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https://www.readbyqxmd.com/read/29224182/stable-and-rigid-dtpa-like-paramagnetic-tags-suitable-for-in-vitro-and-in-situ-protein-nmr-analysis
#1
Jia-Liang Chen, Yu Zhao, Yan-Jun Gong, Bin-Bin Pan, Xiao Wang, Xun-Cheng Su
Organic synthesis of a ligand with high binding affinities for paramagnetic lanthanide ions is an effective way of generating paramagnetic effects on proteins. These paramagnetic effects manifested in high-resolution NMR spectroscopy are valuable dynamic and structural restraints of proteins and protein-ligand complexes. A paramagnetic tag generally contains a metal chelating moiety and a reactive group for protein modification. Herein we report two new DTPA-like tags, 4PS-PyDTTA and 4PS-6M-PyDTTA that can be site-specifically attached to a protein with a stable thioether bond...
December 9, 2017: Journal of Biomolecular NMR
https://www.readbyqxmd.com/read/29224042/association-between-continuous-positive-airway-pressure-and-serum-aminotransferases-in-patients-with-obstructive-sleep-apnea
#2
Li-Da Chen, Liang-Ji Zhang, Xue-Jun Lin, Jia-Chao Qi, Hao Li, Zhi Wu, Qiao-Zhen Xu, Ya-Ping Huang, Li Lin
INTRODUCTION: Obstructive sleep apnea (OSA) has been suggested to be a potential contributing factor for nonalcoholic fatty liver disease (NAFLD). Studies on the association between continuous positive airway pressure (CPAP) and NAFLD in OSA patients are limited and controversial. OBJECTIVES: The aim of this study was to assess the relationship between OSA and NAFLD and the effect of CPAP therapy on serum aminotransferase levels in OSA patients. METHODS: A total of 160 consecutive patients who underwent standard polysomnography were enrolled...
December 9, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29224024/association-of-the-tg-hdl-c-and-non-hdl-c-hdl-c-ratios-with-chronic-kidney-disease-in-an-adult-chinese-population
#3
Jia Wen, Yiyin Chen, Yun Huang, Yao Lu, Xing Liu, Honghao Zhou, Hong Yuan
BACKGROUND/AIMS: Evidence indicates a role for dyslipidemia in the development of chronic kidney disease (CKD). However, the association of lipid abnormalities and their ratios with kidney disease using the new CKD Epidemiology Collaboration (CKD-EPI) equation is not well understood. METHODS: This cross-sectional study included 48,054 adult subjects. CKD was defined as an estimated glomerular filtration rate <60 ml/min/1.73 m2 or dipstick-positive proteinuria...
December 8, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29224002/the-protective-effects-of-%C3%AE-opioid-receptor-stimulation-in-hypoxic-pulmonary-hypertension-involve-inhibition-of-autophagy-through-the-ampk-mtor-pathway
#4
Yaguang Zhou, Yuanbo Wang, Xu Wang, Xin Tian, Shumiao Zhang, Fan Yang, Haitao Guo, Rong Fan, Na Feng, Min Jia, Xiaoming Gu, Yuemin Wang, Juan Li, Jianming Pei
BACKGROUND/AIMS: In a previous study, we showed that κ-opioid receptor stimulation with the selective agonist U50,488H ameliorated hypoxic pulmonary hypertension (HPH). However, the roles that pulmonary arterial smooth muscle cell (PASMC) proliferation, apoptosis, and autophagy play in κ-opioid receptor-mediated protection against HPH are still unknown. The goal of the present study was to investigate the role of autophagy in U50,488H-induced HPH protection and the underlying mechanisms...
December 8, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29223957/prognostic-utility-of-morning-blood-pressure-surge-for-20-year-all-cause-and-cardiovascular-mortalities-results-of-a-community-based-study
#5
Hao-Min Cheng, Chung-Li Wu, Shih-Hsien Sung, Jia-Chun Lee, Kazuomi Kario, Chern-En Chiang, Chi-Jung Huang, Pai-Feng Hsu, Shao-Yuan Chuang, Edward G Lakatta, Frank C P Yin, Pesus Chou, Chen-Huan Chen
BACKGROUND: Morning blood pressure (BP) surge (MS), defined by the MS amplitude, is an independent prognostic factor of cardiovascular outcomes in some, but not all, populations. METHOD AND RESULTS: We enrolled 2020 participants (1029 men; aged 30-79 years) with 24-hour ambulatory BP data. During a median 19.7-year follow-up, 607 deaths (182 by cardiovascular causes) were confirmed from the National Death Registry. The amplitude of sleep-trough MS (STMS) was derived from the difference between morning systolic BP (SBP) and lowest nighttime SBP...
