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Stereotactic ablative

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https://www.readbyqxmd.com/read/29227251/-stereotactic-thalamotomy-and-contralateral-subthalamotomy-in-treatment-of-parkinson-s-disease
#1
K Kostiuk, V Lomadze, N Vasyliv
Aim - to evaluate the efficacy of combined bilateral stereotactic destruction of subcortical nucleus - thalamotomy and contralateral subthalamotomy in patients with Parkinson disease. The study included 10 patients with PD, aged 54-73 (mean age 61.1±5.2 years). The time between two surgeries ranged from 1 to 5 years (mean 2.5±0.5 years). The surgeries were conducted on CRW Radionics stereotactic system using StereoPlan, Atlas (Radionics) andFraimLink (Medtronic) software for target calculating. The neuropsychological status was assessed by UPDRS II, Hoehn and Yahr scale, Schwab and England scale, MMSE...
November 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29226093/complete-biochemical-response-after-stereotactic-ablative-radiotherapy-of-an-isolated-prostate-cancer-pelvic-soft-tissue-recurrence-detected-by-18f-dcfpyl-pet-ct
#2
Ryan M Phillips, Michael A Gorin, Steven P Rowe, Martin G Pomper, Kenneth J Pienta, Ashley E Ross, Phuoc T Tran
No abstract text is available yet for this article.
January 2018: Urology Case Reports
https://www.readbyqxmd.com/read/29224900/single-fraction-stereotactic-ablative-body-radiotherapy-for-oligometastasis-outcomes-from-132-consecutive-patients
#3
S Gandhidasan, D Ball, T Kron, M Bressel, M Shaw, J Chu, S Chander, G Wheeler, N Plumridge, B Chesson, S David, S Siva
AIMS: Stereotactic ablative body radiotherapy (SABR) is currently used to treat oligometastases, but the optimum dose/fractionation schedule is unknown. In this study, we evaluated outcomes after single fraction SABR in patients with oligometastatic disease. MATERIALS AND METHODS: Single institutional retrospective review of patients treated with single fraction SABR for one to three oligometastases between 2010 and 2015. The primary outcome was freedom from widespread disease defined as distant recurrence not amenable to surgery or SABR; or recurrence with four or more metastases...
December 7, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29208438/an-integrated-multidisciplinary-algorithm-for-the-management-of-spinal-metastases-an-international-spine-oncology-consortium-report
#4
REVIEW
Daniel E Spratt, Whitney H Beeler, Fabio Y de Moraes, Laurence D Rhines, Joseph J Gemmete, Neeraj Chaudhary, David B Shultz, Sean R Smith, Alejandro Berlin, Max Dahele, Ben J Slotman, Kelly C Younge, Mark Bilsky, Paul Park, Nicholas J Szerlip
Spinal metastases are becoming increasingly common because patients with metastatic disease are living longer. The close proximity of the spinal cord to the vertebral column limits many conventional therapeutic options that can otherwise be used to treat cancer. In response to this problem, an innovative multidisciplinary approach has been developed for the management of spinal metastases, leveraging the capabilities of image-guided stereotactic radiosurgery, separation surgery, vertebroplasty, and minimally invasive local ablative approaches...
December 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29205797/stereotactic-ablative-radiotherapy-for-hepatocellular-carcinoma-history-current-status-and-opportunities
#5
REVIEW
Jeffrey Meyer, Amit G Singal
A variety of surgical and other local-regional approaches to the management of hepatocellular carcinoma are in clinical use. External beam radiation therapy is a relative newcomer to the portfolio of treatment options. Advances in planning and delivery of radiation therapy, developing in parallel with and inspiring changing paradigms of tumor management in the field of radiation oncology, have led to growing interest in radiation therapy as a viable treatment option for hepatocellular carcinoma as well as other liver tumors...
