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https://www.readbyqxmd.com/read/28945013/pro-regenerative-hydrogel-restores-scarless-skin-during-cutaneous-wound-healing
#1
Guoming Sun
The transformation of fibrotic healing process to regenerative one has great potential to fully restore wounded skin. The M2 macrophage phenotype promotes constructive tissue remodeling and instructs tissue repair in a regenerative manner. It is hypothesized that hydrogels that can establish robustness of endogenous cells to regulate M2 phenotype will promote constructive dermal remodeling. Toward this end, a series of dextran-based bioabsorbable hydrogels are developed and self-crosslinkable dextran-isocyanatoethyl methacrylate-ethylamine (DexIEME) is identified as the potential scaffold...
September 25, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28944869/promoting-potential-of-adipose-derived-stem-cells-on-peripheral-nerve-regeneration
#2
Jiayan Guo, Shu Guo, Yuxin Wang, Yanqiu Yu
The ultimate goal of treating peripheral nerve defects is reconstructing continuity of the nerve stumps to regain nerve conduction and functional recovery. Clinically, autologous nerve grafts and Schwann cell (SC) therapy have limitations, such as the need for secondary surgery, sacrifice of another nerve and donor site complication. Adipose derived stem cells (ADSCs) may promise to be ideal alternative cells of SCs. To explore the potential of ADSCs promoting peripheral nerve regeneration, the present study investigated the influences of ADSCs on proliferation and neurotrophic function of SCs using co‑culture model in vitro...
September 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944860/polyaniline-promotes-peripheral-nerve-regeneration-by-enhancement-of-the-brain%C3%A2-derived-neurotrophic-factor-and-ciliary-neurotrophic-factor-expression-and-activation-of-the-erk1-2-mapk-signaling-pathway
#3
Lin Fan, Yan Xiong, Zhen Fu, Dingfeng Xu, Lei Wang, Yong Chen, Haoyang Xia, Na Peng, Shaojun Ye, Yanfeng Wang, Lina Zhang, Qifa Ye
A previous study has demonstrated a progression in the nerve regeneration by polyaniline/cellulose (PANI/RC), although the underlying mechanism was not elucidated. In the present study, regenerated nerves were investigated, using histological techniques, functional assays and western blot analysis. The triceps surae muscle weight ratio percentages of the sham, regenerated cellulose (RC) and the PANI/RC groups were 38.88±4.76 and 76.32±7.11%, respectively. The thickness of the myelin sheath for the aforementioned groups were as follows: 1...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944834/nf%C3%A2-%C3%AE%C2%BAb%C3%A2-mir15a%C3%A2-bfgf-vegfa-axis-contributes-to-the-impaired-angiogenic-capacity-of-bm%C3%A2-mscs-in-high-fat-diet%C3%A2-fed-mice
#4
Zhuoli Zhu, Xueqi Gan, Haiyang Yu
Potent paracrine properties, such as secretion of angiogenic cytokines and growth factors, have been considered essential for the function of mesenchymal stem cells (MSCs) in tissue regeneration and repair. The present study determined that bone marrow‑derived mesenchymal stem cells from mice fed a high fat diet (HFD) had reduced pro‑angiogenic capacity, as evident from the reduced expression of vascular endothelial growth factor A (VEGFA) and basic fibroblast growth factor (bFGF); therefore, a reduced number of branches was induced in the angiogenesis assay...
September 18, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944821/transplantation-of-periodontal-ligament-cell-sheets-expressing-human-%C3%AE-%C3%A2-defensin%C3%A2-3-promotes-anti%C3%A2-inflammation-in-a-canine-model-of-periodontitis
#5
Minwen Zhu, Bo Miao, Jianhua Zhu, Haiyan Wang, Zengtong Zhou
Periodontitis is a chronic oral inflammatory disease caused by microorganisms. Human β‑defensin‑3 (HBD‑3) is an endogenous antimicrobial peptide that inhibits a broad spectrum of microorganisms. Cell sheet technology has been widely applied in tissue and organ reconstructions. In the current study, it was aimed to investigate the anti‑inflammatory effect of periodontal tissue engineered by HBD‑3 gene‑modified periodontal ligament cell (PDLC) sheets, and to identify a suitable method of promoting the regeneration of periodontal tissues...
