keyword
https://read.qxmd.com/read/38728755/development-and-validation-of-a-novel-nomogram-for-predicting-long-term-rebleeding-risk-among-patients-with-hemorrhagic-moyamoya-disease-a-10-year-multicenter-retrospective-cohort-study
#1
JOURNAL ARTICLE
Jing-Jie Li, Xiao-Peng Wang, Xiang-Yang Bao, Qian-Nan Wang, Zi-Qing Kong, Qing-Bao Guo, Jia-Qi Liu, Gan Gao, Min-Jie Wang, Si-Meng Liu, He-Guan Fu, Huai-Yu Tong, Lian Duan
OBJECTIVE: The aim of this study was to develop and validate a predictive nomogram model for long-term rebleeding events in patients with hemorrhagic moyamoya disease (HMMD). METHODS: In total, 554 patients with HMMD from the Fifth Medical Center of the Chinese PLA General Hospital (5-PLAGH cohort) were included and randomly divided into training (390 patients) and internal validation (164 patients) sets. An independent cohort from the First Medical Center and Eighth Medical Center of Chinese PLA General Hospital (the 1-PLAGH and 8-PLAGH cohort) was used for external validation (133 patients)...
May 10, 2024: Journal of Neurosurgery
https://read.qxmd.com/read/38728735/emergence-of-long-range-angular-correlations-in-low-multiplicity-proton-proton-collisions
#2
JOURNAL ARTICLE
S Acharya, D Adamová, G Aglieri Rinella, L Aglietta, M Agnello, N Agrawal, Z Ahammed, S Ahmad, S U Ahn, I Ahuja, A Akindinov, M Al-Turany, D Aleksandrov, B Alessandro, H M Alfanda, R Alfaro Molina, B Ali, A Alici, N Alizadehvandchali, A Alkin, J Alme, G Alocco, T Alt, A R Altamura, I Altsybeev, J R Alvarado, M N Anaam, C Andrei, N Andreou, A Andronic, E Andronov, V Anguelov, F Antinori, P Antonioli, N Apadula, L Aphecetche, H Appelshäuser, C Arata, S Arcelli, M Aresti, R Arnaldi, J G M C A Arneiro, I C Arsene, M Arslandok, A Augustinus, R Averbeck, M D Azmi, H Baba, A Badalà, J Bae, Y W Baek, X Bai, R Bailhache, Y Bailung, R Bala, A Balbino, A Baldisseri, B Balis, D Banerjee, Z Banoo, F Barile, L Barioglio, M Barlou, B Barman, G G Barnaföldi, L S Barnby, E Barreau, V Barret, L Barreto, C Bartels, K Barth, E Bartsch, N Bastid, S Basu, G Batigne, D Battistini, B Batyunya, D Bauri, J L Bazo Alba, I G Bearden, C Beattie, P Becht, D Behera, I Belikov, A D C Bell Hechavarria, F Bellini, R Bellwied, S Belokurova, L G E Beltran, Y A V Beltran, G Bencedi, S Beole, Y Berdnikov, A Berdnikova, L Bergmann, M G Besoiu, L Betev, P P Bhaduri, A Bhasin, M A Bhat, B Bhattacharjee, L Bianchi, N Bianchi, J Bielčík, J Bielčíková, A P Bigot, A Bilandzic, G Biro, S Biswas, N Bize, J T Blair, D Blau, M B Blidaru, N Bluhme, C Blume, G Boca, F Bock, T Bodova, S Boi, J Bok, L Boldizsár, M Bombara, P M Bond, G Bonomi, H Borel, A Borissov, A G Borquez Carcamo, H Bossi, E Botta, Y E M Bouziani, L Bratrud, P Braun-Munzinger, M Bregant, M Broz, G E Bruno, M D Buckland, D Budnikov, H Buesching, S Bufalino, P Buhler, N Burmasov, Z Buthelezi, A Bylinkin, S A Bysiak, J C Cabanillas Noris, M Cai, H Caines, A Caliva, E Calvo Villar, J M M Camacho, P Camerini, F D M Canedo, S L Cantway, M Carabas, A A Carballo, F Carnesecchi, R Caron, L A D Carvalho, J Castillo Castellanos, F Catalano, S Cattaruzzi, C Ceballos Sanchez, R Cerri, I Chakaberia, P Chakraborty, S Chandra, S Chapeland, M Chartier, S Chattopadhyay, S Chattopadhyay, T Cheng, C Cheshkov, V Chibante Barroso, D D Chinellato, E S Chizzali, J Cho, S Cho, P Chochula, D Choudhury, P Christakoglou, C H Christensen, P Christiansen, T Chujo, M Ciacco, C Cicalo, M R Ciupek, G Clai, F Colamaria, J S Colburn, D Colella, M Colocci, M Concas, G