Han-Ting Huang, Ching-Yuan Huang, Chih-Jou Lee, Bo-Jie Sun, Zong-Wei Jhang, Chi-Chung Wen, Yun-Hsin Wang, Tao-Sheng Li, Ching-Yuh Chern, Yau-Hung Chen
Coumarin is a natural compound that is rich in plants. Coumarin and its derivates were reported to have many biological activities, such as anti-bacterial, anti-tumor, and anti-coagulation. In this study, we examined the angiogenic modulating activities of six previously synthesized coumarin derivatives (Compound #1-#6) in zebrafish embryos and further confirmed them in a chick model. According to the survival rate in a zebrafish model, Compound #1 (100 %), #2 (82.5-100 %), and #4 (100 %) showed much less toxicity than Compound #3 (19...
February 19, 2024: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP