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Sterotactic body

Jing Zeng, Christina Baik, Shailender Bhatia, Nina Mayr, Ramesh Rengan
Recent advances allow safe and effective delivery of ablative doses of radiation with stereotactic precision to tumours, resulting in very high levels of tumour control. Parallel advances in the understanding of tumour biology enable delivery of systemic drugs that selectively antagonise biological pathways in the tumour and surrounding microenvironment. Data is emerging that these treatments have synergistic effects that might further increase therapeutic efficacy, and they are therefore being increasingly used in combination, primarily in metastatic or recurrent disease...
September 2014: Lancet Oncology
Fiona McMurray, Chris D Church, Rachel Larder, George Nicholson, Sara Wells, Lydia Teboul, Y C Loraine Tung, Debra Rimmington, Fatima Bosch, Veronica Jimenez, Giles S H Yeo, Stephen O'Rahilly, Frances M Ashcroft, Anthony P Coll, Roger D Cox
The strongest BMI-associated GWAS locus in humans is the FTO gene. Rodent studies demonstrate a role for FTO in energy homeostasis and body composition. The phenotypes observed in loss of expression studies are complex with perinatal lethality, stunted growth from weaning, and significant alterations in body composition. Thus understanding how and where Fto regulates food intake, energy expenditure, and body composition is a challenge. To address this we generated a series of mice with distinct temporal and spatial loss of Fto expression...
2013: PLoS Genetics
E Champeaux-Orange, T Wachter, H Bouscayrol, I Barillot
PURPOSE: Surgery is the main treatment of early stage non small cell lung cancer. However, in inoperable patients, the treatment is usually conventional radiotherapy. Results are poor and acute toxicity is severe. Stereotactic body radiation therapy provides better results in terms of local control and toxicity. Our purpose was to evaluate the clinical outcomes of patients with primary lung tumours treated by stereotactic body radiation therapy using a stereotactic body frame at the Orléans Regional Hospital...
June 2011: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
T Egelhof, N Delbeck, M Hartmann, S U Roth, V Elste, S Heiland, K Sartor
PURPOSE: To investigate whether the margins of microscopic tumors can be delineated better with monocrystalline iron oxide nanoparticles (MION), a superparamagnetic contrast medium, than with Gd-DTPA by magnetic resonance imaging (MRI). METHODS: MRI and histological examinations were conducted in 28 Wistar rats with sterotactically implanted gliomas (C6 gliomas). Of the 28 animals, 14 were examined after intravenous administration of MION [nine animals received 179 mmol Fe/kg body weight (dose 1), and five, 893 mmol Fe/kg (dose 2)]...
November 1998: Der Radiologe
B B Mittal
This article focuses on a number of innovative radiotherapeutic methods to improve local and regional control with increased chances of preservation of normal function compared with the use of standard external beam irradiation alone in the management of selected head and neck cancers. Some of these radiotherapeutic techniques are well established (brachytherapy and neutron therapy in advanced salivary gland tumors); some have a large body of experience accumulated and are currently being investigated in phase III trials (thermoradiotherapy and altered fractionation); whereas the other techniques (intraoperative therapy, charged-particle therapy, and sterotactic radiosurgery) are highly experimental...
December 1991: Otolaryngologic Clinics of North America
D J Blake, P Zarzecki, G G Somjen
The potential waves evoked in the caudate nucleus (CN) of cats by stimulation of the cerebral neocortex were sterotactically recorded. The head and the body of the caudate nucleus were systematically explored. Stimulation of the ipsilateral sigmoid gyrus and the orbitofrontal cortex evoked waves with the largest amplitude in the CN. Smaller potentials were evoked from the ipsilateral ectosylvian and suprasylvian gyri and from the sigmoid gyrus on the contralateral side. Antidromic conduction from the caudate nucleus to the cortex demonstrated the directness of the corticocaudate pathway...
March 1976: Journal of Neurobiology
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