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https://www.readbyqxmd.com/read/29793095/sex-hormones-affect-acute-and-chronic-stress-responses-in-sexually-dimorphic-patterns-consequences-for-depression-models
#1
Lei Guo, Yi-Xi Chen, Yu-Ting Hu, Xue-Yan Wu, Yang He, Juan-Li Wu, Man-Li Huang, Matthew Mason, Ai-Min Bao
BACKGROUND: Alterations in peripheral sex hormones may play an important role in sex differences in terms of stress responses and mood disorders. It is not yet known whether and how stress-related brain systems and brain sex steroid levels fluctuate in relation to changes in peripheral sex hormone levels, or whether the different sexes show different patterns. We aimed to investigate systematically, in male and female rats, the effect of decreased circulating sex hormone levels following gonadectomy on acute and chronic stress responses, manifested as changes in plasma and hypothalamic sex steroids and hypothalamic stress-related molecules...
May 21, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29793048/dna-methylation-differences-at-the-glucocorticoid-receptor-gene-in-depression-are-related-to-functional-alterations-in-hypothalamic-pituitary-adrenal-axis-activity-and-to-early-life-emotional-abuse
#2
Chloё Farrell, Kelly Doolin, Niamh O' Leary, Chaitra Jairaj, Darren Roddy, Leonardo Tozzi, Derek Morris, Andrew Harkin, Thomas Frodl, Zsófia Nemoda, Moshe Szyf, Linda Booij, Veronica O'Keane
Depression is associated with alterations in hypothalamic-pituitary-adrenal (HPA) axis activity. A proposed mechanism to explain these alterations are changes in DNA methylation levels, secondary to early life adversity (ELA), at stress-related genes. Two gene regions that have been implicated in the literature, the glucocorticoid receptor gene (NR3C1) exon 1F and the FKBP5 gene intron 7 were examined in 67 individuals (33 depressed patients and 34 controls). We investigated whether cortisol concentrations, evaluated in 25 depressed patients and 20 controls, and measures of ELA were associated with the degree of methylation at these candidate gene regions...
May 8, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29792595/brg1-governs-glucocorticoid-receptor-interactions-with-chromatin-and-pioneer-factors-across-the-genome
#3
Jackson A Hoffman, Kevin W Trotter, James M Ward, Trevor K Archer
The Glucocorticoid Receptor (GR) alters transcriptional activity in response to hormones by interacting with chromatin at GR binding sites (GBSs) throughout the genome. Our work in human breast cancer cells identifies three classes of GBSs with distinct epigenetic characteristics and reveals that BRG1 interacts with GBSs prior to hormone exposure. The GBSs pre-occupied by BRG1 are more accessible and transcriptionally active than other GBSs. BRG1 is required for a proper and robust transcriptional hormone response and knockdown of BRG1 blocks recruitment of the pioneer factors FOXA1 and GATA3 to GBSs...
May 24, 2018: ELife
https://www.readbyqxmd.com/read/29792225/correction-to-lifetime-stress-accelerates-epigenetic-aging-in-an-urban-african-american-cohort-relevance-of-glucocorticoid-signaling
#4
Anthony S Zannas, Janine Arloth, Tania Carrillo-Roa, Stella Iurato, Simone Röh, Kerry J Ressler, Charles B Nemeroff, Alicia K Smith, Bekh Bradley, Christine Heim, Andreas Menke, Jennifer F Lange, Tanja Brückl, Marcus Ising, Naomi R Wray, Angelika Erhardt, Elisabeth B Binder, Divya Mehta
Upon publication of the original article [1] it was highlighted by the authors that a transposition error affected Additional file 1, causing the misplacement of several columns and rendering the table difficult to read. This transposition does not influence any of the results nor analyses presented in the paper and has since been formally noted in this correction article; the corrected file is available here as an Additional File. The publisher apologizes for this error.
May 23, 2018: Genome Biology
https://www.readbyqxmd.com/read/29791662/graves-ophthalmopathy-low-dose-dexamethasone-reduces-retinoic-acid-receptor-alpha-gene-expression-in-orbital-fibroblasts
#5
Sarah Santiloni Cury, Miriane Oliveira, Maria Teresa Síbio, Sueli Clara, Renata De Azevedo Melo Luvizotto, Sandro Conde, Edson Nacib Jorge, Vania Dos Santos Nunes, Célia Regina Nogueira, Gláucia Maria Ferreira da Silva Mazeto
OBJECTIVE: Graves' ophthalmopathy (GO) is an autoimmune disease that leads to ocular proptosis caused by fat accumulation and inflammation, and the main treatment is corticosteroid therapy. Retinoid acid receptor-alpha (RARα) seems to be associated with inflammation and adipocyte differentiation. This study aimed to assess the effect of glucocorticoid treatment on orbital fibroblasts of GO patient treated or not with different glucocorticoid doses. MATERIALS AND METHODS: Orbital fibroblasts collected during orbital decompression of a female patient with moderately severe/severe GO were cultivated and treated with 10 nM and 100 nM dexamethasone (Dex)...
