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Stereotactic ablative

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https://www.readbyqxmd.com/read/29678783/safety-and-efficacy-of-stereotactic-radioablation-targeting-pulmonary-vein-tissues-in-an-experimental-model
#1
Paul C Zei, Doug Wong, Edward Gardner, Thomas Fogarty, Patrick Maguire
BACKGROUND: Stereotactic radioablation (SR), a commonly used therapy to treat malignancies, has been utilized to treat refractory ventricular tachycardia, but the feasibility of treating atrial fibrillation (AF) with SR is unknown. OBJECTIVE: We evaluated the safety and efficacy of SR targeting pulmonary vein (PV) antral tissues as potential therapy for AF. METHODS: Seventeen adult canines and two adult swine underwent surgical fiducial marker placement, 3D anatomic rendering CT angiogram of the left atrium (LA), and creation of a treatment plan targeting the right superior pulmonary veins (RSPVs)...
April 17, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29678159/stereotactic-body-radiation-therapy-as-an-effective-and-safe-treatment-for-small-hepatocellular-carcinoma
#2
Tao Zhang, Jing Sun, Weiping He, Huan Li, Junjie Piao, Huijun Xu, Xuezhang Duan
BACKGROUND: To evaluate the efficacy and safety of stereotactic body radiation therapy (SBRT) in patients with small hepatocellular carcinoma(sHCC) who were ineligible for surgery or ablation therapies. METHODS: From March 2011 to December 2012, 28 cases with sHCC which were ineligible or refused surgical resection, transplantation or local ablation were treated with CyberKnife SBRT. Median size of tumors was 2.1 cm (range:1.1-3.0 cm), a dose of 10-15Gy per faction was given over 3-6 consecutive days, resulting in a total dose of 35-60Gy...
April 20, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29672204/thoracic-intervention-and-surgery-to-cure-lung-an-overview-of-stereotactic-ablative-radiotherapy-in-early-and-oligometastatic-lung-cancer
#3
Bsh Chia, D Landau, G Hanna, J Conibear
No abstract text is available yet for this article.
January 1, 2018: Journal of the Royal Society of Medicine
https://www.readbyqxmd.com/read/29666135/study-protocol-for-the-saron-trial-a-multicentre-randomised-controlled-phase-iii-trial-comparing-the-addition-of-stereotactic-ablative-radiotherapy-and-radical-radiotherapy-with-standard-chemotherapy-alone-for-oligometastatic-non-small-cell-lung-cancer
#4
John Conibear, Brendan Chia, Yenting Ngai, Andrew Tom Bates, Nicholas Counsell, Rushil Patel, David Eaton, Corinne Faivre-Finn, John Fenwick, Martin Forster, Gerard G Hanna, Susan Harden, Philip Mayles, Syed Moinuddin, David Landau
INTRODUCTION: Following growing evidence to support the safety, local control (LC) and potential improvement in overall survival (OS) in patients with oligometastatic non-small cell lung cancer (NSCLC) that have been treated with local ablative therapy such as stereotactic ablative radiotherapy (SABR) and stereotactic radiosurgery (SRS), we initiate the SARON trial to investigate the impact and feasibility of adding SABR/SRS and radical radiotherapy (RRT) following standard chemotherapy on OS...
April 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29650404/stereotactic-ablative-radiotherapy-after-concomitant-chemoradiotherapy-in-non-small-cell-lung-cancer-a-tite-crm-phase-1-trial
#5
Jérôme Doyen, Michel Poudenx, Jocelyn Gal, Josiane Otto, Caroline Guerder, Arash O Naghavi, Anais Gérard, Axel Leysalle, Charlotte Cohen, Bernard Padovani, Antoine Ianessi, Renaud Schiappa, Emmanuel Chamorey, Pierre-Yves Bondiau
BACKGROUND AND PURPOSE: Platinum based chemoradiotherapy is the standard of care for inoperable non-small cell lung cancer (NSCLC). With evidence that NSCLC can have a dose dependent response with stereotactic ablative radiotherapy (SABR), we hypothesize that a SABR boost on residual tumor treated with chemoradiotherapy could increase treatment efficacy. The purpose of this study was to determine feasibility of such an approach. MATERIAL AND METHODS: A prospective phase I trial was performed including 26 patients...
