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Cardiac resynchronization

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https://www.readbyqxmd.com/read/28214846/circulating-mir-30d-predicts-survival-in-patients-with-acute-heart-failure
#1
Junjie Xiao, Rongrong Gao, Yihua Bei, Qiulian Zhou, Yanli Zhou, Haifeng Zhang, Mengchao Jin, Siqi Wei, Kai Wang, Xuejuan Xu, Wenming Yao, Dongjie Xu, Fang Zhou, Jingfa Jiang, Xinli Li, Saumya Das
BACKGROUND/AIMS: Identification of novel biomarkers to identify acute heart failure (AHF) patients at high risk of mortality is an area of unmet clinical need. Recently, we reported that the baseline level of circulating miR-30d was associated with left ventricular remodeling in response to cardiac resynchronization therapy in advanced chronic heart failure patients. However, the role of circulating miR-30d as a prognostic marker of survival in patients with AHF has not been explored...
February 16, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28214565/trends-and-outcomes-of-cardiac-resynchronization-therapy-upgrade-procedures-a-comparative-analysis-using-a-united-states-national-database-2003-2013
#2
Jim W Cheung, James E Ip, Steven M Markowitz, Christopher F Liu, George Thomas, Dmitriy N Feldman, Rajesh V Swaminathan, Bruce B Lerman, Luke K Kim
BACKGROUND: While outcomes after de novo CRT implantations have been reported, there are limited data on CRT upgrade procedures. OBJECTIVES: The purpose of this study to examine trends and in-hospital outcomes of patients undergoing upgrade to cardiac resynchronization therapy (CRT) procedures using a large, national inpatient database. METHODS: Using the National Inpatient Sample database, we identified all patients undergoing CRT upgrade and de novo CRT implants between 2003 and 2013...
February 15, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28213711/implantable-cardioverter-defibrillators-for-primary-prevention-in-dilated-cardiomyopathy-post-danish-an-updated-meta-analysis-and-systematic-review-of-randomized-controlled-trials
#3
Georg Wolff, Yingfeng Lin, Athanasios Karathanos, Maximilian Brockmeyer, Susanne Wolters, Bernd Nowak, Alexander Fürnkranz, Hisaki Makimoto, Malte Kelm, Volker Schulze
BACKGROUND: Sudden cardiac death (SCD) is frequent in patients with heart failure due to dilated cardiomyopathy (DCM). Implantable cardioverter/defibrillator (ICD) device therapy is currently used for primary prevention. However, publication of the DANISH trial has recently given reason for doubt, showing no significant improvement in all-cause mortality in comparison to contemporary medical therapy. METHODS: We performed a meta-analysis of all randomized controlled trials comparing ICD therapy to medical therapy (MT) for primary prevention in DCM...
February 17, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28202631/cardiac-resynchronization-therapy-upgrade-verschlimmbesserung
#4
EDITORIAL
Anoop K Shetty, Christopher A Rinaldi
No abstract text is available yet for this article.
February 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28202628/effects-of-upgrade-versus-de-novo-cardiac-resynchronization-therapy-on-clinical-response-and-long-term-survival-results-from-a-multicenter-study
#5
Mate Vamos, Julia W Erath, Zsolt Bari, Denes Vagany, Sven P Linzbach, Tatsiana Burmistrava, Carsten W Israel, Gabor Z Duray, Stefan H Hohnloser
BACKGROUND: Benefits of cardiac resynchronization therapy (CRT) on morbidity and mortality in selected patients are well known. Although the number of upgrade procedures from single- or dual-chamber devices to CRT is increasing, there are only sparse data on the outcomes of upgrade procedures compared with de novo CRT. This study aimed to evaluate clinical response and survival in patients receiving de novo versus upgrade CRT defibrillator therapy. METHODS AND RESULTS: Prospectively collected outcome data were compared in patients undergoing de novo or upgrade CRT defibrillator implantation at 3 implant centers in Germany and Hungary...
