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https://www.readbyqxmd.com/read/29148813/stitching-oxindoles-and-ynones-in-a-domino-process-access-to-spirooxindoles-and-application-to-a-short-synthesis-of-spindomycin-b
#1
Ramesh Samineni, Jaipal Madapa, Srihari Pabbaraja, Goverdhan Mehta
A general, transition-metal-free, one-pot, domino Michael-SNAr or AdNE substitution protocol was devised for spiroannulation of oxindoles with ortho-bromoaryl ynones, β-bromoalkenyl ynones, and β-bromoalkenyl enones in a convenient and efficient manner. As an application, a short synthesis of tetracyclic alkaloid spindomycin B was accomplished.
November 17, 2017: Organic Letters
https://www.readbyqxmd.com/read/29132545/nanoformulation-a-useful-therapeutic-strategy-for-improving-neuroprotection-and-the-neurorestorative-potential-in-experimental-models-of-parkinson-s-disease
#2
Jose V Lafuente, Catalina Requejo, Alejandro Carrasco, Harkaitz Bengoetxea
Parkinson's disease (PD) is the second most frequent neurodegenerative disorder, but current therapies are only symptomatic. Experimental models are necessary to go deeper in the comprehension of pathophysiological mechanism and to assess new therapeutic strategies. The unilateral 6-hydroxydopamine (6-OHDA) lesion either in medial forebrain bundle (MFB) or into the striatum in rats affords to study various stages of PD depending on the evolution time lapsed. A promising alternative to address the neurodegenerative process is the use of neurotrophic factors; but its clinical use has been limited due to its short half-life and rapid degradation after in vivo administration, along with difficulties for crossing the blood-brain barrier (BBB)...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/29118022/tonic-aortic-depressor-nerve-stimulation-does-not-impede-baroreflex-dynamic-characteristics-concomitantly-mediated-by-the-stimulated-nerve
#3
Toru Kawada, Michael J Turner, Shuji Shimizu, Atsunori Kamiya, Toshiaki Shishido, Masaru Sugimachi
Although electrical activation of the carotid sinus baroreflex (baroreflex activation therapy) is being explored as a device therapy for resistant hypertension, possible effects on baroreflex dynamic characteristics of interaction between electrical stimulation and pressure inputs are not fully elucidated. To examine whether the electrical stimulation of the baroreceptor afferent nerve impedes normal short-term arterial pressure (AP) regulation mediated by the stimulated nerve, we electrically stimulated the right aortic depressor nerve (ADN) while estimating the baroreflex dynamic characteristics by imposing pressure inputs to the isolated baroreceptor region of the right ADN in nine anesthetized rats...
November 8, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29079430/adiponectin-modulates-synaptic-plasticity-in-hippocampal-dentate-gyrus
#4
Farideh Pousti, Ramesh Ahmadi, Fatemeh Mirahmadi, Narges Hosseinmardi, Kambiz Rohampour
Recent studies have suggested the involvement of some metabolic hormones in memory formation and synaptic plasticity. Insulin dysfunction is known as an essential process in the pathogenesis of sporadic Alzheimer's disease (AD). In this study we examined whether adiponectin (ADN), as an insulin-sensitizing adipokine, could affect hippocampal synaptic plasticity. Field potential recordings were performed on intracerebroventricular (icv) cannulated urethane anesthetized rats. After baseline recording from dentate gyrus (DG) and 10min prior to high/low frequency stimulation (HFS/LFS), 10μl icv ADN (600nm) were injected...
October 25, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29039854/sugar-hydrazide-imides-a-new-family-of-glycosidase-inhibitors
#5
Emil Lindbäck, Óscar Lopéz, Ådne Tobiesen, José G Fernández-Bolaños, Magne O Sydnes
The preparation of a novel type of iminosugar including a hydrazide imide moiety is described. The sugar hydrazide imides (3S,4S,5R,6R)-1-amino-3,4,5-trihydroxy-6-(hydroxymethyl)-2-iminopiperidine acetate and (3S,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-imino-1-(methylamino)piperidine acetate presented here behave as inhibitors of α/β-glucosidases in the low micromolar concentration range. The former inhibitor displays a pH-dependent inhibition of β-glucosidase. The N-methylated counterpart behaves as an anomer-selective competitive micromolar inhibitor of α-glucosidase...
