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Stereotactic ablative

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https://www.readbyqxmd.com/read/28222111/a-meta-analysis-of-the-abscopal-effect-in-preclinical-models-is-the-biologically-effective-dose-a-relevant-physical-trigger
#1
Raffaella Marconi, Silvia Strolin, Gianluca Bossi, Lidia Strigari
BACKGROUND: Preclinical in vivo studies using small animals are considered crucial in translational cancer research and clinical implementation of novel treatments. This is of paramount relevance in radiobiology, especially for any technological developments permitted to deliver high doses in single or oligo-fractionated regimens, such as stereotactic ablative radiotherapy (SABR). In this context, clinical success in cancer treatment needs to be guaranteed, sparing normal tissue and preventing the potential spread of disease or local recurrence...
2017: PloS One
https://www.readbyqxmd.com/read/28218383/stereotactic-ablative-radiation-therapy-as-a-potential-curative-treatment-in-duodenal-adenocarcinoma-a-case-report
#2
Francesco Maria Aquilanti, Maria Cristina Barba, Federico Bianciardi, Barbara Tolu, Barbara Nardiello, Giorgio Hamid Raza, Randa El Gawhary, Chiara D'Ambrosio, PierCarlo Gentile
PURPOSE: One of the rarest gastrointestinal neoplasm is small bowel cancer. Experience with its treatment modalities is limited. Stereotactic ablative radiation therapy (SABR) has improved, with image-guided radiation therapy becoming a curative option in many tumors. Especially when surgery cannot be performed due to comorbidities, SABR provides a good toxicity profile and an excellent tumor control rate owing to its specific schedule: high dose on a limited and well-defined area. METHODS: An 83-year-old man had arterial hypertension and congestive cardiomyopathy, with recent history of upper abdominal pain, weight loss over 10 kg, and progressive severe fatigue...
February 11, 2017: Tumori
https://www.readbyqxmd.com/read/28215455/lung-ablation-best-practice-results-response-assessment-role-alongside-other-ablative-therapies
#3
REVIEW
T de Baere, L Tselikas, G Gravel, F Deschamps
Today, in addition to surgery, other local therapies are available for patients with small-size non-small-cell lung cancer (NSCLC) and oligometastatic disease from various cancers. Local therapies include stereotactic ablation radiotherapy (SABR) and thermal ablative therapies through percutaneously inserted applicators. Although radiofrequency ablation (RFA) has been explored in series with several hundreds of patients with pulmonary tumours, investigation of the potential of other ablation technologies including microwave ablation, cryoablation, and irreversible electroporation is ongoing...
February 16, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28209456/the-role-of-stereotactic-ablative-body-radiotherapy-in-gynaecological-cancers-a-systematic-review
#4
L C Mendez, E Leung, P Cheung, L Barbera
AIMS: To summarise and evaluate the current literature in gynaecological tumours treated with stereotactic ablative body radiotherapy (SABR) through a systematic review using the Preferred Reported Items for Systematic Reviews and Meta-analysis (PRISMA) guideline. MATERIALS AND METHODS: A literature search through Medline, EMBASE and Cochrane databases resulted in 22 pertinent manuscripts. Selected studies evaluated the locoregional role of SABR in gynaecological tumours, regardless of SABR clinical indication...
February 13, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28188682/stereotactic-ablative-body-radiotherapy-for-inoperable-primary-kidney-cancer-a-prospective-clinical-trial
#5
Shankar Siva, Daniel Pham, Tomas Kron, Mathias Bressel, Jacqueline Lam, Tan Teng Han, Brent Chesson, Mark Shaw, Sarat Chander, Suki Gill, Nicholas R Brook, Nathan Lawrentschuck, Declan G Murphy, Farshad Foroudi
OBJECTIVE: To assess the feasibility and safety of stereotactic ablative body radiotherapy (SABR) for RCC in patients unsuitable for surgery. Secondary objectives were to assess oncologic and functional outcomes. MATERIALS AND METHODS: This was a prospective interventional clinical trial with institutional ethics board approval. Inoperable patients were enrolled after multidisciplinary consensus for intervention and informed consent. Tumor response was defined using RECIST 1...