February 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28198522/cardiovascular-drug-utilization-post-implant-is-related-to-clinical-outcome-in-heart-failure-patients-receiving-cardiac-resynchronization-therapy
#6
Zoltan Bakos, Christian Reitan, Anna Werther-Evaldsson, Anders Roijer, Pyotr PLatonov, Rasmus Borgquist
BACKGROUND: In select patients with heart failure, cardiac resynchronization therapy (CRT) is the most common complementary treatment besides medical treatment. We aimed to assess the association between post CRT-implant changes in cardiovascular medication and cardiovascular mortality and heart failure hospitalization. METHODS: 211 patients on optimal medical therapy eligible for CRT were retrospectively included in this study (72 ± 7 years, 80% male, 66% left bundle branch block [LBBB], 48% dilated cardiomyopathy [DCMP]) and investigated at baseline and after 6 months ...
February 15, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28197975/research-of-predictive-factors-for-cardiac-resynchronization-therapy-a-prospective-study-comparing-data-from-phase-analysis-of-gated-myocardial-perfusion-single-photon-computed-tomography-and-echocardiography-trying-to-anticipate-response-to-crt
#7
Rémy Gendre, O Lairez, P Mondoly, A Duparc, D Carrié, M Galinier, I Berry, T Cognet
BACKGROUND: Cardiac resynchronization therapy (CRT) reduces morbidity and mortality in chronic systolic heart failure. About 20% of implanted patients are considered as "non-responders". This study aimed to evaluate gated myocardial perfusion single-photon emission computed tomography (GMPS) phase parameters as compared to echocardiography in the assessment of predictors for response to CRT before and after CRT activation. METHODS: Forty-two patients were prospectively included during 15 months...
February 14, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28197282/fragmented-qrs-as-a-marker-of-electrical-dyssynchrony-to-predict-inter-ventricular-conduction-defect-by-subsequent-echocardiographic-assessment-in-symptomatic-patients-of-non-ischemic-dilated-cardiomyopathy
#8
Santosh Kumar Sinha, Kush Bhagat, Mohammad Asif, Karandeep Singh, Mohit Sachan, Vikas Mishra, Nasar Afdaali, Mukesh Jitendra Jha, Ashutosh Kumar, Shravan Singh, Rupesh Sinha, Dibbendhu Khanra, Ramesh Thakur, Chandra Mohan Varma, Vinay Krishna, Umeshwar Pandey
BACKGROUND: Left ventricular (LV) dyssynchrony frequently occurs in patients with heart failure (HF). QRS ≥ 120 ms is a surrogate marker of electrical dyssynchrony, which occurs in only 30% of HF patients. In contrary, in those with normal QRS (nQRS) duration, LV dyssynchrony has been reported in 20-50%. This study was carried out to investigate the role of fragmented QRS (fQRS) on the surface electrocardiography (ECG) as a marker of electrical dyssynchrony to predict the presence of significant intraventricular dyssynchrony (IVD) by subsequent echocardiographic assessment...
August 2016: Cardiology Research
https://www.readbyqxmd.com/read/28197275/cardiac-resynchronization-therapy-leads-to-improvements-in-handgrip-strength
#9
David R Warriner, Patricia Lawford, Paul J Sheridan
BACKGROUND: A reduction in skeletal muscle performance measured by handgrip strength is common in heart failure. No trial has investigated the role of cardiac resynchronization therapy, which leads to improvements in cardiac performance, on the function of skeletal muscle in patients with heart failure. METHODS: Nineteen patients were recruited, 18 male, age 69 ± 8 years, New York Heart Association class II-IV, QRS duration 173 ± 21 ms and left ventricular ejection fraction 26±8%...
June 2016: Cardiology Research
https://www.readbyqxmd.com/read/28194611/using-three-dimensional-echocardiography-to-guide-left-ventricle-lead-position-in-cardiac-resynchronization-therapy-does-it-make-any-difference
#10
Haitham A Badran, John Z Kamel, Tarek R Mohamed, Mohamed A Abdelhamid
BACKGROUND: Cardiac resynchronization therapy (CRT) is an effective treatment for patients with advanced heart failure. Nearly 30% of candidates are inadequate responders. Proper patient selection, left ventricle (LV) lead placement optimization, and optimization of the programming of the CRT device are important approaches to improve outcome of CRT. We examined the role of three-dimensional (3D) echocardiography in determining the optimal LV lead position as a method of optimizing CRT response...
