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https://www.readbyqxmd.com/read/29773953/mir-34a-mediated-regulation-of-xist-in-female-cells-under-inflammation
#1
Botros B Shenoda, Yuzhen Tian, Guillermo M Alexander, Enrique Aradillas-Lopez, Robert J Schwartzman, Seena K Ajit
Background: Evidence is overwhelming for sex differences in pain, with women representing the majority of the chronic pain patient population. There is a need to explore novel avenues to elucidate this sex bias in the development of chronic inflammatory pain conditions. Complex regional pain syndrome (CRPS) is a chronic neuropathic pain disorder, and the incidence of CRPS is greater in women than in men by ~4:1. Since neurogenic inflammation is a key feature of CRPS, dysregulation of inflammatory responses can be a factor in predisposing women to chronic pain...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29772549/long-non-coding-rna-and-polycomb-an-intricate-partnership-in-cancer-biology
#2
Cyrinne Achour, Francesca Aguilo
High-throughput analyses have revealed that the vast majority of the transcriptome does not code for proteins. These non-translated transcripts, when larger than 200 nucleotides, are termed long non-coding RNAs (lncRNAs), and play fundamental roles in diverse cellular processes. LncRNAs are subject to dynamic chemical modification, adding another layer of complexity to our understanding of the potential roles that lncRNAs play in health and disease. Many lncRNAs regulate transcriptional programs by influencing the epigenetic state through direct interactions with chromatin-modifying proteins...
June 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/29752340/long-non-coding-rna-xist-predicts-worse-prognosis-in-digestive-system-tumors-a-systemic-review-and-meta-analysis
#3
Xuefang Liu, Xinliang Ming, Wei Jing, Ping Luo, Nandi Li, Man Zhu, Mingxia Yu, Chunzi Liang, Jiancheng Tu
Aims: Increasing studies are indicating that long non-coding RNA X-inactive specific transcript (XIST) is associated with the prognosis of cancer patients. However, the results have been disputed. Therefore, we aimed to further explore the prognostic value and clinical significance of XIST in various types of cancers. Then, we focused our research on the comparison of the predictive value of XIST between digestive system tumors and non-digestive system tumors. Methods: We performed a systematic search by looking up PubMed, Embase, Cochrane Library, Web of Science, and Medline (up to January 3, 2018)...
May 11, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29747568/classical-fragile-x-phenotype-in-a-female-infant-disclosed-by-comprehensive-genomic-studies
#4
Paula Jorge, Elsa Garcia, Ana Gonçalves, Isabel Marques, Nuno Maia, Bárbara Rodrigues, Helena Santos, Jacinta Fonseca, Gabriela Soares, Cecília Correia, Margarida Reis-Lima, Vincenzo Cirigliano, Rosário Santos
BACKGROUND: We describe a female infant with Fragile-X syndrome, with a fully expanded FMR1 allele and preferential inactivation of the homologous X-chromosome carrying a de novo deletion. This unusual and rare case demonstrates the importance of a detailed genomic approach, the absence of which could be misguiding, and calls for reflection on the current clinical and diagnostic workup for developmental disabilities. CASE PRESENTATION: We present a female infant, referred for genetic testing due to psychomotor developmental delay without specific dysmorphic features or relevant family history...
May 10, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29734339/lncrna-jpx-induces-xist-expression-in-mice-using-both-trans-and-cis-mechanisms
#5
Sarah Carmona, Benjamin Lin, Tristan Chou, Katti Arroyo, Sha Sun
Mammalian X chromosome dosage compensation balances X-linked gene products between sexes and is coordinated by the long noncoding RNA (lncRNA) Xist. Multiple cis and trans-acting factors modulate Xist expression; however, the primary competence factor responsible for activating Xist remains a subject of dispute. The lncRNA Jpx is a proposed competence factor, yet it remains unknown if Jpx is sufficient to activate Xist expression in mice. Here, we utilize a novel transgenic mouse system to demonstrate a dose-dependent relationship between Jpx copy number and ensuing Jpx and Xist expression...
