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Hepatitis B virus

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https://www.readbyqxmd.com/read/28240789/evaluation-of-hepatitis-b-reactivation-among-62-920-veterans-treated-with-oral-hepatitis-c-antivirals
#1
Pamela S Belperio, Troy A Shahoumian, Larry A Mole, Lisa I Backus
: Reactivation of hepatitis B virus (HBV) has been reported in hepatitis C virus (HCV) infected individuals receiving direct-acting antiviral (DAA) therapy. The overall risk among patients with current or prior HBV infection in the context of DAA treatment is unknown. The aim of this evaluation was to identify and characterize HBV reactivation among veterans treated with oral DAA therapy. This retrospective evaluation included 62,290 HCV-infected veterans completing oral DAA treatment...
February 27, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28239568/expression-of-hepatitis-b-virus-surface-antigens-induces-defective-gonad-phenotypes-in-caenorhabditis-elegans
#2
Yi-Yin Chen, Li-Wei Lee, Wei-Ning Hong, Szecheng J Lo
AIM: To test whether a simple animal, Caenorhabditis elegans (C. elegans), can be used as an alternative model to study the interaction between hepatitis B virus antigens (HBsAg) and host factors. METHODS: Three plasmids that were able to express the large, middle and small forms of HBsAgs (LHBsAg, MHBsAg, and SHBsAg, respectively) driven by a ubiquitous promoter (fib-1) and three that were able to express SHBsAg driven by different tissue-specific promoters were constructed and microinjected into worms...
February 12, 2017: World Journal of Virology
https://www.readbyqxmd.com/read/28239319/prevalence-of-hepatitis-b-hepatitis-c-and-human-immunodeficiency-viral-infections-in-patients-with-inflammatory-bowel-disease-in-north-india
#3
Parnita Harsh, Vipin Gupta, Saurabh Kedia, Sawan Bopanna, Sucharita Pilli, Surendernath, Govind Kumar Makharia, Vineet Ahuja
BACKGROUND/AIMS: Patients with inflammatory bowel disease (IBD) often require immunosuppressive therapy and blood transfusions and therefore are at a high risk of contracting infections due to hepatitis B (HBV) and hepatitis C (HCV) and human immunodeficiency virus (HIV). In the present study, we assessed the prevalence of these infections in patients with IBD. METHODS: This retrospective study included 908 consecutive patients with IBD (ulcerative colitis [UC], n=581; Crohn's disease [CD], n=327) who were receiving care at a tertiary care center...
January 2017: Intestinal Research
https://www.readbyqxmd.com/read/28237828/the-development-of-hepatocarcinoma-after-long-term-antivirus-treatment-of-chinese-patients-with-chronic-hepatitis-b-virus-infection-incidence-long-term-outcomes-and-predictive-factors
#4
Zhi-Qin Li, Chun-Ling Hu, Ping Yu, Xin-Yu Gu, Jia-Jia Zhang, Hua Li, Hong-Yu Zhang, Jun Lv, Yan-Min Liu, Qing-Lei Zeng, Jing-Ya Yan, Zu-Jiang Yu, Yi Zhang
BACKGROUND: Patients with chronic hepatitis B virus (HBV) infection are at high risk for progressing to decompensated cirrhosis and hepatocellular carcinoma (HCC). Although long-term treatment with nucleos(t)ide analogues (NAs) benefits patients with chronic hepatitis B (CHB), many develop HCC. Therefore, the clinical outcomes of patients CHB who undergo long-term treatment with NAs remain to be identified. The aim of this study therefore was to evaluate the risk and predictors of patients with CHB who develop hepatitis B-induced HCC...
February 22, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28237252/effect-of-ebola-virus-disease-on-maternal-and-child-health-services-in-guinea-a-retrospective-observational-cohort-study
#5
Alexandre Delamou, Alison M El Ayadi, Sidikiba Sidibe, Therese Delvaux, Bienvenu S Camara, Sah D Sandouno, Abdoul H Beavogui, Georges W Rutherford, Junko Okumura, Wei-Hong Zhang, Vincent De Brouwere
BACKGROUND: The 2014 west African epidemic of Ebola virus disease posed a major threat to the health systems of the countries affected. We sought to quantify the consequences of Ebola virus disease on maternal and child health services in the highly-affected Forest region of Guinea. METHODS: We did a retrospective, observational cohort study of women and children attending public health facilities for antenatal care, institutional delivery, and immunisation services in six of seven health districts in the Forest region (Beyla, Guéckédou, Kissidougou, Lola, Macenta, and N'Zérékoré)...
