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Y L Cao, W Li
Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) which represented a new two-steps liver resection procedures has been considered a revolutionary innovation for liver surgery technique in recent 10 years, it was first discovered by Professor Lang in Germany in 2007.The first step of the classic surgical procedures for portal vein ligation and liver parenchyma, until the future liver remnant (FLR) increased to a sufficient remnant then resect the right three-leaf liver.With the development of ALPPS, the method of hepatic parenchyma separation and isolation materials have been modified, which improves the safety of operation...
April 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
Veronica Mendoza-Reinoso, Annemiek Beverdam
The skin constantly self-renews throughout adult life. Wnt/β-catenin signaling plays a key role in promoting keratinocyte proliferation in the hair follicles and in the interfollicular epidermis. A recent report demonstrated that epidermal YAP activity drives β-catenin activation to promote keratinocyte proliferation in the murine skin. However, it remains unclear whether this is caused by paracrine activation of canonical Wnt signaling or through other YAP/β-catenin regulatory interactions. In the present study, we found that XAV939-inhibition of canonical WNT signaling in skin of YAP2-5SA-ΔC mice resulted in diminished β-catenin activation, reduced keratinocyte proliferation, and a mitigation of the hyperplastic abnormalities in the interfollicular epidermis, signifying a canonical WNT ligand-dependent mechanism...
March 10, 2018: Stem Cell Research
Ali Arjmandi, Hamid Reza Zare-Mehrjardi, Hadi Kargar
In this work, the carbon paste electrode (CPE) was modified using the cis-dioxo-bis[3-methoxy-2,2-dimethylpropanediamine] molybdenum(VI) complex and 1-octanaminium,N,N,N-trioctyl bromide. Using the modified electrode, the best separation of anodic peaks for ascorbic acid and dopamine was obtained in solutions with pH 5.0 and the linear range for ascorbic acid is acquired in the range from 3.0 × 10-6 to 6.0 × 10-3 M and for dopamine from 2.0 × 10-6 to 1.0 × 10-2 M. The limits of detection (S/N = 3) were 4 × 10-7 M and 5 × 10-7 M for dopamine and ascorbic acid, respectively...
March 2018: Acta Chimica Slovenica
Feng Liang, Christian Giordano, Dong Shang, Qian Li, Basil J Petrof
Duchenne muscular dystrophy (DMD) is characterized by progressive muscle weakness which is ultimately fatal, most often due to involvement of the diaphragm. Macrophage infiltration of dystrophic muscles has been strongly linked to muscle damage and fibrosis in DMD. We hypothesized that cenicriviroc (CVC), a dual chemokine receptor (CCR2/CCR5) antagonist currently under clinical evaluation for other diseases, could prevent macrophage accumulation and blunt disease progression in the diaphragms of mdx mice (genetic homologue of DMD)...
2018: PloS One
Óscar M Chaves, Júlio César Bicca-Marques, Colin A Chapman
Seed dispersal is a key process driving the structure, composition, and regeneration of tropical forests. Larger frugivores play a crucial role in community structuring by dispersing large seeds not dispersed by smaller frugivores. We assessed the hypothesis that brown howler monkeys (Alouatta guariba clamitans) provide seed dispersal services for a wide assemblage of plant species in both small and large Atlantic forest fragments. Although fruit availability often decreases in small fragments compared with large ones, we predicted that brown howlers are efficient seed dispersers in quantitative and qualitative terms in both forest types given their high dietary flexibility...
2018: PloS One
Yang Wei, Yu-Han Chang, Chung-Jui Liu, Ren-Jei Chung
The susceptibility of guided bone regeneration (GBR) material to infection by pathogens at wound sites during bone healing has often been overlooked. The objective of this study was the synthesis and characterization of a potential material for antibacterial GBR application. In the current study, the mechanical strength and biocompatibility of a composite restoration material-made of oxidized hyaluronic acid (HA)/type I collagen hydrogel integrated with tricalcium phosphate (β-TCP) using a natural crosslinking agent, oligomeric proanthocyanidins (OPCs)-were evaluated...
March 21, 2018: Pharmaceutics
Zhuoyue Chen, Zhen Zhang, Juantao Feng, Yayuan Guo, Yuan Yu, Jihong Cui, Hongmin Li, Lijun Shang
One of the key challenges in bone healing and regeneration is the implant with osteoinductive activity. Therapeutic application of recombinant human bone morphogenetic protein-2 (rhBMP-2) is a promising approach to enhance osteogenesis. However, high dose and uncontrolled burst in the release kinetics of BMP-2 may introduce oedema, bone overgrowth, cyst-like bone formation and significant inflammation. In this study, low dose BMP-2 of 1µg was used to design PLA-PD-BMP for functionalization of polylactic acid (PLA) implants via mussel-inspired polydopamine (PD) assist...
