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KLF15

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https://www.readbyqxmd.com/read/28978511/chronic-stress-inhibits-growth-and-induces-proteolytic-mechanisms-through-two-different-non-overlapping-pathways-in-the-skeletal-muscle-of-a-teleost-fish
#1
Cristián Andrés Valenzuela, Rodrigo Zuloaga, Luis Mercado, Ingibjörg Eir Einarsdottir, Bjorn Thrandur Bjornsson, Juan Antonio Valdes, Alfredo Molina
Chronic stress detrimentally affects animal health and homeostasis, with somatic growth, and thus skeletal muscle, being particularly affected. A detailed understanding of the underlying endocrine and molecular mechanisms of how chronic stress affects skeletal muscle growth remains lacking. To address this issue, the present study assessed primary (plasma cortisol), secondary (key components of the GH/IGF system, muscular proteolytic pathways and apoptosis), and tertiary (growth performance) stress responses in fine flounder (Paralichthys adspersus) exposed to crowding chronic stress...
October 4, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28938412/renal-metabolic-programming-is-linked-to-the-dynamic-regulation-of-a-leptin-klf15-axis-and-akt-ampk%C3%AE-signaling-in-male-offspring-of-obese-dams
#2
Philipp Kasper, Christina Vohlen, Katharina Dinger, Jasmine Mohr, Eva Hucklenbruch-Rother, Ruth Janoschek, Jessica Köth, Jan Matthes, Sarah Appel, Jörg Dötsch, Miguel A Alejandre Alcazar
Childhood obesity is associated with renal diseases. Maternal obesity is a risk factor linked to increased adipocytokines and metabolic disorders in the offspring. Therefore, we studied the impact of maternal obesity on renal-intrinsic insulin and adipocytokine signaling and on renal function and structure. To induce maternal obesity, female mice were fed a high-fat diet (HFD) or a standard diet (SD; control group) prior to mating, during gestation, and throughout lactation. A third group of dams was fed HFD only during lactation (HFD-Lac)...
October 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28925362/generation-of-a-klf15-homozygous-knockout-human-embryonic-stem-cell-line-using-paired-crispr-cas9n-and-human-cardiomyocytes-derivation
#3
Claudia Noack, Luis Peter Haupt, Wolfram-Hubertus Zimmermann, Katrin Streckfuss-Bömeke, Laura Cecilia Zelarayán
Krueppel-like factor 15 (KLF15) is abundantly expressed in liver, kidney, and muscle, including myocardium. In the adult heart KLF15 is important to maintain homeostasis and to repress hypertrophic remodeling. We generated a homozygous hESC KLF15 knockout (KO) line using paired CRISPR/Cas9n. KLF15-KO cells maintained full pluripotency and differentiation potential as well as genomic integrity. We demonstrated that KLF15-KO cells can be differentiated into morphologically normal cardiomyocytes turning them into a valuable tool for studying human KLF15-mediated mechanisms resulting in human cardiac dysfunction...
August 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28923246/klf15-regulates-in%C3%A2-vitro-chondrogenic-differentiation-of-human-mesenchymal-stem-cells-by-targeting-sox9
#4
Zhuoyue Song, Xiaolei Lian, Yang Wang, Yong Xiang, Guangheng Li
Mesenchymal stem cells (MSCs) are multipotent stromal cells residing in the bone marrow. MSCs have the potential to differentiate into adipocytes, chondrocytes, and other types of cells. However, the mechanism underlying MSC differentiation is still not fully understood. Here we aimed to investigate the function of the Kruppel-like factor (KLF) transcriptional factor family in regulating chondrogenic differentiation from human MSCs. Among the KLF family members, KLF15 was activated during different models of chondrogenic differentiation in a time-dependent manner...
November 18, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28830816/klf15-regulates-dopamine-d2-receptor-and-participates-in-mouse-models-of-neuropathic-pain
#5
Junfei Zhou, Fang Wang, Chang Xu, Zipeng Zhou, Wei Zhang
Neuropathic pain is caused by damage to the nervous system, resulting in aberrant pain. The mechanism underlying neuropathic pain remains largely unknown. Krüppel-like factor 15 (KLF15) is a member of the Krüppel-like factor family of transcriptional factors. Here in this study, we aimed to investigate the potential role of the transcriptional factor KLF15 in neuropathic pain. The mRNA and protein levels of Klf15 were significantly increased in the neurons of mouse undergoing neuropathic pain induced by sciatic nerve chronic constrictive injury (CCI) or unilateral spared nerve injury (SNI)...
