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https://www.readbyqxmd.com/read/28806488/serotonergic-5-ht2b-receptors-in-mitral-valvulopathy-bone-marrow-mobilization-of-endothelial-progenitors
#1
Estelle Ayme-Dietrich, Roland Lawson, Francine Côté, Claudia de Tapia, Sylvia Da Silva, Claudine Ebel, Béatrice Hechler, Christian Gachet, Jérome Guyonnet, Hélène Rouillard, Jordane Stoltz, Emily Quentin, Sophie Banas, François Daubeuf, Nelly Frossard, Bernard Gasser, Jean-Philippe Mazzucotelli, Olivier Hermine, Luc Maroteaux, Laurent Monassier
BACKGROUND: Valvular heart disease is highly prevalent in industrialized countries. Chronic use of anorexigens, amphetamine or ergot derivatives targeting the serotonin system has been associated with valvular heart disease. PURPOSE AND EXPERIMENTAL APPROACH: Here, we investigated the contribution of serotonin receptors in a mouse model of valve degeneration induced by nordexfenfluramine, the main metabolite of the anorexigens dexfenfluramine and benfluorex. KEY RESULTS: Chronically activated 5-HT2B receptors by nordexfenfluramine in mice mimicked early steps of mitral valve remodelling attested by increased valve thickness, and cell density in a thick extracellular matrix...
August 14, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28806175/point-of-care-ultrasound-facilitated-detection-of-femoral-occlusive-septic-emboli-during-mitral-valve-surgery-a-case-report
#2
Melissa L Bellomy, Susan Eagle, Mias Pretorius, Ben R Barton, Yafen Liang
Acute lower extremity ischemia from septic emboli is a surgical emergency. Timely diagnosis and management are critical to improve patient outcome. However, traditional diagnostic modalities such as intraoperative angiogram are time-consuming, require special equipment and personnel, and introduce contrast exposure for critically ill patients. There are limited reports of utilization of point-of-care ultrasound to detect peripheral septic emboli. We present a case where femoral occlusive septic emboli were identified by point-of-care ultrasound after mitral valve replacement...
August 10, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28805039/unnatural-milieu-thrombus-after-transcatheter-mitral-valve-replacement
#3
EDITORIAL
Jaffar M Khan, Robert J Lederman
What the article teaches Transcatheter heart valve thrombosis in the mitral position causes increased valve gradients, valve dysfunction, and symptoms, and may be associated with lack of therapeutic anticoagulation. How it will impact practice Anticoagulation with a vitamin K antagonist should be considered in all patients undergoing transcatheter mitral valve replacement. What new research/study would help answer the question posed Efficacy, optimal duration, and safety of anticoagulation therapy, balancing reduced thrombosis against increased bleeding risk, needs to be assessed in larger cohort studies and prospective trials...
August 1, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28804599/circulating-exosome-microrna-associated-with-heart-failure-secondary-to-myxomatous-mitral-valve-disease-in-a-naturally-occurring-canine-model
#4
Vicky K Yang, Kerry A Loughran, Dawn M Meola, Christine M Juhr, Kristen E Thane, Airiel M Davis, Andrew M Hoffman
Myxomatous mitral valve disease (MMVD) is functionally and histologically identical to mitral valve prolapse (MVP) in humans. Currently, there are no medical treatments that can delay the progression of this valvular disease or associated cardiac remodelling. Therefore, there is a need to understand the molecular pathology associated with MMVD and MVP better, and thus identify potential therapeutic targets. Circulating exosomes contain small RNA, including miRNA, which reflect cell physiology and pathology...
2017: Journal of Extracellular Vesicles
https://www.readbyqxmd.com/read/28803841/coronary-artery-embolism-from-a-blood-cyst-of-the-mitral-valve
#5
Nejc Pavsic, Zvezdana Dolenc-Strazar, Andreja Cerne Cercek, Tomislav Klokocovnik, Katja Prokselj
Blood cysts are benign, congenital tumours of the heart endothelium, found most commonly on heart valves. Adult cases are rare, since most spontaneously regress with age. However, reports of symptomatic cases with embolic phenomena and valve dysfunction have been described. We present a case of a previously healthy 44-year-old woman with no cardiovascular risk factors who developed acute myocardial infarction caused by coronary artery embolism from a blood cyst of the anterior mitral valve leaflet.
