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https://www.readbyqxmd.com/read/29326116/behavioural-responses-to-infrasonic-particle-acceleration-in-cuttlefish
#1
Maria Wilson, Jens Ådne Rekkedal Haga, Hans Erik Karlsen
Attacks by aquatic predators generate frontal water disturbances characterised by low-frequency gradients in pressure and particle motion. Low-frequency hearing is highly developed in cephalopods. Thus, we examined behavioural responses in juvenile cuttlefish to infrasonic accelerations mimicking main aspects of the hydrodynamic signals created by predators. In the experimental set-up, animals and their surrounding water moved as a unit to minimise lateral line activation and to allow examination of the contribution by the inner ear...
January 11, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29300298/supported-ni-catalyst-for-liquid-phase-hydrogenation-of-adiponitrile-to-6-aminocapronitrile-and-hexamethyenediamine
#2
Chengqiang Wang, Zekun Jia, Bin Zhen, Minghan Han
Supported Ni catalysts prepared under different conditions, for liquid phase hydrogenation of adiponitrile (ADN) to 6-aminocapronitrile (ACN) and hexamethyenediamine (HMD), were investigated. The highly reactive imine intermediate can form condensation byproducts with primary amine products (ACN and HMD), which decreased the yield coefficient of primary amines. The catalysts support, condition of catalyst preparation and dosage of additive were studied to improve the yield. A highly dispersed Ni/SiO₂ catalyst prepared by the direct reduction of Ni(NO₃)₂/SiO₂ suppressed the condensation reactions by promoting the hydrogenation of adsorbed imines, and it gave the improved hydrogenation activity of 0...
January 4, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29277251/-characterization-of-the-genetic-variability-of-field-strains-of-brucella-canis-isolated-in-antioquia
#3
Juana L Vidal Arboleda, Luisa F Ortiz Roman, Martha Olivera Angel
Brucella canis is a facultative intracellular pathogen responsible for canine brucellosis, a zoonotic disease that affects canines, causing abortions and reproductive failure; and the production of non-specific symptoms in humans. In 2005 the presence of B. canis in Antioquia was demonstrated and the strains were identified as type 2. The sequencing of the genome of a field strain denoted Brucella canis str. Oliveri, showed species-specific indel events, which led us to investigate the genomic characteristics of the B...
December 22, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/29274332/abnormal-cannabidiol-confers-cardioprotection-in-diabetic-rats-independent-of-glycemic-control
#4
Asmaa I Matouk, Ashraf Taye, Mohamed A El-Moselhy, Gehan H Heeba, Abdel A Abdel-Rahman
Chronic GPR18 activation by its agonist abnormal cannabidiol (trans-4-[3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol; abn-cbd) improves myocardial redox status and function in healthy rats. Here, we investigated the ability of abn-cbd to alleviate diabetes-evoked cardiovascular pathology and the contribution of GPR18 to this effect. Four weeks after diabetes induction by streptozotocin (STZ, 55mg/kg; i.p), male Wistar rats received abn-cbd, the GPR18 antagonist (1,3-dimethoxy-5-methyl-2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-,cyclohexen-1-yl]benzene;O-1918), their combination (100µg/kg/day, i...
December 20, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29243561/patient-safety-communication-among-differently-educated-nurses-converging-and-diverging-meaning-systems
#5
Allison Brandt Anbari, Amy Vogelsmeier, Debbie S Dougherty
Studies that suggest an increased number of bachelor's prepared nurses (BSNs) at the bedside improves patient safety do not stratify their samples into traditional bachelor's and associates (ADN) to BSN graduates. This qualitative study investigated potential differences in patient safety meaning among BSNs and ADN to BSN graduates. Guided by the theory of Language Convergence/Meaning Divergence, interview data from eight BSN and eight ADN to BSN graduates were analyzed. Findings indicate there are two meaning levels or systems, the local level and the systemic level...
