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https://www.readbyqxmd.com/read/29149506/integrating-soft-and-hard-tissues-via-interface-tissue-engineering
#1
REVIEW
Sahishnu Patel, Jon-Michael Caldwell, Stephen B Doty, William N Levine, Scott Rodeo, Louis J Soslowsky, Stavros Thomopoulos, Helen H Lu
The enthesis, or interface between bone and soft tissues such as ligament and tendon, is prone to injury and often does not heal post-surgical intervention. Interface tissue engineering represents an integrative strategy for regenerating the native enthesis by functionally connecting soft and hard tissues and thereby improving clinical outcome. This review focuses on integrative and cell-instructive scaffold designs that target the healing of the two most commonly injured soft tissue-bone junctions: the tendon-bone interface (e...
November 17, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29149445/the-influences-of-separators-on-capacitive-deionization-systems-in-the-cycle-of-adsorption-and-desorption
#2
Qihan Yao, Zhou Shi, Qingqing Liu, Zhengyang Gu, Ruihuan Ning
This research focused on the influence of different separator compartments on the performance of capacitive deionization (CDI) cells in terms of brackish water treatment. For comparison, different separators including filter paper(FP), carbon nanotube (CNT), and stainless steel fiber (SSF) on deionization and desorption rate of salt were examined. The best performance was obtained when the CNT separator was packed, followed by SSF and FP. Reducing the cell voltage from 1.2 to 0.4 V decreased the salt removal and electrode regeneration rate of SSF-CDI...
November 17, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29149213/optimal-design-and-control-of-an-electromechanical-transfemoral-prosthesis-with-energy-regeneration
#3
Farbod Rohani, Hanz Richter, Antonie J van den Bogert
In this paper, we present the design of an electromechanical above-knee active prosthesis with energy storage and regeneration. The system consists of geared knee and ankle motors, parallel springs for each motor, an ultracapacitor, and controllable four-quadrant power converters. The goal is to maximize the performance of the system by finding optimal controls and design parameters. A model of the system dynamics was developed, and used to solve a combined trajectory and design optimization problem. The objectives of the optimization were to minimize tracking error relative to human joint motions, as well as energy use...
2017: PloS One
https://www.readbyqxmd.com/read/29149058/neurotrophic-and-neuroregenerative-effects-of-gh-igf1
#4
Vittorio Emanuele Bianchi, Vittorio Locatelli, Laura Rizzi
INTRODUCTION: Human neurodegenerative diseases increase progressively with age and present a high social and economic burden. Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) are both growth factors exerting trophic effects on neuronal regeneration in the central nervous system (CNS) and peripheral nervous system (PNS). GH and IGF-1 stimulate protein synthesis in neurons, glia, oligodendrocytes, and Schwann cells, and favor neuronal survival, inhibiting apoptosis. This study aims to evaluate the effect of GH and IGF-1 on neurons, and their possible therapeutic clinical applications on neuron regeneration in human subjects...
November 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29148982/a-dentin-derived-hydrogel-bioink-for-3d-printing-of-cell-laden-scaffolds-for-regenerative-dentistry
#5
Avathamsa Athirasala, Anthony Tahayeri, Greeshma Thrivikraman, Cristiane Miranda Franca, Nelson Monteiro, Victor Tran, Jack Ferracane, Luiz Bertassoni
Recent studies in tissue engineering have adopted extracellular matrix (ECM) derived scaffolds as natural and cytocompatible microenvironments for tissue regeneration. The dentin matrix, specifically, has been shown to be associated with a host of soluble and insoluble signaling molecules that can promote odontogenesis. Here, we have developed a novel bioink, blending printable alginate (3% w/v) hydrogels with the soluble and insoluble fractions of the dentin matrix. We have optimized the printing parameters and the concentrations of the individual components of the bioink for print accuracy, cell viability and odontogenic potential...
