle was derived using a fourth-order derivative of the pressure waveform...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28097733/optimized-amplitude-modulated-multiband-rf-pulse-design
#19
Samy Abo Seada, Anthony N Price, Joseph V Hajnal, Shaihan J Malik
PURPOSE: Multiband pulses are characterized by highly temporally modulated waveforms. Rapid phase or frequency modulation can be extremely demanding on the performance of radiofrequency (RF) pulse generation, which can lead to errors that can be avoided if pulses are restricted to amplitude modulation (AM) only. In this work, three existing multiband pulse design techniques are modified to produce AM waveforms. THEORY AND METHODS: Multiband refocusing pulses were designed using phase optimization, time shifting, and root flipping...
January 17, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28097009/statin-utilisation-in-a-real-world-setting-a-retrospective-analysis-in-relation-to-arterial-and-cardiovascular-autonomic-function
#20
John D Sluyter, Alun D Hughes, Andrew Lowe, Carlos A Camargo, Robert K R Scragg
Randomized trials suggest that statin treatment may lower blood pressure and influence cardiovascular autonomic function (CVAF), but the impact of duration of usage, discontinuation, and adherence to this therapy is unknown. We examined these issues with regard to blood pressure (BP)-related variables in a large, population-based study. Participants were 4942 adults (58% male; aged 50-84 years): 2179 on statin treatment and 2763 untreated. Days of utilization, adherence (proportion of days covered ≥0.8), and discontinuation (non-use for ≥30 days immediately prior to BP measurement) of three statins (atorvastatin, pravastatin, and simvastatin) over a period of up to 2 years was monitored retrospectively from electronic databases...
December 2016: Pharmacology Research & Perspectives
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