October 14, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28814144/-express-intrathecal-administration-of-ayx2-dna-decoy-produces-a-long-term-pain-treatment-in-rat-models-of-chronic-pain-by-inhibiting-the-klf6-klf9-and-klf15-transcription-factors
#6
Julien Mamet, Michael Klukinov, Scott Harris, Donald C Manning, Simon Xie, Conrado Pascual, Bradley K Taylor, Renee R Donahue, David C Yeomans
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28794031/combinatorial-effects-of-the-glucocorticoid-receptor-and-kr%C3%A3-ppel-like-transcription-factor-15-on-bovine-herpesvirus-1-transcription-and-productive-infection
#7
Fouad S El-Mayet, Laximan Sawant, Prasanth Thunuguntla, Clinton Jones
Bovine herpesvirus 1 (BoHV-1), an important bovine pathogen, establishes lifelong latency in sensory neurons. Latently infected calves consistently reactivate from latency following a single intravenous injection of the synthetic corticosteroid dexamethasone. The immediate early transcription unit 1 (IEtu1) promoter, which drives bovine ICP0 (bICP0) and bICP4 expression, is stimulated by dexamethasone because it contains two glucocorticoid receptor (GR) response elements (GREs). Several Krüppel-like transcription factors (KLF), including KLF15, are induced during reactivation from latency, and they stimulate certain viral promoters and productive infection...
November 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28670390/klf16-promotes-proliferation-in-gastric-cancer-cells-via-regulating-p21-and-cdk4
#8
Pei Ma, Chong-Qi Sun, Yan-Fen Wang, Yu-Tian Pan, Qin-Nan Chen, Wei-Tao Liu, Jie Liu, Chen-Hui Zhao, Yong-Qian Shu, Wei Li
Krüppel-like factors (KLFs), such as KLF4, KLF2, KLF5 and KLF15, have been extensively investigated in multi-cancers. However, KLF16, a member of KLFs, hasn't been well identified in cancer, especially in gastric cancer (GC). Here, we investigated the roles of KLF16 in GC. In present study, we found that KLF16 expression levels were significantly up-regulated in GC tissues compared to adjacent normal tissues both in protein and mRNA levels by using immunohistochemistry assays (IHC) and real-time quantitative PCR (qPCR)...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28651950/the-loss-of-kr%C3%A3-ppel-like-factor-15-in-foxd1-stromal-cells-exacerbates-kidney-fibrosis
#9
Xiangchen Gu, Sandeep K Mallipattu, Yiqing Guo, Monica P Revelo, Jesse Pace, Timothy Miller, Xiang Gao, Mukesh K Jain, Agnieszka B Bialkowska, Vincent W Yang, John C He, Changlin Mei
Large epidemiological studies clearly demonstrate that multiple episodes of acute kidney injury contribute to the development and progression of kidney fibrosis. Although our understanding of kidney fibrosis has improved in the past two decades, we have limited therapeutic strategies to halt its progression. Myofibroblast differentiation and proliferation remain critical to the progression of kidney fibrosis. Although canonical Wnt signaling can trigger the activation of myofibroblasts in the kidney, mediators of Wnt inhibition in the resident progenitor cells are unclear...
June 24, 2017: Kidney International
https://www.readbyqxmd.com/read/28605459/copy-number-variants-are-enriched-in-individuals-with-early-onset-obesity-and-highlight-novel-pathogenic-pathways
#10
Maria Pettersson, Heli Viljakainen, Petra Loid, Taina Mustila, Minna Pekkinen, Miriam Armenio, Johanna C Andersson-Assarsson, Outi Mäkitie, Anna Lindstrand
Context: Only a few genetic causes for childhood obesity have been identified to date. Copy number variants (CNVs) are known to contribute to obesity, both syndromic (15q11.2 deletions, Prader-Willi syndrome) and nonsyndromic (16p11.2 deletions) obesity. Objective: To study the contribution of CNVs to early-onset obesity and evaluate the expression of candidate genes in subcutaneous adipose tissue. Design and Setting: A case-control study in a tertiary academic center...