September 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944762/a-cell-laden-hybrid-fiber-hydrogel-composite-for-ligament-regeneration-with-improved-cell-delivery-and-infiltration
#6
Jeong Hwa Kim, Yeong-Jin Choi, Hee-Gyeong Yi, Joon Ho Wang, Dong-Woo Cho, Young Hun Jeong
Ligament, a fibrous connective tissue between bones, is a unique tissue in human anatomy because it has complex viscoelastic properties and is very tough. Moreover, it is an important tissue for regeneration because frequent injuries occur, but there are limited types of substitutes that can be used as a tissue replacement. In this study, we present a stem cell-laden fiber/hydrogel composite structure with a layered fibrous structure, which can enhance cell infiltration, topographical cue and mechanical properties...
September 25, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28944711/a-hybrid-composite-system-of-biphasic-calcium-phosphate-granules-loaded-with-hyaluronic-acid-gelatin-hydrogel-for-bone-regeneration
#7
Omar Faruq, Boram Kim, Andrew R Padalhin, Gun Hee Lee, Byong-Taek Lee
An ideal bone substitute should be made of biocompatible materials that mimic the structure, characteristics, and functions of natural bone. Many researchers have worked on the fabrication of different bone scaffold systems including ceramic-polymer hybrid system. In the present study, we incorporated hyaluronic acid-gelatin hydrogel to micro-channeled biphasic calcium phosphate granules as a carrier to improve cell attachment and proliferation through highly interconnected porous structure. This hybrid system is composed of ceramic biphasic calcium phosphate granules measuring 1 mm in diameter with seven holes and hyaluronic acid-gelatin hydrogel...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28944671/prioritizing-popular-proteins-in-liver-cancer-remodelling-one-carbon-metabolism
#8
María Isabel Mora, Manuela Molina, Leticia Odriozola, Felix Elortza, Jose M Mato, Barbara Sitek, Pumin Zhang, Fuchu He, Maria Uxue Latasa, Matías Avila, Fernando Corrales
Primary liver cancer (HCC) is recognized as the fifth most common neoplasm and the second leading cause of cancer deaths worldwide. Most risk factors are known and the molecular pathogenesis has been widely studied in the last decade; however, the underlying molecular mechanisms remain to be unveiled, as they will facilitate definition of novel biomarkers and clinical targets for more effective patient management. In this study, we utilize the B/D-HPP popular protein strategy. We report a list of popular proteins that have been highly co-cited with the expression "liver cancer"...
September 25, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28944610/last-century-forest-productivity-in-a-managed-dry-edge-scots-pine-population-the-two-sides-of-climate-warming
#9
Laura Marqués, Jaime Madrigal-González, Miguel A Zavala, J Julio Camarero, Florian Hartig
Climate change in the Mediterranean, associated with warmer temperatures and more frequent droughts, is expected to impact forest productivity and the functioning of forests ecosystems as carbon reservoirs in the region. Climate warming can positively affect forest growth by extending the growing season, whereas increasing summer drought generally reduces forest productivity and may cause growth decline, trigger dieback, hamper regeneration and increase mortality. Forest management could potentially counteract such negative effects by reducing stand density and thereby competition for water...
September 25, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28944104/the-influence-of-extracellular-rna-on-cell-behavior-in-health-disease-and-regeneration
#10
Luai Huleihel, Michelle E Scarritt, Stephen F Badylak
PURPOSE OF REVIEW: An overview of the role of extracellular RNAs (exRNA) in the regulation of homeostasis, disease progression, and regeneration is provided herein. Several exRNAs have been identified as potential biomarkers for disease and disease progression. In addition, the potential of exRNAs as a therapeutic modality is discussed. RECENT FINDINGS: Fibrotic diseases of the lung, liver, and heart, among other organs share a number of identical exRNAs which play key roles in disease pathogenesis...