Conesa Balbastre, Z Conesa Del Valle, G Contin, J G Contreras, M L Coquet, P Cortese, M R Cosentino, F Costa, S Costanza, C Cot, J Crkovská, P Crochet, R Cruz-Torres, P Cui, A Dainese, M C Danisch, A Danu, P Das, P Das, S Das, A R Dash, S Dash, A De Caro, G de Cataldo, J de Cuveland, A De Falco, D De Gruttola, N De Marco, C De Martin, S De Pasquale, R Deb, R Del Grande, L Dello Stritto, W Deng, P Dhankher, D Di Bari, A Di Mauro, B Diab, R A Diaz, T Dietel, Y Ding, J Ditzel, R Divià, D U Dixit, Ø Djuvsland, U Dmitrieva, A Dobrin, B Dönigus, J M Dubinski, A Dubla, S Dudi, P Dupieux, M Durkac, N Dzalaiova, T M Eder, R J Ehlers, F Eisenhut, R Ejima, D Elia, B Erazmus, F Ercolessi, B Espagnon, G Eulisse, D Evans, S Evdokimov, L Fabbietti, M Faggin, J Faivre, F Fan, W Fan, A Fantoni, M Fasel, A Feliciello, G Feofilov, A Fernández Téllez, L Ferrandi, M B Ferrer, A Ferrero, C Ferrero, A Ferretti, V J G Feuillard, V Filova, D Finogeev, F M Fionda, E Flatland, F Flor, A N Flores, S Foertsch, I Fokin, S Fokin, E Fragiacomo, E Frajna, U Fuchs, N Funicello, C Furget, A Furs, T Fusayasu, J J Gaardhøje, M Gagliardi, A M Gago, T Gahlaut, C D Galvan, D R Gangadharan, P Ganoti, C Garabatos, T García Chávez, E Garcia-Solis, C Gargiulo, P Gasik, A Gautam, M B Gay Ducati, M Germain, A Ghimouz, C Ghosh, M Giacalone, G Gioachin, P Giubellino, P Giubilato, A M C Glaenzer, P Glässel, E Glimos, D J Q Goh, V Gonzalez, P Gordeev, M Gorgon, K Goswami, S Gotovac, V Grabski, L K Graczykowski, E Grecka, A Grelli, C Grigoras, V Grigoriev, S Grigoryan, F Grosa, J F Grosse-Oetringhaus, R Grosso, D Grund, N A Grunwald, G G Guardiano, R Guernane, M Guilbaud, K Gulbrandsen, T Gündem, T Gunji, W Guo, A Gupta, R Gupta, R Gupta, K Gwizdziel, L Gyulai, C Hadjidakis, F U Haider, S Haidlova, M Haldar, H Hamagaki, A Hamdi, Y Han, B G Hanley, R Hannigan, J Hansen, J W Harris, A Harton, M V Hartung, H Hassan, D Hatzifotiadou, P Hauer, L B Havener, E Hellbär, H Helstrup, M Hemmer, T Herman, G Herrera Corral, F Herrmann, S Herrmann, K F Hetland, B Heybeck, H Hillemanns, B Hippolyte, F W Hoffmann, B Hofman, G H Hong, M Horst, A Horzyk, Y Hou, P Hristov, P Huhn, L M Huhta, T J Humanic, A Hutson, D Hutter, M C Hwang, R Ilkaev, H Ilyas, M Inaba, G M Innocenti, M Ippolitov, A Isakov, T Isidori, M S Islam, M Ivanov, M Ivanov, V Ivanov, K E Iversen, M Jablonski, B Jacak, N Jacazio, P M Jacobs, S Jadlovska, J Jadlovsky, S Jaelani, C Jahnke, M J Jakubowska, M A Janik, T Janson, S Ji, S Jia, A A P Jimenez, F Jonas, D M Jones, J M Jowett, J Jung, M Jung, A Junique, A Jusko, M J Kabus, J Kaewjai, P Kalinak, A S Kalteyer, A Kalweit, D Karatovic, O Karavichev, T Karavicheva, P Karczmarczyk, E Karpechev, U Kebschull, R Keidel, D L D Keijdener, M Keil, B Ketzer, S S Khade, A M Khan, S Khan, A Khanzadeev, Y Kharlov, A Khatun, A Khuntia, Z Khuranova, B Kileng, B Kim, C Kim, D J Kim, E J Kim, J Kim, J Kim, J Kim, M Kim, S Kim, T Kim, K Kimura, S Kirsch, I Kisel, S Kiselev, A Kisiel, J P Kitowski, J L Klay, J Klein, S Klein, C Klein-Bösing, M Kleiner, T Klemenz, A Kluge, C Kobdaj, T Kollegger, A Kondratyev, N Kondratyeva, J Konig, S A Konigstorfer, P J Konopka, G Kornakov, M Korwieser, S D Koryciak, A Kotliarov, N Kovacic, V Kovalenko, M Kowalski, V Kozhuharov, I Králik, A Kravčáková, L Krcal, M Krivda, F Krizek, K Krizkova Gajdosova, M Kroesen, M Krüger, D M Krupova, E Kryshen, V Kučera, C Kuhn, P G Kuijer, T Kumaoka, D Kumar, L Kumar, N Kumar, S Kumar, S Kundu, P Kurashvili, A Kurepin, A B Kurepin, A