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https://www.readbyqxmd.com/read/27933435/ranolazine-promotes-muscle-differentiation-and-reduces-oxidative-stress-in-c2c12-skeletal-muscle-cells
#1
Terruzzi Ileana, Montesano Anna, Senesi Pamela, Vacante Fernanda, Benedini Stefano, Luzi Livio
PURPOSE: The purpose of this study is to investigate Ranolazine action on skeletal muscle differentiation and mitochondrial oxidative phenomena. Ranolazine, an antianginal drug, which acts blocking the late INaL current, was shown to lower hemoglobin A1c in patients with diabetes. In the present study, we hypothesized an action of Ranolazine on skeletal muscle cells regeneration and oxidative process, leading to a reduction of insulin resistance. METHODS: 10 μM Ranolazine was added to C2C12 murine myoblastic cells during proliferation, differentiation and newly formed myotubes...
December 8, 2016: Endocrine
https://www.readbyqxmd.com/read/27933339/efficacy-and-safety-of-osteoporosis-medications-in-a-rat-model-of-late-stage-chronic-kidney-disease-accompanied-by-secondary-hyperparathyroidism-and-hyperphosphatemia
#2
M Ota, M Takahata, T Shimizu, Y Kanehira, H Kimura-Suda, Y Kameda, H Hamano, S Hiratsuka, D Sato, N Iwasaki
: This study showed that bisphosphonate was safe and effective for the treatment of bone disorders in stage 4 chronic kidney disease (CKD) rats. Intermittent teriparatide therapy showed an anabolic action on bone even under secondary hyperparathyroidism conditions without having an adverse effect on mineral metabolism in late-stage CKD. INTRODUCTION: Patients with late-stage CKD are at high risk for fragility fractures. However, there are no consensus on the efficacy and safety of osteoporosis medications for patients with late-stage CKD...
December 8, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27933298/non-targeted-plasma-metabolome-of-early-and-late-lactation-gilts
#3
Lea A Rempel, Jeremy R Miles, William T Oliver, Corey D Broeckling
Female pigs nursing their first litter (first-parity gilts) have increased energy requirements not only to support their piglets, but they themselves are still maturing. Non-targeted plasma metabolomics were used to investigate the differences between (1) post-farrowing and weaning (early or late lactation), (2) degree of body condition loss after lactation (extreme or minimal), and (3) interactions; to potentially identify compounds or pathways that could aide in alleviating energetic demands of lactation in gilts...
2016: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/27933157/absconding-reducing-failure-to-return-in-adult-mental-health-wards
#4
Jill Bailey, Bethan Page, Nokuthula Ndimande, Julie Connell, Charles Vincent
Failing to return from leave from acute psychiatric wards can have a range of negative consequences for patients, relatives and staff. This study used quality improvement methodology to improve the processes around patient leave and time away from the ward. The aim of this study was to improve rates of on-time return from leave by detained and informal patients by 50%. Following a baseline period, four interventions were implemented and refined using PDSA cycles. The main outcome measure was the proportion of periods of leave where the patient returned on time...
2016: BMJ Quality Improvement Reports
https://www.readbyqxmd.com/read/27932967/better-not-to-know-emotion-regulation-fails-to-benefit-from-affective-cueing
#5
Siwei Liu, Marie-Anne Vanderhasselt, Juan Zhou, Annett Schirmer
Often we know whether an upcoming event is going to be good or bad. But does that knowledge help us regulate ensuing emotions? To address this question, we exposed participants to alleged social feedback that was either positive or negative. On half the trials, a preceding cue indicated the feedback's affective quality. On the remaining trials, the cue was uninformative. In two different blocks, participants either appraised feedback spontaneously or down-regulated ensuing emotions using a controlled appraisal strategy...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27931772/the-impact-of-depressive-symptoms-on-healthcare-costs-in-late-life-longitudinal-findings-from-the-agemoode-study
#6
Jens-Oliver Bock, André Hajek, Siegfried Weyerer, Jochen Werle, Michael Wagner, Wolfgang Maier, Anne Stark, Hanna Kaduszkiewicz, Birgitt Wiese, Lilia Moor, Janine Stein, Steffi G Riedel-Heller, Hans-Helmut König
OBJECTIVE: To examine whether depressive symptoms affect healthcare costs in old age longitudinally. DESIGN: Multicenter prospective observational cohort study (two waves with nt1 = 1,195 and nt2 = 951) in Germany. SETTING: Community. PARTICIPANTS: Participants aged 75 years and older recruited via general practitioners. MEASUREMENTS: Depressive symptoms were assessed by the Geriatric Depression Scale (GDS)...
