keyword
MENU ▼
Read by QxMD icon Read
search

Regeneration

keyword
https://www.readbyqxmd.com/read/28738644/biosensor-for-the-characterisation-of-hmao-b-inhibitors-and-the-quantification-of-selegiline
#1
Maximilian Aigner, Patricia Preissegger, Kurt Kalcher, Eda Mehmeti, Peter Macheroux, Dale Edmondson, Astrid Ortner
A novel human monoamine oxidase B (hMAO B) based biosensor for inhibitory measurements was developed. It allows both the characterisation of the type of enzyme inhibition and the sensitive and simple determination of inhibitors like selegiline hydrochloride. The sensor consists of a screen printed carbon working electrode modified with 20% manganese dioxide (MnO2) and the enzyme hMAO B, which was immobilised on the electrode via a dialysis membrane (regenerated cellulose, molecular weight cut-off 14000). Inhibition of hMAO B is evaluated by adding different concentrations of the inhibitor selegiline hydrochloride to the enzyme and applying a defined amount of the hMAO B substrate phenylethylamine (PEA)...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738525/mesenchymal-stem-cells-with-igf-1-and-tgf-%C3%AE-1-in-laminin-gel-for-osteochondral-defects-in-rabbits
#2
Mudasir Bashir Gugjoo, Amarpal, Ahmed Abdelbaset-Ismail, Hari Prasad Aithal, Prakash Kinjavdekar, Abhijit Motiram Pawde, Gutulla Sai Kumar, Gutulla Taru Sharma
OBJECTIVE: Healing of articular cartilage is still a challenge due to its limited potential to regenerate. In the present study, we evaluated allogenic bone marrow mesenchymal stem cells (BM-MSCs) alone or in combination with growth factors, insulin-like growth factor-1 (IGF-1) and transforming growth factor-β1 (TGF-β1) in laminin scaffolds for healing of osteochondral defects. DESIGN: Osteochondral defects of 4mm (diameter) x 5mm (depth) were induced in the rabbit knee joints and treated with phosphate-buffered saline (PBS; control), BM-MSCs, BM-MSCs in laminin, BM-MSCs in laminin with IGF-1, or BM-MSCs in laminin with IGF-1 and TGF-β1 in 10 animals each...
July 19, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28738281/edta-functionalized-fe3o4-graphene-oxide-for-efficient-removal-of-u-vi-from-aqueous-solutions
#3
Donglin Zhao, Qi Zhang, Han Xuan, Yan Chen, Kehua Zhang, Shaojie Feng, Ahmed Alsaedi, Tasawar Hayat, Changlun Chen
In this study, a regenerable magnetic ligand material (EDTA-mGO) was fabricated by binding chelating groups (EDTA) onto Fe3O4/graphene oxide and applied to remove U(VI) from aqueous solution. The sorption experiments were investigated under different experimental conditions, such as temperature, contact time and pH. EDTA-mGO showed fast removal capacity for U(VI) (<1.5h) with high sorption ability (277.43mg/g). The removal mechanisms mainly attributed to the metal-binding organic ligand (EDTA) and the electrostatic attractions between U(VI) and oxygenic functional groups...
July 17, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28737813/the-synthesis-of-cuymnzal1-zox-mixed-oxide-as-a-low-temperature-nh3-scr-catalyst-with-enhanced-catalytic-performance
#4
Qinghua Yan, Sining Chen, Lei Qiu, Yanshan Gao, Dermot O'Hare, Qiang Wang
A new type of low-temperature selective catalytic reduction (SCR) catalyst, CuyMnzAl1-zOx, derived from layered double hydroxides is presented in this contribution. By tuning the Cu/Mn/Al ratio, the optimal catalyst Cu2Mn0.5Al0.5Ox resulted in a NOx conversion of 91.2% at 150 °C, which is much higher than that of all other control catalysts, Cu2AlOx (71.1%), Cu-Mn/γ-Al2O3 (65.23%), and Mn/γ-Al2O3 (59.32%). All samples were characterized in detail using various physico-chemical techniques including XRD, BET, FTIR, TEM, H2-TPR, NH3-TPD, and XPS analyses, and the results revealed that the superior catalytic performance of the Cu2Mn0...
