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Xue-Liang Zuo, Juan Cai, Zhi-Qiang Chen, Yao Zhang, Lin-Hu Liang, Jun-Feng Wang, Jin-Guo Wang, Jian Wu, Jia-Ding Mao
PURPOSE: This meta-analysis aims to assess the prognostic value of long non-coding RNA ZEB1-AS1 in human solid tumors. METHODS: We searched the available databases up to January 2018. Pooled hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs) were used to examine the prognostic impact of ZEB1-AS1 on patient survival. RESULTS: Eight eligible studies with a total of 586 patients were enrolled. A significant association was observed between ZEB1-AS1 overexpression and poor overall survival (OS; HR = 2...
June 12, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Jing Liu, Jia-Xin Shen, Hua-Tao Wu, Xiao-Li Li, Xiao-Fen Wen, Cai-Wen Du, Guo-Jun Zhang
PURPOSE: Extracellular matrix (ECM) is an important component of tumor microenvironment and plays critical roles in cancer development and metastasis, in which collagen is the major structural protein. Collagen type I alpha 1 (COL1A1) is reportedly associated with the development of several human diseases. However, the functions and mechanisms of cellular expression of COL1A1 in breast cancer remain unknown. The purpose of this study is to investigate the cellular expression of COL1A1 in breast cancer cells and patients, and its role in the development and metastasis of breast cancer...
May 2018: Discovery Medicine
Yong Meng Sua, Jia-Yang Chen, Yu-Ping Huang
We report a wideband optical parametric amplification (OPA) over 14 THz covering telecom S, C, and L bands with observed maximum parametric gain of 38.3 dB. The OPA is realized through cascaded second-harmonic generation and difference-frequency generation (cSHG-DFG) in a 2 cm periodically poled LiNbO3 (PPLN) waveguide. With tailored cross section geometry, the waveguide is optimally mode matched for efficient cascaded nonlinear wave mixing. We also identify and study the effect of competing nonlinear processes in this cSHG-DFG configuration...
June 15, 2018: Optics Letters
Qiwei Wang, Lishuang Feng, Hui Li, Xiao Wang, Yongze Jia, Danni Liu
An enhanced differential detection technique (EDDT) is proposed to suppress common-mode signal and improve detection accuracy of the resonator integrated optic gyro (RIOG). Reciprocity of the RIOG based on a transmissive resonator is effectively promoted by proposing a novel structure, which has the benefit of suppressing the reciprocal error. Theoretical analysis shows the differential-mode output of the EDDT, which is in proportion to gyro angular rotation, can be amplified without the limitation of the RIOG's common-mode signal...
June 15, 2018: Optics Letters
Zhangyong Xia, Mingliang Gu, Xiaodong Jia, Xiaoting Wang, Chunxia Wu, Jiangwen Guo, Liyong Zhang, Yifeng Du, Jiyue Wang
Atherosclerosis (AS) is a multifactorial disease. Exploration of DNA methylation in regulating gene transcription in a cell type- and stage-specific manner will shed light on understanding the biological processes associated with plaque stability. We identified 174 up-regulated genes with hypo-methylation in the promoter, and 86 down-regulated genes with hyper-methylation in the promoter, in AS vs. healthy controls. Among them, high expression of signaling lymphocytic activation molecule 7 (SLAM7) was examined in carotid plaque vs...
June 13, 2018: Aging
Bao-Cheng Xie, Shi-Chun Chen, Jia-Huan Wu, Qing-Hui Wang, Chen-Hui Zhou, Dao-Hua Xu
No abstract text is available yet for this article.
June 14, 2018: Journal of Sports Medicine and Physical Fitness
Wen-Qiong Xue, Yong-Qiao He, Xiao-Yu Liao, Fang-Fang Li, Ya-Fei Xu, Feng-Hua Xu, Xi-Zhao Li, Qi-Sheng Feng, Li-Zhen Chen, Su-Mei Cao, Qing Liu, Yi-Xin Zeng, Wei-Hua Jia
The link of nasopharyngeal carcinoma (NPC) with Epstein-Barr virus (EBV) has been established for decades. Although an abnormal high level of EBV sero-antibody spectrum and cell-free circulating EBV DNA loads were exhibited in NPC patients, oral EBV DNA loads, which are primarily responsible for the EBV transmission, has not been previously studied in NPC patients. We conducted an epidemiological study to measure the oral EBV loads, viral components, and the relationship with the serum antibody titers in a large case-control population (968 cases and 1656 controls) and a family-based population (91 cases and 165 unaffected family members)...