February 22, 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28236666/the-epsilon-motif-of-hepatitis-b-virus-rna-exhibits-a-potassium-dependent-ribonucleolytic-activity
#6
Dibyajnan Chakraborty, Sagarmoy Ghosh
Fourteen different classes of ribozymes are known that catalyze a range of diverse chemical reactions. We report here a novel potassium-dependent nucleolytic activity present in Hepatitis B Virus (HBV) RNA. A short RNA region (53 nt) with enzymatic properties released itself from the viral sequence by cis cleavages and could subsequently act in trans. The released region encompassed the epsilon motif present in the HBV RNA. The 3' end of the liberated fragment was within the non-canonical polyadenylation signal (UAUAAA) of the viral RNA while cleavages at about 53 nt upstream sites released the fragment...
February 25, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28236535/impaired-expression-and-function-of-tlr8-in-chronic-hbv-infection-and-its-association-with-treatment-responses-during-peg-ifn-%C3%AE-2a-antiviral-therapy
#7
Guangying Deng, Jun Ge, Chao Liu, Jinke Pang, Zuxiong Huang, Jie Peng, Jian Sun, Jinlin Hou, Xiaoyong Zhang
BACKGROUND AND AIM: Toll-like receptor 8 (TLR8) plays an important role in controlling chronic viral infections. However, the role of TLR8 in chronic hepatitis B virus (HBV) infection is poorly understood. In this study, we aimed to investigate the expression and function of TLR8 in peripheral blood mononuclear cells (PBMCs) of chronic hepatitis B (CHB) patients and its alteration during peg-IFN-α-2a therapy. METHODS: We evaluated TLR8 expression and antiviral function in vitro by real-time RT-PCR and flow cytometry analysis using fresh PBMCs obtained from CHB patients compared to healthy controls...
February 21, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28236405/formulation-of-dried-lignans-nanosuspension-with-high-redispersibility-to-enhance-stability-dissolution-and-oral-bioavailability
#8
Gang Shen, Ling Cheng, Li-Qiang Wang, Li-Hong Zhang, Bao-De Shen, Wei-Bo Liao, Juan-Juan Li, Juan Zheng, Rong Xu, Hai-Long Yuan
Herpetospermum caudigerum lignans (HTL), one of the potential drugs with anti-hepatitis B virus and hepatoprotective effects, has limited clinical applications because of poor aqueous solubility and low bioavailability. Both herpetrione (HPE) and herpetin (HPN) are the most abundant ingredients in HTL and exhibit weak acidity. The purpose of the present study was to produce dried preparations of HTL (composed of HPE and HPN) nanosuspensions (HTL-NS) with high redispersibility using lyophilization technology...
October 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28236308/prmt5-restricts-hepatitis-b-virus-replication-via-epigenetic-repression-of-cccdna-transcription-and-interference-with-pgrna-encapsidation
#9
Wen Zhang, Jieliang Chen, Min Wu, Xiaonan Zhang, Min Zhang, Lei Yue, Yaming Li, Jiangxia Liu, Baocun Li, Fang Shen, Yang Wang, Lu Bai, Ulrike Protzer, Massimo Levrero, Zhenghong Yuan
: Chronic hepatitis B virus (HBV) infection remains a major health problem worldwide. The covalently closed circular DNA (cccDNA) minichromosome, which serves as the template for the transcription of viral RNAs, plays a key role in viral persistence. While accumulating evidence suggests that cccDNA transcription is regulated by epigenetic machinery, particularly the acetylation of cccDNA-bound histone 3 (H3) and H4, the potential contributions of histone methylation and related host factors remain obscured...
February 25, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28236303/characterization-of-hepatitis-b-virus-hbv-pres-s-gene-mutations-in-blood-donors-with-occult-hbv-infection-in-the-baoji-area-of-north-china
#10
Hao Liao, Yan Liu, Jianhong Chen, Weiping Ding, Xiaodong Li, Zhihui Xu, Yuan Yang, Rongjuan Chen, Lanlan Si, Xiaoyuan Xu, Jianxun Guo, Dongping Xu
BACKGROUND: Occult hepatitis B virus (HBV) infection (OBI) in blood donors was investigated in the Baoji area of North China, and OBI-related viral mutations in donors were characterized. STUDY DESIGN AND METHODS: In total, 110,843 blood donor samples that were consecutively collected from December 2011 to March 2015 at the Baoji Blood Center were examined. Hepatitis B surface antigen-negative and HBV DNA-positive OBI samples were amplified for sequence analysis of OBI-related mutations in the HBV preS/S region...