Kuryakin, S Kushpil, V Kuskov, M Kutyla, M J Kweon, Y Kwon, S L La Pointe, P La Rocca, A Lakrathok, M Lamanna, A R Landou, R Langoy, P Larionov, E Laudi, L Lautner, R Lavicka, R Lea, H Lee, I Legrand, G Legras, J Lehrbach, T M Lelek, R C Lemmon, I León Monzón, M M Lesch, E D Lesser, P Lévai, X Li, B E Liang-Gilman, J Lien, R Lietava, I Likmeta, B Lim, S H Lim, V Lindenstruth, A Lindner, C Lippmann, D H Liu, J Liu, G S S Liveraro, I M Lofnes, C Loizides, S Lokos, J Lömker, P Loncar, X Lopez, E López Torres, P Lu, F V Lugo, J R Luhder, M Lunardon, G Luparello, Y G Ma, M Mager, A Maire, E M Majerz, M V Makariev, M Malaev, G Malfattore, N M Malik, Q W Malik, S K Malik, L Malinina, D Mallick, N Mallick, G Mandaglio, S K Mandal, V Manko, F Manso, V Manzari, Y Mao, R W Marcjan, G V Margagliotti, A Margotti, A Marín, C Markert, P Martinengo, M I Martínez, G Martínez García, M P P Martins, S Masciocchi, M Masera, A Masoni, L Massacrier, O Massen, A Mastroserio, O Matonoha, S Mattiazzo, A Matyja, C Mayer, A L Mazuecos, F Mazzaschi, M Mazzilli, J E Mdhluli, Y Melikyan, A Menchaca-Rocha, J E M Mendez, E Meninno, A S Menon, M Meres, Y Miake, L Micheletti, D L Mihaylov, K Mikhaylov, D Miśkowiec, A Modak, B Mohanty, M Mohisin Khan, M A Molander, S Monira, C Mordasini, D A Moreira De Godoy, I Morozov, A Morsch, T Mrnjavac, V Muccifora, S Muhuri, J D Mulligan, A Mulliri, M G Munhoz, R H Munzer, H Murakami, S Murray, L Musa, J Musinsky, J W Myrcha, B Naik, A I Nambrath, B K Nandi, R Nania, E Nappi, A F Nassirpour, A Nath, C Nattrass, M N Naydenov, A Neagu, A Negru, E Nekrasova, L Nellen, R Nepeivoda, S Nese, G Neskovic, N Nicassio, B S Nielsen, E G Nielsen, S Nikolaev, S Nikulin, V Nikulin, F Noferini, S Noh, P Nomokonov, J Norman, N Novitzky, P Nowakowski, A Nyanin, J Nystrand, S Oh, A Ohlson, V A Okorokov, J Oleniacz, A Onnerstad, C Oppedisano, A Ortiz Velasquez, J Otwinowski, M Oya, K Oyama, Y Pachmayer, S Padhan, D Pagano, G Paić, S Paisano-Guzmán, A Palasciano, S Panebianco, H Park, H Park, J Park, J E Parkkila, Y Patley, B Paul, M M D M Paulino, H Pei, T Peitzmann, X Peng, M Pennisi, S Perciballi, D Peresunko, G M Perez, Y Pestov, V Petrov, M Petrovici, R P Pezzi, S Piano, M Pikna, P Pillot, O Pinazza, L Pinsky, C Pinto, S Pisano, M Płoskoń, M Planinic, F Pliquett, M G Poghosyan, B Polichtchouk, S Politano, N Poljak, A Pop, S Porteboeuf-Houssais, V Pozdniakov, I Y Pozos, K K Pradhan, S K Prasad, S Prasad, R Preghenella, F Prino, C A Pruneau, I Pshenichnov, M Puccio, S Pucillo, Z Pugelova, S Qiu, L Quaglia, S Ragoni, A Rai, A Rakotozafindrabe, L Ramello, F Rami, T A Rancien, M Rasa, S S Räsänen, R Rath, M P Rauch, I Ravasenga, K F Read, C Reckziegel, A R Redelbach, K Redlich, C A Reetz, H D Regules-Medel, A Rehman, F Reidt, H A Reme-Ness, Z Rescakova, K Reygers, A Riabov, V Riabov, R Ricci, M Richter, A A Riedel, W Riegler, A G Riffero, C Ristea, M V Rodriguez, M Rodríguez Cahuantzi, S A Rodríguez Ramírez, K Røed, R Rogalev, E Rogochaya, T S Rogoschinski, D Rohr, D Röhrich, P F Rojas, S Rojas Torres, P S Rokita, G Romanenko, F Ronchetti, A Rosano, E D Rosas, K Roslon, A Rossi, A Roy, S Roy, N Rubini, D Ruggiano, R Rui, P G Russek, R Russo, A Rustamov, E Ryabinkin, Y Ryabov, A Rybicki, H Rytkonen, J Ryu, W Rzesa, O A M Saarimaki, S Sadhu, S Sadovsky, J Saetre, K Šafařík, P Saha, S K Saha, S Saha, B Sahoo, R Sahoo, S Sahoo, D Sahu, P K Sahu, J Saini, K Sajdakova, S Sakai, M P Salvan, S Sambyal, D Samitz, I Sanna, T B Saramela, D Sarkar, P Sarma, V Sarritzu, V