March 2017: Current Pathobiology Reports
https://www.readbyqxmd.com/read/28944059/biodegradable-porous-silk-microtubes-for-tissue-vascularization
#11
V E Bosio, J Brown, M J Rodriguez, David L Kaplan
Cardiovascular diseases are the leading cause of mortality around the globe, and microvasculature replacements to help stem these diseases are not available. Additionally, some vascular surgeries needing small diameter vascular grafts present different performance requirements. In this work silk fibroin scaffolds based on silk/polyethylene oxide blends were developed as microtubes for vasculature needs and for different tissue regeneration times, mechanical properties and structural designs. Systems with 13, 14 and 15% silk alone or blended with 1 or 2% of polyethylene oxide (PEO) were used to generate porous microtubes using gel-spinning...
2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/28944026/tree-seed-traits-response-to-monsoon-climate-and-altitude-in-indian-subcontinent-with-particular-reference-to-the-himalayas
#12
Surendra P Singh, Shyam S Phartyal, Sergey Rosbakh
Seed traits are related to several ecological attributes of a plant species, including its distribution. While the storage physiology of desiccation-sensitive seeds has drawn considerable attention, their ecology has remained sidelined, particularly how the strong seasonality of precipitation in monsoonal climate affects their temporal and spatial distribution. We compiled data on seed mass, seed desiccation behavior, seed shedding, and germination periodicity in relation to monsoon and altitude for 198 native tree species of Indian Himalayas and adjoining plains to find out (1) the adaptive significance of seed mass and seed desiccation behavior in relation to monsoon and (2) the pattern of change in seed mass in relation to altitude, habitat moisture, and succession...
September 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28943462/dna-polymeric-films-as-a-support-for-cell-growth-as-a-new-material-for-regenerative-medicine-compatibility-and-applicability
#13
Cristiano Ceron Jayme, Leonardo Barcelos de Paula, Nayara Rezende, Italo Rodrigo Calori, Leonardo Pereira Franchi, Antonio Claudio Tedesco
DNA polymeric films (DNA-PFs) are a promising drug delivery system (DDS) in modern medicine. In this study, we evaluated the growth behavior of oral squamous cell carcinoma (OSCC) cells on DNA-PFs. The morphological, biochemical, and cytometric features of OSCC cell adhesion on DNA-PFs were also assessed. An initial, temporary alteration in cell morphology was observed at early time points owing to the inhibition of cell attachment to the film, which then returned to a normal morphological state at later time points...
September 21, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28943295/the-slippery-slope-of-hematopoietic-stem-cell-aging
#14
Martin Wahlestedt, David Bryder
The late stages of life are in most species, including humans, associated with a decline in overall organism maintenance/health. This applies also to the hematopoietic system, where aging associates not only to an increased predisposition for hematological malignancies, but also as a strong comorbidity factor for other diseases. Research during the last two decades have proposed that alterations at the level of hematopoietic stem cells (HSCs) might be a root cause for the hematological changes observed with age...
September 21, 2017: Experimental Hematology
https://www.readbyqxmd.com/read/28943254/sox7-is-required-for-muscle-satellite-cell-development-and-maintenance
#15
Rashida F Rajgara, Neena Lala-Tabbert, François Marchildon, Émilie Lamarche, Jennifer K MacDonald, Daryl A Scott, Alexandre Blais, Ilona S Skerjanc, Nadine Wiper-Bergeron
Satellite cells are skeletal-muscle-specific stem cells that are activated by injury to proliferate, differentiate, and fuse to enable repair. SOX7, a member of the SRY-related HMG-box family of transcription factors is expressed in quiescent satellite cells. To elucidate SOX7 function in skeletal muscle, we knocked down Sox7 expression in embryonic stem cells and primary myoblasts and generated a conditional knockout mouse in which Sox7 is excised in PAX3(+) cells. Loss of Sox7 in embryonic stem cells reduced Pax3 and Pax7 expression...
September 18, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28943242/csnk1a1-regulates-prmt1-to-maintain-the-progenitor-state-in-self-renewing-somatic-tissue
#16
Xiaomin Bao, Zurab Siprashvili, Brian J Zarnegar, Rajani M Shenoy, Eon J Rios, Natalie Nady, Kun Qu, Angela Mah, Daniel E Webster, Adam J Rubin, Glenn G Wozniak, Shiying Tao, Joanna Wysocka, Paul A Khavari
Somatic progenitors sustain tissue self-renewal while suppressing premature differentiation. Protein arginine methyltransferases (PRMTs) affect many processes; however, their role in progenitor function is incompletely understood. PRMT1 was found to be the most highly expressed PRMT in epidermal progenitors and the most downregulated PRMT during differentiation. In targeted mouse knockouts and in long-term regenerated human mosaic epidermis in vivo, epidermal PRMT1 loss abolished progenitor self-renewal and led to premature differentiation...