February 24, 2017: Transfusion
https://www.readbyqxmd.com/read/28236070/widespread-geographical-disparities-in-chronic-hepatitis-b-virus-infection-in-algeria
#11
Aïcha Bensalem, Karima Selmani, Hihi Narjes, Nesrine Bencherifa, Mahdia Soltani, Fatma Mostefaoui, Cherif Kerioui, Pascal Pineau, Saadi Berkane, Nabil Debzi
Algeria is the largest country of Africa, with a population of 40 million inhabitants living in disparate environments from the Sahara to the large cities of the Mediterranean coast. The molecular epidemiology of hepatitis B virus (HBV) variants has been partially described, but variations in the seroprevalence of HBV surface antigen (HBsAg) throughout the Algerian territories are still poorly described. We analyzed demographic features of new cases of chronic infection collected in 41 administrative regions (covering 92% of the population) in 2013...
February 24, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28235985/-spontaneous-remission-of-hcv-infection-after-autologous-stem-cell-transplantation-in-a-58-year-old-man
#12
L Reinhardt, H Eiffert, G Wulf, P Ströbel, S C B Bremer, A Amanzada, V Ellenrieder, A Neesse
We report about a 58-year-old man with a chronic and treatment-naive hepatitis C virus (HCV) infection of genotype 1b, who had undergone autologous stem cell transplantation twice due to multiple myeloma. Subsequently, a high-level viremic reactivation of an occult hepatitis B virus (HBV) infection and also a reverse seroconversion was observed. Furthermore, a sustained spontaneous remission of HCV infection was seen. Antiviral therapy of HBV infection was initiated with tenofovir. Seven months after therapy initiation, the patient acquired an "anti-HBc-only" status...
February 24, 2017: Der Internist
https://www.readbyqxmd.com/read/28231679/-use-the-markov-decision-tree-model-to-optimize-vaccination-strategies-of-hepatitis-e-among-women-aged-15-to-49
#13
Z M Chen, S B Ji, X L Shi, Y Y Zhao, X F Zhang, H Jin
Objective: To evaluate the cost-utility of different hepatitis E vaccination strategies in women aged 15 to 49. Methods: The Markov-decision tree model was constructed to evaluate the cost-utility of three hepatitis E virus vaccination strategies. Parameters of the models were estimated on the basis of published studies and experience of experts. Both methods on sensitivity and threshold analysis were used to evaluate the uncertainties of the model. Results: Compared with non-vaccination group, strategy on post-screening vaccination with rate as 100%, could save 0...
February 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28231294/association-of-neutrophil-lymphocyte-ratio-and-t-lymphocytes-with-the-pathogenesis-and-progression-of-hbv-associated-primary-liver-cancer
#14
Xiaoli Liu, Lingling He, Junyan Han, Lijia Wang, Mengge Li, Yuyong Jiang, Xianbo Wang, Zhiyun Yang
BACKGROUND: The neutrophil-lymphocyte ratio (NLR) is a new prognostic predictor for patients with liver cancer. The association of NLR and T lymphocytes with the pathogenesis and progression of liver cancer is poorly understood. METHODS: Seventy-three patients with hepatitis B virus (HBV)-associated primary liver cancer (HBV-PLC), 50 patients with HBV-associated liver cirrhosis (HBV-LC) and 37 patients with chronic HBV infection (CHB) were prospectively enrolled from July 1, 2013 to February 28, 2014 in Beijing Ditan Hospital, Capital Medical University (Beijing, China)...
2017: PloS One
https://www.readbyqxmd.com/read/28230928/reactivation-of-hepatitis-b-in-patients-of-chronic-hepatitis-c-with-hepatitis-b-virus-infection-treated-with-direct-acting-antivirals
#15
Ming-Lun Yeh, Chung-Feng Huang, Meng-Hsuan Hsieh, Yu-Min Ko, Kuan-Yu Chen, Ta-Wei Liu, Yi-Hung Lin, Po-Cheng Liang, Ming-Yen Hsieh, Zu-Yau Lin, Shinn-Cherng Chen, Ching-I Huang, Jee-Fu Huang, Po-Lin Kuo, Chia-Yen Dai, Ming-Lung Yu, Wan-Long Chuang
BACKGROUND AND AIMS: Hepatitis B virus (HBV) may reactivate when treating chronic hepatitis C (CHC) with direct acting antivirals (DAA). We aim to investigate the risk of HBV reactivation during DAA therapy. METHODS: CHC patients receiving pan-oral DAA therapy from Dec. 2013 to Aug. 2016 were evaluated. Fifty-seven patients that had a past HBV infection (negative hepatitis B surface antigen (HBsAg)) and positive hepatitis B core antibody (Anti-HBc)) and 7 patients that had a current HBV infection (positive HBsAg) were enrolled...