M Sarti, M H P Sas, S Sawan, E Scapparone, J Schambach, H S Scheid, C Schiaua, R Schicker, F Schlepper, A Schmah, C Schmidt, H R Schmidt, M O Schmidt, M Schmidt, N V Schmidt, A R Schmier, R Schotter, A Schröter, J Schukraft, K Schweda, G Scioli, E Scomparin, J E Seger, Y Sekiguchi, D Sekihata, M Selina, I Selyuzhenkov, S Senyukov, J J Seo, D Serebryakov, L Serkin, L Šerkšnytė, A Sevcenco, T J Shaba, A Shabetai, R Shahoyan, A Shangaraev, B Sharma, D Sharma, H Sharma, M Sharma, S Sharma, S Sharma, U Sharma, A Shatat, O Sheibani, K Shigaki, M Shimomura, J Shin, S Shirinkin, Q Shou, Y Sibiriak, S Siddhanta, T Siemiarczuk, T F Silva, D Silvermyr, T Simantathammakul, R Simeonov, B Singh, B Singh, K Singh, R Singh, R Singh, R Singh, S Singh, V K Singh, V Singhal, T Sinha, B Sitar, M Sitta, T B Skaali, G Skorodumovs, M Slupecki, N Smirnov, R J M Snellings, E H Solheim, J Song, C Sonnabend, J M Sonneveld, F Soramel, A B Soto-Hernandez, R Spijkers, I Sputowska, J Staa, J Stachel, I Stan, P J Steffanic, S F Stiefelmaier, D Stocco, I Storehaug, P Stratmann, S Strazzi, A Sturniolo, C P Stylianidis, A A P Suaide, C Suire, M Sukhanov, M Suljic, R Sultanov, V Sumberia, S Sumowidagdo, I Szarka, M Szymkowski, S F Taghavi, G Taillepied, J Takahashi, G J Tambave, S Tang, Z Tang, J D Tapia Takaki, N Tapus, L A Tarasovicova, M G Tarzila, G F Tassielli, A Tauro, A Tavira García, G Tejeda Muñoz, A Telesca, L Terlizzi, C Terrevoli, S Thakur, D Thomas, A Tikhonov, N Tiltmann, A R Timmins, M Tkacik, T Tkacik, A Toia, R Tokumoto, K Tomohiro, N Topilskaya, M Toppi, T Tork, P V Torres, V V Torres, A G Torres Ramos, A Trifiró, A S Triolo, S Tripathy, T Tripathy, S Trogolo, V Trubnikov, W H Trzaska, T P Trzcinski, A Tumkin, R Turrisi, T S Tveter, K Ullaland, B Ulukutlu, A Uras, M Urioni, G L Usai, M Vala, N Valle, L V R van Doremalen, M van Leeuwen, C A van Veen, R J G van Weelden, P Vande Vyvre, D Varga, Z Varga, M Vasileiou, A Vasiliev, O Vázquez Doce, O Vazquez Rueda, V Vechernin, E Vercellin, S Vergara Limón, R Verma, L Vermunt, R Vértesi, M Verweij, L Vickovic, Z Vilakazi, O Villalobos Baillie, A Villani, A Vinogradov, T Virgili, M M O Virta, V Vislavicius, A Vodopyanov, B Volkel, M A Völkl, S A Voloshin, G Volpe, B von Haller, I Vorobyev, N Vozniuk, J Vrláková, J Wan, C Wang, D Wang, Y Wang, Y Wang, A Wegrzynek, F T Weiglhofer, S C Wenzel, J P Wessels, J Wiechula, J Wikne, G Wilk, J Wilkinson, G A Willems, B Windelband, M Winn, J R Wright, W Wu, Y Wu, R Xu, A Yadav, A K Yadav, Y Yamaguchi, S Yang, S Yano, E R Yeats, Z Yin, I-K Yoo, J H Yoon, H Yu, S Yuan, A Yuncu, V Zaccolo, C Zampolli, F Zanone, N Zardoshti, A Zarochentsev, P Závada, N Zaviyalov, M Zhalov, B Zhang, C Zhang, L Zhang, S Zhang, X Zhang, Y Zhang, Z Zhang, M Zhao, V Zherebchevskii, Y Zhi, C Zhong, D Zhou, Y Zhou, J Zhu, Y Zhu, S C Zugravel, N Zurlo
This Letter presents the measurement of near-side associated per-trigger yields, denoted ridge yields, from the analysis of angular correlations of charged hadrons in proton-proton collisions at sqrt[s]=13  TeV. Long-range ridge yields are extracted for pairs of charged particles with a pseudorapidity difference of 1.4<|Δη|<1.8 and a transverse momentum of 1<p_{T}<2  GeV/c, as a function of the charged-particle multiplicity measured at midrapidity. This Letter extends the measurements of the ridge yield to the low multiplicity region, where in hadronic collisions it is typically conjectured that a strongly interacting medium is unlikely to be formed...