December 5, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/29205634/safety-and-feasibility-of-stereotactic-radiotherapy-using-computed-portal-radiography-for-canine-intracranial-tumors
#6
Nicholas J Rancilio, R Timothy Bentley, Jeannie Poulson Plantenga, Magdalena M Parys, Beatriz G Crespo, George E Moore
Stereotactic radiotherapy is a highly conformal treatment option for intracranial and extracranial malignancies. Stereotactic radiotherapy utilizes specialized equipment specifically designed to avoid normal tissue while delivering ablative treatments with submillimeter precision and accuracy. Linear accelerator based stereotactic radiotherapy incorporates on-board image guidance utilizing cone beam computed tomography (CT). Many institutions lack the ability to provide image guidance with cone beam CT but delivery of highly conformal treatments with submillimeter precision and accuracy is still feasible...
December 4, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29203153/focused-ultrasound-subthalamotomy-in-patients-with-asymmetric-parkinson-s-disease-a-pilot-study
#7
Raul Martínez-Fernández, Rafael Rodríguez-Rojas, Marta Del Álamo, Frida Hernández-Fernández, Jose A Pineda-Pardo, Michele Dileone, Fernando Alonso-Frech, Guglielmo Foffani, Ignacio Obeso, Carmen Gasca-Salas, Esther de Luis-Pastor, Lydia Vela, José A Obeso
BACKGROUND: Ablative neurosurgery has been used to treat Parkinson's disease for many decades. MRI-guided focused ultrasound allows focal lesions to be made in deep brain structures without skull incision. We investigated the safety and preliminary efficacy of unilateral subthalamotomy by focused ultrasound in Parkinson's disease. METHODS: This prospective, open-label pilot study was done at CINAC (Centro Integral de Neurociencias), University Hospital HM Puerta del Sur in Madrid, Spain...
December 1, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/29200112/epidemiology-treatment-and-complications-of-central-nervous-system-metastases
#8
Amy A Pruitt
PURPOSE OF REVIEW: Neurologic problems resulting from systemic cancer metastases to brain parenchyma, dura, spinal cord, and leptomeninges are among the most common types of consultations addressed by neurologists. With patients surviving longer from systemic cancer, along with the rapidly evolving therapeutic options, the treatment of these devastating complications has become both more effective and more complicated. This article reviews current patterns of metastatic disease and the increasingly nuanced landscape of evolving therapies, their complications, and their impact on quality of survival...
December 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/29196082/feasible-optimization-of-stereotactic-ablative-radiotherapy-dose-by-tumor-size-for-stage-i-non-small-cell-lung-cancer
#9
Sumin Lee, Si Yeol Song, Su Ssan Kim, Wonsik Choi, Hyoung Uk Je, Geum Mun Back, Byungchul Cho, Seong-Yun Jeong, Eun Kyung Choi
INTRODUCTION: The purpose of this study was to assess the effect of dose escalation of stereotactic ablative radiotherapy (SABR) by investigating the long-term clinical outcomes of SABR for stage I non-small-cell lung cancer (NSCLC). METHODS: A retrospective analysis was performed on a total of 169 patients with 178 lesions of stage I NSCLC treated with SABR at a single institution from June 2000 to May 2015. The standard dose scheme for SABR was 48 Gy in 4 fractions during the early period of the analysis, but it was escalated to 60 Gy in 4 fractions from June 2009...
November 14, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29194510/correlation-of-biologically-effective-dose-and-the-tumor-control-in-stage-i-5-cm-non-small-cell-lung-cancer-with-stereotactic-ablative-radiotherapy-a-single-institutional-cohort-study
#10
Wan Jeon, Sung-Ja Ahn, Young-Chul Kim, In-Jae Oh, Chul-Kyu Park, Jae-Uk Jeong, Mee Sun Yoon, Ju-Young Song, Taek-Keun Nam, Woong-Ki Chung
Backgrounds: Stereotactic ablative radiotherapy (SABR) is one of the newly developed innovative radiotherapy and of which optimal dose prescription needs to be standardized. We aimed to investigate the dose-response relationship for patients with SABR. Methods: Fifty-three patients with Stage I non-small cell lung cancer patients, who underwent SABR between November 2006 and January 2015, were evaluated retrospectively. Thirteen patients (24.5%), who refused the surgery were included and 40 patients (75...