September 18, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28942997/facile-and-green-fabrication-of-cation-exchange-membrane-adsorber-with-unprecedented-adsorption-capacity-for-protein-purification
#17
M Kamran Khan, Jianquan Luo, Rashid Khan, Jinxin Fan, Yinhua Wan
Fabricating membrane adsorbers with high adsorption capacity and appreciable throughput for the separation and purification of protein products is challenging in biomedical and pharmaceutical industries. Herein, we report the synthesis of a novel membrane adsorber by functionalizing a nylon microfiltration membrane with alginate dialdehyde (ADA) followed by sulphonic addition, without any solvent usage, and its successful application in the purification of lysozyme. Taking advantage of abundant dual cation exchange (CEX) groups on sulphonic-ADA (S-ADA) ligands, this novel S-ADA-nylon membrane adsorber showed an unprecedented static binding capicity of 286mg/mL for lysozyme adsorption...
September 15, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28942552/soil-spore-bank-communities-of-ectomycorrhizal-fungi-in-endangered-chinese-douglas-fir-forests
#18
Zhugui Wen, Liang Shi, Yangze Tang, Lizhou Hong, Jiawang Xue, Jincheng Xing, Yahua Chen, Kazuhide Nara
Chinese Douglas-fir (Pseudotsuga sinensis) is an endangered Pinaceae species found in several isolated regions of China. Although soil spore banks of ectomycorrhizal (ECM) fungi can play an important role in seedling establishment after disturbance, such as in the well-known North American relative (Pseudotsuga menziesii), we have no information about soil spore bank communities in relict forests of Chinese Douglas-fir. We conducted bioassays of 73 soil samples collected from three Chinese Douglas-fir forests, using North American Douglas-fir as bait seedlings, and identified 19 species of ECM fungi...
September 23, 2017: Mycorrhiza
https://www.readbyqxmd.com/read/28942255/melamine-based-dendrimer-amine-modified-magnetic-nanoparticles-as-an-efficient-pb-ii-adsorbent-for-wastewater-treatment-adsorption-optimization-by-response-surface-methodology
#19
Fatemeh Jiryaei Sharahi, Afsaneh Shahbazi
Magnetic Fe3O4 nanoparticles with an average diameter of 64 nm was synthesized solvothermically and subsequently modified with melamine-based dendrimer amine (MDA-Fe3O4) via grafting method. The synthesized materials were characterized using DLS, SEM, XRD, FTIR, VSM, TGA and elemental analysis techniques. The MDA-Fe3O4 was employed for the efficient removal of Pb(II) ions from an aqueous solution. The adsorption efficiency was investigated in relation to the independent variables of Pb(II) concentration (80-250 mg L(-1)), pH of the solution (3-7), adsorbent dosage (0...
September 14, 2017: Chemosphere
https://www.readbyqxmd.com/read/28942189/anionically-reinforced-hydrogel-network-entrapped-fungal-cells-for-retention-of-cadmium-in-the-contaminated-aquatic-media
#20
Sema Çelik, Sibel Tunali Akar, Musa Şölener, Tamer Akar
A novel biomass/polymer composite was fabricated by embedding Thamnidium elegans cells in acrylic network of p(3-Methoxyprophyl)acrylamide p(MPA) enriched with 2-Akrylamido-2-methyl-1-propane sulfonic acid (AMPS). Cd(II) retention potential of hydrogel (p(MPA-co-AMPS)) increased by 20.66% times after this enrichment. The gel matrix could be effectively entrapped the biomass and resulting sorbent applied to remove Cd(II) from water in batch and continuous modes. The main physico-chemical parameters are discussed in addition to characterization, regeneration and application studies of the suggested sorbent...
September 20, 2017: Journal of Environmental Management
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