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https://www.readbyqxmd.com/read/27923111/evaluation-of-a-pilot-school-based-physical-activity-challenge-for-primary-students
#1
E Passmore, C Donato-Hunt, L Maher, R Havrlant, K Hennessey, A Milat, L Farrell
Issue addressed: Physical inactivity and sedentary behaviour among children are growing public health concerns. The Culture Health Communities Activity Challenge (hereafter known as the Challenge) is a school-based pedometer program in which classes compete to achieve the highest class average daily steps in an 8-week period. The Challenge aims to encourage physical activity in primary school students, with a focus on engaging Aboriginal students. The program was piloted in 15 classes in New South Wales in 2014...
December 2, 2016: Health Promotion Journal of Australia
https://www.readbyqxmd.com/read/27922448/the-second-randomised-evaluation-of-the-effectiveness-cost-effectiveness-and-acceptability-of-computerised-therapy-reeact-2-trial-does-the-provision-of-telephone-support-enhance-the-effectiveness-of-computer-delivered-cognitive-behaviour-therapy-a-randomised
#2
Sally Brabyn, Ricardo Araya, Michael Barkham, Peter Bower, Cindy Cooper, Ana Duarte, David Kessler, Sarah Knowles, Karina Lovell, Elizabeth Littlewood, Richard Mattock, Stephen Palmer, Jodi Pervin, David Richards, Debbie Tallon, David White, Simon Walker, Gillian Worthy, Simon Gilbody
BACKGROUND: Computerised cognitive behaviour therapy (cCBT) is an efficient form of therapy potentially improving access to psychological care. Indirect evidence suggests that the uptake and effectiveness of cCBT can be increased if facilitated by telephone, but this is not routinely offered in the NHS. OBJECTIVES: To compare the clinical effectiveness and cost-effectiveness of telephone-facilitated free-to-use cCBT [e.g. MoodGYM (National Institute for Mental Health Research, Australian National University, Canberra, ACT, Australia)] with minimally supported cCBT...
November 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27922028/a-randomized-double-blind-placebo-controlled-trial-to-examine-the-effectiveness-of-lubiprostone-on-constipation-symptoms-and-colon-transit-time-in-diabetic-patients
#3
Jennifer Christie, Sagar Shroff, Nikrad Shahnavaz, Latoya A Carter, Melanie S Harrison, Karan A Dietz-Lindo, John Hanfelt, Shanthi Srinivasan
OBJECTIVES: Constipation is the most common GI symptom in patients with diabetes mellitus (DM). Importantly, patients with constipation have lower health-related quality of life than those without constipation. Effective therapies for constipation are limited and there is a paucity of data evaluating the treatment of constipation in diabetics. METHODS: Diabetic patients with chronic idiopathic constipation (CIC) as defined by Rome III criteria were recruited from outpatient clinics at a tertiary-care center and a Veterans Administration Hospital...
December 6, 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27921992/the-hubble-trial-haemorrhoidal-artery-ligation-hal-versus-rubber-band-ligation-rbl-for-symptomatic-second-and-third-degree-haemorrhoids-a-multicentre-randomised-controlled-trial-and-health-economic-evaluation
#4
Steven Brown, Jim Tiernan, Katie Biggs, Daniel Hind, Neil Shephard, Mike Bradburn, Allan Wailoo, Abualbishr Alshreef, Lizzie Swaby, Angus Watson, Simon Radley, Oliver Jones, Paul Skaife, Anil Agarwal, Pasquale Giordano, Marc Lamah, Mark Cartmell, Justin Davies, Omar Faiz, Karen Nugent, Andrew Clarke, Angus MacDonald, Phillip Conaghan, Paul Ziprin, Rohit Makhija
BACKGROUND: Optimal surgical intervention for low-grade haemorrhoids is unknown. Rubber band ligation (RBL) is probably the most common intervention. Haemorrhoidal artery ligation (HAL) is a novel alternative that may be more efficacious. OBJECTIVE: The comparison of HAL with RBL for the treatment of grade II/III haemorrhoids. DESIGN: A multicentre, parallel-group randomised controlled trial. PERSPECTIVE: UK NHS and Personal Social Services...