July 24, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28737769/local-lung-hypoxia-determines-epithelial-fate-decisions-during-alveolar-regeneration
#5
Ying Xi, Thomas Kim, Alexis N Brumwell, Ian H Driver, Ying Wei, Victor Tan, Julia R Jackson, Jianming Xu, Dong-Kee Lee, Jeffrey E Gotts, Michael A Matthay, John M Shannon, Harold A Chapman, Andrew E Vaughan
After influenza infection, lineage-negative epithelial progenitors (LNEPs) exhibit a binary response to reconstitute epithelial barriers: activating a Notch-dependent ΔNp63/cytokeratin 5 (Krt5) remodelling program or differentiating into alveolar type II cells (AEC2s). Here we show that local lung hypoxia, through hypoxia-inducible factor (HIF1α), drives Notch signalling and Krt5(pos) basal-like cell expansion. Single-cell transcriptional profiling of human AEC2s from fibrotic lungs revealed a hypoxic subpopulation with activated Notch, suppressed surfactant protein C (SPC), and transdifferentiation toward a Krt5(pos) basal-like state...
July 24, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28737694/the-role-of-p16-ink4a-pathway-in-human-epidermal-stem-cell-self-renewal-aging-and-cancer
#6
REVIEW
Daniela D'Arcangelo, Lavinia Tinaburri, Elena Dellambra
The epidermis is a self-renewing tissue. The balance between proliferation and differentiation processes is tightly regulated to ensure the maintenance of the stem cell (SC) population in the epidermis during life. Aging and cancer may be considered related endpoints of accumulating damages within epidermal self-renewing compartment. p16(INK4a) is a potent inhibitor of the G1/S-phase transition of the cell cycle. p16(INK4a) governs the processes of SC self-renewal in several tissues and its deregulation may result in aging or tumor development...
July 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28737023/monodispersed-bioactive-glass-nanoclusters-with-ultralarge-pores-and-intrinsic-exceptionally-high-mirna-loading-for-efficiently-enhancing-bone-regeneration
#7
Yumeng Xue, Yi Guo, Meng Yu, Min Wang, Peter X Ma, Bo Lei
Bioactive glass nanoparticles (BGNs) have attracted much attention in drug delivery and bone tissue regeneration, due to the advantages including biodegradation, high bone-bonding bioactivity, and facile large-scale fabrication. However, the wide biomedical applications of BGNs such as efficient gene delivery are limited due to their poor pore structure and easy aggregation. Herein, for the first time, this study reports novel monodispersed bioactive glass nanoclusters (BGNCs) with ultralarge mesopores (10-30 nm) and excellent miRNA delivery for accelerating critical-sized bone regeneration...
July 24, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28736688/the-top-50-most-cited-articles-in-cartilage-regeneration
#8
REVIEW
Ciaran K Mc Donald, Peter Moriarty, Manvydas Varzgalis, Colin Murphy
The aim of this study was to identify and analyze the top 50 most cited articles in cartilage regeneration. The impact of a scientific journal can be gauged by the total number of citations it has accrued. The top 50 most cited articles involving cartilage regeneration represent the most quoted level of evidence among this new subspecialty. This study aims to identify and analyze the 50 most cited articles in cartilage regeneration. The Web of Science™ citation indexing service was utilized to determine the most frequently cited articles published after 1956 containing "cartilage regeneration" in the "topic" or "title...
2017: BioResearch Open Access
https://www.readbyqxmd.com/read/28736687/tissue-engineered-tendon-for-enthesis-regeneration-in-a-rat-rotator-cuff-model
#9
Michael J Smietana, Pablo Moncada-Larrotiz, Ellen M Arruda, Asheesh Bedi, Lisa M Larkin
Healing of rotator cuff (RC) injuries with current suture or augmented scaffold techniques fails to regenerate the enthesis and instead forms a weaker fibrovascular scar that is prone to subsequent failure. Regeneration of the enthesis is the key to improving clinical outcomes for RC injuries. We hypothesized that the utilization of our tissue-engineered tendon to repair either an acute or a chronic full-thickness supraspinatus tear would regenerate a functional enthesis and return the biomechanics of the tendon back to that found in native tissue...