June 14, 2018: Cancer Medicine
Jiping Sun, Jing Lv, Wenjing Zhang, Lili Li, Jia Lv, Yingzhou Geng, Aiping Yin
This in vitro study was performed to identify the role of miR-124a in bone marrow stromal stem cells (BMSCs) therapy for H2 O2 -induced rat podocyte injury, and determine whether combination treatment with miR-124a could improve the protective effect of BMSCs. Cell viability of podocytes was detected by CCK-8 assay. Detection of ROS level, apoptotic rate, and autophagy rate was carried out using flow cytometry assays. Oxidative stress parameters were analyzed using the ELISA assays. MiR-124a and mRNA levels were determined using real-time PCR...
June 15, 2018: Journal of Cellular Biochemistry
Jia Song, Xiaochao Zhang, Qianyun Ge, Chaoyi Yuan, Liang Chu, Hui-Fang Liang, Zhibin Liao, Qiumeng Liu, Zhanguo Zhang, Bixiang Zhang
Chronic hepatitis B virus (HBV) infection remains the most common risk factor for hepatocellular carcinoma (HCC). High HBV surface antigen (HBsAg) levels are highly correlated with hepatocarcinogenesis and HBV-associated HCC development. However, the role and detailed mechanisms associated with HBsAg in HCC development remain elusive. In this study, we designed specific single guide RNAs (sgRNAs) targeting the open reading frames, preS1/preS2/S, of the HBV genome and established HBsAg knockout HCC cell lines using the CRISPR/Cas9 system...
June 15, 2018: Journal of Cellular Biochemistry
Casey Keat-Chuan Ng, Choo-Hou Goh, Jia-Chun Lin, Minn-Syenn Tan, Willie Bong, Chea-Soon Yong, Jun-Yao Chong, Peter Aun-Chuan Ooi, Wey-Lim Wong, Gideon Khoo
El Niño and Southern Oscillation (ENSO) is a natural forcing that affects global climate patterns, thereon influencing freshwater quality and security. In the advent of a strong El Niño warming event in 2016 which induced an extreme dry weather in Malaysia, water quality variation was investigated in Kampar River which supplies potable water to a population of 92,850. Sampling points were stratified into four ecohydrological units and 144 water samples were examined from October 2015 to March 2017. The Malaysian Water Quality Index (WQI) and some supplementary parameters were analysed in the context of reduced precipitation...
June 15, 2018: Environmental Monitoring and Assessment
Jian Zhang, Kui Shi, Hongfeng Jia
Total knee arthroplasty (TKA) is highly associated with post-operative pain. The present randomized trial aimed to explore the possible post-operative pain management by a different combination of analgesics or opioids (ketamine and bupivacaine) following TKA. A total of 84 patients were randomly divided into four groups. All subjects were anesthetized for TKA surgery and received post-operative pain management via intra-articular saline (control group; n=23), ketamine (2 mg/kg) infused with saline (ket group; n=21) bupivacaine (0...
June 2018: Experimental and Therapeutic Medicine
Yibing Zhang, Yuan Hu, Xiaodong Li, Xiaoru Shi, Feihong Xu, Hui Jia
The aim of the present study was to investigate the role of the limbal stem cells in corneal epithelial homeostasis in patients with peripheral corneal disease who received corneal transplantation surgery. This retrospective study enrolled 85 patients (85 eyes) with peripheral corneal lesion who underwent corneal transplantation at Department of Ophthalmology in First Hospital of Jilin University, Jilin, China. All patients during each follow-up period were examined for best corrected visual acuity, corneal reconstruction (assessed by slit-lamp biomicroscopy), anterior segment optical coherence tomography, and confocal microscopy...
June 2018: Experimental and Therapeutic Medicine
Xiu-Min Chen, Jia-Qi Wu, Qing-Chun Huang, Jian-Yong Zhang, Jian-Hong Pen, Zhi-Sheng Huang, Yong-Liang Chu, Xiao-Hong He, Mao-Jie Wang, Run-Yue Huang
Biqi capsule is a Traditional Chinese Medicine preparation for treating rheumatoid arthritis (RA), and clinical studies have indicatedthat its effect may be more beneficial than that of Western medicine. The present study aimed to estimate the efficacy and safety of Biqi capsule alone or combined with methotrexate (MTX) compared with MTX alone for treating RA by performing a meta-analysis of randomized controlled trials and controlled clinical trials. A systematic literature search of studies published until March 2017 was performed...
June 2018: Experimental and Therapeutic Medicine
Tong Shao, Wei Shi, Jia-Yu Zheng, Xiao-Xiao Xu, Ai-Fu Lin, Li-Xin Xiang, Jian-Zhong Shao
CD58 and CD2 have long been known as a pair of reciprocal adhesion molecules involved in the immune modulations of CD8+ T and NK-mediated cellular immunity in humans and several other mammals. However, the functional roles of CD58 and CD2 in CD4+ T-mediated adaptive humoral immunity remain poorly defined. Moreover, the current functional observations of CD58 and CD2 were mainly acquired from in vitro assays, and in vivo investigation is greatly limited due to the absence of a Cd58 homology in murine models...