February 10, 2017: BJU International
https://www.readbyqxmd.com/read/28167089/alternative-approaches-for-ablation-of-resistant-ventricular-tachycardia
#6
REVIEW
Carola Gianni, Sanghamitra Mohanty, Chintan Trivedi, Luigi Di Biase, Amin Al-Ahmad, Andrea Natale, J David Burkhardt
Ventricular tachycardia (VT) ablation is usually performed with an ablation catheter that delivers unipolar radiofrequency (RF) energy to eliminate the re-entry circuit responsible for VT. However, there are some instances when unipolar RF ablation fails, notably in VTs with a deep intramural origin, or cases in which epicardial access is not attainable due to prior cardiac surgery. To overcome these limitations, several alternative approaches have been used in clinical practice, including alcohol ablation or coil embolization, simultaneous unipolar or bipolar RF ablation, surgical ablation, or noninvasive ablation with stereotactic radiosurgery...
March 2017: Cardiac Electrophysiology Clinics
https://www.readbyqxmd.com/read/28159908/regulation-of-synaptic-a%C3%AE-generation-through-bace1-retrograde-transport-in-a-mouse-model-of-alzheimer-s-disease
#7
Xuan Ye, Tuancheng Feng, Prasad Tammineni, Qing Chang, Yu Young Jeong, David J Margolis, Huaibin Cai, Alexander Kusnecov, Qian Cai
: β-amyloid (Aβ) peptides play a key role in synaptic damage and memory deficits in the early pathogenesis of Alzheimer's disease (AD). Abnormal accumulation of Aβ at nerve terminals leads to synaptic pathology and ultimately to neurodegeneration. β-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) is the major neuronal β-secretase for Aβ generation. However, the mechanisms regulating BACE1 distribution in axons and β cleavage of APP at synapses remain largely unknown...
February 3, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28151535/pros-after-stereotactic-ablative-radiotherapy-for-a-peripheral-early-stage-non-small-cell-lung-cancer-radiological-suspicion-of-a-local-recurrence-can-be-sufficient-indication-to-proceed-to-salvage-therapy
#8
EDITORIAL
https://www.readbyqxmd.com/read/28143558/lung-metastases-treated-with-stereotactic-body-radiotherapy-the-rssearch%C3%A2-patient-registry-s-experience
#9
Anthony Ricco, Joanne Davis, William Rate, Jun Yang, David Perry, John Pablo, David D'Ambrosio, Sanjeev Sharma, Srinath Sundararaman, James Kolker, Kimberly M Creach, Rachelle Lanciano
OBJECTIVES: To report overall survival and local control for patients identified in the RSSearch® Patient Registry with metastatic cancer to the lung treated with SBRT. METHODS: Seven hundred two patients were identified with lung metastases in the RSSearch® Registry. Of these patients, 577 patients had SBRT dose and fractionation information available. Patients were excluded if they received prior surgery, radiation, or radiofrequency ablation to the SBRT treated area...
February 1, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28133340/-long-term-local-control-with-radiofrequency-ablation-or-radiotherapy-for-second-third-and-fourth-lung-tumors-after-lobectomy-for-primary-lung-cancer
#10
Hideoki Yokouchi, Masaki Miyazaki, Takeaki Miyamoto, Takafumi Minami, Fumio Tsuji, Koji Mikami, Kohei Murata
A 78-year-old woman developed second, third, and fourth lung tumors at intervals of 1-3 years after left upper lobectomy for primary lung cancer. The tumors were controlled with radiofrequency ablation(RFA)or conventionalconformalradiotherapy for 9 years postoperatively. For the treatment of second primary lung cancer or lung metastasis after surgical resection of the primary lung cancer, reoperation is not recommended because of the impaired respiratory reserve. Thus, local therapy such as radiotherapy or RFA is applied in some cases...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28129789/short-report-interim-safety-results-for-a-phase-ii-trial-measuring-the-integration-of-stereotactic-ablative-radiotherapy-sabr-plus-surgery-for-early-stage-non-small-cell-lung-cancer-missile-nsclc
#11
David A Palma, Timothy K Nguyen, Keith Kwan, Stewart Gaede, Mark Landis, Richard Malthaner, Dalilah Fortin, Alexander V Louie, Eric Frechette, George B Rodrigues, Brian Yaremko, Edward Yu, A Rashid Dar, Ting-Yim Lee, Al Gratton, Andrew Warner, Aaron Ward, Richard Inculet
: A phase II trial was launched to evaluate if neoadjuvant stereotactic ablative radiotherapy (SABR) before surgery improves oncologic outcomes in patients with stage I non-small cell lung cancer (NSCLC). We report a mandated interim safety analysis for the first 10 patients who completed protocol treatment. Operable patients with biopsy-proven T1-2 N0 NSCLC were eligible. SABR was delivered using a risk-adapted fractionation (54Gy/3 fractions, 55/5 or 60/8). Surgical resection was planned 10 weeks later at a high-volume center (>200 lung cancer resections annually)...
