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https://www.readbyqxmd.com/read/28926060/mg-doped-li2fesio4-c-nanocomposites-synthesized-by-the-solvothermal-method-for-lithium-ion-batteries
#1
Ajay Kumar, O D Jayakumar, Jagannath, Parisa Bashiri, G A Nazri, Vaman M Naik, Ratna Naik
A series of porous Li2Fe1-xMgxSiO4/C (x = 0, 0.01, 0.02, 0.04) nanocomposites (LFS/C, 1Mg-LFS/C, 2Mg-LFS and 4Mg-LFS/C) have been synthesized via a solvo-thermal method using the Pluronic P123 polymer as an in situ carbon source. Rietveld refinement of the X-ray diffraction data of Li2Fe1-xMgxSiO4/C composites confirms the formation of the monoclinic P21 structure of Li2FeSiO4. The addition of Mg facilitates the growth of impurity-free Li2FeSiO4 with increased crystallinity and particle size. Despite having the same percentage of carbon content (∼15 wt%) in all the samples, the 1Mg-LFS/C nanocomposite delivered the highest initial discharge capacity of 278 mA h g(-1) (∼84% of the theoretical capacity) at the C/30 rate and also exhibited the best rate capability and cycle stability (94% retention after 100 charge-discharge cycles at 1C)...
September 19, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28925999/an-evaluation-of-the-effects-of-intensity-and-duration-on-outcomes-across-treatment-domains-for-children-with-autism-spectrum-disorder
#2
E Linstead, D R Dixon, E Hong, C O Burns, R French, M N Novack, D Granpeesheh
Applied behavior analysis (ABA) is considered an effective treatment for individuals with autism spectrum disorder (ASD), and many researchers have further investigated factors associated with treatment outcomes. However, few studies have focused on whether treatment intensity and duration have differential influences on separate skills. The aim of the current study was to investigate how treatment intensity and duration impact learning across different treatment domains, including academic, adaptive, cognitive, executive function, language, motor, play, and social...
September 19, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28925997/precision-annotation-of-digital-samples-in-ncbi-s-gene-expression-omnibus
#3
Dexter Hadley, James Pan, Osama El-Sayed, Jihad Aljabban, Imad Aljabban, Tej D Azad, Mohamad O Hadied, Shuaib Raza, Benjamin Abhishek Rayikanti, Bin Chen, Hyojung Paik, Dvir Aran, Jordan Spatz, Daniel Himmelstein, Maryam Panahiazar, Sanchita Bhattacharya, Marina Sirota, Mark A Musen, Atul J Butte
The Gene Expression Omnibus (GEO) contains more than two million digital samples from functional genomics experiments amassed over almost two decades. However, individual sample meta-data remains poorly described by unstructured free text attributes preventing its largescale reanalysis. We introduce the Search Tag Analyze Resource for GEO as a web application (http://STARGEO.org) to curate better annotations of sample phenotypes uniformly across different studies, and to use these sample annotations to define robust genomic signatures of disease pathology by meta-analysis...
September 19, 2017: Scientific Data
https://www.readbyqxmd.com/read/28925363/generation-of-an-induced-pluripotent-stem-cell-line-from-a-patient-with-hereditary-multiple-endocrine-neoplasia-2b-men2b-syndrome-with-highest-risk-ret-mutation
#4
A Bennaceur-Griscelli, J Hadoux, O Féraud, P Opolon, D Divers, E Gobbo, M Schlumberger, F Griscelli, A G Turhan
Multiple Endocrine Neoplasia Type 2B (MEN2B) is a cancer-predisposing syndrome that affects patients with germline RET mutations. The clinical spectrum of the syndrome includes medullary thyroid carcinoma (MTC) and pheochromocytoma. Currently, there is no satisfactory model recapitulating all the features of the disease especially at the level of stem cells. We generated induced pluripotent stem cells (iPSCs) from a patient with RET mutation at codon 918 who developed pheochromocytoma and MTC. These iPSC had normal karyotype, harboured the RET(M918T) mutation and expressed pluripotency hallmarks...
August 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28924264/neurocognitive-and-behavioral-functioning-in-adolescents-with-sleep-disordered-breathing-a-population-based-dual-energy-x-ray-absorptiometry-study
#5
S S Frye, J Fernandez-Mendoza, S L Calhoun, J Gaines, M D Sawyer, F He, D Liao, A N Vgontzas, E O Bixler
BACKGROUND/OBJECTIVES: Sleep disordered breathing (SDB) has been associated with neurocognitive and behavioral problems in young children; however, this association is less studied in adolescents. Evidence suggests that obesity plays a key role in the development of SDB, although its relative association with neurobehavioral functioning remains unclear. We examined whether SDB and obesity are associated with neurocognitive and behavior problems in adolescents. SUBJECTS/METHODS: 421 adolescents (17...