May 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29706539/the-ftx-noncoding-locus-controls-x-chromosome-inactivation-independently-of-its-rna-products
#6
Giulia Furlan, Nancy Gutierrez Hernandez, Christophe Huret, Rafael Galupa, Joke Gerarda van Bemmel, Antonio Romito, Edith Heard, Céline Morey, Claire Rougeulle
Accumulation of the Xist long noncoding RNA (lncRNA) on one X chromosome is the trigger for X chromosome inactivation (XCI) in female mammals. Xist expression, which needs to be tightly controlled, involves a cis-acting region, the X-inactivation center (Xic), containing many lncRNA genes that evolved concomitantly to Xist from protein-coding ancestors through pseudogeneization and loss of coding potential. Here, we uncover an essential role for the Xic-linked noncoding gene Ftx in the regulation of Xist expression...
April 20, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29701779/the-exceptional-nature-of-the-x-chromosome
#7
Bradley P Balaton, Thomas Dixon-McDougall, Samantha B Peeters, Carolyn J Brown
The X chromosome is unique in the genome. In this review we discuss recent advances in our understanding of the genetics and epigenetics of the X chromosome. The X chromosome shares limited conservation with its ancestral homologue the Y chromosome and the resulting difference in X chromosome dosage between males and females is largely compensated for by X-chromosome inactivation. The process of inactivation is initiated by the long non-coding RNA XIST and achieved through interaction with multiple synergistic silencing pathways...
April 26, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29679755/long-non-coding-rna-xist-sponges-mir-34a-to-promotes-colon-cancer-progression-via-wnt-%C3%AE-catenin-signaling-pathway
#8
Ningning Sun, Guozun Zhang, Yingying Liu
Little is known about the role of long non-coding RNA XIST in the development of colon cancer. The aim of the present study was to investigate the levels of XIST in colon cancer, and explore its underlying mechanism. In this study, we found XIST expression level was upregulated in colon cancer tissues and cell lines. In addition, the growth rate of cells transfected with si-XIST was significantly decreased compared to that with si-NC, which was reversed by miR-34a targeted with 3'-UTR. Moreover, miR-34a suppressed the expression of WNT1 by binding with the 3'-UTR, which interact with WNT1 to inhibit the proliferation of cells...
April 18, 2018: Gene
https://www.readbyqxmd.com/read/29669321/lncrna-expression-profile-of-human-thoracic-aortic-dissection-by-high-throughput-sequencing
#9
Jie Sun, Guojun Chen, Yuanwen Jing, Xiang He, Jianting Dong, Junmeng Zheng, Meisheng Zou, Hairui Li, Shifei Wang, Yili Sun, Wangjun Liao, Yulin Liao, Li Feng, Jianping Bin
BACKGROUND/AIMS: In this study, the long non-coding RNA (lncRNA) expression profile in human thoracic aortic dissection (TAD), a highly lethal cardiovascular disease, was investigated. METHODS: Human TAD (n=3) and normal aortic tissues (NA) (n=3) were examined by high-throughput sequencing. Bioinformatics analyses were performed to predict the roles of aberrantly expressed lncRNAs. Quantitative real-time polymerase chain reaction (qRT-PCR) was applied to validate the results...
April 13, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29577911/long-non-coding-rna-xist-as-a-prognostic-cancer-marker-a-meta-analysis
#10
REVIEW
Qun Zhou, Wei Hu, Wei Zhu, Feng Zhang, Li Lin-Lin, Cong Liu, Yi-Yan Songyang, Cheng-Cao Sun, Dejia Li
BACKGROUND: The X inactivate-specific transcript (XIST), derived from XIST gene, is aberrantly expressed in various cancers. High-expression of XIST is related to poor clinical outcome. This meta-analysis evaluated the potential role of XIST as novel predictor of prognosis in human cancer. MATERIALS AND METHODS: This meta-analysis collected eligible studies about XIST and tumor prognosis through retrieving keywords in Web of Science, PubMed, Embase and the CNKI database, from 1993 to August 21, 2017...
