keyword
MENU ▼
Read by QxMD icon Read
search

Xist

keyword
https://www.readbyqxmd.com/read/28923964/repeat-e-anchors-xist-rna-to-the-inactive-x-chromosomal-compartment-through-cdkn1a-interacting-protein-ciz1
#1
Hongjae Sunwoo, David Colognori, John E Froberg, Yesu Jeon, Jeannie T Lee
X chromosome inactivation is an epigenetic dosage compensation mechanism in female mammals driven by the long noncoding RNA, Xist. Although recent genomic and proteomic approaches have provided a more global view of Xist's function, how Xist RNA localizes to the inactive X chromosome (Xi) and spreads in cis remains unclear. Here, we report that the CDKN1-interacting zinc finger protein CIZ1 is critical for localization of Xist RNA to the Xi chromosome territory. Stochastic optical reconstruction microscopy (STORM) shows a tight association of CIZ1 with Xist RNA at the single-molecule level...
September 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28894175/sexual-congruency-in-the-connectome-and-translatome-of-vta-dopamine-neurons
#2
Amanda S Chung, Samara M Miller, Yanjun Sun, Xiangmin Xu, Larry S Zweifel
The ventral tegmental area (VTA) dopamine system is important for reward, motivation, emotion, learning, and memory. Dysfunctions in the dopamine system are linked to multiple neurological and neuropsychiatric disorders, many of which present with sex differences. Little is known about the extent of heterogeneity in the basic organization of VTA dopamine neurons with regard to sex. Here, we characterized the cell-specific connectivity of VTA dopamine neurons, their mRNA translational profile, and basic electrophysiological characteristics in a common strain of mice...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28869948/the-long-non-coding-rna-xist-interacted-with-mir-124-to-modulate-bladder-cancer-growth-invasion-and-migration-by-targeting-androgen-receptor-ar
#3
Yaoyao Xiong, Long Wang, Yuan Li, Minfeng Chen, Wei He, Lin Qi
BACKGROUNDS/AIMS: Long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) is involved in the progression of several tumors. The interaction between lncRNA and miRNA or miRNA's target genes is reported to play crucial roles in malignancy. In addition, Androgen receptor (AR) is considered to be involved in bladder cancer progression. In this study, we investigated the role of XIST in human bladder cancer and its interaction with miR-124 and AR. METHODS: XIST and AR expression was detected in bladder tumor samples and cell lines...
August 31, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28843909/rsf1-functions-as-an-oncogene-in-osteosarcoma-and-is-regulated-by-xist-mir-193a-3p-axis
#4
Dapeng Wu, Xingguo Nie, Chao Ma, Xianghua Liu, Xue Liang, Yongbo An, Bin Zhao, Xuejian Wu
RSF1 (HBXAP), is a member of ATP-dependent chromatin remodeling factor. Dysregulated RSF1 has been reported to be related to tumor progression. However, the function of RSF1 in osteosarcoma (OS) remains unclear. In this study, we showed that RSF1 expression was upregulated in OS cells. RSF1 inhibition suppressed OS cell proliferation and invasion. We further showed that MAPK/Erk signaling pathway was inactivated by RSF1 suppression. In addition, RSF1 was identified as a direct target of miR-193a-3p. Clinically, RSF1 was increased and associated with advanced clinical features and poor overall survival of OS patients...
August 24, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28837144/long-noncoding-rna-xist-expedites-metastasis-and-modulates-epithelial-mesenchymal-transition-in-colorectal-cancer
#5
Dong-Liang Chen, Le-Zong Chen, Yun-Xin Lu, Dong-Sheng Zhang, Zhao-Lei Zeng, Zhi-Zhong Pan, Peng Huang, Feng-Hua Wang, Yu-Hong Li, Huai-Qiang Ju, Rui-Hua Xu
Tumor progression and metastasis is the main cause of death in colorectal cancer (CRC). Long noncoding RNAs (lncRNAs) are critical regulators in various diseases including human cancer. In this study, we found that lncRNA XIST was overexpressed in CRC cell lines and tissues. High expression of lncRNA XIST was associated with adverse overall survival in CRC patients. Knockdown of lncRNA XIST remarkably inhibited CRC cell proliferation, invasion, epithelial-mesenchymal transition (EMT) and CRC stem cell formation in vitro as well as tumor growth and metastasis in vivo...
