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https://www.readbyqxmd.com/read/27844282/morphological-changes-in-a-severe-model-of-parkinson-s-disease-and-its-suitability-to-test-the-therapeutic-effects-of-microencapsulated-neurotrophic-factors
#1
C Requejo, J A Ruiz-Ortega, H Bengoetxea, A García-Blanco, E Herrán, A Aristieta, M Igartua, J L Pedraz, L Ugedo, R M Hernández, J V Lafuente
The unilateral 6-hydroxydopamine (6-OHDA) lesion of medial forebrain bundle (MFB) in rats affords us to study the advanced stages of Parkinson's disease (PD). Numerous evidences suggest synergic effects when various neurotrophic factors are administered in experimental models of PD. The aim of the present work was to assess the morphological changes along the rostro-caudal axis of caudo-putamen complex and substantia nigra (SN) in the referred model in order to test the suitability of a severe model to evaluate new neurorestorative therapies...
November 14, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27709932/azole-functionalized-polyoxo-titanium-clusters-with-sunlight-driven-dye-degradation-applications-synthesis-structure-and-photocatalytic-studies
#2
Nagaraju Narayanam, Kalpana Chintakrinda, Wei-Hui Fang, Yao Kang, Lei Zhang, Jian Zhang
Six polyoxo-titanium clusters (PTCs) with varying nuclearities containing Ti-N bonds and heteronuclearity, namely, [Ti6(μ3-O)2(μ2-O)2(O3P-Phen)2(OiPr)10(1-hbta)2] (PTC-37), Ti8(μ3-O)2(μ2-O)2(O3P-Phen)2(OiPr)16(adn)2(NO3)2] (PTC-38), [Ti4(μ3-O)(μ2-O)(μ2-OiPr)2(OiPr)4(O3P-Phen)3(1,10-phn)](HOiPr) (PTC-39), [Ti4(μ3-O)(μ2-OiPr)3(OiPr)5(O3P-Phen)3(Im)] (PTC-40), [Ti4(μ3-O)(μ2-OiPr)3(OiPr)5(O3P-Phen)3(Im)][Ti3M(μ3-O)(μ2-OiPr)3(OiPr)3(O3P-Phen)3(Im)] (M = Co for PTC-41 and M = Zn for PTC-42; O3P-Phen = phenyl phosphonate, 1-hbta = 1-hydroxy benzotriazolate, adn = adenine, 1,10-phn = 1,10-phenanthroline, Im = imidazolate, and OiPr = isopropoxide) were prepared as crystalline samples and structurally characterized...
October 6, 2016: Inorganic Chemistry
https://www.readbyqxmd.com/read/27676325/the-effect-of-chronic-activation-of-the-novel-endocannabinoid-receptor-gpr18-on-myocardial-function-and-blood-pressure-in-conscious-rats
#3
Asmaa I Matouk, Ashraf Taye, Mohamed A El-Moselhy, Gehan H Heeba, Abdel A Abdel-Rahman
While acute activation of the novel endocannabinoid receptor GPR18 causes hypotension, there are no reports on GPR18 expression in the heart or its chronic modulation of cardiovascular function. In this study, after demonstrating GPR18 expression in the heart, we show that chronic (2 weeks) GPR18 activation with its agonist abnormal cannabidiol (abn-cbd; 100 µg/kg/day; i.p) produced hypotension, suppressed the cardiac sympathetic dominance, and improved left ventricular (LV) function (increased the contractility index dp/dtmax, and reduced LV end diastolic pressure, LVEDP) in conscious rats...
September 20, 2016: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/27663135/disinhibition-of-neurons-of-the-nucleus-of-solitary-tract-that-project-to-the-superior-salivatory-nucleus-causes-choroidal-vasodilation-implications-for-mechanisms-underlying-choroidal-baroregulation
#4
Chunyan Li, Malinda E C Fitzgerald, Nobel Del Mar, Anton Reiner
Preganglionic neurons in the superior salivatory nucleus (SSN) that mediate parasympathetic vasodilation of choroidal blood vessels receive a major excitatory input from the baroresponsive part of the nucleus of the solitary tract (NTS). This input appears likely to mediate choroidal vasodilation during systemic hypotension, which prevents decreases in choroidal blood flow (ChBF) due to reduced perfusion pressure. It is uncertain, however, how low blood pressure signals to NTS from the aortic depressor nerve (ADN), which fires at a low rate during systemic hypotension, could yield increased firing in the NTS output to SSN...