2018: Frontiers in Immunology
Huantian Cui, Yuzi Cai, Li Wang, Beitian Jia, Junchen Li, Shuwu Zhao, Xiaoqian Chu, Jin Lin, Xiaoyu Zhang, Yuhong Bian, Pengwei Zhuang
Berberine (BBR), an alkaloid isolated from Rhizoma Coptidis, Cortex Phellode , and Berberis , has been widely used in the treatment of ulcerative colitis (UC). However, the mechanism of BBR on UC is unknown. In this study, we investigated the activities of T regulatory cell (Treg) and T helper 17 cell (Th17) in a dextran sulfate sodium (DSS)-induced UC mouse model after BBR administration. We also investigated the changes of gut microbiota composition using 16S rRNA analysis. We also examined whether BBR could regulate the Treg/Th17 balance by modifying gut microbiota...
2018: Frontiers in Pharmacology
Linling Li, Gan Huang, Qianqian Lin, Jia Liu, Shengli Zhang, Zhiguo Zhang
The level of pain perception is correlated with the magnitude of pain-evoked brain responses, such as laser-evoked potentials (LEP), across trials. The positive LEP-pain relationship lays the foundation for pain prediction based on single-trial LEP, but cross-individual pain prediction does not have a good performance because the LEP-pain relationship exhibits substantial cross-individual difference. In this study, we aim to explain the cross-individual difference in the LEP-pain relationship using inter-stimulus EEG (isEEG) features...
2018: Frontiers in Neuroscience
Yineng Han, Lingfei Jia, Yunfei Zheng, Weiran Li
Saliva, which contains biological information, is considered a valuable diagnostic tool for local and systemic diseases and conditions because, similar to blood, it contains important molecules like DNA, RNA, and proteins. Exosomes are cell-derived vesicles 30-100 nm in diameter with substantial biological functions, including intracellular communication and signalling. These vesicles, which are present in bodily fluids, including saliva, are released upon fusion of multivesicular bodies (MVBs) with the cellular plasma membrane...
2018: International Journal of Biological Sciences
Zhen Liu, Zongyang Lu, Guang Yang, Shisheng Huang, Guanglei Li, Songjie Feng, Yajing Liu, Jianan Li, Wenxia Yu, Yu Zhang, Jia Chen, Qiang Sun, Xingxu Huang
A recently developed adenine base editor (ABE) efficiently converts A to G and is potentially useful for clinical applications. However, its precision and efficiency in vivo remains to be addressed. Here we achieve A-to-G conversion in vivo at frequencies up to 100% by microinjection of ABE mRNA together with sgRNAs. We then generate mouse models harboring clinically relevant mutations at Ar and Hoxd13, which recapitulates respective clinical defects. Furthermore, we achieve both C-to-T and A-to-G base editing by using a combination of ABE and SaBE3, thus creating mouse model harboring multiple mutations...
June 14, 2018: Nature Communications
Ningbo Chen, Yudong Cai, Qiuming Chen, Ran Li, Kun Wang, Yongzhen Huang, Songmei Hu, Shisheng Huang, Hucai Zhang, Zhuqing Zheng, Weining Song, Zhijie Ma, Yun Ma, Ruihua Dang, Zijing Zhang, Lei Xu, Yutang Jia, Shanzhai Liu, Xiangpeng Yue, Weidong Deng, Xiaoming Zhang, Zhouyong Sun, Xianyong Lan, Jianlin Han, Hong Chen, Daniel G Bradley, Yu Jiang, Chuzhao Lei
Cattle domestication and the complex histories of East Asian cattle breeds warrant further investigation. Through analysing the genomes of 49 modern breeds and eight East Asian ancient samples, worldwide cattle are consistently classified into five continental groups based on Y-chromosome haplotypes and autosomal variants. We find that East Asian cattle populations are mainly composed of three distinct ancestries, including an earlier East Asian taurine ancestry that reached China at least ~3.9 kya, a later introduced Eurasian taurine ancestry, and a novel Chinese indicine ancestry that diverged from Indian indicine approximately 36...
June 14, 2018: Nature Communications
Chenguang Qiu, Fei Liu, Lin Xu, Bing Deng, Mengmeng Xiao, Jia Si, Li Lin, Zhiyong Zhang, Jian Wang, Hong Guo, Hailin Peng, Lian-Mao Peng
An efficient way to reduce the power is to lower the supply voltage VDD , but this voltage is restricted by the 60 millivolts per decade thermionic limit of subthreshold swing (SS) in field-effect transistors (FETs). We show that a graphene Dirac source (DS) with a much narrower electron density distribution around the Fermi level than that of conventional FETs can lower SS. A DS-FET with a carbon nanotube channel provided an average SS of 40 millivolt per decade over four decades of current at room temperature and high device current I60 of up to 40 microampere per micrometer at 60 millivolts per decade...
June 14, 2018: Science
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