May 17, 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29791178/-rare-combination-of-turner-syndrome-and-congenital-adrenal-hyperplasia-with-21-hydroxylase-deficiency-case-report
#6
Ivana Ságová, Matej Stančík, Dušan Pavai, Daniela Kantárová, Anton Vaňuga, Peter Vaňuga
Combination of Turner syndrome (TS) and classic congenital adrenal hyperplasia (CAH) is rare. Globally, the incidence of CAH, autosomal recessive disorder caused by enzyme defect of steroidogenic pathway, is very low (1 : 10 000-16 000). 90 % of CAH cases are caused by 21-hydroxylase gene mutation (CYP21A2). Globally, the incidencie of Turner syndrome reaches 1 : 2 500. Phenotypically, females with TS may render wide spectrum of clinical features. Dominant symptoms are lowered terminal height and gonadal dysgenesia, ultimately leading to absence of puberty and infertility...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29791007/should-all-patients-with-adrenal-insufficiency-or-a-subgroup-of-patients-with-pre-diabetes-be-treated-with-dual-release-hydrocortisone
#7
Roberta Giordano
Guarnotta et al. compare the effects of dual-release (DR) hydrocortisone 36 months' treatment in 13 patients with primary adrenal insufficiency and 36 with secondary adrenal insufficiency, compared to conventional glucocorticoid treatment. A retrospective evaluation was conducted on the effects of 36 months of DR hydrocortisone therapy on visceral adiposity, insulin secretion and insulin sensitivity. Forty-nine patients with adrenal insufficiency were recruited. This article is protected by copyright. All rights reserved...
May 23, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29790583/stress-in-biological-invasions-introduced-invasive-grey-squirrels-increase-physiological-stress-in-native-eurasian-red-squirrels
#8
Francesca Santicchia, Ben Dantzer, Freya van Kesteren, Rupert Palme, Adriano Martinoli, Nicola Ferrari, Lucas Wauters Armand
1.Invasive alien species can cause extinction of native species through processes including predation, interspecific competition for resources, or disease-mediated competition. Increases in stress hormones in vertebrates may be associated with these processes and contribute to the decline in survival or reproduction of the native species. 2.Eurasian red squirrels (Sciurus vulgaris) have gone extinct across much of the British Isles and parts of Northern Italy following the introduction of North American invasive grey squirrels (Sciurus carolinensis)...
May 23, 2018: Journal of Animal Ecology
https://www.readbyqxmd.com/read/29790372/folate-receptor-targeted-mixed-polysialic-acid-micelles-for-combating-rheumatoid-arthritis-in-vitro-and-in-vivo-evaluation
#9
Nan Zhang, Chunyu Xu, Na Li, Shasha Zhang, Lingling Fu, Xiao Chu, Haiying Hua, Xianghui Zeng, Yongxing Zhao
OBJECTIVE: Rheumatoid arthritis (RA) is associated with chronic inflammation. The suppression of inflammation is key to the treatment of RA. Glucocorticoids (GCs) are classical anti-inflammatory drugs with several disadvantages such as poor water solubility and low specificity in the body. These disadvantages are the reasons for the quick elimination and side effects of GCs in vivo. Micelles are ideal carriers for GCs delivery to inflamed synovium. We set out to improve the targeting and pharmacokinetic profiles of GCs by preparing a targeting micelle system...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29790026/pathogenetic-role-of-the-stress-induced-release-of-glucocorticoid-hormones-in-the-development-of-post-traumatic-stress-disorder-an-experimental-study
#10
M Y Zenko, K A Baranova, E A Rybnikova
In the rat experimental model of posttraumatic stress disorder (PTSD), the level of blood corticosterone was at least eight-fold increased (an overrelease). The use of hypobaric hypoxic preconditioning or short-term inhibition of glucocorticoid synthesis by metyrapone injection prevented development of the experimental PTSD.