March 21, 2018: ACS Applied Materials & Interfaces
Francesco Mangano, Alberta Greco Lucchina, Matteo Brucoli, Mario Migliario, Carmen Mortellaro, Carlo Mangano
PURPOSE: To evaluate the long-term cumulative implant survival rate (CISR%) and cumulative implant-crown success rate (CICSR%) of single-tooth Morse-taper connection implants, with particular attention to documenting the incidence of prosthetic complications. METHODS: The customized records of all patients who had been treated with single-tooth Morse-taper connection implants in 2 dental centers during the period between January 2002 and December 2012 were revisited...
March 20, 2018: Journal of Craniofacial Surgery
Xiaowei Wu, Shang Zheng, Yuanzhou Ye, Yuchen Wu, Kaili Lin, Jiansheng Su
The reconstruction of bone defects by guiding autologous bone tissue regeneration with artificial biomaterials is a potential strategy in the area of bone tissue engineering. The development of new polymers with good biocompatibility, favorable mechanical properties, and osteoinductivity is of vital importance. Graphene and its derivatives have attracted extensive interests due to the exceptional physiochemical and biological properties of graphene. In this study, poly(lactic-co-glycolic acid) (PLGA) films incorporated by graphene nanoplates were fabricated...
March 21, 2018: Biomaterials Science
B L Farrugia, M S Lord, J M Whitelock, J Melrose
The development of bioscaffolds that incorporate chondroitin sulphate (CS) and their applications with progenitor and stem cells in cartilage, bone, cornea, skin, and neural repair are reviewed. CS is a heterogeneous structure due to the organisation of multiple CS disaccharide sulphation motifs, giving rise to a vast range of CS chain structures, and hence the wide range of biological activity. The incorporation of this biological molecule represents a significant advance in bioscaffold design and performance in tissue repair strategies...
March 21, 2018: Biomaterials Science
Fang-Yu Liu, Te-Cheng Hsu, Patrick Choong, Min-Hsuan Lin, Yung-Jen Chuang, Bor-Sen Chen, Che Lin
BACKGROUND: Regeneration is an important biological process for the restoration of organ mass, structure, and function after damage, and involves complex bio-physiological mechanisms including cell differentiation and immune responses. We constructed four regenerative protein-protein interaction (PPI) networks using dynamic models and AIC (Akaike's Information Criterion), based on time-course microarray data from the regeneration of four zebrafish organs: heart, cerebellum, fin, and retina...
March 19, 2018: BMC Systems Biology
Jinbin Liu, Jing Jiang, Yajun Bai, Tai-Ping Fan, Ye Zhao, Xiaohui Zheng, Yujie Cai
Bacteria rarely produce natural 2-phenylethanol. We verified a new pathway from Proteus mirabilis JN458 to produce 2-phenylethanol using Escherichia coli to co-express L-amino acid deaminase, α-keto acid decarboxylase, and alcohol dehydrogenase from P. mirabilis. Based on this pathway, a glucose dehydrogenase coenzyme regeneration system was constructed. The optimal conditions of biotransformation by the recombinant strain E-pAEAKaG were at 40°C and pH 7.0. Finally, the recombinant strain E-pAEAKaG produced 3...
March 21, 2018: Journal of Agricultural and Food Chemistry
Chang Ho Yoon, Daeseung Lee, Hyun Jeong Jeong, Jin Suk Ryu, Mee Kum Kim
PURPOSE: Interleukin (IL)-22 is a cytokine involved in epithelial cell regeneration. Currently, no research studies have analyzed the distribution of the three distinct IL-22-secreting cell populations in human or mouse conjunctiva. This study investigated the distribution of the three main populations of IL-22-secreting immune cells, αβ Th cells, γδ T cells, or innate cells (innate lymphoid cells [ILCs] or natural killer cells), in conjunctival associated lymphoid tissues (CALTs) in human and mouse models...
March 19, 2018: Korean Journal of Ophthalmology: KJO
Jianguo Wang, Nan Chen, Chuanping Feng, Miao Li
To obtain an economical and effective adsorbent for fluoride removal, lanthanum-loaded pomelo peel biochar (PPBC-La) was synthesized using a facile approach. The batch adsorption experiments were investigated to determine adsorbent performance. The PPBC-La and its pristine biochar (PPBC) were characterized by scanning electronic microscopy (SEM), zeta potential, Brunauer-Emmett-Teller (BET), Fourier transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS) methods. Experimental results showed that the adsorption data were described well by the pseudo-second-order kinetic and Freundlich isotherm models...
