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JOURNAL ARTICLE
Toralf Melsom, Norvik Jon Viljar, Inger Therese Enoksen, Vidar Stefansson, Ulla Dorte Mathisen, Ole Martin Fuskevåg, Trond G Jenssen, Marit D Solbu, Bjørn O Eriksen
No abstract text is available yet for this article.
April 23, 2024: Journal of the American Society of Nephrology: JASN
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JOURNAL ARTICLE
Soo Heon Kwak, Ryan B Hernandez-Cancela, Daniel A DiCorpo, David E Condon, Jordi Merino, Peitao Wu, Jennifer A Brody, Jie Yao, Xiuqing Guo, Fariba Ahmadizar, Mariah Meyer, Murat Sincan, Josep M Mercader, Sujin Lee, Jeffrey Haessler, Ha My T Vy, Zhaotong Lin, Nicole D Armstrong, Shaopeng Gu, Noah L Tsao, Leslie A Lange, Ningyuan Wang, Kerri L Wiggins, Stella Trompet, Simin Liu, Ruth J F Loos, Renae Judy, Philip H Schroeder, Natalie R Hasbani, Maxime M Bos, Alanna C Morrison, Rebecca D Jackson, Alexander P Reiner, JoAnn E Manson, Ninad S Chaudhary, Lynn K Carmichael, Yii-Der Ida Chen, Kent D Taylor, Mohsen Ghanbari, Joyce van Meurs, Achilleas N Pitsillides, Bruce M Psaty, Raymond Noordam, Ron Do, Kyong Soo Park, J Wouter Jukema, Maryam Kavousi, Adolfo Correa, Stephen S Rich, Scott M Damrauer, Catherine Hajek, Nam H Cho, Marguerite R Irvin, James S Pankow, Girish N Nadkarni, Robert Sladek, Mark O Goodarzi, Jose C Florez, Daniel I Chasman, Susan R Heckbert, Charles Kooperberg, Josée Dupuis, Rajeev Malhotra, Paul S de Vries, Ching-Ti Liu, Jerome I Rotter, James B Meigs
OBJECTIVE: To identify genetic risk factors for incident cardiovascular disease (CVD) among people with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: We conducted a multiancestry time-to-event genome-wide association study for incident CVD among people with T2D. We also tested 204 known coronary artery disease (CAD) variants for association with incident CVD. RESULTS: Among 49,230 participants with T2D, 8,956 had incident CVD events (event rate 18...
April 23, 2024: Diabetes Care
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JOURNAL ARTICLE
Alexandra Schäfer, Andrea Marzi, Wakako Furuyama, Nicholas J Catanzaro, Cameron Nguyen, Elaine Haddock, Friederike Feldmann, Kimberly Meade-White, Tina Thomas, Miranda L Hubbard, Kendra L Gully, Sarah R Leist, Pablo Hock, Timothy A Bell, Gabriela E De la Cruz, Bentley R Midkiff, David R Martinez, Ginger D Shaw, Darla R Miller, Michael J Vernon, Rachel L Graham, Dale O Cowley, Stephanie A Montgomery, Klaus Schughart, Fernando Pardo Manuel de Villena, Gregory K Wilkerson, Martin T Ferris, Heinz Feldmann, Ralph S Baric
Ebola virus (EBOV), a major global health concern, causes severe, often fatal EBOV disease (EVD) in humans. Host genetic variation plays a critical role, yet the identity of host susceptibility loci in mammals remains unknown. Using genetic reference populations, we generate an F2 mapping cohort to identify host susceptibility loci that regulate EVD. While disease-resistant mice display minimal pathogenesis, susceptible mice display severe liver pathology consistent with EVD-like disease and transcriptional signatures associated with inflammatory and liver metabolic processes...
April 21, 2024: Cell Reports
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JOURNAL ARTICLE
Georgia M Wong, Ashley McCray, Kara Hom, Saige Teti, Nathan T Cohen, William D Gaillard, Chima O Oluigbo
INTRODUCTION: Stereoelectroencephalography (SEEG) is valuable for delineating the seizure onset zone (SOZ) in pharmacoresistant epilepsy when non-invasive presurgical techniques are inconclusive. Secondary epilepsy surgery after initial failure is challenging and there is limited research on SEEG following failed epilepsy surgery in children. OBJECTIVE: The objective of this manuscript is to present the outcomes of children who underwent SEEG after failed epilepsy surgery...
