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https://www.readbyqxmd.com/read/29244962/expression-of-the-frizzled-receptors-and-their-co-receptors-in-calcified-human-aortic-valves
#1
Ateeque Siddique, Bin Yu, Kashif Khan, Ryan Buyting, Hamood Al-Kindi, Hossny Alaws, Eric Rhéaume, Jean-Claude Tardif, Renzo Cecere, Adel Schwertani
The cellular mechanisms that induce calcific aortic stenosis are yet to be unravelled. Wnt signaling is increasingly being considered as a major player in the disease process. However, the presence of Wnt Frizzled receptors (Fzd) and co-receptors LRP5 and 6 in normal and diseased human aortic valves remains to be elucidated. Immunohistochemistry and qPCR were used to determine Fzd receptor expression in normal and calcified human aortic valve tissue, as well as human aortic valve interstitial cells (HAVICs) isolated from calcified and normal human aortic valves...
December 15, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29244161/the-impact-of-coronary-anomalies-on-the-outcome-in-aortic-valve-surgery-comparison-of-bicuspid-aortic-valve-versus-tricuspid-aortic-valve-morphotype
#2
Shiho Naito, Johannes Petersen, Hermann Reichenspurner, Evaldas Girdauskas
OBJECTIVES: The association of anomalous anatomy of coronary arteries and bicuspid aortic valve (BAV) has been sporadically reported. Our aim was to evaluate the prevalence of coronary anomalies between BAV and tricuspid aortic valve (TAV) and to analyse their impact on major adverse cardiac events during and after aortic valve surgery. METHODS: A total of 1099 consecutive patients who received preoperative coronary evaluation and elective aortic valve replacement/repair between January 2013 and July 2016 at our institution were involved...
December 12, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29244124/a-challenging-case-of-aortic-valve-commissure-detachment-with-fibrous-strand-ruptures-mimicking-infective-endocarditis
#3
Shun Nishino, Nozomi Watanabe, Koji Furukawa, Yoshisato Shibata
No abstract text is available yet for this article.
December 12, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29243687/sutureless-valves-and-the-quality-of-perfusion-towards-a-goal-directed-aortic-valve-replacement
#4
Antonino S Rubino, Carmelo Mignosa
BACKGROUND: Aim of this study was to assess the potential differences in respecting the principles of goal-directed perfusion between aortic valve replacement with sutureless vs conventional stented bioprostheses. METHODS: Data from 94 consecutive patients undergoing aortic valve replacement with Perceval sutureless valve, with or without concomitant CABG, were compared to a contemporary cohort of 116 patients receiving conventional stented bioprostheses. Propensity score matching was used to reduce selection bias...
December 14, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29242202/calcific-aortic-valve-disease-insights-into-the-genetics-of-vascular-ageing
#5
EDITORIAL
Richmond W Jeremy
No abstract text is available yet for this article.
December 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/29242201/familial-aggregation-of-aortic-valvular-stenosis-a-nationwide-study-of-sibling-risk
#6
Andreas Martinsson, Xinjun Li, Bengt Zöller, Pontus Andell, Charlotte Andersson, Kristina Sundquist, J Gustav Smith
BACKGROUND: Aortic valvular stenosis (AS) is the most common cause of cardiac valvular replacement surgery. During the last century, the pathogenesis of AS has undergone transitions in developed countries, from rheumatic heart disease to a degenerative calcific pathogenesis. Although a familial component has been described for a subset of cases with a bicuspid valve, data are limited on the overall familial aggregation of this disease. METHODS AND RESULTS: Contemporary information on 6 117 263 Swedish siblings, of which 13 442 had a clinical diagnosis of AS, was collected from the nationwide Swedish Multi-Generation Register and the National Patient Register...
December 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/29242098/complex-aortic-coarctation-and-a-bicuspid-aortic-valve-with-severe-stenosis-in-a-68-year-old-woman
#7
Arnulfo Cuitláhuac Arroyo-Rodríguez, David-Leonel Molina-Cancino, Eduardo Arias-Navarro, Aurora Del Carmen Ojeda-Peña, Santiago Sandoval-Navarrete
No abstract text is available yet for this article.
December 11, 2017: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/29242071/impact-of-acute-postoperative-limb-ischemia-after-cardiac-and-thoracic-aortic-surgery
#8
Ian W Folkert, Paul J Foley, Grace J Wang, Benjamin M Jackson, Joseph E Bavaria, Nimesh D Desai, Ronald M Fairman, Scott M Damrauer
OBJECTIVE: Acute limb ischemia (ALI) is the cause of significant morbidity and mortality. Although ALI after cardiac surgery is associated with high rates of morbidity and mortality, there are no robust, controlled analyses of the risk factors and outcomes of ALI in this setting. We aimed to identify risk factors for and to delineate outcomes after ALI in patients undergoing cardiac surgery. METHODS: We performed a retrospective review of prospectively collected data on patients undergoing cardiac surgery at our institution between 2002 and 2012...