November 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27921256/impact-of-bridging-income-generation-with-group-integrated-care-bigpic-on-hypertension-and-diabetes-in-rural-western-kenya
#5
Sonak D Pastakia, Simon M Manyara, Rajesh Vedanthan, Jemima H Kamano, Diana Menya, Benjamin Andama, Cleophas Chesoli, Jeremiah Laktabai
BACKGROUND: Rural settings in Sub-Saharan Africa (SSA) consistently report low participation in non-communicable disease (NCD) treatment programs and poor outcomes. OBJECTIVE: The objective of this study is to assess the impact of the implementation of a patient-centered rural NCD care delivery model called Bridging Income Generation through grouP Integrated Care (BIGPIC). DESIGN: The study prospectively tracked participation and health outcomes for participants in a screening event and compared linkage frequencies to a historical comparison group...
December 5, 2016: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/27920540/treatment-cost-of-narcolepsy-with-cataplexy-in-central-europe
#6
Petra Maresova, Michal Novotny, Blanka Klímová, Kamil Kuča
BACKGROUND: Narcolepsy is a lifelong, rare neurological sleep disorder characterized by chronic, excessive attacks of daytime sleepiness. This disease is often extremely incapacitating, interfering with every aspect of life, in work and social settings. OBJECTIVE: The purpose of this study is to specify the treatment costs of patients in Central Europe (Czech Republic), while the attention is mainly paid to the drugs that were fully or partially covered by public health insurance...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27920515/effect-of-elom-080-on-exacerbations-and-symptoms-in-copd-patients-with-a-chronic-bronchitis-phenotype-a-post-hoc-analysis-of-a-randomized-double-blind-placebo-controlled-clinical-trial
#7
Kai-Michael Beeh, Jutta Beier, Henning Candler, Thomas Wittig
BACKGROUND: Treating symptoms and preventing exacerbations are key components of chronic obstructive pulmonary disease (COPD) long-term management. Recently, a more tailored treatment approach has been proposed, in particular for two well-established clinical phenotypes, frequent exacerbators and chronic bronchitis-dominant COPD. ELOM-080 has demonstrated clinical efficacy in treating symptoms and preventing exacerbations in subjects with chronic bronchitis. However, little is known about the potential effects of ELOM-080 in COPD patients...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27920512/the-burden-of-chronic-obstructive-pulmonary-disease-associated-with-maintenance-monotherapy-in-the-uk
#8
Susan C Edwards, Sian E Fairbrother, Anna Scowcroft, Gavin Chiu, Andrew Ternouth, Brian J Lipworth
BACKGROUND: This study characterized a cohort of chronic obstructive pulmonary disease (COPD) patients on maintenance bronchodilator monotherapy for ≥6 months to establish their disease burden, measured by health care utilization. METHODS: Data were extracted from the UK Clinical Practice Research Datalink and linked to Hospital Episode Statistics. The monotherapy period spanned the first prescription of a long-acting β2-adrenergic agonist or a long-acting muscarinic antagonist until the end of the study (December 31, 2013) or until step up to dual/triple therapy, for example, addition of another long-acting bronchodilator, an inhaled corticosteroid, or both...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27920249/evaluating-the-impact-of-continuous-quality-improvement-methods-at-hospitals-in-tanzania-a-cluster-randomized-trial
#9
Yusuke Kamiya, Hisahiro Ishijma, Akiko Hagiwara, Shizu Takahashi, Henook A M Ngonyani, Eleuter Samky
OBJECTIVE: To evaluate the impact of implementing continuous quality improvement (CQI) methods on patient's experiences and satisfaction in Tanzania. DESIGN: Cluster-randomized trial, which randomly allocated district-level hospitals into treatment group and control group, was conducted. SETTING: Sixteen district-level hospitals in Kilimanjaro and Manyara regions of Tanzania. PARTICIPANTS: Outpatient exit surveys targeting totally 3292 individuals, 1688 in the treatment and 1604 in the control group, from 3 time-points between September 2011 and September 2012...
December 4, 2016: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/27919900/n-acetyl-l-cysteine-and-cysteamine-new-strategies-against-mixed-biofilms-of-non-encapsulated-streptococcus-pneumoniae-and-non-typeable-haemophilus-influenzae
#10
Mirian Domenech, Ernesto García
Acute otitis media, a polymicrobial disease of the middle ear cavity of children, is a significant public health problem worldwide. It is most frequently caused by encapsulated Streptococcus pneumoniae and non-typeable Haemophilus influenzae, although the widespread use of pneumococcal conjugate vaccines is apparently producing an increase in carriage of non-encapsulated S. pneumoniae Frequently, pneumococci and H. influenzae live together in the human nasopharynx forming a self-produced biofilm. Biofilms represent a global medical challenge since the inherent antibiotic resistance of their producers demands the use of high doses of antibiotics over prolonged periods...