September 19, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28924187/the-ipsych2012-case-cohort-sample-new-directions-for-unravelling-genetic-and-environmental-architectures-of-severe-mental-disorders
#6
C B Pedersen, J Bybjerg-Grauholm, M G Pedersen, J Grove, E Agerbo, M Bækvad-Hansen, J B Poulsen, C S Hansen, J J McGrath, T D Als, J I Goldstein, B M Neale, M J Daly, D M Hougaard, O Mors, M Nordentoft, A D Børglum, T Werge, P B Mortensen
The Integrative Psychiatric Research (iPSYCH) consortium has established a large Danish population-based Case-Cohort sample (iPSYCH2012) aimed at unravelling the genetic and environmental architecture of severe mental disorders. The iPSYCH2012 sample is nested within the entire Danish population born between 1981 and 2005, including 1 472 762 persons. This paper introduces the iPSYCH2012 sample and outlines key future research directions. Cases were identified as persons with schizophrenia (N=3540), autism (N=16 146), attention-deficit/hyperactivity disorder (N=18 726) and affective disorder (N=26 380), of which 1928 had bipolar affective disorder...
September 19, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28924183/the-associations-of-earlier-trauma-exposures-and-history-of-mental-disorders-with-ptsd-after-subsequent-traumas
#7
R C Kessler, S Aguilar-Gaxiola, J Alonso, E J Bromet, O Gureje, E G Karam, K C Koenen, S Lee, H Liu, B-E Pennell, M V Petukhova, N A Sampson, V Shahly, D J Stein, L Atwoli, G Borges, B Bunting, G de Girolamo, S F Gluzman, J M Haro, H Hinkov, N Kawakami, V Kovess-Masfety, F Navarro-Mateu, J Posada-Villa, K M Scott, A Y Shalev, M Ten Have, Y Torres, M C Viana, A M Zaslavsky
Although earlier trauma exposure is known to predict posttraumatic stress disorder (PTSD) after subsequent traumas, it is unclear whether this association is limited to cases where the earlier trauma led to PTSD. Resolution of this uncertainty has important implications for research on pretrauma vulnerability to PTSD. We examined this issue in the World Health Organization (WHO) World Mental Health (WMH) Surveys with 34 676 respondents who reported lifetime trauma exposure. One lifetime trauma was selected randomly for each respondent...
September 19, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28924173/interfacial-origin-of-the-magnetisation-suppression-of-thin-film-yttrium-iron-garnet
#8
A Mitra, O Cespedes, Q Ramasse, M Ali, S Marmion, M Ward, R M D Brydson, C J Kinane, J F K Cooper, S Langridge, B J Hickey
Yttrium iron garnet has a very high Verdet constant, is transparent in the infrared and is an insulating ferrimagnet leading to its use in optical and magneto-optical applications. Its high Q-factor has been exploited to make resonators and filters in microwave devices, but it also has the lowest magnetic damping of any known material. In this article we describe the structural and magnetic properties of single crystal thin-film YIG where the temperature dependence of the magnetisation reveals a decrease in the low temperature region...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28923942/identification-of-sialic-acid-binding-function-for-the-middle-east-respiratory-syndrome-coronavirus-spike-glycoprotein
#9
Wentao Li, Ruben J G Hulswit, Ivy Widjaja, V Stalin Raj, Ryan McBride, Wenjie Peng, W Widagdo, M Alejandra Tortorici, Brenda van Dieren, Yifei Lang, Jan W M van Lent, James C Paulson, Cornelis A M de Haan, Raoul J de Groot, Frank J M van Kuppeveld, Bart L Haagmans, Berend-Jan Bosch
Middle East respiratory syndrome coronavirus (MERS-CoV) targets the epithelial cells of the respiratory tract both in humans and in its natural host, the dromedary camel. Virion attachment to host cells is mediated by 20-nm-long homotrimers of spike envelope protein S. The N-terminal subunit of each S protomer, called S1, folds into four distinct domains designated S1(A) through S1(D) Binding of MERS-CoV to the cell surface entry receptor dipeptidyl peptidase 4 (DPP4) occurs via S1(B) We now demonstrate that in addition to DPP4, MERS-CoV binds to sialic acid (Sia)...
September 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28923938/benefits-and-risks-of-diversification-for-individual-fishers
#10
Sean C Anderson, Eric J Ward, Andrew O Shelton, Milo D Adkison, Anne H Beaudreau, Richard E Brenner, Alan C Haynie, Jennifer C Shriver, Jordan T Watson, Benjamin C Williams
Individuals relying on natural resource extraction for their livelihood face high income variability driven by a mix of environmental, biological, management, and economic factors. Key to managing these industries is identifying how regulatory actions and individual behavior affect income variability, financial risk, and, by extension, the economic stability and the sustainable use of natural resources. In commercial fisheries, communities and vessels fishing a greater diversity of species have less revenue variability than those fishing fewer species...