April 9, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29627122/radiofrequency-thermoablation-general-principle-historical-overview-and-modern-applications-for-epilepsy
#6
J Voges, L Büntjen, F C Schmitt
Stereotactically guided radiofrequency thermoablation (RFTA) for epilepsy has been frequently applied over the last 40 years. Radiofrequency electrodes with temperature control function generate a coagulation lesion with clearly defined borders. In combination with high-resolution MRI imaging, this technique allows minimally-invasive ablation of periventricular nodular heterotopias, small focal type II dysplasias, and hypothalamic hamartomas. This review summarises the literature addressing this topic mainly regarding technical aspects...
March 28, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29619976/ablative-hypofractionated-radiation-therapy-enhances-non-small-cell-lung-cancer-cell-killing-via-preferential-stimulation-of-necroptosis-in-vitro-and-in-vivo
#7
Huan-Huan Wang, Zhi-Qiang Wu, Dong Qian, Nicholas G Zaorsky, Ming-Han Qiu, Jing-Jing Cheng, Chao Jiang, Juan Wang, Xian-Liang Zeng, Chun-Lei Liu, Li-Jun Tian, Guo-Guang Ying, Mao-Bin Meng, Xi-Shan Hao, Zhi-Yong Yuan
PURPOSE: To investigate how necroptosis (ie, programmed necrosis) is involved in killing of non-small cell lung cancer (NSCLC) after ablative hypofractionated radiation therapy (HFRT). METHODS AND MATERIALS: Deoxyribonucleic acid damage, DNA repair, and the death form of NSCLC cells were assessed after radiation therapy. The overexpression and silencing of receptor-interacting protein kinases 3 (RIP3, a key protein involved activation of necroptosis)-stable NSCLC cell lines were successfully constructed...
May 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29619964/stereotactic-ablative-radiation-therapy-versus-surgery-in-early-lung-cancer-a-meta-analysis-of-propensity-score-studies
#8
Hanbo Chen, Joanna M Laba, R Gabriel Boldt, Christopher D Goodman, David A Palma, Suresh Senan, Alexander V Louie
PURPOSE: As no completed randomized trials of surgery versus stereotactic ablative radiation therapy (SABR) in patients with early-stage non-small cell lung cancer are available, numerous propensity score studies have attempted to mimic the setting of clinical trials using nonrandomized data. We performed a meta-analysis of propensity score studies comparing SABR and surgery. METHODS AND MATERIALS: The MEDLINE and Embase databases were queried up to December 2016...
May 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29614361/effectiveness-of-pet-ct-as-a-guide-for-palliative-radiation-therapy-for-spinal-metastases
#9
Neil D Almeida, Crystal Adams, Gregory L Davis, Justin Buro, Nadim Nasr, Don McRae, George Cernica, Anthony Caputy, Robert Hong, Jonathan Sherman
BACKGROUND: As back pain is the presenting symptoms in 95% of patients with epidural spinal metastases, appropriately identifying and treating the most symptomatic levels can provide significant palliation. OBJECTIVE: The purpose of this study is to analyze the ability of PET-CT to identify spinal metastases with high metabolic activity and guide radiotherapy. We sought to correlate improvement in back pain with reduction in SUV uptake following treatment. METHODS: We conducted a retrospective review of 72 patients with bony spinal metastases treated with stereotactic ablative radiation therapy at a single center between 2002 and 2014...