November 2, 2016: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27930688/a-time-to-wean-impact-of-weaning-age-on-anxiety-like-behaviour-and-stability-of-behavioural-traits-in-full-adulthood
#7
S Helene Richter, Niklas Kästner, Dirk-Heinz Loddenkemper, Sylvia Kaiser, Norbert Sachser
In mammals, weaning constitutes an important phase in the progression to adulthood. It comprises the termination of suckling and is characterized by several changes in the behaviour of both mother and offspring. Furthermore, numerous studies in rodents have shown that the time point of weaning shapes the behavioural profile of the young. Most of these studies, however, have focused on 'early weaning', while relatively little work has been done to study 'late weaning' effects. The aim of the present study was therefore to explore behavioural effects of 'late weaning', and furthermore to gain insights into modulating effects of weaning age on the consistency of behavioural expressions over time...
2016: PloS One
https://www.readbyqxmd.com/read/27930581/associations-between-interventions-for-urolithiasis-and-urinary-tract-cancer-among-patients-in-taiwan-the-effect-of-early-intervention
#8
Chien-Liang Lin, Wen-Tsung Huang, Wen-Chou Fan, Yin-Hsun Feng, Chia-Ho Lin, Chian-Shiung Lin, Chih-Cheng Lu, Tse-Chou Cheng, Chao-Jung Tsao, Sheng-Hsiang Lin
The aim of this study was to investigate cancer risk in patients with a history of urolithiasis and to determine whether intervention for calculi attenuated the risk of subsequent urinary tract cancer (UTC).Using data from the National Health Insurance Research Database in Taiwan, we performed a nationwide cohort study enrolling participants (n = 42,732) aged > 30 years who were diagnosed with urinary tract calculi between 2000 and 2009. Age- and gender-matched insured individuals (n = 213,660) found in the health service records over the same period were recruited as the control group...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27930453/whole-body-vibration-improves-early-rate-of-torque-development-in-individuals-with-acl-reconstruction
#9
Derek N Pamukoff, Brian Pietrosimone, Eric D Ryan, Dustin R Lee, Lee E Brown, J Troy Blackburn
The purpose of this study was to compare the effect of whole body vibration (WBV) and local muscle vibration (LMV) on early and late quadriceps rate of torque development (RTD), and electromechanical delay (EMD) in individuals with anterior cruciate ligament reconstruction (ACLR). 20 individuals with ACLR were recruited for this study. Participants performed isometric squats while being exposed to WBV, LMV, or no vibration (control) in a randomized order during separate visits. Quadriceps early and late quadriceps RTD, and EMD were assessed during a maximal voluntary isometric knee extension prior to and immediately following WBV, LMV, or control...
November 19, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27929673/effect-of-gadoxetate-disodium-on-arterial-phase-respiratory-waveforms-using-a-quantitative-fast-fourier-transformation-based-analysis
#10
Matthew S Davenport, Dariya I Malyarenko, Yuxi Pang, Hero K Hussain, Thomas L Chenevert
OBJECTIVE: The purpose of this study is to investigate the effect of gadoxetate disodium administration on arterial phase respiratory waveforms. SUBJECTS AND METHODS: From 2013 to 2015, 107 subjects undergoing liver MRI with either gadoxetate disodium (10 mL diluted 1:1 with saline; injection rate, 2 mL/s; n = 40) or gadobenate dimeglumine (0.2 mL/kg; maximum, 20 mL; injection rate, 2 mL/s; n = 67) were enrolled. Respiratory waveforms obtained during unenhanced and dynamic contrast-enhanced phases were filtered by a physicist, who was blinded to contrast agent and imaging phase, to eliminate electronic and cardiac noise using fast Fourier transformation...
