Sridhar Chaganti, Shanna Maycock, Graham McIlroy, Aimee E Jackson, Rebecca Bishop, Sarah Johnson, Edward Kanfer, Shireen Kassam, Kate Cwynarski, David J Wrench, Arvind Arumainathan, Christopher P Fox, Rod J Johnson, Pamela McKay, Shankara Paneesha, Clare Rowntree, Constantine Balotis, Graham P Collins, Andrew J Davies, Josh Wright, Sarah Burns, Arian Dominic John Laurence, Keith Wheatley, Tobias Menne
Post-transplant lymphoproliferative disorder (PTLD) is a rare complication of solid organ transplantation, and cytotoxic chemotherapy is associated with treatment-related morbidity and mortality. Current treatment takes a sequential, risk-stratified approach, patients with low-risk disease following initial immunotherapy can avoid escalation to immunochemotherapy. TIDaL is a prospective, single-arm phase 2 trial investigating the activity and tolerability of ibrutinib combined with risk-stratified therapy for first-line treatment of PTLD...
April 21, 2024: Blood