October 25, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28869339/anodic-dissolution-of-al-current-collectors-in-unconventional-solvents-for-high-voltage-electrochemical-double-layer-capacitors
#6
Jakob Krummacher, Lars Henning Hess, Andrea Balducci
This study investigated the anodic dissolution of Al current collectors in unconventional electrolytes for high voltage electrochemical double layer capacitors (EDLC) containing adiponitrile (ADN), 3-cyanopropionic acid methyl ester (CPAME), 2-methyl-glutaronitrile (2-MGN) as solvent, and tetraethylammonium tetrafluroroborate (Et4NBF4) and tetraethylammonium bis(trifluoromethanesulfonyl)imide (Et4NTFSI) as conductive salts. In order to have a comparison with the state-of-the-art electrolytes, the same salts were also used in combination with acetonitrile (ACN)...
September 4, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28843175/who-s-uncivil-to-who-perceptions-of-incivility-in-pre-licensure-nursing-programs
#7
Karen Aul
The purpose of this study was to determine if there were differences in the perceptions of uncivil behaviors among nursing students and faculty according to pre-licensure nursing program types, and if there were any relationships in reported uncivil behaviors to the variables of age, gender, ethnic/racial background, and parental level of education. The sample was a convenience sample of 159 pre-licensure senior nursing students and 14 nursing faculty from four schools of nursing in the northeastern United States: two Bachelor of Science in Nursing (BSN) programs, one Associate Degree in Nursing (ADN) program, and one hospital-based diploma nursing program...
November 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/28817520/renew-wyoming-s-answer-to-academic-progression-in-nursing
#8
Jennifer Anderson, Kathy Wells, Charlotte Mather, Mary E Burman
AIM: The aim of the study was to describe Wyoming's approach to academic progression and its projected impact. The collaborative process used to develop the shared statewide BSN curriculum is described along with recommendations. BACKGROUND: Successful educational models that address the Institute of Medicine's recommendation that 80 percent of RNs have a baccalaureate degree by 2020 face numerous challenges, especially in rural states. METHOD: ReNEW (Revolutionizing Nursing Education in Wyoming) is a creative solution designed to decrease barriers to BSN education and increase motivation through a streamlined shared curriculum building on a strong community college system and the state's one BSN program...
September 2017: Nursing Education Perspectives
https://www.readbyqxmd.com/read/28683257/retrograde-lymph-flow-leads-to-chylothorax-in-transgenic-mice-with-lymphatic-malformations
#9
Maximilian Nitschké, Alexander Bell, Sinem Karaman, Meelad Amouzgar, Joseph M Rutkowski, Philipp E Scherer, Kari Alitalo, Donald M McDonald
Chylous pleural effusion (chylothorax) frequently accompanies lymphatic vessel malformations and other conditions with lymphatic defects. Although retrograde flow of chyle from the thoracic duct is considered a potential mechanism underlying chylothorax in patients and mouse models, the path chyle takes to reach the thoracic cavity is unclear. Herein, we use a novel transgenic mouse model, where doxycycline-induced overexpression of vascular endothelial growth factor (VEGF)-C was driven by the adipocyte-specific promoter adiponectin (ADN), to determine how chylothorax forms...
September 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28683030/testing-for-quality-and-safety-education-for-nurses-qsen-reflections-from-using-qsen-as-a-framework-for-rn-orientation
#10
David H James, Patricia A Patrician, Rebecca S Miltner
The use of the Quality and Safety Education for Nurses (QSEN) competencies for nursing professional development is in its infancy. QSEN content was incorporated into nursing orientation and tested knowledge gain for three QSEN competencies. Results showed an increase in patient safety knowledge. A difference was noted in knowledge between ADN and BSN nurses for evidence-based practice and quality improvement. The results indicate a need for stronger interventions to build practicing nurses' QSEN competencies...