September 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28923911/how-ribosomes-translate-cancer
#11
REVIEW
Sergey O Sulima, Isabel J F Hofman, Kim De Keersmaecker, Jonathan D Dinman
A wealth of novel findings, including congenital ribosomal mutations in ribosomopathies and somatic ribosomal mutations in various cancers, have significantly increased our understanding of the relevance of ribosomes in oncogenesis. Here, we explore the growing list of mechanisms by which the ribosome is involved in carcinogenesis-from the hijacking of ribosomes by oncogenic factors and dysregulated translational control, to the effects of mutations in ribosomal components on cellular metabolism. Of clinical importance, the recent success of RNA polymerase inhibitors highlights the dependence on "onco-ribosomes" as an Achilles' heel of cancer cells and a promising target for further therapeutic intervention...
September 18, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28923861/mct1-inhibitor-azd3965-increases-mitochondrial-metabolism-facilitating-combination-therapy-and-non-invasive-magnetic-resonance-spectroscopy
#12
Mounia Beloueche-Babari, Slawomir Wantuch, Teresa Casals Galobart, Markela Koniordou, Harold G Parkes, Vaitha Arunan, Yuen-Li Chung, Thomas R Eykyn, Paul D Smith, Martin O Leach
Monocarboxylate transporters (MCT) modulate tumor cell metabolism and offer promising therapeutic targets for cancer treatment. Understanding the impact of MCT blockade on tumor cell metabolism may help develop combination strategies or identify pharmacodynamic biomarkers to support the clinical development of MCT inhibitors now in clinical trials. In this study, we assessed the impact of the MCT1 inhibitor AZD3965 on cancer cell metabolism in vitro and in vivo. Exposing human lymphoma and colon carcinoma cells to AZD3965 increased MCT4-dependent accumulation of intracellular lactate, inhibiting monocarboxylate influx and efflux...
September 18, 2017: Cancer Research
https://www.readbyqxmd.com/read/28923728/natural-variation-of-selenium-in-brazil-nuts-and-soils-from-the-amazon-region
#13
E C Silva Junior, L H O Wadt, K E Silva, R M B Lima, K D Batista, M C Guedes, G S Carvalho, T S Carvalho, A R Reis, G Lopes, L R G Guilherme
Brazil nut tree (Bertholletia excelsa) is native of the Amazon rainforest. Brazil nuts are consumed worldwide and are known as the richest food source of selenium (Se). Yet, the reasoning for such Se contents is not well stablished. We evaluated the variation in Se concentration of Brazil nuts from Brazilian Amazon basin, as well as soil properties, including total Se concentration, of the soils sampled directly underneath the trees crown, aiming to investigate which soil properties influence Se accumulation in the nuts...
September 4, 2017: Chemosphere
https://www.readbyqxmd.com/read/28923475/chemical-and-nano-mineralogical-study-for-determining-potential-uses-of-legal-colombian-gold-mine-sludge-experimental-evidence
#14
Nazly E Sánchez-Peña, José L Narváez-Semanate, Daniela Pabón-Patiño, Javier E Fernández-Mera, Marcos L S Oliveira, Kátia da Boit, Bernardo F Tutikian, Tito J Crissien, Diana C Pinto, Iván D Serrano, Claudia I Ayala, Ana L Duarte, José D Ruiz, Luis F O Silva
The present study is focused on the chemical and nano-mineralogical characterization of sludge from gold mine activities, in order to put forward diverse solution alternatives, where lack of knowledge has been found. The sample was collected from "La Estrella" mine of Suarez, located in Department of Cauca, south-west Colombia. The sludge micro-structure and chemical composition were analyzed using a high resolution transmission electron microscopy (HR-TEM) equipped with a dispersive X-ray detector (EDS). X-ray diffraction technique was employed to identify the mineralogical phases present in the sludge...
August 26, 2017: Chemosphere
https://www.readbyqxmd.com/read/28923377/clinical-and-analytical-evaluation-of-the-new-aptima-mycoplasma-genitalium-assay-with-data-on-m-genitalium-prevalence-and-antimicrobial-resistance-in-m-genitalium-in-denmark-norway-and-sweden-in-2016
#15
M Unemo, K Salado-Rasmussen, M Hansen, A O Olsen, M Falk, D Golparian, M Aasterød, J Ringlander, C Steczkó Nilsson, M Sundqvist, K Schønning, H Moi, H Westh, J S Jensen
OBJECTIVES: Mycoplasma genitalium (MG) causes urethritis and cervicitis, potentially causing reproductive complications. Resistance in MG to first-line (azithromycin) and second-line (moxifloxacin) treatment has increased. We examined the clinical and analytical performance of the new CE/IVD Aptima Mycoplasma genitalium assay (CE/IVD AMG; Hologic); the prevalence of MG, Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG); and MG resistance to azithromycin and moxifloxacin in Denmark, Norway and Sweden in 2016...