December 1, 2017: Western Journal of Nursing Research
https://www.readbyqxmd.com/read/29215742/effects-of-small-interfering-rna-targeting-tlr4-on-expressions-of-adipocytokines-in-obstructive-sleep-apnea-hyponea-syndrome-with-hypertension-in-a-rat-model
#6
Jing-Guo Wu, Nan Xun, Li-Jin Zeng, Zhen-Yu Li, Yan-Bing Liang, Hao Tang, Zhong-Fu Ma
We explored the effects of RNA interference-mediated silencing of TLR4 gene on expressions of adipocytokines in obstructive sleep apnea hyponea syndrome (OSAS) with hypertension in a rat model. Systolic blood pressure of caudal artery and physiological changes were observed when establishing rat models of OSAS with hypertension. Mature rat adipocytes were induced from separated and cultured primary rat adipocytes. To transfect rat mature adipocytes, TLR4 siRNA group and negative control (NC) siRNA group were established...
December 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29209593/analysis-of-the-salivary-gland-transcriptome-of-unfed-and-partially-fed-amblyomma-sculptum-ticks-and-descriptive-proteome-of-the-saliva
#7
Eliane Esteves, Sandra R Maruyama, Rebeca Kawahara, André Fujita, Larissa A Martins, Adne A Righi, Francisco B Costa, Giuseppe Palmisano, Marcelo B Labruna, Anderson Sá-Nunes, José M C Ribeiro, Andréa C Fogaça
Ticks are obligate blood feeding ectoparasites that transmit a wide variety of pathogenic microorganisms to their vertebrate hosts. Amblyomma sculptum is vector of Rickettsia rickettsii, the causative agent of Rocky Mountain spotted fever (RMSF), the most lethal rickettsiosis that affects humans. It is known that the transmission of pathogens by ticks is mainly associated with the physiology of the feeding process. Pathogens that are acquired with the blood meal must first colonize the tick gut and later the salivary glands (SG) in order to be transmitted during a subsequent blood feeding via saliva...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29173592/west-nile-virus-in-horses-during-the-summer-and-autumn-seasons-of-2015-and-2016-portugal
#8
Sílvia C Barros, Fernanda Ramos, Teresa Fagulha, Margarida Duarte, Ana Margarida Henriques, Helga Waap, Tiago Luís, Teresa Costa, Rita Amador, Sofia Quintans, Miguel Fevereiro
West Nile fever (WNF) is an emergent disease in Europe, under surveillance in the European Union. Following a 5-year period of apparent silence (autumn 2010 to summer 2015), West Nile virus (WNV) reemerged in the South of Portugal, in July 2015. Here we present data from the onset, geographic location within mainland Portugal, and outcome of clinical cases of WNV infection in horses in 2015 and 2016. During the transmission seasons of 2015 and 2016, twenty-seven horses, most symptomatic (n=20) were found positive to IgM, pr-E immunoglobulins and VNT, leading to the subsequent report to Animal Disease Notification System of the European Commission (ADNS) by the Portuguese National Authority for Animal Health...
December 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29172146/development-validation-and-application-of-a-micro-liquid-chromatography-tandem-mass-spectrometry-based-method-for-simultaneous-quantification-of-selected-protein-biomarkers-of-endothelial-dysfunction-in-murine-plasma
#9
Joanna Suraj, Anna Kurpińska, Mariola Olkowicz, Ewa Niedzielska-Andres, Magdalena Smolik, Agnieszka Zakrzewska, Agnieszka Jasztal, Barbara Sitek, Stefan Chlopicki, Maria Walczak
The objective of this study was to develop and validate the method based on micro-liquid chromatography-tandem mass spectrometry (microLC/MS-MRM) for simultaneous determination of adiponectin (ADN), von Willebrand factor (vWF), soluble form of vascular cell adhesion molecule 1 (sVCAM-1), soluble form of intercellular adhesion molecule 1 (sICAM-1) and syndecan-1 (SDC-1) in mouse plasma. The calibration range was established from 2.5pmol/mL to 5000pmol/mL for ADN; 5pmol/mL to 5000pmol/mL for vWF; 0.375pmol/mL to 250pmol/mL for sVCAM-1 and sICAM-1; and 0...
November 10, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29148813/stitching-oxindoles-and-ynones-in-a-domino-process-access-to-spirooxindoles-and-application-to-a-short-synthesis-of-spindomycin-b
#10
Ramesh Samineni, Jaipal Madapa, Srihari Pabbaraja, Goverdhan Mehta
A general, transition-metal-free, one-pot, domino Michael-SNAr or AdNE substitution protocol was devised for spiroannulation of oxindoles with ortho-bromoaryl ynones, β-bromoalkenyl ynones, and β-bromoalkenyl enones in a convenient and efficient manner. As an application, a short synthesis of tetracyclic alkaloid spindomycin B was accomplished.