March 2018: Doklady Biological Sciences: Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections
https://www.readbyqxmd.com/read/29789551/epidermal-glucocorticoid-and-mineralocorticoid-receptors-act-cooperatively-to-regulate-epidermal-development-and-counteract-skin-inflammation
#11
Judit Bigas, Lisa M Sevilla, Elena Carceller, Julia Boix, Paloma Pérez
Endogenous and synthetic glucocorticoids (GCs) regulate epidermal development and combat skin inflammatory diseases. GC actions can be mediated through the GC receptor (GR) and/or the mineralocorticoid receptor (MR), highly homologous ligand-activated transcription factors. While the role of GR as a potent anti-inflammatory mediator is well known, that of MR is not as clear, nor is whether these receptors cooperate or antagonize each other in the epidermis. To address this, we generated mice with epidermal-specific loss of both receptors (double knockout, DKO), and analyzed the phenotypical and functional consequences relative to single KOs or controls (CO)...
May 22, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29788810/clinical-and-immunological-pattern-and-outcome-of-egyptian-systemic-lupus-erythematosus-patients-a-single-center-experience
#12
G A Mahmoud, A A Shahin, H S Zayed, A Moghazy, B M Eissa
Objective The objective of this study was to describe the clinical and immunological pattern and disease outcome in Egyptian systemic lupus erythematosus patients. Patients and methods The medical records of 770 systemic lupus erythematosus patients who were followed from 2002-2015 at Kasr Alainy Hospital, Cairo University, were retrospectively reviewed. Results There were 707 (91.8%) females. The mean age at disease onset was 22.1 ± 8.6 and the disease duration was 6.1 ± 4.5 years. The main clinical manifestations were mucocutaneous (90...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29788546/in-vitro-penetration-through-the-skin-layers-of-topically-applied-glucocorticoids
#13
Victor Carrer, Cristina Alonso, Marc Adrià Oliver, Luisa Coderch
Corticoids are actives widely used in the treatment of skin diseases. This work aims to study the penetration of three corticoids (betamethasone, clobetasol and flurandrenolide), their relationship with their Log D values and the effects of the vehicles. The three compounds were applied on a Franz-type diffusion cell in propylene glycol solution and their respective commercial creams and ointments. The active amounts found in the stratum corneum, epidermal and dermal layers of the skin were investigated. Their diffusions were greatly affected by the formulation, moreover higher amounts of substance in the epidermis and dermis were detected in ointments than in creams...
May 22, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29788135/the-hepatic-glucocorticoid-receptor-is-crucial-for-cortisol-homeostasis-and-sepsis-survival-in-humans-and-male-mice
#14
Marc Jenniskens, Ruben Weckx, Thomas Dufour, Sarah Vander Perre, Lies Pauwels, Sarah Derde, Arno Téblick, Fabian Güiza, Greet Van den Berghe, Lies Langouche
Sepsis is hallmarked by hypercortisolemia, a stress response that is essential for survival. This elevation in plasma cortisol is partially brought about by suppressed hepatic cortisol breakdown. We now demonstrated that a controlled downregulation of the hepatic glucocorticoid receptor (hepatic GR) is crucial herein. In a mouse model of fluid-resuscitated, antibiotic-treated abdominal sepsis and in human ICU patients, sepsis reduced hepatic GR expression and signaling, but increased (free) plasma cortisol/corticosterone, explained by suppressed cortisol/corticosterone binding proteins and A-ring-reductases...
May 17, 2018: Endocrinology
https://www.readbyqxmd.com/read/29787791/pathogen-dependent-modulation-of-milk-neutrophils-competence-plasma-inflammatory-cytokines-and-milk-quality-during-intramammary-infection-of-sahiwal-bos-indicus-cows
#15
Mohanned Naif Alhussien, Ajay Kumar Dang
The aim of the current study was to investigate the responses of milk neutrophils and plasma inflammatory cytokines to various mastitis pathogens and subsequently on milk composition. Milk was collected from healthy (n = 10) and clinical mastitis indigenous Sahiwal cows naturally infected either with gram-positive bacteria mainly S. aureus (n = 10) and Strep. agalactiae (n = 10) or with gram-negative bacteria, E. coli (n = 10). Phagocytic activity of milk neutrophils decreased in all mastitis cows with the lowest values recorded during gram-positive bacterial infections...
May 19, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29787416/cecal-ligation-and-puncture-alters-glucocorticoid-receptor-expression
#16
Mabel N Abraham, Daniela M Jimenez, Tiago D Fernandes, Clifford S Deutschman
OBJECTIVES: Interventional trials on glucocorticoids in sepsis have yielded capricious results. Recent studies have identified multiple glucocorticoid receptor isoforms. The relative abundance of these isoforms in septic patients and following murine cecal ligation and puncture is unknown. The objective of this study is to determine the effects of cecal ligation and puncture on glucocorticoid receptor isoform abundance. DESIGN: Determination of effects of cecal ligation and puncture on glucocorticoid receptor isoform subtype abundance in C57BL/6 mice...