December 8, 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27928888/self-care-tools-to-treat-depressive-symptoms-in-patients-with-age-related-eye-disease-a-randomized-controlled-clinical-trial
#11
Hortence Kamga, Jane McCusker, Mark Yaffe, Maida Sewitch, Tamara Sussman, Erin Strumpf, Sébastien Olivier, Walter Wittich, Solmaz Moghadaszadeh, Ellen E Freeman
BACKGROUND: Depression is very common in people with age-related eye disease. Our goal was to determine if self-care tools plus limited telephone support could reduce depressive symptoms in patients with age-related macular degeneration (AMD) or diabetic retinopathy (DR). DESIGN: A single-blind randomized controlled clinical trial was conducted at Maisonneuve-Rosemont Hospital in Montreal, Canada. PARTICIPANTS: Eighty participants were recruited METHODS: To be eligible, participants must have had either late stage AMD or DR, at least mild depressive symptoms, and visual acuity better than 20/200...
December 7, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/27928720/cardioprotection-of-exercise-preconditioning-involving-heat-shock-protein-70-and-concurrent-autophagy-a-potential-chaperone-assisted-selective-macroautophagy-effect
#12
Yang Yuan, Shan-Shan Pan, Yu-Jun Shen
It has been confirmed that exercise preconditioning (EP) has a protective effect on acute cardiovascular stress. However, how Hsp70 participates in EP-induced cardioprotection is unknown. EP may involve Hsp70 to repair unfolded proteins or may also stabilize the function of the endoplasmic reticulum via Hsp70-related autophagy to work on a protective formation. Our EP protocol involves four periods of 10 min running with 10 min recovery intervals. We added a period of exhaustive running to test this protective effect, using histology and molecular biotechnology methods to detect related markers...
December 7, 2016: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/27928603/-laparoscopic-heller-myotomy-after-failed-poem-and-multiple-balloon-dilatations-better-late-than-never
#13
L Giulini, A Dubecz, H J Stein
BACKGROUND: Despite the lack of long-term results, peroral endoscopic myotomy (POEM) has been increasingly propagated as a feasible alternative to pneumatic balloon dilatation (BD) and laparoscopic Heller myotomy (LHM) in patients with achalasia. After a long-term follow-up, a large percentage of patients reported recurrence of dysphagia. It is unclear which kind of procedure (redo POEM or LHM) should be utilized in these patients with failed POEM. CASE REPORT AND RESULTS: We report the case of a 37-year-old female patient with type I achalasia who was successfully treated with LHM after a failed POEM procedure...
December 7, 2016: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/27928500/recent-advances-in-understanding-and-managing-psoriatic-arthritis
#14
REVIEW
Dafna D Gladman
This article reviews recent advances in psoriatic arthritis (PsA) over the past several years with emphasis on early diagnosis, better understanding of pathogenesis, and new therapeutic approaches. Early diagnosis is important, since people who present late do not fare as well. There are a number of clinical, laboratory, and ultrasound features that can help identify patients destined to develop PsA, and several screening tools have been developed. It is recognized that genetic and epigenetic factors, as well as T cells and cytokines, play a role in the pathogenesis of PsA, and several targets have been identified for therapeutic interventions...
2016: F1000Research
https://www.readbyqxmd.com/read/27928425/synthesis-of-acyl-oleanolic-acid-uracil-conjugates-and-their-anti-tumor-activity
#15
Wei-Bin Mo, Chun-Hua Su, Jia-Yan Huang, Jun Liu, Zhen-Feng Chen, Ke-Guang Cheng
BACKGROUND: Oleanolic acid, which can be isolated from many foods and medicinal plants, has been reported to possess diverse biological activities. It has been found that the acylation of the hydroxyl groups of the A-ring in the triterpene skeleton of oleanolic acid could be favorable for biological activities. The pyrimidinyl group has been constructed in many new compounds in various anti-tumor studies. RESULTS: Five acyl oleanolic acid-uracil conjugates were synthesized...
