keyword
MENU ▼
Read by QxMD icon Read
search

Anti-platelet

keyword
https://www.readbyqxmd.com/read/29660929/ecchymosis-a-novel-sign-in-patients-with-varicose-veins
#1
Ertan Yetkin, Mehmet Ileri, Johannes Waltenberger
BACKGROUND: In the absence of trauma, hematologic disease and anti-platelet use, no attention has been paid to elucidate the mechanism of ecchymosis. It has taken our attention that ecchymosis on lower limb might be a sign of varicose vein. Accordingly, we aimed to analyze and describe the frequency of leg symptoms and presence of ecchymosis in patients with varicose vein. MATERIALS AND METHODS: Four hundred and ninety four patients who had been diagnosed as having varicose vein or chronic venous insufficiency either by clinical examination or Doppler ultrasonography were included in the study...
2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29644269/blunt-traumatic-celiac-artery-avulsion-managed-with-celiac-artery-ligation-and-open-aorto-celiac-bypass
#2
Matthew D Kronick, Andrew R Doben, Marvin E Morris, Ronald I Gross, Amanda Kravetz, Jeffry T Nahmias
Traumatic celiac artery injuries are rare and highly lethal with reported mortality rates of 38-62%. The vast majority are caused by penetrating trauma with only 11 reported cases due to blunt trauma (Graham et al., 1978; Asensio et al., 2000, 2002). Only 3 of these cases were complete celiac artery avulsions. Management options described depend upon the type of injury and have included medical therapy with anti-platelet agents or anti-coagulants, endovascular stenting, and open ligation. We report a case of a survivor of complete celiac artery avulsion from blunt trauma managed by open bypass...
October 2017: Trauma Case Reports
https://www.readbyqxmd.com/read/29625513/trends-characteristics-and-clinical-outcomes-of-patients-undergoing-percutaneous-coronary-intervention-in-korea-between-2011-and-2015
#3
Seungbong Han, Gyung Min Park, Yong Giun Kim, Mahn Won Park, Sung Ho Her, Seung Whan Lee, Young Hak Kim
BACKGROUND AND OBJECTIVES: We sought to evaluate nationwide trends, characteristics, and clinical outcomes in patients undergoing percutaneous coronary intervention (PCI) in Korea. METHODS: From National Health Insurance claims data in Korea, 81,115 patients, who underwent PCI for the first episode of coronary artery disease between 2011 and 2015, were enrolled. Patients were categorized into angina (n=49,288) or acute myocardial infarction (AMI, n=31,887) groups and analyzed...
April 2018: Korean Circulation Journal
https://www.readbyqxmd.com/read/29620219/anthricin%C3%A2-induced-caspase%C3%A2-dependent-apoptosis-through-igf1r-pi3k-akt-pathway-inhibition-in-a549-human-non%C3%A2-small-lung-cancer-cells
#4
Bo-Ram Park, Seul Ah Lee, Sung Min Moon, Chun Sung Kim
Anthricin (deoxypodophyllotoxin) is a major lignan in Anthriscus sylvestris and possesses many bioactivities such as antiproliferative, antitumor, anti‑platelet aggregation, antiviral and anti‑inflammatory actions. However, the anticancer effects of anthricin on A549 human non‑small cell lung cancer cells and potential molecular mechanisms remain unknown. Therefore, we investigated the anticancer effect of anthricin and the underlying mechanism in A549 cells. Anthricin (10‑200 nM) inhibited the viability of A549 cells in a dose‑ and time‑dependent manner...
March 27, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29618452/short-communication-synthesis-of-drug-metal-complexes-and-their-influence-on-human-platelet-aggregation
#5
Mansoor Ahmed, Mohsin Ali, Seyed Abdulmajid Ayatollahi, Marjan Esfahanizadeh, Farzad Kobarfard, Ameer Hasan, Khalid Mohammed Khan, Syed Moazzam Haider
During the past few decades the emergence of inorganic medicinal chemistry has been developed novel therapeutic agents. Researcher's perseverance in this branch of chemistry has led them to explore further valuable chemical spaces by synthesizing metal complexes already known pharmacological agents for their potential use. However, it is in its early stage, this methodology has demonstrated metal complexes with better bioactivities than the parent ligand molecules. In this study, transition metal complexes of pyrazinamide (PZ), isoniazid (INH), fluconazole (FCZ), metformin (dimethylbiguanide, DMBG) and losartan potassium (LS-K) were selected to evaluate for their possible anti-platelets aggregation in the light of reports on divalent and trivalent cations like calcium, copper, manganese, magnesium, and cadmium may influence the process of thrombocytic activity and aggregation...