October 28, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27514756/adiponectin-suppresses-t-helper-17-cell-differentiation-and-limits-autoimmune-cns-inflammation-via-the-sirt1-ppar%C3%AE-ror%C3%AE-t-pathway
#5
Kai Zhang, Yawei Guo, Zhenzhen Ge, Zhihui Zhang, Yurong Da, Wen Li, Zimu Zhang, Zhenyi Xue, Yan Li, Yinghui Ren, Long Jia, Koon-Ho Chan, Fengrui Yang, Jun Yan, Zhi Yao, Aimin Xu, Rongxin Zhang
T helper 17 (Th17) cells are vital components of the adaptive immune system involved in the pathogenesis of most autoimmune and inflammatory syndromes, and adiponectin(ADN) is correlated with inflammatory diseases such as multiple sclerosis (MS) and type II diabetes. However, the regulatory effects of adiponectin on pathogenic Th17 cell and Th17-mediated autoimmune central nervous system (CNS) inflammation are not fully understood. In this study, we demonstrated that ADN could inhibit Th1 and Th17 but not Th2 cells differentiation in vitro...
August 11, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27508715/-op-4c-10-clinically-important-differences-in-systolic-ambulatory-blood-pressure-in-patients-switched-between-alternate-nifedipine-osmotic-delivery-formulations
#6
P T Pollak, R J Herman, R D Feldman
OBJECTIVE: Anecdotal evidence suggested clinically important systolic blood pressure (SBP) differences occurred in our patients whose nifedipine was being switched by pharmacies between AdN (Adalat XL - a formulation providing zero order release from the GastroIntestinal Therapeutic System - GITS) and MyN (Mylan-nifedipine ER - a formulation providing a delayed first-order release from the Osmotic Release Oral System - OROS). In vitro dissolution studies showed greater lag time to initial release from MyN and declining release at end of dosing interval...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27391323/co-morbidity-of-personality-disorder-in-schizophrenia-among-psychiatric-outpatients-in-china-data-from-epidemiologic-survey-in-a-clinical-population
#7
YanYan Wei, TianHong Zhang, Annabelle Chow, YingYing Tang, LiHua Xu, YunFei Dai, XiaoHua Liu, Tong Su, Xiao Pan, Yi Cui, ZiQiang Li, KaiDa Jiang, ZePing Xiao, YunXiang Tang, JiJun Wang
BACKGROUND: The reported rates of personality disorder (PD) in subjects with schizophrenia (SZ) are quite varied across different countries, and less is known about the heterogeneity of PD among subjects with SZ. We examined the co-morbidity of PD among patients who are in the stable phase of SZ. METHOD: 850 subjects were randomly sampled from patients diagnosed with SZ in psychiatric and psycho-counseling clinics at Shanghai Mental Health Center. Co-morbidity of PDs was assessed through preliminary screening and patients were administered several modules of the SCID-II...
2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27364509/perioperative-adiponectin-measurement-is-useful-for-prediction-of-postoperative-infection-in-patients-with-colorectal-cancer
#8
Hiroshi Yamamoto, Kazuhisa Maeda, Hisatomi Arima, Hiromichi Sonoda, Tomoharu Shimizu, Eiji Mekata, Sachiko Kaida, Tsuyoshi Yamaguchi, Satoshi Murata, Katsuyuki Miura, Makoto Kadowaki, Masaji Tani
BACKGROUND: Adiponectin (ADN) is a key molecule associated with obesity and metabolic syndrome, and functions as an immunomodulator. We have shown that the ADN ratio (i.e., postoperative ADN/preoperative ADN) can predict infection after gastrectomy in patients with gastric cancer . In the present study, we evaluated whether the ADN ratio could reliably predict the incidence of postoperative infection in patients undergoing colorectal cancer surgery. METHODS: We retrospectively analyzed 131 consecutive patients who underwent colorectal cancer surgery and measured their preoperative and postoperative ADN values...
August 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27346781/influence-of-clonidine-on-antihypertensive-selective-afferent-vagal-nerve-stimulation-in-rats
#9
Mortimer Gierthmuehlen, Debora Aguirre, Oscar Cota, Josef Zentner, Thomas Stieglitz, Dennis T T Plachta
OBJECTIVE: Selective-afferent vagal nerve stimulation (sVNS) may be a treatment option for therapy-resistant hypertension, as it lowers blood pressure (BP) in rats without causing significant side effects. Alpha-2-agonists are widely used for the treatment of withdrawal, chronic pain and other disorders, and even if sVNS becomes a treatment option for therapy resistant hypertension, in some patients it might be necessary to combine sVNS with an alpha-2-agonist like clonidine. Alpha-2-agonists exhibit a central and peripheral mechanism of action...