March 23, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29568404/long-non-coding-rna-xist-as-a-potential-prognostic-biomarker-in-human-cancers-a-meta-analysis
#11
Shaopu Hu, Junli Chang, Yimian Li, Wenyi Wang, Mengyao Guo, Edward C Zou, Yongjun Wang, Yanping Yang
Growing studies have confirmed that long non-coding RNAs (lncRNAs) involve in the occurrence and development of various cancers. XIST, as a lncRNA, was dysregulated in different cancers. This meta-analysis was performed to evaluate the prognostic potential of XIST in malignant tumors. Eight databases of PubMed, Web of Science, Embase, Cochrane library, CNKI, VIP, SinoMed and Wang Fang were comprehensively searched from their initiation date to August 15, 2017. A total of nine studies with 853 cancer patients met the including criteria were finally included in this meta-analysis after independently screening the literatures by two researchers...
March 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29559853/lncrna-xist-mir-200c-regulates-the-stemness-properties-and-tumourigenicity-of-human-bladder-cancer-stem-cell-like-cells
#12
Ran Xu, Xuan Zhu, Fangzhi Chen, Changkun Huang, Kai Ai, Hongtao Wu, Lei Zhang, Xiaokun Zhao
Background: The abnormal expression of non-coding RNAs (ncRNAs), such as microRNAs and long ncRNAs, often contribute to the development of cancers. miR-200c functions as a tumour suppressor that impacts the growth of bladder cancer cells and the epithelial-to-mesenchymal transition (EMT). LncRNA X inactive specific transcript (XIST) is highly expressed in tumour tissues, promotes cancer progression and might act as an miRNA molecular sponge. This study aimed to examine the relationship between lncRNA XIST and miR-200c and to assess their functions in the regulation of the stemness properties and tumourigenicity of human bladder cancer stem cell (BCSC)-like cells...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/29556138/prognostic-role-of-long-non-coding-rna-xist-expression-in-patients-with-solid-tumors-a-meta-analysis
#13
REVIEW
Huihui Mao, Kai Wang, Yuehua Feng, Jun Zhang, Lili Pan, Yuxia Zhan, Haijun Sheng, Guanghua Luo
Background: The aberrant expression of long non-coding RNA (lncRNA) X inactivate-specific transcript (XIST) has been demonstrated to be involved in the tumourigenesis and the development of various cancers. Therefore, we conducted a meta-analysis to assess the prognostic role of lncRNA XIST expression in solid tumors. Methods: The databases of PubMed, EMBase, Web of Science, Cochrane library (up to Dec 31, 2017) were searched for the related studies and identified 15 eligible studies containing 1209 patients to include in the meta-analysis...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/29550489/long-non-coding-rna-xist-inhibited-breast-cancer-cell-growth-migration-and-invasion-via-mir-155-cdx1-axis
#14
Ruinian Zheng, Shunhuan Lin, Ling Guan, Huiling Yuan, Kejun Liu, Chun Liu, Weibiao Ye, Yuting Liao, Jun Jia, Ruopeng Zhang
Long non-coding RNA (lncRNA) is an important member of non-coding RNA family and emerging evidence has indicated that it plays a pivotal role in many physiological and pathological processes. The lncRNA X inactive specific transcript (XIST) is a potential tumour suppressor in some types of cancers. However, the expression and function of XIST in breast cancer remain largely unclear. The objective of this study was to evaluate the expression and biological role of XIST in breast cancer. The results showed that XIST was significantly down-regulated in breast cancer tissues and cell lines...
April 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29546464/chromosome-wide-gene-dosage-rebalance-may-benefit-tumor-progression
#15
Honglei Zhang, Xing Yang, Xu Feng, Haibo Xu, Qin Yang, Li Zou, Mei Yan, Dequan Liu, Xiaosan Su, Baowei Jiao
The high-risk of tumor initiation in patients with Turner syndrome (TS) characterized by X chromosome monosomy in women has been well established and aneuploidy, defined as an abnormal number of chromosomes, is a common feature in human cancer. However, the underlying mechanisms of X chromosome aneuploidy promoting tumorigenesis remain obscure. We propose that chromosome-wide gene dosage imbalance (CDI) may serve as an important mechanism. Here, we assess the relative expression ratios of X chromosome and autosomes (expression ratios of X:AA) between tumor samples and adjacent normal samples across 16 tumor types using expression datasets from The Cancer Genome Atlas (TCGA) project...
