Di Cui, Aihua Deng, Hua Bai, Zhao Yang, Yong Liang, Zhe Liu, Qidi Qiu, Laiyou Wang, Shuwen Liu, Yun Zhang, Yi Shi, Jianxun Qi, Tingyi Wen
3-deoxy-d-arabino-heptulosonate-7-phosphate synthase (DAHPS) is responsible for the biosynthesis of essential aromatic compounds in microorganisms and plants. It plays a crucial role in the regulation of the carbon flow into the shikimate pathway. Until now, the crystal structures and regulatory mechanisms of dimeric DAHPS enzymes from type Iα subclass have not been reported. Here, we reported dimeric structures of the tyrosine-regulated DAHPS from Escherichia coli, both in its apo form and complex with the inhibitor tyrosine at 2...
April 1, 2019: Journal of Structural Biology