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https://www.readbyqxmd.com/read/29342064/minimally-manipulated-bone-marrow-concentrate-compared-with-microfracture-treatment-of-full-thickness-chondral-defects-a-one-year-study-in-an-equine-model
#1
Constance R Chu, Lisa A Fortier, Ashley Williams, Karin A Payne, Taralyn M McCarrel, Megan E Bowers, Diego Jaramillo
BACKGROUND: Microfracture is commonly performed for cartilage repair but usually results in fibrocartilage. Microfracture augmented by autologous bone marrow concentrate (BMC) was previously shown to yield structurally superior cartilage repairs in an equine model compared with microfracture alone. The current study was performed to test the hypothesis that autologous BMC without concomitant microfracture improves cartilage repair compared with microfracture alone. METHODS: Autologous sternal bone marrow aspirate (BMA) was concentrated using a commercial system...
January 17, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29342012/diffuse-chorioretinopathy-without-serous-detachment-associated-with-cardiac-transplantation
#2
Michael F Marmor
PURPOSE: To analyze an unusual case of widespread chorioretinopathy after cardiac transplantation for its potential etiology and clinical significance. METHODS: Clinical examinations included widefield and macular color and fundus autofluorescence photography, spectral domain optical coherence tomography, fluorescein angiography and indocyanine green angiography, full-field electroretinography, and Goldmann visual fields. PATIENT: A 44-year-old Hispanic woman was referred to rule out retinitis pigmentosa...
January 16, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29341933/the-effects-of-platelet-lysate-patches-on-the-activity-of-tendon-derived-cells
#3
Raquel Costa-Almeida, Albina R Franco, Tamagno Pesqueira, Mariana B Oliveira, Pedro S Babo, Isabel B Leonor, João F Mano, Rui L Reis, Manuela E Gomes
Platelet-derived biomaterials are widely explored as cost-effective sources of therapeutic factors, holding a strong potential for endogenous regenerative medicine. Particularly for tendon repair, treatment approaches that shift the injury environment are explored to accelerate tendon regeneration. Herein, genipin-crosslinked platelet lysate (PL) patches are proposed for the delivery of human-derived therapeutic factors in patch augmentation strategies aiming at tendon repair. Developed PL patches exhibited a controlled release profile of PL proteins, including bFGF and PDGF-BB...
January 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29341932/synthetic-extracellular-matrix-mimic-hydrogel-improves-efficacy-of-mesenchymal-stromal-cell-therapy-for-ischemic-cardiomyopathy
#4
Maria Chiara Ciuffreda, Giuseppe Malpasso, Cindy Chokoza, Deon Bezuidenhout, Kyle P Goetsch, Manuela Mura, Federica Pisano, Neil H Davies, Massimiliano Gnecchi
BACKGROUND: Mesenchymal stromal cells (MSC) repair infarcted hearts mainly through paracrine mechanisms. Low cell engraftment limits the release of soluble paracrine factors (SF) over time and, consequently, MSC efficacy. We tested whether a synthetic extracellular matrix mimic, a hydrogel containing heparin (H-HG), could ameliorate MSC engraftment and binding/release of SF, thus improving MSC therapy efficacy. METHODS AND RESULTS: In vitro, rat bone-marrow MSC (rBM-MSC) were seeded and grown into H-HG...
January 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29341383/co2-triggered-switchable-hydrophilicity-of-heterogeneous-conjugated-polymer-photocatalyst-for-enhanced-catalytic-activity-in-water
#5
Jeehye Byun, Wei Huang, Di Wang, Run Li, Kai A I Zhang
Water-compatibility of heterogeneous photocatalysts has been pursued for energy and environmental applications. However, there exists a trade-off between hydrophilicity and recyclability of the photocatalyst. Herein, we report a conjugated polymer photocatalyst with tertiary amine terminals that reversibly binds CO2 in water, generating a switchable hydrophilicity. The CO2-assisted hydrophilicity boosted up the photocatalytic efficiency in aqueous medium with minimum dosage. When CO2 was desorbed, the photocatalyst could be simply regenerated from reaction media, facilitating the repeated use of photocatalyst...