March 15, 2018: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/29495975/long-non-coding-rna-xist-regulates-mir-137-ezh2-axis-to-promote-tumor-metastasis-in-colorectal-cancer
#16
Xingxiang Liu, Lin Cui, Dong Hua
We aimed to investigate the significant role of long non-coding RNA X Inactive Specific Transcript (XIST) in regulatingtumor metastasis in colorectal cancer (CRC), as well as its possible mechanism. Expression of lncRNA XIST in CRC tissues and CRC cells was detected. CRC cells were transfected with pc-XIST, blank control si-XIST or si-control, and then the effects of lncRNA XIST on CRC cell migration and invasion were investigated, along with the interaction between lncRNA XIST and miR-137. LncRNA XIST was upregulated in CRC tissues...
March 1, 2018: Oncology Research
https://www.readbyqxmd.com/read/29484395/identification-of-candidate-genes-and-long-non-coding-rnas-associated-with-the-effect-of-atp5j-in-colorectal-cancer
#17
Bingjun Bai, Binbin Xie, Zongyou Pan, Lina Shan, Jianpei Zhao, Hongbo Zhu
The incidence and development of colorectal cancer (CRC) is a process with multiple gene interactions. We have previously demonstrated that ATP synthase-coupling factor 6, mitochondrial (ATP5J) is associated with CRC migration and 5-fluorouracil resistance; nevertheless, the exact molecular mechanism remains unclear. The following study uses microarray and bioinformatics methods to identify candidate genes and long non-coding RNAs (lncRNAs) in CRC cells (two pairs) with upregulated and downregulated ATP5J...
April 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29459759/genomics-of-a-pediatric-ovarian-fibrosarcoma-association-with-the-dicer1-syndrome
#18
Jorge Melendez-Zajgla, Gabriela E Mercado-Celis, Javier Gaytan-Cervantes, Amada Torres, Nayeli Belem Gabiño, Martha Zapata-Tarres, Luis Enrique Juarez-Villegas, Pablo Lezama, Vilma Maldonado, Karen Ruiz-Monroy, Elvia Mendoza-Caamal
Ovarian fibrosarcomas are extremely rare tumors with little genomic information available to date. In the present report we present the tumoral exome and transcriptome and the germinal exome of an ovarian fibrosarcoma from a 9-years old child. We found a paucity of mutations (0.77/Mb) and CNV alterations. Of these, the most relevant were a point mutation in the metal-binding site of the microRNA-processing DICER1 enzyme and a frame-shift alteration in the tumor suppressor gene NF1. We validated a germinal truncating mutation in DICER1, which was consistent with a DICER1 Syndrome diagnosis, providing the first example of an ovarian fibrosarcoma as the presenting neoplasia in this syndrome...
February 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29408376/hictmap-detection-and-analysis-of-chromosome-territory-structure-and-position-by-high-throughput-imaging
#19
Ziad Jowhar, Prabhakar R Gudla, Sigal Shachar, Darawalee Wangsa, Jill L Russ, Gianluca Pegoraro, Thomas Ried, Armin Raznahan, Tom Misteli
The spatial organization of chromosomes in the nuclear space is an extensively studied field that relies on measurements of structural features and 3D positions of chromosomes with high precision and robustness. However, no tools are currently available to image and analyze chromosome territories in a high-throughput format. Here, we have developed High-throughput Chromosome Territory Mapping (HiCTMap), a method for the robust and rapid analysis of 2D and 3D chromosome territory positioning in mammalian cells...
February 10, 2018: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29393501/long-non-coding-rna-xist-exerts-oncogenic-functions-in-pancreatic-cancer-via-mir-34a-5p
#20
Zhixia Sun, Baogang Zhang, Tingting Cui
Long non-coding RNAs (lncRNAs) have been implicated in the occurrence and progression of multiple cancers. In the present study, we investigated the role of lncRNA X inactive-specific transcript (XIST) in the development and progression of pancreatic cancer (PC). Firstly, we found that lncRNA XIST was markedly upregulated in PC tissues and PC cell lines, respectively. Overexpression of XIST significantly promoted the proliferation, migration and invasion, and suppressed cell apoptosis of BxPC-3 cells; knockdown of XIST significantly inhibited the proliferation, migration and invasion, and accelerated cell apoptosis of PANC-1 cells...
April 2018: Oncology Reports
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