November 17, 2017: Biofabrication
https://www.readbyqxmd.com/read/29148704/electrospun-poly-3-hydroxybutyrate-co-4-hydroxybutyrate-graphene-oxide-scaffold-enhanced-properties-and-promoted-in-vivo-bone-repair-in-rats
#6
Tengfei Zhou, Guo Li, Shiyu Lin, Taoran Tian, Quanquan Ma, Qi Zhang, Sirong Shi, Changyue Xue, Wenjuan Ma, Xiaoxiao Cai, Yunfeng Lin
Bone tissue engineering emerges as an advantageous technique to achieve tissue regeneration. Scaffolds for it must present excellent biomechanical properties where bare polymers poorly perform. Development for new biomaterials with high osteogenic capacity is urgently pursued. In this study, an electrospun poly(3-hydroxybutyrate-co-4-hydroxybutyrate/graphene oxide (P34HB/GO) nanofibrous scaffold is successfully fabricated and characterized. The effects of GO amount on scaffold morphology, biomechanical properties, and cellular behaviors are investigated...
November 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29148257/multiscale-memory-and-bioelectric-error-correction-in-the-cytoplasm-cytoskeleton-membrane-system
#7
REVIEW
Chris Fields, Michael Levin
A fundamental aspect of life is the modification of anatomy, physiology, and behavior in the face of changing conditions. This is especially illustrated by the adaptive regulation of growth and form that underlies the ability of most organisms-from single cells to complex large metazoa-to develop, remodel, and regenerate to specific anatomical patterns. What is the relationship of the genome and other cellular components to the robust computations that underlie this remarkable pattern homeostasis? Here we examine the role of constraints defined at the cellular level, especially endogenous bioelectricity, in generating and propagating biological information...
November 17, 2017: Wiley Interdisciplinary Reviews. Systems Biology and Medicine
https://www.readbyqxmd.com/read/29147923/anti-aminoacyl-trna-synthetase-related-myositis-and-dermatomyositis-clues-for-differential-diagnosis-on-muscle-biopsy
#8
Bruna Cerbelli, Annalinda Pisano, Serena Colafrancesco, Maria Gemma Pignataro, Marco Biffoni, Silvia Berni, Antonia De Luca, Valeria Riccieri, Roberta Priori, Guido Valesini, Giulia d'Amati, Carla Giordano
Anti-synthetase syndrome is an autoimmune disease characterized by autoantibodies toward amino acyl-tRNA synthetases (ARS), anti-Jo 1 being the most commonly detected. Muscle damage develops in up to 90% of ARS-positive patients, characterized by a necrotizing myositis restricted to the perifascicular region. This topographic distribution of muscle damage may lead to a misdiagnosis of dermatomyositis (DM) at muscle biopsy. We compared morphological, immunohistochemical, and histoenzymatic features of muscle from ARS-positive patients (n = 11) with those of DM (n = 7) providing clues for their differential diagnosis...
November 16, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29147820/cue-signal-response-analysis-in-3d-chondrocyte-scaffolds-with-anabolic-stimuli
#9
Michael Neidlin, Antonion Korcari, Giorgos Macheras, Leonidas G Alexopoulos
Articular cartilage is an avascular connective tissue responsible for bearing loads. Cell signaling plays a central role in cartilage homeostasis and tissue engineering by directing chondrocytes to synthesize/degrade the extracellular matrix or promote inflammatory responses. The aim of this paper was to investigate anabolic, catabolic and inflammatory pathways of well-known and underreported anabolic stimuli in 3D chondrocyte cultures and connect them to diverse cartilage responses including matrix regeneration and cell communication...
November 16, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29147713/variation-of-the-bone-forming-ability-with-the-physicochemical-properties-of-calcium-phosphate-bone-substitutes
#10
Rongquan Duan, Davide Barbieri, Xiaoman Luo, Jie Weng, Chongyun Bao, Joost D de Bruijn, Huipin Yuan
Because of their bioactive properties and chemical similarity to the inorganic component of bone, calcium phosphate (CaP) materials are widely used for bone regeneration. Six commercially available CaP bone substitutes (Bio-Oss, Actifuse, Bi-Ostetic, MBCP, Vitoss and chronOs) as well as two tricalcium phosphate (TCP) ceramics with either a micron-scale (TCP-B) or submicron-scale (TCP-S) surface structure are characterized and their bone forming potential is evaluated in a canine ectopic implantation model. After 12 weeks of implantation in the paraspinal muscle of four beagles, sporadic bone (0...