November 29, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29191586/outcome-of-radical-local-treatment-of-non-small-cell-lung-cancer-patients-with-synchronous-oligometastases
#11
Margriet Kwint, Iris Walraven, Sjaak Burgers, Koen Hartemink, Houke Klomp, Joost Knegjens, Marcel Verheij, José Belderbos
OBJECTIVES: Patients with stage IV non-small cell lung cancer (NSCLC) are considered incurable and are mainly treated with palliative intent. This patient group has a poor overall survival (OS) and progression free survival (PFS). The purpose of this study was to investigate PFS and OS of NSCLC patients diagnosed with synchronous oligometastatic disease who underwent radical treatment of both intrathoracic disease and metastases. MATERIALS AND METHODS: Patients with NSCLC and oligometastatic disease at diagnosis, who were treated with radical intent between 2008 and 2016, were included in this observational study...
October 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29191470/optimal-beam-margins-in-linac-based-vmat-stereotactic-ablative-body-radiotherapy-a-pareto-front-analysis-for-liver-metastases
#12
Savino Cilla, Anna Ianiro, Francesco Deodato, Gabriella Macchia, Cinzia Digesù, Vincenzo Valentini, Alessio G Morganti
We explored the Pareto fronts mathematical strategy to determine the optimal block margin and prescription isodose for stereotactic body radiotherapy (SBRT) treatments of liver metastases using the volumetric-modulated arc therapy (VMAT) technique. Three targets (planning target volumes [PTVs] = 20, 55, and 101 cc) were selected. A single fraction dose of 26 Gy was prescribed (prescription dose [PD]). VMAT plans were generated for 3 different beam energies. Pareto fronts based on (1) different multileaf collimator (MLC) block margin around PTV and (2) different prescription isodose lines (IDL) were produced...
November 27, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29189331/ablative-radiotherapy-doses-for-locally-advanced-pancreatic-cancer-lapc
#13
Christopher H Crane, Eileen M O'Reilly
Standard palliative doses of radiation for locally advanced unresectable pancreatic cancer have had minimal to no impact on survival. Randomized trials evaluating these palliative doses have not shown a significant survival benefit with the use of radiation as consolidation after chemotherapy. Results from nonrandomized studies of 3- to 5-fraction low-dose stereotactic radiation (SBRT) have likewise had a minimal impact, but with less toxicity and a shorter treatment time. Doses of SBRT have been reduced to half the level that is necessary (biological equivalent dose, BED of 53 Gy) to achieve tumor ablation in the treatment of other solid tumors (100 Gy BED) to protect the gastrointestinal (GI) tract...
November 2017: Cancer Journal
https://www.readbyqxmd.com/read/29183959/stereotactic-eeg-guided-laser-interstitial-thermal-therapy-for-mesial-temporal-lobe-epilepsy
#14
James X Tao, Shasha Wu, Maureen Lacy, Sandra Rose, Naoum P Issa, Carina W Yang, Katherine E Dorociak, Maria Bruzzone, Jisoon Kim, Ahmad Daif, Jason Choi, Vernon L Towle, Peter C Warnke
OBJECTIVE: To determine the outcomes of combined stereo-electroencephalography-guided and MRI-guided stereotactic laser interstitial thermal therapy (LITT) in the treatment of patients with drug-resistant mesial temporal lobe epilepsy (mTLE). METHODS: We prospectively assessed the surgical and neuropsychological outcomes in 21 patients with medically refractory mTLE who underwent LITT at the University of Chicago Medical Center. We further compared the surgical outcomes in patients with and without mesial temporal sclerosis (MTS)...
November 28, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29172137/the-impact-of-stereotactic-laser-ablation-at-a-typical-epilepsy-center
#15
Gabrielle T Petito, Robert E Wharen, Anteneh M Feyissa, Sanjeet S Grewal, John A Lucas, William O Tatum
PURPOSE: Stereotactic laser ablation (SLA) is a novel form of epilepsy surgery for patients with drug-resistant focal epilepsy. We evaluated one hundred consecutive surgeries performed for patients with epilepsy to address the impact of SLA on our therapeutic approach, as well as patient outcomes. METHODS: A retrospective, single center analysis of the last one hundred neurosurgeries for epilepsy was performed from 2013 to 2015. Demographics, surgical procedures, and postoperative measures were assessed up to 5years to compare the effect of SLA on outcome...