July 2017: Journal for Nurses in Professional Development
https://www.readbyqxmd.com/read/28562401/using-a-standardized-patient-to-improve-collaboration-and-problem-solving-skills-with-cpap-usage-in-the-home
#11
Margaret G Williams, Joan Ruhs
A review of literature revealed a lack of research pertaining to nurses' or student nurses' knowledge of continuous positive airway pressure (CPAP) and the ability to troubleshoot CPAP malfunction. This study sought to answer the following questions: What are associate degree nursing (ADN) students' knowledge, interdisciplinary communication, and problem-solving skills regarding patients' home use of CPAP? Is there a change after participation in a simulation with a patient on CPAP in home setting? Twenty-one ADN students enrolled in small Midwest college participated...
June 2017: Home Healthcare Now
https://www.readbyqxmd.com/read/28438631/in-vivo-inhibitory-activity-of-andrographolide-derivative-adn-9-against-liver-cancer-and-its-mechanisms-involved-in-inhibition-of-tumor-angiogenesis
#12
Wei Yang, Jin Zhao, Yake Wang, Haiwei Xu, Zhenwei Wu, Yangyang Hu, Kunkun Jiang, Pengpeng Shen, Cuiyun Ma, Zhenzhen Guan, Yan Zhang, Jiahui Ma, Ning Shang, Guangming Yan, Zhenji Wang, Guifu Dai
It is well known that liver cancer is a highly aggressive malignancy with poor prognosis. Andrographolide (AD), a major bioactive component of Andrographis paniculata (Burm. F.), is a potential anti-cancer pharmacophore and the synthesis of AD derivatives with better cytotoxicity to cancer cells has attracted considerable attentions. In the present study, we evaluated the in vivo inhibitory effects of ADN-9, a 15-benzylidene substituted derivative of AD, on the growth and metastasis of murine hepatoma H22 using an orthotopic xenograft model and a subcutaneous xenograft model, and we further studied the anti-angiogenic action and the related mechanisms of ADN-9 in vivo and in vitro...
July 15, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28395518/intracerebroventricular-administration-of-adiponectin-attenuates-streptozotocin-induced-memory-impairment-in-rats
#13
R Mazrooie, K Rohampour, M Zamani, N Hosseinmardi, M Zeraati
Alzheimer's disease (AD) has been reported to be linked with diabetes mellitus and insulin resistance. Adiponectin (ADN), an adipocytokine secreted from adipose tissue, is involved in the regulation of insulin sensitivity, energy homeostasis, and mitochondrial dysfunction. In this study, we examined the effect of ADN on passive avoidance memory in animal model of sporadic AD (sAD). On days 1 and 3 after cannulation, rats received intracerebroventricular (icv) injection of streptozotocin (STZ) (3 mg/kg). Thirty minutes before the learning process, animals received saline or ADN in different doses (6, 60, and 600 µg)...
June 1, 2017: Physiology International
https://www.readbyqxmd.com/read/28351714/evaluation-of-environmental-and-nutritional-factors-and-sua-gene-on-in%C3%A2-vitro-biofilm-formation-of-streptococcus-uberis-isolates
#14
Melina Vanesa Moliva, Florencia Cerioli, Elina Beatriz Reinoso
The pathogenesis of Streptococcus uberis is attributed to a combination of extracellular factors and properties such as adherence and biofilm formation. The aim of this work was to evaluate the influence of different factors, additives and bovine milk compounds on S. uberis biofilm formation, as the presence of the sua gene by PCR. Additionally, extracellular DNA and the effect of DNaseI were evaluated in the biofilms yielded. Optimal biofilm development was observed when the pH was adjusted to 7.0 and 37 °C...
June 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28291828/retinoic-acid-exacerbates-chlorpyrifos-action-in-ensuing-adipogenic-differentiation-of-c3h10t%C3%A2-cells-in-a-gsk3%C3%AE-dependent-pathway
#15
Harkirat Singh Sandhu, A J S Bhanwer, Sanjeev Puri
The cell differentiation can be exploited as a paradigm to evaluate the effects of noxious chemicals, on human health, either alone or in combinations. In this regard, the effect of a known cell differentiation agent, retinoic acid (RA) was analyzed in the presence of a noxious chemical chlorpyrifos (CPF), an organophosphate (OP), the receptors of which have recently been localized to mesenchymal stem cells (MSCs). The observed imbalance of adipogenic to skeletal differentiation by CPF together with conundrum about adipogenic potential of RA prompted us to delineate their combinatorial effects on C3H10T½MSC-like undifferentiated cells...