March 31, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29608606/lung-density-change-after-sabr-a-comparative-study-between-tri-co-60-magnetic-resonance-guided-system-and-linear-accelerator
#10
Eunji Kim, Hong-Gyun Wu, Jong Min Park, Jung-In Kim, Hak Jae Kim, Hyun-Cheol Kang
Radiation-induced lung damage is an important treatment-related toxicity after lung stereotactic ablative radiotherapy (SABR). After implementing a tri-60Co magnetic-resonance image guided system, ViewRayTM, we compared the associated early radiological lung density changes to those associated with a linear accelerator (LINAC). Eight patients treated with the tri-60Co system were matched 1:1 with patients treated with LINAC. Prescription doses were 52 Gy or 60 Gy in four fractions, and lung dose-volumetric parameters were calculated from each planning system...
2018: PloS One
https://www.readbyqxmd.com/read/29607130/utility-of-stereotactic-ablative-radiotherapy-stereotactic-body-radiation-therapy-in-the-setting-of-oligometastatic-non-small-cell-lung-cancer
#11
EDITORIAL
Andrew Song, Bo Lu
No abstract text is available yet for this article.
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29606150/stereotactic-ablative-radiotherapy-for-ultra-central-lung-tumors-prioritize-target-coverage-or-organs-at-risk
#12
Donna H Murrell, Joanna M Laba, Abigail Erickson, Barbara Millman, David A Palma, Alexander V Louie
BACKGROUND: Lung stereotactic ablative radiotherapy (SABR) is associated with low morbidity, however there is an increased risk of treatment-related toxicity in tumors directly abutting or invading the proximal bronchial tree, termed 'ultra-central' tumors. As there is no consensus regarding the optimal radiotherapy treatment regimen for these tumors, we performed a modeling study to evaluate the trade-offs between predicted toxicity and local control for commonly used high-precision dose-fractionation regimens...
April 2, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29600013/stereotactic-ablative-radiotherapy-for-oligometastatic-non-small-cell-lung-cancer
#13
EDITORIAL
Vivek Verma, Joe Y Chang
No abstract text is available yet for this article.
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29594874/oligometastatic-cancer-in-elderly-patients-the-blitzkrieg-radiotherapy-approach-sbrt-in-oligometastatic-elderly-patients
#14
Andrea Lancia, Gianluca Ingrosso, Alessandra Carosi, Marta Bottero, Alessandro Cancelli, Irene Turturici, Elisabetta Ponti, Riccardo Santoni
AIMS: To retrospectively evaluate the outcome of stereotactic body radiation therapy (SBRT) in the treatment of elderly patients affected by isolated body metastasis from different primitive tumors. METHODS: 70 patients with isolated body metastasis were treated. Median age at diagnosis was 75 years (IQR 69-80). The most common SBRT fractionation scheme was 5 × 7 Gy (total dose 35 Gy). The primary endpoints were Local Control (LC) and Toxicity. Secondary endpoints were Overall Survival (OS) and Disease-Specific Survival (DSS)...
March 29, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29594220/role-of-radiotherapy-in-extracranial-metastatic-malignant-melanoma-in-the-modern-era
#15
Ryan S Youland, Miran L Blanchard, Roxanna Dronca, Lisa Kottschade, Svetomir N Markovic, Kenneth R Olivier, Sean S Park
Background: To assess the role of radiotherapy in metastatic malignant melanoma (MM) patients in modern era. Materials and methods: This is a retrospective study of MM patients treated with radiotherapy at Mayo Clinic from 1999 to 2014. Patients with pre- and post-treatment imaging studies (CT, MRI, and/or PET/CT) were assessed for metastasis failure (MF), regional/distant failure, and overall survival (OS). Results: In 75 MM patients, 56 and 68 lesions were treated with conventional/hypofractionated radiotherapy (CHRT) and stereotactic body radiotherapy (SBRT), respectively...