November 21, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29162055/stereotactic-body-radiotherapy-sbrt-for-locally-advanced-intrahepatic-and-extrahepatic-cholangiocarcinoma
#16
Eleni Gkika, Lukas Hallauer, Simon Kirste, Sonja Adebahr, Nico Bartl, Hannes Philipp Neeff, Ralph Fritsch, Volker Brass, Ursula Nestle, Anca Ligia Grosu, Thomas Baptist Brunner
BACKGROUND: To evaluate the role of ablative radiotherapy doses in the treatment of hilar or intrahepatic cholangiocarcinoma (CCC) using stereotactic body radiotherapy (SBRT). METHODS: Consecutive patients treated from 2007 to 2016 with CCC were evaluated. Local control and toxicities were assessed every 3 months according to the Response Evaluation Criteria In Solid Tumors (RECIST) and the Common Terminology Criteria for Adverse Events v4.0, respectively. Overall survival (OS), local control (LC) and progression free survival were calculated from SBRT...
November 21, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29158591/surgical-oncology-for-gliomas-the-state-of-the-art
#17
REVIEW
Nader Sanai, Mitchel S Berger
Surgical resection remains the mainstay of treatment for patients with glioma of any grade. Maximal resection of the tumour is central to achieving long-term disease control; however, the relationship between the extent of glioma resection and actual clinical benefit for the patient is predicated on the balance between cytoreduction and neurological morbidity. For the neurosurgical oncologist, the clinical rationale for undertaking increasingly extensive resections has gained traction. In parallel, novel surgical techniques and technologies have been developed that help improve patient outcomes...
November 21, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/29155507/the-role-of-radiation-therapy-in-the-modern-management-of-oligometastatic-disease
#18
Yan Li, Suyu Tao, Mengru Li, Duojie Li
Multimodal treatment approaches are indispensable for patients with advanced-stage cancer, while radiation therapy has been established as essential part of therapeutic approaches and has been introduced as a better option to face challenges, such as, local relapse or oligometastatic disease. The mere insight of the concept of oligometastases, proposed for the first time in the middle 1990s, led to the hypothesis that this condition may be cured using local ablative weapons. This hypothesis has already been demonstrated by surgical ablative techniques...
July 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29155063/technical-note-robotic-guided-bi-hippocampal-and-bi-parahippocampal-depth-placement-for-responsive-neurostimulation-in-bitemporal-lobe-epilepsy
#19
Pratik Rohatgi, Ryan J Jafrani, Nicholas J Brandmeir, Frank G Gilliam, Tiffany L Fisher, Michael D Sather
BACKGROUND: Patients with bitemporal lobe epilepsy are generally not considered for surgical resection. Fortunately, responsive neurostimulation proves another avenue for the management of this challenging disease process. In conjunction with our epileptologist, we consider responsive neurostimulation for patients who have clinical features of temporal lobe epilepsy without clear localization on imaging and stereo-EEG. METHODS: Here we describe our technique for implanting a responsive neurostimulator (NeuroPace, NeuroPace Inc...
November 14, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29140463/anatomic-investigation-of-the-trajectory-for-stereotactic-laser-amygdalohippocampectomy
#20
Vanessa M Holanda, Abuzer Gungor, Serhat Baydin, Erik H Middlebrooks, Shabbar F Danish
BACKGROUND: Magnetic resonance imaging-guided laser interstitial thermal therapy (LITT) has emerged as a promising treatment for mesial temporal lobe epilepsy. Surgeons must understand the relevant anatomy that is traversed by the catheter and affected by ablation. OBJECTIVE: To study the anatomic structures crossed by the LITT catheter until it reaches the amygdala. METHODS: Three human cadaveric heads were implanted with catheters using a frameless stereotactic technique...
November 11, 2017: Operative Neurosurgery (Hagerstown, Md.)
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