keyword
https://read.qxmd.com/read/12029163/nucleotide-sequences-of-segments-1-3-and-4-of-the-genome-of-bombyx-mori-cypovirus-1-encoding-putative-capsid-proteins-vp1-vp3-and-vp4-respectively
#21
COMPARATIVE STUDY
Kyoji Hagiwara, Shujing Rao, Simon W Scott, Gerald R Carner
The complete nucleotide sequences of genomic segments S1, S3 and S4 from Bombyx mori cypovirus 1 (BmCPV-1) have been determined. The segments consisted of 4190, 3846 and 3262 nucleotides encoding putative proteins of 1333, 1239 and 1058 amino acids with molecular masses of approximately 148, 140 and 120 kDa (p148, p140 and p120, respectively). All segments possess a single open reading frame. Homology searches showed that all three proteins have homologies to proteins of Rice ragged stunt virus, a member of the genus Oryzavirus within the family REOVIRIDAE: Partial homologies of p140 to structural proteins in other viruses were also found...
June 2002: Journal of General Virology
https://read.qxmd.com/read/11746685/threading-structural-model-of-the-manganese-stabilizing-protein-psbo-reveals-presence-of-two-possible-beta-sandwich-domains
#22
JOURNAL ARTICLE
F Pazos, P Heredia, A Valencia, J de las Rivas
The manganese-stabilizing protein (PsbO) is an essential component of photosystem II (PSII) and is present in all oxyphotosynthetic organisms. PsbO allows correct water splitting and oxygen evolution by stabilizing the reactions driven by the manganese cluster. Despite its important role, its structure and detailed functional mechanism are still unknown. In this article we propose a structural model based on fold recognition and molecular modeling. This model has additional support from a study of the distribution of characteristics of the PsbO sequence family, such as the distribution of conserved, apolar, tree-determinants, and correlated positions...
December 1, 2001: Proteins
https://read.qxmd.com/read/11746604/amino-acid-residues-important-for-substrate-specificity-of-the-amino-acid-permeases-can1p-and-gnp1p-in-saccharomyces-cerevisiae
#23
JOURNAL ARTICLE
B Regenberg, M C Kielland-Brandt
Deletion of the general amino acid permease gene GAP1 abolishes uptake of L-citrulline in Saccharomyces cerevisiae, resulting in the inability to grow on L-citrulline as sole nitrogen source. Selection for suppressor mutants that restored growth on L-citrulline led to isolation of 21 mutations in the arginine permease gene CAN1. One similar mutation was found in the glutamine-asparagine permease gene GNP1. L-[(14)C]citrulline uptake measurements confirmed that suppressor mutations in CAN1 conferred uptake of this amino acid, while none of the mutant permeases had lost the ability to transport L-[(14)C]arginine...
November 2001: Yeast
https://read.qxmd.com/read/7497531/myelin-proteolipid-protein-induced-th1-and-th2-clones-express-tcr-with-similar-fine-specificity-for-peptide-and-cdr3-homology-despite-diverse-v-beta-usage
#24
JOURNAL ARTICLE
R C van der Veen, P J Chen, M McMillan
Myelin-specific T-helper (Th) cells which induce encephalomyelitis belong to the inflammatory Th1 subset. Th2 cells recognizing similar epitopes potentially represent specific inhibitors of encephalitogenic Th1 cells. Since the differential stimulation of antigen-specific Th2 cells may be important in the regulation of autoimmune inflammatory disorders, we have examined the fine specificity of a Th1 and a Th2 clone, induced by immunization of SJL mice with native proteolipid protein (PLP) and specific for the PLP 139-151 sequence...
December 1995: Cellular Immunology
https://read.qxmd.com/read/2997384/humoral-immune-response-to-hsv-1-and-hsv-2-viral-proteins-in-patients-with-primary-genital-herpes
#25
JOURNAL ARTICLE
R Ashley, J Benedetti, L Corey
The humoral immune response to HSV-1 and HSV-2 proteins was examined in patients with primary first-episode genital herpes. Ten patients had culture-proven HSV-1 infections, 37 had HSV-2 infections, and all were seronegative to HSV proteins before developing their infections. Development of serum antibodies to individual HSV proteins and glycoproteins was determined by immunoprecipitation of radiolabeled HSV-1- and HSV-2-infected cell proteins and subsequent gel electrophoresis. In HSV-1 patients, a sequential development of antibodies to HSV-1 proteins was observed with early appearance of antibodies to the nucleocapsid protein p148 and to glycoproteins gB and gC...
October 1985: Journal of Medical Virology
https://read.qxmd.com/read/1691762/importance-of-subtype-in-the-immune-response-to-the-pre-s-2-region-of-the-hepatitis-b-surface-antigen-i-t-cell-fine-specificity
#26
JOURNAL ARTICLE
D R Milich, J L Hughes, A McLachlan, K E Langley, G B Thornton, J E Jones
Previous studies of murine T cell recognition of the pre-S(2) region of the hepatitis B surface Ag (HBsAg) identified high (H-2b,d,q), intermediate (H-2s,k), and low to nonresponder (H-2f) haplotypes. However, these studies utilized the y subtype of HBsAg. The purpose of this study was to examine the influence of viral subtype on T cell recognition of the pre-S(2) region and to identify specific T cell recognition sites in a panel of H-2 congenic strains. Immunization with pre-S(2) containing HBsAg particles of the d and y subtypes indicated that T cell recognition of the pre-S(2) region is predominantly subtype-specific in murine strains of eight different H-2 haplotypes...
May 1, 1990: Journal of Immunology
https://read.qxmd.com/read/1330891/confirmation-of-the-localization-of-the-human-gabaa-receptor-alpha-1-subunit-gene-gabra1-to-distal-5q-by-linkage-analysis
#27
JOURNAL ARTICLE
K J Johnson, T Sander, A A Hicks, A van Marle, D Janz, M J Mullan, B P Riley, M G Darlison
The GABAA receptor is the major inhibitory neurotransmitter receptor in the mammalian brain. To date, 14 genes that encode subunits of this receptor have been identified; these appear to be scattered throughout the human genome and are under investigation as candidate loci for a number of neurological and psychiatric disorders. We report here a highly polymorphic (dC-dA)n repeat within the human alpha 1-subunit gene (GABRA1). Typing of this marker in the Centre d'Etude du Polymorphisme Humain (CEPH) panel of families confirms the previous assignment of the GABRA1 locus to the distal portion of chromosome 5q by demonstrating linkage to the markers CRI-L45 (D5S61) (Zmax = 11...
November 1992: Genomics
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