December 9, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29223764/hypoxia-induced-and-hif1%C3%AE-vegf-mediated-tight-junction-dysfunction-in-choriocarcinoma-cells-implications-for-preeclampsia
#6
Yuan Zhang, Hai-Jun Zhao, Xin-Ru Xia, Fei-Yang Diao, Xiang Ma, Jing Wang, Li Gao, Jie Liu, Chao Gao, Yu-Gui Cui, Jia-Yin Liu
INTRODUCTION: Accumulated data indicate that placental hypoxia is implicated in the pathogenesis of preeclampsia (PE). Tight junction (TJ) is important structure that sustains normal placental barrier function, its dysregulation under hypoxia has been observed. This study was designed to explore hypoxia-induced TJ dysfunction in trophoblast cells and its possible involvement in PE pathophysiology. METHODS: Choriocarcinoma cells were grown in a monolayer and treated with cobalt chloride (CoCl2) to induce hypoxia...
December 6, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29223735/targeting-secreted-cytokine-bmp9-gates-the-attenuation-of-hepatic-fibrosis
#7
Peng Li, Yongyun Li, Liqi Zhu, Zhi Yang, Jie He, Lihua Wang, Qingfeng Shang, Hui Pan, Huixue Wang, Xiong Ma, Bin Li, Xianqun Fan, Shengfang Ge, Renbing Jia, He Zhang
Liver fibrosis is overly exuberant wound healing that leads to portal hypertension or liver cirrhosis. Recent studies have demonstrated the functions of bone morphogenetic protein 9 (BMP9) in liver fibrosis, and thus, targeting liver-specific BMP9 abnormalities will become an attractive approach for developing therapeutics to treat liver fibrosis. Here, we reveal that BMP9 serves as a valuable serum diagnostic indicator and efficient therapeutic target to attenuate liver fibrogenesis. Our analysis of biopsies from liver fibrotic patients revealed that higher BMP9 levels accompanied advanced stages of liver fibrosis...
December 6, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29223542/interval-exercise-training-increases-lif-expression-and-prevents-myocardial-infarction-induced-skeletal-muscle-atrophy-in-rats
#8
Dandan Jia, Mengxin Cai, Yue Xi, Shaojun Du, ZhenjunTian
AIMS: Myocardial infarction (MI) is commonly associated with body weight loss and skeletal muscle atrophy. Studies have shown that exercise training could give beneficial effects on skeletal muscle growth. Leukemia inhibitory factor (LIF) is a key regulator of muscle growth and regeneration. The aim of this study was to investigate the effects of interval exercise training (IET) on the expression of LIF and the MI-induced skeletal muscle atrophy. MAIN METHODS: Male Sprague-Dawley rats were used to establish the MI model by ligation of the left anterior descending coronary artery...
December 6, 2017: Life Sciences
https://www.readbyqxmd.com/read/29223455/recyclable-colorimetric-sensor-of-cr3-and-pb2-ions-simultaneously-using-a-zwitterionic-amino-acid-modified-gold-nanoparticles
#9
Fuming Sang, Xin Li, Zhizhou Zhang, Jia Liu, Guofu Chen
In this work, a rapid, simple and sensitive colorimetric sensor for simultaneous (or respective) detection of Cr3+ and Pb2+ using tyrosine functionalized gold nanoparticles (AuNPsTyr) has been developed. Tyrosine, a natural and zwitterionic amino acid, could be as a reducing and capping agent to synthesise AuNPs and allow for the simultaneous and selective detection of Cr3+ and Pb2+. Upon the addition of Cr3+ or Pb2+ (a combination of them), the color of AuNPsTyr solution changes from red to blue grey and the characteristic surface plasmon resonance (SPR) band is red-shifted to 580nm due to the aggregation of AuNPs...
November 27, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29223356/isolation-of-novel-microsatellite-markers-and-their-application-for-genetic-diversity-and-parentage-analyses-in-sika-deer
#10
Wanyun Yang, Junjun Zheng, Boyin Jia, Haijun Wei, Guiwu Wang, Fuhe Yang
Every part of the sika deer (Cervus nippon) body is valuable traditional Chinese medicine. And sika deer is the most important semi-domestic medicinal animal that is widely bred in Jilin province northeast of China. But few studies had been conducted to characterize the microsatellite markers derived from sika deer. We firstly used IlluminaHiSeq™2500 sequencing technology obtained 125Mbp genomic data of sika deer. Using microsatellite identification tool (MISA), 22,479 microsatellites were identified. From these data, 100 potential primers were selected for further polymorphic validation, finally, 76 primer pairs were successfully amplified and 29 primer pairs were found to be obvious polymorphic in 8 different individuals...