April 26, 2024: Physical Review Letters
https://read.qxmd.com/read/38728560/early-experience-with-a-novel-treatment-for-meni%C3%A3-re-s-disease-a-long-acting-dexamethasone-formulation-for-precise-delivery-to-the-round-window-membrane
#3
JOURNAL ARTICLE
Jafri Kuthubutheen, Jeffrey D Sharon, Benson T Jung, Ali R Sepahdari, Jia Hui Ng, Signe Erickson, Hugo Peris, Eugene De Juan, Charles J Limb
OBJECTIVE: To investigate the safety and feasibility of precise delivery of a long-acting gel formulation containing 6% dexamethasone (SPT-2101) to the round window membrane for the treatment of Menière's disease. STUDY DESIGN: Prospective, unblinded, cohort study. SETTING: Tertiary care neurotology clinic. PATIENTS: Adults 18 to 85 years with a diagnosis of unilateral definite Menière's disease per Barany society criteria...
June 1, 2024: Otology & Neurotology
https://read.qxmd.com/read/38728416/the-effects-of-changes-in-cigarette-menthol-content-on-acute-nicotine-pharmacology-and-smoking-topography
#4
JOURNAL ARTICLE
Hristina Dimova, Megan J Schroeder, Wallace B Pickworth, Jia Wang, Olusola Oniyide, Lauren C Viray, Carson Smith, Bartosz Koszowski, Kia J Jackson
INTRODUCTION: Menthol influences the appeal and addictiveness of cigarette smoking, however the data regarding menthol's effects on nicotine pharmacokinetics (PK) and smoking topography are inconsistent. This study investigated the impact of different cigarette menthol levels on nicotine pharmacology and smoking topography in current menthol smokers. AIMS AND METHODS: The study was a double-blind, randomized, four-period, crossover study to investigate the effects of smoking cigarettes with varying menthol content (0, 3, 6, and 12 mg menthol) on nicotine PK, smoking topography, and subjective effects in current menthol smokers...
May 10, 2024: Nicotine & Tobacco Research
https://read.qxmd.com/read/38728411/development-of-1-month-sustained-release-microspheres-containing-liraglutide-for-type-2-diabetes-treatment
#5
JOURNAL ARTICLE
Zejing Gao, Yi Wei, Jia Ge, Jingxuan Liu, Ying Qin, Fangling Gong, Guanghui Ma
Liraglutide has been extensively applied in the treatment of type 2 diabetes mellitus (T2DM), but its 11-15 h half-life resulted in daily administration, which led to poor patient compliance. This study aimed to solve this problem by developing liraglutide-loaded microspheres with a 1 month sustained release prepared by the W1 /O/W2 method combined with the premix membrane emulsification technique to improve therapeutic efficacy. Remarkably, we found that the amphiphilic properties of liraglutide successfully reduced the oil-water interfacial tension, resulting in a stable primary emulsion and decreasing the level of drug leakage into the external water phase...
May 10, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38728364/cetuximab-plus-folfoxiri-versus-cetuximab-plus-folfox-as-conversion-regimen-in-ras-braf-wild-type-patients-with-initially-unresectable-colorectal-liver-metastases-trice-trial-a-randomized-controlled-trial
#6
RANDOMIZED CONTROLLED TRIAL
De-Shen Wang, Chao Ren, Shan-Shan Li, William Pat Fong, Xiao-Jun Wu, Jian Xiao, Bin-Kui Li, Yun Zheng, Pei-Rong Ding, Gong Chen, Miao-Zhen Qiu, Zhi-Qiang Wang, Feng-Hua Wang, Hui-Yan Luo, Feng Wang, Xiao-Zhong Wang, Ling-Yun Wang, De-Jin Xie, Tao Chen, Li-Ren Li, Zhen-Hai Lu, Xiao-Hui Zhai, Tian-Shu Liu, Ying Yuan, Jia-Qi Chen, Qiong Tan, Zhi-Zhong Pan, De-Sen Wan, Rong Zhang, Yun-Fei Yuan, Rui-Hua Xu, Yu-Hong Li
BACKGROUND: It remains unclear whether intensification of the chemotherapy backbone in tandem with an anti-EGFR can confer superior clinical outcomes in a cohort of RAS/BRAF wild-type colorectal cancer (CRC) patients with initially unresectable colorectal liver metastases (CRLM). To that end, we sought to comparatively evaluate the efficacy and safety of cetuximab plus FOLFOXIRI (triplet arm) versus cetuximab plus FOLFOX (doublet arm) as a conversion regimen (i.e., unresectable to resectable) in CRC patients with unresectable CRLM...
