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Stereotactic ablative

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https://www.readbyqxmd.com/read/29467124/gastric-and-duodenal-ischaemia-after-transarterial-chemoembolisation-for-hepatocellular-carcinoma-an-unexpected-but-significant-complication
#1
Sai Pavan Chintalapati, Arpan Patel, Hari Conjeevaram
Transarterial chemoembolisation (TACE) is commonly used for unresectable intermediate-stage hepatocellular carcinoma (HCC). TACE is usually well-tolerated. We report a case of a patient who presented with a gastrointestinal bleed from TACE. A 64-year-old man presented with chronic hepatitis C cirrhosis and multifocal bilobar HCC. He had previously undergone multiple TACE sessions, radiofrequency ablation and stereotactic body radiation therapy. In the evening of his TACE procedure, he developed abdominal pain and haematemesis...
February 21, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29463266/unresectable-hepatic-pecoma-a-rare-malignancy-treated-with-stereotactic-body-radiation-therapy-sbrt-followed-by-complete-resection
#2
Simon Kirste, Gian Kayser, Anne Zipfel, Anca-Ligia Grosu, Thomas Brunner
BACKGROUND: Perivascular epithelioid cell tumors (PEComas) are rare mesenchymal tumors occurring in various anatomic regions. Although diagnostic criteria and treatment management are not established, current treatment options consist of surgery and chemotherapy including mTOR inhibitors. Stereotactic body radiation therapy (SBRT) is a non-invasive ablative treatment which has shown excellent control rates for more common types of unresectable liver tumors and metastases. In this report we present a rare case of PEComa of the liver that was treated by stereotactic radiotherapy followed by resection...
February 20, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29452868/chest-wall-dose-reduction-using-noncoplanar-volumetric-modulated-arc-radiation-therapy-for-lung-stereotactic-ablative-radiation-therapy
#3
Amy S Yu, Peter G Maxim, Billy W Loo, Michael F Gensheimer
PURPOSE: Stereotactic ablative radiation therapy (SABR) to lung tumors close to the chest wall can cause rib fractures or chest wall pain. We evaluated and propose a clinically practical solution of using noncoplanar volumetric modulated arc radiation therapy (VMAT) to reduce chest wall dose from lung SABR. METHODS AND MATERIALS: Twenty lung SABR VMAT plans in which the chest wall volume receiving 30 Gy or higher (V30) exceeded 30 mL were replanned by noncoplanar VMAT with opposite 15° couch kicks...
December 19, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29451455/laser-ablative-therapy-of-sessile-hypothalamic-hamartomas-in-children-using-interventional-mri-report-of-5-cases
#4
Derek G Southwell, Harjus S Birk, Paul S Larson, Philip A Starr, Leo P Sugrue, Kurtis I Auguste
Hypothalamic hamartomas (HHs) are benign lesions that cause medically refractory seizures, behavioral disturbances, and endocrine dysfunction. Open resection of HHs does not guarantee seizure freedom and carries a relatively high risk of morbidity. Minimally invasive stereotactic laser ablation has recently been described as an effective and safe alternative for HH treatment. Prior studies have not, however, assessed HH lesion size and morphology, 2 factors that may influence treatment results and, ultimately, the generalizability of their findings...
February 16, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29451453/trapped-ventricle-after-laser-ablation-of-a-subependymal-giant-cell-astrocytoma-complicated-by-intraventricular-gadolinium-extravasation-case-report
#5
Michael Karsy, Daxa M Patel, Robert J Bollo
Magnetic resonance imaging-guided stereotactic laser ablation of intracranial targets, including brain tumors, has expanded dramatically over the past decade, but there have been few reports of complications, especially those occurring in a delayed fashion. Laser ablation of subependymal giant cell astrocytomas (SEGAs) is an attractive alternative to maintenance immunotherapy in some children with tuberous sclerosis complex (TSC); however, the effect of treatment on disease progression and the nature and frequency of potential complications remains largely unknown...