November 17, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29147666/sympathetic-denervation-accelerates-wound-contraction-but-inhibits-reepithelialization-and-pericyte-proliferation-in-diabetic-mice
#11
Zhifang Zheng, Yu Wan, Yishu Liu, Yu Yang, Jianbing Tang, Wenhua Huang, Biao Cheng
Previous studies focused on the effects of sympathetic denervation with 6-hydroxydopamine (6-OHDA) on nondiabetic wounds, but the effects of 6-OHDA on diabetic wounds have not been previously reported. In this study, treated mice received intraperitoneal 6-OHDA, and control mice received intraperitoneal injections of normal saline. Full-thickness wounds were established on the backs of mice. The wounds were sectioned (four mice per group) for analysis at 2, 5, 7, 10, 14, 17, and 21 days after injury. The wound areas in the control group were larger than those in the treatment group...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29147489/the-effect-of-platelet-rich-plasma-on-human-mesenchymal-stem-cell-induced-bone-regeneration-of-canine-alveolar-defects-with-calcium-phosphate-based-scaffolds
#12
Reihaneh Shafieian, Maryam Moghaddam Matin, Amin Rahpeyma, Alireza Fazel, Hamideh Salari Sedigh, Ariane Sadr-Nabavi, Halimeh Hassanzadeh, Alireza Ebrahimzadeh-Bideskan
Objectives: Autologous bone transplantation known as the "gold standard" to reconstruction of osseous defects has known disadvantages. This study was designed to explore the effects of hydroxy-apatite/tricalcium-phosphate (HA/TCP) and platelet-rich plasma (PRP) on the osteogenesis ability of human adipose-derived mesenchymal stem cells (hAdMSCs) in vitro and in vivo. Materials and Methods: hAdMSCs were incubated with HA/TCP granules and/or PRP in vitro and then, cell proliferation and differentiation was assessed by MTT assay, AZR S staining and SEM examination...
October 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29147434/acute-radiation-induced-changes-in-sprague-dawley-rat-submandibular-glands-a-histomorphometric-analysis
#13
Manu Krishnan, Aatish Tennavan, Seema Saraswathy, Tarun Sekhri, Ajay Kumar Singh, Velu Nair
Background: Radiation-induced xerostomia is a distressing clinical condition that starts appearing from the initial stages of radiotherapy in head and neck cancer patients. Though submandibular glands contribute to maximum of the "resting salivary" secretions, most of the acute xerostomia experiments so far reported have been on animal parotid glands. Therefore, we assessed and quantified the histologic changes in submandibular glands of Sprague-Dawley (SD) rats using histomorphometry, 24 hours after radiation...
April 2017: World Journal of Oncology
https://www.readbyqxmd.com/read/29146943/cryopreservation-of-human-mesenchymal-stem-cells-in-an-allogeneic-bioscaffold-based-on-platelet-rich-plasma-and-synovial-fluid
#14
Haritz Gurruchaga, Laura Saenz Del Burgo, Ane Garate, Diego Delgado, Pello Sanchez, Gorka Orive, Jesús Ciriza, Mikel Sanchez, Jose Luis Pedraz
Transplantation of mesenchymal stem cells (MSCs) has emerged as an alternative strategy to treat knee osteoarthritis. In this context, MSCs derived from synovial fluid could provide higher chondrogenic and cartilage regeneration, presenting synovial fluid as an appropriate MSCs source. An allogeneic and biomimetic bioscaffold composed of Platelet Rich Plasma and synovial fluid that preserve and mimics the natural environment of MSCs isolated from knee has also been developed. We have optimized the cryopreservation of knee-isolated MSCs embedded within the aforementioned biomimetic scaffold, in order to create a reserve of young autologous embedded knee MSCs for future clinical applications...
November 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29146735/reduced-dnmt3a-increases-gdf5-expression-with-suppressed-satellite-cell-differentiation-and-impaired-skeletal-muscle-regeneration
#15
Yukino Hatazawa, Yusuke Ono, Yuma Hirose, Sayaka Kanai, Nobuharu L Fujii, Shuichi Machida, Ichizo Nishino, Takahiko Shimizu, Masaki Okano, Yasutomi Kamei, Yoshihiro Ogawa
DNA methylation is an epigenetic mechanism regulating gene expression. In this study, we observed that DNA methyltransferase 3a (Dnmt3a) expression is decreased after muscle atrophy. We made skeletal muscle-specific Dnmt3a knockout mice (Dnmt3a-KO mice). The regeneration capacity after muscle injury was markedly decreased in Dnmt3a-KO mice. Diminished mRNA and protein expression of Dnmt3a were observed in skeletal muscles as well as in satellite cells, which are important for muscle regeneration, in Dnmt3a-KO mice...