May 2024: PLoS Medicine
https://read.qxmd.com/read/38727886/economic-evaluation-of-nirmatrelvir-ritonavir-among-adults-against-hospitalization-during-the-omicron-dominated-period-in-malaysia-a-real-world-evidence-perspective
#7
JOURNAL ARTICLE
Ee Vien Low, Hoon Shien Teh, Nicholas Yee Liang Hing, Suresh Kumar Chidambaram, Mohan Dass Pathmanathan, Wee Ric Kim, Wei Jia Lee, Zhi Wei Teh, Maheshwara Rao Appannan, Shahanizan Mohd Zin, Faizah Muhamad Zin, Samha Bashirah Mohamed Amin, Mastura Ismail, Azah Abdul Samad, Kalaiarasu M Peariasamy
BACKGROUND AND OBJECTIVES: Nirmatrelvir/ritonavir was administered orally to manage mild to moderate symptoms of COVID-19 in adult patients. The objectives of this study were to (i) evaluate the cost-effectiveness of prescribing nirmatrelvir/ritonavir within 5 days of a COVID-19 illness in order to avert hospitalization within a 30-day period in the Malaysia setting; (ii) determine how variations in pricing and hospitalization rates will affect the cost-effectiveness of nirmatrelvir/ritonavir...
May 10, 2024: Drugs—Real World Outcomes
https://read.qxmd.com/read/38727837/camrelizumab-plus-famitinib-in-previously-chemo-immunotherapy-treated-patients-with-advanced-nsclc-results-from-an-open-label-multicenter-phase-2-basket-study
#8
MULTICENTER STUDY
Shengxiang Ren, Anwen Xiong, Jia Yu, Xicheng Wang, Baohui Han, Yueyin Pan, Jun Zhao, Yufeng Cheng, Sheng Hu, Tianshu Liu, Yalun Li, Ying Cheng, Jifeng Feng, Shanyong Yi, Shanzhi Gu, Shegan Gao, Yongzhong Luo, Ying Liu, Caigang Liu, Huijie Duan, Shuni Wang, Xinfeng Yang, Jia Fan, Caicun Zhou
BACKGROUND: The combination of immune checkpoint inhibitors and antiangiogenic agents has been effective in treating multiple cancers. This was further explored in an open-label, multicenter phase 2 basket study (NCT04346381), which evaluated the antitumor activity and safety of camrelizumab (an anti-PD-1 antibody) plus famitinib (a receptor tyrosine kinase inhibitor) in patients with advanced solid tumors. We herein report the findings from the cohort of advanced NSCLC patients who progressed after treatment with platinum-doublet chemotherapy and immunotherapy...
May 10, 2024: Cancer Immunology, Immunotherapy: CII
https://read.qxmd.com/read/38727819/an-investigation-of-the-acute-effects-of-aerobic-exercise-on-executive-function-and-cortical-excitability-in-adolescents-with-attention-deficit-hyperactivity-disorder-adhd
#9
JOURNAL ARTICLE
Hsiao-I Kuo, Jia-Ling Sun, Michael Nitsche, Jung-Chi Chang
Previous studies have shown that aerobic exercise has beneficial effects on executive function in adolescents with attention-deficit hyperactivity disorder (ADHD). The underlying mechanisms could be partially due to aerobic exercise-induced cortical excitability modulation. The aim of this study was to explore the effects of acute aerobic exercise on executive functions and cortical excitability and the association between these phenomena in adolescents with ADHD. The study was conducted using a complete crossover design...
May 10, 2024: European Child & Adolescent Psychiatry
https://read.qxmd.com/read/38727707/diagnostic-value-of-ovarian-ultrasound-index-combined-with-amh-and-lh-fsh-in-the-success-rate-of-ivf-assisted-pregnancy
#10
JOURNAL ARTICLE
Wencheng Wang, Zhu Jia, Ning Zhang
No abstract text is available yet for this article.