2016: Chemistry Central Journal
https://www.readbyqxmd.com/read/27928106/cell-death-affected-by-dental-alloys-modes-and-mechanisms
#16
Yu Pan, Lei Jiang, Honglei Lin, Hui Cheng
Previous reports have demonstrated that ions released from dental alloys might cause cytotoxicity. However, how dental alloys influence the organism has not been extensively studied. In order to make it clear, the cytotoxic effect of four dental alloys on L929 cells was evaluated by flow cytometry (FCM) and Real-time quantitative PCR assay (Real-time qPCR) to identify the cell death mode and its biological mechanism. The cells were treated with the leach liquors of cobalt-chromium (Co-Cr), commercially pure titanium (CP-Ti), palladium-based (Pd-based) and gold-platinum (Au-Pt) alloys for 48 and 72 h...
December 6, 2016: Dental Materials Journal
https://www.readbyqxmd.com/read/27927608/pretravel-health-advice-among-australians-returning-from-bali-indonesia-a-randomized-controlled-trial-protocol
#17
Chloe A Thomson, Robyn A Gibbs, Jane S Heyworth, Carolien Giele, Martin J Firth, Paul V Effler
BACKGROUND: The effect of pretravel health advice (PTHA) on travel-related illness rates is poorly understood, and to date there are no published randomized controlled trials evaluating the impact of PTHA outcomes. OBJECTIVE: This study aims to determine the effect of an online PTHA intervention on travel-related illness rates in Western Australians visiting Bali, Indonesia. METHODS: Western Australian travelers to Bali will be recruited online before departure and will be randomly allocated to an intervention or control group by computer algorithm...
December 7, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27927046/advances-in-chemical-pharmacotherapy-to-manage-advanced-breast-cancer
#18
Andrea Gombos, Ahmad Awada
Advanced breast cancer is still incurable. However, patients diagnosed with this fatal disease live longer. The selection of systemic therapy is mainly based on molecular subtype. The aim of management in these patients is to not only improve outcome, but also to maintain quality of life. Areas covered: In this paper we focus on available treatments and drugs under late development in the three main subtypes of breast cancer: luminal (hormone receptor positive), HER2 positive and triple negative disease. Main advances during the last years have been made in the treatment of HER2 positive breast cancer with the approval of several new targeted agents...
December 7, 2016: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/27926854/structural-characterization-and-statistical-mechanical-model-of-epidermal-patterns
#19
Duyu Chen, Wen Yih Aw, Danelle Devenport, Salvatore Torquato
In proliferating epithelia of mammalian skin, cells of irregular polygon-like shapes pack into complex, nearly flat two-dimensional structures that are pliable to deformations. In this work, we employ various sensitive correlation functions to quantitatively characterize structural features of evolving packings of epithelial cells across length scales in mouse skin. We find that the pair statistics in direct space (correlation function) and Fourier space (structure factor) of the cell centroids in the early stages of embryonic development show structural directional dependence (statistical anisotropy), which is a reflection of the fact that cells are stretched, which promotes uniaxial growth along the epithelial plane...
December 6, 2016: Biophysical Journal
https://www.readbyqxmd.com/read/27926676/long-term-restoration-of-anterior-shoulder-stability-a-retrospective-analysis-of-arthroscopic-bankart-repair-versus-open-latarjet-procedure
#20
Stefan M Zimmermann, Max J Scheyerer, Mazda Farshad, Sabrina Catanzaro, Stefan Rahm, Christian Gerber
BACKGROUND: Various operative techniques are used for treating recurrent anterior shoulder instability, and good mid-term results have been reported. The purpose of this study was to compare shoulder stability after treatment with the 2 commonly performed procedures, the arthroscopic Bankart soft-tissue repair and the open coracoid transfer according to Latarjet. METHODS: A comparative, retrospective case-cohort analysis of 360 patients (364 shoulders) who had primary repair for recurrent anterior shoulder instability between 1998 and 2007 was performed...
December 7, 2016: Journal of Bone and Joint Surgery. American Volume
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