November 17, 2017: Organic Letters
https://www.readbyqxmd.com/read/29132545/nanoformulation-a-useful-therapeutic-strategy-for-improving-neuroprotection-and-the-neurorestorative-potential-in-experimental-models-of-parkinson-s-disease
#11
Jose V Lafuente, Catalina Requejo, Alejandro Carrasco, Harkaitz Bengoetxea
Parkinson's disease (PD) is the second most frequent neurodegenerative disorder, but current therapies are only symptomatic. Experimental models are necessary to go deeper in the comprehension of pathophysiological mechanism and to assess new therapeutic strategies. The unilateral 6-hydroxydopamine (6-OHDA) lesion either in medial forebrain bundle (MFB) or into the striatum in rats affords to study various stages of PD depending on the evolution time lapsed. A promising alternative to address the neurodegenerative process is the use of neurotrophic factors; but its clinical use has been limited due to its short half-life and rapid degradation after in vivo administration, along with difficulties for crossing the blood-brain barrier (BBB)...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/29118022/tonic-aortic-depressor-nerve-stimulation-does-not-impede-baroreflex-dynamic-characteristics-concomitantly-mediated-by-the-stimulated-nerve
#12
Toru Kawada, Michael J Turner, Shuji Shimizu, Atsunori Kamiya, Toshiaki Shishido, Masaru Sugimachi
Although electrical activation of the carotid sinus baroreflex (baroreflex activation therapy) is being explored as a device therapy for resistant hypertension, possible effects on baroreflex dynamic characteristics of interaction between electrical stimulation and pressure inputs are not fully elucidated. To examine whether the electrical stimulation of the baroreceptor afferent nerve impedes normal short-term arterial pressure (AP) regulation mediated by the stimulated nerve, we electrically stimulated the right aortic depressor nerve (ADN) while estimating the baroreflex dynamic characteristics by imposing pressure inputs to the isolated baroreceptor region of the right ADN in nine anesthetized rats...
November 8, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29079430/adiponectin-modulates-synaptic-plasticity-in-hippocampal-dentate-gyrus
#13
Farideh Pousti, Ramesh Ahmadi, Fatemeh Mirahmadi, Narges Hosseinmardi, Kambiz Rohampour
Recent studies have suggested the involvement of some metabolic hormones in memory formation and synaptic plasticity. Insulin dysfunction is known as an essential process in the pathogenesis of sporadic Alzheimer's disease (AD). In this study we examined whether adiponectin (ADN), as an insulin-sensitizing adipokine, could affect hippocampal synaptic plasticity. Field potential recordings were performed on intracerebroventricular (icv) cannulated urethane anesthetized rats. After baseline recording from dentate gyrus (DG) and 10min prior to high/low frequency stimulation (HFS/LFS), 10μl icv ADN (600nm) were injected...
October 25, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29039854/sugar-hydrazide-imides-a-new-family-of-glycosidase-inhibitors
#14
Emil Lindbäck, Óscar Lopéz, Ådne Tobiesen, José G Fernández-Bolaños, Magne O Sydnes
The preparation of a novel type of iminosugar including a hydrazide imide moiety is described. The sugar hydrazide imides (3S,4S,5R,6R)-1-amino-3,4,5-trihydroxy-6-(hydroxymethyl)-2-iminopiperidine acetate and (3S,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-imino-1-(methylamino)piperidine acetate presented here behave as inhibitors of α/β-glucosidases in the low micromolar concentration range. The former inhibitor displays a pH-dependent inhibition of β-glucosidase. The N-methylated counterpart behaves as an anomer-selective competitive micromolar inhibitor of α-glucosidase...