October 2017: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29594215/age-not-charlson-co-morbidity-index-predicts-for-mortality-after-stereotactic-ablative-radiotherapy-for-medically-inoperable-stage-i-non-small-cell-lung-cancer
#16
Oliver Edwin Holmes, Robert MacRae, Graham Cook, Peter Cross, Vimoj Nair, Horia Marginean, Jason R Pantarotto
Purpose: In this single institution retrospective study of patients with stage I medically inoperable non-small cell lung cancer (NSCLC) treated with stereotactic ablative radiotherapy (SABR) we attempt to model overall survival (OS) using initial prognostic variables with specific attention on the Charlson co-morbidity index (CCI). Methods: Between 2008 and 2013, 335 patients with medically inoperable stage I NSCLC were treated with SABR or hypofractionated radiotherapy (50-60 Gy in at least 5 Gy or 4 Gy fractions respectively) at our institution...
August 2017: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29588072/dose-escalation-for-prostate-stereotactic-ablative-radiotherapy-sabr-late-outcomes-from-two-prospective-clinical-trials
#17
Yasir Alayed, Patrick Cheung, Geordi Pang, Alexandre Mamedov, Laura D'Alimonte, Andrea Deabreu, Kristina Commisso, Angela Commisso, Liang Zhang, Harvey C Quon, Hima Bindu Musunuru, Joelle Helou, D Andrew Loblaw
PURPOSE: Optimal prostate SABR dose-fractionation is unknown. This study compares long-term outcomes from two prospective trials. METHODS: Study1 patients had low-risk PCa and received 35 Gy/5. Study2 patients had low/intermediate-risk PCa and received 40 Gy/5. Biochemical failure (BF) was defined as nadir + 2. RESULTS: 114 patients were included (study1, n = 84; study2, n = 30). Median follow-up was 9.6 years and 6.9 years...
March 24, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29578359/approach-to-oligometastatic-disease-in-head-and-neck-cancer-on-behalf-of-the-gortec
#18
Xu Shan Sun, Cécile Michel, Emmanuel Babin, Dominique De Raucourt, Adeline Péchery, Elisabeta Gherga, Bernard Géry, Carmen Florescu, Jean Bourhis, Juliette Thariat
Median survival for recurrent/metastatic head and neck squamous cell cancer (HNSCC) patients is about 10 months after first-line best systemic treatment. We aimed to assess current approaches of oligometastatic HNSCC patients by the analysis of current concept and published data (1995-2017) in this population. Five-year survival rates are over 20% in selected patients who undergo metastasis-directed therapy by either surgery or stereotactic irradiation. Human papillomavirus(+) HNSCC patients have more disseminated metastases but respond more favorably and also benefit from ablative treatments...
March 26, 2018: Future Oncology
https://www.readbyqxmd.com/read/29570389/anterior-two-thirds-corpus-callosotomy-via-stereotactic-laser-ablation
#19
Michael Karsy, Daxa M Patel, Kyle Halvorson, Vance Mortimer, Robert J Bollo
Anterior two-thirds corpus callosotomy is a common palliative surgical intervention most commonly employed in patients with atonic or drop seizures. Recently, stereotactic laser ablation of the corpus callosum without a craniotomy has shown promise in achieving similar outcomes with fewer side effects and shorter hospitalizations. The authors demonstrate ablation of the anterior two-thirds corpus callosum in a patient with Lennox-Gastaut syndrome and drug-resistant drop seizures. Technical nuances of laser ablation with 3 laser fibers are described...
April 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29570386/laser-interstitial-thermal-therapy-for-an-eloquent-region-supratentorial-brain-lesion
#20
Mayur Sharma, Daria Krivosheya, Hamid Borghei-Razavi, Gene H Barnett, Alireza M Mohammadi
Laser interstitial thermal therapy (LITT) is a minimally invasive stereotactic technique that causes tumor ablation using thermal energy. LITT has shown to be efficacious for the treatment of deep-seated brain lesions, including those near eloquent areas. In this video, the authors present the case of a 62-year-old man with a history of metastatic melanoma who presented with worsening right-sided hemiparesis. MRI revealed a contrast-enhancing lesion in left centrum semiovale in close proximity to corticospinal tracts, consistent with radiation necrosis...
April 2018: Neurosurgical Focus
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