2017: BioResearch Open Access
https://www.readbyqxmd.com/read/28736606/mandibular-bone-regeneration-after-bone-slat-technique
#10
Salvatore D'Amato, Gianpaolo Tartaro, Angelo Itro, Mario Santagata
BACKGROUND: The reconstruction of alveolar ridges for implant placement is still a challenging surgical procedure, especially in the case of extensive vertical and horizontal bone atrophy. OBJECTIVE: The objective of the present study was to evaluate the quantity and quality of newly regenerated bone; clinically by means of direct clinical measuring, ridges augmented by autogenous cortical bone associated with autogenous particulate bone graft in the posterior lower jaw defect...
January 2017: Annali di Stomatologia
https://www.readbyqxmd.com/read/28736573/a-rapid-and-efficient-in-vitro-regeneration-system-for-lettuce-lactuca-sativa-l
#11
Isabel Armas, Natalia Pogrebnyak, Ilya Raskin
BACKGROUND: Successful biotechnological improvement of crop plants requires a reliable and efficient in vitro regeneration system. Lettuce (Lactuca sativa L.), one the most important vegetable crops worldwide, is strongly genotype-dependent in terms of regeneration capacity, limiting the potential for biotechnological improvement of cultivars which show recalcitrance under currently available protocols. The effect of different nutrient sources, plant hormone combinations and activated charcoal supplementation on shoot induction efficiency was evaluated on the cultivar 'RSL NFR', which had previously shown poor regeneration efficiency...
2017: Plant Methods
https://www.readbyqxmd.com/read/28736435/extracellular-vesicles-in-renal-disease
#12
REVIEW
Diana Karpman, Anne-Lie Ståhl, Ida Arvidsson
Extracellular vesicles, such as exosomes and microvesicles, are host cell-derived packages of information that allow cell-cell communication and enable cells to rid themselves of unwanted substances. The release and uptake of extracellular vesicles has important physiological functions and may also contribute to the development and propagation of inflammatory, vascular, malignant, infectious and neurodegenerative diseases. This Review describes the different types of extracellular vesicles, how they are detected and the mechanisms by which they communicate with cells and transfer information...
July 24, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28736352/the-effect-of-biocomposite-screws-on-bone-regeneration-in-a-rat-osteoporosis-model
#13
Je Hoon Jeong, Eun-Sun Jin, Ji Yeon Kim, Bora Lee, JoongKee Min, Sang Ryong Jeon, Minsu Lee, Kyoung Hyo Choi
INTRODUCTION: The aim of this study was to evaluate the efficacy of biocomposite screws used in ovariectomy (OVX) induced osteoporotic rats. METHODS: Twenty-four female Wistar rats (250-300g, 12 weeks old) were divided into 4 groups; Sham group (control), OVX-induced osteoporosis group (OVX), OVX and biodegradable (PLGA (poly-lactic-co-glycolic acid) without ß-TCP (tricalcium phosphate) screw insertion group (OVX/BSR), OVX and biocomposite (PLGA with ß-TCP) screw insertion group (OVX/CSR)...
July 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28736221/scaffold-curvature-mediated-novel-biomineralization-process-originates-a-continuous-soft-tissue-to-bone-interface
#14
Michael Paris, Andreas Götz, Inga Hettrich, Cécile M Bidan, John W C Dunlop, Hajar Razi, Ivo Zizak, Dietmar W Hutmacher, Peter Fratzl, Georg N Duda, Wolfgang Wagermaier, Amaia Cipitria
A myriad of shapes are found in biological tissues, often naturally evolved to fulfill a particular function. In the field of tissue engineering, substrate geometry influences cell behavior and tissue formation in-vitro, yet little is known how this translates to an in-vivo scenario. Here we investigate scaffold curvature-induced tissue growth, without additional growth factors or cells, in an ovine animal model. We show that soft tissue formation follows a curvature-driven tissue growth model. The highly organized endogenous soft matrix, potentially under mechanical strain, leads to a non-standard form of biomineralization, whereby the pre-existing organic matrix is mineralized without collagen remodeling and without an intermediate cartilage ossification phase...
July 20, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28736162/-skin-engineering-for-severe-burns
#15
J-J Lataillade, B Magne, E Bey, T Leclerc, M Trouillas
Severe burned patients need definitive and efficient wound coverage. Outcome of massive burns has been improved by using cultured epithelial autografts (CEA). Despite fragility, percentages of success take, cost of treatment and long-term tendency to contracture, this surgical technique has been developed in few burn centres. First improvements were to combine CEA and dermis-like substitute. Cultured skin substitutes provide earlier skin closure and satisfying functional result. These methods have been used successfully in massive burns...