April 23, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
#5
JOURNAL ARTICLE
Maksym Seredyuk, Kateryna Znovjyak, Francisco Javier Valverde-Muñoz, M Carmen Muñoz, Igor O Fritsky, José Antonio Real
Octahedrally coordinated spin crossover (SCO) FeII complexes represent an important class of switchable molecular materials. This study presents the synthesis and characterisation of a novel complex, [FeII (ppt-2Fph)2 ]0 ·2MeOH, where ppt-2Fph is a new asymmetric ionogenic tridentate planar ligand 2-(5-(2-fluorophenyl)-4 H -1,2,4-triazol-3-yl)-6-(1 H -pyrazol-1-yl)pyridine. The complex exhibits a hysteretic thermally induced SCO transition at 285 K on cooling and at 293 K on heating, as well as light induced excited spin state trapping (LIESST) at lower temperatures with a relaxation T (LIESST) temperature of 73 K...
April 23, 2024: Dalton Transactions: An International Journal of Inorganic Chemistry
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JOURNAL ARTICLE
Josué Rodríguez-Ramos, Carrie D Nicora, Samuel O Purvine, Mikayla A Borton, Bridget B McGivern, David W Hoyt, Mary S Lipton, Kelly C Wrighton
Rivers are critical ecosystems that impact global biogeochemical cycles. Nonetheless, a mechanistic understanding of river microbial metabolisms and their influences on geochemistry is lacking. Here, we announce metaproteomes of river sediments that are paired with metagenomes and metabolites, enabling an understanding of the microbial underpinnings of river respiration.
April 23, 2024: Microbiology Resource Announcements
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JOURNAL ARTICLE
Marcin K Dziuba, Kristina M McIntire, Kensuke Seto, Elizabeth S Davenport, Mary A Rogalski, Camden D Gowler, Emma Baird, Megan Vaandrager, Cristian Huerta, Riley Jaye, Fiona E Corcoran, Alicia Withrow, Steven Ahrendt, Asaf Salamov, Matt Nolan, Sravanthi Tejomurthula, Kerrie Barry, Igor V Grigoriev, Timothy Y James, Meghan A Duffy
UNLABELLED: The impacts of microsporidia on host individuals are frequently subtle and can be context dependent. A key example of the latter comes from a recently discovered microsporidian symbiont of Daphnia , the net impact of which was found to shift from negative to positive based on environmental context. Given this, we hypothesized low baseline virulence of the microsporidian; here, we investigated the impact of infection on hosts in controlled conditions and the absence of other stressors...
April 23, 2024: MBio
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JOURNAL ARTICLE
Eugen F Mesaros, Benjamin J Dugan, Min Gao, Muhammad Sheraz, Kayleigh McGovern-Gooch, Fran Xu, Kristi Yi Fan, Duyan Nguyen, Steven G Kultgen, Aaron Lindstrom, Kim Stever, Breanna Tercero, Randall J Binder, Fei Liu, Holly M Micolochick Steuer, Nagraj Mani, Troy O Harasym, Emily P Thi, Andrea Cuconati, Bruce D Dorsey, Andrew G Cole, Angela M Lam, Michael J Sofia
The recent COVID-19 pandemic underscored the limitations of currently available direct-acting antiviral treatments against acute respiratory RNA-viral infections and stimulated major research initiatives targeting anticoronavirus agents. Two novel nsp5 protease (MPro) inhibitors have been approved, nirmatrelvir and ensitrelvir, along with two existing nucleos(t)ide analogues repurposed as nsp12 polymerase inhibitors, remdesivir and molnupiravir, but a need still exists for therapies with improved potency and systemic exposure with oral dosing, better metabolic stability, and reduced resistance and toxicity risks...