December 5, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27919793/inter-rater-reliability-for-thrombolysis-in-cerebral-infarction-with-tici-2c-category
#11
Ondrej Volny, Petra Cimflova, Viktor Szeder
BACKGROUND AND PURPOSE: Thrombolysis in cerebral infarction (TICI) with 2b/3 (>50% of occluded territory/complete reperfusion) has been regarded as a successful angiographic outcome. To account for near-perfect angiographic results, the category TICI 2c (near-complete reperfusion) has been introduced. As the degree of inter-rater reliability for TICI with 2c category remains poorly studied, we strived to evaluate the agreement among stroke-treating specialists. METHODS: All consecutive patients, who underwent stent-retriever thrombectomy for acute ischemic stroke in the period between January 2014 and April 2016 at the Department of Neurointerventional Radiology, were analyzed...
December 2, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27919689/seasonal-dynamics-of-human-retinol-status-in-mobile-pastoralists-in-chad
#12
Lisa Crump, Mahamat Béchir, Bongo Naré Richard Ngandolo, Doumagoum Moto Daugla, Jan Hattendorf, Jakob Zinsstag
Vitamin A deficiency is a prevalent public health problem in Africa and South-East Asia, although national population based surveys are lacking in many countries. This study investigated seasonal variation of human retinol concentrations in Chadian mobile pastoralists to identify critical time periods for interventions addressing vitamin A deficiency. The repeated cross-sectional study design used convenience sampling during three seasons to include 327 Fulani, Gorane and Arab adult mobile pastoralists in nine camps in the Lake Chad area...
December 2, 2016: Acta Tropica
https://www.readbyqxmd.com/read/27919449/nonsteroidal-anti-inflammatory-drugs-may-affect-cytokine-response-and-benefit-healing-of-combat-related-extremity-wounds
#13
Felipe A Lisboa, Matthew J Bradley, Matthew T Hueman, Seth A Schobel, Beverly J Gaucher, Edda L Styrmisdottir, Benjamin K Potter, Jonathan A Forsberg, Eric A Elster
BACKGROUND: After adequate operative debridement and antimicrobial therapies, combat-related extremity wounds that either heal or fail are both associated with a distinct inflammatory response. Short-term use of nonsteroidal anti-inflammatory drugs in postoperative pain management may affect this response and, by consequence, the healing potential of these wounds. We investigated whether patients treated with nonsteroidal anti-inflammatory drugs had a distinct inflammatory response; different rates of critical colonization, defined as >10(5) colony forming units on quantitative bacteriology; and healing potential...
December 2, 2016: Surgery
https://www.readbyqxmd.com/read/27919209/evaluation-of-echocardiographic-abnormalities-in-hiv-positive-patients-treated-with-antiretroviral-medications
#14
Sina Moradmand Badie, Mehrnaz Rasoulinejad, Mohammadreza Salehi, Hamid Emadi Kochak, SeyedAhmad SeyedAlinaghi, Seyed Ali Dehghan Manshadi, Fatemeh Jahanjo Amin Abad, Banafsheh Moradmand Badie
BACKGROUND: Echocardiography is a reliable means for the diagnosis of functional and valvular diseases of the heart in HIV positive and HIV negative patients. The current study was to evaluate echocardiographic abnormalities in HIV positive patients under an antiretroviral therapy (ART) program in Tehran, Imam Khomeini Hospital, Iran. METHODS: This is a descriptive cross-sectional study, conducted among 231 HIV positive patients under ART. All HIV positive patients including 150 men (65%) and 81 women (35%) (mean age of 41 years) were assessed by trans-thoracic echocardiography (TTE) in Imam Khomeini Hospital, over the period from 2013 to 2014...