July 20, 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/28735871/a-mathematical-model-for-cell-infiltration-and-proliferation-in-a-chondral-defect
#16
L S Kimpton, A Schwab, F Ehlicke, S L Waters, C P Please, J P Whiteley, H M Byrne
We develop a mathematical model to describe the regeneration of a hydrogel inserted into an ex vivo osteochondral explant. Specifically we use partial differential equations to describe the evolution of two populations of cells that migrate from the tissue surrounding the defect, proliferate, and compete for space and resources within the hydrogel. The two cell populations are chondrocytes and cells that infiltrate from the subchondral bone. Model simulations are used to investigate how different seeding strategies and growth factor placement within the hydrogel affect the spatial distribution of both cell types...
July 20, 2017: Mathematical Biosciences
https://www.readbyqxmd.com/read/28735850/enhanced-energetic-state-and-protection-from-oxidative-stress-in-human-myoblasts-overexpressing-bmi1
#17
Silvia Dibenedetto, Maria Niklison-Chirou, Claudia P Cabrera, Matthew Ellis, Lesley G Robson, Paul Knopp, Francesco Saverio Tedesco, Martina Ragazzi, Valentina Di Foggia, Michael R Barnes, Aleksandar Radunovic, Silvia Marino
The Polycomb group gene BMI1 is essential for efficient muscle regeneration in a mouse model of Duchenne muscular dystrophy, and its enhanced expression in adult skeletal muscle satellite cells ameliorates the muscle strength in this model. Here, we show that the impact of mild BMI1 overexpression observed in mouse models is translatable to human cells. In human myoblasts, BMI1 overexpression increases mitochondrial activity, leading to an enhanced energetic state with increased ATP production and concomitant protection against DNA damage both in vitro and upon xenografting in a severe dystrophic mouse model...
July 17, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28735764/bmp-2-7-heterodimer-strongly-induces-bone-regeneration-in-the-absence-of-increased-soft-tissue-inflammation
#18
Takashi Kaito, Tokimitsu Morimoto, Yuki Mori, Sadaaki Kanayama, Takahiro Makino, Shota Takenaka, Yusuke Sakai, Satoru Otsuru, Yoshichika Yoshioka, Hideki Yoshikawa
BACKGROUND CONTEXT: Bone morphogenetic protein (BMP)-2/7 heterodimer is a stronger inducer of bone regeneration than individual homodimers. However, clinical application of its potent bone induction ability may be hampered if its use is accompanied by excessive inflammatory reactions. PURPOSE: We sought to quantitatively evaluate bone induction and inflammatory reactions by BMP heterodimer and corresponding BMP homodimers using ultra-high resolution magnetic resonance imaging (MRI) and micro-computed tomography...
July 20, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28735706/amniotic-fluid-transcriptomics-reflects-novel-disease-mechanisms-in-fetuses-with-myelomeningocele
#19
Tomo Tarui, Aimee Kim, Alan Flake, Lauren Mcclain, John Stratigis, Inbar Fried, Rebecca Newman, Donna K Slonim, Diana W Bianchi
BACKGROUND: Cell-free (cf) RNA in amniotic fluid supernatant (AFS) reflects developmental changes in gene expression in the living fetus, including genes specific to the central nervous system (CNS). Although it has been previously shown that CNS-specific transcripts are present in AFS, it is not known whether changes in the AFS transcriptome reflect the specific pathophysiology of fetal CNS disorders. In myelomeningocele, there is open communication between the CNS and amniotic fluid...
July 20, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28735626/differentiation-of-hmsc-and-hpdlsc-induced-by-pge2-or-bmp-7-in-3d-models
#20
Christina Ern, Tamara Berger, Iris Frasheri, Richard Heym, Reinhard Hickel, Matthias Folwaczny
Regenerative therapies of pathogenic tissue defects are gaining increasing importance in periodontology. Among others, the osteogenic effect of BMP-7 seems to play a major role in the development of teeth and alveolar bone. Human periodontal ligament stem cells (hPDLSC), as well as human mesenchymal stem cells (hMSC), show the ability to differentiate into various types of tissues. Regarding prostaglandin E2, many studies have confirmed that it is involved in the inflammation associated to periodontitis stimulating osteoclasts, which ultimately leads to resorption of tooth supporting bone...
July 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
keyword
keyword
1220
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"