March 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29600631/-exploring-chinese-medicine-and-western-medicine-group-modules-in-acute-phase-of-ischemic-stroke-disease
#6
Wei Yang, Ming-Quan Li, Yang Li, Lei-Lei Sun, Yan-Ming Xie, Chong-Hui Guo, Yan Zhuang
Under the theoretical guidance of "combination of disease and syndrome, correspondence between syndrome and prescription, and dynamic space-time", 11 135 acute ischemic stroke patients were collected from hospital information system(HIS) of many 3A grade hospitals of traditional Chinese medicine. Complex network analysis was adopted to obtain the core syndrome elements in different periods of acute ischemic stroke patients, and it was found that the core syndrome elements were blood stasis syndrome, phlegm, endogenous wind, Yin deficiency, Qi deficiency, heat, hyperactivity of liver Yang, liver, and kidney of patients in hospital for the first day, and during 8-14 d in hospitalization, the core syndrome elements were blood stasis, phlegm, Yin deficiency, Qi deficiency, endogenous wind, hyperactivity of liver Yang, liver, and kidney...
February 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29595186/evaluation-of-the-patterns-of-non-adherence-to-anti-platelet-regimens-in-stented-patients-bleeding-score-for-predicting-the-long-term-out-of-hospital-bleeding-risk-in-chinese-patients-after-percutaneous-coronary-intervention
#7
Xue-Yan Zhao, Jian-Xin Li, Xiao-Fang Tang, Jing-Jing Xu, Ying Song, Lin Jiang, Jue Chen, Lei Song, Li-Jian Gao, Zhan Gao, Shu-Bin Qiao, Yue-Jin Yang, Run-Lin Gao, Bo Xu, Jin-Qing Yuan
Background: The Patterns of Non-Adherence to Anti-Platelet Regimens in Stented Patients (PARIS) bleeding score is a novel score for predicting the out-of-hospital bleeding risk after percutaneous coronary intervention (PCI). However, whether this score has the same value in non-European and American populations is unclear. This study aimed to assess the PARIS bleeding score's predictive value of bleeding in patients after PCI in the Chinese population. Methods: We performed a prospective, observational study of 10,724 patients who underwent PCI from January to December 2013, in Fuwai Hospital, China...
March 27, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29589775/role-of-cyp2c19-genotype-testing-in-clinical-use-of-clopidogrel-is-it-really-useful
#8
Irfan Zeb, Nassim Krim, Jonathan Bella
P2Y12 inhibitors, including clopidogrel have become an integral part of treatment for patients receiving coronary stent placement as a result of stable coronary artery disease or acute coronary syndromes (ACS) and also for medically managed ACS patients. Areas covered: Clopidogrel efficacy can be significantly modified by polymorphism of CYP2C19 genotype (more than 25 allelic variants) involved in its metabolism that can adversely affect its anti-platelet activity. As a result, a substantial number of patients (20-30%) with ACS show an inadequate response to clopidogrel despite a standardized dosing regimen...
March 28, 2018: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/29580525/assessment-of-effects-of-phenolic-fractions-from-leaves-and-petals-of-dandelion-in-selected-components-of-hemostasis
#9
Bernadetta Lis, Dariusz Jędrejek, Anna Stochmal, Beata Olas
Aerial parts and roots of Taraxacum officinale (dandelion) have been found to be rich sources of polyphenols, including cinnamic acid derivatives, flavonoids and triterpenoids, which exert different biological activities, such as anti-inflammatory, anticancer and antimicrobial. Additionally, the whole plant is recognized as safe and well tolerated by humans, with no reported adverse effects. Nowadays, dandelion is a commonly available dietary supplement and a component of pharmaceutical preparations used for the treatment of bladder, liver, and spleen...
May 2018: Food Research International
https://www.readbyqxmd.com/read/29577867/platelet-activation-polymorphisms-in-ischemia
#10
Habib Haybar, Elahe Khodadi, Kazem Zibara, Najmaldin Saki
Ischemia is a multifactorial disorder in which several genetic and environmental factors are involved. Platelets are the major causative agents of this disease because their elevated activity and aggregation would increase the risk of atherosclerosis and thrombosis, as well as ischemia. A number of polymorphisms in platelet receptors can increase the risk of ischemia and single-nucleotide polymorphisms (SNPs) have been detected in platelets. In addition, polymorphisms in other genes have been shown to cause platelet adhesion and aggregation that plays a role in ischemia...