August 24, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28831025/lncrna-xist-interacts-with-mir-29c-to-modulate-the-chemoresistance-of-glioma-cell-to-tmz-through-dna-mismatch-repair-pathway
#6
Peng Du, Haiting Zhao, Renjun Peng, Qing Liu, Jian Yuan, Gang Peng, Yiwei Liao
Temozolomide (TMZ) is the most commonly used alkylating agent in glioma chemotherapy. However, growing resistance to TMZ remains a major challenge for clinicians. Recent evidence emphasizes the key regulatory roles of non-coding RNAs (lncRNAs and miRNAs) in tumor biology, including the chemoresistance of cancers. However, little is known about the role and regulation mechanisms of lncRNA cancer X-inactive specific transcripts (XIST) in glioma tumorigenesis and chemotherapy resistance. In the present study, higher XIST expression was observed in glioma tissues and cell lines, which was related to poorer clinicopathologic features and shorter survival time...
October 31, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28815535/history-discovery-and-classification-of-lncrnas
#7
Julien Jarroux, Antonin Morillon, Marina Pinskaya
The RNA World Hypothesis suggests that prebiotic life revolved around RNA instead of DNA and proteins. Although modern cells have changed significantly in 4 billion years, RNA has maintained its central role in cell biology. Since the discovery of DNA at the end of the nineteenth century, RNA has been extensively studied. Many discoveries such as housekeeping RNAs (rRNA, tRNA, etc.) supported the messenger RNA model that is the pillar of the central dogma of molecular biology, which was first devised in the late 1950s...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28771809/role-of-xist-mir-29a-lin28a-pathway-in-denatured-dermis-and-human-skin-fibroblasts-hsfs-after-thermal-injury
#8
Le Guo, Xu Huang, Pengfei Liang, Pihong Zhang, Minghua Zhang, Licheng Ren, Jizhang Zeng, Xv Cui, Xiaoyuan Huang
Denatured dermis is a part of the dermis in deep burn wound and has the ability to restore normal morphology and function. In our previous study, we revealed that miR-29a downregulation in denatured dermis may help burn wound healing in the later phase, and further enhance type I collagen synthesis. LIN28A, a highly-conserved RNA binding protein expressed during embryogenesis, plays roles in development, pluripotency, metabolism, as well as tissue repair in adults. In the present study, we investigated the functional roles of LIN28A in human skin fibroblasts (HSFs) and extracellular matrix (ECM), and the interaction between miR-29a and LIN28A...
August 3, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28767436/rnai-mediated-knockdown-of-parp1-does-not-improve-the-development-of-female-cloned-mouse-embryos
#9
Guang-Yu Bai, Si-Hang Song, Rui-Zhen Sun, Zi-Hui Zhang, Jingyu Li, Zhen-Dong Wang, Zhong-Hua Liu, Lei Lei
Somatic cell nuclear transfer is an important technique for life science research, but its efficiency is still extremely low, and most genes that are important during early development, such as X chromosome-linked genes, are not appropriately expressed during this process. Poly (ADP-ribose) polymerase (PARP) is an enzyme that transfers ADP ribose clusters to target proteins. PARP family members such as PARP1 participate in cellular signalling pathways through poly (ADP-ribosylation) (PARylation), which ultimately promotes changes in chromatin structure, gene expression, and the localization and activity of proteins that mediate signalling responses...
July 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28766050/unique-xci-evolution-in-tokudaia-initial-xci-of-the-neo-x-chromosome-in-tokudaia-muenninki-and-function-loss-of-xist-in-tokudaia-osimensis
#10
Hideki Zushi, Chie Murata, Shusei Mizushima, Chizuko Nishida, Asato Kuroiwa
X chromosome inactivation (XCI) is an essential mechanism to compensate gene dosage in mammals. Here, we show that XCI has evolved differently in two species of the genus Tokudaia. The Amami spiny rat, Tokudaia osimensis, has a single X chromosome in males and females (XO/XO). By contrast, the Okinawa spiny rat, Tokudaia muenninki, has XX/XY sex chromosomes like most mammals, although the X chromosome has acquired a neo-X region by fusion with an autosome. BAC clones containing the XIST gene, which produces the long non-coding RNA XIST required for XCI, were obtained by screening of T...