May 21, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29786884/bone-morbidity-and-recovery-in-children-with-acute-lymphoblastic-leukemia-results-of-a-six-year-prospective-cohort-study
#17
Leanne M Ward, Jinhui Ma, Bianca Lang, Josephine Ho, Nathalie Alos, Mary Ann Matzinger, Nazih Shenouda, Brian Lentle, Jacob L Jaremko, Beverly Wilson, David Stephure, Robert Stein, Anne Marie Sbrocchi, Celia Rodd, Victor Lewis, Sara Israels, Ronald M Grant, Conrad V Fernandez, David B Dix, Elizabeth A Cummings, Robert Couch, Elizabeth Cairney, Ronald Barr, Sharon Abish, Stephanie A Atkinson, John Hay, Frank Rauch, David Moher, Kerry Siminoski, Jacqueline Halton
Osteoporotic fractures are a significant cause of morbidity in acute lymphoblastic leukemia (ALL). Our objective was to determine the incidence and predictors of fractures and recovery from osteoporosis in pediatric ALL over 6 years following glucocorticoid initiation. Vertebral fractures (VF) and vertebral body reshaping were assessed on annual spine radiographs, low-trauma non-VF were recorded at regular intervals and spine bone mineral density (BMD) was captured every 6 months for 4 years and then annually...
May 22, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29786693/hormonebase-a-population-level-database-of-steroid-hormone-levels-across-vertebrates
#18
Maren N Vitousek, Michele A Johnson, Jeremy W Donald, Clinton D Francis, Matthew J Fuxjager, Wolfgang Goymann, Michaela Hau, Jerry F Husak, Bonnie K Kircher, Rosemary Knapp, Lynn B Martin, Eliot T Miller, Laura A Schoenle, Jennifer J Uehling, Tony D Williams
Hormones are central regulators of organismal function and flexibility that mediate a diversity of phenotypic traits from early development through senescence. Yet despite these important roles, basic questions about how and why hormone systems vary within and across species remain unanswered. Here we describe HormoneBase, a database of circulating steroid hormone levels and their variation across vertebrates. This database aims to provide all available data on the mean, variation, and range of plasma glucocorticoids (both baseline and stress-induced) and androgens in free-living and un-manipulated adult vertebrates...
May 22, 2018: Scientific Data
https://www.readbyqxmd.com/read/29786138/association-of-different-immunosuppressive-medications-with-periodontal-condition-in-patients-with-rheumatoid-arthritis-results-from-a-cross-sectional-study
#19
Dirk Ziebolz, Annegret Rupprecht, Jan Schmickler, Laura Bothmann, Juliane Krämer, Daniel Patschan, Gerhard A Müller, Rainer F Mausberg, Jana Schmidt, Gerhard Schmalz, Susann Patschan
BACKGROUND: The aim of this cross-sectional study was to investigate clinical periodontal findings as well as prevalence of selected potentially periodontal pathogenic bacteria in patients with rheumatoid arthritis (RA) treated with different immunosuppressive rheumatic medications. METHODS: 168 patients with RA undergoing different immunosuppressive medications were included and divided into subgroups according to their medication, which was taken in the past six months, in detail I) non-steroidal anti-inflammatory drugs (NSAID) and glucocorticoids combined, and II-VII) different disease modifying anti-rheumatic drugs (DMARDs): II) Methotrexate (MTX), III) Leflunomide, IV) MTX and TNF-α antagonists combined, V) Interleukin-6 (IL-6) antagonist, VI) MTX and Rituximab combined, and VII) combination therapies of more than two of these DMARDs...
May 22, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29786049/lipoxin-a4-ameliorates-lipopolysaccharide-induced-a549-cell-injury-through-upregulation-of-n-myc-downstream-regulated-gene-1
#20
Jun-Zhi Zhang, Zhan-Li Liu, Yao-Xian Zhang, Hai-Jiu Lin, Zhong-Jun Zhang
Background: Lipoxin A4 (LXA4) can alleviate lipopolysaccharide (LPS)-induced acute lung injury (ALI) and acute respiratory distress syndrome through promoting epithelial sodium channel (ENaC) expression in lung epithelial cells. However, how LXA4 promote ENaC expression is still largely elusive. The present study aimed to explore genes and signaling pathway involved in regulating ENaC expression induced by LXA4. Methods: A549 cells were incubated with LPS and LXA4, or in combination, and analyzed by quantitative real-time polymerase chain reaction (qRT-PCR) of ENaC-α/γ...
June 5, 2018: Chinese Medical Journal
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