February 16, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29450589/effect-of-continuous-positive-airway-pressure-administration-during-lung-stereotactic-ablative-radiotherapy-a-comparative-planning-study
#6
Dario Di Perri, Andréa Colot, Antoine Delor, Randa Ghoul, Guillaume Janssens, Valérie Lacroix, Pascal Matte, Annie Robert, Kevin Souris, Xavier Geets
PURPOSE: By increasing lung volume and decreasing respiration-induced tumour motion amplitude, administration of continuous positive airway pressure (CPAP) during stereotactic ablative radiotherapy (SABR) could allow for better sparing of the lungs and heart. In this study, we evaluated the effect of CPAP on lung volume, tumour motion amplitude and baseline shift, as well as the dosimetric impact of the strategy. METHODS: Twenty patients with lung tumours referred for SABR underwent 4D-computed tomography (CT) scans with and without CPAP (CPAP/noCPAP) at two timepoints (T0/T1)...
February 15, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29446317/credentialing-of-radiotherapy-centres-in-australasia-for-trog-09-02-chisel-a-phase-iii-clinical-trial-on-stereotactic-ablative-body-radiotherapy-of-early-stage-lung-cancer
#7
Tomas Kron, Brent Chesson, Nicholas Hardcastle, Melissa Crain, Natalie Clements, Mark Burns, David Ball
OBJECTIVE: A randomised clinical trial comparing Stereotactic Ablative Body Radiotherapy (SABR) with conventional radiotherapy for early stage lung cancer has been conducted in Australia and New Zealand under the auspices of the TransTasman Radiation Oncology Group (NCT01014130). We report on the technical credentialing program as prerequisite for centres joining the trial. METHODS: Participating centres were asked to develop treatment plans for two test cases to assess their ability to create plans according to protocol...
February 15, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29444286/techniques-to-ensure-accurate-targeting-for-delivery-of-awake-laser-interstitial-thermotherapy
#8
Dimitri Laurent, Seth F Oliveria, Michael Shang, Frank Bova, Rachel Freedman, Maryam Rahman
BACKGROUND: Magnetic resonance imaging (MRI) guided laser interstitial thermal therapy (LITT) is an emerging neurosurgical treatment modality that is typically performed under general anesthesia. We describe a novel workflow developed at the University of Florida to deliver LITT in conscious patients without the use of general anesthesia. OBJECTIVE: To describe a novel workflow for LITT implementation in the awake patient with equivalent treatment results when compared to procedures performed under general anesthesia...
February 10, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29439885/early-tissue-effects-of-stereotactic-body-radiation-therapy-for-spinal-metastases
#9
Jasper G Steverink, Stefan M Willems, Marielle E P Philippens, Nicolien Kasperts, Wietse S C Eppinga, Anne L Versteeg, Joanne M van der Velden, Salman Faruqi, Arjun Sahgal, Jorrit-Jan Verlaan
PURPOSE: Stereotactic body radiation therapy (SBRT) is a highly effective and potentially ablative treatment for complex spinal metastases. Recent data have suggested radiobiologic effects of SBRT that expand beyond the traditional concept of DNA damage. Antitumor immunity, vascular damage leading to tumor necrosis, and increased rates of tumor apoptosis have been implied; however, in-human evidence remains scarce. The present study reports unique pathologic confirmation of SBRT-induced biological effects within spinal metastases treated with preoperative SBRT...
January 6, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29431850/improvement-of-off-axis-sabr-plan-verification-results-by-using-adapted-dose-reconstruction-algorithms-for-the-octavius4d-system
#10
Prakash Jeevanandam, Christina E Agnew, Denise M Irvine, Conor K McGarry
PURPOSE: Stereotactic ablative body radiotherapy (SABR) for lung patients can be performed with VMAT plans using off-axis target geometry to allow treatment in their CBCT verified position. For patient specific quality assurance measurements using the PTW Octavius 4D phantom (PTW, Freiburg, Germany) (OCT4D) in conjunction with an Octavius 1000SRS array (OCT1000) (PTW, Freiburg, Germany), repositioning the phantom off-axis is required to ensure the measurement area coincides with the tumor...