December 11, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29241492/mechanical-intervention-for-aortic-valve-stenosis%C3%A2-in-patients-with-heart-failure-and%C3%A2-reduced%C3%A2-ejection-fraction
#9
REVIEW
Johannes Steiner, Josep Rodés-Cabau, David R Holmes, Martin M LeWinter, Harold L Dauerman
The risk and benefit of mechanical interventions in valvular heart disease have been primarily described among patients with normal ejection fraction. The advent of nonsurgical mechanical interventions for aortic stenosis (transcatheter aortic valve replacement) may alter the risk-benefit ratio for patients who would otherwise be at increased risk for valve surgery. This review describes the epidemiology and pathophysiology of aortic stenosis with heart failure and reduced ejection fraction and summarizes the current registry and clinical trial data applicable to this frequently encountered high-risk group...
December 19, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29239149/agreement-between-ccnexfin-co-trek-cardiac-output-and-intermittent-cold-bolus-pulmonary-thermodilution-in-a-prospective-multi-centre-study
#10
Nicolaas H Sperna Weiland, Jim W de Wever, Yoni van Duivenvoorde, Christa Boer, Ludmil Mitrev, Muhammad Muntazar, Kinjal Patel, Markus W Hollmann, Benedikt Preckel
BACKGROUND: The ccNexfin system uses the CO-trek algorithm to analyse a non-invasively obtained arterial pressure waveform and calculate cardiac output (NEXCO). It remains matter of debate whether NEXCO can replace invasive, pulmonary artery catheter derived, cold-bolus pulmonary thermodilution cardiac output measurement (PACCO). This study aimed at testing NEXCO-PACCO agreement in a large sample size, multi-centre study. We hypothesized that agreement between NEXCO and PACCO would be demonstrated by a mean accuracy (bias) < 0...
December 13, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29238100/clinical-outcomes-and-quality-of-life-after-surgery-for-dilated-ascending-aorta-at-the-time-of-aortic-valve-replacement-wrapping-versus-graft-replacement
#11
Tomonobu Abe, Sachie Terazawa, Hideki Ito, Yoshiyuki Tokuda, Kazuro Fujimoto, Masato Mutsuga, Yuji Narita, Hideki Oshima, Akihiko Usui
Wrapping and graft replacement are two optional procedures for the treatment of dilated ascending aorta at the time of aortic valve replacement (AVR). Wrapping is considered less invasive. The aim of this study was to compare the short- and long-term clinical outcomes as well as the long-term quality of life in patients undergoing these two procedures.This study enrolled 40 consecutive patients with dilated ascending aorta who had undergone either wrapping (WAA group, n=20) or replacement (RAA group, n=20) of the ascending aorta at the time of AVR...
November 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29238013/definitive-determinant-of-late-significant-tricuspid-regurgitation-after-aortic-valve-replacement
#12
Shin Yajima, Daisuke Yoshioka, Koichi Toda, Satsuki Fukushima, Shigeru Miyagawa, Yasushi Yoshikawa, Shunsuke Saito, Keitaro Domae, Takayoshi Ueno, Toru Kuratani, Yoshiki Sawa
BACKGROUND: Uncertainties remain regarding the course of existing tricuspid regurgitation (TR) after aortic valve replacement (AVR), and its long-term impact on outcome. We investigated changes in existing TR after isolated AVR for severe aortic stenosis (AS), the impact of preoperative TR on long-term outcome, and predictors of late significant TR.Methods and Results:After excluding mild mitral regurgitation and severe TR, 226 consecutive patients undergoing isolated AVR for severe AS between 2002 and 2015 were reviewed...
December 14, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29237015/perceval-less-invasive-aortic-replacement-register-multicentric-spanish-experience-with-the-perceval-s-bioprosthesis-in-moderate-high-risk-aortic-surgery
#13
Elisabet Berastegui García, Maria Luisa Camara Rosell, Francisco Estevez Cid, Eladio Sanchez Dominguez, Remedios Rios Barrera, Fabrizio Sbraga, Julio Garcia Puente, Elena Rosello Diez, Gregorio Pablo Cuerpo Caballero, Juan Bustamante Munguira, Guillermo Reyes Copa, Marian Tena Pajuelo, Santiago Serrano Fiz, Jose Alfonso Buendía Miñano, Ivan García Martin, Jose Cuenca Castillo, Sergio Cánovas Lopez, Angel Gonzalez Pinto, Xavier Ruyra Baliarda
OBJECTIVES: The development of new percutaneous and surgical techniques has reduced the risk associated with aortic valve replacement procedures. We present the results of a Spanish register after initiating a programme for sutureless prostheses in moderate-high-risk patients. METHODS: This prospective multicentre study was carried out from November 2013 to November 2016. Data were obtained from 448 patients in whom a Perceval S prosthesis was implanted. RESULTS: The mean age was 79...