December 6, 2017: Gene
https://www.readbyqxmd.com/read/29223041/understanding-motivations-for-dietary-supplementation-during-pregnancy-a-focus-group-study
#11
Lenka Malek PhD, Wendy J Umberger PhD, Maria Makrides PhD, Carmel T Collins PhD, Shao Jia Zhou PhD
OBJECTIVE: to increase understanding of psychosocial factors (behavioural, normative and control beliefs) motivating vitamin and mineral supplement use during pregnancy. DESIGN: ten focus group discussions and two in-depth interviews were conducted using a script comprising questions based on study objectives. All discussions were recorded, transcribed verbatim and analysed using a framework approach. SETTING: South Australia, Australia. SUBJECTS: 40 women aged 21-45 years who were either pregnant or<12 months postpartum...
November 26, 2017: Midwifery
https://www.readbyqxmd.com/read/29222499/crystal-structure-of-an-rna-cleaving-dnazyme
#12
Hehua Liu, Xiang Yu, Yiqing Chen, Jing Zhang, Baixing Wu, Lina Zheng, Phensinee Haruehanroengra, Rui Wang, Suhua Li, Jinzhong Lin, Jixi Li, Jia Sheng, Zhen Huang, Jinbiao Ma, Jianhua Gan
In addition to storage of genetic information, DNA can also catalyze various reactions. RNA-cleaving DNAzymes are the catalytic DNAs discovered the earliest, and they can cleave RNAs in a sequence-specific manner. Owing to their great potential in medical therapeutics, virus control, and gene silencing for disease treatments, RNA-cleaving DNAzymes have been extensively studied; however, the mechanistic understandings of their substrate recognition and catalysis remain elusive. Here, we report three catalytic form 8-17 DNAzyme crystal structures...
December 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/29222114/blood-vitronectin-is-a-major-activator-of-lif-and-il-6-in-the-brain-through-integrin-fak-and-upar-signaling
#13
M P Keasey, C Jia, L F Pimentel, R S Sante, C Lovins, T Hagg
We defined how blood-derived vitronectin (VTN) rapidly and potently activates leukemia inhibitory factor (LIF) and pro-inflammatory interleukin 6 (IL-6) in vitro and after vascular injury in the brain. VTN (not fibrinogen, fibronectin, laminin-111, collagen-I) robustly increased LIF and IL-6 within 4 hr in C6-astroglioma cells, while VTN-/- mouse plasma was less effective than wildtype. LIF and IL-6 were induced by intracerebral injection of rhVTN in mice, but less by intracerebral hemorrhage in VTN-/- than wildtype littermates...
December 8, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/29222012/macrophage-immunomodulatory-activity-of-the-polysaccharide-isolated-from-collybia-radicata-mushroom
#14
Yufeng Wang, Youqiu Tian, Jiangjuan Shao, Xu Shu, Jinxia Jia, Xiaojie Ren, Yue Guan
Polysaccharides from Collybia radicata mushroom (CRP) possess many functions, such as antiviral, anti-aging and hypolipidemic activities. However, little is known about their immunomodulatory activity. To address this issue, we did a thorough research into their immune effects on murine macrophages. The results showed that the 14942Da polysaccharide not only obviously improved the proliferation and phagocytosis of macrophages, but also induced the secretion of nitric oxide (NO), inducible nitric oxide synthase (iNOS) and cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin factors (IL-1β, IL-6 and IL-10)...
December 6, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29222010/a-novel-nr2f2-loss-of-function-mutation-predisposes-to-congenital-heart-defect
#15
Xiao-Hui Qiao, Qian Wang, Juan Wang, Xing-Yuan Liu, Ying-Jia Xu, Ri-Tai Huang, Song Xue, Yan-Jie Li, Min Zhang, Xin-Kai Qu, Ruo-Gu Li, Xing-Biao Qiu, Yi-Qing Yang
Congenital heart defect (CHD) is the most common type of birth defect in humans and a leading cause of infant morbidity and mortality. Previous studies have demonstrated that genetic defects play a pivotal role in the pathogenesis of CHD. However, the genetic basis of CHD remains poorly understood due to substantial genetic heterogeneity. In this study, the coding exons and splicing boundaries of the NR2F2 gene, which encodes a pleiotropic transcription factor required for normal cardiovascular development, were sequenced in 168 unrelated patients with CHD, and a novel mutation (c...