January 27, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28126325/stereotactic-ablative-radiation-therapy-for-lung-oligometastases-predictive-parameters-of-early-response-by-18-fdg-pet-ct
#12
Rosario Mazzola, Alba Fiorentino, Gioacchino Di Paola, Niccolò Giaj Levra, Francesco Ricchetti, Sergio Fersino, Umberto Tebano, Stefano Pasetto, Ruggero Ruggieri, Matteo Salgarello, Filippo Alongi
OBJECTIVES: The objective of this study was to investigate fludeoxyglucose F 18 positron emission tomography/computed tomography ((18)FDG-PET/CT) parameters as predictive of response after stereotactic ablative radiotherapy (SABR) for lung oligometastases. METHODS: The inclusion criteria of the current retrospective study were as follows: (1) lung oligometastases treated by SABR, (2) presence of (18)FDG-PET/CT before and after SABR for at least two subsequent evaluations, (3) Karnofsky performance status higher than 80, and (4) life expectancy longer than 6 months...
March 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28123916/stereotactic-body-radiotherapy-for-inoperable-liver-tumors-results-of-a-single-institutional-experience
#13
Hussam Hijazi, Marie-Pierre Campeau, David Roberge, David Donath, Real Lapointe, Franck Vandenbroucke-Menu, Daniel Taussky, Karim Boudam, Gabriel Chan, Alexis Bujold, Guila Delouya
OBJECTIVES: Stereotactic body radiation therapy (SBRT) is an emerging treatment option for liver tumors unsuitable for ablation or surgery. We report our experience with SBRT in the treatment of liver tumors. MATERIALS AND METHODS: Patients with primary or secondary liver cancer were identified in our local SBRT database. Patients were included irrespective of prior liver-directed therapies. The primary endpoint of our review was in-field local control (LC). Secondary endpoints were progression-free survival (PFS), overall survival (OS), and toxicity...
December 20, 2016: Curēus
https://www.readbyqxmd.com/read/28122893/clinical-outcomes-of-stereotactic-ablative-radiotherapy-in-patients-with-pulmonary-metastasis
#14
Bum-Sup Jang, Hak Jae Kim, Byoung Hyuck Kim, Dong-Wan Kim, Young Tae Kim, Young Whan Kim, Myoung-Jin Jang, Hong-Gyun Wu
BACKGROUNDS: In addition to its curative use for early stage lung cancer, stereotactic ablative radiotherapy is also indicated for pulmonary metastatic disease. Aims of this study were to retrospectively analyze treatment outcomes and to find prognostic factors for survivals. METHODS: Treatment outcomes and toxicities of 85 cases of SABR in 72 patients were retrospectively reviewed from September 2012 to April 2015. Prognostic factors were analyzed using Cox proportional hazards regression...
January 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28117079/a-national-dosimetry-audit-for-stereotactic-ablative-radiotherapy-in-lung
#15
Gail Distefano, Jonny Lee, Shakardokht Jafari, Clare Gouldstone, Colin Baker, Helen Mayles, Catharine H Clark
BACKGROUND AND PURPOSE: A UK national dosimetry audit was carried out to assess the accuracy of Stereotactic Ablative Body Radiotherapy (SABR) lung treatment delivery. METHODS AND MATERIALS: This mail-based audit used an anthropomorphic thorax phantom containing nine alanine pellets positioned in the lung region for dosimetry, as well as EBT3 film in the axial plane for isodose comparison. Centres used their local planning protocol/technique, creating 27 SABR plans...