December 8, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29236195/measures-of-subclinical-cardiac-dysfunction-and-increased-filling-pressures-associate-with-pulmonary-arterial-pressure-in-the-general-population-results-from-the-population-based-rotterdam-study
#14
Ryan J Billar, Maarten J G Leening, Daphne Merkus, Guy G O Brusselle, Albert Hofman, Bruno H Ch Stricker, H Ardeschir Ghofrani, Oscar H Franco, Henning Gall, Janine F Felix
Pulmonary hypertension is associated with increased mortality and morbidity in the elderly population. Heart failure is a common cause of pulmonary hypertension. Yet, the relation between left heart parameters reflective of subclinical cardiac dysfunction and increased filling pressures, and pulmonary arterial pressures in the elderly population remains elusive. Within the population-based Rotterdam Study, 2592 unselected participants with a mean age of 72.6 years (61.4% women) had complete echocardiography data available...
December 13, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29236149/transcatheter-aortic-valve-replacement-with-balloon-expandable-valve-analysis-of-initial-experience-in-china
#15
Y Shen, H Zhang, L Zhang, H Li, H Mao, Y Pei, Z Jing, Q Lu
BACKGROUND: Transcatheter aortic valve replacement (TAVR) is widely applied for the treatment of severe aortic stenosis (AS) in developed countries; however, in China, it is still in the early stage of utilization. On the basis of previous studies, this work explored the feasibility of TAVR in patients with severe AS in China and analyzed the cause of death in four cases. METHODS: This retrospective study included 20 patients who had severe AS and underwent TAVR with a balloon-expandable system (Edwards SAPIEN XT) in our hospital from January 2011 to June 2016...
December 13, 2017: Herz
https://www.readbyqxmd.com/read/29235436/bioprosthetic-aortic-valve-leaflet-thrombosis-detected-by-multidetector-computed-tomography-is-associated-with-adverse-cerebrovascular-events-a-meta-analysis-of-observational-studies
#16
Hashrul N Rashid, Robert P Gooley, Nitesh Nerlekar, Abdul R Ihdayhid, Liam M McCormick, Arthur Nasis, James D Cameron, Adam J Brown
AIMS: Leaflet thrombosis (LT) has become increasingly recognised following transcatheter and surgical aortic ABV replacement and can be reliably identified by MDCT. However, it is ongoing debate whether MDCT-defined LT is associated with adverse cerebrovascular outcomes. We performed a systematic review and meta-analysis to assess the incidence and clinical outcomes associated with multidetector computed tomography (MDCT)-defined leaflet thrombosis following aortic bioprosthetic valve (ABV) replacement...
December 12, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29235435/transcatheter-aortic-valve-in-valve-treatment-in-prior-sorin-freedom-solo-valve
#17
Mohammed Shamim Rahman, James Cockburn, Uday Trivedi, David Hildick-Smith
No abstract text is available yet for this article.
December 12, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29235151/one-stage-ascending-to-abdominal-aortic-bypass-with-concomitant-aortic-valve-procedures-for-aortic-coarctation-combined-with-aortic-valve-pathology-in-adult-patients
#18
Ren Changwei, Lizhong Sun, Shangdong Xu, Yongqiang Lai
OBJECTIVE: This study aims to evaluate the results of one-stage ascending-to-abdominal aortic bypass and aortic valve replacement for concomitant aortic coarctation combined with aortic valve pathology. METHODS: From June 2009 to March 2017, 28 consecutive adult patients (23 males and five females) with aortic coarctation combined with aortic valve pathology underwent one-stage ascending-to-abdominal aorta bypass and aortic valve replacement or a Bentall procedure...
December 12, 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/29235147/transapical-mitral-valve-in-valve-ring-implantation-with-the-edwards-sapien-3-prosthesis
#19
Javier Gualis, Rodrigo Estevez-Loureiro, David Alonso, Mario Castaño
We present the case of a high-risk patient with symptomatic severe mitral regurgitation following a surgical annuloplasty ring. An inverted aortic Edwards Sapien 3 bioprosthesis (Edwards Lifesciences, Irvine, CA) was successfully implanted through a transapical approach inside the previously implanted annuloplasty ring.
December 12, 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/29234970/aortic-valve-reconstruction-using-autologous-pericardium-ozaki-procedure-for-active-infective-endocarditis-a-case-report
#20
Kimiaki Okada, Yoshito Inoue, Hirofumi Haida, Satoru Suzuki
Approximately one-third of patients with infective endocarditis require surgical treatment, but the ideal procedure that prevents infection ensures long durability and maintains quality of life remains unclear. A 21-year-old man who was diagnosed with aortic active infective endocarditis was referred to our hospital for surgical treatment. Echocardiography showed bicuspid aortic valve, severe aortic regurgitation, a large vegetation, and a paravalvular abscess. We planned to perform elective surgical treatment after antibiotic therapy; however, progression to heart failure required urgent operation...
December 12, 2017: General Thoracic and Cardiovascular Surgery
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