July 19, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28803350/comparison-of-mitral-competence-after-mitral-repair-with-papillary-muscle-approximation-versus-papillary-muscle-relocation-for-functional-mitral-regurgitation
#6
Koji Furukawa, Mitsuhiro Yano, Eisaku Nakamura, Masakazu Matsuyama, Masanori Nishimura, Katsuya Kawagoe, Kunihide Nakamura
The purpose of this study was to evaluate the surgical results of papillary muscle approximation (PMA) and papillary muscle relocation (PMR) for functional mitral regurgitation (FMR) and to compare the effects of both procedures on the change in mitral regurgitation (MR) and echocardiogram parameters associated with tethering. Eighteen patients with moderate-to-severe FMR (MR grade ≥2) who underwent PMA or PMR were retrospectively analyzed. Underlying diseases were ischemic cardiomyopathy, idiopathic dilated cardiomyopathy, and aortic valve disease for seven, six, and five patients, respectively...
August 12, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28803216/3d-2d-registration-with-superabundant-vessel-reconstruction-for-cardiac-resynchronization-therapy
#7
Daniel Toth, Maria Panayiotou, Alexander Brost, Jonathan M Behar, Christopher A Rinaldi, Kawal S Rhode, Peter Mountney
A key component of image guided interventions is the registration of preoperative and intraoperative images. Classical registration approaches rely on cross-modality information; however, in modalities such as MRI and X-ray there may not be sufficient cross-modality information. This paper proposes a fundamentally different registration approach which uses adjacent anatomical structures with superabundant vessel reconstruction and dynamic outlier rejection. In the targeted clinical scenario of cardiac resynchronization therapy (CRT) delivery, preoperative, non contrast-enhanced, MRI is registered to intraoperative, contrasted X-ray fluoroscopy...
August 5, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28801688/-tricuspid-valve-regurgitation-indications-and-operative-techniques
#8
R Lange, N Piazza, T Günther
Functional tricuspid valve (TV) regurgitation secondary to left heart disease (e.g. mitral insufficiency and stenosis) is observed in 75% of the patients with TV regurgitation and is thus the most common etiology; therefore, the majority of patients who require TV surgery, undergo concomitant mitral and/or aortic valve surgery. Uncorrected moderate and severe TV regurgitation may persist or even worsen after mitral valve surgery, leading to progressive heart failure and death. Patients with moderate to severe TV regurgitation show a 3-year survival rate of 40%...
August 11, 2017: Herz
https://www.readbyqxmd.com/read/28801075/doppler-assessment-of-diastolic-function-reflect-the-severity-of-injury-in-rats-with-chronic-heart-failure
#9
Pablo Sanchez, Jordan J Lancaster, Kyle Weigand, Saffie-Alrahman Ezz-Eldin Mohran, Steven Goldman, Elizabeth Juneman
OBJECTIVE: For chronic heart failure (CHF), more emphasis has been placed on evaluation of systolic as opposed to diastolic function. Within the study of diastology, measurements of left ventricular (LV) longitudinal myocardial relaxation have the most validation. Anterior wall radial myocardial tissue relaxation velocities along with mitral valve inflow (MVI) patterns are applicable diastolic parameters in the differentiation between moderate and severe disease in the ischemic rat model of CHF...
August 8, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28800987/dynamic-three-dimensional-geometry-of-the-aortic-valve-apparatus-a-feasibility-study
#10
Arash Khamooshian, Yannis Amador, Ting Hai, Jelliffe Jeganathan, Maria Saraf, Eitezaz Mahmood, Robina Matyal, Kamal R Khabbaz, Massimo Mariani, Feroze Mahmood
OBJECTIVE: To provide (1) an overview of the aortic valve (AV) apparatus anatomy and nomenclature, and (2) data regarding the normal AV apparatus geometry and dynamism during the cardiac cycle obtained from three-dimensional transesophageal echocardiography (3D TEE). DESIGN: Retrospective feasibility study. SETTING: A single-center university teaching hospital. PARTICIPANTS: The study was performed on data of 10 patients with a nonregurgitant, nonstenotic aortic valve undergoing cardiac surgery...