September 15, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28923322/cycloartane-type-triterpene-glycosides-anopanins-a-c-with-monoacyldigalactosylglycerols-from-anodendron-paniculatum
#16
Viet Duc Ho, Thi Nhu Hanh Hoang, Quoc Hung Vo, Van Kiem Phan, Tuan Anh Le, Viet Ty Pham, Minh Hien Nguyen, Takeshi Kodama, Takuya Ito, Hiroyuki Morita, Ain Raal, Thi Hoai Nguyen
Three cycloartane-type triterpene glycosides (anopanins A-C), together with three known monoacyldigalactosylglycerols gingerglycolipids A-C and (2S)-1-O-palmitoyl-3-O-[α-d-galactopyranosyl-(1→6)-β-d-galactopyranosyl]-sn-glycerol, were isolated from the aerial parts of Anodendron paniculatum collected in Viet Nam. The chemical structures of the present compounds were elucidated by means of 1D and 2D NMR and HRESIMS spectroscopy, and by comparing to the reported data in the literature. These compounds did not show significant growth inhibitory activities (IC50 > 100 μg/mL) against the tested cancer cell lines LU-1 (lung adenocarcinoma), KB (epidermoid carcinoma), Hep-G2 (hepatoma cancer), MKN-7 (stomach cancer), and SW-480 (colon adenocarcinoma)...
September 15, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28923282/association-between-abo-blood-type-and-live-birth-outcomes-in-single-embryo-transfer-cycles
#17
Nigel Pereira, Hency H Patel, Logan D Stone, Paul J Christos, Rony T Elias, Steven D Spandorfer, Zev Rosenwaks
OBJECTIVE: To investigate the association between ABO blood type and live-birth outcomes in patients undergoing IVF with day 5 single embryo transfer (SET). DESIGN: Retrospective cohort study. SETTING: University-affiliated center. PATIENT(S): Normal responders, <40 years old, undergoing their first IVF cycle with fresh SET. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Live-birth rate was the primary outcome...
September 15, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28923103/moderate-sensitivity-and-high-specificity-of-emergency-department-administrative-data-for-transient-ischemic-attacks
#18
Amy Y X Yu, Hude Quan, Andrew McRae, Gabrielle O Wagner, Michael D Hill, Shelagh B Coutts
BACKGROUND: Validation of administrative data case definitions is key for accurate passive surveillance of disease. Transient ischemic attack (TIA) is a condition primarily managed in the emergency department. However, prior validation studies have focused on data after inpatient hospitalization. We aimed to determine the validity of the Canadian 10th International Classification of Diseases (ICD-10-CA) codes for TIA in the national ambulatory administrative database. METHODS: We performed a diagnostic accuracy study of four ICD-10-CA case definition algorithms for TIA in the emergency department setting...
September 18, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28922956/dmts-is-an-effective-treatment-in-both-inhalation-and-injection-models-for-cyanide-poisoning-using-unanesthetized-mice
#19
Susan M DeLeon, Jason D Downey, Diane M Hildenberger, Melissa O Rhoomes, Lamont Booker, Gary A Rockwood, Kelly A Basi
CONTEXT: Cyanide (CN) is a metabolic poison, halting ATP synthesis by inhibiting complex IV of the electron transport chain. If exposed at high enough concentrations, humans and most animals can die within minutes. Because time is a crucial factor in survival of CN poisoning, a rapidly bioavailable, nontoxic, easy to administer CN medical countermeasure could improve morbidity/mortality in a mass CN exposure scenario. The most likely route of exposure to CN is via inhalation. OBJECTIVE: This study examined the efficacy of a new formulation for dimethyl trisulfide (DMTS), a countermeasure which has shown promise as a treatment for CN poisoning, using both inhalation and injection models of CN exposure...
September 19, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28922899/the-current-status-of-the-distribution-range-of-the-western-pine-beetle-dendroctonus-brevicomis-curculionidae-solytinae-in-northern-mexico
#20
O Valerio-Mendoza, F Armendáriz-Toledano, G Cuéllar-Rodríguez, José F Negrón, G Zúñiga
The distribution range of the western pine beetle Dendroctonus brevicomis LeConte (Coleoptera: Curculionidae) is supported only by scattered records in the northern parts of Mexico, suggesting that its populations may be marginal and rare in this region. In this study, we review the geographical distribution of D. brevicomis in northern Mexico and perform a geometric morphometric analysis of seminal rod shape to evaluate its reliability for identifying this species with respect to other members of the Dendroctonus frontalis Zimmermann (Coleoptera: Curculionidae) complex...
September 1, 2017: Journal of Insect Science
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