April 23, 2024: ACS Infectious Diseases
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JOURNAL ARTICLE
N Kumar, N V Surovtsev, P A Yunin, D V Ishchenko, I A Milekhin, S P Lebedev, A A Lebedev, O E Tereshchenko
BSTS epitaxial thin film topological insulators were grown using the MBE technique on two different types of substrates i.e. , Si (111) and SiC/graphene with Bi0.7 Sb1.6 Te1.8 Se0.9 and Bi0.9 Sb1.5 Te1.8 Se1.1 , respectively. The crystallographic properties of BSTS films were investigated via X-ray diffraction, which showed the strongest reflections from the (0 0 l ) facets corresponding to the rhombohedral phase. Superior epitaxial growth, homogeneous thickness, smooth surfaces, and larger unit cell parameters were observed for the films grown on the Si substrate...
April 23, 2024: Physical Chemistry Chemical Physics: PCCP
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JOURNAL ARTICLE
Joseph L Pegler, John W Patrick, Benjamin McDermott, Anthony Brown, Jackson M J Oultram, Christopher P L Grof, John M Ward
Sugar transport proteins (STPs) are high-affinity H+ -coupled hexose symporters. Recently, the contribution of STP13 to bacterial and fungal pathogen resistance across multiple plant species has garnered significant interest. Quantitative PCR analysis of source leaves, developing embryos, and seed coats of Phaseolus vulgaris L . (common bean) revealed that PvSTP13.1 was expressed in source leaves and seed coats throughout seed development. In contrast, PvSTP13.1 transcripts were detected at exceedingly low levels in developing embryos...
April 2024: Plant Direct
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Luke Mugge, Danielle D Dang, Mateo Ziu, Andrew Fanous
Intra-operative navigation has revolutionized spinal instrumentation. The O-arm (a mobile X-ray system; Medtronic, Minneapolis, MN) is uniquely capable of enabling visualization of the spine in axial planes. The application of this technology is wide yet underutilized in terms of its capacity to image spinal vascular anatomy. We completed a retrospective chart review of the following case studies. A 24-year-old neurologically intact female presented with a Jefferson fracture without vertebral artery dissection after a motor vehicle accident...
March 2024: Curēus
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REVIEW
Anisha N Patel, Laura Lander, Jyoti Ahuja, James Bulman, James K H Lum, Julian O D Pople, Alastair Hales, Yatish Patel, Jacqueline S Edge
Net zero targets have resulted in a drive to decarbonise the transport sector worldwide through electrification. This has, in turn, led to an exponentially growing battery market and, conversely, increasing attention on how we can reduce the environmental impact of batteries and promote a more efficient circular economy to achieve real net zero. As these batteries reach the end of their first life, challenges arise as to how to collect and process them, in order to maximise their economical use before finally being recycled...
2024: Frontiers in Chemistry
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JOURNAL ARTICLE
A Korneev I, I Apolikhin O, Yu Babenko A, V Bogo-Lyubov S, A Bozhedomov V, V Vinogradov I, A Gazimiev M, I Gamidov S, A Efremov E, A Epanchint-Seva E, B Zhukov O, A Kamalov A, A Kinunen A, I Kogan M, S Korsak V, S Krasnyak S, V Moiseeva I, I Ovchinnikov R, S Petrishchev V, S Rogozin D, T Savzikhanov R, B Chernykh V, V Shurygina O
A review of controversial issues about the terminology on male infertility and reproductive function, which is currently used, as well as proposals for updating clinical guidelines for the diagnosis and treatment of male infertility and men in infertile couples are presented in the article. An algorithm is described, the elements of which ensure referral of patients based on the possibility and timing of restoration of reproductive function, taking into account the reproductive health of a woman, as well as increasing the likelihood of successful treatment aimed at the birth of a healthy child...
March 2024: Urologii︠a︡
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JOURNAL ARTICLE
V Protoshchak V, N Orlov D, V Paronnikov M, G Karpushchenko E
AIM: To improve the results of treatment of patients with urolithiasis who underwent endoscopic interventions using a ureteral access sheath (UAS) by developing a predictive model of ureteral dilatation without pre-stenting. MATERIALS AND METHODS: A total of 180 patients with kidney stones up to 20 mm were included in the study. They were divided into two groups: in the group 1 (n=79) UAS of 12/14 Ch was used, while in group II (n=101) UAS of 10/12 Ch was inserted...