February 13, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28188000/effectiveness-of-a-management-program-for-outpatient-clinic-or-remote-titration-of-beta-blockers-in-crt-patients-the-restore-study
#11
Antonio D'Onofrio, Pietro Palmisano, Antonio Rapacciuolo, Ernesto Ammendola, Leonardo Calò, Antonio Ruocco, Valter Bianchi, Fabio Maresca, Giuseppe Del Giorno, Annamaria Martino, Ciro Mauro, Monica Campari, Sergio Valsecchi, Michele Accogli
BACKGROUND: Many patients fail to receive β-blockers before cardiac resynchronization therapy defibrillator (CRT-D) implantation, or receive them at a suboptimal dose, and require optimization after implantation. We assessed the effectiveness of a structured program for β-blocker titration in CRT-D patients followed up by means of conventional in-clinic visits or remote monitoring. METHODS AND RESULTS: 130 patients undergoing CRT implantation and treated according to the standard practice of the centers were included as a control group...
February 5, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28181011/intracardiac-impedance-after-cardiac-resynchronization-therapy-is-a-novel-predictor-for-worsening-of-heart-failure
#12
Hitoshi Suzuki, Minoru Nodera, Masashi Kamioka, Takashi Kaneshiro, Yoshiyuki Kamiyama, Yasuchika Takeishi
Intrathoracic impedance measured by cardiac resynchronization therapy (CRT) varies because several factors other than pulmonary congestion may affect this parameter. Therefore, we hypothesized that changes in intracardiac impedance between the right and left ventricular leads would be more accurate to identify worsening heart failure in patients with CRT. The study enrolled 21 patients with CRT defibrillator (15 males, 70 ± 12 years). During the follow-up period (12 ± 7 months), the subjects experienced 37 fluid index threshold (60 ohm-days) crossing events...
February 8, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28177451/erratum-to-increasing-sex-differences-in-the-use-of-cardiac-resynchronization-therapy-with-or-without-implantable-cardioverterdefibrillator-eur-heart-j-2017-doi-10-1093-eurheartj-ehw598
#13
(no author information available yet)
No abstract text is available yet for this article.
February 8, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28176442/impact-of-remote-monitoring-on-long-term-prognosis-in-heart-failure-patients-in-a-real-world-cohort-results-from-all-comers-commit-hf-trial
#14
Anna Kurek, Mateusz Tajstra, Elzbieta Gadula-Gacek, Piotr Buchta, Michal Skrzypek, Lukasz Pyka, Michal Wasiak, Malgorzata Swietlinska, Michal Hawranek, Lech Polonski, Mariusz Gasior, Jedrzej Kosiuk
BACKGROUND: Randomized controlled trials demonstrate that remote monitoring (RM) of implantable cardioverter-defibrillators (ICDs) and cardiac resynchronization therapy devices (CRT-D) may improve quality of care and prognosis in heart failure (HF) patients. However, the impact of RM on long-term mortality in a real-world cohort is still not well examined. METHODS AND RESULTS: This study was designed as a matched cohort study based on the COMMIT-HF trial - a single-center, ongoing prospective observational registry (NCT02536443)...
February 8, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28176418/impact-of-qrs-complex-duration-and-morphology-on-left-ventricular-reverse-remodelling-and-left-ventricular-function-improvement-after-cardiac-resynchronization-therapy
#15
Pieter van der Bijl, Mand Khidir, Melissa Leung, Bart Mertens, Nina Ajmone Marsan, Victoria Delgado, Jeroen J Bax
AIMS: To evaluate the impact of the interaction of QRS duration and morphology on left ventricular (LV) reverse remodelling and LV functional improvement in heart failure (HF) patients treated with cardiac resynchronization therapy (CRT). METHODS AND RESULTS: From an ongoing registry of HF patients treated with CRT according to contemporary guidelines, demographic, clinical, electrocardiographic (ECG) and echocardiographic characteristics were analysed. Patients were divided according to QRS duration and morphology: <150 ms vs...