2017: PloS One
https://www.readbyqxmd.com/read/28274940/aortic-depressor-nerve-stimulation-does-not-impede-the-dynamic-characteristics-of-the-carotid-sinus-baroreflex-in-normotensive-or-spontaneously-hypertensive-rats
#16
Toru Kawada, Michael J Turner, Shuji Shimizu, Masafumi Fukumitsu, Atsunori Kamiya, Masaru Sugimachi
Recent clinical trials in patients with drug-resistant hypertension indicate that electrical activation of the carotid sinus baroreflex can reduce arterial pressure (AP) for more than a year. To examine whether the electrical stimulation from one baroreflex system impedes normal short-term AP regulation via another unstimulated baroreflex system, we electrically stimulated the left aortic depressor nerve (ADN) while estimating the dynamic characteristics of the carotid sinus baroreflex in anesthetized normotensive Wistar-Kyoto (WKY; n = 8) rats and spontaneously hypertensive rats (SHR; n = 7)...
May 1, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28274116/exciplex-sensitized-triplet-triplet-annihilation-in-heterojunction-organic-thin-film
#17
Bo-Yen Lin, Connor J Easley, Chia-Hsun Chen, Po-Chen Tseng, Ming-Zer Lee, Pin-Hao Sher, Juen-Kai Wang, Tien-Lung Chiu, Chi-Feng Lin, Christopher J Bardeen, Jiun-Haw Lee
A new concept for organic light-emitting diodes (OLEDs) is presented, which is called exciplex-sensitized triplet-triplet annihilation (ESTTA). The exciplex formed at the organic heterojunction interface of 4,4',4″-tris(N-3-methyphenyl-N-phenyl-amino) triphenylamine and 9,10-bis(2'-naphthyl) anthracene (ADN) is used to sensitize the triplet-triplet annihilation (TTA) process on the ADN molecules. This results in a turn-on voltage (2.2 V) of the blue emission from the OLED below the bandgap (2.9 eV). From the transient electroluminescence measurement, blue emission totally came from the TTA process without direct recombination on the ADN molecules...
March 29, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28269263/a-wireless-system-with-stimulation-and-recording-capabilities-for-interfacing-peripheral-nerves-in-rodents
#18
P Schonle, F Michoud, N Brun, A Guex, S P Lacour, Q Wang, Q Huang
Considerable progress has been made in the last decade in implantable bioelectronic neurosystems. Yet most neural implants are used in acute and tethered experimental conditions. Here, we present a preliminary prototype of a multichannel system for simultaneous peripheral nerve stimulation and neural recording. The system comprises miniaturized electronics with a total volume of less then 1.4cm3 including a 3.7V battery which is expected to last for 94 days of standby operation or 18 hours of continuous recording and stimulation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28263358/writing-development-in-associate-degree-in-nursing-to-baccalaureate-degree-in-nursing-students-moving-out-of-the-comfort-zone
#19
Deborah E Tyndall, Elaine S Scott
BACKGROUND: The nursing profession has made several unsuccessful attempts to differentiate practice between nurses with associate degrees and baccalaureate degrees entering the workforce. Writing competency has been identified as one potential area of differentiation. METHOD: A descriptive, qualitative research design was used to explore Associate Degree in Nursing-to-Baccalaureate Degree in Nursing (ADN-to-BSN) graduates' perceptions of scholarly writing development in their baccalaureate studies...
March 1, 2017: Journal of Nursing Education
https://www.readbyqxmd.com/read/28261588/comparison-of-visceral-fat-accumulation-and-metabolome-markers-among-cats-of-varying-bcs-and-novel-classification-of-feline-obesity-and-metabolic-syndrome
#20
Yuki Okada, Motoo Kobayashi, Masaki Sawamura, Toshiro Arai
As in humans, obesity and its associated diseases represent the most significant threat to the health of veterinary populations. Previous human studies have provided insights into the risk factors of obesity, complex pathogenesis of obesity-associated diseases, and their life-threatening consequences. In humans, the "metabolic syndrome" represents a cluster of metabolic risk factors associated with the development of cardiovascular disease. Risk factors for metabolic syndrome, such as diabetes, obesity, high blood pressure, and its complications increase health-care utilization and medical expenses...
2017: Frontiers in Veterinary Science
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