March 26, 2018: Cardiovascular & Hematological Disorders Drug Targets
https://www.readbyqxmd.com/read/29576056/brazilin-and-caesalpinia-sappan-l-extract-protect-epidermal-keratinocytes-from-oxidative-stress-by-inducing-the-expression-of-gpx7
#11
Hyung Seo Hwang, Joong Hyun Shim
Caesalpinia sappan L., belonging to the family Leguminosae, is a medicinal plant that is distributed in Southeast Asia. The dried heartwood of this plant is used as a traditional ingredient of food, red dyes, and folk medicines in the treatment of diarrhea, dysentery, tuberculosis, skin infections, and inflammation. Brazilin is the major active compound, which has exhibited various pharmacological effects, including anti-platelet activity, anti-hepatotoxicity, induction of immunological tolerance, and anti-inflammatory and antioxidant activities...
March 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29567577/development-of-atherosclerotic-moyamoya-syndrome-with-genetic-variant-of-rnf213-p-r4810k-and-p-t1727m-a-case-report
#12
Ying Liu, Xueying Wu, Zhaoyang Fan, Jingdan Cheng, Lele Zhong, Yongzhong Lin, Xiaofeng Qu
OBJECTIVE: We report a rare case of atherosclerotic-moyamoya syndrome (A-MMS) in an adult female with genetic variant of both ring finger 213 (RNF213) p.R4810K and p.T1727M. CASE REPORT: A 46-year-old previously healthy, right-handed woman displayed transient slurred speech, which started to worsen four years ago. Initial magnetic resonance angiography (MRA) revealed stenosis in left middle cerebral artery (MCA), bilateral anterior cerebral artery (ACA), and left posterior cerebral artery (PCA)...
February 2, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29566852/role-of-medical-therapy-in-the-management-of-uterine-adenomyosis
#13
REVIEW
Silvia Vannuccini, Stefano Luisi, Claudia Tosti, Flavia Sorbi, Felice Petraglia
Adenomyosis is a benign uterine condition affecting women at various ages with different symptoms. The management of these patients is still controversial. Few clinical studies focusing on medical or surgical treatment for adenomyosis have been performed. No drug is currently labelled for adenomyosis and there are no specific guidelines to follow for the best management. Anyhow, medical treatments are effective in improving symptoms (pain, abnormal uterine bleeding and infertility). The rationale for using medical treatment is based on the pathogenetic mechanisms of adenomyosis: sex steroid hormones aberrations, impaired apoptosis, and increased inflammation...
March 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29564352/management-of-sequelae-of-kawasaki-disease-in-adults
#14
REVIEW
John B Gordon, Jane C Burns
Background: A growing population of young adults is presenting to cardiologists with late manifestations of Kawasaki disease (KD) that include cardiomyopathy, ischemia, and infarction. The management of these conditions differs in important ways from atherosclerotic heart disease, and yet there is little awareness in the adult cardiology community regarding the special challenges posed by the cardiovascular sequelae of KD. Methods: Observations were made on a population of 140 adult KD patients enrolled in the San Diego Adult KD Collaborative Study...
October 31, 2017: Global Cardiology Science & Practice
https://www.readbyqxmd.com/read/29562586/correlation-between-antiplatelet-therapy-in-secondary-prevention-of-acute-cerebral-infarction-and-cerebral-microbleeds-a-susceptibility-weighted-imaging-swi-study
#15
Caiyun Jia, Ci Wei, Ming Hu, Jing Xu, Kun Niu, Chao Zhang, Peiyuan Lv, Ling Li, Yanhong Dong
OBJECTIVE: To investigate the clinical significance of antiplatelet aggregation therapy for patients diagnosed with acute cerebral infarction (ACI) complicated with the cerebral microbleeds (CMBs). METHODS: Thirty patients with ACI and 36 patients with intracerebral hemorrhage (ICH) were included in this research. Two groups, studied by susceptibility-weighted imaging (SWI), were compared in terms of the number, location, and severity of CMBs. Then, 30 cases of ACI patients were divided into CMBs sub-group and non-CMBs sub-group...