January 17, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29341335/osteogenic-efficacy-of-bmp-2-mixed-with-hydrogel-and-bone-substitute-in-peri-implant-dehiscence-defects-in-dogs-16%C3%A2-weeks-of-healing
#6
Jae-Kook Cha, Ui-Won Jung, Daniel S Thoma, Christoph H F Hämmerle, Ronald E Jung
OBJECTIVES: The objective of this study was to determine the effect of bone morphogenetic protein-2 (BMP-2) mixed with either polyethylene glycol hydrogel or synthetic bone substitute (SBS) on new bone formation in peri-implant dehiscence defects after 16 weeks of healing. MATERIALS AND METHODS: A guided bone regeneration procedure was performed in box-type peri-implant defects that were surgically prepared in six beagle dogs. The following four experimental groups were used (i) control (no graft), (ii) SBS+hydrogel, (iii) SBS+BMP-2/hydrogel and (iv) BMP-2/SBS+hydrogel...
January 17, 2018: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/29341308/stiffness-regulates-the-proliferation-and-osteogenic-odontogenic-differentiation-of-human-dental-pulp-stem-cells-via-the-wnt-signalling-pathway
#7
Nanxin Liu, Mi Zhou, Qi Zhang, Tao Zhang, Taoran Tian, Quanquan Ma, Changyue Xue, Shiyu Lin, Xiaoxiao Cai
OBJECTIVES: Researches showed that stiffness of the extracellular matrix can affect the differentiation of many stem cells. Dental pulp stem cells (DPSCs) are a promising type of adult stem cell. However, we know little about whether and how the behaviour of DPSCs is influenced by stiffness. MATERIALS AND METHODS: We carried out a study that cultured DPSCs on tunable elasticity polydimethylsiloxane substrates to investigate the influence on morphology, proliferation, osteogenic/odontogenic differentiation and its possible mechanism...
January 17, 2018: Cell Proliferation
https://www.readbyqxmd.com/read/29341108/characteristics-of-tendon-derived-stem-cells-according-to-different-factors-to-induce-the-tendinopathy
#8
Sun Jeong Kim, Da-Hyun Song, Sang Jun Kim
Tendon derived stem cells (TDSCs) have been used as a therapeutic agent and as a healing marker. However, there has been no study about the characteristics of TDSCs extracted from tendinopathic tendon tissues. The aim of this study was to find the different characteristics of TDSCs according to the factors to induce the tendinopathy. Five- and 15-week old Sprague Dawley rats were used for this study and chemically-induced and injury-induced tendinopathy models were made depending on the age of the animal for different types of tendinopathy...
January 17, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29340876/biomaterials-and-regenerative-medicine-in-urology
#9
N F Davis, E M Cunnane, M R Quinlan, J J Mulvihill, N Lawrentschuk, D M Bolton, M T Walsh
Autologous gastrointestinal tissue is the gold standard biomaterial for urinary tract reconstruction despite its long-term neuromechanical and metabolic complications. Regenerative biomaterials have been proposed as alternatives; however many are limited by a poor host derived regenerative response and deficient supportive elements for effective tissue regeneration in vivo. Urological biomaterials are sub-classified into xenogenic extracellular matrices (ECMs) or synthetic polymers. ECMs are decellularised, biocompatible, biodegradable biomaterials derived from animal organs...
January 17, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29340845/dihydrotestosterone-treatment-accelerates-autograft-reversal-sciatic-nerve-regeneration-in-rats
#10
Xiaofan Yang, Pingping Xue, Ruozheng Wei, Xin Liu, Xiang Xu, Zhenyu Liu, Yanhua Chen, Zhenbing Chen
Neuroactive steroids such as progesterone, testosterone, and their derivatives have been widely studied for their neuroprotective roles in the nervous system. Autologous nerve transplantation is considered as the gold standard repair technique when primary suture is impossible; nevertheless, this method is far from ideal. In this study, we aimed to explore the impact of dihydrotestosterone (DHT), a 5α-reduced derivative of testosterone, on the recovery of peripheral nerve injury treated with autologous nerve transplantation...