August 2016: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/27216125/hiring-intentions-of-directors-of-nursing-programs-related-to-dnp-and-phd-prepared-faculty-and-roles-of-faculty
#10
Marilyn H Oermann, Mary R Lynn, Charlotte A Agger
This study surveyed administrators of associate degree in nursing (ADN) and bachelor of science in nursing (BSN) programs across the United States to identify hiring intentions and describe the roles and responsibilities of DNP- and PhD-prepared faculty members. The final sample included 253 ADN and 229 BSN programs. ADN programs were neither intentionally hiring nor looking to hire doctorally prepared nurse faculty. Deans and directors of BSN programs reported an average of 3 openings for the next academic year, 2 projected for new PhD-prepared faculty and 1 for a faculty member with a DNP...
May 2016: Journal of Professional Nursing: Official Journal of the American Association of Colleges of Nursing
https://www.readbyqxmd.com/read/27180964/-treatment-of-nephrotic-syndrome-immuno-or-rather-podocyte-therapy
#11
Barbara Lewko
Nephrotic syndrome (NS) is a group of clinical symptoms resulting from massive proteinuria caused by impairment of the glomerular filtration barrier. The filtration barrier comprises glomerular basement membrane with endothelial cells lining its inner side and a podocyte monolayer covering its outer aspect. As well as forming part of the glomerular filter, podocytes also regulate synthesis of other components of the filtration barrier. Therefore, integrity of these cells is crucial for maintaining the normal ultrafiltration function...
2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/27152881/remarkable-adsorptive-removal-of-nitrogen-containing-compounds-from-a-model-fuel-by-a-graphene-oxide-mil-101-composite-through-a-combined-effect-of-improved-porosity-and-hydrogen-bonding
#12
Imteaz Ahmed, Sung Hwa Jhung
A composite was prepared by combining a highly porous metal-organic framework (MOF), MIL-101 (Cr-benzenedicarboxylate), and graphene oxide (GnO). The porosity of the composite increased appreciably by the addition of GnO up to a specific amount in the MOF, though further increases in the quantity of GnO was detrimental to porosity. The improved porosity of the GnO/MIL-101 composite was utilized for adsorptive denitrogenation (ADN) of a model fuel where indole (IND) and quinoline (QUI) were used as nitrogen-containing compounds (NCCs)...
August 15, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/26989296/effect-of-deoxycorticosterone-acetate-salt-induced-hypertension-on-diabetic-peripheral-neuropathy-in-alloxan-induced-diabetic-wbn-kob-rats
#13
Kiyokazu Ozaki, Hiroko Hamano, Tetsuro Matsuura, Isao Narama
The relationship between hypertension and diabetic peripheral neuropathy (DPN) has recently been reported in clinical research, but it remains unclear whether hypertension is a risk factor for DPN. To investigate the effects of hypertension on DPN, we analyzed morphological features of peripheral nerves in diabetic rats with hypertension. Male WBN/Kob rats were divided into 2 groups: alloxan-induced diabetic rats with deoxycorticosterone acetate-salt (DOCA-salt) treatment (ADN group) and nondiabetic rats with DOCA-salt treatment (DN group)...
January 2016: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/26979176/adn-1184-a-monoaminergic-ligand-with-5-ht6-7-receptor-antagonist-action-exhibits-activity-in-animal-models-of-anxiety
#14
Anna Partyka, Anna Wasik, Magdalena Jastrzębska-Więsek, Paweł Mierzejewski, Przemysław Bieńkowski, Marcin Kołaczkowski, Anna Wesołowska
Behavioral and psychological symptoms of dementia (BPSD) include apathy, sleep problems, irritability, wandering, elation, agitation/aggression, and mood disorders such as depression and/or anxiety. Elderly patients are usually treated with second-generation antipsychotics; however, they present not enough efficacy against all symptoms observed. Hence, there still is an unmet need for novel pharmacotherapeutic agents targeted BPSD. A novel arylsulfonamide derivative ADN-1184 has been developed that possesses a preclinical profile of activity corresponding to criteria required for treatment of both psychosis and depressive symptoms of BPSD without exacerbating cognitive impairment or inducing motor disturbances...