August 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28800856/-impact-of-mitral-annuloplasty-combined-with-surgical-revascularization-in-ischemic-mitral-regurgitation
#11
M Tribak, M Konaté, B Ould Hbib, P Konan, L Mahfoudi, A El Hassani, A Daouda, F Lachhab, N Bendagha, A Soufiani, J Fila, S Maghraoui, A Bensouda, L Marmade, S Moughil
INTRODUCTION: Ischemic Mitral Regurgitation (IMR) is a serious complication of coronary artery disease and is associated with a poor prognosis. The optimal surgical treatment of IMR involves controversies in its indications and modalities. OBJECTIVES: To determine whether mitral annuloplasty associated with surgical revascularization improved short and mid terms outcomes compared with revascularization alone in patients with IMR. METHODS: Between January 2007 and January 2011, 81 patients operated on Department of Cardiovascular Surgery "B" were included in this study divided into 3 groups...
August 8, 2017: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/28799521/transcatheter-mitral-valve-replacement-long-term-outcomes-of-first-in-man-experience-with-an-apically-tethered-device-a-case-series-from-a-single-centre
#12
Alison Duncan, Anan Daqa, James Yeh, Simon Davies, Anselm Uebing, Cesare Quarto, Neil Moat
AIMS: Transcatheter mitral valve replacement (TMVR) is a novel technique for treating mitral regurgitation. We report 18-month/2-year outcomes of the 5 first-in-man patients undergoing chronic TMVR with the Tendyne device. METHODS AND RESULTS: Five patients (STS score 14%-23%) underwent TMVR using a Tendyne system under compassionate use at a single centre. 1 patient (who was noncompliant with anti-coagulation) died 9 months after TMVR following a cerebrovascular accident...
August 13, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28799132/the-analysis-of-mitral-annular-disjunction-detected-by-echocardiography-and-comparison-with-previously-reported-pathological-data
#13
Toshiko Konda, Tomoko Tani, Naoko Suganuma, Hitomi Nakamura, Toshiaki Sumida, Yoko Fujii, Junichi Kawai, Takeshi Kitai, Kitae Kim, Shuichiro Kaji, Yutaka Furukawa
BACKGROUND: Mitral annular disjunction is a structural abnormality of the mitral annulus fibrosus and is pathologically defined by a separation between the atrial wall-mitral valve junction and the left ventricular attachment. Mitral annular disjunction can cause hypermobility of the mitral valve apparatus and is often associated with mitral valve prolapse (MVP). The aim of this study was to investigate the frequency and characteristics of mitral annular disjunction in the patients referred to an echocardiography laboratory and to compare these with previously reported pathological data...
August 10, 2017: Journal of Echocardiography
https://www.readbyqxmd.com/read/28799109/difficult-diagnosis-of-ruptured-mitral-valve-aneurysm-because-of-severe-mitral-annular-calcification
#14
Takahiro Sakamoto, Hiroyuki Yoshitomi, Akihiro Endo, Kazuaki Tanabe
No abstract text is available yet for this article.
August 10, 2017: Journal of Echocardiography
https://www.readbyqxmd.com/read/28797681/extranodal-rosai-dorfman-disease-arising-in-the-heart-clinical-course-and-review-of-literature
#15
Amin Heidarian, Ayesha Anwar, M A Haseeb, Raavi Gupta
Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is a nonmalignant disease of unknown etiology. It may present as bilateral, massive, painless cervical lymphadenopathy; however, one third of the cases have extranodal involvement. Extranodal sites include soft tissue, skin, upper respiratory and gastrointestinal tracts, and central nervous system, with head and neck being the most common. Here we report a rare case of intracardiac RDD in a 46-year-old, African-American female who presented with worsening shortness of breath and fatigue for 7 weeks...