January 16, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29340649/optic-nerve-regeneration-after-crush-remodels-the-injury-site-molecular-insights-from-imaging-mass-spectrometry
#11
David T Stark, David M G Anderson, Jacky M K Kwong, Nathan Heath Patterson, Kevin L Schey, Richard M Caprioli, Joseph Caprioli
Purpose: Mammalian central nervous system axons fail to regenerate after injury. Contributing factors include limited intrinsic growth capacity and an inhibitory glial environment. Inflammation-induced optic nerve regeneration (IIR) is thought to boost retinal ganglion cell (RGC) intrinsic growth capacity through progrowth gene expression, but effects on the inhibitory glial environment of the optic nerve are unexplored. To investigate progrowth molecular changes associated with reactive gliosis during IIR, we developed an imaging mass spectrometry (IMS)-based approach that identifies discriminant molecular signals in and around optic nerve crush (ONC) sites...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29340375/enhancement-of-bmp-2-mediated-angiogenesis-and-osteogenesis-by-2-n-6-o-sulfated-chitosan-in-bone-regeneration
#12
Yuanzhong Pan, Jie Chen, Yuanman Yu, Kai Dai, Jing Wang, Changsheng Liu
Sulfated polysaccharides are attractive semi-synthesized materials that can be used as a mimic of heparan sulfate to modulate the protein activity and other physiological processes. In this study, we employed sulfated chitosan to enhance the angiogenic capacity of bone morphogenic protein-2 (BMP-2). Bone marrow stromal cells (BMSCs) cultured in a combination of BMP-2 and 2-N,6-O-sulfated chitosan (SCS) group exhibited a higher cell viability and sprouting ability. The cells also secreted more VEGF and NO. The expression patterns of angiogenic and osteogenic genes were analyzed, and VEGFR2 signaling was found to play a role in the enhancing effect of SCS...
January 17, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29340348/peri-implant-tissues-and-patient-satisfaction-after-treatment-of-vertically-augmented-atrophic-posterior-mandibles-with-intraoral-onlay-block-bone-grafts-a-retrospective-3-year-case-series-follow-up-study
#13
Amparo Aloy-Prósper, David Peñarrocha-Oltra, Maria Peñarrocha-Diago, Federico Hernández-Alfaro, Miguel Peñarrocha-Diago
PURPOSE: To evaluate the peri-implant soft and hard tissues of dental implants placed in vertically regenerated posterior mandibles with intraoral onlay block bone grafts and patient satisfaction at 3-year follow-up. MATERIALS AND METHODS: A retrospective study of patients with dental implants placed in posterior mandibular sites vertically augmented with intraoral onlay block bone grafts was carried out between 2005 and 2009 at the University of Valencia. The outcomes assessed at the 3-year follow-up visit were the peri-implant soft tissues (Plaque Index and Bleeding Index, probing depth, keratinized mucosa width, and recession), implant survival and success rates, marginal bone loss, and patient satisfaction...
January 2018: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29340346/effects-of-local-drug-and-chemical-compound-delivery-on-bone-regeneration-around-dental-implants-in-animal-models-a-systematic-review-and-meta-analysis
#14
Ali Alenezi, Bruno Chrcanovic, Ann Wennerberg
PURPOSE: One of the suggested methods for enhancing osseointegration is the local application of drug agents around implant surfaces. The aim of this review was to evaluate the methods most commonly used for local drug and chemical compound delivery to implant sites and assess their influence on osseointegration. MATERIALS AND METHODS: An electronic search was undertaken in three databases (PubMed, Scopus, Embase). The search was limited to animal experiments using endosseous implants combined with local drug delivery systems...
January 2018: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29340133/a-regional-assessment-of-white-tailed-deer-effects-on-plant-invasion
#15
Kristine M Averill, David A Mortensen, Erica A H Smithwick, Susan Kalisz, William J McShea, Norman A Bourg, John D Parker, Alejandro A Royo, Marc D Abrams, David K Apsley, Bernd Blossey, Douglas H Boucher, Kai L Caraher, Antonio DiTommaso, Sarah E Johnson, Robert Masson, Victoria A Nuzzo
Herbivores can profoundly influence plant species assembly, including plant invasion, and resulting community composition. Population increases of native herbivores, e.g. white-tailed deer (Odocoileus virginianus), combined with burgeoning plant invasions raise concerns for native plant diversity and forest regeneration. While individual researchers typically test for the impact of deer on plant invasion at a few sites, the overarching influence of deer on plant invasion across regional scales is unclear. We tested the effects of deer on the abundance and diversity of introduced and native herbaceous and woody plants across 23 white-tailed deer research sites distributed across the east-central and north-eastern USA and representing a wide range of deer densities and invasive plant abundance and identity...