March 21, 2018: Environmental Science and Pollution Research International
Sarah E Motta, Emanuela S Fioretta, Petra E Dijkman, Valentina Lintas, Luc Behr, Simon P Hoerstrup, Maximilian Y Emmert
Tissue-engineered heart valves with self-repair and regeneration properties may overcome the problem of long-term degeneration of currently used artificial prostheses. The aim of this study was the development and in vivo proof-of-concept of next-generation off-the-shelf tissue-engineered sinus valve (TESV) for transcatheter pulmonary valve replacement (TPVR). Transcatheter implantation of off-the-shelf TESVs was performed in a translational sheep model for up to 16 weeks. Transapical delivery of TESVs was successful and showed good acute and short-term performance (up to 8 weeks), which then worsened over time most likely due to a non-optimized in vitro valve design...
March 20, 2018: Journal of Cardiovascular Translational Research
Giuseppe Cardellini, Tatiana Valada, Claire Cornillier, Estelle Vial, Marian Dragoi, Venceslas Goudiaby, Volker Mues, Bruno Lasserre, Arkadiusz Gruchala, Per Kristian Rørstad, Mathias Neumann, Miroslav Svoboda, Risto Sirgmets, Olli-Pekka Näsärö, Frits Mohren, Wouter M J Achten, Liesbet Vranken, Bart Muys
Life cycle assessment (LCA) has become a common methodology to analyze environmental impacts of forestry systems. Although LCA has been widely applied to forestry since the 90s, the LCAs are still often based on generic Life Cycle Inventory (LCI). With the purpose of improving LCA practices in the forestry sector, we developed a European Life Cycle Inventory of Forestry Operations (EFO-LCI) and analyzed the available information to check if within the European forestry sector national differences really exist...
March 20, 2018: Environmental Management
Lara Bieler, Lukas Grassner, Pia Zaunmair, Christina Kreutzer, Lukas Lampe, Eugen Trinka, Julia Marschallinger, Ludwig Aigner, Sebastien Couillard-Despres
Following spinal cord injury, severe deficits result from damages to ascending and descending tracts, such as the corticospinal tract (CST) which is highly relevant for the motor execution in humans. Unfortunately, no curative treatment is available and intensive efforts are deployed in animal models, such as the CST transection model, to identify interventions providing functional regeneration after spinal cord injury. The CatWalk XT is a system for multi-parameter gait analysis of voluntary locomotion. In this study, the performance of the CatWalk XT for monitoring of functional deficits associated with dorsal CST lesion in rats was compared to skilled locomotion tests...
February 2018: Heliyon
Joao N A Ferreira, Changyu Zheng, Isabelle M A Lombaert, Corinne M Goldsmith, Ana P Cotrim, Jennifer M Symonds, Vaishali N Patel, Matthew P Hoffman
Head and neck cancer patients treated with irradiation often present irreversible salivary gland hypofunction for which no conventional treatment exists. We recently showed that recombinant neurturin, a neurotrophic factor, improves epithelial regeneration of mouse salivary glands in ex vivo culture after irradiation by reducing apoptosis of parasympathetic neurons. Parasympathetic innervation is essential to maintain progenitor cells during gland development and for regeneration of adult glands. Here, we investigated whether a neurturin-expressing adenovirus could be used for gene therapy in vivo to protect parasympathetic neurons and prevent gland hypofunction after irradiation...
June 15, 2018: Molecular Therapy. Methods & Clinical Development
Brian B Silver, Celeste M Nelson
Cancer is a complex, heterogeneous group of diseases that can develop through many routes. Broad treatments such as chemotherapy destroy healthy cells in addition to cancerous ones, but more refined strategies that target specific pathways are usually only effective for a limited number of cancer types. This is largely due to the multitude of physiological variables that differ between cells and their surroundings. It is therefore important to understand how nature coordinates these variables into concerted regulation of growth at the tissue scale...
2018: Frontiers in Cell and Developmental Biology
Michael Karsy, Cheryl A Palmer, Mark A Mahan
BACKGROUND: Laminins are extracellular matrix proteins that participate in endoneurial tubule formation and are important in the regeneration of nerves after injury. They act as scaffolds to guide nerves to distal targets and play a key role in neurite outgrowth. Because there is evidence that laminin architecture affects nerve regeneration, we evaluated endoneurial tubules by examining the laminin structure in clinical samples from patients with nerve injuries. METHODS: In a retrospective review of eight nerve injury cases, we evaluated nerve histology in relation to clinical history and injury type...
January 18, 2018: Curēus
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