July 4, 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/28797677/emergence-of-atrioventricular-nodal-reentry-tachycardia-after-surgical-or-catheter-ablation-for-atrial-fibrillation-are-we-creating-the-arrhythmia-substrate
#16
Jorge Romero, Saurabh Kumar, Fujii Akira, David F Briceño, Usha B Tedrow, Laurence Epstein, Roy John, William G Stevenson, Gregory F Michaud
BACKGROUND: Atrioventricular nodal reentry tachycardia (AVNRT) is common in adults and often involves reentry through two or more AV nodal-atrial connections. Although AVNRT can be a trigger for atrial fibrillation (AF), we have observed new onset AVNRT after AF ablation procedures. OBJECTIVE: To determine whether ablation involving the septum or proximal coronary sinus during AF ablation may create a substrate favorable for AVNRT METHODS: Cases of ablation for persistent AF who required a repeat ablation procedure between 2009 to 2016 were reviewed for diagnosis of AVNRT...
August 7, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28797608/repair-strategies-based-on-pathological-characteristics-of-the-rheumatic-mitral-valve-in-chinese-patients
#17
Luo Tiange, Meng Xu
BACKGROUND: We aimed to clarify the pathological characteristics of rheumatic mitral valve disease in Chinese individuals, as well as to determine the appropriate rheumatic mitral valve repair strategy according to such characteristics. METHODS: We obtained detailed statistics regarding the pathological characteristics of patients who underwent mitral valve repair or replacement for rheumatic disease during the past year at our centre. The outcomes of different repair techniques were compared...
June 28, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28793912/re-evaluation-of-hypoplastic-left-heart-syndrome-from-a-developmental-and-morphological-perspective
#18
A Crucean, A Alqahtani, D J Barron, W J Brawn, R V Richardson, J O'Sullivan, R H Anderson, D J Henderson, B Chaudhry
BACKGROUND: Hypoplastic left heart syndrome (HLHS) covers a spectrum of rare congenital anomalies characterised by a non-apex forming left ventricle and stenosis/atresia of the mitral and aortic valves. Despite many studies, the causes of HLHS remain unclear and there are conflicting views regarding the role of flow, valvar or myocardial abnormalities in its pathogenesis, all of which were proposed prior to the description of the second heart field. Our aim was to re-evaluate the patterns of malformation in HLHS in relation to recognised cardiac progenitor populations, with a view to providing aetiologically useful sub-groupings for genomic studies...
August 10, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28792140/effect-of-patient-prosthesis-mismatch-in-aortic-position-on-late-onset-tricuspid-regurgitation-and-clinical-outcomes-after-double-valve-replacement
#19
Seung Hyun Lee, Young Nam Youn, Byung Chul Chang, Hyun Chel Joo, Sak Lee, Kyung Jong Yoo
PURPOSE: Significant late-onset tricuspid regurgitation (TR) is unfortunately common after double valve replacement (DVR); however, its underlying factors remain undefined. We evaluated the effect of aortic patient-prosthesis mismatch (PPM) on late-onset TR and clinical outcomes after DVR. MATERIALS AND METHODS: Of the 2392 consecutive patients who underwent aortic valve replacement between January 1990 and May 2014 at our institution, we retrospectively studied 462 patients who underwent DVR (excluding concomitant tricuspid valvular annuloplasty or replacement)...
September 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28791992/-morphological-features-of-the-myocardium-of-the-atrial-appendages-in-patients-with-different-forms-of-atrial-fibrillation
#20
T V Sukhacheva, V A Vaskovsky, A Sh Revishvili, R A Serov
AIM: to analyze the morphological features of the myocardium of the atrial appendages in patients with different forms of atrial fibrillation (AF) and to compare the findings with the clinical parameters of patients. MATERIAL AND METHODS: Light and electron microscopies were used to examine the myocardium of the atrial appendages in adult patients with paroxysmal (PAF), persistent (PrAF), or long-standing persistent atrial fibrillation (LPAF) and in comparison group patients with sinus rhythm without history of AF...
2017: Arkhiv Patologii
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