February 2018: AoB Plants
https://www.readbyqxmd.com/read/29340024/chitosan-composite-scaffold-combined-with-bone-marrow-derived-mesenchymal-stem-cells-for-bone-regeneration-in-vitro-and-in-vivo-evaluation
#16
Shengqi Zang, Lei Zhu, Kefu Luo, Rui Mu, Feng Chen, Xiaocui Wei, Xiaodong Yan, Biyao Han, Xiaolei Shi, Qintao Wang, Lei Jin
The study aimed to develop a chitosan (CS)-based scaffold for repairing calvarial bone defects. We fabricated composite scaffolds made of CS and bovine-derived xenograft (BDX), characterized their physicochemical properties including pore size and porosity, absorption, degradation, and compressive strength, compared their efficacy to support in vitro proliferation and differentiation of human jaw bone marrow-derived mesenchymal stem cells (hJBMMSCs), and evaluated their bone regeneration capacity in critical-size rat calvarial defects...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29339621/highly-enhanced-adsorption-of-congo-red-by-functionalized-finger-citron-leaf-based-porous-carbon
#17
Gui-Hua Zhao, Yao-Yao Fang, Wei Dai, Na Ma
A novel high-performance porous carbon material, lanthanum(III)-doped finger-citron-leaf-based porous carbon (La/FPC), has been synthesized and used as an adsorbent for anion dye Congo red (CR). The La/FPC was characterized by nitrogen adsorption and desorption isotherms, scanning electron microscopy, transmission electron microscopy and X-ray photoelectron spectroscopy. The adsorption performance of CR by the FPC and La/FPC composites with different contents of lanthanum(III) were evaluated in fixed-bed breakthrough experiments and batch tests at room temperature (298 K)...
January 2018: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29339615/adsorption-performance-of-polydopamine-modified-attapulgite-granular-adsorbent-for-methylene-blue
#18
Weisheng Zheng, Hailing Wang, Zhaolian Zhu, Peng Wei
Polydopamine-modified granule organo-attapulgite adsorbent (PDA-GOAT) was facilely prepared via a dip-coating approach. The samples were characterized by scanning electron microscopy, X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy. Surface area and pore size were calculated from the Brunauer-Emmett-Teller method by N2 adsorption-desorption isotherm. The adsorption behaviour of methylene blue (MB) onto PDA-GOAT was systematically investigated. The experimental data revealed that the adsorption process fitted well with the pseudo-second-order kinetics equation and the adsorption isotherm fitted better with the Langmuir model...
January 2018: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29339509/biodegradable-piezoelectric-force-sensor
#19
Eli J Curry, Kai Ke, Meysam T Chorsi, Kinga S Wrobel, Albert N Miller, Avi Patel, Insoo Kim, Jianlin Feng, Lixia Yue, Qian Wu, Chia-Ling Kuo, Kevin W-H Lo, Cato T Laurencin, Horea Ilies, Prashant K Purohit, Thanh D Nguyen
Measuring vital physiological pressures is important for monitoring health status, preventing the buildup of dangerous internal forces in impaired organs, and enabling novel approaches of using mechanical stimulation for tissue regeneration. Pressure sensors are often required to be implanted and directly integrated with native soft biological systems. Therefore, the devices should be flexible and at the same time biodegradable to avoid invasive removal surgery that can damage directly interfaced tissues. Despite recent achievements in degradable electronic devices, there is still a tremendous need to develop a force sensor which only relies on safe medical materials and requires no complex fabrication process to provide accurate information on important biophysiological forces...
January 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29339492/cytocapsular-tubes-conduct-cell-translocation
#20
Tingfang Yi, Gerhard Wagner
Cell locomotion is essential for multicellular organism embryo development, organ homeostasis, tissue regeneration, immune responses, and tumor metastasis. Here we report that single mammalian cells can generate two extracellular membranous compartments: cytocapsulae and cytocapsular tubes. Cells migrate in cytocapsulae and engender cytocapsular tubes, which exhibit pleiotropic biological functions and provide tubular routes for directed cell transportation. Ultrastructural analysis by electron microscope revealed that nanoprotrusions surround and anchor cytocapsular tubes in place...
January 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
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