August 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28570579/global-transcriptome-profiling-identifies-klf15-and-slc25a10-as-modifiers-of-adipocytes-insulin-sensitivity-in-obese-women
#11
Agné Kulyté, Anna Ehrlund, Peter Arner, Ingrid Dahlman
Although the mechanisms linking obesity to insulin resistance (IR) and type 2 diabetes (T2D) are not entirely understood, it is likely that alterations of adipose tissue function are involved. The aim of this study was to identify new genes controlling insulin sensitivity in adipocytes from obese women with either insulin resistant (OIR) or sensitive (OIS) adipocytes. Insulin sensitivity was first determined by measuring lipogenesis in isolated adipocytes from abdominal subcutaneous white adipose tissue (WAT) in a large observational study...
2017: PloS One
https://www.readbyqxmd.com/read/28481224/intermittent-glucocorticoid-steroid-dosing-enhances-muscle-repair-without-eliciting-muscle-atrophy
#12
Mattia Quattrocelli, David Y Barefield, James L Warner, Andy H Vo, Michele Hadhazy, Judy U Earley, Alexis R Demonbreun, Elizabeth M McNally
Glucocorticoid steroids such as prednisone are prescribed for chronic muscle conditions such as Duchenne muscular dystrophy, where their use is associated with prolonged ambulation. The positive effects of chronic steroid treatment in muscular dystrophy are paradoxical because these steroids are also known to trigger muscle atrophy. Chronic steroid use usually involves once-daily dosing, although weekly dosing in children has been suggested for its reduced side effects on behavior. In this work, we tested steroid dosing in mice and found that a single pulse of glucocorticoid steroids improved sarcolemmal repair through increased expression of annexins A1 and A6, which mediate myofiber repair...
June 1, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28465484/sirt3-klf15-signaling-ameliorates-kidney-injury-induced-by-hypertension
#13
Na Li, Jie Zhang, Xuefang Yan, Chen Zhang, Hui Liu, Xiaolan Shan, Jingyuan Li, Yi Yang, Chengmin Huang, Peng Zhang, Yun Zhang, Peili Bu
Renal fibrosis participates in the progression of hypertension-induced kidney injury. The effect of SIRT3, a member of the NAD+-dependent deacetylase family, in hypertensive nephropathy remains unclear. In this study, we found that SIRT3 was reduced after angiotensin II (AngII) treatment both in vivo and in vitro. Furthermore, SIRT3-knockout mice aggravated hypertension-induced renal dysfunction and renal fibrosis via chronic AngII infusion (2000 ng/kg per minute for 42 days). On the contrary, SIRT3-overexpression mice attenuated AngII-induced kidney injury compared with wild-type mice...
June 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28421457/klf15-inhibits-cell-proliferation-in-gastric-cancer-cells-via-up-regulating-cdkn1a-p21-and-cdkn1c-p57-expression
#14
Chongqi Sun, Pei Ma, Yanfen Wang, Weitao Liu, Qinnan Chen, Yutian Pan, Chenhui Zhao, Yingchen Qian, Jie Liu, Wei Li, Yongqian Shu
BACKGROUND: Krüppel-like factors (KLFs) have been identified in multi-cancers and act as oncogenes or tumor suppressors. The function of KLF15, one member of KLFs, has not been well elucidated, especially in gastric cancer (GC). AIMS: This study was designed to investigate the prognostic value and biological functions of KLF15 in GC. METHODS: KLF15 protein expression in GC patients was evaluated by immunohistochemistry assays in 50 paired GC tissues and adjacent normal tissues, and correlations between KLF15 expression and clinicopathological characteristics and prognosis were analyzed...
June 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28400202/genetic-variation-in-kruppel-like-factor-15-is-associated-with-left-ventricular-hypertrophy-in-patients-with-type-2-diabetes-discovery-and-replication-cohorts
#15
Sheila K Patel, Bryan Wai, Chim C Lang, Daniel Levin, Colin N A Palmer, Helen M Parry, Elena Velkoska, Stephen B Harrap, Piyush M Srivastava, Louise M Burrell
Left ventricular (LV) hypertrophy (LVH) is a heritable trait that is common in type 2 diabetes and is associated with the development of heart failure. The transcriptional factor Kruppel like factor 15 (KLF15) is expressed in the heart and acts as a repressor of cardiac hypertrophy in experimental models. This study investigated if KLF15 gene variants were associated with LVH in type 2 diabetes. In stage 1 of a 2-stage approach, patients with type 2 diabetes and no known cardiac disease were prospectively recruited for a transthoracic echocardiographic assessment (Melbourne Diabetes Heart Cohort) (n=318) and genotyping of two KLF15 single nucleotide polymorphisms (SNPs) (rs9838915, rs6796325)...