November 16, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29146360/behaviour-of-trolox-with-macromolecule-bound-antioxidants-in-aqueous-medium-inhibition-of-auto-regeneration-mechanism
#16
Ecem Evrim Çelik, Jose Manuel Amigo Rubio, Vural Gökmen
This work aimed at investigating the behaviour of Trolox, vitamin E analogue, in presence of macromolecule-bound antioxidants in aqueous radical medium. Three main groups of macromolecule-bound antioxidants were assayed: dietary fiber (DF), protein and lipid-bound antioxidants, represented by whole wheat, soybean and olive oil products, respectively. Experimental studies were carried out in aqueous ABTS (2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid)) radical medium. Trolox and macromolecule-bound antioxidants were added to radical separately and together in different concentrations...
March 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29146294/distinct-effects-of-interleukin-6-classic-and-trans-signaling-in-bone-fracture-healing
#17
Katja Prystaz, Kathrin Kaiser, Anna Kovtun, Melanie Haffner-Luntzer, Verena Fischer, Anna E Rapp, Astrid Liedert, Gudrun Strauss, Georg H Waetzig, Stefan Rose-John, Anita Ignatius
Bone healing is a complex process with closely linked phases of inflammation, regeneration, and remodeling. Interleukin-6 (IL-6) may crucially regulate this process; however, the underlying mechanisms are presently unclear. IL-6 signals are transmitted via the transmembrane glycoprotein 130 by two distinct mechanisms: classic signaling employing the membrane-anchored IL-6 receptor, and trans-signaling using its soluble form. Here, we investigated the hypothesis that IL-6 classic and trans-signaling have different functions during bone healing...
November 13, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29146220/autologous-chondrocyte-implantation-for-talar-osteochondral-lesions-comparison-between-5-year-follow-up-magnetic-resonance-imaging-findings-and-7-year-follow-up-clinical-results
#18
Gherardo Pagliazzi, Francesca Vannini, Milva Battaglia, Laura Ramponi, Roberto Buda
Autologous chondrocyte implantation (ACI) is an established surgical procedure that has provided satisfactory results. The aim of the present study was to correlate the clinical outcomes of a series of 20 patients treated by ACI at a 7-year follow-up examination with the magnetic resonance imaging (MRI) T2-mapping 5-year follow-up findings. We evaluated 20 patients using the American Orthopaedic Foot and Ankle Society (AOFAS) score preoperatively and the established follow-up protocol until 87.2 ± 14.5 months...
November 14, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29146144/drosophila-adult-muscle-development-and-regeneration
#19
REVIEW
Rajesh D Gunage, Nagaraju Dhanyasi, Heinrich Reichert, K VijayRaghavan
Myogenesis is a highly orchestrated, complex developmental process by which cell lineages that are mesodermal in origin generate differentiated multinucleate muscle cells as a final product. Considerable insight into the process of myogenesis has been obtained for the embryonic development of the larval muscles of Drosophila. More recently, the postembryonic development of the muscles of the adult fly has become a focus of experimental investigation of myogenesis since specific flight muscles of the fly manifest remarkable similarities to vertebrate muscles in their development and organization...
November 13, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29146058/methylation-associated-silencing-of-sfrp1-gene-in-high-grade-serous-ovarian-carcinomas
#20
Vedran Kardum, Valentina Karin, Mislav Glibo, Anita Skrtic, Tamara Nikuseva Martic, Nermina Ibisevic, Faruk Skenderi, Semir Vranic, Ljiljana Serman
Wnt is a highly conserved signaling pathway responsible for tissue regeneration, maintenance and differentiation of stem cells in adults. Its aberrant activation through reduced expression of Wnt signaling pathway inhibitors, such as proteins from the SFRP family, is commonly seen in many tumors. In the present study we explored SFRP1 protein expression using immunohistochemistry in 11 low-grade serous ovarian carcinomas (LGSC), 42 high-grade serous ovarian carcinomas (HGSC), and 5 normal ovarian tissues (controls)...
December 2017: Annals of Diagnostic Pathology
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