October 25, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28869339/anodic-dissolution-of-al-current-collectors-in-unconventional-solvents-for-high-voltage-electrochemical-double-layer-capacitors
#15
Jakob Krummacher, Lars Henning Hess, Andrea Balducci
This study investigated the anodic dissolution of Al current collectors in unconventional electrolytes for high voltage electrochemical double layer capacitors (EDLC) containing adiponitrile (ADN), 3-cyanopropionic acid methyl ester (CPAME), 2-methyl-glutaronitrile (2-MGN) as solvent, and tetraethylammonium tetrafluroroborate (Et4NBF4) and tetraethylammonium bis(trifluoromethanesulfonyl)imide (Et4NTFSI) as conductive salts. In order to have a comparison with the state-of-the-art electrolytes, the same salts were also used in combination with acetonitrile (ACN)...
September 4, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28843175/who-s-uncivil-to-who-perceptions-of-incivility-in-pre-licensure-nursing-programs
#16
Karen Aul
The purpose of this study was to determine if there were differences in the perceptions of uncivil behaviors among nursing students and faculty according to pre-licensure nursing program types, and if there were any relationships in reported uncivil behaviors to the variables of age, gender, ethnic/racial background, and parental level of education. The sample was a convenience sample of 159 pre-licensure senior nursing students and 14 nursing faculty from four schools of nursing in the northeastern United States: two Bachelor of Science in Nursing (BSN) programs, one Associate Degree in Nursing (ADN) program, and one hospital-based diploma nursing program...
November 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/28817520/renew-wyoming-s-answer-to-academic-progression-in-nursing
#17
Jennifer Anderson, Kathy Wells, Charlotte Mather, Mary E Burman
AIM: The aim of the study was to describe Wyoming's approach to academic progression and its projected impact. The collaborative process used to develop the shared statewide BSN curriculum is described along with recommendations. BACKGROUND: Successful educational models that address the Institute of Medicine's recommendation that 80 percent of RNs have a baccalaureate degree by 2020 face numerous challenges, especially in rural states. METHOD: ReNEW (Revolutionizing Nursing Education in Wyoming) is a creative solution designed to decrease barriers to BSN education and increase motivation through a streamlined shared curriculum building on a strong community college system and the state's one BSN program...
September 2017: Nursing Education Perspectives
https://www.readbyqxmd.com/read/28683257/retrograde-lymph-flow-leads-to-chylothorax-in-transgenic-mice-with-lymphatic-malformations
#18
Maximilian Nitschké, Alexander Bell, Sinem Karaman, Meelad Amouzgar, Joseph M Rutkowski, Philipp E Scherer, Kari Alitalo, Donald M McDonald
Chylous pleural effusion (chylothorax) frequently accompanies lymphatic vessel malformations and other conditions with lymphatic defects. Although retrograde flow of chyle from the thoracic duct is considered a potential mechanism underlying chylothorax in patients and mouse models, the path chyle takes to reach the thoracic cavity is unclear. Herein, we use a novel transgenic mouse model, where doxycycline-induced overexpression of vascular endothelial growth factor (VEGF)-C was driven by the adipocyte-specific promoter adiponectin (ADN), to determine how chylothorax forms...
September 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28683030/testing-for-quality-and-safety-education-for-nurses-qsen-reflections-from-using-qsen-as-a-framework-for-rn-orientation
#19
David H James, Patricia A Patrician, Rebecca S Miltner
The use of the Quality and Safety Education for Nurses (QSEN) competencies for nursing professional development is in its infancy. QSEN content was incorporated into nursing orientation and tested knowledge gain for three QSEN competencies. Results showed an increase in patient safety knowledge. A difference was noted in knowledge between ADN and BSN nurses for evidence-based practice and quality improvement. The results indicate a need for stronger interventions to build practicing nurses' QSEN competencies...
July 2017: Journal for Nurses in Professional Development
https://www.readbyqxmd.com/read/28562401/using-a-standardized-patient-to-improve-collaboration-and-problem-solving-skills-with-cpap-usage-in-the-home
#20
Margaret G Williams, Joan Ruhs
A review of literature revealed a lack of research pertaining to nurses' or student nurses' knowledge of continuous positive airway pressure (CPAP) and the ability to troubleshoot CPAP malfunction. This study sought to answer the following questions: What are associate degree nursing (ADN) students' knowledge, interdisciplinary communication, and problem-solving skills regarding patients' home use of CPAP? Is there a change after participation in a simulation with a patient on CPAP in home setting? Twenty-one ADN students enrolled in small Midwest college participated...
June 2017: Home Healthcare Now
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