December 5, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29221988/modulations-of-keap1-nrf2-signaling-axis-by-tiia-ameliorated-the-oxidative-stress-induced-myocardial-apoptosis
#16
Shi-Hai Yan, Ning-Wei Zhao, Zhi-Rong Geng, Jia-Yin Shen, Fu-Ming Liu, Dong Yan, Jie Zhou, Chao Nie, Cheng-Cai Huang, Zhu-Yuan Fang
Mounting evidence has strongly implicated oxidative stress in the development of cardiac dysfunction, and myocardial apoptosis contributes to the pathogenesis of heart failure. Quantitative cardiac proteomics data revealed that pressure load by TAC resulted in a significant decline in mitochondrial metabolic activity, where TIIA (Tanshinone IIA sulfonate) treatment reversed it in vivo, which might be mediated by Nrf2. In NRVMs, TIIA treatment ameliorated H2O2-induced caspase-3/9 activations through the suppression of p38 and mTOR signaling pathways, where caspase-mediated cleavage of YY1 and PARP resulted in the defects in mitochondrial biogenesis and DNA repair, and this event finally led to cardiomyocyte apoptosis...
December 5, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29221981/chest-computed-tomography-image-for-accurately-predicting-the-optimal-insertion-depth-of-left-sided-double-lumen-tube
#17
Zhuo Liu, Li Zhao, Qianqian Jia, Xiaochun Yang, Shu Juan Liang, Wensheng He
OBJECTIVE: The main objective of this study was to assess the feasibility and accuracy of measuring the distance between the vocal cord and carina using chest computer tomography (CT) as a guide for the intubation of a left-sided double-lumen tube (LDLT). DESIGN: Single-center, prospective, randomized study. SETTING: Local hospital in China. PARTICIPANTS: Sixty adult patients undergoing elective thoracic surgery requiring an LDLT for one lung ventilation were enrolled in this study...
September 20, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29221793/pannexin-1-channel-dysfunction-in-the-medial-prefrontal-cortex-mediates-depressive-like-behaviors-induced-by-chronic-social-defeat-stress-and-administration-of-mefloquine-in-mice
#18
Ming Ni, Jin-Gang He, Hai-Yun Zhou, Xiao-Jia Lu, Yuan-Lang Hu, Li Mao, Fang Wang, Jian-Guo Chen, Zhuang-Li Hu
Mefloquine (MFQ) is widely used for the treatment of malaria clinically. Apart from antimalarial effect, psychiatric side effects such as depression and anxiety of MFQ have been reported. Interestingly, MFQ is also known as a broad-spectrum pannexin-1 (Panx1) inhibitor. Panx1 is a new gap junction channel expressed in the brain which mediates efflux of adenosine triphosphate (ATP). Although exogenous ATP has been known to produce a potential antidepressant-like effect, little is known about the role of Panx1 in pathophysiology of depression, especially the depression induced by administration of MFQ...
December 5, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29221441/time-varying-serum-gradient-of-hepatitis-b-surface-antigen-predicts-risk-of-relapses-after-off-na-therapy
#19
Nai-Hsuan Chien, Yen-Tsung Huang, Chun-Ying Wu, Chi-Yang Chang, Ming-Shiang Wu, Jia-Horng Kao, Lein-Ray Mo, Chi-Ming Tai, Chih-Wen Lin, Tzeng-Huey Yang, Jaw-Town Lin, Yao-Chun Hsu
BACKGROUND: The serum gradient of hepatitis B surface antigen (HBsAg) varies over time after cessation of nucleos(t)ide analog (NA) treatment in patients with chronic hepatitis B (CHB). The association between the time-varying HBsAg serum gradient and risk of relapse has not been elucidated. METHODS: This multicenter cohort study prospectively enrolled CHB patients who discontinued 3 year-NA treatment. Eligible patients were serologically negative for HBeAg and viral DNA at NA cessation...
December 8, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29221306/systemic-tunnel-dissection-of-mediastinal-lymph-nodes-without-clamping-via-uniportal-video-assisted-thoracoscopic-surgery
#20
Jia-Tao Zhang, Song Dong, Xue-Ning Yang, Yi-Long Wu, Wen-Zhao Zhong
Here we introduce a manual tunnel approach to remove the mediastinal lymph nodes and highlight the conception of non-clamping during dissection. We describe two cases of pulmonary malignancy performing a strategic lobectomy and systemic dissection of mediastinal lymph nodes via single port. The technique of tunnel dissection without clamping ensure to satisfy the requirement of oncology and clinical criteria. By efficiently specifying surgery procedure and improving dissection thoroughness, our approach should be implemented...
September 2017: Journal of Thoracic Disease
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