June 2016: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/26919615/co-localization-of-ki67-cd44v-adn-deltanp63-in-the-invasive-front-of-lung-squamous-cell-carcinoma
#15
Shotaro Yamano, Min Gi, Yoshiyuki Tago, Kenichiro Doi, Satoshi Okada, Yukiyoshi Hirayama, Hirokazu Tachibana, Naomi Ishii, Masaki Fujioka, Kumiko Tatsumi, Hideki Wanibuchi
No abstract text is available yet for this article.
February 2016: Cancer Science
https://www.readbyqxmd.com/read/26876918/cardiovascular-responses-elicited-by-continuous-versus-intermittent-electrical-stimulation-of-the-aortic-depressor-nerve-in-conscious-rats
#16
COMPARATIVE STUDY
Fernanda Brognara, Daniel P Martins Dias, Jaci A Castania, Rubens Fazan, Stephen J Lewis, Helio C Salgado
AIMS: Short-term (seconds or minutes) continuous electrical activation of the aortic depressor nerve (ADN) in conscious rats has been successfully used to investigate baroafferent function in experimental hypertension, heart failure, and peripheral inflammation. The aim of this study was to characterize the hemodynamic responses elicited by longer periods (60min) of continuous or intermittent electrical baroreflex activation. MAIN METHODS: Wistar rats were implanted with an electrode around the left ADN and a catheter into a femoral artery...
March 1, 2016: Life Sciences
https://www.readbyqxmd.com/read/26862685/rn-bsn-students-perceptions-of-the-differences-in-practice-of-the-adn-and-bsn-prepared-rn
#17
April D Matthias, Yeoun Soo Kim-Godwin
This study explored RN-BSN students' perceptions of practice differences between nurses prepared with an ADN and BSN. Five themes were identified in 20 students' discussion posts: "a nurse is a nurse" at the bedside, beyond the bedside, BSN wanted, digging deeper, and appraisal. Results illustrate the need for educators to assist nurses in translating the differentiated educational competencies to the practice role of the bedside RN.
July 2016: Nurse Educator
https://www.readbyqxmd.com/read/26845822/california-collaborative-model-for-nursing-education-building-a-higher-educated-nursing-workforce
#18
Deloras Jones, Liz Close
The California Collaborative Model for Nursing Education (CCMNE) promotes seamless ADN-BSN academic progression as the most effective means by which the state can educate the numbers of BSN-prepared nurses needed in the future. Accelerated by state legislation and a national commitment to a higher-educated nursing workforce, the framework is sufficiently flexible to accommodate a variety of strategies that meet the intent of each Core Component, and can be implemented at local, regional, or state levels. Six percent of all current ADN students in California are dual enrolled in CCMNE BSN programs...
November 2015: Nursing Economic$
https://www.readbyqxmd.com/read/26843582/electrical-stimulation-of-the-aortic-depressor-nerve-in-conscious-rats-overcomes-the-attenuation-of-the-baroreflex-in-chronic-heart-failure
#19
Tomás O C Teixeira Pinto, Renata M Lataro, Jaci A Castania, Marina T Durand, Carlos A A Silva, Kaushik P Patel, Rubens Fazan, Helio C Salgado
Chronic heart failure (CHF) is characterized by autonomic dysfunction combined with baroreflex attenuation. The hypotensive and bradycardic responses produced by electrical stimulation of the aortic depressor nerve (ADN) were examined in conscious CHF and control male Wistar rats (12-13 wk old). Furthermore, the role of parasympathetic and sympathetic nervous system in mediating the cardiovascular responses to baroreflex activation was evaluated by selective β1-adrenergic and muscarinic receptor antagonists...
April 1, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/26835186/phylogeography-of-arabidopsis-halleri-brassicaceae-in-mountain-regions-of-central-europe-inferred-from-cpdna-variation-and-ecological-niche-modelling
#20
Pawel Wasowicz, Maxime Pauwels, Andrzej Pasierbinski, Ewa M Przedpelska-Wasowicz, Alicja A Babst-Kostecka, Pierre Saumitou-Laprade, Adam Rostanski
The present study aimed to investigate phylogeographical patterns present within A. halleri in Central Europe. 1,281 accessions sampled from 52 populations within the investigated area were used in the study of genetic variation based on chloroplast DNA. Over 500 high-quality species occurrence records were used in ecological niche modelling experiments. We evidenced the presence of a clear phylogeographic structure within A. halleri in Central Europe. Our results showed that two genetically different groups of populations are present in western and eastern part of the Carpathians...
2016: PeerJ
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