February 12, 2018: Medical Physics
https://www.readbyqxmd.com/read/29427352/a-rare-case-of-epstein-barr-virus-associated-hepatosplenic-smooth-muscle-tumors-after-kidney-transplantation
#11
Christoph Pircher, Stefan Schneeberger, Claudia Boesmueller, Abbas Agaimy, Heinz Zoller, Reto Bale, Benjamin Henninger, Gert Mayer, Hannes Neuwirt
A 27-year old caucasian male was diagnosed 2.7 years after kidney transplantation with Epstein-Barr virus (EBV)-associated smooth muscle tumors in liver and spleen. The reduction of immunosuppression and conversion from tacrolimus to sirolimus did not lead to a regression of the tumors. Additionally, the patient developed a cellular rejection of his renal allograft, which was successfully treated. A combined approach with stereotactic radiofrequency ablation (SRFA) and surgical resection was effective in the treatment of the tumors...
February 10, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29425986/is-edema-a-matter-of-concern-after-laser-ablation-of-epileptogenic-focus
#12
Vivek Tandon, Michael Lang, Poodipedi Sarat Chandra, Ashwini Sharan, Ajay Garg, Manjari Tripathi
BACKGROUND: A stereotactically placed laser fiber can deliver thermal energy to an epileptogenic focus in brain. This procedure is done under intraoperative (thermography) magnetic resonance imaging (MRI) guidance. Thermoablation can lead to edema in surrounding area and can cause secondary insult. In this case report of three cases, we have quantified the edema produced after laser ablation, with sequential MRI in immediate post-operative period. CASE DESCRIPTION(S): Three patients of intractable epilepsy underwent proper neurological and neuro-radiological workup to localize the site of epileptogenic foci...
February 6, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29423821/the-emerging-role-of-stereotactic-radiotherapy-in-gastrointestinal-malignancies-a-review-of-the-literature-and-analysis-from-the-irish-perspective
#13
Siobhra O'Sullivan, Daniel N Cagney
Primary and secondary malignancies of the liver and pancreas result in significant morbidity and mortality, with increasing incidence and increasing demands on health services worldwide. Surgery is the only curative single modality of treatment and remains the gold standard. Unfortunately, up to 80% of the patients present with unresectable disease, and so, alternative efficacious local and systemic treatments are needed. Technologic advances in radiotherapy over recent decades have meant that precision high-dose treatment with stereotactic body radiotherapy (SBRT) has emerged as a viable cost-effective outpatient-based treatment in the management of these difficult to treat abdominal malignancies...
February 8, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29423737/aggressive-and-multidisciplinary-local-approach-to-iterative-recurrences-of-colorectal-liver-metastases
#14
Luca Viganò, Vittorio Pedicini, Tiziana Comito, Carlo Carnaghi, Guido Costa, Dario Poretti, Ciro Franzese, Nicola Personeni, Daniele Del Fabbro, Lorenza Rimassa, Marta Scorsetti, Armando Santoro, Luigi Solbiati, Guido Torzilli
BACKGROUND: Liver resection (LR) of colorectal metastases is associated with high recurrence risk. Aggressive local retreatment is advocated, but further recurrences may occur. Poor is known about presentation, treatment, and outcome of iterative recurrences. METHODS: A series of 323 consecutive patients undergoing first LR in the period 2004-2013 was reviewed. Patients with recurrence were included. Any local treatment (surgery, radiofrequency ablation (RFA) and stereotactic body radiation therapy (SBRT)) was analyzed...
February 8, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29420840/stereotactic-laser-amygdalohippocampotomy-for-mesial-temporal-lobe-epilepsy
#15
Robert E Gross, Matthew A Stern, Jon T Willie, Rebecca E Fasano, Amit M Saindane, Bruno P Soares, Nigel P Pedersen, Daniel L Drane
OBJECTIVE: To evaluate the outcomes one-year and longer following stereotactic laser amygdalohippocampotomy for mesial temporal lobe epilepsy in a large series of patients treated over a five-year period since introduction of this novel technique. METHODS: Surgical outcomes of a consecutive series of fifty-eight patients with mesial temporal lobe epilepsy who underwent the surgery at our institution with at least 12-months follow-up were retrospectively evaluated...