December 5, 2016: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/27918784/association-of-long-term-low-intensity-smoking-with-all-cause-and-cause-specific-mortality-in-the-national-institutes-of-health-aarp-diet-and-health-study
#15
Maki Inoue-Choi, Linda M Liao, Carolyn Reyes-Guzman, Patricia Hartge, Neil Caporaso, Neal D Freedman
Importance: A growing proportion of US smokers now smoke fewer than 10 cigarettes per day (CPD), and that proportion will likely rise in the future. The health effects of smoking only a few CPD over one's lifetime are less understood than are the effects of heavier smoking, although many smokers believe that their level is modest. Objective: To evaluate the associations of long-term smoking of fewer than 1 or 1 to 10 CPD (low intensity) with all-cause and cause-specific mortality compared with never smoking cigarettes...
December 5, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27918190/quasi-experimental-evaluation-of-the-impact-of-a-cognitive-behavioral-pretreatment-intervention-for-veterans-seeking-psychotherapy
#16
Rebecca Lusk, Mark Lyubkin, Stephen T Chermack, Michelle L Sanborn, Nicholas W Bowersox
Pretreatment interventions have documented efficacy for reducing initial therapy refusal and early therapy departure. However, these interventions have not been well-studied in diagnostically diverse patient populations or within Veterans Affairs (VA) health care settings. We designed a manualized 4-session group cognitive-behavioral therapy-based pretreatment intervention (PTI) for a diagnostically diverse population of Veterans referred for psychotherapy in a general mental health clinic (MHC) in a large VA hospital...
December 2016: Psychotherapy
https://www.readbyqxmd.com/read/27917324/expanded-access-of-investigational-drugs-the-experience-of-the-center-of-drug-evaluation-and-research-over-a-10-year-period
#17
Jonathan P Jarow, Steven Lemery, Kevin Bugin, Sean Khozin, Richard Moscicki
BACKGROUND: The purpose of this study was to describe the experience of the Center of Drug Evaluation and Research (CDER) with expanded access of investigational drugs. METHODS: Multiple searches of CDER's document tracking system were performed to identify the number, type, and indication for all expanded access requests over the 10-year time period of January 2005 through December 2014. An additional search was performed to identify all active commercial investigational drug development programs during that time period and whether or not the clinical program was placed on hold...
November 2016: Therapeutic Innovation & Regulatory Science
https://www.readbyqxmd.com/read/27917307/clinical-and-cost-impact-analysis-of-a-novel-prognostic-test-for-early-detection-of-preterm-birth
#18
Aaron B Caughey, John A F Zupancic, James M Greenberg, Susan S Garfield, Stephen F Thung, Jay D Iams
Objective The objective of this study was to evaluate the potential impact to the U.S. health care system by adopting a novel test that identifies women at risk for spontaneous preterm birth. Methods A decision-analytic model was developed to assess clinical and cost outcomes over a 1-year period. The use of a prognostic test to predict spontaneous preterm birth in a hypothetical population of women reflective of the U.S. population (predictive arm) was compared with the current baseline rate of spontaneous preterm birth and associated infant morbidity and mortality (baseline care arm)...
October 2016: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/27916433/assessment-of-cost-sharing-in-the-pima-county-marketplace
#19
Nicholas B Jennings, Howard J Eng
The Patient Protection and Affordable Care Act established health insurance marketplaces to allow consumers to make educated decisions about their health care coverage. During the first open enrollment period in 2013, the federally facilitated marketplace in Pima County, Arizona listed 119 plans, making it one of the most competitive markets in the country. This study compares these plans based on differences in consumer cost sharing, including deductibles, co-pays and premiums. Consumer costs were reviewed using specific cases including a normal delivery pregnancy, the management of Type II Diabetes, and the utilization of specialty drugs to treat Hepatitis C...
November 8, 2016: Health Policy
https://www.readbyqxmd.com/read/27916411/beyond-expectations-post-implementation-data-shows-rotavirus-vaccination-is-likely-cost-saving-in-australia
#20
J F Reyes, J G Wood, P Beutels, K Macartney, P McIntyre, R Menzies, N Mealing, A T Newall
BACKGROUND: Universal vaccination against rotavirus was included in the funded Australian National Immunisation Program in July 2007. Predictive cost-effectiveness models assessed the program before introduction. METHODS: We conducted a retrospective economic evaluation of the Australian rotavirus program using national level post-implementation data on vaccine uptake, before-after measures of program impact and published estimates of excess intussusception cases...
December 1, 2016: Vaccine
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