August 2, 2017: Chromosoma
https://www.readbyqxmd.com/read/28765214/epigenetic-resetting-of-human-pluripotency
#11
Ge Guo, Ferdinand von Meyenn, Maria Rostovskaya, James Clarke, Sabine Dietmann, Duncan Baker, Anna Sahakyan, Samuel Myers, Paul Bertone, Wolf Reik, Kathrin Plath, Austin Smith
Much attention has focussed on the conversion of human pluripotent stem cells (PSCs) to a more naïve developmental status. Here we provide a method for resetting via transient histone deacetylase inhibition. The protocol is effective across multiple PSC lines and can proceed without karyotype change. Reset cells can be expanded without feeders with a doubling time of around 24 h. WNT inhibition stabilises the resetting process. The transcriptome of reset cells diverges markedly from that of primed PSCs and shares features with human inner cell mass (ICM)...
August 1, 2017: Development
https://www.readbyqxmd.com/read/28730777/long-non-coding-rna-xist-functions-as-an-oncogene-in-human-colorectal-cancer-by-targeting-mir-132-3p
#12
Hui Song, Ping He, Tiansong Shao, Yang Li, Jin Li, Yajing Zhang
PURPOSE: Colorectal cancer (CRC) is a frequent malignant tumor with high death rate and poor prognosis. Few reports have explored the association between CRC development and long non-coding (lnc) RNAs expression. This study focused on the important role of a novel lncRNA XIST in the development of CRC. METHODS: To investigate the function of long lncRNA XIST in CRC, its expression level was monitored in both CRC cells and 50 pairs of human CRC tissues and adjacent tissues by RT-qPCR...
May 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28698395/long-noncoding-rna-xist-promotes-malignancies-of-esophageal-squamous-cell-carcinoma-via-regulation-of-mir-101-ezh2
#13
Xiaoliang Wu, Xiaoxiao Dinglin, Xing Wang, Wen Luo, Qi Shen, Yong Li, Ling Gu, Qianghua Zhou, Haotu Zhu, Yanjie Li, Chaodi Tan, Xianzi Yang, Zhenfeng Zhang
The long non-coding RNA XIST is a long non-coding RNA that associates with polycomb repressive complex 2 to regulate X-chromosome inactivation in female mammals. The biological roles as well as the underlying mechanisms of XIST in esophageal squamous cell carcinoma remained yet to be solved. Our data indicated that XIST was significantly upregulated in esophageal squamous cancerous tissues and cancer cell lines, as compared with that in the corresponding non-cancerous tissues and immortalized normal squamous epithelial cells...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28686623/xist-rna-repeat-e-is-essential-for-ash2l-recruitment-to-the-inactive-x-and-regulates-histone-modifications-and-escape-gene-expression
#14
Minghui Yue, Akiyo Ogawa, Norishige Yamada, John Lalith Charles Richard, Artem Barski, Yuya Ogawa
Long non-coding RNA Xist plays a crucial role in establishing and maintaining X-chromosome inactivation (XCI) which is a paradigm of long non-coding RNA-mediated gene regulation. Xist has Xist-specific repeat elements A-F which are conserved among eutherian mammals, underscoring their functional importance. Here we report that Xist RNA repeat E, a conserved Xist repeat element in the Xist exon 7, interacts with ASH2L and contributes to maintenance of escape gene expression level on the inactive X-chromosome (Xi) during XCI...
July 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28684628/defects-in-dosage-compensation-impact-global-gene-regulation-in-the-mouse-trophoblast
#15
Yuka Sakata, Koji Nagao, Yuko Hoki, Hiroyuki Sasaki, Chikashi Obuse, Takashi Sado
Xist RNA responsible for X inactivation is one of the most important epigenetic players for embryogenesis of female mammals. Of the several repeats conserved in Xist RNA, the A-repeat has been shown to be essential for its silencing function in differentiating ES cells. Here, we introduced a new Xist allele into the mouse, which produces mutated Xist RNA lacking the A-repeat (Xist(CAGΔ5') ). Xist(CAGΔ5') RNA expressed in the embryo coated the X chromosome but failed to silence it. Although imprinted X inactivation was substantially compromised upon paternal transmission, allele-specific RNA-seq in the trophoblast revealed that Xist(CAGΔ5') RNA still retained some silencing ability...