May 9, 2024: Minerva Medica
https://read.qxmd.com/read/38727547/crosstalk-between-brassinosteroids-and-other-phytohormones-during-plant-development-and-stress-adaption
#11
JOURNAL ARTICLE
Feimei Guo, Minghui Lv, Jingjie Zhang, Jia Li
Brassinosteroids (BRs) are a group of polyhydroxylated phytosterols that play essential roles in regulating plant growth and development as well as stress adaptation. It is worth noting that BRs do not function alone, but rather they crosstalk with other endogenous signaling molecules, including the phytohormones auxin, cytokinins (CKs), gibberellins (GAs), abscisic acid (ABA), ethylene (ET), jasmonates (JAs), salicylic acid (SA), and strigolactones (SLs), forming elaborate signaling networks to modulate plant growth and development...
May 10, 2024: Plant & Cell Physiology
https://read.qxmd.com/read/38727518/cerebral-autoregulation-a-reliable-predictor-of-prognosis-in-patients-receiving-intravenous-thrombolysis
#12
JOURNAL ARTICLE
Zhen-Ni Guo, Yang Qu, Zi-Duo Shen, Jia Liu, Zhong-Xiu Wang, Ying-Ying Sun, Ke-Jia Zhang, Junlei Chang, Xiang-Kun Si, Hang Jin, Xin Sun, Yi Yang
AIMS: To investigate the characteristics of dynamic cerebral autoregulation (dCA) after intravenous thrombolysis (IVT) and assess the relationship between dCA and prognosis. METHODS: Patients with unilateral acute ischemic stroke receiving IVT were prospectively enrolled; those who did not were selected as controls. All patients underwent dCA measurements, by quantifying the phase difference (PD) and gain, at 1-3 and 7-10 days after stroke onset. Simultaneously, two dCA-based nomogram models were established to verify the predictive value of dCA for patients with mild-to-moderate stroke...
May 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38727511/global-burden-of-liver-cirrhosis-1990-2019-and-20-years-forecast-results-from-the-global-burden-of-disease-study-2019
#13
JOURNAL ARTICLE
Yikai Wang, Muqi Wang, Chenrui Liu, Miao Hao, Wenjun Wang, Yaping Li, Juanjuan Shi, Xiaoli Jia, Xin Zhang, Shuangsuo Dang
BACKGROUND: Cirrhosis is a disease that imposes a heavy burden worldwide, but its incidence varies widely by region. Therefore, we analysed data on the incidence and mortality of cirrhosis in 204 countries and territories from 1990-2019 and projected the disease development from 2019-2039. METHODS: Data on the incidence and mortality of liver cirrhosis from 1990 to 2019 were acquired from the public Global Burden of Disease (GBD) study. In addition, the average annual percentage change (AAPC) and estimated annual percentage change (EAPC) of the age-standardized rate (ASR) of cirrhosis in different regions were calculated...
December 2024: Annals of Medicine
https://read.qxmd.com/read/38727381/adjoint-algorithm-design-of-selective-mode-reflecting-metastructure-for-bal-applications
#14
JOURNAL ARTICLE
Zean Li, Xunyu Zhang, Cheng Qiu, Yingshuai Xu, Zhipeng Zhou, Ziyuan Wei, Yiman Qiao, Yongyi Chen, Yubing Wang, Lei Liang, Yuxin Lei, Yue Song, Peng Jia, Yugang Zeng, Li Qin, Yongqiang Ning, Lijun Wang
Broad-area lasers (BALs) have found applications in a variety of crucial fields on account of their high output power and high energy transfer efficiency. However, they suffer from poor spatial beam quality due to multi-mode behavior along the waveguide transverse direction. In this paper, we propose a novel metasurface waveguide structure acting as a transverse mode selective back-reflector for BALs. In order to effectively inverse design such a structure, a digital adjoint algorithm is introduced to adapt the considerably large design area and the high degree of freedom...
May 1, 2024: Nanomaterials
https://read.qxmd.com/read/38727340/size-effects-of-copper-oxide-nanoparticles-on-boosting-soybean-growth-via-differentially-modulating-nitrogen-assimilation
#15
JOURNAL ARTICLE
Yaozu Guo, Hao Li, Yi Hao, Heping Shang, Weili Jia, Anqi Liang, Xinxin Xu, Chunyang Li, Chuanxin Ma
Nanoscale agrochemicals have been widely used in sustainable agriculture and may potentially affect the nitrogen fixation process in legume crops. The present study investigated the size-effects of copper oxide nanoparticles (CuO NPs) on nitrogen assimilation in soybean ( G. max (L.) Merrill) plants, which were treated with different sizes (20 and 50 nm) of CuO NPs at low use doses (1 and 10 mg/kg) for 21 days under greenhouse conditions. The results showed that 50 nm CuO NPs significantly increased the fresh biomass more than 20 nm CuO NPs achieved at 10 mg/kg...