March 2024: Urologii︠a︡
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JOURNAL ARTICLE
E Karasev A, I Bresso T, D Markova O, R Kasyan G, Yu Pushkar D
AIM: To assess the quality of life of patients with interstitial cystitis (IC) and to study effective options used to control symptoms on outpatient basis. MATERIALS AND METHODS: The results of a descriptive prospective cross-sectional cohort study are presented. The medical charts of patients who were treated in the City Clinical Hospital named after Spasokukotsky from 2021 to 2023 were analyzed. Eighty inpatient medical charts of various patients with a final diagnosis of IC with Hunner's lesion were identified...
March 2024: Urologii︠a︡
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JOURNAL ARTICLE
M Dunowska, G D More, P J Biggs, N J Cave
AIMS: To isolate canine respiratory coronavirus (CRCoV) and canine pneumovirus (CnPnV) in cell culture and to compare partial genomic sequences of CRCoV and CnPnV from New Zealand with those from other countries. METHODS: Oropharyngeal swab samples from dogs affected by canine infectious respiratory disease syndrome that were positive for CnPnV (n = 15) or CRCoV (n = 1) by virus-specific reverse transcriptase quantitative PCR (RT-qPCR) in a previous study comprised the starting material...
April 22, 2024: New Zealand Veterinary Journal
#17
JOURNAL ARTICLE
Bjørn-Erik Bertelsen, Bjørg Almås, Kamilla Fjermeros, Kristin Viste, Stephanie Beate Geisler, Torill Sauer, Knut Selsås, Jürgen Geisler
PURPOSE: The aromatase inhibitor letrozole and the aromatase inactivator exemestane are two of the most pivotal cancer drugs used for endocrine treatment of ER-positive breast cancer in all phases of the disease. Although both drugs inhibit CYP19 (aromatase) and have been used for decades, a direct head-to-head, intra-patient-cross-over comparison of their ability to decrease estrogen synthesis in vivo is still lacking. METHODS: Postmenopausal breast cancer patients suitable for neoadjuvant endocrine therapy were randomized to receive either letrozole (2...
April 23, 2024: Breast Cancer Research and Treatment
#18
JOURNAL ARTICLE
V Niščáková, M Almáši, D Capková, T Kazda, O Čech, P Čudek, O Petruš, D Volavka, R Oriňaková, A S Fedorková
Due to the increasing demand for energy storage devices, the development of high-energy density batteries is very necessary. Lithium-sulfur (Li-S) batteries have gained wide interest due to their particularly high-energy density. However, even this type of battery still needs to be improved. Novel Cu(II)-based metal-organic framework STAM-1 was synthesized and applied as a composite cathode material as a sulfur host in the lithium-sulfur battery with the aim of regulating the redox kinetics of sulfur cathodes...
April 22, 2024: Scientific Reports
#19
JOURNAL ARTICLE
Pingfeng Zhang, Zheng Liu
DltB, a model member of the Membrane-Bound O-AcylTransferase (MBOAT) superfamily, plays a crucial role in D-alanylation of the lipoteichoic acid (LTA), a significant component of the cell wall of gram-positive bacteria. This process stabilizes the cell wall structure, influences bacterial virulence, and modulates the host immune response. Despite its significance, the role of DltB is not well understood. Through biochemical analysis and cryo-EM imaging, we discover that Streptococcus thermophilus DltB forms a homo-tetramer on the cell membrane...
April 22, 2024: Nature Communications
#20
JOURNAL ARTICLE
Alina K Bakunova, Ilya O Matyuta, Mikhail E Minyaev, Tatiana Y Isaikina, Konstantin M Boyko, Vladimir O Popov, Ekaterina Yu Bezsudnova
Structure-function relationships are key to understanding enzyme mechanisms, controlling enzyme activities, and designing biocatalysts. Here, we investigate the functions of arginine residues in the active sites of pyridoxal-5'-phosphate (PLP)-dependent non-canonical D-amino acid transaminases, focusing on the analysis of a transaminase from Haliscomenobacter hydrossis. Our results show that the tandem of arginine residues R28* and R90, which form the conserved R-[RK] motif in non-canonical D-amino acid transaminases, not only facilitates effective substrate binding but also regulates the catalytic properties of PLP...
April 20, 2024: Archives of Biochemistry and Biophysics
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