February 23, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28230775/prec-and-c-regions-of-woodchuck-hepatitis-virus-facilitate-persistent-expression-of-surface-antigen-of-chimeric-whv-hbv-virus-in-the-hydrodynamic-injection-balb-c-mouse-model
#16
Weimin Wu, Yan Liu, Yong Lin, Danzhen Pan, Dongliang Yang, Mengji Lu, Yang Xu
In the hydrodynamic injection (HI) BALB/c mouse model with the overlength viral genome, we have found that woodchuck hepatitis virus (WHV) could persist for a prolonged period of time (up to 45 weeks), while hepatitis B virus (HBV) was mostly cleared at week four. In this study, we constructed a series of chimeric genomes based on HBV and WHV, in which the individual sequences of a 1.3-fold overlength HBV genome in pBS-HBV1.3 were replaced by their counterparts from WHV. After HI with the WHV-HBV chimeric constructs in BALB/c mice, serum viral antigen, viral DNA (vDNA), and intrahepatic viral antigen expression were analyzed to evaluate the persistence of the chimeric genomes...
February 21, 2017: Viruses
https://www.readbyqxmd.com/read/28230455/outcomes-of-pharmacy-led-hepatitis-c-direct-acting-antiviral-utilization-management-at-a-veterans-affairs-medical-center
#17
Sendra Yang, Rachel B Britt, Mohamed G Hashem, Jamie N Brown
BACKGROUND: The Veterans Affairs Health (VA) Administration has reported hepatitis C virus (HCV) infection rates among veterans to be twice that of the general U.S population. New HCV direct-acting antiviral (DAA) treatment options offer superior sustained virologic response (SVR) rates, improved side-effect profiles, and shortened treatment courses; yet, these new HCV DAAs are expensive, and utilization management strategies are needed to optimize use and improve clinical outcomes. A VA medical center uses pharmacist-led HCV DAA utilization management strategies that includes clinical guidance, optimizing operational flow, budget tracking and forecasting, and patient outcomes tracking...
March 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28230038/association-between-hepatitis-b-virus-hepatitis-c-virus-infection-and-primary-hepatocellular-carcinoma-risk-a-meta-analysis-based-on-chinese-population
#18
Libo Li, Xiaolin Lan
OBJECTIVE: To assess the relationship between hepatitis B virus (HBV), hepatitis C virus (HCV), and HBV/HCV double infection and hepatocellular carcinoma risk in Chinese population. MATERIALS AND METHODS: The databases of PubMed and CNKI were electronic searched by reviewers according to the searching words of HBV, HCV, and hepatocellular carcinoma. The related case-control studies or cohort studies were included. The association between virus infection and hepatocellular carcinoma risk was demonstrated by odds ratio (OR) and 95% confidence interval (95% CI)...
December 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28229987/kinetics-of-hepatitis-b-surface-antigen-level-in-chronic-hepatitis-b-patients-who-achieved-hepatitis-b-surface-antigen-loss-during-pegylated-interferon-alpha-2a-treatment
#19
Ming-Hui Li, Lu Zhang, Xiao-Jing Qu, Yao Lu, Ge Shen, Shu-Ling Wu, Min Chang, Ru-Yu Liu, Lei-Ping Hu, Zhen-Zhen Li, Wen-Hao Hua, Shu-Jing Song, Yao Xie
BACKGROUND: Hepatitis B surface antigen (HBsAg) loss/seroconversion is considered to be the ideal endpoint of antiviral therapy and the ultimate treatment goal in chronic hepatitis B (CHB). This study aimed to assess the patterns of HBsAg kinetics in CHB patients who achieved HBsAg loss during the treatment of pegylated interferon (PEG-IFN) α-2a. METHODS: A total of 150 patients were enrolled, composing of 83 hepatitis B envelope antigen (HBeAg)-positive and 67 HBeAg-negative patients...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28228589/capsid-phosphorylation-state-and-hepadnavirus-virion-secretion
#20
Xiaojun Ning, Suresh H Basagoudanavar, Kuancheng Liu, Laurie Luckenbaugh, Duoqian Wei, Chunyan Wang, Bo Wei, Yingren Zhao, Taotao Yan, William Delaney, Jianming Hu
The C-terminal domain (CTD) of hepadnavirus core protein is involved in multiple steps of viral replication. In particular, CTD is initially phosphorylated at multiple sites to facilitate viral RNA packaging into immature nucleocapsids (NCs) and the early stage of viral DNA synthesis. For the avian hepadnavirus, the duck hepatitis B virus (DHBV), CTD is dephosphorylated subsequently to facilitate the late stage of viral DNA synthesis and to stabilize NCs containing mature viral DNA. The role of CTD phosphorylation in virion secretion, if any, has remained unclear...
February 22, 2017: Journal of Virology
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