February 8, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28176416/association-between-demographic-organizational-clinical-and-socio-economic-characteristics-and-underutilization-of-cardiac-resynchronization-therapy-results-from-the-swedish-heart-failure-registry
#16
Lars H Lund, Frieder Braunschweig, Lina Benson, Marcus Ståhlberg, Ulf Dahlström, Cecilia Linde
AIMS: Cardiac resynchronization therapy (CRT) improves outcomes in heart failure (HF) but may be underutilized. The reasons are unknown. METHODS AND RESULTS: We linked the Swedish Heart Failure Registry to national registries with ICD-10 (International Classification of Diseases-10th Revision) co-morbidity diagnoses and demographic and socio-economic data. In patients with EF ≤39% and NYHA II-IV, we assessed prevalence of CRT indication and CRT use. In those with CRT indication, we assessed the association between 37 potential baseline covariates and CRT non-use using multivariable generalized estimating equation (GEE) models...
February 7, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28176410/echocardiographic-predictors-of-long-term-survival-in-patients-undergoing-cardiac-resynchronization-therapy-what-is-the-optimal-metric
#17
John Rickard, Bryan Baranowski, W H Wilson Tang, Richard A Grimm, Mark Niebauer, Daniel Cantillion, Bruce L Wilkoff, Niraj Varma
BACKGROUND: Multiple definitions of reverse ventricular remodeling(RVR) employing various changes in left ventricular end-systolic (LVESV) or diastolic volumes (LVEDV) or left ventricular ejection fraction(LVEF) have been used in determining cardiac resynchronization (CRT) response, making comparability across studies difficult. We compared different metrics to each other, and in combination, in terms of association with long-term outcomes. METHODS: We collected clinical and echocardiographic data on 436 patients undergoing CRT...
February 8, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28169058/accuracy-of-computer-calculated-and-manual-qrs-duration-assessments-clinical-implications-to-select-candidates-for-cardiac-resynchronization-therapy
#18
Jan De Pooter, Milad El Haddad, Roland Stroobandt, Marc De Buyzere, Frank Timmermans
BACKGROUND: QRS duration (QRSD) plays a key role in the field of cardiac resynchronization therapy (CRT). Computer-calculated QRSD assessments are widely used, however inter-manufacturer differences have not been investigated in CRT candidates. METHODS: QRSD was assessed in 377 digitally stored ECGs: 139 narrow QRS, 140 LBBB and 98 ventricular paced ECGs. Manual QRSD was measured as global QRSD, using digital calipers, by two independent observers. Computer-calculated QRSD was assessed by Marquette 12SL (GE Healthcare, Waukesha, WI, USA) and SEMA3 (Schiller, Baar, Switzerland)...
January 31, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28164328/left-ventricular-size-does-not-modify-the-effect-of-qrs-duration-in-predicting-response-to-cardiac-resynchronization-therapy
#19
John Rickard, Bryan Baranowski, Richard A Grimm, Mark Niebauer, Niraj Varma, Wh Wilson Tang, Bruce L Wilkoff
BACKGROUND: QRS duration(QRSd) may be impacted by both left ventricular (LV) dilatation and conduction delay. It is possible therefore that the same QRSd may portend significantly different amounts of LV activation delay in patients with small versus large left ventricles. We hypothesized that LV size modifies the effect of QRSd on predicting outcomes in patients undergoing CRT implant. METHODS: We extracted data on consecutive patients presenting for initial CRT implant...
February 6, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28163146/the-subcutaneous-icd-as-an-alternative-to-the-conventional-icd-system-initial-experience-in-greece-and-review-of-the-literature
#20
REVIEW
Skevos Sideris, Stefanos Archontakis, Konstantinos A Gatzoulis, Aristotelis Anastasakis, Ilias Sotiropoulos, Petros Arsenos, Alexandros Kasiakogias, Dimitrios Terentes, Konstantinos Trachanas, Eleftherios Paschalidis, Dimitrios Tousoulis, Ioannis Kallikazaros
The introduction of the implantable cardioverter defibrillator (ICD) in clinical practice has revolutionized our therapeutic approach for sudden cardiac death (SCD) both in the context of primary and secondary prevention, since it has proven to be superior to medical therapy in treating potentially life-threatening ventricular arrhythmias, resulting in reduced mortality rates. However, conventional ICDs' implantation carries a not negligible risk of periprocedural and long-term complications associated with the transvenous ICD leads...
February 2, 2017: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
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