February 8, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29416719/response-to-stereotactic-ablative-radiotherapy-in-a-novel-orthotopic-model-of-non-small-cell-lung-cancer
#16
Ayman Oweida, Siham Sabri, Areej Al-Rabea, Mojgan Ebrahimi, Russel Ruo, Richard Fraser, Jan Seuntjens, Bassam Abdulkarim
Stereotactic ablative radiotherapy (SABR) is the main treatment for inoperable early-stage non-small cell lung cancer (NSCLC). Despite the widespread use of SABR, the biological determinants of response to SABR remain poorly investigated. We developed an orthotopic NSCLC animal model to study the response to clinically-relevant doses of SABR. Image-guided intra-thoracic injection of NSCLC cells was performed in the right lung of nude rats. A highly conformal dose of 34 Gy was delivered in a single fraction using clinical photon energies...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29414561/a-modern-epilepsy-surgery-treatment-algorithm-incorporating-traditional-and-emerging-technologies
#17
REVIEW
Dario J Englot
Epilepsy surgery has seen numerous technological advances in both diagnostic and therapeutic procedures in recent years. This has increased the number of patients who may be candidates for intervention and potential improvement in quality of life. However, the expansion of the field also necessitates a broader understanding of how to incorporate both traditional and emerging technologies into the care provided at comprehensive epilepsy centers. This review summarizes both old and new surgical procedures in epilepsy using an example algorithm...
February 1, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29413285/normal-tissue-complication-probability-modeling-of-pulmonary-toxicity-after-stereotactic-and-hypofractionated-radiation-therapy-for-central-lung-tumors
#18
H Tekatli, M Duijm, E Oomen-de Hoop, W Verbakel, W Schillemans, B J Slotman, J J Nuyttens, S Senan
PURPOSE: To evaluate clinical pulmonary and radiographic bronchial toxicity after stereotactic ablative radiation therapy and hypofractionated radiation therapy for central lung tumors, and perform normal tissue complication probability modeling and multivariable analyses to identify predictors for toxicity. METHODS AND MATERIALS: A pooled analysis was performed of patients with a central lung tumor treated using ≤12 fractions at 2 centers between 2006 and 2015...
March 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29408592/stereotactic-radiofrequency-thermocoagulation-of-hypothalamic-hamartoma-using-robotic-guidance-rosa-co-registered-with-o-arm-guidance-preliminary-technical-note
#19
Vivek Tandon, Poodipedi Sarat Chandra, Ramesh Sharanappa Doddamani, Heri Subianto, Jitin Bajaj, Ajay Garg, Manjari Tripathi
INTRODUCTION: Treatment options for hypothalamic hamartoma (HH) include microvascular surgery, stereotactic radiofrequency thermocoagulation (SRT), laser interstitial thermal therapy (LITT) or Gamma knife surgery (GKS). During SRT, thermographic monitoring cannot be performed and therefore highly accurate placement of electrode and confirmation of its position are required. We have utilized robotic guidance (ROSA) and co-registered it with O-Arm, for performing ablation of hamartoma. METHODS: Five patients of HH with gelastic seizures (GS) underwent SRT...
February 3, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29395853/bronchiolitis-obliterans-organizing-pneumonia-after-stereotactic-ablative-radiation-therapy-for-lung-cancer-a-case-report
#20
G Fanetti, F Bazzani, A Ferrari, D Alterio, S M Donghi, F A Pounou Kamga, R Orecchia, B A Jereczek-Fossa
Bronchiolitis obliterans organizing pneumonia is an interstitial lung disease rarely occurring after radiotherapy probably due to an activation of autoimmune processes. Most cases have been described after postoperative radiotherapy for breast cancer. Corticosteroids represent the main treatment, prognosis is generally favorable. We described a case of bronchiolitis obliterans organizing pneumonia after stereotactic ablative radiation therapy for a recurrent lung cancer. Antibiotics and steroids were administered to solve the clinical picture...
January 26, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
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