March 15, 2018: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/29562422/-predictive-value-of-the-grace-discharge-score-on-the-long-term-out-of-hospital-coronary-thrombotic-events-after-implantation-of-drug-eluting-stents
#16
X Y Zhao, J X Li, X F Tang, Y Xian, J J Xu, Y Song, L Jiang, L J Xu, J Chen, Y Zhang, L Song, L J Gao, Z Gao, J Zhang, Y Wu, S B Qiao, Y J Yang, R L Gao, B Xu, J Q Yuan
Objective: To evaluate the predictive value of GRACE discharge score on the long-term out-of-hospital coronary thrombotic events (CTE) after percutaneous coronary intervention (PCI) with drug-eluting stents. Methods: Present study was a prospective, observational, single center study. 10 724 consecutive patients underwent PCI in Fuwai Hospital between January and December 2013 were included, stents were implanted with conventional method. After PCI, patients were prescribed aspirin 100 mg once daily indefinitely, and either clopidogrel 75 mg once daily or ticagrelor 90 mg twice daily for at least 1 year...
March 24, 2018: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29555531/anti-platelet-therapy-does-not-influence-the-outcome-of-patients-undergoing-hepatic-resection-for-colorectal-liver-metastases-an-observational-study
#17
H Boyd-Carson, G Irving, A P Navarro, I C Cameron, D Gomez
AIM: To evaluate the impact of anti-platelet therapy on the outcomes of patients undergoing liver resection for CRLM. Secondary aim was to determine whether anti-platelet therapy influenced histo-pathological changes in CRLM. METHODS: Patients treated with liver resection for CRLM were identified from a prospectively maintained hepatobiliary database during an 11-year period. Collated data included demographics, primary tumour treatment, surgical data, histopathology analysis and clinical outcome...
March 16, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29554005/cyp2c19-genotype-is-an-independent-predictor-of-adverse-cardiovascular-outcome-in-iraqi-patients-on-clopidogrel-post-percutaneous-coronary-intervention
#18
Ameen M Mohammad Fic, Nasir As Al-Allawi
To determine the impact of CYP2C19 genotyping on the occurrence of major adverse cardiovascular events (MACE), in cohort of Iraqi patients on clopidogrel post percutaneous coronary intervention (PCI), a total of 201 Iraqi patients undergoing the latter procedure were enrolled. All enrollees had their CYP2C19 genotyped using PCR and reverse hybridization. Genotyping revealed that CYP2C19 *1, *17, *2 and *8 allele frequencies were respectively 0.604, 0.276, 0.117 and 0.0026. After the exclusion of those with two loss of function alleles, 186 patients were available for follow-up as long as they were on clopidogrel, or until MACE occurred, which was encountered in 8...
March 12, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29553426/management-of-acute-ischaemic-stroke-at-nasser-hospital-gaza-strip-a-clinical-audit
#19
Mohammed N Alkhatib, Tamer Abd-Alghafoor, AlaaEldeen Elmassry, Loai Albarqouni, Bettina Böttcher, Maha Alfaqawi
BACKGROUND: Stroke is a leading cause of morbidity and mortality worldwide. The aim of this study was to assess the standard of care for patients with acute ischaemic stroke at the internal medicine department of Nasser Hospital, Gaza Strip. METHODS: For this retrospective clinical audit, we selected a random sample of 100 medical records for patients with stroke who were admitted to Nasser Hospital between January and August, 2016. Clinical practice was compared with the recommendations in the 2013 American Heart Association and American Stroke Association guidelines...
February 21, 2018: Lancet
https://www.readbyqxmd.com/read/29545875/enhanced-percutaneous-absorption-of-cilostazol-nanocrystals-using-aqueous-gel-patch-systems-and-clarification-of-the-absorption-mechanism
#20
Chiaki Yoshioka, Yoshimasa Ito, Noriaki Nagai
Cilostazol (CLZ), an anti-platelet agent, is primarily used following the onset of cerebral infarction. However, as CLZ is only marginally soluble in water, a strategy for patients with serious secondary conditions, such as impaired consciousness or aphagia, is required. In the present study, topical formulations containing CLZ nanocrystals (CLZnano ) were designed to enhance percutaneous absorption. In addition, the mechanism of penetration of CLZnano through rat skin was investigated. A topical formulation containing CLZ nanoparticles (CLZnano gel patch) was prepared using a combination of recrystallization and ball milling of an aqueous gel...
April 2018: Experimental and Therapeutic Medicine
keyword
keyword
12157
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"