April 25, 2024: Nanomaterials
https://read.qxmd.com/read/38727336/improvement-of-thermal-stability-and-photoelectric-performance-of-cs-2-pbi-2-cl-2-cspbi-2-5-br-0-5-perovskite-solar-cells-by-triple-layer-inorganic-hole-transport-materials
#16
JOURNAL ARTICLE
Yu Liu, Bicui Li, Jia Xu, Jianxi Yao
Conventional hole transport layer (HTL) Spiro-OMeTAD requires the addition of hygroscopic dopants due to its low conductivity and hole mobility, resulting in a high preparation cost and poor device stability. Cuprous thiocyanate (CuSCN) is a cost-effective alternative with a suitable energy structure and high hole mobility. However, CuSCN-based perovskite solar cells (PSCs) are affected by environmental factors, and the solvents of an HTL can potentially corrode the perovskite layer. In this study, a Co3 O4 /CuSCN/Co3 O4 sandwich structure was proposed as an HTL for inorganic Cs2 PbI2 Cl2 /CsPbI2...
April 24, 2024: Nanomaterials
https://read.qxmd.com/read/38727160/barley-protein-lfbep-c1-from-lactiplantibacillus-plantarum-dy-1-fermented-barley-extracts-by-inhibiting-lipid-accumulation-in-a-caenorhabditis-elegans-model
#17
JOURNAL ARTICLE
Jia Yan Zhang, Meng Ting Liu, Yu Hao Liu, Huan Deng, Juan Bai, Jian Hua Xie, Xiang Xiao
OBJECTIVE: This study aimed to investigate the lipid-lowering activity of LFBEP-C1 in high glucose-fed Caenorhabditis elegans (C. elegans) . METHODS: In this study, the fermented barley protein LFBEP-C1 was prepared and tested for its potential anti-obesity effects on C. elegans . The worms were fed Escherichia coli OP50 ( E. coli OP50), glucose, and different concentrations of LFBEP-C1. Body size, lifespan, movement, triglyceride content, and gene expression were analyzed...
April 20, 2024: Biomedical and Environmental Sciences: BES
https://read.qxmd.com/read/38727133/major-changes-in-prevalence-and-genotypes-of-rotavirus-diarrhea-in-beijing-china-after-rv5-rotavirus-vaccine-introduction
#18
JOURNAL ARTICLE
Yi Tian, Lingyu Shen, Weihong Li, Hanqiu Yan, Jiamei Fu, Baiwei Liu, Yu Wang, Lei Jia, Gang Li, Luodan Suo, Daitao Zhang, Zhiyong Gao, Quanyi Wang
To analyze the epidemiological characteristics of group A rotavirus (RVA) diarrhea in Beijing between 2019 and 2022 and evaluate the effectiveness of the RV5 vaccine. Stool specimens were collected from patients with acute diarrhea, and RVA was detected and genotyped. The whole genome of RVA was sequenced by fragment amplification and Sanger sequencing. Phylogenetic trees were constructed using Bayesian and maximum likelihood methods. Descriptive epidemiological methods were used to analyze the characteristics of RVA diarrhea...
May 2024: Journal of Medical Virology
https://read.qxmd.com/read/38727077/a-dual-cascade-activatable-near-infrared-fluorescent-probe-for-precise-intraoperative-imaging-of-tumor
#19
JOURNAL ARTICLE
Yanbin Feng, Haohao Yan, Xiaocheng Mou, Zuo Yang, Chaoqiang Qiao, Qian Jia, Ruili Zhang, Zhongliang Wang
Accurate intraoperative tumor delineation is critical to achieving successful surgical outcomes. However, conventional techniques typically suffer from poor specificity and low sensitivity and are time-consuming, which greatly affects intraoperative decision-making. Here, we report a cascade activatable near-infrared fluorescent (NIRF) probe IR780SS@CaP that can sequentially respond to tumor acidity and elevated glutathione levels for accurate intraoperative tumor localization. Compared with nonactivatable and single-factor activatable probes, IR780SS@CaP with a cascade strategy can minimize nonspecific activation and false positive signals in a complicated biological environment, affording a superior tumor-to-normal tissue ratio to facilitate the delineation of abdominal metastases...
May 10, 2024: Nano Letters
https://read.qxmd.com/read/38727018/tetrathiafulvalene-carboxylate-based-anode-material-for-high-performance-sodium-ion-batteries
#20
JOURNAL ARTICLE
Yuansheng Luo, Kangkang Jia, Xiaoxue Li, Jingwei Zhang, Guimei Huang, Cheng Zhong, Linna Zhu, Fei Wu
Organic electrode materials are promising to be applied in sodium ion batteries (SIBs) due to their low cost and easily modified molecular structures. Nevertheless, low conductivity and high solubility in electrolytes still limit the development of organic electrodes. In this work, a carboxylate small molecule (BDTTS) based on tetrathiafulvalene is developed as anode material for SIBs. BDTTS has a large rigid π-conjugated planar structure, which may reduce solubility in the electrolyte, meanwhile facilitating charge transporting...
May 10, 2024: ChemSusChem
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