January 20, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28116853/utility-of-68-ga-prostate-specific-membrane-antigen-positron-emission-tomography-in-diagnosis-and-response-assessment-of-recurrent-renal-cell-carcinoma
#16
Shankar Siva, Jason Callahan, David Pryor, Jarad Martin, Nathan Lawrentschuk, Michael S Hofman
INTRODUCTION: Prostate specific membrane antigen (PSMA) positron emission tomography (PET) is an emerging imaging modality in prostate cancer. However, (68) Ga-PSMA-PET may also have diagnostic utility in the setting of renal cell carcinoma (RCC). We investigate the differential role of (18) F-fluorodeoxyglucose (FDG) and PSMA-PET/CT scanning in patients with oligometastatic RCC. In particular, we focus on the utility of PSMA-PET for diagnostic evaluation of isolated or limited metastases planned for local surgery or radiation, as well as the potential utility of PSMA-PET for therapeutic response assessment in patients receiving stereotactic ablative body radiotherapy (SABR)...
January 24, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28096104/recent-developments-in-the-surgical-management-of-paediatric-epilepsy
#17
REVIEW
Vijay M Ravindra, Matthew T Sweney, Robert J Bollo
Among the 1% of children affected by epilepsy, failure of pharmacological therapy and early age of seizure onset can lead to worse long-term cognitive outcomes, mental health disorders and impaired functional status. Surgical management often improves functional and cognitive outcomes in children with medically refractory epilepsy, especially when seizure remission is achieved. However, surgery remains underused in children with drug-resistant epilepsy, creating a large treatment gap. Several recent innovations have led to considerable improvement in surgical technique, including the recent development of minimally invasive diagnostic and therapeutic techniques such as stereotactic EEG, transcranial magnetic stimulation, MRI-guided laser ablation, as well as novel paradigms of neurostimulation...
January 17, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28078405/-radiosurgery-and-fractionated-stereotactic-radiotherapy-of-vestibular-schwannoma
#18
K Hamm, H-U Herold, G Surber, S Rosahl
Management of vestibular schwannoma (VS) should always be interdisciplinary and results better than the natural course. Particularly in small VS, either microsurgical resection or radiosurgery (RS) can be employed. RS is a special method (initially only possible stereotactically) for delivering high-precision radiation from many directions to the target point (the isocenter) in a single high dose. With the development of three different systems-Gamma Knife (Elekta, Stockholm, Sweden), special linear accelerators, and CyberKnife (Accuray, Sunnyvale, CA, USA)-the options were extended to 1-5 fractions for RS and multisession RS (msRS), and to up to 6 weeks of conventional fractionation as stereotactic radiotherapy (SRT)...
January 11, 2017: HNO
https://www.readbyqxmd.com/read/28074327/when-should-negative-endobronchial-ultrasonography-findings-be-confirmed-by-a-more-invasive-procedure
#19
Basil S Nasir, Kazuhiro Yasufuku, Moishe Liberman
The treatment of non-small cell lung cancer is largely dependent on accurate staging in order to determine appropriate therapy. Despite advances in imaging, such as computed tomography and positron emission tomography, invasive mediastinal staging is frequently needed to rule out mediastinal involvement prior to curative-intent stereotactic ablative radiotherapy or surgical resection. Surgical mediastinal staging with mediastinoscopy, or anterior mediastinotomy, were traditionally considered the gold standard for invasive mediastinal staging...
January 10, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28058710/stereotactic-ablative-radiotherapy-for-patients-with-unresectable-or-medically-inoperable-cholangiocarcinoma
#20
Ming-Yueh Liu, Cheng-Hsiang Lo, Chun-Shu Lin, Hsing-Lung Chao, Jen-Fu Yang, Kuen-Tze Lin, Chao-Yueh Fan, Yu-Fu Su, Wen-Yen Huang
PURPOSE: The role of stereotactic ablative radiotherapy (SABR) in patients with unresectable or medically inoperable cholangiocarcinoma remains unclear. We examined the efficacy and safety of SABR in this group of patients. METHODS: From January 2008 to December 2014, 15 patients with 17 lesions were included in this study. The lesions included 14 intrahepatic, 1 hilar, and 2 distal bile duct tumors. Three patients were classified as medically inoperable because of old age or multiple comorbidities...
January 5, 2017: Tumori
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