July 6, 2017: Development
https://www.readbyqxmd.com/read/28682435/high-expression-of-long-non-coding-rna-xist-in-osteosarcoma-is-associated-with-cell-proliferation-and-poor-prognosis
#16
G-L Li, Y-X Wu, Y-M Li, J Li
OBJECTIVE: Osteosarcoma is one of the most common primary bone malignancies. Long non-coding RNAs (lncRNAs) have recently emerged as key regulators of osteosarcoma. The aim of present study was to explore the prognostic value of long non-coding RNA XIST (XIST) in osteosarcoma and XIST's relation to the cell proliferation in osteosarcoma in vitro. PATIENTS AND METHODS: The XIST expressions were detected in osteosarcoma tissues and their paired adjacent normal tissues from 145 osteosarcoma patients by using qRT-PCR...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28663000/skewed-x-chromosome-inactivation-and-xist-locus-methylation-levels-do-not-contribute-to-the-lower-prevalence-of-parkinson-s-disease-in-females
#17
Amit Sharma, Oliver Kaut, Anna Pavlova, Holger Fröhlich, Ashar Ahmad, Ina Schmitt, Osman El-Maarri, Johannes Oldenburg, Ullrich Wüllner
Parkinson's disease (PD) is a degenerative disorder of the nervous system and the cause of the majority of sporadic cases is unknown. Females are relatively protected from PD as compared with males and linkage studies suggested a PD susceptibility locus on the X chromosome. To determine a putative association of skewed X-chromosome inactivation (XCI) and PD, we examined XCI patterns using a human androgen receptor gene-based assay (HUMARA) and did not identify any association of skewed or random X inactivation with clinical heterogeneity among female PD patients...
September 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28656261/lncrna-xist-interacts-with-mir-140-to-modulate-lung-cancer-growth-by-targeting-iaspp
#18
Yongjun Tang, Ruoxi He, Jian An, Pengbo Deng, Li Huang, Wei Yang
X-inactive specific transcript (XIST), one of the first found cancer-associated long non-coding RNAs (lncRNAs), is involved in the development and progression of many types of tumors. Aberrant expression of XIST has been observed in hepatocellular carcinoma, cervical, breast, ovarian and colorectal cancer. However, the exact effects and molecular mechanisms of XIST in lung cancer progression are still unknown to date. In the present study, we investigated the role of XIST in human lung cancer cell lines and clinical tumor samples in order to determine the function of this molecule...
August 2017: Oncology Reports
https://www.readbyqxmd.com/read/28621667/xist-mir-139-axis-regulates-bleomycin-blm-induced-extracellular-matrix-ecm-and-pulmonary-fibrosis-through-%C3%AE-catenin
#19
Yichun Wang, Ying Liang, Junming Luo, Jing Nie, Huiming Yin, Qiong Chen, Jing Dong, Jixiang Zhu, Jiamei Xia, Wei Shuai
Pulmonary fibrosis (PF), characterized by the destruction of lung tissue architecture and the abnormal deposition of extracellular matrix (ECM) proteins, currently has no satisfactory treatment. In the present study, we investigated the hypothesis that XIST play a promotive role in bleomycin (BLM)-induced ECM and pulmonary fibrosis; XIST exerts its effect through miR-139 regulation. XIST expression was upregulated in lung tissues derived from BLM-induced mouse model of PF, and was positively correlated with β-catenin and ECM protein levels, respectively...
May 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/28619888/response-to-comment-on-xist-recruits-the-x-chromosome-to-the-nuclear-lamina-to-enable-chromosome-wide-silencing
#20
Chun-Kan Chen, Amy Chow, Mason Lai, Mitchell Guttman
Wang et al question whether Lamin B receptor is required for Xist-mediated silencing because they claim that our cells contain an inversion rather than a deletion. We present evidence that these cells contain a proper deletion and that the confusion is caused by DNA probes used in the experiment. Accordingly, the points raised have no effect on the conclusions in our paper.
June 16, 2017: Science
keyword
keyword
12155
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"