April 2017: EBioMedicine
https://www.readbyqxmd.com/read/28388563/benzene-and-its-metabolite-decreases-cell-proliferation-via-lncrna-obfc2a-mediated-anti-proliferation-effect-involving-notch1-and-klf15
#16
Pengling Sun, Jing Wang, Xiaoli Guo, Yujiao Chen, Caihong Xing, Ai Gao
LncRNA has been considered to play a crucial role in the progression of several diseases by affecting cell proliferation. However, its role in benzene toxicity remains unclear. Our study showed that the expression of lncRNA-OBFC2A increased accompanied with the change of cell proliferation related-genes in benzene-exposed workers. In vitro experiments, 1,4-Benzoquinone dose-dependently inhibited cell proliferation and simultaneously caused the decrease of NOTCH1 expression and the increase of KLF15 in AHH-1 cell lines...
June 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28375666/glucocorticoid-receptor-chip-seq-identifies-plcd1-as-a-klf15-target-that-represses-airway-smooth-muscle-hypertrophy
#17
Sarah K Sasse, Vineela Kadiyala, Thomas Danhorn, Reynold A Panettieri, Tzu L Phang, Anthony N Gerber
Glucocorticoids exert important therapeutic effects on airway smooth muscle (ASM), yet few direct targets of glucocorticoid signaling in ASM have been definitively identified. Here, we show that the transcription factor, Krüppel-like factor 15 (KLF15), is directly induced by glucocorticoids in primary human ASM, and that KLF15 represses ASM hypertrophy. We integrated transcriptome data from KLF15 overexpression with genome-wide analysis of RNA polymerase (RNAP) II and glucocorticoid receptor (GR) occupancy to identify phospholipase C delta 1 as both a KLF15-regulated gene and a novel repressor of ASM hypertrophy...
August 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28336438/klf15-protects-against-isoproterenol-induced-cardiac-hypertrophy-via-regulation-of-cell-death-and-inhibition-of-akt-mtor-signaling
#18
Li Gao, Yudong Guo, Xiaofeng Liu, Deya Shang, Yongjian Du
Increasing evidence indicate that the Krüppel-like factor KLF15, a member of Cys2/His2 zinc-finger DNA-binding proteins, attenuates cardiac hypertrophy. However, the role of KLF15 in cardiovascular system is largely unknown and the exact molecular mechanism of its protective function is not fully elucidated. In the present study, we established a mouse model of cardiac hypertrophy and found that KLF15 expression was down-regulated in hypertrophic hearts. To evaluate the roles of KLF15 in cardiac hypertrophy, we generated transgenic mice overexpressing KLF15 of KLF15 knockdown mice and subsequently induced cardiac hypertrophy...
May 20, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28320523/roles-of-fluid-shear-stress-and-retinoic-acid-in-the-differentiation-of-primary-cultured-human-podocytes
#19
Seung Hee Yang, Jin Woo Choi, Dongeun Huh, Hyung Ah Jo, Sejoong Kim, Chun Soo Lim, Jung Chan Lee, Hee Chan Kim, Hyug Moo Kwon, Chang Wook Jeong, Cheol Kwak, Kwon Wook Joo, Yon Su Kim, Dong Ki Kim
Due to the distinct features that distinguish immortalized podocyte cell lines from their in vivo counterparts, primary cultured human podocytes might be a superior cell model for glomerular disease studies. However, the podocyte de-differentiation that occurs in culture remains an unresolved problem. Here, we present a method to differentiate primary cultured podocytes using retinoic acid (RA) and fluid shear stress (FSS), which mimic the in vivo environment of the glomerulus. RA treatment induced changes in the cell shape of podocytes from a cobblestone-like morphology to an arborized configuration with enhanced mobility...
May 1, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28090143/acute-exercise-regulates-adipogenic-gene-expression-in-white-adipose-tissue
#20
Y Shen, H Zhou, W Jin, H J Lee
White adipose tissue expansion is associated with both hypertrophy and hyperplasia of adipocytes. Exercise training results in adipocyte hypotrophy by activating lipolysis, but it is poorly understood whether exercise regulates adipogenesis by altering adipogenic gene expression. The purpose of this study was to evaluate the effect of a single bout of swimming exercise on adipogenic gene expression in white adipose tissue (WAT). Male C57BL/6J mice were divided into two groups: a sedentary control group and a 120-minute swimming exercise group...
December 2016: Biology of Sport
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